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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs2253907
log Bayes Factor = 110.95
Chromosome 6   position 31,336,870  (GRCh37) Explore rs2253907 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E10.9 Without complications
0.000 0.000 1.000
E10.3 With ophthalmic complications
0.000 0.000 1.000
K90.0 Coeliac disease
0.000 0.000 1.000
M45.X9 Ankylosing spondylitis (Site unspecified)
1.000 0.000 0.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
E10-E14 Diabetes mellitus
0.000 0.000 1.000
E00-E07 Disorders of thyroid gland
0.000 0.000 1.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.000 1.000
E14.9 Without complications
0.000 0.000 1.000
M06.9 Rheumatoid arthritis, unspecified
0.000 0.000 1.000
E14 Unspecified diabetes mellitus
0.000 0.000 1.000
E11 Non-insulin-dependent diabetes mellitus
0.000 0.000 1.000
E03.9 Hypothyroidism, unspecified
0.000 0.000 1.000
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.000 1.000
E03 Other hypothyroidism
0.000 0.000 1.000
E10.1 With ketoacidosis
0.000 0.000 1.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.000 1.000
E16 Other disorders of pancreatic internal secretion
0.000 0.000 1.000
E16.2 Hypoglycaemia, unspecified
0.000 0.000 1.000
E20-E35 Disorders of other endocrine glands
0.000 0.001 0.999
E05.9 Thyrotoxicosis, unspecified
0.000 0.001 0.999
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)
0.000 0.001 0.999
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)
0.000 0.001 0.999
E27 Other disorders of adrenal gland
0.000 0.002 0.998
E11.9 Without complications
0.000 0.002 0.998
E83.1 Disorders of iron metabolism
0.997 0.003 0.000
E27.1 Primary adrenocortical insufficiency
0.000 0.005 0.995
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.007 0.993
E10.4 With neurological complications
0.000 0.008 0.992
K51.9 Ulcerative colitis, unspecified
0.985 0.015 0.000
K51 Ulcerative colitis
0.985 0.015 0.000
E11.3 With ophthalmic complications
0.000 0.017 0.983
M45 Ankylosing spondylitis
0.982 0.018 0.000
M45.X0 Ankylosing spondylitis (Multiple sites in spine)
0.978 0.022 0.000
J45.9 Asthma, unspecified
0.000 0.029 0.971
M06.94 Rheumatoid arthritis, unspecified (Hand)
0.000 0.045 0.955
M06.91 Rheumatoid arthritis, unspecified (Shoulder region)
0.000 0.045 0.955
K51.2 Ulcerative (chronic) proctitis
0.952 0.048 0.000
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.000 0.051 0.949
K51.3 Ulcerative (chronic) rectosigmoiditis
0.949 0.051 0.000
E11.1 With ketoacidosis
0.000 0.052 0.948
M06.96 Rheumatoid arthritis, unspecified (Lower leg)
0.000 0.054 0.946
E10.0 With coma
0.000 0.056 0.944
K51.4 Pseudopolyposis of colon
0.933 0.067 0.000
E14.3 With ophthalmic complications
0.000 0.089 0.911
E27.4 Other and unspecified adrenocortical insufficiency
0.000 0.089 0.911
E10.8 With unspecified complications
0.000 0.096 0.904
E23 Hypofunction and other disorders of pituitary gland
0.000 0.096 0.904
M06.92 Rheumatoid arthritis, unspecified (Upper arm)
0.000 0.101 0.899
E10.2 With renal complications
0.000 0.106 0.894
E11.5 With peripheral circulatory complications
0.000 0.112 0.888
E27.9 Disorder of adrenal gland, unspecified
0.000 0.134 0.866
E11.0 With coma
0.000 0.134 0.866
K51.5 Mucosal proctocolitis
0.858 0.142 0.000
E22 Hyperfunction of pituitary gland
0.000 0.145 0.855
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.153 0.847
E14.1 With ketoacidosis
0.000 0.154 0.846
E10.5 With peripheral circulatory complications
0.000 0.163 0.837
E07 Other disorders of thyroid
0.000 0.179 0.821
E10.6 With other specified complications
0.000 0.184 0.816
