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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs2246330
log Bayes Factor = 71.8146
Chromosome 6   position 31,041,493  (GRCh37) Explore rs2246330 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E03.9 Hypothyroidism, unspecified
1.000 0.000 0.000
K90.0 Coeliac disease
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
R31 Unspecified haematuria
1.000 0.000 0.000
L40.9 Psoriasis, unspecified
0.000 0.000 1.000
E10-E14 Diabetes mellitus
0.000 0.000 1.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.002 0.998
E10.1 With ketoacidosis
0.000 0.002 0.998
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.003 0.997
E16.2 Hypoglycaemia, unspecified
0.000 0.003 0.997
E16 Other disorders of pancreatic internal secretion
0.000 0.003 0.997
E10.3 With ophthalmic complications
0.000 0.006 0.994
E10.9 Without complications
0.000 0.009 0.991
L40 Psoriasis
0.000 0.011 0.989
E00-E07 Disorders of thyroid gland
0.043 0.022 0.935
L40.5 Arthropathic psoriasis
0.000 0.026 0.974
D86.9 Sarcoidosis, unspecified
0.000 0.034 0.966
D86 Sarcoidosis
0.000 0.036 0.964
E11 Non-insulin-dependent diabetes mellitus
0.000 0.043 0.957
L40.0 Psoriasis vulgaris
0.000 0.049 0.951
D80-D89 Certain disorders involving the immune mechanism
0.000 0.054 0.946
E05 Thyrotoxicosis [hyperthyroidism]
0.007 0.060 0.933
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.063 0.937
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.000 0.065 0.935
D70-D77 Other diseases of blood and blood-forming organs
0.000 0.070 0.930
D70 Agranulocytosis
0.000 0.076 0.924
E10.2 With renal complications
0.000 0.093 0.907
E11.5 With peripheral circulatory complications
0.000 0.098 0.902
E10.8 With unspecified complications
0.000 0.108 0.892
D86.1 Sarcoidosis of lymph nodes
0.000 0.112 0.888
E11.3 With ophthalmic complications
0.000 0.121 0.879
D50-D53 Nutritional anaemias
0.000 0.128 0.872
E11.4 With neurological complications
0.000 0.132 0.868
E10.5 With peripheral circulatory complications
0.000 0.137 0.863
E10.4 With neurological complications
0.000 0.140 0.860
D51 Vitamin B12 deficiency anaemia
0.000 0.161 0.839
D72 Other disorders of white blood cells
0.000 0.162 0.838
E50-E64 Other nutritional deficiencies
0.000 0.162 0.838
E10.6 With other specified complications
0.000 0.179 0.821
D86.0 Sarcoidosis of lung
0.000 0.190 0.810
E55 Vitamin D deficiency
0.000 0.204 0.796
D51.0 Vitamin B12 deficiency anaemia due to intrinsic factor deficiency
0.000 0.218 0.782
E11.8 With unspecified complications
0.000 0.219 0.781
D72.8 Other specified disorders of white blood cells
0.000 0.221 0.779
D75 Other diseases of blood and blood-forming organs
0.000 0.223 0.777
D80 Immunodeficiency with predominantly antibody defects
0.000 0.232 0.768
D86.8 Sarcoidosis of other and combined sites
0.000 0.234 0.766
E55.9 Vitamin D deficiency, unspecified
0.000 0.234 0.766
E03 Other hypothyroidism
0.423 0.235 0.342
L40.4 Guttate psoriasis
0.000 0.237 0.763
E10.0 With coma
0.000 0.238 0.762
E11.1 With ketoacidosis
0.000 0.241 0.759
E14 Unspecified diabetes mellitus
0.000 0.248 0.752
D83 Common variable immunodeficiency
0.000 0.253 0.746
D53 Other nutritional anaemias
0.000 0.256 0.744
D55-D59 Haemolytic anaemias
0.000 0.258 0.742
D86.2 Sarcoidosis of lung with sarcoidosis of lymph nodes
0.000 0.262 0.738
D51.9 Vitamin B12 deficiency anaemia, unspecified
0.000 0.263 0.737
L40.1 Generalised pustular psoriasis
0.000 0.263 0.737
D86.3 Sarcoidosis of skin
0.000 0.272 0.728
E10.7 With multiple complications
0.000 0.283 0.717
E12 Malnutrition-related diabetes mellitus
0.000 0.283 0.717
E15 Nondiabetic hypoglycaemic coma
0.000 0.285 0.715
