TreeWAS – Variant ID: rs2244608

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	Risk posterior probability	No effect posterior probability	Protective posterior probability
E78.0 Pure hypercholesterolaemia	1.000	0.000	0.000
I25.1 Atherosclerotic heart disease	1.000	0.000	0.000
K80.2 Calculus of gallbladder without cholecystitis	0.000	0.000	1.000
I25 Chronic ischaemic heart disease	1.000	0.000	0.000
K80 Cholelithiasis	0.000	0.000	1.000
K80.1 Calculus of gallbladder with other cholecystitis	0.000	0.000	1.000
I20-I25 Ischaemic heart diseases	1.000	0.000	0.000
I20 Angina pectoris	1.000	0.000	0.000
E11.9 Without complications	1.000	0.000	0.000
I20.0 Unstable angina	0.999	0.001	0.000
E78 Disorders of lipoprotein metabolism and other lipidaemias	0.999	0.001	0.000
E11 Non-insulin-dependent diabetes mellitus	0.999	0.001	0.000
E10-E14 Diabetes mellitus	0.998	0.002	0.000
I25.9 Chronic ischaemic heart disease, unspecified	0.997	0.003	0.000
E10 Insulin-dependent diabetes mellitus	0.996	0.004	0.000
E70-E90 Metabolic disorders	0.986	0.014	0.000
Chapter IV Endocrine, nutritional and metabolic diseases	0.977	0.023	0.000
K80-K87 Disorders of gallbladder, biliary tract and pancreas	0.000	0.029	0.971
E87 Other disorders of fluid, electrolyte and acid-base balance	0.970	0.030	0.000
K81 Cholecystitis	0.000	0.036	0.964
K81.1 Chronic cholecystitis	0.000	0.042	0.958
I25.2 Old myocardial infarction	0.953	0.047	0.000
E87.6 Hypokalaemia	0.951	0.049	0.000
I22 Subsequent myocardial infarction	0.951	0.049	0.000
E10.3 With ophthalmic complications	0.951	0.049	0.000
E78.9 Disorder of lipoprotein metabolism, unspecified	0.949	0.051	0.000
E10.2 With renal complications	0.931	0.069	0.000
I22.9 Subsequent myocardial infarction of unspecified site	0.908	0.092	0.000
E10.4 With neurological complications	0.897	0.103	0.000
E10.8 With unspecified complications	0.897	0.103	0.000
E10.5 With peripheral circulatory complications	0.891	0.109	0.000
E78.4 Other hyperlipidaemia	0.891	0.109	0.000
I20.8 Other forms of angina pectoris	0.887	0.113	0.000
K80.8 Other cholelithiasis	0.000	0.114	0.886
E87.5 Hyperkalaemia	0.874	0.126	0.000
I25.0 Atherosclerotic cardiovascular disease, so described	0.869	0.131	0.000
E11.4 With neurological complications	0.860	0.140	0.000
I21 Acute myocardial infarction	0.849	0.151	0.000
E78.5 Hyperlipidaemia, unspecified	0.848	0.152	0.000
E87.2 Acidosis	0.846	0.154	0.000
I25.5 Ischaemic cardiomyopathy	0.843	0.157	0.000
E88 Other metabolic disorders	0.838	0.162	0.000
I22.8 Subsequent myocardial infarction of other sites	0.816	0.184	0.000
I20.9 Angina pectoris, unspecified	0.814	0.186	0.000
K85 Acute pancreatitis	0.000	0.187	0.813
I25.4 Coronary artery aneurysm	0.795	0.205	0.000
E78.1 Pure hyperglyceridaemia	0.794	0.206	0.000
I21.1 Acute transmural myocardial infarction of inferior wall	0.789	0.211	0.000
K86 Other diseases of pancreas	0.000	0.219	0.781
E74 Other disorders of carbohydrate metabolism	0.771	0.229	0.000
K82 Other diseases of gallbladder	0.000	0.232	0.768
E87.3 Alkalosis	0.765	0.235	0.000
K81.0 Acute cholecystitis	0.000	0.238	0.762
K85.1 Biliary acute pancreatitis	0.000	0.239	0.761
K80.4 Calculus of bile duct with cholecystitis	0.000	0.240	0.760
E10.7 With multiple complications	0.759	0.241	0.000
E11.0 With coma	0.758	0.242	0.000
E11.3 With ophthalmic complications	0.757	0.243	0.000
E72 Other disorders of amino-acid metabolism	0.756	0.244	0.000
K81.9 Cholecystitis, unspecified	0.000	0.249	0.751
E10.0 With coma	0.749	0.251	0.000
E75 Disorders of sphingolipid metabolism and other lipid storage disorders	0.748	0.252	0.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion	0.739	0.261	0.000
E11.6 With other specified complications	0.735	0.265	0.000
E84 Cystic fibrosis	0.734	0.266	0.000
