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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs2246986
log Bayes Factor = 6.76058
Chromosome 6   position 31,482,203  (GRCh37) Explore rs2246986 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E03.9 Hypothyroidism, unspecified
0.000 0.000 1.000
E10.9 Without complications
0.000 0.002 0.998
E10 Insulin-dependent diabetes mellitus
0.000 0.002 0.998
E03 Other hypothyroidism
0.000 0.004 0.996
E00-E07 Disorders of thyroid gland
0.000 0.007 0.993
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.016 0.984
E10-E14 Diabetes mellitus
0.000 0.016 0.984
E10.3 With ophthalmic complications
0.000 0.020 0.980
E06 Thyroiditis
0.000 0.061 0.939
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.085 0.915
E06.3 Autoimmune thyroiditis
0.000 0.095 0.905
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.127 0.873
E10.1 With ketoacidosis
0.000 0.129 0.871
E03.8 Other specified hypothyroidism
0.000 0.237 0.763
E40-E46 Malnutrition
0.000 0.239 0.761
E65-E68 Obesity and other hyperalimentation
0.000 0.263 0.737
E70-E90 Metabolic disorders
0.000 0.280 0.720
E10.7 With multiple complications
0.000 0.285 0.715
E10.0 With coma
0.000 0.285 0.715
E03.5 Myxoedema coma
0.000 0.286 0.714
E03.4 Atrophy of thyroid (acquired)
0.000 0.286 0.714
E03.3 Postinfectious hypothyroidism
0.000 0.286 0.714
E03.1 Congenital hypothyroidism without goitre
0.000 0.286 0.714
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.286 0.714
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.288 0.712
E00 Congenital iodine-deficiency syndrome
0.000 0.288 0.712
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.288 0.712
E10.5 With peripheral circulatory complications
0.000 0.289 0.711
E05.9 Thyrotoxicosis, unspecified
0.000 0.293 0.707
E12 Malnutrition-related diabetes mellitus
0.000 0.295 0.705
E10.2 With renal complications
0.000 0.311 0.689
E10.8 With unspecified complications
0.000 0.317 0.683
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.322 0.678
E10.6 With other specified complications
0.000 0.327 0.673
E06.5 Other chronic thyroiditis
0.000 0.327 0.673
E06.4 Drug-induced thyroiditis
0.000 0.327 0.673
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.327 0.673
E06.1 Subacute thyroiditis
0.000 0.327 0.673
E06.0 Acute thyroiditis
0.000 0.327 0.673
E86 Volume depletion
0.000 0.328 0.672
E80 Disorders of porphyrin and bilirubin metabolism
0.000 0.331 0.669
E05.5 Thyroid crisis or storm
0.000 0.344 0.656
E05.4 Thyrotoxicosis factitia
0.000 0.344 0.656
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.344 0.656
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.344 0.656
E10.4 With neurological complications
0.000 0.344 0.656
E20-E35 Disorders of other endocrine glands
0.000 0.352 0.648
E06.9 Thyroiditis, unspecified
0.000 0.368 0.632
E80.4 Gilbert's syndrome
0.000 0.368 0.632
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.377 0.623
E65 Localised adiposity
0.000 0.390 0.610
E46 Unspecified protein-energy malnutrition
0.000 0.398 0.602
E73 Lactose intolerance
0.000 0.401 0.598
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.411 0.589
E27 Other disorders of adrenal gland
0.000 0.422 0.578
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.454 0.546
E45 Retarded development following protein-energy malnutrition
0.000 0.454 0.546
E43 Unspecified severe protein-energy malnutrition
0.000 0.454 0.546
E42 Marasmic kwashiorkor
0.000 0.454 0.546
E41 Nutritional marasmus
0.000 0.454 0.546
E40 Kwashiorkor
0.000 0.454 0.546
E28 Ovarian dysfunction
0.000 0.457 0.543
E05.8 Other thyrotoxicosis
0.000 0.461 0.539
E27.1 Primary adrenocortical insufficiency
