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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs2254556
log Bayes Factor = 51.3587
Chromosome 6   position 31,342,631  (GRCh37) Explore rs2254556 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E10.9 Without complications
0.000 0.000 1.000
K90.0 Coeliac disease
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
G35 Multiple sclerosis
1.000 0.000 0.000
E10-E14 Diabetes mellitus
0.000 0.000 1.000
E00-E07 Disorders of thyroid gland
0.000 0.000 1.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.000 1.000
E03.9 Hypothyroidism, unspecified
0.000 0.000 1.000
E83.1 Disorders of iron metabolism
1.000 0.000 0.000
M06.9 Rheumatoid arthritis, unspecified
0.000 0.000 1.000
E78.0 Pure hypercholesterolaemia
0.000 0.000 1.000
E03 Other hypothyroidism
0.000 0.000 1.000
E10.3 With ophthalmic complications
0.000 0.000 1.000
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.000 0.001 0.999
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.002 0.998
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)
0.000 0.002 0.998
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)
0.000 0.002 0.998
E14 Unspecified diabetes mellitus
0.000 0.004 0.996
E11 Non-insulin-dependent diabetes mellitus
0.000 0.004 0.996
E05.9 Thyrotoxicosis, unspecified
0.000 0.005 0.995
E70-E90 Metabolic disorders
0.000 0.005 0.995
E14.9 Without complications
0.000 0.012 0.988
E10.1 With ketoacidosis
0.000 0.012 0.988
E11.9 Without complications
0.000 0.017 0.983
M06.94 Rheumatoid arthritis, unspecified (Hand)
0.000 0.025 0.975
K51 Ulcerative colitis
0.968 0.032 0.000
K51.9 Ulcerative colitis, unspecified
0.965 0.035 0.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.039 0.961
K51.3 Ulcerative (chronic) rectosigmoiditis
0.948 0.052 0.000
E10.4 With neurological complications
0.000 0.057 0.943
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.064 0.936
E16 Other disorders of pancreatic internal secretion
0.000 0.068 0.932
M06.96 Rheumatoid arthritis, unspecified (Lower leg)
0.000 0.071 0.929
E11.1 With ketoacidosis
0.000 0.072 0.928
K51.4 Pseudopolyposis of colon
0.922 0.078 0.000
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.000 0.078 0.922
I10 Essential (primary) hypertension
0.000 0.086 0.914
K51.8 Other ulcerative colitis
0.905 0.095 0.000
E16.2 Hypoglycaemia, unspecified
0.000 0.101 0.899
E11.0 With coma
0.000 0.105 0.895
M06.92 Rheumatoid arthritis, unspecified (Upper arm)
0.000 0.107 0.893
E78.8 Other disorders of lipoprotein metabolism
0.000 0.109 0.891
E14.3 With ophthalmic complications
0.000 0.109 0.891
G35-G37 Demyelinating diseases of the central nervous system
0.885 0.115 0.000
E07 Other disorders of thyroid
0.000 0.127 0.873
M06.91 Rheumatoid arthritis, unspecified (Shoulder region)
0.000 0.128 0.872
E10.8 With unspecified complications
0.000 0.141 0.859
G37 Other demyelinating diseases of central nervous system
0.846 0.154 0.000
K51.2 Ulcerative (chronic) proctitis
0.845 0.155 0.000
E74 Other disorders of carbohydrate metabolism
0.000 0.155 0.845
E10.2 With renal complications
0.000 0.159 0.841
E85 Amyloidosis
0.000 0.165 0.835
M06.93 Rheumatoid arthritis, unspecified (Forearm)
0.000 0.166 0.834
K51.0 Ulcerative (chronic) enterocolitis
0.831 0.169 0.000