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.189 0.811
E14.6 With other specified complications
0.000 0.193 0.807
E23.2 Diabetes insipidus
0.000 0.195 0.805
E23.7 Disorder of pituitary gland, unspecified
0.000 0.197 0.803
E14.8 With unspecified complications
0.000 0.202 0.798
M06.93 Rheumatoid arthritis, unspecified (Forearm)
0.000 0.212 0.788
K50-K52 Noninfective enteritis and colitis
0.779 0.220 0.001
D64.9 Anaemia, unspecified
0.000 0.226 0.774
K50 Crohn's disease [regional enteritis]
0.763 0.237 0.000
M45.X7 Ankylosing spondylitis (Lumbosacral region)
0.760 0.239 0.000
E28 Ovarian dysfunction
0.000 0.240 0.760
E40-E46 Malnutrition
0.000 0.241 0.759
H36.0 Diabetic retinopathy
0.000 0.250 0.750
E20 Hypoparathyroidism
0.000 0.251 0.749
E10.7 With multiple complications
0.000 0.251 0.749
K50.9 Crohn's disease, unspecified
0.746 0.254 0.000
K51.8 Other ulcerative colitis
0.743 0.257 0.000
E16.1 Other hypoglycaemia
0.000 0.260 0.740
E07.8 Other specified disorders of thyroid
0.000 0.264 0.736
E11.2 With renal complications
0.000 0.265 0.735
E14.2 Withrenal complications
0.000 0.266 0.734
M06.97 Rheumatoid arthritis, unspecified (Ankle and foot)
0.000 0.266 0.734
E23.6 Other disorders of pituitary gland
0.000 0.272 0.728
E25 Adrenogenital disorders
0.000 0.272 0.728
E14.5 With peripheral circulatory complications
0.000 0.275 0.725
E31 Polyglandular dysfunction
0.000 0.278 0.721
E22.0 Acromegaly and pituitary gigantism
0.000 0.280 0.720
E14.7 With multiple complications
0.000 0.283 0.717
E14.0 With coma
0.000 0.283 0.717
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.283 0.717
E00 Congenital iodine-deficiency syndrome
0.000 0.283 0.717
E12 Malnutrition-related diabetes mellitus
0.000 0.283 0.717
E11.7 With multiple complications
0.000 0.283 0.717
E05.5 Thyroid crisis or storm
0.000 0.283 0.717
E05.4 Thyrotoxicosis factitia
0.000 0.283 0.717
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.283 0.717
E03.5 Myxoedema coma
0.000 0.283 0.717
E03.4 Atrophy of thyroid (acquired)
0.000 0.283 0.717
E03.3 Postinfectious hypothyroidism
0.000 0.283 0.717
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.283 0.717
E15 Nondiabetic hypoglycaemic coma
0.000 0.283 0.717
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.283 0.717
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.283 0.717
E16.4 Abnormal secretion of gastrin
0.000 0.283 0.717
E16.3 Increased secretion of glucagon
0.000 0.283 0.717
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.283 0.717
E32 Diseases of thymus
0.000 0.283 0.717
E30 Disorders of puberty, not elsewhere classified
0.000 0.283 0.717
E27.5 Adrenomedullary hyperfunction
0.000 0.284 0.716
E27.0 Other adrenocortical overactivity
0.000 0.284 0.716
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.000 0.285 0.715
E27.3 Drug-induced adrenocortical insufficiency
0.000 0.286 0.714
E24 Cushing's syndrome
0.000 0.291 0.709
M45.X6 Ankylosing spondylitis (Lumbar region)
0.707 0.293 0.000
M45.X8 Ankylosing spondylitis (Sacral and sacrococcygeal region)
0.704 0.296 0.000
M45.X5 Ankylosing spondylitis (Thoracolumbar region)
0.704 0.296 0.000
M45.X4 Ankylosing spondylitis (Thoracic region)
0.704 0.296 0.000
M45.X3 Ankylosing spondylitis (Cervicothoracic region)
0.704 0.296 0.000
M45.X1 Ankylosing spondylitis (Occipito-atlanto-axial region)
0.704 0.296 0.000
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.000 0.302 0.698
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.303 0.697
E11.8 With unspecified complications
0.000 0.310 0.690
E27.2 Addisonian crisis
0.000 0.311 0.689
E14.4 With neurological complications
0.000 0.323 0.677
K50.0 Crohn's disease of small intestine