0.000 0.461 0.539
E88 Other metabolic disorders
0.000 0.471 0.529
E67 Other hyperalimentation
0.000 0.472 0.528
E68 Sequelae of hyperalimentation
0.000 0.472 0.528
E84 Cystic fibrosis
0.000 0.483 0.516
E79 Disorders of purine and pyrimidine metabolism
0.000 0.483 0.516
E77 Disorders of glycoprotein metabolism
0.000 0.483 0.516
E76 Disorders of glycosaminoglycan metabolism
0.000 0.483 0.516
E72 Other disorders of amino-acid metabolism
0.000 0.483 0.516
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.000 0.483 0.516
E70 Disorders of aromatic amino-acid metabolism
0.000 0.483 0.516
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.000 0.483 0.516
E13 Other specified diabetes mellitus
0.001 0.485 0.514
E73.9 Lactose intolerance, unspecified
0.000 0.489 0.511
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.000 0.489 0.511
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.000 0.489 0.511
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.000 0.489 0.511
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.000 0.489 0.511
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.489 0.511
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.000 0.489 0.511
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.000 0.489 0.511
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.000 0.489 0.511
E50-E64 Other nutritional deficiencies
0.000 0.491 0.508
E12.9 Without complications
0.000 0.494 0.506
E12.8 With unspecified complications
0.000 0.494 0.506
E12.7 With multiple complications
0.000 0.494 0.506
E12.6 With other specified complications
0.000 0.494 0.506
E12.5 With peripheral circulatory complications
0.000 0.494 0.506
E12.4 With neurological complications
0.000 0.494 0.506
E12.3 With ophthalmic complications
0.000 0.494 0.506
E12.2 With renal complications
0.000 0.494 0.506
E12.1 With ketoacidosis
0.000 0.494 0.506
E12.0 With coma
0.000 0.494 0.506
E07 Other disorders of thyroid
0.001 0.515 0.484
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.000 0.516 0.484
E80.7 Disorder of bilirubin metabolism, unspecified
0.000 0.520 0.479
E80.6 Other disorders of bilirubin metabolism
0.000 0.520 0.479
E80.5 Crigler-Najjar syndrome
0.000 0.520 0.479
E80.3 Defects of catalase and peroxydase
0.000 0.520 0.479
E80.2 Other porphyria
0.000 0.520 0.479
E80.1 Porphyria cutanea tarda
0.000 0.520 0.479
E80.0 Hereditary erythropoietic porphyria
0.000 0.520 0.479
E74 Other disorders of carbohydrate metabolism
0.000 0.521 0.479
E20 Hypoparathyroidism
0.000 0.521 0.479
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.000 0.527 0.473
E28.2 Polycystic ovarian syndrome
0.000 0.532 0.468
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.535 0.465
E32 Diseases of thymus
0.000 0.535 0.465
E31 Polyglandular dysfunction
0.000 0.535 0.465
E30 Disorders of puberty, not elsewhere classified
0.000 0.535 0.465
E25 Adrenogenital disorders
0.000 0.535 0.465
E24 Cushing's syndrome
0.000 0.536 0.464
E26 Hyperaldosteronism
0.000 0.546 0.454
E14 Unspecified diabetes mellitus
0.000 0.553 0.447
E66 Obesity
0.000 0.553 0.447
E27.8 Other specified disorders of adrenal gland
0.000 0.564 0.435
E27.9 Disorder of adrenal gland, unspecified
0.000 0.568 0.432
E73.8 Other lactose intolerance
0.000 0.571 0.429
E73.1 Secondary lactase deficiency
0.000 0.571 0.429
E73.0 Congenital lactase deficiency
0.000 0.571 0.429
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.000 0.571 0.429
E89.0 Postprocedural hypothyroidism
0.000 0.576 0.424
E15 Nondiabetic hypoglycaemic coma
0.000 0.578 0.422
E88.0 Disorders of plasma-protein metabolism, not elsewhere classified
0.000 0.578 0.422
E66.8 Other obesity
0.000 0.581 0.419
