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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs2248372
log Bayes Factor = 103.651
Chromosome 6   position 31,446,466  (GRCh37) Explore rs2248372 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E03.9 Hypothyroidism, unspecified
0.000 0.000 1.000
E05.9 Thyrotoxicosis, unspecified
0.000 0.000 1.000
E10.9 Without complications
0.000 0.000 1.000
K90.0 Coeliac disease
0.000 0.000 1.000
L40.9 Psoriasis, unspecified
1.000 0.000 0.000
L40.5 Arthropathic psoriasis
1.000 0.000 0.000
M45.X9 Ankylosing spondylitis (Site unspecified)
1.000 0.000 0.000
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
E00-E07 Disorders of thyroid gland
0.000 0.000 1.000
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.000 1.000
G35 Multiple sclerosis
0.000 0.000 1.000
L40 Psoriasis
1.000 0.000 0.000
E03 Other hypothyroidism
0.000 0.000 1.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.000 1.000
E10-E14 Diabetes mellitus
0.000 0.000 1.000
E10.3 With ophthalmic complications
0.000 0.003 0.997
E20-E35 Disorders of other endocrine glands
0.000 0.008 0.992
E27 Other disorders of adrenal gland
0.000 0.008 0.992
E27.1 Primary adrenocortical insufficiency
0.000 0.009 0.991
T36-T50 Poisoning by drugs, medicaments and biological substances
0.987 0.013 0.000
E10.1 With ketoacidosis
0.000 0.017 0.983
T50 Poisoning by diuretics and other and unspecified drugs, medicaments and biological substances
0.982 0.018 0.000
M07.3 Other psoriatic arthropathies
0.981 0.019 0.000
M45 Ankylosing spondylitis
0.978 0.022 0.000
T50.9 Other and unspecified drugs, medicaments and biological substances
0.978 0.022 0.000
M07.30 Other psoriatic arthropathies (Multiple sites)
0.977 0.023 0.000
T42 Poisoning by antiepileptic, sedative-hypnotic and anti-Parkinsonism drugs
0.976 0.024 0.000
M07.39 Other psoriatic arthropathies (Site unspecified)
0.975 0.025 0.000
M45.X0 Ankylosing spondylitis (Multiple sites in spine)
0.971 0.029 0.000
E06 Thyroiditis
0.000 0.030 0.970
E06.3 Autoimmune thyroiditis
0.000 0.042 0.958
T45 Poisoning by primarily systemic and haematological agents, not elsewhere classified
0.956 0.044 0.000
E10.4 With neurological complications
0.000 0.068 0.932
L40.0 Psoriasis vulgaris
0.930 0.070 0.000
T45.0 Antiallergic and antiemetic drugs
0.926 0.074 0.000
T42.4 Benzodiazepines
0.925 0.075 0.000
M07.36 Other psoriatic arthropathies (Lower leg)
0.919 0.081 0.000
T38 Poisoning by hormones and their synthetic substitutes and antagonists, not elsewhere classified
0.906 0.094 0.000
T42.6 Other antiepileptic and sedative-hypnotic drugs
0.903 0.097 0.000
E10.0 With coma
0.000 0.104 0.896
T43 Poisoning by psychotropic drugs, not elsewhere classified
0.890 0.110 0.000
M07.37 Other psoriatic arthropathies (Ankle and foot)
0.885 0.115 0.000
T44 Poisoning by drugs primarily affecting the autonomic nervous system
0.881 0.119 0.000
M07.34 Other psoriatic arthropathies (Hand)
0.879 0.121 0.000
E20 Hypoparathyroidism
0.000 0.136 0.863
T45.1 Antineoplastic and immunosuppressive drugs
0.858 0.142 0.000
E27.2 Addisonian crisis
0.000 0.149 0.851
E10.2 With renal complications
0.000 0.150 0.850
T39 Poisoning by nonopioid analgesics, antipyretics and antirheumatics
0.849 0.151 0.000
T46 Poisoning by agents primarily affecting the cardiovascular system
0.842 0.158 0.000
T42.7 Antiepileptic and sedative-hypnotic drugs, unspecified
0.838 0.162 0.000
E14 Unspecified diabetes mellitus
0.000 0.171 0.829
T50.2 Carbonic-anhydrase inhibitors, benzothiadiazides and other diuretics
0.827 0.173 0.000
T43.5 Other and unspecified antipsychotics and neuroleptics
0.826 0.174 0.000
T39.1 4-Aminophenol derivatives
0.817 0.183 0.000
L40.1 Generalised pustular psoriasis
0.804 0.196 0.000