0.672 0.328 0.000
E27.8 Other specified disorders of adrenal gland
0.000 0.335 0.664
E13 Other specified diabetes mellitus
0.000 0.346 0.653
E03.1 Congenital hypothyroidism without goitre
0.000 0.349 0.651
K90 Intestinal malabsorption
0.000 0.349 0.651
E34 Other endocrine disorders
0.000 0.351 0.649
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.000 0.352 0.648
E23.1 Drug-induced hypopituitarism
0.000 0.352 0.648
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.359 0.641
E05.8 Other thyrotoxicosis
0.000 0.362 0.638
E06 Thyroiditis
0.000 0.365 0.635
M45.X2 Ankylosing spondylitis (Cervical region)
0.631 0.369 0.000
E26 Hyperaldosteronism
0.000 0.369 0.631
M06.98 Rheumatoid arthritis, unspecified (Other)
0.000 0.369 0.631
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.372 0.628
M06 Other rheumatoid arthritis
0.000 0.374 0.625
E21.3 Hyperparathyroidism, unspecified
0.000 0.376 0.624
E22.8 Other hyperfunction of pituitary gland
0.000 0.387 0.613
E03.8 Other specified hypothyroidism
0.000 0.396 0.604
M06.3 Rheumatoid nodule
0.000 0.396 0.603
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.401 0.599
E07.1 Dyshormogenetic goitre
0.000 0.411 0.588
E07.0 Hypersecretion of calcitonin
0.000 0.411 0.588
E28.3 Primary ovarian failure
0.000 0.413 0.587
E46 Unspecified protein-energy malnutrition
0.000 0.414 0.586
K50.1 Crohn's disease of large intestine
0.583 0.417 0.000
E20.9 Hypoparathyroidism, unspecified
0.000 0.430 0.570
K51.1 Ulcerative (chronic) ileocolitis
0.567 0.432 0.000
E29 Testicular dysfunction
0.000 0.434 0.566
M06.32 Rheumatoid nodule (Upper arm)
0.000 0.437 0.563
E22.1 Hyperprolactinaemia
0.000 0.444 0.556
E24.2 Drug-induced Cushing's syndrome
0.000 0.451 0.549
E24.0 Pituitary-dependent Cushing's disease
0.000 0.452 0.548
M06.34 Rheumatoid nodule (Hand)
0.000 0.454 0.546
E28.2 Polycystic ovarian syndrome
0.000 0.455 0.545
E28.9 Ovarian dysfunction, unspecified
0.000 0.455 0.545
E28.8 Other ovarian dysfunction
0.000 0.455 0.545
E28.1 Androgen excess
0.000 0.455 0.545
E28.0 Oestrogen excess
0.000 0.455 0.545
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.456 0.544
E45 Retarded development following protein-energy malnutrition
0.000 0.456 0.544
E43 Unspecified severe protein-energy malnutrition
0.000 0.456 0.544
E42 Marasmic kwashiorkor
0.000 0.456 0.544
E41 Nutritional marasmus
0.000 0.456 0.544
E40 Kwashiorkor
0.000 0.456 0.544
E20.8 Other hypoparathyroidism
0.000 0.463 0.537
E20.1 Pseudohypoparathyroidism
0.000 0.463 0.537
E20.0 Idiopathic hypoparathyroidism
0.000 0.463 0.537
E06.3 Autoimmune thyroiditis
0.000 0.463 0.537
E11.4 With neurological complications
0.000 0.464 0.536
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.000 0.467 0.533
K90.8 Other intestinal malabsorption
0.000 0.474 0.526
E31.0 Autoimmune polyglandular failure
0.000 0.478 0.522
E25.9 Adrenogenital disorder, unspecified
0.000 0.478 0.522
E25.8 Other adrenogenital disorders
0.000 0.478 0.522
E31.9 Polyglandular dysfunction, unspecified
0.000 0.483 0.517
E31.8 Other polyglandular dysfunction
0.000 0.483 0.517
E31.1 Polyglandular hyperfunction
0.000 0.483 0.517
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.000 0.486 0.514
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.000 0.486 0.514
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.000 0.486 0.514
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.000 0.486 0.514
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.486 0.514
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.000 0.486 0.514
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.000 0.486 0.514
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.000 0.486 0.514