E11.1 With ketoacidosis	0.730	0.270	0.000
E88.0 Disorders of plasma-protein metabolism, not elsewhere classified	0.723	0.277	0.000
K86.2 Cyst of pancreas	0.000	0.279	0.721
E70 Disorders of aromatic amino-acid metabolism	0.720	0.279	0.000
I25.6 Silent myocardial ischaemia	0.717	0.283	0.000
K80.3 Calculus of bile duct with cholangitis	0.000	0.283	0.717
E11.7 With multiple complications	0.716	0.284	0.000
E12 Malnutrition-related diabetes mellitus	0.716	0.284	0.000
E78.3 Hyperchylomicronaemia	0.715	0.285	0.000
E13 Other specified diabetes mellitus	0.714	0.286	0.000
E77 Disorders of glycoprotein metabolism	0.707	0.293	0.000
E76 Disorders of glycosaminoglycan metabolism	0.707	0.293	0.000
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism	0.707	0.293	0.000
E90 Nutritional and metabolic disorders in diseases classified elsewhere	0.707	0.293	0.000
E11.8 With unspecified complications	0.704	0.296	0.000
E87.7 Fluid overload	0.703	0.297	0.000
E87.0 Hyperosmolality and hypernatraemia	0.698	0.302	0.000
I22.0 Subsequent myocardial infarction of anterior wall	0.697	0.303	0.000
K87 Disorders of gallbladder, biliary tract and pancreas in diseases classified elsewhere	0.000	0.304	0.696
E87.4 Mixed disorder of acid-base balance	0.696	0.304	0.000
E10.6 With other specified complications	0.696	0.304	0.000
K86.1 Other chronic pancreatitis	0.000	0.312	0.688
K82.4 Cholesterolosis of gallbladder	0.000	0.314	0.686
E73 Lactose intolerance	0.677	0.323	0.000
E78.6 Lipoprotein deficiency	0.676	0.324	0.000
E88.3 Tumour lysis syndrome	0.674	0.326	0.000
E79 Disorders of purine and pyrimidine metabolism	0.674	0.326	0.000
E78.8 Other disorders of lipoprotein metabolism	0.669	0.331	0.000
K82.1 Hydrops of gallbladder	0.000	0.334	0.666
I21.9 Acute myocardial infarction, unspecified	0.663	0.337	0.000
E85 Amyloidosis	0.660	0.340	0.000
E11.2 With renal complications	0.659	0.341	0.000
E88.8 Other specified metabolic disorders	0.653	0.347	0.000
I23 Certain current complications following acute myocardial infarction	0.647	0.352	0.000
K81.8 Other cholecystitis	0.000	0.355	0.645
K85.2 Alcohol-induced acute pancreatitis	0.000	0.364	0.635
E78.2 Mixed hyperlipidaemia	0.619	0.380	0.000
E88.9 Metabolic disorder, unspecified	0.617	0.383	0.000
E74.3 Other disorders of intestinal carbohydrate absorption	0.616	0.383	0.000
I21.X Presumed acute myicardial infaction (unconfirmed)	0.608	0.391	0.000
I21.4 Acute subendocardial myocardial infarction	0.595	0.405	0.000
K85.0 Idiopathic acute pancreatitis	0.000	0.409	0.591
E72.1 Disorders of sulphur-bearing amino-acid metabolism	0.590	0.410	0.000
K82.0 Obstruction of gallbladder	0.000	0.415	0.584
K85.3 Drug-induced acute pancreatitis	0.000	0.417	0.583
I21.3 Acute transmural myocardial infarction of unspecified site	0.582	0.418	0.000
K82.3 Fistula of gallbladder	0.000	0.421	0.579
E75.5 Other lipid storage disorders	0.576	0.423	0.000
E16 Other disorders of pancreatic internal secretion	0.568	0.432	0.000
K86.0 Alcohol-induced chronic pancreatitis	0.000	0.435	0.565
E10.1 With ketoacidosis	0.556	0.444	0.000
E84.9 Cystic fibrosis, unspecified	0.553	0.447	0.000
E74.9 Disorder of carbohydrate metabolism, unspecified	0.553	0.447	0.000
E74.8 Other specified disorders of carbohydrate metabolism	0.553	0.447	0.000
E74.4 Disorders of pyruvate metabolism and gluconeogenesis	0.553	0.447	0.000
E74.2 Disorders of galactose metabolism	0.553	0.447	0.000
E74.1 Disorders of fructose metabolism	0.553	0.447	0.000
E74.0 Glycogen storage disease	0.553	0.447	0.000
I25.3 Aneurysm of heart	0.545	0.455	0.000
E72.9 Disorder of amino-acid metabolism, unspecified	0.542	0.458	0.000
E72.8 Other specified disorders of amino-acid metabolism	0.542	0.458	0.000
E72.5 Disorders of glycine metabolism	0.542	0.458	0.000