E27.5 Adrenomedullary hyperfunction
0.000 0.586 0.414
E27.2 Addisonian crisis
0.000 0.586 0.414
E27.0 Other adrenocortical overactivity
0.000 0.586 0.414
E22 Hyperfunction of pituitary gland
0.000 0.605 0.395
E44.1 Mild protein-energy malnutrition
0.000 0.608 0.391
E44.0 Moderate protein-energy malnutrition
0.000 0.608 0.391
E28.9 Ovarian dysfunction, unspecified
0.000 0.610 0.389
E28.8 Other ovarian dysfunction
0.000 0.610 0.389
E28.1 Androgen excess
0.000 0.610 0.389
E28.0 Oestrogen excess
0.000 0.610 0.389
E28.3 Primary ovarian failure
0.000 0.612 0.388
E88.9 Metabolic disorder, unspecified
0.000 0.621 0.379
E88.8 Other specified metabolic disorders
0.000 0.621 0.379
E88.3 Tumour lysis syndrome
0.000 0.621 0.379
E88.1 Lipodystrophy, not elsewhere classified
0.000 0.621 0.379
E67.8 Other specified hyperalimentation
0.000 0.621 0.379
E67.3 Hypervitaminosis D
0.000 0.621 0.379
E67.2 Megavitamin-B6 syndrome
0.000 0.621 0.379
E67.1 Hypercarotenaemia
0.000 0.621 0.379
E67.0 Hypervitaminosis A
0.000 0.621 0.379
E34 Other endocrine disorders
0.000 0.621 0.378
E29 Testicular dysfunction
0.000 0.622 0.378
E27.4 Other and unspecified adrenocortical insufficiency
0.000 0.622 0.378
E21.3 Hyperparathyroidism, unspecified
0.000 0.624 0.376
E70.9 Disorder of aromatic amino-acid metabolism, unspecified
0.000 0.629 0.370
E70.8 Other disorders of aromatic amino-acid metabolism
0.000 0.629 0.370
E70.3 Albinism
0.000 0.629 0.370
E70.2 Disorders of tyrosine metabolism
0.000 0.629 0.370
E70.1 Other hyperphenylalaninaemias
0.000 0.629 0.370
E70.0 Classical phenylketonuria
0.000 0.629 0.370
E71.3 Disorders of fatty-acid metabolism
0.000 0.629 0.370
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified
0.000 0.629 0.370
E71.1 Other disorders of branched-chain amino-acid metabolism
0.000 0.629 0.370
E71.0 Maple-syrup-urine disease
0.000 0.629 0.370
E72.9 Disorder of amino-acid metabolism, unspecified
0.000 0.629 0.370
E72.8 Other specified disorders of amino-acid metabolism
0.000 0.629 0.370
E72.5 Disorders of glycine metabolism
0.000 0.629 0.370
E72.4 Disorders of ornithine metabolism
0.000 0.629 0.370
E72.3 Disorders of lysine and hydroxylysine metabolism
0.000 0.629 0.370
E72.2 Disorders of urea cycle metabolism
0.000 0.629 0.370
E72.1 Disorders of sulphur-bearing amino-acid metabolism
0.000 0.629 0.370
E72.0 Disorders of amino-acid transport
0.000 0.629 0.370
E76.9 Disorder of glucosaminoglycan metabolism, unspecified
0.000 0.629 0.370
E76.8 Other disorders of glucosaminoglycan metabolism
0.000 0.629 0.370
E76.3 Mucopolysaccharidosis, unspecified
0.000 0.629 0.370
E76.2 Other mucopolysaccharidoses
0.000 0.629 0.370
E76.1 Mucopolysaccharidosis, type II
0.000 0.629 0.370
E76.0 Mucopolysaccharidosis, type I
0.000 0.629 0.370
E77.9 Disorder of glycoprotein metabolism, unspecified
0.000 0.629 0.370
E77.8 Other disorders of glycoprotein metabolism
0.000 0.629 0.370
E77.1 Defects in glycoprotein degradation
0.000 0.629 0.370
E77.0 Defects in posttranslational modification of lysosomal enzymes
0.000 0.629 0.370
E79.9 Disorder of purine and pyrimidine metabolism, unspecified
0.000 0.629 0.370
E79.8 Other disorders of purine and pyrimidine metabolism
0.000 0.629 0.370
E79.1 Lesch-Nyhan syndrome
0.000 0.629 0.370
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
0.000 0.629 0.370
E84.9 Cystic fibrosis, unspecified
0.000 0.629 0.370
E84.8 Cystic fibrosis with other manifestations
0.000 0.629 0.370
E84.1 Cystic fibrosis with intestinal manifestations
0.000 0.629 0.370
E84.0 Cystic fibrosis with pulmonary manifestations
0.000 0.629 0.370
E13.8 With unspecified complications
0.001 0.631 0.369