G37.9 Demyelinating disease of central nervous system, unspecified
0.816 0.184 0.000
E78.1 Pure hyperglyceridaemia
0.000 0.187 0.813
E78.5 Hyperlipidaemia, unspecified
0.000 0.194 0.806
E78.2 Mixed hyperlipidaemia
0.000 0.195 0.805
E07.9 Disorder of thyroid, unspecified
0.000 0.198 0.802
E20-E35 Disorders of other endocrine glands
0.000 0.198 0.802
K51.5 Mucosal proctocolitis
0.801 0.199 0.000
E16.1 Other hypoglycaemia
0.000 0.222 0.778
E10.0 With coma
0.000 0.234 0.766
M06.97 Rheumatoid arthritis, unspecified (Ankle and foot)
0.000 0.238 0.762
E10.6 With other specified complications
0.000 0.238 0.762
E14.4 With neurological complications
0.000 0.247 0.753
E11.2 With renal complications
0.000 0.250 0.750
E10.5 With peripheral circulatory complications
0.000 0.250 0.750
E05.8 Other thyrotoxicosis
0.000 0.259 0.741
E74.3 Other disorders of intestinal carbohydrate absorption
0.000 0.263 0.737
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.270 0.729
M06.98 Rheumatoid arthritis, unspecified (Other)
0.000 0.272 0.727
E11.3 With ophthalmic complications
0.000 0.278 0.722
E14.5 With peripheral circulatory complications
0.000 0.283 0.717
E10.7 With multiple complications
0.000 0.283 0.717
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.283 0.717
E00 Congenital iodine-deficiency syndrome
0.000 0.283 0.717
E12 Malnutrition-related diabetes mellitus
0.000 0.283 0.717
E03.5 Myxoedema coma
0.000 0.283 0.717
E03.4 Atrophy of thyroid (acquired)
0.000 0.283 0.717
E03.3 Postinfectious hypothyroidism
0.000 0.283 0.717
E03.1 Congenital hypothyroidism without goitre
0.000 0.283 0.717
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.283 0.717
E78.6 Lipoprotein deficiency
0.000 0.284 0.716
E78.3 Hyperchylomicronaemia
0.000 0.284 0.716
E05.5 Thyroid crisis or storm
0.000 0.284 0.716
E05.4 Thyrotoxicosis factitia
0.000 0.284 0.716
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.284 0.716
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.284 0.716
E14.8 With unspecified complications
0.000 0.286 0.714
E14.7 With multiple complications
0.000 0.286 0.714
E14.6 With other specified complications
0.000 0.286 0.714
E14.2 Withrenal complications
0.000 0.286 0.714
E14.1 With ketoacidosis
0.000 0.286 0.714
E14.0 With coma
0.000 0.286 0.714
E11.7 With multiple complications
0.000 0.286 0.714
E77 Disorders of glycoprotein metabolism
0.000 0.286 0.713
E76 Disorders of glycosaminoglycan metabolism
0.000 0.286 0.713
E72 Other disorders of amino-acid metabolism
0.000 0.286 0.713
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.000 0.286 0.713
E70 Disorders of aromatic amino-acid metabolism
0.000 0.286 0.713
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.000 0.286 0.713
E28 Ovarian dysfunction
0.000 0.294 0.706
E84 Cystic fibrosis
0.000 0.296 0.703
E79 Disorders of purine and pyrimidine metabolism
0.000 0.297 0.703
E13 Other specified diabetes mellitus
0.000 0.299 0.701
E11.5 With peripheral circulatory complications
0.000 0.299 0.701
E78.4 Other hyperlipidaemia
0.000 0.299 0.701
E85.9 Amyloidosis, unspecified
0.000 0.303 0.697
E15 Nondiabetic hypoglycaemic coma
0.000 0.311 0.689
G37.8 Other specified demyelinating diseases of central nervous system
0.688 0.312 0.000
E06 Thyroiditis
0.000 0.315 0.685
E23 Hypofunction and other disorders of pituitary gland