M07.38 Other psoriatic arthropathies (Other)
0.802 0.198 0.000
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.219 0.781
E27.9 Disorder of adrenal gland, unspecified
0.000 0.222 0.778
T47 Poisoning by agents primarily affecting gastro-intestinal system
0.778 0.222 0.000
T38.1 Thyroid hormones and substitutes
0.773 0.227 0.000
E20.9 Hypoparathyroidism, unspecified
0.000 0.229 0.771
E25 Adrenogenital disorders
0.000 0.229 0.771
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.000 0.230 0.770
M07.35 Other psoriatic arthropathies (Pelvic region and thigh)
0.769 0.231 0.000
T43.6 Psychostimulants with abuse potential
0.768 0.232 0.000
T44.3 Other parasympatholytics [anticholinergics and antimuscarines] and spasmolytics, not elsewhere classified
0.767 0.233 0.000
K90 Intestinal malabsorption
0.000 0.236 0.764
M07.31 Other psoriatic arthropathies (Shoulder region)
0.762 0.238 0.000
T38.8 Other and unspecified hormones and their synthetic substitutes
0.754 0.246 0.000
E50-E64 Other nutritional deficiencies
0.000 0.250 0.750
L40.4 Guttate psoriasis
0.750 0.250 0.000
M45.X6 Ankylosing spondylitis (Lumbar region)
0.749 0.250 0.000
E14.3 With ophthalmic complications
0.000 0.253 0.747
L40.8 Other psoriasis
0.741 0.259 0.000
M45.X2 Ankylosing spondylitis (Cervical region)
0.735 0.265 0.000
T37 Poisoning by other systemic anti-infectives and antiparasitics
0.732 0.268 0.000
E65-E68 Obesity and other hyperalimentation
0.000 0.272 0.728
T38.3 Insulin and oral hypoglycaemic [antidiabetic] drugs
0.719 0.281 0.000
E10.5 With peripheral circulatory complications
0.000 0.283 0.717
E05.5 Thyroid crisis or storm
0.000 0.283 0.717
E05.4 Thyrotoxicosis factitia
0.000 0.283 0.717
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.283 0.717
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.283 0.717
E10.7 With multiple complications
0.000 0.283 0.717
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.283 0.717
E00 Congenital iodine-deficiency syndrome
0.000 0.283 0.717
L40.2 Acrodermatitis continua
0.717 0.283 0.000
E03.5 Myxoedema coma
0.000 0.283 0.717
E03.4 Atrophy of thyroid (acquired)
0.000 0.283 0.717
E03.3 Postinfectious hypothyroidism
0.000 0.283 0.717
E12 Malnutrition-related diabetes mellitus
0.000 0.283 0.717
E23 Hypofunction and other disorders of pituitary gland
0.000 0.285 0.715
T46.2 Other antidysrhythmic drugs, not elsewhere classified
0.713 0.287 0.000
E03.8 Other specified hypothyroidism
0.000 0.287 0.713
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.289 0.711
E32 Diseases of thymus
0.000 0.289 0.711
E31 Polyglandular dysfunction
0.000 0.289 0.711
E30 Disorders of puberty, not elsewhere classified
0.000 0.289 0.711
E27.5 Adrenomedullary hyperfunction
0.000 0.289 0.711
E27.0 Other adrenocortical overactivity
0.000 0.289 0.711
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.290 0.710
E07 Other disorders of thyroid
0.000 0.291 0.709
T42.0 Hydantoin derivatives
0.709 0.291 0.000
T49 Poisoning by topical agents primarily affecting skin and mucous membrane and by ophthalmological, otorhinolarygological and dental drugs
0.708 0.292 0.000
T48 Poisoning by agents primarily acting on smooth and skeletal muscles and the respiratory system
0.708 0.292 0.000
T41 Poisoning by anaesthetics and therapeutic gases
0.708 0.292 0.000
E27.4 Other and unspecified adrenocortical insufficiency
0.000 0.293 0.707
E21.3 Hyperparathyroidism, unspecified
0.000 0.294 0.706
T50.7 Analeptics and opioid receptor antagonists
0.704 0.296 0.000
T50.6 Antidotes and chelating agents, not elsewhere classified
0.704 0.296 0.000
T50.5 Appetite depressants
0.704 0.296 0.000
T50.3 Electrolytic, caloric and water-balance agents
0.704 0.296 0.000
T50.1 Loop [high-ceiling] diuretics
0.704 0.296 0.000