E72.4 Disorders of ornithine metabolism	0.542	0.458	0.000
E72.3 Disorders of lysine and hydroxylysine metabolism	0.542	0.458	0.000
E72.2 Disorders of urea cycle metabolism	0.542	0.458	0.000
E72.0 Disorders of amino-acid transport	0.542	0.458	0.000
E50-E64 Other nutritional deficiencies	0.540	0.460	0.000
I20.1 Angina pectoris with documented spasm	0.537	0.463	0.000
E75.6 Lipid storage disorder, unspecified	0.536	0.464	0.000
E75.4 Neuronal ceroid lipofuscinosis	0.536	0.464	0.000
E75.3 Sphingolipidosis, unspecified	0.536	0.464	0.000
E75.2 Other sphingolipidosis	0.536	0.464	0.000
E75.1 Other gangliosidosis	0.536	0.464	0.000
E75.0 GM2 gangliosidosis	0.536	0.464	0.000
K80.5 Calculus of bile duct without cholangitis or cholecystitis	0.000	0.468	0.532
E87.8 Other disorders of electrolyte and fluid balance, not elsewhere classified	0.530	0.470	0.000
E70.3 Albinism	0.530	0.470	0.000
E15 Nondiabetic hypoglycaemic coma	0.530	0.470	0.000
E85.9 Amyloidosis, unspecified	0.528	0.472	0.000
E84.8 Cystic fibrosis with other manifestations	0.526	0.473	0.000
E84.1 Cystic fibrosis with intestinal manifestations	0.526	0.473	0.000
E84.0 Cystic fibrosis with pulmonary manifestations	0.526	0.473	0.000
I21.0 Acute transmural myocardial infarction of anterior wall	0.520	0.480	0.000
K80.0 Calculus of gallbladder with acute cholecystitis	0.000	0.482	0.518
E88.1 Lipodystrophy, not elsewhere classified	0.517	0.483	0.000
E70.9 Disorder of aromatic amino-acid metabolism, unspecified	0.517	0.483	0.000
E70.8 Other disorders of aromatic amino-acid metabolism	0.517	0.483	0.000
E70.2 Disorders of tyrosine metabolism	0.517	0.483	0.000
E70.1 Other hyperphenylalaninaemias	0.517	0.483	0.000
E70.0 Classical phenylketonuria	0.517	0.483	0.000
E88.2 Lipomatosis, not elsewhere classified	0.516	0.484	0.000
K80.36 Calculus of bile duct with acute and chronic cholangitis without obstruction	0.000	0.486	0.514
E12.9 Without complications	0.513	0.487	0.000
E12.8 With unspecified complications	0.513	0.487	0.000
E12.7 With multiple complications	0.513	0.487	0.000
E12.6 With other specified complications	0.513	0.487	0.000
E12.5 With peripheral circulatory complications	0.513	0.487	0.000
E12.4 With neurological complications	0.513	0.487	0.000
E12.3 With ophthalmic complications	0.513	0.487	0.000
E12.2 With renal complications	0.513	0.487	0.000
E12.1 With ketoacidosis	0.513	0.487	0.000
E12.0 With coma	0.513	0.487	0.000
E13.8 With unspecified complications	0.512	0.488	0.000
E13.7 With multiple complications	0.512	0.488	0.000
E13.6 With other specified complications	0.512	0.488	0.000
E13.5 With peripheral circulatory complications	0.512	0.488	0.000
E13.4 With neurological complications	0.512	0.488	0.000
E13.3 With ophthalmic complications	0.512	0.488	0.000
E13.2 With renal complications	0.512	0.488	0.000
E13.1 With ketoacidosis	0.512	0.488	0.000
E13.0 With coma	0.512	0.488	0.000
E13.9 Without complications	0.510	0.490	0.000
E71.3 Disorders of fatty-acid metabolism	0.507	0.493	0.000
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified	0.507	0.493	0.000
E71.1 Other disorders of branched-chain amino-acid metabolism	0.507	0.493	0.000
E71.0 Maple-syrup-urine disease	0.507	0.493	0.000
E76.9 Disorder of glucosaminoglycan metabolism, unspecified	0.507	0.493	0.000
E76.8 Other disorders of glucosaminoglycan metabolism	0.507	0.493	0.000
E76.3 Mucopolysaccharidosis, unspecified	0.507	0.493	0.000
E76.2 Other mucopolysaccharidoses	0.507	0.493	0.000
E76.1 Mucopolysaccharidosis, type II	0.507	0.493	0.000
E76.0 Mucopolysaccharidosis, type I	0.507	0.493	0.000
E77.9 Disorder of glycoprotein metabolism, unspecified	0.507	0.493	0.000
E77.8 Other disorders of glycoprotein metabolism	0.507	0.493	0.000
E77.1 Defects in glycoprotein degradation	0.507	0.493	0.000