0.000 0.317 0.683
E03.8 Other specified hypothyroidism
0.000 0.317 0.683
E40-E46 Malnutrition
0.000 0.319 0.680
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.000 0.325 0.675
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.331 0.668
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.331 0.668
E16.4 Abnormal secretion of gastrin
0.000 0.331 0.668
E16.3 Increased secretion of glucagon
0.000 0.331 0.668
M45.X9 Ankylosing spondylitis (Site unspecified)
0.000 0.333 0.667
J45.9 Asthma, unspecified
0.000 0.337 0.663
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.339 0.661
E11.8 With unspecified complications
0.000 0.339 0.660
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.341 0.659
E85.4 Organ-limited amyloidosis
0.000 0.341 0.658
E28.2 Polycystic ovarian syndrome
0.000 0.344 0.656
E73 Lactose intolerance
0.000 0.346 0.654
K51.1 Ulcerative (chronic) ileocolitis
0.652 0.347 0.000
I10-I15 Hypertensive diseases
0.000 0.352 0.648
E29 Testicular dysfunction
0.000 0.362 0.638
E11.6 With other specified complications
0.000 0.364 0.636
G36 Other acute disseminated demyelination
0.634 0.365 0.000
E24 Cushing's syndrome
0.000 0.372 0.628
E07.1 Dyshormogenetic goitre
0.000 0.374 0.626
E07.0 Hypersecretion of calcitonin
0.000 0.374 0.626
G37.5 Concentric sclerosis [Balo]
0.607 0.393 0.000
G37.4 Subacute necrotising myelitis
0.607 0.393 0.000
G37.2 Central pontine myelinolysis
0.607 0.393 0.000
G37.1 Central demyelination of corpus callosum
0.607 0.393 0.000
G37.0 Diffuse sclerosis
0.607 0.393 0.000
E74.9 Disorder of carbohydrate metabolism, unspecified
0.000 0.394 0.606
E74.8 Other specified disorders of carbohydrate metabolism
0.000 0.394 0.606
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
0.000 0.394 0.606
E74.2 Disorders of galactose metabolism
0.000 0.394 0.606
E74.1 Disorders of fructose metabolism
0.000 0.394 0.606
E74.0 Glycogen storage disease
0.000 0.394 0.606
M06 Other rheumatoid arthritis
0.000 0.399 0.601
E85.8 Other amyloidosis
0.000 0.402 0.598
E85.2 Heredofamilial amyloidosis, unspecified
0.000 0.402 0.598
E85.1 Neuropathic heredofamilial amyloidosis
0.000 0.402 0.598
E85.0 Nonneuropathic heredofamilial amyloidosis
0.000 0.402 0.598
E22 Hyperfunction of pituitary gland
0.000 0.414 0.586
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.000 0.414 0.586
E23.7 Disorder of pituitary gland, unspecified
0.000 0.418 0.582
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.425 0.575
E32 Diseases of thymus
0.000 0.425 0.575
E31 Polyglandular dysfunction
0.000 0.425 0.575
E30 Disorders of puberty, not elsewhere classified
0.000 0.425 0.575
E25 Adrenogenital disorders
0.000 0.425 0.575
I12 Hypertensive renal disease
0.000 0.430 0.570
E85.3 Secondary systemic amyloidosis
0.000 0.430 0.570
E50-E64 Other nutritional deficiencies
0.000 0.433 0.567
E26 Hyperaldosteronism
0.000 0.434 0.566
E83 Disorders of mineral metabolism
0.313 0.435 0.252
E07.8 Other specified disorders of thyroid
0.000 0.442 0.557
M06.3 Rheumatoid nodule
0.000 0.442 0.558
E78.9 Disorder of lipoprotein metabolism, unspecified
0.000 0.447 0.553
M45 Ankylosing spondylitis
0.000 0.452 0.548
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.000 0.462 0.538
E23.6 Other disorders of pituitary gland
0.000 0.478 0.522
E29.1 Testicular hypofunction