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.285 0.715
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.285 0.715
E16.4 Abnormal secretion of gastrin
0.000 0.285 0.715
E16.3 Increased secretion of glucagon
0.000 0.285 0.715
E11.6 With other specified complications
0.000 0.288 0.712
L40.3 Pustulosis palmaris et plantaris
0.000 0.291 0.709
L40.2 Acrodermatitis continua
0.000 0.291 0.709
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions
0.000 0.292 0.708
E40-E46 Malnutrition
0.000 0.299 0.701
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.031 0.299 0.670
E00 Congenital iodine-deficiency syndrome
0.031 0.299 0.670
D59 Acquired haemolytic anaemia
0.000 0.307 0.693
E13 Other specified diabetes mellitus
0.000 0.309 0.691
E11.7 With multiple complications
0.000 0.314 0.686
D75.9 Disease of blood and blood-forming organs, unspecified
0.000 0.317 0.683
E06 Thyroiditis
0.022 0.317 0.661
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.319 0.681
E16.1 Other hypoglycaemia
0.000 0.321 0.679
D81 Combined immunodeficiencies
0.000 0.322 0.678
E02 Subclinical iodine-deficiency hypothyroidism
0.030 0.324 0.646
E05.5 Thyroid crisis or storm
0.005 0.326 0.669
E05.4 Thyrotoxicosis factitia
0.005 0.326 0.669
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.005 0.326 0.669
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.005 0.326 0.669
D74 Methaemoglobinaemia
0.000 0.333 0.667
D77 Other disorders of blood and blood-forming organs in diseases classified elsewhere
0.000 0.333 0.667
D71 Functional disorders of polymorphonuclear neutrophils
0.000 0.333 0.667
D53.9 Nutritional anaemia, unspecified
0.000 0.347 0.653
D82 Immunodeficiency associated with other major defects
0.000 0.351 0.649
E14.3 With ophthalmic complications
0.000 0.359 0.641
D80.1 Nonfamilial hypogammaglobulinaemia
0.000 0.361 0.639
E05.8 Other thyrotoxicosis
0.005 0.367 0.627
D59.9 Acquired haemolytic anaemia, unspecified
0.000 0.375 0.625
E51 Thiamine deficiency
0.000 0.382 0.618
D75.0 Familial erythrocytosis
0.000 0.391 0.609
D83.9 Common variable immunodeficiency, unspecified
0.000 0.397 0.603
D76 Certain diseases involving lymphoreticular tissue and reticulohistiocytic system
0.000 0.397 0.603
D51.8 Other vitamin B12 deficiency anaemias
0.000 0.399 0.601
D51.3 Other dietary vitamin B12 deficiency anaemia
0.000 0.399 0.601
D51.2 Transcobalamin II deficiency
0.000 0.399 0.601
D51.1 Vitamin B12 deficiency anaemia due to selective vitamin B12 malabsorption with proteinuria
0.000 0.399 0.601
D80.2 Selective deficiency of immunoglobulin A [IgA]
0.000 0.399 0.601
D72.9 Disorder of white blood cells, unspecified
0.000 0.399 0.601
D72.0 Genetic anomalies of leukocytes
0.000 0.399 0.601
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.399 0.601
E63 Other nutritional deficiencies
0.000 0.399 0.601
E50 Vitamin A deficiency
0.000 0.399 0.601
E60 Dietary zinc deficiency
0.000 0.399 0.601
E59 Dietary selenium deficiency
0.000 0.399 0.601
E52 Niacin deficiency [pellagra]
0.000 0.399 0.601
E14.8 With unspecified complications
0.000 0.404 0.596
D80.3 Selective deficiency of immunoglobulin G [IgG] subclasses
0.000 0.406 0.594
E53 Deficiency of other B group vitamins
0.000 0.409 0.591
D59.1 Other autoimmune haemolytic anaemias
0.000 0.411 0.589
E14.1 With ketoacidosis
0.000 0.419 0.581
E14.6 With other specified complications
0.000 0.420 0.580
E06.9 Thyroiditis, unspecified
0.009 0.421 0.570
E54 Ascorbic acid deficiency
0.000 0.424 0.576
D69 Purpura and other haemorrhagic conditions
0.000 0.424 0.576
D72.1 Eosinophilia
0.000 0.425 0.574
D66 Hereditary factor VIII deficiency
0.000 0.426 0.574
D84 Other immunodeficiencies
0.000 0.428 0.572
E55.0 Rickets, active