E12.9 Without complications
0.000 0.486 0.514
E12.8 With unspecified complications
0.000 0.486 0.514
E12.7 With multiple complications
0.000 0.486 0.514
E12.6 With other specified complications
0.000 0.486 0.514
E12.5 With peripheral circulatory complications
0.000 0.486 0.514
E12.4 With neurological complications
0.000 0.486 0.514
E12.3 With ophthalmic complications
0.000 0.486 0.514
E12.2 With renal complications
0.000 0.486 0.514
E12.1 With ketoacidosis
0.000 0.486 0.514
E12.0 With coma
0.000 0.486 0.514
E30.9 Disorder of puberty, unspecified
0.000 0.486 0.514
E30.8 Other disorders of puberty
0.000 0.486 0.514
E30.1 Precocious puberty
0.000 0.486 0.514
E30.0 Delayed puberty
0.000 0.486 0.514
E32.9 Disease of thymus, unspecified
0.000 0.486 0.514
E32.8 Other diseases of thymus
0.000 0.486 0.514
E32.1 Abscess of thymus
0.000 0.486 0.514
E32.0 Persistent hyperplasia of thymus
0.000 0.486 0.514
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.486 0.514
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.486 0.514
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.486 0.514
E24.8 Other Cushing's syndrome
0.000 0.488 0.512
E11.6 With other specified complications
0.000 0.491 0.509
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.000 0.491 0.509
E24.3 Ectopic ACTH syndrome
0.000 0.491 0.509
E24.1 Nelson's syndrome
0.000 0.491 0.509
E21.5 Disorder of parathyroid gland, unspecified
0.000 0.494 0.506
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.000 0.495 0.505
E21.4 Other specified disorders of parathyroid gland
0.000 0.499 0.501
K90.9 Intestinal malabsorption, unspecified
0.000 0.502 0.498
E34.9 Endocrine disorder, unspecified
0.000 0.507 0.493
E34.8 Other specified endocrine disorders
0.000 0.517 0.483
M06.8 Other specified rheumatoid arthritis
0.000 0.523 0.476
K51.0 Ulcerative (chronic) enterocolitis
0.472 0.528 0.000
E07.9 Disorder of thyroid, unspecified
0.000 0.529 0.471
E13.8 With unspecified complications
0.000 0.531 0.469
E13.7 With multiple complications
0.000 0.531 0.469
E13.6 With other specified complications
0.000 0.531 0.469
E13.5 With peripheral circulatory complications
0.000 0.531 0.469
E13.4 With neurological complications
0.000 0.531 0.469
E13.2 With renal complications
0.000 0.531 0.469
E13.1 With ketoacidosis
0.000 0.531 0.469
E13.0 With coma
0.000 0.531 0.469
E26.9 Hyperaldosteronism, unspecified
0.000 0.532 0.468
K90.3 Pancreatic steatorrhoea
0.000 0.533 0.466
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.533 0.466
K90.1 Tropical sprue
0.000 0.533 0.466
E13.3 With ophthalmic complications
0.000 0.533 0.466
E34.5 Androgen resistance syndrome
0.000 0.534 0.465
E34.4 Constitutional tall stature
0.000 0.534 0.465
E34.2 Ectopic hormone secretion, not elsewhere classified
0.000 0.534 0.465
E34.1 Other hypersecretion of intestinal hormones
0.000 0.534 0.465
E21.2 Other hyperparathyroidism
0.000 0.542 0.458
E06.4 Drug-induced thyroiditis
0.000 0.545 0.455
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.545 0.455
E06.0 Acute thyroiditis
0.000 0.545 0.455
E26.8 Other hyperaldosteronism
0.000 0.547 0.453
E26.1 Secondary hyperaldosteronism
0.000 0.547 0.453
M06.37 Rheumatoid nodule (Ankle and foot)
0.000 0.549 0.451
M06.2 Rheumatoid bursitis
0.000 0.551 0.448
M06.1 Adult-onset Still's disease
0.000 0.551 0.448
E06.5 Other chronic thyroiditis
0.000 0.567 0.433
M06.39 Rheumatoid nodule (Site unspecified)
0.000 0.567 0.433
M06.38 Rheumatoid nodule (Other)
0.000 0.567 0.433
M06.36 Rheumatoid nodule (Lower leg)
0.000 0.567 0.433
M06.35 Rheumatoid nodule (Pelvic region and thigh)
0.000 0.567 0.433
M06.31 Rheumatoid nodule (Shoulder region)