E77.0 Defects in posttranslational modification of lysosomal enzymes	0.507	0.493	0.000
I21.2 Acute transmural myocardial infarction of other sites	0.501	0.499	0.000
K87.1 Disorders of pancreas in diseases classified elsewhere	0.000	0.501	0.499
K87.0 Disorders of gallbladder and biliary tract in diseases classified elsewhere	0.000	0.501	0.499
E40-E46 Malnutrition	0.496	0.503	0.000
E73.8 Other lactose intolerance	0.486	0.514	0.000
E73.1 Secondary lactase deficiency	0.486	0.514	0.000
E73.0 Congenital lactase deficiency	0.486	0.514	0.000
K82.8 Other specified diseases of gallbladder	0.000	0.516	0.484
E79.9 Disorder of purine and pyrimidine metabolism, unspecified	0.483	0.517	0.000
E79.8 Other disorders of purine and pyrimidine metabolism	0.483	0.517	0.000
E79.1 Lesch-Nyhan syndrome	0.483	0.517	0.000
I22.1 Subsequent myocardial infarction of inferior wall	0.478	0.522	0.000
K85.8 Other acute pancreatitis	0.000	0.523	0.477
E85.8 Other amyloidosis	0.473	0.527	0.000
E85.2 Heredofamilial amyloidosis, unspecified	0.473	0.527	0.000
E85.1 Neuropathic heredofamilial amyloidosis	0.473	0.527	0.000
E85.0 Nonneuropathic heredofamilial amyloidosis	0.473	0.527	0.000
E65-E68 Obesity and other hyperalimentation	0.472	0.527	0.000
E16.1 Other hypoglycaemia	0.469	0.531	0.000
E16.0 Drug-induced hypoglycaemia without coma	0.468	0.532	0.000
E85.3 Secondary systemic amyloidosis	0.466	0.534	0.000
K86.8 Other specified diseases of pancreas	0.000	0.534	0.466
I23.6 Thrombosis of atrium, auricular appendage and ventricle as current complications following acute myocardial infarction	0.464	0.535	0.000
I23.5 Rupture of papillary muscle as current complication following acute myocardial infarction	0.464	0.535	0.000
I23.4 Rupture of chordae tendineae as current complication following acute myocardial infarction	0.464	0.535	0.000
I23.3 Rupture of cardiac wall without haemopericardium as current complication following acute myocardial infarction	0.464	0.535	0.000
I23.2 Ventricular septal defect as current complication following acute myocardial infarction	0.464	0.535	0.000
I23.1 Atrial septal defect as current complication following acute myocardial infarction	0.464	0.535	0.000
I23.0 Haemopericardium as current complication following acute myocardial infarction	0.464	0.535	0.000
E11.5 With peripheral circulatory complications	0.457	0.543	0.000
E73.9 Lactose intolerance, unspecified	0.455	0.544	0.000
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease	0.449	0.551	0.000
I25.8 Other forms of chronic ischaemic heart disease	0.448	0.552	0.000
K82.2 Perforation of gallbladder	0.000	0.555	0.445
E51 Thiamine deficiency	0.425	0.575	0.000
I24 Other acute ischaemic heart diseases	0.410	0.589	0.000
K86.3 Pseudocyst of pancreas	0.000	0.592	0.408
E16.9 Disorder of pancreatic internal secretion, unspecified	0.407	0.593	0.000
E16.8 Other specified disorders of pancreatic internal secretion	0.407	0.593	0.000
E16.4 Abnormal secretion of gastrin	0.407	0.593	0.000
E16.3 Increased secretion of glucagon	0.407	0.593	0.000
I95.1 Orthostatic hypotension	0.397	0.603	0.000
I23.8 Other current complications following acute myocardial infarction	0.395	0.605	0.000
E56 Other vitamin deficiencies	0.390	0.609	0.000
E64 Sequelae of malnutrition and other nutritional deficiencies	0.388	0.612	0.000
E63 Other nutritional deficiencies	0.388	0.612	0.000
E50 Vitamin A deficiency	0.388	0.612	0.000
E60 Dietary zinc deficiency	0.388	0.612	0.000
E59 Dietary selenium deficiency	0.388	0.612	0.000
E54 Ascorbic acid deficiency	0.388	0.612	0.000
E52 Niacin deficiency [pellagra]	0.388	0.612	0.000
E58 Dietary calcium deficiency	0.371	0.629	0.000
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified	0.367	0.633	0.000
E14 Unspecified diabetes mellitus	0.366	0.634	0.000