0.000 0.429 0.570
D65 Disseminated intravascular coagulation [defibrination syndrome]
0.000 0.434 0.565
E83.1 Disorders of iron metabolism
0.000 0.441 0.559
D75.2 Essential thrombocytosis
0.000 0.441 0.559
E58 Dietary calcium deficiency
0.000 0.448 0.552
D80.8 Other immunodeficiencies with predominantly antibody defects
0.000 0.449 0.550
D80.7 Transient hypogammaglobulinaemia of infancy
0.000 0.449 0.550
D80.6 Antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinaemia
0.000 0.449 0.550
D80.5 Immunodeficiency with increased immunoglobulin M [IgM]
0.000 0.449 0.550
D80.0 Hereditary hypogammaglobulinaemia
0.000 0.449 0.550
E03.5 Myxoedema coma
0.304 0.451 0.245
E03.4 Atrophy of thyroid (acquired)
0.304 0.451 0.245
E03.3 Postinfectious hypothyroidism
0.304 0.451 0.245
E56 Other vitamin deficiencies
0.000 0.453 0.546
E07 Other disorders of thyroid
0.055 0.457 0.488
D89 Other disorders involving the immune mechanism, not elsewhere classified
0.000 0.459 0.541
E03.0 Congenital hypothyroidism with diffuse goitre
0.301 0.460 0.239
E14.7 With multiple complications
0.000 0.461 0.539
E14.2 Withrenal complications
0.000 0.461 0.539
E14.0 With coma
0.000 0.461 0.539
D83.8 Other common variable immunodeficiencies
0.000 0.465 0.535
D83.2 Common variable immunodeficiency with autoantibodies to B- or T-cells
0.000 0.465 0.535
D83.1 Common variable immunodeficiency with predominant immunoregulatory T-cell disorders
0.000 0.465 0.535
D83.0 Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function
0.000 0.465 0.535
D53.8 Other specified nutritional anaemias
0.000 0.466 0.534
D53.2 Scorbutic anaemia
0.000 0.466 0.534
D53.1 Other megaloblastic anaemias, not elsewhere classified
0.000 0.466 0.534
D53.0 Protein deficiency anaemia
0.000 0.466 0.534
D55 Anaemia due to enzyme disorders
0.000 0.468 0.532
E65-E68 Obesity and other hyperalimentation
0.000 0.469 0.531
E03.1 Congenital hypothyroidism without goitre
0.269 0.470 0.262
E70-E90 Metabolic disorders
0.000 0.476 0.524
E05.9 Thyrotoxicosis, unspecified
0.000 0.479 0.521
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.005 0.479 0.516
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.316 0.480 0.205
E14.5 With peripheral circulatory complications
0.000 0.480 0.520
D67 Hereditary factor IX deficiency
0.000 0.483 0.517
E83 Disorders of mineral metabolism
0.000 0.484 0.516
D50 Iron deficiency anaemia
0.000 0.485 0.515
E12.9 Without complications
0.000 0.486 0.514
E12.8 With unspecified complications
0.000 0.486 0.514
E12.7 With multiple complications
0.000 0.486 0.514
E12.6 With other specified complications
0.000 0.486 0.514
E12.5 With peripheral circulatory complications
0.000 0.486 0.514
E12.4 With neurological complications
0.000 0.486 0.514
E12.3 With ophthalmic complications
0.000 0.486 0.514
E12.2 With renal complications
0.000 0.486 0.514
E12.1 With ketoacidosis
0.000 0.486 0.514
E12.0 With coma
0.000 0.486 0.514
D80.9 Immunodeficiency with predominantly antibody defects, unspecified
0.000 0.486 0.513
D75.8 Other specified diseases of blood and blood-forming organs
0.000 0.486 0.513
E13.9 Without complications
0.000 0.488 0.512
D57 Sickle-cell disorders
0.000 0.493 0.507
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.497 0.503
E45 Retarded development following protein-energy malnutrition
0.000 0.497 0.503
E43 Unspecified severe protein-energy malnutrition
0.000 0.497 0.503
E42 Marasmic kwashiorkor
0.000 0.497 0.503
E41 Nutritional marasmus
0.000 0.497 0.503
E40 Kwashiorkor
0.000 0.497 0.503
L40.8 Other psoriasis
0.000 0.497 0.502
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.022 0.497 0.481
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.022 0.497 0.481