0.000 0.480 0.520
E23.2 Diabetes insipidus
0.000 0.483 0.517
I12.9 Hypertensive renal disease without renal failure
0.000 0.483 0.517
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.000 0.486 0.514
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.000 0.486 0.514
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.000 0.486 0.514
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.000 0.486 0.514
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.486 0.514
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.000 0.486 0.514
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.000 0.486 0.514
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.000 0.486 0.514
E12.9 Without complications
0.000 0.486 0.514
E12.8 With unspecified complications
0.000 0.486 0.514
E12.7 With multiple complications
0.000 0.486 0.514
E12.6 With other specified complications
0.000 0.486 0.514
E12.5 With peripheral circulatory complications
0.000 0.486 0.514
E12.4 With neurological complications
0.000 0.486 0.514
E12.3 With ophthalmic complications
0.000 0.486 0.514
E12.2 With renal complications
0.000 0.486 0.514
E12.1 With ketoacidosis
0.000 0.486 0.514
E12.0 With coma
0.000 0.486 0.514
G37.3 Acute transverse myelitis in demyelinating disease of central nervous system
0.513 0.487 0.000
E70.9 Disorder of aromatic amino-acid metabolism, unspecified
0.000 0.488 0.512
E70.8 Other disorders of aromatic amino-acid metabolism
0.000 0.488 0.512
E70.3 Albinism
0.000 0.488 0.512
E70.2 Disorders of tyrosine metabolism
0.000 0.488 0.512
E70.1 Other hyperphenylalaninaemias
0.000 0.488 0.512
E70.0 Classical phenylketonuria
0.000 0.488 0.512
E71.3 Disorders of fatty-acid metabolism
0.000 0.488 0.512
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified
0.000 0.488 0.512
E71.1 Other disorders of branched-chain amino-acid metabolism
0.000 0.488 0.512
E71.0 Maple-syrup-urine disease
0.000 0.488 0.512
E72.9 Disorder of amino-acid metabolism, unspecified
0.000 0.488 0.512
E72.8 Other specified disorders of amino-acid metabolism
0.000 0.488 0.512
E72.5 Disorders of glycine metabolism
0.000 0.488 0.512
E72.4 Disorders of ornithine metabolism
0.000 0.488 0.512
E72.3 Disorders of lysine and hydroxylysine metabolism
0.000 0.488 0.512
E72.2 Disorders of urea cycle metabolism
0.000 0.488 0.512
E72.1 Disorders of sulphur-bearing amino-acid metabolism
0.000 0.488 0.512
E72.0 Disorders of amino-acid transport
0.000 0.488 0.512
E76.9 Disorder of glucosaminoglycan metabolism, unspecified
0.000 0.488 0.512
E76.8 Other disorders of glucosaminoglycan metabolism
0.000 0.488 0.512
E76.3 Mucopolysaccharidosis, unspecified
0.000 0.488 0.512
E76.2 Other mucopolysaccharidoses
0.000 0.488 0.512
E76.1 Mucopolysaccharidosis, type II
0.000 0.488 0.512
E76.0 Mucopolysaccharidosis, type I
0.000 0.488 0.512
E77.9 Disorder of glycoprotein metabolism, unspecified
0.000 0.488 0.512
E77.8 Other disorders of glycoprotein metabolism
0.000 0.488 0.512
E77.1 Defects in glycoprotein degradation
0.000 0.488 0.512
E77.0 Defects in posttranslational modification of lysosomal enzymes
0.000 0.488 0.512
E89.3 Postprocedural hypopituitarism
0.000 0.491 0.509
E80 Disorders of porphyrin and bilirubin metabolism
0.000 0.492 0.508
E28.9 Ovarian dysfunction, unspecified
0.000 0.493 0.506
E28.8 Other ovarian dysfunction