K85.9 Acute pancreatitis, unspecified	0.000	0.639	0.361
E44 Protein-energy malnutrition of moderate and mild degree	0.356	0.644	0.000
E45 Retarded development following protein-energy malnutrition	0.356	0.644	0.000
E43 Unspecified severe protein-energy malnutrition	0.356	0.644	0.000
E42 Marasmic kwashiorkor	0.356	0.644	0.000
E41 Nutritional marasmus	0.356	0.644	0.000
E40 Kwashiorkor	0.356	0.644	0.000
E65 Localised adiposity	0.354	0.646	0.000
E55 Vitamin D deficiency	0.352	0.648	0.000
I24.1 Dressler's syndrome	0.348	0.652	0.000
E51.2 Wernicke's encephalopathy	0.343	0.657	0.000
E85.4 Organ-limited amyloidosis	0.339	0.660	0.000
E67 Other hyperalimentation	0.339	0.661	0.000
E68 Sequelae of hyperalimentation	0.339	0.661	0.000
E80 Disorders of porphyrin and bilirubin metabolism	0.330	0.669	0.001
I95 Hypotension	0.330	0.670	0.000
E20-E35 Disorders of other endocrine glands	0.328	0.672	0.000
E53 Deficiency of other B group vitamins	0.326	0.674	0.000
E61 Deficiency of other nutrient elements	0.319	0.681	0.000
I95-I99 Other and unspecified disorders of the circulatory system	0.306	0.694	0.000
E51.9 Thiamine deficiency, unspecified	0.305	0.695	0.000
E51.8 Other manifestations of thiamine deficiency	0.305	0.695	0.000
E51.1 Beriberi	0.305	0.695	0.000
I95.2 Hypotension due to drugs	0.304	0.696	0.000
E14.2 Withrenal complications	0.304	0.696	0.000
E14.4 With neurological complications	0.300	0.700	0.000
E14.5 With peripheral circulatory complications	0.300	0.700	0.000
I97 Postprocedural disorders of circulatory system, not elsewhere classified	0.291	0.709	0.000
E56.1 Deficiency of vitamin K	0.283	0.717	0.000
I97.1 Other functional disturbances following cardiac surgery	0.281	0.718	0.000
E56.9 Vitamin deficiency, unspecified	0.280	0.720	0.000
E56.8 Deficiency of other vitamins	0.280	0.720	0.000
E56.0 Deficiency of vitamin E	0.280	0.720	0.000
E50.9 Vitamin A deficiency, unspecified	0.278	0.722	0.000
E50.8 Other manifestations of vitamin A deficiency	0.278	0.722	0.000
E50.7 Other ocular manifestations of vitamin A deficiency	0.278	0.722	0.000
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea	0.278	0.722	0.000
E50.5 Vitamin A deficiency with night blindness	0.278	0.722	0.000
E50.4 Vitamin A deficiency with keratomalacia	0.278	0.722	0.000
E50.3 Vitamin A deficiency with corneal ulceration and xerosis	0.278	0.722	0.000
E50.2 Vitamin A deficiency with corneal xerosis	0.278	0.722	0.000
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis	0.278	0.722	0.000
E50.0 Vitamin A deficiency with conjunctival xerosis	0.278	0.722	0.000
E63.9 Nutritional deficiency, unspecified	0.278	0.722	0.000
E63.8 Other specified nutritional deficiencies	0.278	0.722	0.000
E63.1 Imbalance of constituents of food intake	0.278	0.722	0.000
E63.0 Essential fatty acid [EFA] deficiency	0.278	0.722	0.000
E64.9 Sequelae of unspecified nutritional deficiency	0.278	0.722	0.000
E64.8 Sequelae of other nutritional deficiencies	0.278	0.722	0.000
E64.3 Sequelae of rickets	0.278	0.722	0.000
E64.2 Sequelae of vitamin C deficiency	0.278	0.722	0.000
E64.1 Sequelae of vitamin A deficiency	0.278	0.722	0.000
E64.0 Sequelae of protein-energy malnutrition	0.278	0.722	0.000
E27 Other disorders of adrenal gland	0.277	0.723	0.000
E53.9 Vitamin B deficiency, unspecified	0.276	0.724	0.000
K86.9 Disease of pancreas, unspecified	0.000	0.728	0.272
E89.3 Postprocedural hypopituitarism	0.270	0.730	0.000
Chapter IX Diseases of the circulatory system	0.269	0.731	0.000
E83 Disorders of mineral metabolism	0.269	0.731	0.000
E89.1 Postprocedural hypoinsulinaemia	0.266	0.734	0.000
E26 Hyperaldosteronism	0.266	0.734	0.000
E89.9 Postprocedural endocrine and metabolic disorder, unspecified	0.263	0.737	0.000