T50.0 Mineralocorticoids and their antagonists
0.704 0.296 0.000
M07.33 Other psoriatic arthropathies (Forearm)
0.704 0.296 0.000
M07.32 Other psoriatic arthropathies (Upper arm)
0.704 0.296 0.000
M45.X8 Ankylosing spondylitis (Sacral and sacrococcygeal region)
0.701 0.299 0.000
M45.X7 Ankylosing spondylitis (Lumbosacral region)
0.701 0.299 0.000
M45.X5 Ankylosing spondylitis (Thoracolumbar region)
0.701 0.299 0.000
M45.X4 Ankylosing spondylitis (Thoracic region)
0.701 0.299 0.000
M45.X3 Ankylosing spondylitis (Cervicothoracic region)
0.701 0.299 0.000
M45.X1 Ankylosing spondylitis (Occipito-atlanto-axial region)
0.701 0.299 0.000
T42.5 Mixed antiepileptics, not elsewhere classified
0.700 0.300 0.000
T42.3 Barbiturates
0.700 0.300 0.000
T42.2 Succinimides and oxazolidinediones
0.700 0.300 0.000
E10.8 With unspecified complications
0.000 0.302 0.698
E06.4 Drug-induced thyroiditis
0.000 0.304 0.696
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.304 0.696
E06.0 Acute thyroiditis
0.000 0.304 0.696
K90.9 Intestinal malabsorption, unspecified
0.000 0.306 0.694
T44.7 Beta-Adrenoreceeptor antagonists, not elsewhere classified
0.694 0.306 0.000
E53 Deficiency of other B group vitamins
0.000 0.307 0.693
T43.1 Monoamine-oxidase-inhibitor antidepressants
0.690 0.310 0.000
T45.9 Primarily systemic and haematological agent, unspecified
0.685 0.315 0.000
T45.8 Other primarily systemic and haematological agents
0.685 0.315 0.000
T45.7 Anticoagulant antagonists, vitamin K and other coagulants
0.685 0.315 0.000
T45.6 Fibrinolysis-affecting drugs
0.685 0.315 0.000
T45.4 Iron and its compounds
0.685 0.315 0.000
T45.3 Enzymes, not elsewhere classified
0.685 0.315 0.000
L40.3 Pustulosis palmaris et plantaris
0.684 0.316 0.000
T43.3 Phenothiazine antipsychotics and neuroleptics
0.682 0.318 0.000
T42.8 Anti-Parkinsonism drugs and other central muscle-tone depressants
0.675 0.325 0.000
E06.9 Thyroiditis, unspecified
0.000 0.335 0.665
E65 Localised adiposity
0.000 0.337 0.663
T44.9 Other and unspecified drugs primarily affecting the nervous system
0.663 0.337 0.000
E14.6 With other specified complications
0.000 0.338 0.662
T50.8 Diagnostic agents
0.660 0.340 0.000
T46.1 Calcium-channel blockers
0.659 0.341 0.000
T42.1 Iminostilbenes
0.658 0.342 0.000
E10.6 With other specified complications
0.000 0.345 0.655
T46.6 Antihyperlipidaemic and antiarteriosclerotic drugs
0.654 0.346 0.000
E27.3 Drug-induced adrenocortical insufficiency
0.000 0.349 0.651
T38.9 Other and unspecified hormone antagonists
0.650 0.350 0.000
T38.7 Androgens and anabolic congeners
0.650 0.350 0.000
T38.6 Antigonadotrophins. antioestrogens, antiandrogens, not elsewhere classified
0.650 0.350 0.000
T38.5 Other oestrogens and progestogens
0.650 0.350 0.000
T38.4 Oral contraceptives
0.650 0.350 0.000
T38.2 Antithyroid drugs
0.650 0.350 0.000
T38.0 Glucocorticoids and synthetic analogues
0.650 0.350 0.000
T45.2 Vitamins, not elsewhere classified
0.650 0.350 0.000
E53.8 Deficiency of other specified B group vitamins
0.000 0.354 0.646
E27.8 Other specified disorders of adrenal gland
0.000 0.356 0.644
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.359 0.641
T43.9 Psychotropic drug, unspecified
0.638 0.362 0.000
T43.8 Other psychotropic drugs, not elsewhere classified
0.638 0.362 0.000
E06.1 Subacute thyroiditis
0.000 0.366 0.633
T44.8 Centrally acting and afrenergic-neuron-blocking agents, not elsewhere classified
0.632 0.368 0.000
T44.6 Alpha-Adrenoreceeptor antagonists, not elsewhere classified
0.632 0.368 0.000
T44.5 Predominantly Beta-adrenoreceptor agonists, not elsewhere classified
0.632 0.368 0.000
T44.4 Predominantly Alpha-adrenoreceptor agonists, not elsewhere classified
0.632 0.368 0.000
T44.2 Ganglionic blocking drugs, not elsewhere classified