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.022 0.497 0.481
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.022 0.497 0.481
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.022 0.497 0.481
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.022 0.497 0.481
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.022 0.497 0.481
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.022 0.497 0.481
D59.8 Other acquired haemolytic anaemias
0.000 0.503 0.497
D59.6 Haemoglobinuria due to haemolysis from other external causes
0.000 0.503 0.497
D59.5 Paroxysmal nocturnal haemoglobinuria [Marchiafava-Micheli]
0.000 0.503 0.497
D59.4 Other nonautoimmune haemolytic anaemias
0.000 0.503 0.497
D59.3 Haemolytic-uraemic syndrome
0.000 0.503 0.497
D59.2 Drug-induced nonautoimmune haemolytic anaemia
0.000 0.503 0.497
D59.0 Drug-induced autoimmune haemolytic anaemia
0.000 0.503 0.497
E13.8 With unspecified complications
0.000 0.505 0.495
E13.7 With multiple complications
0.000 0.505 0.495
E13.6 With other specified complications
0.000 0.505 0.495
E13.5 With peripheral circulatory complications
0.000 0.505 0.495
E13.4 With neurological complications
0.000 0.505 0.495
E13.2 With renal complications
0.000 0.505 0.495
E13.1 With ketoacidosis
0.000 0.505 0.495
E13.0 With coma
0.000 0.505 0.495
E14.4 With neurological complications
0.000 0.505 0.495
D69.6 Thrombocytopenia, unspecified
0.000 0.505 0.495
D75.1 Secondary polycythaemia
0.000 0.508 0.492
E06.4 Drug-induced thyroiditis
0.016 0.510 0.474
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.016 0.510 0.474
E06.0 Acute thyroiditis
0.016 0.510 0.474
E46 Unspecified protein-energy malnutrition
0.000 0.511 0.489
E03.8 Other specified hypothyroidism
0.273 0.512 0.216
D81.9 Combined immunodeficiency, unspecified
0.000 0.513 0.486
D81.8 Other combined immunodeficiencies
0.000 0.513 0.486
D81.7 Major histocompatibility complex class II deficiency
0.000 0.513 0.486
D81.6 Major histocompatibility complex class I deficiency
0.000 0.513 0.486
D81.5 Purine nucleoside phosphorylase [PNP] deficiency
0.000 0.513 0.486
D81.4 Nezelof's syndrome
0.000 0.513 0.486
D81.3 Adenosine deaminase [ADA] deficiency
0.000 0.513 0.486
D81.2 Severe combined immunodeficiency [SCID] with low or normal B-cell numbers
0.000 0.513 0.486
D81.1 Severe combined immunodeficiency [SCID] with low T- and B-cell numbers
0.000 0.513 0.486
D81.0 Severe combined immunodeficiency [SCID] with reticular dysgenesis
0.000 0.513 0.486
D69.2 Other nonthrombocytopenic purpura
0.000 0.520 0.480
D74.9 Methaemoglobinaemia, unspecified
0.000 0.522 0.478
D74.8 Other methaemoglobinaemias
0.000 0.522 0.478
D74.0 Congenital methaemoglobinaemia
0.000 0.522 0.478
E88 Other metabolic disorders
0.000 0.526 0.474
E04 Other non-toxic goitre
0.003 0.527 0.470
D69.5 Secondary thrombocytopenia
0.000 0.528 0.472
D58 Other hereditary haemolytic anaemias
0.000 0.530 0.470
E06.3 Autoimmune thyroiditis
0.008 0.532 0.460
D80.4 Selective deficiency of immunoglobulin M [IgM]
0.000 0.534 0.466
D82.9 Immunodeficiency associated with major defect, unspecified
0.000 0.535 0.465
D82.8 Immunodeficiency associated with other specified major defects
0.000 0.535 0.465
D82.4 Hyperimmunoglobulin E [IgE] syndrome
0.000 0.535 0.465
D82.3 Immunodeficiency following hereditary defective response to Epstein-Barr virus
0.000 0.535 0.465
D82.2 Immunodeficiency with short-limbed stature
0.000 0.535 0.465
D82.0 Wiskott-Aldrich syndrome
0.000 0.535 0.465
E51.2 Wernicke's encephalopathy
0.000 0.539 0.460
E85 Amyloidosis
0.000 0.545 0.455
E53.9 Vitamin B deficiency, unspecified
0.000 0.546 0.453
E13.3 With ophthalmic complications
0.000 0.552 0.448
D84.1 Defects in the complement system