E89.8 Other postprocedural endocrine and metabolic disorders	0.263	0.737	0.000
E89.5 Postprocedural testicular hypofunction	0.263	0.737	0.000
E14.7 With multiple complications	0.262	0.738	0.000
E14.0 With coma	0.262	0.738	0.000
E89.6 Postprocedural adrenocortical(-medullary) hypofunction	0.262	0.738	0.000
E27.9 Disorder of adrenal gland, unspecified	0.259	0.741	0.000
E44.1 Mild protein-energy malnutrition	0.255	0.744	0.000
E44.0 Moderate protein-energy malnutrition	0.255	0.744	0.000
E55.0 Rickets, active	0.253	0.747	0.000
E31 Polyglandular dysfunction	0.252	0.748	0.000
E89.4 Postprocedural ovarian failure	0.251	0.749	0.000
E27.2 Addisonian crisis	0.250	0.750	0.000
E25 Adrenogenital disorders	0.249	0.751	0.000
E29 Testicular dysfunction	0.249	0.751	0.000
E16.2 Hypoglycaemia, unspecified	0.244	0.756	0.000
E67.8 Other specified hyperalimentation	0.243	0.757	0.000
E67.3 Hypervitaminosis D	0.243	0.757	0.000
E67.2 Megavitamin-B6 syndrome	0.243	0.757	0.000
E67.1 Hypercarotenaemia	0.243	0.757	0.000
E67.0 Hypervitaminosis A	0.243	0.757	0.000
E83.4 Disorders of magnesium metabolism	0.238	0.762	0.000
E80.7 Disorder of bilirubin metabolism, unspecified	0.237	0.762	0.001
E80.5 Crigler-Najjar syndrome	0.237	0.762	0.001
E80.3 Defects of catalase and peroxydase	0.237	0.762	0.001
E80.0 Hereditary erythropoietic porphyria	0.237	0.762	0.001
E61.2 Magnesium deficiency	0.236	0.763	0.000
E35 Disorders of endocrine glands in diseases classified elsewhere	0.235	0.764	0.000
E32 Diseases of thymus	0.235	0.764	0.000
E30 Disorders of puberty, not elsewhere classified	0.235	0.764	0.000
E53.1 Pyridoxine deficiency	0.234	0.766	0.000
E53.0 Riboflavin deficiency	0.234	0.766	0.000
I97.8 Other postprocedural disorders of circulatory system, not elsewhere classified	0.234	0.766	0.000
E80.6 Other disorders of bilirubin metabolism	0.230	0.769	0.001
E14.1 With ketoacidosis	0.229	0.771	0.000
E20 Hypoparathyroidism	0.229	0.771	0.000
E61.9 Deficiency of nutrient element, unspecified	0.229	0.771	0.000
E61.8 Deficiency of other specified nutrient elements	0.229	0.771	0.000
E61.7 Deficiency of multiple nutrient elements	0.229	0.771	0.000
E61.6 Vanadium deficiency	0.229	0.771	0.000
E61.5 Molybdenum deficiency	0.229	0.771	0.000
E61.4 Chromium deficiency	0.229	0.771	0.000
E61.3 Manganese deficiency	0.229	0.771	0.000
E61.0 Copper deficiency	0.229	0.771	0.000
E22 Hyperfunction of pituitary gland	0.229	0.771	0.000
I24.0 Coronary thrombosis not resulting in myocardial infarction	0.226	0.774	0.000
E14.6 With other specified complications	0.222	0.778	0.000
E55.9 Vitamin D deficiency, unspecified	0.217	0.782	0.000
E26.0 Primary hyperaldosteronism	0.217	0.783	0.000
E80.1 Porphyria cutanea tarda	0.214	0.786	0.001
E14.8 With unspecified complications	0.210	0.790	0.000
I97.9 Postprocedural disorder of circulatory system, unspecified	0.209	0.791	0.000
I97.0 Postcardiotomy syndrome	0.209	0.791	0.000
E80.2 Other porphyria	0.207	0.792	0.001
K82.9 Disease of gallbladder, unspecified	0.001	0.797	0.201
E21 Hyperparathyroidism and other disorders of parathyroid gland	0.202	0.798	0.000
I98 Other disorders of circulatory system in diseases classified elsewhere	0.200	0.799	0.000
E27.5 Adrenomedullary hyperfunction	0.199	0.801	0.000
E27.0 Other adrenocortical overactivity	0.199	0.801	0.000
E26.9 Hyperaldosteronism, unspecified	0.198	0.802	0.000
I24.9 Acute ischaemic heart disease, unspecified	0.197	0.803	0.000
E31.0 Autoimmune polyglandular failure	0.197	0.803	0.000
E83.9 Disorder of mineral metabolism, unspecified	0.193	0.807	0.000
E83.8 Other disorders of mineral metabolism	0.193	0.807	0.000
E83.2 Disorders of zinc metabolism	0.193	0.807	0.000
E83.0 Disorders of copper metabolism	0.193	0.807	0.000
E27.3 Drug-induced adrenocortical insufficiency	0.192	0.808	0.000