0.632 0.368 0.000
T44.1 Other parasympathomimetics [cholinergics]
0.632 0.368 0.000
T44.0 Anticholinesterase agents
0.632 0.368 0.000
E05.8 Other thyrotoxicosis
0.000 0.371 0.629
T43.4 Butyrophenone and thioxanthene neuroleptics
0.627 0.373 0.000
E06.5 Other chronic thyroiditis
0.000 0.375 0.625
E40-E46 Malnutrition
0.000 0.376 0.624
E14.1 With ketoacidosis
0.000 0.378 0.622
T50.4 Drugs affecting uric acid metabolism
0.621 0.379 0.000
T39.9 Nonopioid analgesic, antipyretic and antirheumatic, unspecified
0.620 0.380 0.000
E20.8 Other hypoparathyroidism
0.000 0.381 0.619
E20.1 Pseudohypoparathyroidism
0.000 0.381 0.619
E20.0 Idiopathic hypoparathyroidism
0.000 0.381 0.619
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.383 0.617
E03.1 Congenital hypothyroidism without goitre
0.000 0.383 0.616
E14.8 With unspecified complications
0.000 0.383 0.617
T43.2 Other and unspecified antidepressants
0.614 0.386 0.000
T46.4 Angiotensin-converting-enzyme inhibitors
0.614 0.386 0.000
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.000 0.388 0.612
T39.4 Antirheumatics, not elsewhere classified
0.608 0.391 0.000
T39.2 Pyrazolone derivatives
0.608 0.391 0.000
E14.5 With peripheral circulatory complications
0.000 0.392 0.608
E26 Hyperaldosteronism
0.000 0.395 0.605
T46.9 Other and unspecified agents primarily affecting the cardiovascular system
0.603 0.396 0.000
T46.8 Antivaricose drugs, including sclerosing agents
0.603 0.396 0.000
T46.7 Peripheral vasodilators
0.603 0.396 0.000
T46.0 Cardiac-stimulant glycosides and drugs of similar action
0.603 0.396 0.000
T47.1 Other antacids and anti-gastric-secretion drugs
0.601 0.399 0.000
E14.2 Withrenal complications
0.000 0.400 0.600
E28 Ovarian dysfunction
0.000 0.401 0.599
T47.6 Antidiarrhoeal drugs
0.596 0.404 0.000
E14.7 With multiple complications
0.000 0.406 0.594
E14.0 With coma
0.000 0.406 0.594
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.000 0.411 0.589
E23.2 Diabetes insipidus
0.000 0.412 0.588
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.000 0.417 0.583
T36 Poisoning by systemic antibiotics
0.582 0.418 0.000
E23.6 Other disorders of pituitary gland
0.000 0.422 0.578
T46.5 Other antihypertensive drugs, not elsewhere classified
0.568 0.432 0.000
T47.4 Other laxatives
0.567 0.433 0.000
K90.8 Other intestinal malabsorption
0.000 0.434 0.566
E23.7 Disorder of pituitary gland, unspecified
0.000 0.435 0.565
E07.9 Disorder of thyroid, unspecified
0.000 0.436 0.564
T39.0 Salicylates
0.564 0.436 0.000
T47.9 Agent primarily affecting the gastro-intestinal system, unspecified
0.558 0.442 0.000
T47.8 Other agents primarily affecting the gastro-intestinal system
0.558 0.442 0.000
T47.7 Emetics
0.558 0.442 0.000
T47.5 Digestants
0.558 0.442 0.000
T47.3 Saline and osmotic laxatives
0.558 0.442 0.000
T47.0 Histamine H(2)-receptor antagonists
0.558 0.442 0.000
G35-G37 Demyelinating diseases of the central nervous system
0.000 0.446 0.554
E25.9 Adrenogenital disorder, unspecified
0.000 0.447 0.553
E25.8 Other adrenogenital disorders
0.000 0.447 0.553
E21.2 Other hyperparathyroidism
0.000 0.448 0.552
T46.3 Coronary vasodilators, not elsewhere classified
0.552 0.448 0.000
E21.4 Other specified disorders of parathyroid gland
0.000 0.450 0.550
T37.8 Other specified systemic anti-infectives and antiparasitics
0.549 0.451 0.000
K90.3 Pancreatic steatorrhoea
0.000 0.452 0.548
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.452 0.548
K90.1 Tropical sprue
0.000 0.452 0.548
T47.2 Stimulant laxatives
0.545 0.455 0.000
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.462 0.538
E63 Other nutritional deficiencies
0.000 0.462 0.538
E51 Thiamine deficiency
0.000 0.462 0.538
E50 Vitamin A deficiency
0.000 0.462 0.538