0.000 0.553 0.447
E51.9 Thiamine deficiency, unspecified
0.000 0.557 0.443
E51.8 Other manifestations of thiamine deficiency
0.000 0.557 0.443
E51.1 Beriberi
0.000 0.557 0.443
K90 Intestinal malabsorption
0.000 0.559 0.441
E20-E35 Disorders of other endocrine glands
0.000 0.561 0.439
D82.1 Di George's syndrome
0.000 0.564 0.436
D76.2 Haemophagocytic syndrome, infection-associated
0.000 0.567 0.432
D76.1 Haemophagocytic lymphohistiocytosis
0.000 0.567 0.432
D76.0 Langerhans' cell histiocytosis, not elsewhere classified
0.000 0.567 0.432
E88.0 Disorders of plasma-protein metabolism, not elsewhere classified
0.000 0.568 0.432
D50.9 Iron deficiency anaemia, unspecified
0.000 0.569 0.431
E61 Deficiency of other nutrient elements
0.000 0.569 0.431
E50.9 Vitamin A deficiency, unspecified
0.000 0.569 0.431
E50.8 Other manifestations of vitamin A deficiency
0.000 0.569 0.431
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.569 0.431
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.569 0.431
E50.5 Vitamin A deficiency with night blindness
0.000 0.569 0.431
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.569 0.431
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.569 0.431
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.569 0.431
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.569 0.431
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.569 0.431
E63.9 Nutritional deficiency, unspecified
0.000 0.569 0.431
E63.8 Other specified nutritional deficiencies
0.000 0.569 0.431
E63.1 Imbalance of constituents of food intake
0.000 0.569 0.431
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.569 0.431
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.569 0.431
E64.8 Sequelae of other nutritional deficiencies
0.000 0.569 0.431
E64.3 Sequelae of rickets
0.000 0.569 0.431
E64.2 Sequelae of vitamin C deficiency
0.000 0.569 0.431
E64.1 Sequelae of vitamin A deficiency
0.000 0.569 0.431
E64.0 Sequelae of protein-energy malnutrition
0.000 0.569 0.431
E27.1 Primary adrenocortical insufficiency
0.000 0.570 0.430
E11.2 With renal complications
0.000 0.571 0.429
E27 Other disorders of adrenal gland
0.000 0.572 0.428
D52 Folate deficiency anaemia
0.000 0.572 0.428
E11.0 With coma
0.000 0.573 0.427
E06.1 Subacute thyroiditis
0.018 0.575 0.407
E53.1 Pyridoxine deficiency
0.000 0.576 0.424
E53.0 Riboflavin deficiency
0.000 0.576 0.424
D69.3 Idiopathic thrombocytopenic purpura
0.000 0.576 0.424
D69.9 Haemorrhagic condition, unspecified
0.000 0.577 0.423
E07.8 Other specified disorders of thyroid
0.028 0.581 0.392
D69.8 Other specified haemorrhagic conditions
0.000 0.587 0.413
D89.8 Other specified disorders involving the immune mechanism, not elsewhere classified
0.000 0.589 0.410
D84.8 Other specified immunodeficiencies
0.000 0.590 0.410
D84.0 Lymphocyte function antigen-1 [LFA-1] defect
0.000 0.590 0.410
E06.5 Other chronic thyroiditis
0.018 0.596 0.386
E85.4 Organ-limited amyloidosis
0.000 0.597 0.403
D89.9 Disorder involving the immune mechanism, unspecified
0.000 0.599 0.401
E79 Disorders of purine and pyrimidine metabolism
0.000 0.605 0.395
E56.9 Vitamin deficiency, unspecified
0.000 0.608 0.392
E56.8 Deficiency of other vitamins
0.000 0.608 0.392
E56.0 Deficiency of vitamin E
0.000 0.608 0.392
E04.0 Non-toxic diffuse goitre
0.001 0.608 0.390
D69.1 Qualitative platelet defects
0.000 0.610 0.390
E70 Disorders of aromatic amino-acid metabolism
0.000 0.610 0.390
E07.1 Dyshormogenetic goitre
0.040 0.611 0.350
E07.0 Hypersecretion of calcitonin
0.040 0.611 0.350
D89.3 Immune reconstitution syndrome
0.000 0.612 0.388
D55.9 Anaemia due to enzyme disorder, unspecified
0.000 0.618 0.381