E13.7 With multiple complications
0.001 0.631 0.369
E13.6 With other specified complications
0.001 0.631 0.369
E13.5 With peripheral circulatory complications
0.001 0.631 0.369
E13.4 With neurological complications
0.001 0.631 0.369
E13.3 With ophthalmic complications
0.001 0.631 0.369
E13.2 With renal complications
0.001 0.631 0.369
E13.1 With ketoacidosis
0.001 0.631 0.369
E13.0 With coma
0.001 0.631 0.369
E53 Deficiency of other B group vitamins
0.000 0.633 0.366
E85 Amyloidosis
0.000 0.634 0.366
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.635 0.365
E63 Other nutritional deficiencies
0.000 0.635 0.365
E56 Other vitamin deficiencies
0.000 0.635 0.365
E51 Thiamine deficiency
0.000 0.635 0.365
E50 Vitamin A deficiency
0.000 0.635 0.365
E60 Dietary zinc deficiency
0.000 0.635 0.365
E59 Dietary selenium deficiency
0.000 0.635 0.365
E58 Dietary calcium deficiency
0.000 0.635 0.365
E54 Ascorbic acid deficiency
0.000 0.635 0.365
E52 Niacin deficiency [pellagra]
0.000 0.635 0.365
E04 Other non-toxic goitre
0.000 0.638 0.362
E20.9 Hypoparathyroidism, unspecified
0.000 0.643 0.357
E27.3 Drug-induced adrenocortical insufficiency
0.000 0.649 0.351
E83 Disorders of mineral metabolism
0.000 0.651 0.349
E07.1 Dyshormogenetic goitre
0.001 0.652 0.347
E07.0 Hypersecretion of calcitonin
0.001 0.652 0.347
E89.9 Postprocedural endocrine and metabolic disorder, unspecified
0.000 0.653 0.347
E89.8 Other postprocedural endocrine and metabolic disorders
0.000 0.653 0.347
E89.5 Postprocedural testicular hypofunction
0.000 0.653 0.347
E89.4 Postprocedural ovarian failure
0.000 0.653 0.347
E89.1 Postprocedural hypoinsulinaemia
0.000 0.653 0.347
E07.8 Other specified disorders of thyroid
0.000 0.656 0.344
E74.9 Disorder of carbohydrate metabolism, unspecified
0.000 0.656 0.344
E74.8 Other specified disorders of carbohydrate metabolism
0.000 0.656 0.344
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
0.000 0.656 0.344
E74.2 Disorders of galactose metabolism
0.000 0.656 0.344
E74.1 Disorders of fructose metabolism
0.000 0.656 0.344
E74.0 Glycogen storage disease
0.000 0.656 0.344
E20.8 Other hypoparathyroidism
0.000 0.657 0.343
E20.1 Pseudohypoparathyroidism
0.000 0.657 0.343
E20.0 Idiopathic hypoparathyroidism
0.000 0.657 0.343
E23 Hypofunction and other disorders of pituitary gland
0.000 0.657 0.343
E89.3 Postprocedural hypopituitarism
0.000 0.659 0.340
E75.6 Lipid storage disorder, unspecified
0.000 0.660 0.339
E75.4 Neuronal ceroid lipofuscinosis
0.000 0.660 0.339
E75.3 Sphingolipidosis, unspecified
0.000 0.660 0.339
E75.2 Other sphingolipidosis
0.000 0.660 0.339
E75.1 Other gangliosidosis
0.000 0.660 0.339
E75.0 GM2 gangliosidosis
0.000 0.660 0.339
E88.2 Lipomatosis, not elsewhere classified
0.000 0.663 0.337
E25.9 Adrenogenital disorder, unspecified
0.000 0.666 0.333
E25.8 Other adrenogenital disorders
0.000 0.666 0.333
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.000 0.666 0.333
E30.9 Disorder of puberty, unspecified
0.000 0.666 0.333
E30.8 Other disorders of puberty
0.000 0.666 0.333
E30.1 Precocious puberty
0.000 0.666 0.333
E30.0 Delayed puberty
0.000 0.666 0.333
E31.9 Polyglandular dysfunction, unspecified
0.000 0.666 0.333
E31.8 Other polyglandular dysfunction
0.000 0.666 0.333
E31.1 Polyglandular hyperfunction
0.000 0.666 0.333
E31.0 Autoimmune polyglandular failure
0.000 0.666 0.333
E32.9 Disease of thymus, unspecified
0.000 0.666 0.333
E32.8 Other diseases of thymus
0.000 0.666 0.333
E32.1 Abscess of thymus
0.000 0.666 0.333
E32.0 Persistent hyperplasia of thymus
0.000 0.666 0.333
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.666 0.333
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.666 0.333