E60 Dietary zinc deficiency
0.000 0.462 0.538
E59 Dietary selenium deficiency
0.000 0.462 0.538
E54 Ascorbic acid deficiency
0.000 0.462 0.538
E52 Niacin deficiency [pellagra]
0.000 0.462 0.538
E24 Cushing's syndrome
0.000 0.462 0.538
E34 Other endocrine disorders
0.000 0.463 0.537
T37.9 Systemic anti-infective and antiparasitic, unspecified
0.525 0.475 0.000
T37.5 Antiviral drugs
0.525 0.475 0.000
T37.4 Anthelminthics
0.525 0.475 0.000
T37.3 Other antiprotozoal drugs
0.525 0.475 0.000
T37.2 Antimalarials and drugs acting on other blood protozoa
0.525 0.475 0.000
T37.1 Antimycobacterial drugs
0.525 0.475 0.000
T37.0 Sulphonamides
0.525 0.475 0.000
E67 Other hyperalimentation
0.000 0.478 0.522
E68 Sequelae of hyperalimentation
0.000 0.478 0.522
E21.5 Disorder of parathyroid gland, unspecified
0.000 0.479 0.521
E53.9 Vitamin B deficiency, unspecified
0.000 0.480 0.520
E56 Other vitamin deficiencies
0.000 0.484 0.516
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.000 0.486 0.514
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.000 0.486 0.514
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.000 0.486 0.514
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.000 0.486 0.514
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.486 0.514
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.000 0.486 0.514
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.000 0.486 0.514
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.000 0.486 0.514
E12.9 Without complications
0.000 0.486 0.514
E12.8 With unspecified complications
0.000 0.486 0.514
E12.7 With multiple complications
0.000 0.486 0.514
E12.6 With other specified complications
0.000 0.486 0.514
E12.5 With peripheral circulatory complications
0.000 0.486 0.514
E12.4 With neurological complications
0.000 0.486 0.514
E12.3 With ophthalmic complications
0.000 0.486 0.514
E12.2 With renal complications
0.000 0.486 0.514
E12.1 With ketoacidosis
0.000 0.486 0.514
E12.0 With coma
0.000 0.486 0.514
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.000 0.487 0.513
E23.1 Drug-induced hypopituitarism
0.000 0.487 0.513
T39.8 Other nonopioid analgesics and antipyretics, not elsewhere classified
0.512 0.487 0.000
E30.9 Disorder of puberty, unspecified
0.000 0.490 0.510
E30.8 Other disorders of puberty
0.000 0.490 0.510
E30.1 Precocious puberty
0.000 0.490 0.510
E30.0 Delayed puberty
0.000 0.490 0.510
E31.9 Polyglandular dysfunction, unspecified
0.000 0.490 0.510
E31.8 Other polyglandular dysfunction
0.000 0.490 0.510
E31.1 Polyglandular hyperfunction
0.000 0.490 0.510
E31.0 Autoimmune polyglandular failure
0.000 0.490 0.510
E32.9 Disease of thymus, unspecified
0.000 0.490 0.510
E32.8 Other diseases of thymus
0.000 0.490 0.510
E32.1 Abscess of thymus
0.000 0.490 0.510
E32.0 Persistent hyperplasia of thymus
0.000 0.490 0.510
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.490 0.510
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.490 0.510
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.490 0.510
E07.1 Dyshormogenetic goitre
0.000 0.491 0.509
E07.0 Hypersecretion of calcitonin
0.000 0.491 0.509
T41.5 Therapeutic gases
0.507 0.492 0.000
T41.4 Anaesthetic, unspecified
0.507 0.492 0.000
T41.3 Local anaesthetics
0.507 0.492 0.000
T41.2 Other and unspecified general anaesthetics
0.507 0.492 0.000
T41.1 Intravenous anaesthetics
0.507 0.492 0.000
T41.0 Inhaled anaesthetics
0.507 0.492 0.000
T48.7 Other and unspecified agents primarily acting on the respiratory system
0.507 0.492 0.000
T48.6 Antiasthmatics, not elsewhere classified
0.507 0.492 0.000
T48.5 Anti-common-cold drugs
0.507 0.492 0.000
T48.4 Expectorants
0.507 0.492 0.000
T48.3 Antitussives
0.507 0.492 0.000
T48.2 Other and unspecified agents primarily acting on muscles