0.000 0.493 0.506
E28.1 Androgen excess
0.000 0.493 0.506
E28.0 Oestrogen excess
0.000 0.493 0.506
E84.8 Cystic fibrosis with other manifestations
0.000 0.495 0.504
E84.1 Cystic fibrosis with intestinal manifestations
0.000 0.495 0.504
E84.0 Cystic fibrosis with pulmonary manifestations
0.000 0.495 0.504
E79.9 Disorder of purine and pyrimidine metabolism, unspecified
0.000 0.496 0.504
E79.8 Other disorders of purine and pyrimidine metabolism
0.000 0.496 0.504
E79.1 Lesch-Nyhan syndrome
0.000 0.496 0.504
E24.9 Cushing's syndrome, unspecified
0.000 0.496 0.504
E13.8 With unspecified complications
0.000 0.497 0.503
E13.7 With multiple complications
0.000 0.497 0.503
E13.6 With other specified complications
0.000 0.497 0.503
E13.5 With peripheral circulatory complications
0.000 0.497 0.503
E13.4 With neurological complications
0.000 0.497 0.503
E13.3 With ophthalmic complications
0.000 0.497 0.503
E13.2 With renal complications
0.000 0.497 0.503
E13.1 With ketoacidosis
0.000 0.497 0.503
E13.0 With coma
0.000 0.497 0.503
M06.34 Rheumatoid nodule (Hand)
0.000 0.499 0.501
M45.X0 Ankylosing spondylitis (Multiple sites in spine)
0.000 0.500 0.500
E84.9 Cystic fibrosis, unspecified
0.000 0.505 0.494
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
0.000 0.507 0.493
E06.5 Other chronic thyroiditis
0.000 0.509 0.491
E06.4 Drug-induced thyroiditis
0.000 0.509 0.491
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.509 0.491
E06.1 Subacute thyroiditis
0.000 0.509 0.491
E06.0 Acute thyroiditis
0.000 0.509 0.491
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.000 0.510 0.490
E23.1 Drug-induced hypopituitarism
0.000 0.510 0.490
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.512 0.488
E45 Retarded development following protein-energy malnutrition
0.000 0.512 0.488
E43 Unspecified severe protein-energy malnutrition
0.000 0.512 0.488
E42 Marasmic kwashiorkor
0.000 0.512 0.488
E41 Nutritional marasmus
0.000 0.512 0.488
E40 Kwashiorkor
0.000 0.512 0.488
E13.9 Without complications
0.000 0.513 0.487
E61 Deficiency of other nutrient elements
0.000 0.514 0.486
E75.6 Lipid storage disorder, unspecified
0.000 0.516 0.484
E75.4 Neuronal ceroid lipofuscinosis
0.000 0.516 0.484
E75.3 Sphingolipidosis, unspecified
0.000 0.516 0.484
E75.2 Other sphingolipidosis
0.000 0.516 0.484
E75.1 Other gangliosidosis
0.000 0.516 0.484
E75.0 GM2 gangliosidosis
0.000 0.516 0.484
E34 Other endocrine disorders
0.000 0.517 0.482
I15 Secondary hypertension
0.000 0.518 0.481
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.520 0.480
E06.3 Autoimmune thyroiditis
0.000 0.523 0.477
E06.9 Thyroiditis, unspecified
0.000 0.526 0.474
E73.8 Other lactose intolerance
0.000 0.531 0.469
E73.1 Secondary lactase deficiency
0.000 0.531 0.469
E73.0 Congenital lactase deficiency
0.000 0.531 0.469
E65-E68 Obesity and other hyperalimentation
0.000 0.534 0.466
I13 Hypertensive heart and renal disease
0.000 0.535 0.465
M45.X2 Ankylosing spondylitis (Cervical region)
0.000 0.535 0.464
E11.4 With neurological complications
0.000 0.537 0.463
E23.0 Hypopituitarism
0.000 0.541 0.459
E29.9 Testicular dysfunction, unspecified
0.000 0.543 0.457
E29.8 Other testicular dysfunction
0.000 0.543 0.457
E29.0 Testicular hyperfunction
0.000 0.543 0.457
E21.3 Hyperparathyroidism, unspecified