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.666 0.333
E24.8 Other Cushing's syndrome
0.000 0.667 0.333
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.000 0.667 0.333
E24.3 Ectopic ACTH syndrome
0.000 0.667 0.333
E24.2 Drug-induced Cushing's syndrome
0.000 0.667 0.333
E24.1 Nelson's syndrome
0.000 0.667 0.333
E24.0 Pituitary-dependent Cushing's disease
0.000 0.667 0.333
E24.9 Cushing's syndrome, unspecified
0.000 0.668 0.331
E26.9 Hyperaldosteronism, unspecified
0.000 0.674 0.326
E26.8 Other hyperaldosteronism
0.000 0.674 0.326
E26.1 Secondary hyperaldosteronism
0.000 0.674 0.326
E87 Other disorders of fluid, electrolyte and acid-base balance
0.000 0.675 0.325
E89.6 Postprocedural adrenocortical(-medullary) hypofunction
0.000 0.676 0.324
E22.0 Acromegaly and pituitary gigantism
0.000 0.678 0.322
E14.8 With unspecified complications
0.000 0.679 0.321
E14.7 With multiple complications
0.000 0.679 0.321
E14.6 With other specified complications
0.000 0.679 0.321
E14.5 With peripheral circulatory complications
0.000 0.679 0.321
E14.4 With neurological complications
0.000 0.679 0.321
E14.1 With ketoacidosis
0.000 0.679 0.321
E14.0 With coma
0.000 0.679 0.321
E66.1 Drug-induced obesity
0.000 0.679 0.320
E26.0 Primary hyperaldosteronism
0.000 0.685 0.315
E61 Deficiency of other nutrient elements
0.000 0.689 0.311
E83.3 Disorders of phosphorus metabolism
0.000 0.691 0.309
E21.5 Disorder of parathyroid gland, unspecified
0.000 0.692 0.308
E21.4 Other specified disorders of parathyroid gland
0.000 0.692 0.308
E21.2 Other hyperparathyroidism
0.000 0.692 0.308
E74.3 Other disorders of intestinal carbohydrate absorption
0.000 0.693 0.306
E16 Other disorders of pancreatic internal secretion
0.000 0.694 0.306
E04.0 Non-toxic diffuse goitre
0.000 0.696 0.303
E14.3 With ophthalmic complications
0.000 0.698 0.302
E66.0 Obesity due to excess calories
0.000 0.702 0.298
E75.5 Other lipid storage disorders
0.000 0.703 0.296
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.717 0.283
E22.8 Other hyperfunction of pituitary gland
0.000 0.717 0.283
E14.2 Withrenal complications
0.000 0.718 0.282
E87.7 Fluid overload
0.000 0.724 0.276
E85.4 Organ-limited amyloidosis
0.000 0.725 0.274
E53.8 Deficiency of other specified B group vitamins
0.000 0.727 0.273
E34.5 Androgen resistance syndrome
0.000 0.728 0.271
E34.4 Constitutional tall stature
0.000 0.728 0.271
E34.3 Short stature, not elsewhere classified
0.000 0.728 0.271
E34.2 Ectopic hormone secretion, not elsewhere classified
0.000 0.728 0.271
E34.1 Other hypersecretion of intestinal hormones
0.000 0.728 0.271
E29.9 Testicular dysfunction, unspecified
0.000 0.729 0.271
E29.8 Other testicular dysfunction
0.000 0.729 0.271
E29.0 Testicular hyperfunction
0.000 0.729 0.271
E53.1 Pyridoxine deficiency
0.000 0.737 0.263
E53.0 Riboflavin deficiency
0.000 0.737 0.263
E85.2 Heredofamilial amyloidosis, unspecified
0.000 0.737 0.262
E85.1 Neuropathic heredofamilial amyloidosis
0.000 0.737 0.262
E85.0 Nonneuropathic heredofamilial amyloidosis
0.000 0.737 0.262
E50.9 Vitamin A deficiency, unspecified
0.000 0.738 0.261
E50.8 Other manifestations of vitamin A deficiency
0.000 0.738 0.261
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.738 0.261
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.738 0.261
E50.5 Vitamin A deficiency with night blindness
0.000 0.738 0.261
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.738 0.261
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.738 0.261
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.738 0.261
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.738 0.261