0.507 0.492 0.000
T48.1 Skeletal muscle relaxants [neuromuscular blocking agents]
0.507 0.492 0.000
T48.0 Oxytocic drugs
0.507 0.492 0.000
T49.9 Topical agent, unspecified
0.507 0.492 0.000
T49.8 Other topical agents
0.507 0.492 0.000
T49.7 Dental drugs, topically applied
0.507 0.492 0.000
T49.6 Otorhinolaryngological drugs and preparations
0.507 0.492 0.000
T49.5 Ophthalmological drugs and preparations
0.507 0.492 0.000
T49.4 Keratolytics, keratoplastics and other hair treatment drugs and preparations
0.507 0.492 0.000
T49.3 Emollients, demulcents and protectants
0.507 0.492 0.000
T49.2 Local astringents and local detergents
0.507 0.492 0.000
T49.1 Antipruritics
0.507 0.492 0.000
T49.0 Local antifungal, anti-infective and anti-inflammatory drugs, not elsewhere classified
0.507 0.492 0.000
E53.1 Pyridoxine deficiency
0.000 0.503 0.497
E53.0 Riboflavin deficiency
0.000 0.503 0.497
E55 Vitamin D deficiency
0.000 0.505 0.495
E29 Testicular dysfunction
0.001 0.507 0.493
E13 Other specified diabetes mellitus
0.001 0.522 0.477
E28.3 Primary ovarian failure
0.000 0.531 0.469
E58 Dietary calcium deficiency
0.000 0.534 0.465
E14.4 With neurological complications
0.000 0.536 0.463
G37 Other demyelinating diseases of central nervous system
0.000 0.539 0.461
T45.5 Anticoagulants
0.456 0.544 0.001
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.544 0.455
M07 Psoriatic and enteropathic arthropathies
0.453 0.547 0.000
E22 Hyperfunction of pituitary gland
0.000 0.548 0.451
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.552 0.448
E45 Retarded development following protein-energy malnutrition
0.000 0.552 0.448
E43 Unspecified severe protein-energy malnutrition
0.000 0.552 0.448
E42 Marasmic kwashiorkor
0.000 0.552 0.448
E41 Nutritional marasmus
0.000 0.552 0.448
E40 Kwashiorkor
0.000 0.552 0.448
E15 Nondiabetic hypoglycaemic coma
0.000 0.557 0.442
E26.8 Other hyperaldosteronism
0.000 0.566 0.434
E26.1 Secondary hyperaldosteronism
0.000 0.566 0.434
E28.9 Ovarian dysfunction, unspecified
0.000 0.570 0.430
E28.8 Other ovarian dysfunction
0.000 0.570 0.430
E28.1 Androgen excess
0.000 0.570 0.430
E28.0 Oestrogen excess
0.000 0.570 0.430
E07.8 Other specified disorders of thyroid
0.000 0.578 0.421
T36.4 Tetracyclines
0.420 0.580 0.000
E26.9 Hyperaldosteronism, unspecified
0.000 0.582 0.418
T36.9 Systemic antibiotic, unspecified
0.417 0.582 0.000
T36.8 Other systemic antibiotics
0.417 0.582 0.000
T36.7 Antifungal antibiotics, systemically used
0.417 0.582 0.000
T36.6 Rifamycins
0.417 0.582 0.000
T36.5 Aminoglycosides
0.417 0.582 0.000
T36.3 Macrolides
0.417 0.582 0.000
T36.2 Chloramphenicol group
0.417 0.582 0.000
T36.1 Cefalosporins and other Beta-lactam antibiotics
0.417 0.582 0.000
G36 Other acute disseminated demyelination
0.000 0.600 0.400
E24.2 Drug-induced Cushing's syndrome
0.000 0.607 0.393
E14.9 Without complications
0.000 0.607 0.393
E24.8 Other Cushing's syndrome
0.000 0.614 0.385
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.000 0.614 0.385
E24.3 Ectopic ACTH syndrome
0.000 0.614 0.385
E24.1 Nelson's syndrome
0.000 0.614 0.385
E50.9 Vitamin A deficiency, unspecified
0.000 0.614 0.386
E50.8 Other manifestations of vitamin A deficiency
0.000 0.614 0.386
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.614 0.386
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.614 0.386
E50.5 Vitamin A deficiency with night blindness
0.000 0.614 0.386
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.614 0.386
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.614 0.386
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.614 0.386
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.614 0.386
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.614 0.386
E51.9 Thiamine deficiency, unspecified
0.000 0.614 0.386
E51.8 Other manifestations of thiamine deficiency
0.000 0.614 0.386
E51.2 Wernicke's encephalopathy
0.000 0.614 0.386
E51.1 Beriberi
0.000 0.614 0.386
E63.9 Nutritional deficiency, unspecified
0.000 0.614 0.386
E63.8 Other specified nutritional deficiencies
0.000 0.614 0.386
E63.1 Imbalance of constituents of food intake
0.000 0.614 0.386
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.614 0.386
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.614 0.386
E64.8 Sequelae of other nutritional deficiencies
0.000 0.614 0.386
E64.3 Sequelae of rickets
0.000 0.614 0.386
E64.2 Sequelae of vitamin C deficiency
0.000 0.614 0.386
E64.1 Sequelae of vitamin A deficiency
0.000 0.614 0.386
E64.0 Sequelae of protein-energy malnutrition
0.000 0.614 0.386
E34.5 Androgen resistance syndrome
0.000 0.615 0.385
E34.4 Constitutional tall stature
0.000 0.615 0.385
E34.2 Ectopic hormone secretion, not elsewhere classified
0.000 0.615 0.385
E34.1 Other hypersecretion of intestinal hormones
0.000 0.615 0.385
E34.0 Carcinoid syndrome
0.000 0.622 0.378
G37.8 Other specified demyelinating diseases of central nervous system
0.000 0.622 0.378
E61 Deficiency of other nutrient elements
0.000 0.623 0.377
T39.3 Other nonsteroidal anti-inflammatory drugs [NSAID]
0.375 0.625 0.000
E67.8 Other specified hyperalimentation
0.000 0.625 0.374
E67.3 Hypervitaminosis D
0.000 0.625 0.374
E67.2 Megavitamin-B6 syndrome
0.000 0.625 0.374
E67.1 Hypercarotenaemia
0.000 0.625 0.374
E67.0 Hypervitaminosis A
0.000 0.625 0.374
E34.3 Short stature, not elsewhere classified
0.000 0.627 0.373
T40 Poisoning by narcotics and psychodysleptics [hallucinogens]
0.371 0.629 0.000
E56.9 Vitamin deficiency, unspecified
0.000 0.630 0.370
E56.8 Deficiency of other vitamins
0.000 0.630 0.370
E56.0 Deficiency of vitamin E
0.000 0.630 0.370
E70-E90 Metabolic disorders
0.000 0.638 0.362
E46 Unspecified protein-energy malnutrition
0.000 0.645 0.355
E55.0 Rickets, active
0.000 0.645 0.355
E29.9 Testicular dysfunction, unspecified
0.001 0.646 0.353
E29.8 Other testicular dysfunction
0.001 0.646 0.353
E29.0 Testicular hyperfunction
0.001 0.646 0.353
E26.0 Primary hyperaldosteronism
0.000 0.648 0.351
E22.0 Acromegaly and pituitary gigantism
0.000 0.649 0.351
E56.1 Deficiency of vitamin K
0.000 0.651 0.348
G37.9 Demyelinating disease of central nervous system, unspecified
0.000 0.652 0.348
E34.9 Endocrine disorder, unspecified
0.000 0.652 0.347
E73 Lactose intolerance
0.000 0.653 0.347
E13.3 With ophthalmic complications
0.001 0.656 0.343
E13.8 With unspecified complications
0.001 0.657 0.342
E13.7 With multiple complications
0.001 0.657 0.342
E13.6 With other specified complications
0.001 0.657 0.342
E13.5 With peripheral circulatory complications
0.001 0.657 0.342
E13.4 With neurological complications
0.001 0.657 0.342
E13.2 With renal complications
0.001 0.657 0.342
E13.1 With ketoacidosis
0.001 0.657 0.342
E13.0 With coma
0.001 0.657 0.342
E16 Other disorders of pancreatic internal secretion
0.000 0.657 0.343
G37.3 Acute transverse myelitis in demyelinating disease of central nervous system
0.000 0.660 0.340
E73.9 Lactose intolerance, unspecified
0.000 0.663 0.337
G37.5 Concentric sclerosis [Balo]
0.000 0.669 0.331
G37.4 Subacute necrotising myelitis
0.000 0.669 0.331
G37.2 Central pontine myelinolysis
0.000 0.669 0.331
G37.1 Central demyelination of corpus callosum
0.000 0.669 0.331
G37.0 Diffuse sclerosis
0.000 0.669 0.331
M07.6 Other enteropathic arthropathies
0.325 0.675 0.000
M07.5 Arthropathy in ulcerative colitis
0.325 0.675 0.000
M07.4 Arthropathy in Crohn's disease [regional enteritis]
0.325 0.675 0.000
M07.2 Psoriatic spondylitis
0.325 0.675 0.000
M07.1 Arthritis mutilans