0.000 0.544 0.456
G36.9 Acute disseminated demyelination, unspecified
0.455 0.545 0.000
G36.8 Other specified acute disseminated demyelination
0.455 0.545 0.000
G36.1 Acute and subacute haemorrhagic leukoencephalitis [Hurst]
0.455 0.545 0.000
G36.0 Neuromyelitis optica [Devic]
0.455 0.545 0.000
I11 Hypertensive heart disease
0.000 0.545 0.455
E89.6 Postprocedural adrenocortical(-medullary) hypofunction
0.000 0.548 0.452
E46 Unspecified protein-energy malnutrition
0.000 0.548 0.451
E20 Hypoparathyroidism
0.000 0.549 0.450
E24.8 Other Cushing's syndrome
0.000 0.550 0.450
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.000 0.550 0.450
E24.3 Ectopic ACTH syndrome
0.000 0.550 0.450
E24.2 Drug-induced Cushing's syndrome
0.000 0.550 0.450
E24.1 Nelson's syndrome
0.000 0.550 0.450
E24.0 Pituitary-dependent Cushing's disease
0.000 0.550 0.450
M06.32 Rheumatoid nodule (Upper arm)
0.000 0.552 0.448
E75.5 Other lipid storage disorders
0.000 0.554 0.445
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.000 0.560 0.440
E61.1 Iron deficiency
0.000 0.563 0.437
E22.0 Acromegaly and pituitary gigantism
0.000 0.565 0.434
M06.37 Rheumatoid nodule (Ankle and foot)
0.000 0.566 0.434
E28.3 Primary ovarian failure
0.000 0.567 0.433
M06.8 Other specified rheumatoid arthritis
0.000 0.569 0.431
M06.2 Rheumatoid bursitis
0.000 0.569 0.431
M06.1 Adult-onset Still's disease
0.000 0.569 0.431
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.580 0.420
E22.8 Other hyperfunction of pituitary gland
0.000 0.580 0.420
E89.4 Postprocedural ovarian failure
0.000 0.580 0.420
E89.9 Postprocedural endocrine and metabolic disorder, unspecified
0.000 0.580 0.420
E89.8 Other postprocedural endocrine and metabolic disorders
0.000 0.580 0.420
E89.5 Postprocedural testicular hypofunction
0.000 0.580 0.420
E89.1 Postprocedural hypoinsulinaemia
0.000 0.580 0.420
E25.9 Adrenogenital disorder, unspecified
0.000 0.588 0.412
E25.8 Other adrenogenital disorders
0.000 0.588 0.412
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.000 0.588 0.412
E30.9 Disorder of puberty, unspecified
0.000 0.588 0.412
E30.8 Other disorders of puberty
0.000 0.588 0.412
E30.1 Precocious puberty
0.000 0.588 0.412
E30.0 Delayed puberty
0.000 0.588 0.412
E31.9 Polyglandular dysfunction, unspecified
0.000 0.588 0.412
E31.8 Other polyglandular dysfunction
0.000 0.588 0.412
E31.1 Polyglandular hyperfunction
0.000 0.588 0.412
E31.0 Autoimmune polyglandular failure
0.000 0.588 0.412
E32.9 Disease of thymus, unspecified
0.000 0.588 0.412
E32.8 Other diseases of thymus
0.000 0.588 0.412
E32.1 Abscess of thymus
0.000 0.588 0.412
E32.0 Persistent hyperplasia of thymus
0.000 0.588 0.412
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.588 0.412
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.588 0.412
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.588 0.412
E73.9 Lactose intolerance, unspecified
0.000 0.590 0.409
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.593 0.406
E63 Other nutritional deficiencies
0.000 0.593 0.406
E56 Other vitamin deficiencies
0.000 0.593 0.406
E51 Thiamine deficiency
0.000 0.593 0.406
E50 Vitamin A deficiency
0.000 0.593 0.406
E60 Dietary zinc deficiency
0.000 0.593 0.406
E59 Dietary selenium deficiency
0.000 0.593 0.406
E58 Dietary calcium deficiency