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency	0.192	0.808	0.000
E29.1 Testicular hypofunction	0.191	0.809	0.000
E26.8 Other hyperaldosteronism	0.191	0.809	0.000
E26.1 Secondary hyperaldosteronism	0.191	0.809	0.000
E34 Other endocrine disorders	0.191	0.809	0.000
I00-I02 Acute rheumatic fever	0.190	0.810	0.000
I05-I09 Chronic rheumatic heart diseases	0.189	0.811	0.000
E22.9 Hyperfunction of pituitary gland, unspecified	0.185	0.815	0.000
I50.1 Left ventricular failure	0.184	0.816	0.000
Z95 Presence of cardiac and vascular implants and grafts	0.181	0.819	0.000
E31.9 Polyglandular dysfunction, unspecified	0.180	0.819	0.000
E31.8 Other polyglandular dysfunction	0.180	0.819	0.000
E31.1 Polyglandular hyperfunction	0.180	0.819	0.000
Z95.5 Presence of coronary angioplasty implant and graft	0.181	0.819	0.000
Z95.9 Presence of cardiac and vascular implant and graft, unspecified	0.180	0.820	0.000
E25.9 Adrenogenital disorder, unspecified	0.179	0.821	0.000
E25.8 Other adrenogenital disorders	0.179	0.821	0.000
E27.8 Other specified disorders of adrenal gland	0.179	0.821	0.000
E29.9 Testicular dysfunction, unspecified	0.178	0.822	0.000
E29.8 Other testicular dysfunction	0.178	0.822	0.000
E29.0 Testicular hyperfunction	0.178	0.822	0.000
I97.2 Postmastectomy lymphoedema syndrome	0.176	0.824	0.000
I95.8 Other hypotension	0.175	0.824	0.000
I95.0 Idiopathic hypotension	0.173	0.826	0.000
Z95.1 Presence of aortocoronary bypass graft	0.173	0.827	0.000
E21.5 Disorder of parathyroid gland, unspecified	0.170	0.830	0.000
E30.9 Disorder of puberty, unspecified	0.169	0.831	0.000
E30.8 Other disorders of puberty	0.169	0.831	0.000
E30.1 Precocious puberty	0.169	0.831	0.000
E30.0 Delayed puberty	0.169	0.831	0.000
E32.9 Disease of thymus, unspecified	0.169	0.831	0.000
E32.8 Other diseases of thymus	0.169	0.831	0.000
E32.1 Abscess of thymus	0.169	0.831	0.000
E32.0 Persistent hyperplasia of thymus	0.169	0.831	0.000
E35.8 Disorders of other endocrine glands in diseases classified elsewhere	0.169	0.831	0.000
E35.1 Disorders of adrenal glands in diseases classified elsewhere	0.169	0.831	0.000
E35.0 Disorders of thyroid gland in diseases classified elsewhere	0.169	0.831	0.000
Z95.0 Presence of cardiac pacemaker	0.168	0.832	0.000
I06 Rheumatic aortic valve diseases	0.167	0.833	0.000
E14.3 With ophthalmic complications	0.166	0.834	0.000
E22.0 Acromegaly and pituitary gigantism	0.166	0.834	0.000
E20.8 Other hypoparathyroidism	0.164	0.836	0.000
E20.1 Pseudohypoparathyroidism	0.164	0.836	0.000
E20.0 Idiopathic hypoparathyroidism	0.164	0.836	0.000
E22.8 Other hyperfunction of pituitary gland	0.164	0.836	0.000
E22.1 Hyperprolactinaemia	0.164	0.836	0.000
E21.1 Secondary hyperparathyroidism, not elsewhere classified	0.162	0.838	0.000
E89.0 Postprocedural hypothyroidism	0.160	0.840	0.000
E20.9 Hypoparathyroidism, unspecified	0.157	0.842	0.000
E46 Unspecified protein-energy malnutrition	0.152	0.848	0.001
I50 Heart failure	0.148	0.852	0.000
E89.2 Postprocedural hypoparathyroidism	0.146	0.853	0.000
Z95.8 Presence of other cardiac and vascular implants and grafts	0.147	0.853	0.000
E61.1 Iron deficiency	0.144	0.855	0.000
I98.8 Other specified disorders of circulatory system in diseases classified elsewhere	0.144	0.856	0.000
I98.1 Cardiovascular disorders in other infectious and parasitic diseases classified elsewhere	0.144	0.856	0.000
I98.0 Cardiovascular syphilis	0.144	0.856	0.000
E24 Cushing's syndrome	0.142	0.857	0.001
E34.3 Short stature, not elsewhere classified	0.142	0.858	0.000
I06.1 Rheumatic aortic insufficiency	0.141	0.859	0.000
E21.4 Other specified disorders of parathyroid gland	0.141	0.859	0.000
I98.2 Oesophageal varices in diseases classified elsewhere	0.140	0.860	0.000
I24.8 Other forms of acute ischaemic heart disease	0.139	0.860	0.000