0.325 0.675 0.000
M07.0 Distal interphalangeal psoriatic arthropathy
0.325 0.675 0.000
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.676 0.324
E22.8 Other hyperfunction of pituitary gland
0.000 0.676 0.324
E44.1 Mild protein-energy malnutrition
0.000 0.679 0.321
E44.0 Moderate protein-energy malnutrition
0.000 0.679 0.321
E88 Other metabolic disorders
0.000 0.684 0.316
E55.9 Vitamin D deficiency, unspecified
0.000 0.688 0.312
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.000 0.689 0.311
E24.0 Pituitary-dependent Cushing's disease
0.000 0.689 0.310
E24.9 Cushing's syndrome, unspecified
0.000 0.691 0.308
E34.8 Other specified endocrine disorders
0.000 0.696 0.304
E89.0 Postprocedural hypothyroidism
0.000 0.705 0.295
L40-L45 Papulosquamous disorders
0.292 0.708 0.000
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.708 0.292
G36.0 Neuromyelitis optica [Devic]
0.000 0.710 0.290
G36.9 Acute disseminated demyelination, unspecified
0.000 0.713 0.287
G36.8 Other specified acute disseminated demyelination
0.000 0.713 0.287
G36.1 Acute and subacute haemorrhagic leukoencephalitis [Hurst]
0.000 0.713 0.287
T36.0 Penicillins
0.286 0.713 0.001
T40.1 Heroin
0.278 0.722 0.000
E84 Cystic fibrosis
0.000 0.722 0.278
R41.3 Other amnesia
0.000 0.723 0.277
E61.9 Deficiency of nutrient element, unspecified
0.000 0.729 0.270
E61.8 Deficiency of other specified nutrient elements
0.000 0.729 0.270
E61.7 Deficiency of multiple nutrient elements
0.000 0.729 0.270
E61.6 Vanadium deficiency
0.000 0.729 0.270
E61.5 Molybdenum deficiency
0.000 0.729 0.270
E61.4 Chromium deficiency
0.000 0.729 0.270
E61.3 Manganese deficiency
0.000 0.729 0.270
E61.0 Copper deficiency
0.000 0.729 0.270
R41.0 Disorientation, unspecified
0.000 0.730 0.270
E88.0 Disorders of plasma-protein metabolism, not elsewhere classified
0.000 0.730 0.270
E79 Disorders of purine and pyrimidine metabolism
0.000 0.732 0.268
T40.5 Cocaine
0.268 0.732 0.000
R41 Other symptoms and signs involving cognitive functions and awareness
0.000 0.732 0.268
T40.9 Other and unspecified psychodysleptics [hallucinogens]
0.266 0.734 0.000
T40.8 Lysergide [LSD]
0.266 0.734 0.000
T40.7 Cannabis (derivatives)
0.266 0.734 0.000
T40.3 Methadone
0.266 0.734 0.000
T40.0 Opium
0.266 0.734 0.000
E70 Disorders of aromatic amino-acid metabolism
0.000 0.738 0.262
E77 Disorders of glycoprotein metabolism
0.000 0.740 0.260
E76 Disorders of glycosaminoglycan metabolism
0.000 0.740 0.260
E72 Other disorders of amino-acid metabolism
0.000 0.740 0.260
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.000 0.740 0.260
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.000 0.740 0.260
E73.8 Other lactose intolerance
0.000 0.751 0.249
E73.1 Secondary lactase deficiency
0.000 0.751 0.249
E73.0 Congenital lactase deficiency
0.000 0.751 0.249
E61.2 Magnesium deficiency
0.000 0.752 0.248
E22.1 Hyperprolactinaemia
0.000 0.752 0.248
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.754 0.246
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.754 0.246
E16.4 Abnormal secretion of gastrin
0.000 0.754 0.246
E16.3 Increased secretion of glucagon
0.000 0.754 0.246
T40.2 Other opioids
0.241 0.759 0.000
E88.2 Lipomatosis, not elsewhere classified
0.000 0.759 0.241
E88.9 Metabolic disorder, unspecified
0.000 0.762 0.238
E88.8 Other specified metabolic disorders
0.000 0.763 0.236
C82.9 Follicular non-Hodgkin's lymphoma, unspecified
0.234 0.766 0.000
E28.2 Polycystic ovarian syndrome
0.000 0.767 0.233
M07.09 Distal interphalangeal psoriatic arthropathy (Site unspecified)
0.233 0.767 0.000
M07.08 Distal interphalangeal proriatic arthropathy-Other
0.233 0.767 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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