D55.8 Other anaemias due to enzyme disorders
0.000 0.618 0.381
D55.3 Anaemia due to disorders of nucleotide metabolism
0.000 0.618 0.381
D55.2 Anaemia due to disorders of glycolytic enzymes
0.000 0.618 0.381
D55.1 Anaemia due to other disorders of glutathione metabolism
0.000 0.618 0.381
D55.0 Anaemia due to glucose-6-phosphate dehydrogenase [G6PD] deficiency
0.000 0.618 0.381
E88.1 Lipodystrophy, not elsewhere classified
0.000 0.619 0.381
E67 Other hyperalimentation
0.000 0.619 0.380
E68 Sequelae of hyperalimentation
0.000 0.619 0.380
E77 Disorders of glycoprotein metabolism
0.000 0.624 0.376
E76 Disorders of glycosaminoglycan metabolism
0.000 0.624 0.376
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.000 0.624 0.376
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.000 0.624 0.376
E53.8 Deficiency of other specified B group vitamins
0.000 0.624 0.376
E34 Other endocrine disorders
0.000 0.626 0.374
D89.1 Cryoglobulinaemia
0.000 0.627 0.373
E88.9 Metabolic disorder, unspecified
0.000 0.629 0.371
E83.8 Other disorders of mineral metabolism
0.000 0.630 0.370
E83.2 Disorders of zinc metabolism
0.000 0.630 0.370
E83.0 Disorders of copper metabolism
0.000 0.630 0.370
D50.1 Sideropenic dysphagia
0.000 0.631 0.369
D76.3 Other histiocytosis syndromes
0.000 0.631 0.368
D57.8 Other sickle-cell disorders
0.000 0.636 0.363
D57.3 Sickle-cell trait
0.000 0.636 0.363
D57.2 Double heterozygous sickling disorders
0.000 0.636 0.363
D57.0 Sickle-cell anaemia with crisis
0.000 0.636 0.363
D69.4 Other primary thrombocytopenia
0.000 0.637 0.363
E44.1 Mild protein-energy malnutrition
0.000 0.639 0.361
E44.0 Moderate protein-energy malnutrition
0.000 0.639 0.361
E04.9 Non-toxic goitre, unspecified
0.000 0.642 0.357
E83.9 Disorder of mineral metabolism, unspecified
0.000 0.645 0.355
K90.9 Intestinal malabsorption, unspecified
0.000 0.647 0.353
E84 Cystic fibrosis
0.000 0.648 0.352
D50.8 Other iron deficiency anaemias
0.000 0.651 0.349
D58.2 Other haemoglobinopathies
0.000 0.652 0.348
E66 Obesity
0.000 0.654 0.346
E72 Other disorders of amino-acid metabolism
0.000 0.655 0.345
E85.3 Secondary systemic amyloidosis
0.000 0.656 0.344
E20 Hypoparathyroidism
0.000 0.657 0.343
D56 Thalassaemia
0.001 0.660 0.339
E04.8 Other specified non-toxic goitre
0.002 0.661 0.337
D57.1 Sickle-cell anaemia without crisis
0.000 0.662 0.338
E88.3 Tumour lysis syndrome
0.000 0.662 0.338
E34.9 Endocrine disorder, unspecified
0.000 0.662 0.338
E56.1 Deficiency of vitamin K
0.000 0.662 0.337
D58.8 Other specified hereditary haemolytic anaemias
0.000 0.663 0.337
D58.1 Hereditary elliptocytosis
0.000 0.663 0.337
E27.3 Drug-induced adrenocortical insufficiency
0.000 0.671 0.328
E85.8 Other amyloidosis
0.000 0.673 0.326
E85.2 Heredofamilial amyloidosis, unspecified
0.000 0.673 0.326
E85.1 Neuropathic heredofamilial amyloidosis
0.000 0.673 0.326
E85.0 Nonneuropathic heredofamilial amyloidosis
0.000 0.673 0.326
E25 Adrenogenital disorders
0.000 0.675 0.325
E88.8 Other specified metabolic disorders
0.000 0.678 0.322
E74 Other disorders of carbohydrate metabolism
0.000 0.680 0.320
D89.0 Polyclonal hypergammaglobulinaemia
0.000 0.681 0.318
K90.3 Pancreatic steatorrhoea
0.000 0.684 0.316
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.684 0.316
K90.1 Tropical sprue
0.000 0.684 0.316
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.685 0.315
E32 Diseases of thymus
0.000 0.685 0.315
E31 Polyglandular dysfunction
0.000 0.685 0.315
E30 Disorders of puberty, not elsewhere classified
0.000 0.685 0.315
E85.9 Amyloidosis, unspecified
0.000 0.687 0.313
E61.9 Deficiency of nutrient element, unspecified
0.000 0.691 0.309
E61.8 Deficiency of other specified nutrient elements
0.000 0.691 0.309
E61.7 Deficiency of multiple nutrient elements
0.000 0.691 0.309
E61.6 Vanadium deficiency
0.000 0.691 0.309
E61.5 Molybdenum deficiency
0.000 0.691 0.309
E61.4 Chromium deficiency
0.000 0.691 0.309
E61.3 Manganese deficiency
0.000 0.691 0.309
E61.0 Copper deficiency
0.000 0.691 0.309
D58.9 Hereditary haemolytic anaemia, unspecified
0.000 0.692 0.307
D89.2 Hypergammaglobulinaemia, unspecified
0.000 0.692 0.307
E27.5 Adrenomedullary hyperfunction
0.000 0.693 0.307
E27.0 Other adrenocortical overactivity
0.000 0.693 0.307
D52.8 Other folate deficiency anaemias
0.000 0.693 0.307
D52.1 Drug-induced folate deficiency anaemia
0.000 0.693 0.307
D52.0 Dietary folate deficiency anaemia
0.000 0.693 0.307
K90.8 Other intestinal malabsorption
0.000 0.695 0.304
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
0.000 0.698 0.302
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.000 0.698 0.302
E73 Lactose intolerance
0.000 0.698 0.301
E34.0 Carcinoid syndrome
0.000 0.702 0.298
D58.0 Hereditary spherocytosis
0.000 0.703 0.297
E66.2 Extreme obesity with alveolar hypoventilation
0.000 0.705 0.295
E27.2 Addisonian crisis
0.000 0.705 0.295
E70.3 Albinism
0.000 0.706 0.294
E88.2 Lipomatosis, not elsewhere classified
0.000 0.711 0.289
E66.0 Obesity due to excess calories
0.000 0.713 0.287
E79.9 Disorder of purine and pyrimidine metabolism, unspecified
0.000 0.717 0.283
E79.8 Other disorders of purine and pyrimidine metabolism
0.000 0.717 0.283
E79.1 Lesch-Nyhan syndrome
0.000 0.717 0.283
E22 Hyperfunction of pituitary gland
0.000 0.718 0.282
E70.9 Disorder of aromatic amino-acid metabolism, unspecified
0.000 0.720 0.280
E70.8 Other disorders of aromatic amino-acid metabolism
0.000 0.720 0.280
E70.2 Disorders of tyrosine metabolism
0.000 0.720 0.280
E70.1 Other hyperphenylalaninaemias
0.000 0.720 0.280
E70.0 Classical phenylketonuria
0.000 0.720 0.280
S64.4 Injury of digital nerve of other finger
0.280 0.720 0.000
E27.8 Other specified disorders of adrenal gland
0.000 0.720 0.280
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.000 0.723 0.277
E20.9 Hypoparathyroidism, unspecified
0.000 0.726 0.274
E67.8 Other specified hyperalimentation
0.000 0.727 0.273
E67.3 Hypervitaminosis D
0.000 0.727 0.273
E67.2 Megavitamin-B6 syndrome
0.000 0.727 0.273
E67.1 Hypercarotenaemia
0.000 0.727 0.273
E67.0 Hypervitaminosis A
0.000 0.727 0.273
E61.2 Magnesium deficiency
0.000 0.729 0.271
E71.3 Disorders of fatty-acid metabolism
0.000 0.730 0.270
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified
0.000 0.730 0.270
E71.1 Other disorders of branched-chain amino-acid metabolism
0.000 0.730 0.270
E71.0 Maple-syrup-urine disease
0.000 0.730 0.270
E76.9 Disorder of glucosaminoglycan metabolism, unspecified
0.000 0.730 0.270
E76.8 Other disorders of glucosaminoglycan metabolism
0.000 0.730 0.270
E76.3 Mucopolysaccharidosis, unspecified
0.000 0.730 0.270
E76.2 Other mucopolysaccharidoses
0.000 0.730 0.270
E76.1 Mucopolysaccharidosis, type II
0.000 0.730 0.270
E76.0 Mucopolysaccharidosis, type I
0.000 0.730 0.270
E77.9 Disorder of glycoprotein metabolism, unspecified
0.000 0.730 0.270
E77.8 Other disorders of glycoprotein metabolism
0.000 0.730 0.270
E77.1 Defects in glycoprotein degradation
0.000 0.730 0.270
E77.0 Defects in posttranslational modification of lysosomal enzymes
0.000 0.730 0.270
E34.5 Androgen resistance syndrome
0.000 0.732 0.268
E34.4 Constitutional tall stature
0.000 0.732 0.268
E34.2 Ectopic hormone secretion, not elsewhere classified
0.000 0.732 0.268
E34.1 Other hypersecretion of intestinal hormones
0.000 0.732 0.268
E86 Volume depletion
0.000 0.737 0.263
E65 Localised adiposity
0.000 0.742 0.258
E29 Testicular dysfunction
0.000 0.742 0.258
E34.3 Short stature, not elsewhere classified
0.000 0.743 0.257
E24 Cushing's syndrome
0.000 0.744 0.256
E84.8 Cystic fibrosis with other manifestations
0.000 0.747 0.252
E84.1 Cystic fibrosis with intestinal manifestations
0.000 0.747 0.252
E84.0 Cystic fibrosis with pulmonary manifestations
0.000 0.747 0.252
D73 Diseases of spleen
0.000 0.750 0.250
E27.4 Other and unspecified adrenocortical insufficiency
0.000 0.750 0.250
E66.1 Drug-induced obesity
0.000 0.752 0.248
E72.9 Disorder of amino-acid metabolism, unspecified
0.000 0.752 0.248
E72.8 Other specified disorders of amino-acid metabolism
0.000 0.752 0.248
E72.5 Disorders of glycine metabolism
0.000 0.752 0.248
E72.4 Disorders of ornithine metabolism
0.000 0.752 0.248
E72.3 Disorders of lysine and hydroxylysine metabolism
0.000 0.752 0.248
E72.2 Disorders of urea cycle metabolism
0.000 0.752 0.248
E72.1 Disorders of sulphur-bearing amino-acid metabolism
0.000 0.752 0.248
E20.8 Other hypoparathyroidism
0.000 0.754 0.246
E20.1 Pseudohypoparathyroidism
0.000 0.754 0.246
E20.0 Idiopathic hypoparathyroidism
0.000 0.754 0.246
D56.9 Thalassaemia, unspecified
0.001 0.756 0.243
D56.8 Other thalassaemias
0.001 0.756 0.243
D56.4 Hereditary persistence of foetal haemoglobin [HPFH]
0.001 0.756 0.243
D56.2 Delta-beta thalassaemia
0.001 0.756 0.243
D56.0 Alpha thalassaemia
0.001 0.756 0.243
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.000 0.757 0.243
D60-D64 Aplastic and other anaemias
0.000 0.757 0.243
E25.9 Adrenogenital disorder, unspecified
0.000 0.767 0.233
E25.8 Other adrenogenital disorders
0.000 0.767 0.233
E04.1 Non-toxic single thyroid nodule
0.001 0.768 0.232
E74.9 Disorder of carbohydrate metabolism, unspecified
0.000 0.770 0.229
E74.8 Other specified disorders of carbohydrate metabolism
0.000 0.770 0.229
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
0.000 0.770 0.229
E74.2 Disorders of galactose metabolism
0.000 0.770 0.229
E74.1 Disorders of fructose metabolism
0.000 0.770 0.229
E74.0 Glycogen storage disease
0.000 0.770 0.229
E84.9 Cystic fibrosis, unspecified
0.000 0.772 0.228
E30.9 Disorder of puberty, unspecified
0.000 0.774 0.226
E30.8 Other disorders of puberty
0.000 0.774 0.226
E30.1 Precocious puberty
0.000 0.774 0.226
E30.0 Delayed puberty
0.000 0.774 0.226
E31.9 Polyglandular dysfunction, unspecified
0.000 0.774 0.226
E31.8 Other polyglandular dysfunction
0.000 0.774 0.226
E31.1 Polyglandular hyperfunction
0.000 0.774 0.226
E31.0 Autoimmune polyglandular failure
0.000 0.774 0.226
E32.9 Disease of thymus, unspecified
0.000 0.774 0.226
E32.8 Other diseases of thymus
0.000 0.774 0.226
E32.1 Abscess of thymus
0.000 0.774 0.226
E32.0 Persistent hyperplasia of thymus
0.000 0.774 0.226
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.774 0.226
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.774 0.226
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.774 0.226
E22.1 Hyperprolactinaemia
0.000 0.775 0.225
D84.9 Immunodeficiency, unspecified
0.001 0.775 0.224
E66.8 Other obesity
0.000 0.775 0.225
E72.0 Disorders of amino-acid transport
0.000 0.783 0.217
E75.6 Lipid storage disorder, unspecified
0.000 0.783 0.217
E75.4 Neuronal ceroid lipofuscinosis
0.000 0.783 0.217
E75.3 Sphingolipidosis, unspecified
0.000 0.783 0.217
E75.1 Other gangliosidosis
0.000 0.783 0.217
E75.0 GM2 gangliosidosis
0.000 0.783 0.217
E73.8 Other lactose intolerance
0.000 0.784 0.216
E73.1 Secondary lactase deficiency
0.000 0.784 0.216
E73.0 Congenital lactase deficiency
0.000 0.784 0.216
E80 Disorders of porphyrin and bilirubin metabolism
0.000 0.787 0.213

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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