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.738 0.261
E51.9 Thiamine deficiency, unspecified
0.000 0.738 0.261
E51.8 Other manifestations of thiamine deficiency
0.000 0.738 0.261
E51.2 Wernicke's encephalopathy
0.000 0.738 0.261
E51.1 Beriberi
0.000 0.738 0.261
E56.9 Vitamin deficiency, unspecified
0.000 0.738 0.261
E56.8 Deficiency of other vitamins
0.000 0.738 0.261
E56.1 Deficiency of vitamin K
0.000 0.738 0.261
E56.0 Deficiency of vitamin E
0.000 0.738 0.261
E63.9 Nutritional deficiency, unspecified
0.000 0.738 0.261
E63.8 Other specified nutritional deficiencies
0.000 0.738 0.261
E63.1 Imbalance of constituents of food intake
0.000 0.738 0.261
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.738 0.261
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.738 0.261
E64.8 Sequelae of other nutritional deficiencies
0.000 0.738 0.261
E64.3 Sequelae of rickets
0.000 0.738 0.261
E64.2 Sequelae of vitamin C deficiency
0.000 0.738 0.261
E64.1 Sequelae of vitamin A deficiency
0.000 0.738 0.261
E64.0 Sequelae of protein-energy malnutrition
0.000 0.738 0.261
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.000 0.739 0.260
E04.8 Other specified non-toxic goitre
0.000 0.740 0.259
E34.8 Other specified endocrine disorders
0.000 0.742 0.257
E55 Vitamin D deficiency
0.000 0.743 0.257
E53.9 Vitamin B deficiency, unspecified
0.000 0.746 0.254
E87.2 Acidosis
0.000 0.746 0.254
E34.0 Carcinoid syndrome
0.000 0.747 0.253
E83.9 Disorder of mineral metabolism, unspecified
0.000 0.750 0.250
E83.8 Other disorders of mineral metabolism
0.000 0.750 0.250
E83.2 Disorders of zinc metabolism
0.000 0.750 0.250
E83.0 Disorders of copper metabolism
0.000 0.750 0.250
E23.7 Disorder of pituitary gland, unspecified
0.000 0.754 0.246
E23.6 Other disorders of pituitary gland
0.000 0.754 0.246
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.000 0.754 0.246
E23.1 Drug-induced hypopituitarism
0.000 0.754 0.246
E22.1 Hyperprolactinaemia
0.000 0.760 0.239
E87.8 Other disorders of electrolyte and fluid balance, not elsewhere classified
0.000 0.765 0.235
E87.4 Mixed disorder of acid-base balance
0.000 0.767 0.233
E34.9 Endocrine disorder, unspecified
0.000 0.767 0.232
E83.4 Disorders of magnesium metabolism
0.000 0.768 0.232
E85.9 Amyloidosis, unspecified
0.001 0.770 0.230
E87.0 Hyperosmolality and hypernatraemia
0.000 0.770 0.230
E23.2 Diabetes insipidus
0.000 0.777 0.223
E61.9 Deficiency of nutrient element, unspecified
0.000 0.777 0.223
E61.8 Deficiency of other specified nutrient elements
0.000 0.777 0.223
E61.7 Deficiency of multiple nutrient elements
0.000 0.777 0.223
E61.6 Vanadium deficiency
0.000 0.777 0.223
E61.5 Molybdenum deficiency
0.000 0.777 0.223
E61.4 Chromium deficiency
0.000 0.777 0.223
E61.3 Manganese deficiency
0.000 0.777 0.223
E61.0 Copper deficiency
0.000 0.777 0.223
E66.2 Extreme obesity with alveolar hypoventilation
0.000 0.777 0.223
E87.3 Alkalosis
0.000 0.778 0.222
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.781 0.219
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.781 0.219
E16.4 Abnormal secretion of gastrin
0.000 0.781 0.219
E16.3 Increased secretion of glucagon
0.000 0.781 0.219
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.781 0.219
E85.8 Other amyloidosis
0.001 0.782 0.217
E61.1 Iron deficiency
0.000 0.786 0.214
E85.3 Secondary systemic amyloidosis
0.001 0.786 0.213
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.000 0.804 0.196
E87.6 Hypokalaemia
0.000 0.807 0.193
E14.9 Without complications
0.000 0.810 0.190
E04.1 Non-toxic single thyroid nodule
0.000 0.813 0.187
E55.0 Rickets, active
0.000 0.815 0.184
E29.1 Testicular hypofunction
0.001 0.816 0.184
E61.2 Magnesium deficiency