E21.2 Other hyperparathyroidism	0.139	0.861	0.000
E34.5 Androgen resistance syndrome	0.137	0.863	0.000
E34.4 Constitutional tall stature	0.137	0.863	0.000
E34.2 Ectopic hormone secretion, not elsewhere classified	0.137	0.863	0.000
E34.1 Other hypersecretion of intestinal hormones	0.137	0.863	0.000
I02 Rheumatic chorea	0.136	0.864	0.000
I01 Rheumatic fever with heart involvement	0.136	0.864	0.000
I06.2 Rheumatic aortic stenosis with insufficiency	0.133	0.867	0.000
E34.8 Other specified endocrine disorders	0.133	0.867	0.000
Z95.3 Presence of xenogenic heart valve	0.133	0.867	0.000
I00 Rheumatic fever without mention of heart involvement	0.132	0.868	0.000
E27.4 Other and unspecified adrenocortical insufficiency	0.132	0.868	0.000
K83 Other diseases of biliary tract	0.000	0.868	0.132
I98.3 Oesophageal varices with bleeding in diseases classified elsewhere	0.130	0.870	0.000
E28 Ovarian dysfunction	0.129	0.870	0.000
I06.0 Rheumatic aortic stenosis	0.127	0.873	0.000
I08 Multiple valve diseases	0.126	0.874	0.000
I50.9 Heart failure, unspecified	0.123	0.877	0.000
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone	0.123	0.877	0.000
I07 Rheumatic tricuspid valve diseases	0.122	0.877	0.000
I06.9 Rheumatic aortic valve disease, unspecified	0.120	0.880	0.000
I06.8 Other rheumatic aortic valve diseases	0.120	0.880	0.000
I08.2 Disorders of both aortic and tricuspid valves	0.120	0.880	0.000
E34.0 Carcinoid syndrome	0.119	0.880	0.000
E23 Hypofunction and other disorders of pituitary gland	0.120	0.880	0.000
I09 Other rheumatic heart diseases	0.119	0.881	0.000
I05 Rheumatic mitral valve diseases	0.115	0.885	0.000
E34.9 Endocrine disorder, unspecified	0.114	0.886	0.000
I95.9 Hypotension, unspecified	0.112	0.888	0.000
K83.8 Other specified diseases of biliary tract	0.000	0.888	0.112
E83.1 Disorders of iron metabolism	0.108	0.891	0.000
I30-I52 Other forms of heart disease	0.105	0.895	0.000
I50.0 Congestive heart failure	0.104	0.896	0.000
E27.1 Primary adrenocortical insufficiency	0.103	0.897	0.000
E24.8 Other Cushing's syndrome	0.102	0.897	0.001
E24.4 Alcohol-induced pseudo-Cushing's syndrome	0.102	0.897	0.001
E24.3 Ectopic ACTH syndrome	0.102	0.897	0.001
E24.1 Nelson's syndrome	0.102	0.897	0.001
E21.3 Hyperparathyroidism, unspecified	0.103	0.897	0.000
I99 Other and unspecified disorders of circulatory system	0.099	0.900	0.000
I08.1 Disorders of both mitral and tricuspid valves	0.099	0.901	0.000
E24.0 Pituitary-dependent Cushing's disease	0.098	0.902	0.001
I01.9 Acute rheumatic heart disease, unspecified	0.098	0.902	0.000
I01.8 Other acute rheumatic heart disease	0.098	0.902	0.000
I01.2 Acute rheumatic myocarditis	0.098	0.902	0.000
I01.1 Acute rheumatic endocarditis	0.098	0.902	0.000
I01.0 Acute rheumatic pericarditis	0.098	0.902	0.000
I02.9 Rheumatic chorea without heart involvement	0.098	0.902	0.000
I02.0 Rheumatic chorea with heart involvement	0.098	0.902	0.000
E24.2 Drug-induced Cushing's syndrome	0.096	0.903	0.001
K83.2 Perforation of bile duct	0.000	0.905	0.095
I70-I79 Diseases of arteries, arterioles and capillaries	0.095	0.905	0.000
E28.9 Ovarian dysfunction, unspecified	0.093	0.907	0.000
E28.8 Other ovarian dysfunction	0.093	0.907	0.000
E28.1 Androgen excess	0.093	0.907	0.000
E28.0 Oestrogen excess	0.093	0.907	0.000
I30 Acute pericarditis	0.090	0.910	0.000
E00-E07 Disorders of thyroid gland	0.089	0.910	0.000
E21.0 Primary hyperparathyroidism	0.089	0.911	0.000
K83.5 Biliary cyst	0.000	0.911	0.089
K83.4 Spasm of sphincter of Oddi	0.000	0.911	0.088
I72 Other aneurysm	0.088	0.912	0.000
I07.9 Tricuspid valve disease, unspecified	0.088	0.912	0.000
I07.8 Other tricuspid valve diseases	0.088	0.912	0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations