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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs2254386
log Bayes Factor = 103.624
Chromosome 6   position 31,425,033  (GRCh37) Explore rs2254386 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E03.9 Hypothyroidism, unspecified
0.000 0.000 1.000
E05.9 Thyrotoxicosis, unspecified
0.000 0.000 1.000
K90.0 Coeliac disease
0.000 0.000 1.000
M45.X9 Ankylosing spondylitis (Site unspecified)
0.000 0.000 1.000
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.000 1.000
E03 Other hypothyroidism
0.000 0.000 1.000
E00-E07 Disorders of thyroid gland
0.000 0.000 1.000
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.002 0.998
M45 Ankylosing spondylitis
0.000 0.005 0.995
M45.X0 Ankylosing spondylitis (Multiple sites in spine)
0.000 0.010 0.990
E07 Other disorders of thyroid
0.000 0.072 0.928
M45.X2 Ankylosing spondylitis (Cervical region)
0.000 0.072 0.928
E83.1 Disorders of iron metabolism
0.909 0.091 0.000
C85 Other and unspecified types of non-Hodgkin's lymphoma
0.000 0.114 0.886
C85.9 Non-Hodgkin's lymphoma, unspecified type
0.000 0.115 0.885
E07.9 Disorder of thyroid, unspecified
0.000 0.115 0.885
C85.1 B-cell lymphoma, unspecified
0.000 0.119 0.881
E03.8 Other specified hypothyroidism
0.000 0.124 0.876
E06 Thyroiditis
0.000 0.130 0.870
C81-C96 Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissue
0.000 0.140 0.860
C82 Follicular [nodular] non-Hodgkin's lymphoma
0.000 0.145 0.855
C83.3 Large cell (diffuse)
0.000 0.151 0.849
C83 Diffuse non-Hodgkin's lymphoma
0.000 0.155 0.845
C82.9 Follicular non-Hodgkin's lymphoma, unspecified
0.000 0.161 0.839
J45.9 Asthma, unspecified
0.000 0.168 0.832
M45.X6 Ankylosing spondylitis (Lumbar region)
0.000 0.231 0.769
E05.8 Other thyrotoxicosis
0.000 0.254 0.746
E06.3 Autoimmune thyroiditis
0.000 0.258 0.742
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.277 0.723
E05.5 Thyroid crisis or storm
0.000 0.283 0.717
E05.4 Thyrotoxicosis factitia
0.000 0.283 0.717
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.283 0.717
E03.5 Myxoedema coma
0.000 0.283 0.717
E03.4 Atrophy of thyroid (acquired)
0.000 0.283 0.717
E03.3 Postinfectious hypothyroidism
0.000 0.283 0.717
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.283 0.717
E00 Congenital iodine-deficiency syndrome
0.000 0.283 0.717
M45.X8 Ankylosing spondylitis (Sacral and sacrococcygeal region)
0.000 0.286 0.713
M45.X7 Ankylosing spondylitis (Lumbosacral region)
0.000 0.286 0.713
M45.X5 Ankylosing spondylitis (Thoracolumbar region)
0.000 0.286 0.713
M45.X4 Ankylosing spondylitis (Thoracic region)
0.000 0.286 0.713
M45.X3 Ankylosing spondylitis (Cervicothoracic region)
0.000 0.286 0.713
M45.X1 Ankylosing spondylitis (Occipito-atlanto-axial region)
0.000 0.286 0.713
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.288 0.712
C82.7 Other types of follicular non-Hodgkin's lymphoma
0.000 0.295 0.705
C82.3 Follicular lymphoma grade IIIa
0.000 0.298 0.702
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.301 0.699
C82.2 Large cell, follicular
0.000 0.321 0.679
C81 Hodgkin's disease
0.000 0.323 0.677
C82.0 Small cleaved cell, follicular
0.000 0.331 0.669
C82.4 Follicular lymphoma grade IIIb
0.000 0.334 0.666
E07.1 Dyshormogenetic goitre
0.000 0.334 0.666
E07.0 Hypersecretion of calcitonin
0.000 0.334 0.666
E03.1 Congenital hypothyroidism without goitre
0.000 0.334 0.665
C83.7 Burkitt's tumour
0.000 0.336 0.664
E06.9 Thyroiditis, unspecified
0.000 0.344 0.656
C86 Other specified types of T/NK-cell lymphoma
0.000 0.348 0.652
E06.5 Other chronic thyroiditis
0.000 0.349 0.651
C84 Peripheral and cutaneous T-cell lymphomas
0.000 0.349 0.651
E06.1 Subacute thyroiditis
0.000 0.364 0.636
C85.0 Lymphosarcoma
0.000 0.364 0.636
E06.4 Drug-induced thyroiditis
0.000 0.376 0.624
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.376 0.624
E06.0 Acute thyroiditis
0.000 0.376 0.624
E07.8 Other specified disorders of thyroid
0.000 0.378 0.622
C85.2 Mediastinal (thymic) large B-cell lymphoma
0.000 0.381 0.619
C96 Other and unspecified malignant neoplasms of lymphoid, haematopoietic and related tissue
0.000 0.383 0.617
C82.6 Cutaneous follicle centre lymphoma
0.000 0.387 0.613
C82.5 Diffuse follicle centre lymphoma
0.000 0.387 0.613
C88 Malignant immunoproliferative diseases
0.000 0.389 0.611
C83.6 Undifferentiated (diffuse)
0.000 0.394 0.606
C83.5 Lymphoblastic (diffuse)
0.000 0.394 0.606
C83.4 Immunoblastic (diffuse)
0.000 0.394 0.606
C83.2 Mixed small and large cell (diffuse)
0.000 0.394 0.606
C81.9 Hodgkin's disease, unspecified
0.000 0.395 0.605
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.399 0.600
C94 Other leukaemias of specified cell type
0.000 0.436 0.564
C95 Leukaemia of unspecified cell type
0.000 0.449 0.551
C83.9 Diffuse non-Hodgkin's lymphoma, unspecified
0.000 0.454 0.546
C83.1 Small cleaved cell (diffuse)
0.000 0.465 0.535
C84.8 Cutaneous T-cell lymphoma, unspecified
0.000 0.478 0.522
C93 Monocytic leukaemia
0.000 0.479 0.521
C81.2 Mixed cellularity
0.000 0.485 0.515
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.000 0.486 0.514
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.000 0.486 0.514
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.000 0.486 0.514
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.000 0.486 0.514
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.486 0.514
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.000 0.486 0.514
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.000 0.486 0.514
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.000 0.486 0.514
C86.5 Angioimmunoblastic T-cell lymphoma
0.000 0.497 0.503
C88.4 Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue [MALT-lymphoma]
0.000 0.503 0.497
C82.1 Mixed small cleaved and large cell, follicular
0.000 0.507 0.493
C84.5 Other and unspecified T-cell lymphomas
0.000 0.513 0.487
C81.4 Lymphocyte-rich classical Hodgkin lymphoma
0.000 0.515 0.485
C81.3 Lymphocytic depletion
0.000 0.515 0.485
C84.0 Mycosis fungoides
0.000 0.518 0.481
C81.7 Other Hodgkin's disease
0.000 0.529 0.471
C86.6 Primary cutaneous CD30-positive T-cell proliferations
0.000 0.532 0.467
C86.4 Blastic NK-cell lymphoma
0.000 0.532 0.467
C86.3 Subcutaneous panniculitis-like T-cell lymphoma
0.000 0.532 0.467
C86.2 Enteropathy-type (intestinal) T-cell lymphoma
0.000 0.532 0.467
C86.1 Hepatosplenic T-cell lymphoma
0.000 0.532 0.467
C86.0 Extranodal NK/T-cell lymphoma, nasal type
0.000 0.532 0.467
C84.9 Mature T/NK-cell lymphoma, unspecified
0.000 0.533 0.467
C84.7 Anaplastic large cell lymphoma, ALK-negative
0.000 0.533 0.467
C84.6 Anaplastic large cell lymphoma, ALK-positive
0.000 0.533 0.467
C84.3 Lymphoepithelioid lymphoma
0.000 0.533 0.467
C84.2 T-zone lymphoma
0.000 0.533 0.467
C84.1 Sezary's diease
0.000 0.533 0.467
C96.9 Malignant neoplasms of lymphoid, haematopoietic and related tissue, unspecified
0.000 0.557 0.442
C96.8 Histiocytic sarcoma
0.000 0.557 0.442
C96.7 Other specified malignant neoplasms of lymphoid, haematopoietic and related tissue
0.000 0.557 0.442
C96.6 Unifocal Langerhans-cell histiocytosis
0.000 0.557 0.442
C96.5 Multifocal and unisystemic Langerhans-cell histiocytosis
0.000 0.557 0.442
C96.4 Sarcoma of dendritic cells (accessory cells)
0.000 0.557 0.442
C96.3 True histiocytic lymphoma
0.000 0.557 0.442
C96.2 Malignant mast cell tumour
0.000 0.557 0.442
C96.1 Malignant histiocytosis
0.000 0.557 0.442
C96.0 Letterer-Siwe disease
0.000 0.557 0.442
C88.9 Malignant immunoproliferative disease, unspecified
0.000 0.562 0.438
C88.7 Other malignant immunoproliferative diseases
0.000 0.562 0.438
C88.3 Immunoproliferative small intestinal disease
0.000 0.562 0.438
C88.2 Gamma heavy chain disease
0.000 0.562 0.438
C88.1 Alpha heavy chain disease
0.000 0.562 0.438
C95.9 Leukaemia, unspecified
0.000 0.574 0.425
C81.1 Nodular sclerosis
0.000 0.594 0.406
C94.7 Other specified leukaemias
0.000 0.595 0.404
C94.5 Acute myelofibrosis
0.000 0.595 0.404
C94.4 Acute panmyelosis
0.000 0.595 0.404
C94.3 Mast cell leukaemia
0.000 0.595 0.404
C94.2 Acute megakaryoblastic leukaemia
0.000 0.595 0.404
C94.1 Chronic erythraemia
0.000 0.595 0.404
C94.0 Acute erythraemia and erythroleukaemia
0.000 0.595 0.404
C91 Lymphoid leukaemia
0.000 0.596 0.404
C85.7 Other specified types of non-Hodgkin's lymphoma
0.000 0.597 0.403
C81.0 Lymphocytic predominance
0.000 0.597 0.403
C95.7 Other leukaemia of unspecified cell type
0.000 0.605 0.395
C95.2 Subacute leukaemia of unspecified cell type
0.000 0.605 0.395
K90 Intestinal malabsorption
0.000 0.609 0.391
C84.4 Peripheral T-cell lymphoma
0.000 0.610 0.390
C93.9 Monocytic leukaemia, unspecified
0.000 0.626 0.373
C93.7 Other monocytic leukaemia
0.000 0.626 0.373
C93.3 Juvenile myelomonocytic leukaemia
0.000 0.626 0.373
C93.2 Subacute monocytic leukaemia
0.000 0.626 0.373
C93.0 Acute monocytic leukaemia
0.000 0.626 0.373
C95.1 Chronic leukaemia of unspecified cell type
0.000 0.633 0.367
C94.6 Myelodysplastic and myeloproliferative disease, not elsewhere classified
0.000 0.649 0.351
C92 Myeloid leukaemia
0.000 0.657 0.343
C88.0 Waldenstrom's macroglobulinaemia
0.000 0.659 0.341
C91.9 Lymphoid leukaemia, unspecified
0.000 0.662 0.338
C91.5 Adult T-cell leukaemia
0.000 0.680 0.319
E10 Insulin-dependent diabetes mellitus
0.000 0.682 0.318
C95.0 Acute leukaemia of unspecified cell type
0.000 0.683 0.317
E10-E14 Diabetes mellitus
0.000 0.687 0.313
K90.9 Intestinal malabsorption, unspecified
0.000 0.687 0.313
E10.9 Without complications
0.000 0.689 0.311
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.692 0.308
E14 Unspecified diabetes mellitus
0.000 0.701 0.299
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.001 0.705 0.293
E14.3 With ophthalmic complications
0.000 0.706 0.294
C92.1 Chronic myeloid leukaemia
0.000 0.707 0.293
E10.3 With ophthalmic complications
0.000 0.709 0.291
C91.8 Mature B-cell leukaemia Burkitt-type
0.000 0.710 0.290
C91.7 Other lymphoid leukaemia
0.000 0.710 0.290
C91.6 Prolymphocytic leukaemia of T-cell type
0.000 0.710 0.290
C91.3 Prolymphocytic leukaemia
0.000 0.710 0.290
C91.2 Subacute lymphocytic leukaemia
0.000 0.710 0.290
C83.8 Other types of diffuse non-Hodgkin's lymphoma
0.001 0.713 0.286
E10.2 With renal complications
0.000 0.716 0.284
K90.3 Pancreatic steatorrhoea
0.000 0.719 0.280
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.719 0.280
K90.1 Tropical sprue
0.000 0.719 0.280
C93.1 Chronic monocytic leukaemia
0.001 0.722 0.277
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.000 0.723 0.277
E10.1 With ketoacidosis
0.000 0.737 0.263
C92.8 Acute myeloid leukaemia with multilineage dysplasia
0.000 0.754 0.246
C92.6 Acute myeloid leukaemia with 11q23-abnormality
0.000 0.754 0.246
C92.3 Myeloid sarcoma
0.000 0.754 0.246
C92.2 Subacute myeloid leukaemia
0.000 0.754 0.246
C91.0 Acute lymphoblastic leukaemia
0.000 0.757 0.243
E14.2 Withrenal complications
0.000 0.763 0.236
C92.5 Acute myelomonocytic leukaemia
0.000 0.766 0.234
E10.7 With multiple complications
0.000 0.770 0.230
E14.8 With unspecified complications
0.000 0.770 0.230
E10.6 With other specified complications
0.000 0.771 0.229
E10.8 With unspecified complications
0.000 0.772 0.228
E14.5 With peripheral circulatory complications
0.000 0.772 0.227
E12 Malnutrition-related diabetes mellitus
0.000 0.775 0.225
E14.1 With ketoacidosis
0.000 0.778 0.222
C92.9 Myeloid leukaemia, unspecified
0.000 0.782 0.217
E13 Other specified diabetes mellitus
0.000 0.782 0.217
E14.7 With multiple complications
0.000 0.785 0.215
E14.0 With coma
0.000 0.785 0.215
C92.7 Other myeloid leukaemia
0.000 0.785 0.214
K90.8 Other intestinal malabsorption
0.000 0.788 0.212
E14.6 With other specified complications
0.000 0.793 0.207
E10.4 With neurological complications
0.000 0.794 0.206
C90 Multiple myeloma and malignant plasma cell neoplasms
0.001 0.794 0.206
E14.4 With neurological complications
0.000 0.794 0.206
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.803 0.197
C92.4 Acute promyelocytic leukaemia
0.000 0.803 0.197
E10.5 With peripheral circulatory complications
0.000 0.808 0.192
E10.0 With coma
0.000 0.816 0.184
E04 Other non-toxic goitre
0.000 0.817 0.183
E40-E46 Malnutrition
0.000 0.819 0.181
J45 Asthma
0.000 0.820 0.180
E12.9 Without complications
0.000 0.839 0.161
E12.8 With unspecified complications
0.000 0.839 0.161
E12.7 With multiple complications
0.000 0.839 0.161
E12.6 With other specified complications
0.000 0.839 0.161
E12.5 With peripheral circulatory complications
0.000 0.839 0.161
E12.4 With neurological complications
0.000 0.839 0.161
E12.3 With ophthalmic complications
0.000 0.839 0.161
E12.2 With renal complications
0.000 0.839 0.161
E12.1 With ketoacidosis
0.000 0.839 0.161
E12.0 With coma
0.000 0.839 0.161
E13.3 With ophthalmic complications
0.000 0.841 0.158
C91.1 Chronic lymphocytic leukaemia
0.000 0.843 0.157
C91.4 Hairy-cell leukaemia
0.001 0.843 0.156
E13.8 With unspecified complications
0.000 0.844 0.156
E13.7 With multiple complications
0.000 0.844 0.156
E13.6 With other specified complications
0.000 0.844 0.156
E13.5 With peripheral circulatory complications
0.000 0.844 0.156
E13.4 With neurological complications
0.000 0.844 0.156
E13.2 With renal complications
0.000 0.844 0.156
E13.1 With ketoacidosis
0.000 0.844 0.156
E13.0 With coma
0.000 0.844 0.156
C90.1 Plasma cell leukaemia
0.001 0.853 0.146
E13.9 Without complications
0.000 0.854 0.146
E15 Nondiabetic hypoglycaemic coma
0.000 0.858 0.142
C90.3 Solitary plasmacytoma
0.001 0.861 0.139
J45.1 Nonallergic asthma
0.000 0.865 0.135
C83.0 Small cell (diffuse)
0.006 0.868 0.126
E04.8 Other specified non-toxic goitre
0.000 0.868 0.131
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.870 0.130
E45 Retarded development following protein-energy malnutrition
0.000 0.870 0.130
E43 Unspecified severe protein-energy malnutrition
0.000 0.870 0.130
E42 Marasmic kwashiorkor
0.000 0.870 0.130
E41 Nutritional marasmus
0.000 0.870 0.130
E40 Kwashiorkor
0.000 0.870 0.130
J45.8 Mixed asthma
0.000 0.874 0.126
E50-E64 Other nutritional deficiencies
0.000 0.876 0.124
E16 Other disorders of pancreatic internal secretion
0.000 0.882 0.118
E83 Disorders of mineral metabolism
0.106 0.893 0.001
E04.9 Non-toxic goitre, unspecified
0.000 0.893 0.107
E04.0 Non-toxic diffuse goitre
0.000 0.896 0.104
E58 Dietary calcium deficiency
0.000 0.898 0.102
C92.0 Acute myeloid leukaemia
0.000 0.900 0.099
E16.1 Other hypoglycaemia
0.000 0.902 0.098
E20-E35 Disorders of other endocrine glands
0.000 0.904 0.096
E04.2 Non-toxic multinodular goitre
0.000 0.905 0.095
E44.1 Mild protein-energy malnutrition
0.000 0.906 0.093
E44.0 Moderate protein-energy malnutrition
0.000 0.906 0.093
E46 Unspecified protein-energy malnutrition
0.000 0.909 0.090
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.911 0.089
E63 Other nutritional deficiencies
0.000 0.911 0.089
E50 Vitamin A deficiency
0.000 0.911 0.089
E60 Dietary zinc deficiency
0.000 0.911 0.089
E59 Dietary selenium deficiency
0.000 0.911 0.089
E52 Niacin deficiency [pellagra]
0.000 0.911 0.089
E51 Thiamine deficiency
0.000 0.912 0.088
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.915 0.085
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.915 0.085
E16.4 Abnormal secretion of gastrin
0.000 0.915 0.085
E16.3 Increased secretion of glucagon
0.000 0.915 0.085
E29 Testicular dysfunction
0.000 0.915 0.085
E54 Ascorbic acid deficiency
0.000 0.915 0.084
E56 Other vitamin deficiencies
0.000 0.916 0.084
E28 Ovarian dysfunction
0.000 0.917 0.083
E24 Cushing's syndrome
0.000 0.918 0.082
E83.9 Disorder of mineral metabolism, unspecified
0.081 0.918 0.001
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.921 0.079
C90.2 Plasmacytoma, extramedullary
0.001 0.922 0.077
E65-E68 Obesity and other hyperalimentation
0.000 0.922 0.078
E29.1 Testicular hypofunction
0.000 0.923 0.077
G35 Multiple sclerosis
0.077 0.923 0.000
E83.8 Other disorders of mineral metabolism
0.076 0.923 0.001
E83.2 Disorders of zinc metabolism
0.076 0.923 0.001
E83.0 Disorders of copper metabolism
0.076 0.923 0.001
E61 Deficiency of other nutrient elements
0.000 0.924 0.076
E83.3 Disorders of phosphorus metabolism
0.074 0.925 0.000
E55 Vitamin D deficiency
0.000 0.926 0.073
E25 Adrenogenital disorders
0.000 0.929 0.071
E28.3 Primary ovarian failure
0.000 0.929 0.071
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.931 0.069
E32 Diseases of thymus
0.000 0.931 0.069
E31 Polyglandular dysfunction
0.000 0.931 0.069
E30 Disorders of puberty, not elsewhere classified
0.000 0.931 0.069
E24.2 Drug-induced Cushing's syndrome
0.000 0.933 0.067
E24.9 Cushing's syndrome, unspecified
0.000 0.933 0.067
E14.9 Without complications
0.000 0.934 0.066
E28.2 Polycystic ovarian syndrome
0.000 0.935 0.065
E50.9 Vitamin A deficiency, unspecified
0.000 0.936 0.064
E50.8 Other manifestations of vitamin A deficiency
0.000 0.936 0.064
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.936 0.064
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.936 0.064
E50.5 Vitamin A deficiency with night blindness
0.000 0.936 0.064
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.936 0.064
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.936 0.064
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.936 0.064
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.936 0.064
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.936 0.064
E63.9 Nutritional deficiency, unspecified
0.000 0.936 0.064
E63.8 Other specified nutritional deficiencies
0.000 0.936 0.064
E63.1 Imbalance of constituents of food intake
0.000 0.936 0.064
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.936 0.064
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.936 0.064
E64.8 Sequelae of other nutritional deficiencies
0.000 0.936 0.064
E64.3 Sequelae of rickets
0.000 0.936 0.064
E64.2 Sequelae of vitamin C deficiency
0.000 0.936 0.064
E64.1 Sequelae of vitamin A deficiency
0.000 0.936 0.064
E64.0 Sequelae of protein-energy malnutrition
0.000 0.936 0.064
E24.0 Pituitary-dependent Cushing's disease
0.000 0.936 0.063
E51.9 Thiamine deficiency, unspecified
0.000 0.936 0.063
E51.8 Other manifestations of thiamine deficiency
0.000 0.936 0.063
E51.1 Beriberi
0.000 0.936 0.063
E51.2 Wernicke's encephalopathy
0.000 0.937 0.062
E29.9 Testicular dysfunction, unspecified
0.000 0.939 0.061
E29.8 Other testicular dysfunction
0.000 0.939 0.061
E29.0 Testicular hyperfunction
0.000 0.939 0.061
E23 Hypofunction and other disorders of pituitary gland
0.000 0.939 0.061
E56.9 Vitamin deficiency, unspecified
0.000 0.939 0.060
E56.8 Deficiency of other vitamins
0.000 0.939 0.060
E56.0 Deficiency of vitamin E
0.000 0.939 0.060
E28.9 Ovarian dysfunction, unspecified
0.000 0.940 0.059
E28.8 Other ovarian dysfunction
0.000 0.940 0.059
E28.1 Androgen excess
0.000 0.940 0.059
E28.0 Oestrogen excess
0.000 0.940 0.059
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.000 0.941 0.059
E24.3 Ectopic ACTH syndrome
0.000 0.941 0.059
E24.1 Nelson's syndrome
0.000 0.941 0.059
E61.2 Magnesium deficiency
0.000 0.942 0.058
E26 Hyperaldosteronism
0.000 0.943 0.056
E67 Other hyperalimentation
0.000 0.944 0.056
E68 Sequelae of hyperalimentation
0.000 0.944 0.056
E56.1 Deficiency of vitamin K
0.000 0.944 0.056
E61.9 Deficiency of nutrient element, unspecified
0.000 0.945 0.055
E61.8 Deficiency of other specified nutrient elements
0.000 0.945 0.055
E61.7 Deficiency of multiple nutrient elements
0.000 0.945 0.055
E61.6 Vanadium deficiency
0.000 0.945 0.055
E61.5 Molybdenum deficiency
0.000 0.945 0.055
E61.4 Chromium deficiency
0.000 0.945 0.055
E61.3 Manganese deficiency
0.000 0.945 0.055
E61.0 Copper deficiency
0.000 0.945 0.055
E22 Hyperfunction of pituitary gland
0.000 0.945 0.055
E24.8 Other Cushing's syndrome
0.000 0.946 0.053
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.000 0.947 0.053
E55.0 Rickets, active
0.000 0.947 0.053
E23.2 Diabetes insipidus
0.000 0.948 0.052
E25.9 Adrenogenital disorder, unspecified
0.000 0.949 0.051
E25.8 Other adrenogenital disorders
0.000 0.949 0.051
E20 Hypoparathyroidism
0.000 0.950 0.050
E30.9 Disorder of puberty, unspecified
0.000 0.950 0.049
E30.8 Other disorders of puberty
0.000 0.950 0.049
E30.1 Precocious puberty
0.000 0.950 0.049
E30.0 Delayed puberty
0.000 0.950 0.049
E31.9 Polyglandular dysfunction, unspecified
0.000 0.950 0.049
E31.8 Other polyglandular dysfunction
0.000 0.950 0.049
E31.1 Polyglandular hyperfunction
0.000 0.950 0.049
E31.0 Autoimmune polyglandular failure
0.000 0.950 0.049
E32.9 Disease of thymus, unspecified
0.000 0.950 0.049
E32.8 Other diseases of thymus
0.000 0.950 0.049
E32.1 Abscess of thymus
0.000 0.950 0.049
E32.0 Persistent hyperplasia of thymus
0.000 0.950 0.049
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.950 0.049
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.950 0.049
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.950 0.049
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.000 0.953 0.046
E53 Deficiency of other B group vitamins
0.000 0.954 0.046
G35-G37 Demyelinating diseases of the central nervous system
0.046 0.954 0.000
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.000 0.956 0.044
E23.1 Drug-induced hypopituitarism
0.000 0.956 0.044
E23.6 Other disorders of pituitary gland
0.000 0.958 0.042
E26.9 Hyperaldosteronism, unspecified
0.000 0.958 0.041
E26.8 Other hyperaldosteronism
0.000 0.959 0.041
E26.1 Secondary hyperaldosteronism
0.000 0.959 0.041
E83.5 Disorders of calcium metabolism
0.041 0.959 0.000
E67.8 Other specified hyperalimentation
0.000 0.959 0.040
E67.3 Hypervitaminosis D
0.000 0.959 0.040
E67.2 Megavitamin-B6 syndrome
0.000 0.959 0.040
E67.1 Hypercarotenaemia
0.000 0.959 0.040
E67.0 Hypervitaminosis A
0.000 0.959 0.040
E16.2 Hypoglycaemia, unspecified
0.000 0.960 0.040
G37 Other demyelinating diseases of central nervous system
0.040 0.960 0.000
J45.0 Predominantly allergic asthma
0.000 0.960 0.039
E22.8 Other hyperfunction of pituitary gland
0.000 0.960 0.039
G37.9 Demyelinating disease of central nervous system, unspecified
0.038 0.962 0.000
E55.9 Vitamin D deficiency, unspecified
0.000 0.963 0.037
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.000 0.963 0.037
E20.8 Other hypoparathyroidism
0.000 0.964 0.036
E20.0 Idiopathic hypoparathyroidism
0.000 0.964 0.036
E61.1 Iron deficiency
0.000 0.964 0.036
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.964 0.036
E23.7 Disorder of pituitary gland, unspecified
0.000 0.965 0.035
E22.1 Hyperprolactinaemia
0.000 0.965 0.034
E34 Other endocrine disorders
0.000 0.966 0.033
E20.1 Pseudohypoparathyroidism
0.000 0.967 0.033
E23.0 Hypopituitarism
0.000 0.967 0.033
E53.1 Pyridoxine deficiency
0.000 0.967 0.033
E53.0 Riboflavin deficiency
0.000 0.967 0.033
E27 Other disorders of adrenal gland
0.000 0.969 0.031
M45-M49 Spondylopathies
0.000 0.969 0.031
G36 Other acute disseminated demyelination
0.031 0.969 0.000
E04.1 Non-toxic single thyroid nodule
0.000 0.970 0.030
G37.8 Other specified demyelinating diseases of central nervous system
0.030 0.970 0.000
G37.5 Concentric sclerosis [Balo]
0.029 0.971 0.000
G37.4 Subacute necrotising myelitis
0.029 0.971 0.000
G37.2 Central pontine myelinolysis
0.029 0.971 0.000
G37.1 Central demyelination of corpus callosum
0.029 0.971 0.000
G37.0 Diffuse sclerosis
0.029 0.971 0.000
E21.4 Other specified disorders of parathyroid gland
0.000 0.972 0.028
E27.1 Primary adrenocortical insufficiency
0.000 0.972 0.028
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.000 0.972 0.028
E65 Localised adiposity
0.001 0.972 0.027
E26.0 Primary hyperaldosteronism
0.000 0.973 0.027
E53.9 Vitamin B deficiency, unspecified
0.000 0.973 0.027
E21.5 Disorder of parathyroid gland, unspecified
0.000 0.973 0.027
C90.0 Multiple myeloma
0.001 0.974 0.025
E21.2 Other hyperparathyroidism
0.000 0.974 0.026
E34.5 Androgen resistance syndrome
0.000 0.975 0.024
E34.4 Constitutional tall stature
0.000 0.975 0.024
E34.3 Short stature, not elsewhere classified
0.000 0.975 0.024
E34.2 Ectopic hormone secretion, not elsewhere classified
0.000 0.975 0.024
E34.1 Other hypersecretion of intestinal hormones
0.000 0.975 0.024
L40.9 Psoriasis, unspecified
0.024 0.976 0.000
E20.9 Hypoparathyroidism, unspecified
0.001 0.977 0.023
E27.5 Adrenomedullary hyperfunction
0.000 0.977 0.022
E27.0 Other adrenocortical overactivity
0.000 0.977 0.022
E27.3 Drug-induced adrenocortical insufficiency
0.000 0.978 0.022
G36.9 Acute disseminated demyelination, unspecified
0.022 0.978 0.000
G36.8 Other specified acute disseminated demyelination
0.022 0.978 0.000
G36.1 Acute and subacute haemorrhagic leukoencephalitis [Hurst]
0.022 0.978 0.000
K90-K93 Other diseases of the digestive system
0.000 0.978 0.022
E34.8 Other specified endocrine disorders
0.000 0.978 0.021
E22.0 Acromegaly and pituitary gigantism
0.000 0.979 0.021
M49 Spondylopathies in diseases classified elsewhere
0.000 0.979 0.021
G37.3 Acute transverse myelitis in demyelinating disease of central nervous system
0.020 0.979 0.000
E83.4 Disorders of magnesium metabolism
0.020 0.980 0.001
G36.0 Neuromyelitis optica [Devic]
0.020 0.980 0.000
E27.9 Disorder of adrenal gland, unspecified
0.000 0.982 0.018
E78.5 Hyperlipidaemia, unspecified
0.000 0.982 0.018
E34.0 Carcinoid syndrome
0.001 0.983 0.016
F20.9 Schizophrenia, unspecified
0.017 0.983 0.000
K93 Disorders of other digestive organs in diseases classified elsewhere
0.000 0.984 0.016
E21.3 Hyperparathyroidism, unspecified
0.000 0.984 0.016
E34.9 Endocrine disorder, unspecified
0.001 0.985 0.015
M49.8 Spondylopathy in other diseases classified elsewhere
0.000 0.985 0.015
M49.4 Neuropathic spondylopathy
0.000 0.985 0.015
M49.3 Spondylopathy in other infectious and parasitic diseases classified elsewhere
0.000 0.985 0.015
M49.2 Enterobacterial spondylitis
0.000 0.985 0.015
M49.1 Brucella spondylitis
0.000 0.985 0.015
M49.0 Tuberculosis of spine
0.000 0.985 0.015
E27.4 Other and unspecified adrenocortical insufficiency
0.000 0.986 0.014
M49.5 Collapsed vertebra in diseases classified elsewhere
0.000 0.986 0.014
E27.2 Addisonian crisis
0.001 0.987 0.013
M46 Other inflammatory spondylopathies
0.000 0.987 0.013
R40.2 Coma, unspecified
0.000 0.988 0.012
K93.8 Disorders of other specified digestive organs in diseases classified elsewhere
0.000 0.988 0.012
K93.1 Megacolon in Chagas' disease
0.000 0.988 0.012
K93.0 Tuberculous disorders of intestines, peritoneum and mesenteric glands
0.000 0.988 0.012
E27.8 Other specified disorders of adrenal gland
0.001 0.988 0.011
M49.09 Tuberculosis of spine (Site unspecified)
0.000 0.989 0.011
M49.08 Tuberculosis of spine (Sacral and sacrococcygeal region)
0.000 0.989 0.011
M49.07 Tuberculosis of spine (Lumbosacral region)
0.000 0.989 0.011
M49.06 Tuberculosis of spine (Lumbar region)
0.000 0.989 0.011
M49.05 Tuberculosis of spine (Thoracolumbar region)
0.000 0.989 0.011
M49.04 Tuberculosis of spine (Thoracic region)
0.000 0.989 0.011
M49.03 Tuberculosis of spine (Cervicothoracic region)
0.000 0.989 0.011
M49.02 Tuberculosis of spine (Cervical region)
0.000 0.989 0.011
M49.01 Tuberculosis of spine (Occipito-atlanto-axial region)
0.000 0.989 0.011
M49.00 Tuberculosis of spine (Multiple sites in spine)
0.000 0.989 0.011
M49.19 Brucella spondylitis (Site unspecified)
0.000 0.989 0.011
M49.18 Brucella spondylitis (Sacral and sacrococcygeal region)
0.000 0.989 0.011
M49.17 Brucella spondylitis (Lumbosacral region)
0.000 0.989 0.011
M49.16 Brucella spondylitis (Lumbar region)
0.000 0.989 0.011
M49.15 Brucella spondylitis (Thoracolumbar region)
0.000 0.989 0.011
M49.14 Brucella spondylitis (Thoracic region)
0.000 0.989 0.011
M49.13 Brucella spondylitis (Cervicothoracic region)
0.000 0.989 0.011
M49.12 Brucella spondylitis (Cervical region)
0.000 0.989 0.011
M49.11 Brucella spondylitis (Occipito-atlanto-axial region)
0.000 0.989 0.011
M49.10 Brucella spondylitis (Multiple sites in spine)
0.000 0.989 0.011
M49.29 Enterobacterial spondylitis (Site unspecified)
0.000 0.989 0.011
M49.28 Enterobacterial spondylitis (Sacral and sacrococcygeal region)
0.000 0.989 0.011
M49.27 Enterobacterial spondylitis (Lumbosacral region)
0.000 0.989 0.011
M49.26 Enterobacterial spondylitis (Lumbar region)
0.000 0.989 0.011
M49.25 Enterobacterial spondylitis (Thoracolumbar region)
0.000 0.989 0.011
M49.24 Enterobacterial spondylitis (Thoracic region)
0.000 0.989 0.011
M49.23 Enterobacterial spondylitis (Cervicothoracic region)
0.000 0.989 0.011
M49.22 Enterobacterial spondylitis (Cervical region)
0.000 0.989 0.011
M49.21 Enterobacterial spondylitis (Occipito-atlanto-axial region)
0.000 0.989 0.011
M49.20 Enterobacterial spondylitis (Multiple sites in spine)
0.000 0.989 0.011
M49.39 Spondylopathy in other infectious and parasitic diseases classified elsewhere (Site unspecified)
0.000 0.989 0.011
M49.38 Spondylopathy in other infectious and parasitic diseases classified elsewhere (Sacral and sacrococcygeal region)
0.000 0.989 0.011
M49.37 Spondylopathy in other infectious and parasitic diseases classified elsewhere (Lumbosacral region)
0.000 0.989 0.011
M49.36 Spondylopathy in other infectious and parasitic diseases classified elsewhere (Lumbar region)
0.000 0.989 0.011
M49.35 Spondylopathy in other infectious and parasitic diseases classified elsewhere (Thoracolumbar region)
0.000 0.989 0.011
M49.34 Spondylopathy in other infectious and parasitic diseases classified elsewhere (Thoracic region)
0.000 0.989 0.011
M49.33 Spondylopathy in other infectious and parasitic diseases classified elsewhere (Cervicothoracic region)
0.000 0.989 0.011

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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