0.001 0.817 0.183
E16.1 Other hypoglycaemia
0.000 0.820 0.180
E13.9 Without complications
0.001 0.821 0.178
E04.2 Non-toxic multinodular goitre
0.000 0.823 0.177
M06.9 Rheumatoid arthritis, unspecified
0.000 0.826 0.174
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.000 0.828 0.172
E21.0 Primary hyperparathyroidism
0.000 0.828 0.172
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)
0.000 0.831 0.169
E89.2 Postprocedural hypoparathyroidism
0.001 0.833 0.165
E16.2 Hypoglycaemia, unspecified
0.000 0.834 0.166
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)
0.000 0.834 0.166
E23.0 Hypopituitarism
0.000 0.835 0.165
E78.9 Disorder of lipoprotein metabolism, unspecified
0.000 0.843 0.157
E83.1 Disorders of iron metabolism
0.000 0.845 0.155
M06.97 Rheumatoid arthritis, unspecified (Ankle and foot)
0.000 0.845 0.155
E87.1 Hypo-osmolality and hyponatraemia
0.000 0.851 0.149
M06.94 Rheumatoid arthritis, unspecified (Hand)
0.000 0.853 0.147
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.000 0.858 0.142
E78.1 Pure hyperglyceridaemia
0.000 0.866 0.134
M06.96 Rheumatoid arthritis, unspecified (Lower leg)
0.000 0.868 0.132
M06.93 Rheumatoid arthritis, unspecified (Forearm)
0.000 0.868 0.132
E07.9 Disorder of thyroid, unspecified
0.001 0.871 0.127
M06.92 Rheumatoid arthritis, unspecified (Upper arm)
0.000 0.873 0.127
M06.98 Rheumatoid arthritis, unspecified (Other)
0.000 0.875 0.125
M06 Other rheumatoid arthritis
0.000 0.876 0.124
E78.3 Hyperchylomicronaemia
0.000 0.876 0.124
E78.4 Other hyperlipidaemia
0.000 0.877 0.123
M06.91 Rheumatoid arthritis, unspecified (Shoulder region)
0.000 0.881 0.118
M06.0 Seronegative rheumatoid arthritis
0.000 0.882 0.118
E78.6 Lipoprotein deficiency
0.000 0.885 0.115
M06.09 Seronegative rheumatoid arthritis (Site unspecified)
0.000 0.889 0.110
E04.9 Non-toxic goitre, unspecified
0.000 0.896 0.104
E87.5 Hyperkalaemia
0.000 0.896 0.104
E78.2 Mixed hyperlipidaemia
0.000 0.898 0.102
G35 Multiple sclerosis
0.000 0.899 0.101
M06.00 Seronegative rheumatoid arthritis (Multiple sites)
0.000 0.902 0.098
E78.8 Other disorders of lipoprotein metabolism
0.000 0.908 0.092
M06.8 Other specified rheumatoid arthritis
0.000 0.911 0.089
M06.2 Rheumatoid bursitis
0.000 0.911 0.089
M06.1 Adult-onset Still's disease
0.000 0.911 0.089
Z88.0 Personal history of allergy to penicillin
0.086 0.914 0.000
M06.3 Rheumatoid nodule
0.000 0.915 0.085
M06.08 Seronegative rheumatoid arthritis (Other)
0.000 0.915 0.085
M06.07 Seronegative rheumatoid arthritis (Ankle and foot)
0.000 0.915 0.085
M06.06 Seronegative rheumatoid arthritis (Lower leg)
0.000 0.915 0.085
M06.05 Seronegative rheumatoid arthritis (Pelvic region and thigh)
0.000 0.915 0.085
M06.04 Seronegative rheumatoid arthritis (Hand)
0.000 0.915 0.085
M06.03 Seronegative rheumatoid arthritis (Forearm)
0.000 0.915 0.085
M06.02 Seronegative rheumatoid arthritis (Upper arm)
0.000 0.915 0.085
M06.01 Seronegative rheumatoid arthritis (Shoulder region)
0.000 0.915 0.085
E11 Non-insulin-dependent diabetes mellitus
0.000 0.920 0.080
E55.9 Vitamin D deficiency, unspecified
0.001 0.923 0.076
M06.4 Inflammatory polyarthropathy
0.000 0.932 0.068
M06.19 Adult-onset Still's disease (Site unspecified)
0.000 0.936 0.064
M06.18 Adult-onset Still's disease (Other)
0.000 0.936 0.064
M06.17 Adult-onset Still's disease (Ankle and foot)
0.000 0.936 0.064
M06.16 Adult-onset Still's disease (Lower leg)
0.000 0.936 0.064
M06.15 Adult-onset Still's disease (Pelvic region and thigh)
0.000 0.936 0.064
M06.14 Adult-onset Still's disease (Hand)
0.000 0.936 0.064
M06.13 Adult-onset Still's disease (Forearm)
0.000 0.936 0.064
M06.12 Adult-onset Still's disease (Upper arm)
0.000 0.936 0.064
M06.11 Adult-onset Still's disease (Shoulder region)
0.000 0.936 0.064
M06.10 Adult-onset Still's disease (Multiple sites)
0.000 0.936 0.064
M06.29 Rheumatoid bursitis (Site unspecified)
0.000 0.936 0.064
M06.28 Rheumatoid bursitis (Other)
0.000 0.936 0.064
M06.27 Rheumatoid bursitis (Ankle and foot)
0.000 0.936 0.064
M06.26 Rheumatoid bursitis (Lower leg)
0.000 0.936 0.064
M06.25 Rheumatoid bursitis (Pelvic region and thigh)
0.000 0.936 0.064
M06.24 Rheumatoid bursitis (Hand)
0.000 0.936 0.064
M06.23 Rheumatoid bursitis (Forearm)
0.000 0.936 0.064
M06.22 Rheumatoid bursitis (Upper arm)
0.000 0.936 0.064
M06.21 Rheumatoid bursitis (Shoulder region)
0.000 0.936 0.064
M06.20 Rheumatoid bursitis (Multiple sites)
0.000 0.936 0.064
M06.89 Other specified rheumatoid arthritis (Site unspecified)
0.000 0.936 0.064
M06.88 Other specified rheumatoid arthritis (Other)
0.000 0.936 0.064
M06.87 Other specified rheumatoid arthritis (Ankle and foot)
0.000 0.936 0.064
M06.86 Other specified rheumatoid arthritis (Lower leg)
0.000 0.936 0.064
M06.85 Other specified rheumatoid arthritis (Pelvic region and thigh)
0.000 0.936 0.064
M06.84 Other specified rheumatoid arthritis (Hand)
0.000 0.936 0.064
M06.83 Other specified rheumatoid arthritis (Forearm)
0.000 0.936 0.064
M06.82 Other specified rheumatoid arthritis (Upper arm)
0.000 0.936 0.064
M06.81 Other specified rheumatoid arthritis (Shoulder region)
0.000 0.936 0.064
M06.80 Other specified rheumatoid arthritis (Multiple sites)
0.000 0.936 0.064
E11.8 With unspecified complications
0.000 0.936 0.064
E83.5 Disorders of calcium metabolism
0.000 0.936 0.064
E11.1 With ketoacidosis
0.000 0.937 0.063
M06.34 Rheumatoid nodule (Hand)
0.000 0.937 0.063
M06.39 Rheumatoid nodule (Site unspecified)
0.000 0.939 0.061
M06.38 Rheumatoid nodule (Other)
0.000 0.939 0.061
M06.36 Rheumatoid nodule (Lower leg)
0.000 0.939 0.061
M06.35 Rheumatoid nodule (Pelvic region and thigh)
0.000 0.939 0.061
M06.33 Rheumatoid nodule (Forearm)
0.000 0.939 0.061
M06.32 Rheumatoid nodule (Upper arm)
0.000 0.939 0.061
M06.31 Rheumatoid nodule (Shoulder region)
0.000 0.939 0.061
M06.30 Rheumatoid nodule (Multiple sites)
0.000 0.939 0.061
E11.7 With multiple complications
0.000 0.942 0.057
E11.0 With coma
0.000 0.943 0.057
E11.3 With ophthalmic complications
0.000 0.943 0.057
M06.37 Rheumatoid nodule (Ankle and foot)
0.000 0.945 0.055
E11.2 With renal complications
0.000 0.946 0.054
M06.40 Inflammatory polyarthropathy (Multiple sites)
0.000 0.951 0.049
M06.48 Inflammatory polyarthropathy (Other)
0.000 0.951 0.049
M06.47 Inflammatory polyarthropathy (Ankle and foot)
0.000 0.951 0.049
M06.46 Inflammatory polyarthropathy (Lower leg)
0.000 0.951 0.049
M06.45 Inflammatory polyarthropathy (Pelvic region and thigh)
0.000 0.951 0.049
M06.44 Inflammatory polyarthropathy (Hand)
0.000 0.951 0.049
M06.43 Inflammatory polyarthropathy (Forearm)
0.000 0.951 0.049
M06.42 Inflammatory polyarthropathy (Upper arm)
0.000 0.951 0.049
M06.41 Inflammatory polyarthropathy (Shoulder region)
0.000 0.951 0.049
G35-G37 Demyelinating diseases of the central nervous system
0.000 0.962 0.038
E11.6 With other specified complications
0.001 0.964 0.035
E11.5 With peripheral circulatory complications
0.000 0.970 0.030
G36 Other acute disseminated demyelination
0.000 0.972 0.028
M06.49 Inflammatory polyarthropathy (Site unspecified)
0.001 0.973 0.026
G37 Other demyelinating diseases of central nervous system
0.000 0.974 0.026
M05-M14 Inflammatory polyarthropathies
0.000 0.976 0.024

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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