0.000 0.567 0.433
E34.3 Short stature, not elsewhere classified
0.000 0.570 0.430
M06.30 Rheumatoid nodule (Multiple sites)
0.000 0.572 0.428
E65-E68 Obesity and other hyperalimentation
0.000 0.592 0.408
E13.9 Without complications
0.000 0.592 0.408
E29.8 Other testicular dysfunction
0.000 0.594 0.406
E29.0 Testicular hyperfunction
0.000 0.594 0.406
H36 Retinal disorders in diseases classified elsewhere
0.000 0.599 0.401
D64 Other anaemias
0.000 0.599 0.401
E06.1 Subacute thyroiditis
0.000 0.599 0.401
E21.0 Primary hyperparathyroidism
0.000 0.601 0.399
G35 Multiple sclerosis
0.395 0.605 0.000
E29.9 Testicular dysfunction, unspecified
0.000 0.607 0.392
E44.1 Mild protein-energy malnutrition
0.000 0.610 0.390
E44.0 Moderate protein-energy malnutrition
0.000 0.610 0.390
M06.33 Rheumatoid nodule (Forearm)
0.000 0.614 0.386
E24.9 Cushing's syndrome, unspecified
0.000 0.620 0.379
E34.0 Carcinoid syndrome
0.000 0.624 0.376
K50.8 Other Crohn's disease
0.375 0.625 0.000
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.000 0.626 0.374
M06.89 Other specified rheumatoid arthritis (Site unspecified)
0.000 0.643 0.356
M06.80 Other specified rheumatoid arthritis (Multiple sites)
0.000 0.644 0.356
K75.4 Autoimmune hepatitis
0.000 0.650 0.350
M06.4 Inflammatory polyarthropathy
0.000 0.650 0.350
E26.0 Primary hyperaldosteronism
0.000 0.657 0.343
M06.88 Other specified rheumatoid arthritis (Other)
0.000 0.658 0.342
M06.87 Other specified rheumatoid arthritis (Ankle and foot)
0.000 0.658 0.342
M06.86 Other specified rheumatoid arthritis (Lower leg)
0.000 0.658 0.342
M06.85 Other specified rheumatoid arthritis (Pelvic region and thigh)
0.000 0.658 0.342
M06.84 Other specified rheumatoid arthritis (Hand)
0.000 0.658 0.342
M06.83 Other specified rheumatoid arthritis (Forearm)
0.000 0.658 0.342
M06.82 Other specified rheumatoid arthritis (Upper arm)
0.000 0.658 0.342
M06.81 Other specified rheumatoid arthritis (Shoulder region)
0.000 0.658 0.342
J45 Asthma
0.000 0.663 0.337
G35-G37 Demyelinating diseases of the central nervous system
0.333 0.667 0.000
K75 Other inflammatory liver diseases
0.000 0.674 0.326
M06.19 Adult-onset Still's disease (Site unspecified)
0.000 0.678 0.322
M06.18 Adult-onset Still's disease (Other)
0.000 0.678 0.322
M06.17 Adult-onset Still's disease (Ankle and foot)
0.000 0.678 0.322
M06.16 Adult-onset Still's disease (Lower leg)
0.000 0.678 0.322
M06.15 Adult-onset Still's disease (Pelvic region and thigh)
0.000 0.678 0.322
M06.14 Adult-onset Still's disease (Hand)
0.000 0.678 0.322
M06.13 Adult-onset Still's disease (Forearm)
0.000 0.678 0.322
M06.12 Adult-onset Still's disease (Upper arm)
0.000 0.678 0.322
M06.11 Adult-onset Still's disease (Shoulder region)
0.000 0.678 0.322
M06.10 Adult-onset Still's disease (Multiple sites)
0.000 0.678 0.322
M06.29 Rheumatoid bursitis (Site unspecified)
0.000 0.678 0.322
M06.28 Rheumatoid bursitis (Other)
0.000 0.678 0.322
M06.27 Rheumatoid bursitis (Ankle and foot)
0.000 0.678 0.322
M06.26 Rheumatoid bursitis (Lower leg)
0.000 0.678 0.322
M06.25 Rheumatoid bursitis (Pelvic region and thigh)
0.000 0.678 0.322
M06.24 Rheumatoid bursitis (Hand)
0.000 0.678 0.322
M06.23 Rheumatoid bursitis (Forearm)
0.000 0.678 0.322
M06.22 Rheumatoid bursitis (Upper arm)
0.000 0.678 0.322
M06.21 Rheumatoid bursitis (Shoulder region)
0.000 0.678 0.322
M06.20 Rheumatoid bursitis (Multiple sites)
0.000 0.678 0.322
G37 Other demyelinating diseases of central nervous system
0.319 0.681 0.000
E50-E64 Other nutritional deficiencies
0.000 0.682 0.318
K74 Fibrosis and cirrhosis of liver
0.000 0.692 0.308
G37.9 Demyelinating disease of central nervous system, unspecified
0.308 0.692 0.000
E06.9 Thyroiditis, unspecified
0.000 0.692 0.307
K70-K77 Diseases of liver
0.000 0.692 0.308
K74.3 Primary biliary cirrhosis
0.000 0.697 0.303
K75.8 Other specified inflammatory liver diseases
0.000 0.701 0.299
E67 Other hyperalimentation
0.000 0.707 0.293
E68 Sequelae of hyperalimentation
0.000 0.707 0.293
D64.0 Hereditary sideroblastic anaemia
0.000 0.709 0.291
K73 Chronic hepatitis, not elsewhere classified
0.000 0.709 0.291
H36.8 Other retinal disorders in diseases classified elsewhere
0.000 0.712 0.288
D64.4 Congenital dyserythropoietic anaemia
0.000 0.712 0.288
D64.3 Other sideroblastic anaemias
0.000 0.712 0.288
D64.2 Secondary sideroblastic anaemia due to drugs and toxins
0.000 0.712 0.288
D64.1 Secondary sideroblastic anaemia due to disease
0.000 0.712 0.288
E29.1 Testicular hypofunction
0.000 0.721 0.279
K74.5 Biliary cirrhosis, unspecified
0.000 0.721 0.279
E65 Localised adiposity
0.000 0.736 0.264
K73.2 Chronic active hepatitis, not elsewhere classified
0.000 0.738 0.262
K73.9 Chronic hepatitis, unspecified
0.000 0.740 0.260
G36 Other acute disseminated demyelination
0.254 0.745 0.000
M06.46 Inflammatory polyarthropathy (Lower leg)
0.000 0.746 0.253
M06.48 Inflammatory polyarthropathy (Other)
0.000 0.749 0.251
M06.47 Inflammatory polyarthropathy (Ankle and foot)
0.000 0.749 0.251
M06.45 Inflammatory polyarthropathy (Pelvic region and thigh)
0.000 0.749 0.251
M06.44 Inflammatory polyarthropathy (Hand)
0.000 0.749 0.251
M06.43 Inflammatory polyarthropathy (Forearm)
0.000 0.749 0.251
M06.42 Inflammatory polyarthropathy (Upper arm)
0.000 0.749 0.251
M06.41 Inflammatory polyarthropathy (Shoulder region)
0.000 0.749 0.251
M06.40 Inflammatory polyarthropathy (Multiple sites)
0.000 0.749 0.251
J45.8 Mixed asthma
0.000 0.751 0.248
K75.3 Granulomatous hepatitis, not elsewhere classified
0.000 0.752 0.248
J45.1 Nonallergic asthma
0.000 0.753 0.247
E23.0 Hypopituitarism
0.000 0.754 0.246
E51 Thiamine deficiency
0.000 0.755 0.245
D64.8 Other specified anaemias
0.000 0.757 0.243
G37.3 Acute transverse myelitis in demyelinating disease of central nervous system
0.242 0.758 0.000
K71 Toxic liver disease
0.000 0.762 0.238
K75.2 Nonspecific reactive hepatitis
0.000 0.766 0.234
K75.1 Phlebitis of portal vein
0.000 0.766 0.234
K74.0 Hepatic fibrosis
0.000 0.767 0.233
G37.5 Concentric sclerosis [Balo]
0.229 0.771 0.000
G37.4 Subacute necrotising myelitis
0.229 0.771 0.000
G37.2 Central pontine myelinolysis
0.229 0.771 0.000
G37.1 Central demyelination of corpus callosum
0.229 0.771 0.000
G37.0 Diffuse sclerosis
0.229 0.771 0.000
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.772 0.228
E63 Other nutritional deficiencies
0.000 0.772 0.228
E50 Vitamin A deficiency
0.000 0.772 0.228
E60 Dietary zinc deficiency
0.000 0.772 0.228
E59 Dietary selenium deficiency
0.000 0.772 0.228
E52 Niacin deficiency [pellagra]
0.000 0.772 0.228
K72 Hepatic failure, not elsewhere classified
0.000 0.774 0.226
G37.8 Other specified demyelinating diseases of central nervous system
0.224 0.776 0.000
K74.1 Hepatic sclerosis
0.000 0.777 0.223
K74.4 Secondary biliary cirrhosis
0.000 0.779 0.221
K74.2 Hepatic fibrosis with hepatic sclerosis
0.000 0.779 0.221
K77 Liver disorders in diseases classified elsewhere
0.000 0.779 0.221
E54 Ascorbic acid deficiency
0.000 0.779 0.220
K74.6 Other and unspecified cirrhosis of liver
0.000 0.784 0.216
E58 Dietary calcium deficiency
0.000 0.785 0.215
H20.9 Iridocyclitis, unspecified
0.214 0.786 0.000
E67.8 Other specified hyperalimentation
0.000 0.790 0.210
E67.3 Hypervitaminosis D
0.000 0.790 0.210
E67.2 Megavitamin-B6 syndrome
0.000 0.790 0.210
E67.1 Hypercarotenaemia
0.000 0.790 0.210
E67.0 Hypervitaminosis A
0.000 0.790 0.210
K73.1 Chronic lobular hepatitis, not elsewhere classified
0.000 0.791 0.209
K73.0 Chronic persistent hepatitis, not elsewhere classified
0.000 0.791 0.209
E56 Other vitamin deficiencies
0.000 0.791 0.208
K52 Other non-infective gastro-enteritis and colitis
0.207 0.792 0.001
E61 Deficiency of other nutrient elements
0.000 0.795 0.205
D60-D64 Aplastic and other anaemias
0.000 0.796 0.204
K71.0 Toxic liver disease with cholestasis
0.000 0.799 0.201
G36.0 Neuromyelitis optica [Devic]
0.198 0.802 0.000
K73.8 Other chronic hepatitis, not elsewhere classified
0.000 0.803 0.197
E51.2 Wernicke's encephalopathy
0.000 0.807 0.193
D62 Acute posthaemorrhagic anaemia
0.000 0.810 0.190
J45.0 Predominantly allergic asthma
0.000 0.810 0.190
K72.9 Hepatic failure, unspecified
0.000 0.815 0.185
G36.9 Acute disseminated demyelination, unspecified
0.183 0.817 0.000
G36.8 Other specified acute disseminated demyelination
0.183 0.817 0.000
G36.1 Acute and subacute haemorrhagic leukoencephalitis [Hurst]
0.183 0.817 0.000
H20 Iridocyclitis
0.178 0.822 0.000
K52.3 Indeterminate colitis
0.177 0.823 0.000
E51.9 Thiamine deficiency, unspecified
0.000 0.824 0.176
E51.8 Other manifestations of thiamine deficiency
0.000 0.824 0.176
E51.1 Beriberi
0.000 0.824 0.176
E55 Vitamin D deficiency
0.000 0.829 0.171
K71.8 Toxic liver disease with other disorders of liver
0.000 0.829 0.171
K71.7 Toxic liver disease with fibrosis and cirrhosis of liver
0.000 0.829 0.171
K71.5 Toxic liver disease with chronic active hepatitis
0.000 0.829 0.171
K71.4 Toxic liver disease with chronic lobular hepatitis
0.000 0.829 0.171
K71.3 Toxic liver disease with chronic persistent hepatitis
0.000 0.829 0.171
K71.2 Toxic liver disease with acute hepatitis
0.000 0.829 0.171
K71.1 Toxic liver disease with hepatic necrosis
0.000 0.831 0.169
K71.9 Toxic liver disease, unspecified
0.000 0.834 0.166
K72.1 Chronic hepatic failure
0.000 0.835 0.165
E50.9 Vitamin A deficiency, unspecified
0.000 0.836 0.164
E50.8 Other manifestations of vitamin A deficiency
0.000 0.836 0.164
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.836 0.164
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.836 0.164
E50.5 Vitamin A deficiency with night blindness
0.000 0.836 0.164
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.836 0.164
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.836 0.164
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.836 0.164
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.836 0.164
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.836 0.164
E63.9 Nutritional deficiency, unspecified
0.000 0.836 0.164
E63.8 Other specified nutritional deficiencies
0.000 0.836 0.164
E63.1 Imbalance of constituents of food intake
0.000 0.836 0.164
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.836 0.164
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.836 0.164
E64.8 Sequelae of other nutritional deficiencies
0.000 0.836 0.164
E64.3 Sequelae of rickets
0.000 0.836 0.164
E64.2 Sequelae of vitamin C deficiency
0.000 0.836 0.164
E64.1 Sequelae of vitamin A deficiency
0.000 0.836 0.164
E64.0 Sequelae of protein-energy malnutrition
0.000 0.836 0.164
K52.0 Gastro-enteritis and colitis due to radiation
0.162 0.838 0.001
K77.8 Liver disorders in other diseases classified elsewhere
0.000 0.841 0.158
K77.0 Liver disorders in infectious and parasitic diseases classified elsewhere
0.000 0.841 0.158
K71.6 Toxic liver disease with hepatitis, not elsewhere classified
0.000 0.844 0.156
E61.1 Iron deficiency
0.000 0.844 0.156
K75.0 Abscess of liver
0.000 0.845 0.154
K75.9 Inflammatory liver disease, unspecified
0.000 0.847 0.153
H30-H36 Disorders of choroid and retina
0.000 0.849 0.151
K52.2 Allergic and dietetic gastro-enteritis and colitis
0.150 0.849 0.001
E56.9 Vitamin deficiency, unspecified
0.000 0.850 0.150
E56.8 Deficiency of other vitamins
0.000 0.850 0.150
E56.0 Deficiency of vitamin E
0.000 0.850 0.150
H20.8 Other iridocyclitis
0.148 0.852 0.000
M06.49 Inflammatory polyarthropathy (Site unspecified)
0.001 0.852 0.147
E61.9 Deficiency of nutrient element, unspecified
0.000 0.853 0.147
E61.8 Deficiency of other specified nutrient elements
0.000 0.853 0.147
E61.7 Deficiency of multiple nutrient elements
0.000 0.853 0.147
E61.6 Vanadium deficiency
0.000 0.853 0.147
E61.5 Molybdenum deficiency
0.000 0.853 0.147
E61.4 Chromium deficiency
0.000 0.853 0.147
E61.3 Manganese deficiency
0.000 0.853 0.147
E61.0 Copper deficiency
0.000 0.853 0.147
H20.1 Chronic iridocyclitis
0.146 0.854 0.000
D60 Acquired pure red cell aplasia [erythroblastopenia]
0.000 0.854 0.146
H20.0 Acute and subacute iridocyclitis
0.145 0.855 0.000
D61 Other aplastic anaemias
0.000 0.863 0.137
E83 Disorders of mineral metabolism
0.123 0.865 0.012
E56.1 Deficiency of vitamin K
0.000 0.870 0.130
H34 Retinal vascular occlusions
0.000 0.870 0.130
K72.0 Acute and subacute hepatic failure
0.000 0.870 0.129
H20.2 Lens-induced iridocyclitis
0.127 0.872 0.000
M06.0 Seronegative rheumatoid arthritis
0.001 0.873 0.126
H30 Chorioretinal inflammation
0.000 0.877 0.123
E55.0 Rickets, active
0.000 0.877 0.123
E53 Deficiency of other B group vitamins
0.000 0.878 0.122
K52.1 Toxic gastro-enteritis and colitis
0.118 0.881 0.001
D61.1 Drug-induced aplastic anaemia
0.000 0.885 0.115
H35 Other retinal disorders
0.000 0.886 0.113
H35.8 Other specified retinal disorders
0.000 0.887 0.113
E70-E90 Metabolic disorders
0.001 0.887 0.112
E61.2 Magnesium deficiency
0.000 0.890 0.109
H32 Chorioretinal disorders in diseases classified elsewhere
0.000 0.891 0.109
H34.8 Other retinal vascular occlusions
0.000 0.893 0.107
D60.9 Acquired pure red cell aplasia, unspecified
0.000 0.895 0.105
D60.8 Other acquired pure red cell aplasias
0.000 0.895 0.105
D60.1 Transient acquired pure red cell aplasia
0.000 0.895 0.105
D60.0 Chronic acquired pure red cell aplasia
0.000 0.895 0.105
H34.1 Central retinal artery occlusion
0.000 0.895 0.105
H30.9 Chorioretinal inflammation, unspecified
0.000 0.897 0.103
H35.4 Peripheral retinal degeneration
0.000 0.897 0.103
H35.6 Retinal haemorrhage
0.000 0.900 0.100
D61.8 Other specified aplastic anaemias
0.000 0.902 0.098
D61.3 Idiopathic aplastic anaemia
0.000 0.902 0.098
D61.2 Aplastic anaemia due to other external agents
0.000 0.902 0.098
E74 Other disorders of carbohydrate metabolism
0.001 0.903 0.097
E83.8 Other disorders of mineral metabolism
0.089 0.903 0.009
E83.2 Disorders of zinc metabolism
0.089 0.903 0.009
E83.0 Disorders of copper metabolism
0.089 0.903 0.009
H34.9 Retinal vascular occlusion, unspecified
0.000 0.903 0.096
E83.9 Disorder of mineral metabolism, unspecified
0.085 0.906 0.009
H34.0 Transient retinal artery occlusion
0.000 0.907 0.093
M06.08 Seronegative rheumatoid arthritis (Other)
0.001 0.909 0.091
M06.04 Seronegative rheumatoid arthritis (Hand)
0.001 0.909 0.091
M06.03 Seronegative rheumatoid arthritis (Forearm)
0.001 0.909 0.091
M06.02 Seronegative rheumatoid arthritis (Upper arm)
0.001 0.909 0.091
E04 Other non-toxic goitre
0.000 0.909 0.091
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.000 0.910 0.090
H34.2 Other retinal artery occlusions
0.000 0.911 0.089

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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