0.000 0.593 0.406
E54 Ascorbic acid deficiency
0.000 0.593 0.406
E52 Niacin deficiency [pellagra]
0.000 0.593 0.406
E26.9 Hyperaldosteronism, unspecified
0.000 0.594 0.406
E26.8 Other hyperaldosteronism
0.000 0.594 0.406
E26.1 Secondary hyperaldosteronism
0.000 0.594 0.406
E83.9 Disorder of mineral metabolism, unspecified
0.224 0.595 0.181
E83.8 Other disorders of mineral metabolism
0.224 0.595 0.181
E83.2 Disorders of zinc metabolism
0.224 0.595 0.181
E83.0 Disorders of copper metabolism
0.224 0.595 0.181
M06.39 Rheumatoid nodule (Site unspecified)
0.000 0.600 0.400
M06.38 Rheumatoid nodule (Other)
0.000 0.600 0.400
M06.36 Rheumatoid nodule (Lower leg)
0.000 0.600 0.400
M06.35 Rheumatoid nodule (Pelvic region and thigh)
0.000 0.600 0.400
M06.33 Rheumatoid nodule (Forearm)
0.000 0.600 0.400
M06.31 Rheumatoid nodule (Shoulder region)
0.000 0.600 0.400
M06.30 Rheumatoid nodule (Multiple sites)
0.000 0.600 0.400
I12.0 Hypertensive renal disease with renal failure
0.000 0.601 0.399
E26.0 Primary hyperaldosteronism
0.000 0.603 0.396
M06.4 Inflammatory polyarthropathy
0.000 0.605 0.395
E22.1 Hyperprolactinaemia
0.000 0.606 0.393
M45.X8 Ankylosing spondylitis (Sacral and sacrococcygeal region)
0.000 0.607 0.393
M45.X7 Ankylosing spondylitis (Lumbosacral region)
0.000 0.607 0.393
M45.X6 Ankylosing spondylitis (Lumbar region)
0.000 0.607 0.393
M45.X5 Ankylosing spondylitis (Thoracolumbar region)
0.000 0.607 0.393
M45.X4 Ankylosing spondylitis (Thoracic region)
0.000 0.607 0.393
M45.X3 Ankylosing spondylitis (Cervicothoracic region)
0.000 0.607 0.393
M45.X1 Ankylosing spondylitis (Occipito-atlanto-axial region)
0.000 0.607 0.393
E21.5 Disorder of parathyroid gland, unspecified
0.000 0.614 0.386
E21.4 Other specified disorders of parathyroid gland
0.000 0.614 0.386
E21.2 Other hyperparathyroidism
0.000 0.614 0.386
E80.7 Disorder of bilirubin metabolism, unspecified
0.000 0.635 0.364
E80.5 Crigler-Najjar syndrome
0.000 0.635 0.364
E80.3 Defects of catalase and peroxydase
0.000 0.635 0.364
E80.2 Other porphyria
0.000 0.635 0.364
E80.0 Hereditary erythropoietic porphyria
0.000 0.635 0.364
I15.1 Hypertension secondary to other renal disorders
0.000 0.638 0.362
E88 Other metabolic disorders
0.001 0.640 0.360
E80.6 Other disorders of bilirubin metabolism
0.000 0.642 0.358
Chapter VI Diseases of the nervous system
0.351 0.649 0.000
E44.1 Mild protein-energy malnutrition
0.000 0.650 0.350
E44.0 Moderate protein-energy malnutrition
0.000 0.650 0.350
E80.1 Porphyria cutanea tarda
0.000 0.651 0.349
E61.9 Deficiency of nutrient element, unspecified
0.000 0.651 0.349
E61.8 Deficiency of other specified nutrient elements
0.000 0.651 0.349
E61.7 Deficiency of multiple nutrient elements
0.000 0.651 0.349
E61.6 Vanadium deficiency
0.000 0.651 0.349
E61.5 Molybdenum deficiency
0.000 0.651 0.349
E61.4 Chromium deficiency
0.000 0.651 0.349
E61.3 Manganese deficiency
0.000 0.651 0.349
E61.0 Copper deficiency
0.000 0.651 0.349
E34.5 Androgen resistance syndrome
0.000 0.654 0.346
E34.4 Constitutional tall stature
0.000 0.654 0.346
E34.3 Short stature, not elsewhere classified
0.000 0.654 0.346
E34.2 Ectopic hormone secretion, not elsewhere classified
0.000 0.654 0.346
E34.1 Other hypersecretion of intestinal hormones
0.000 0.654 0.346
I15.9 Seconday hypertension, unspecified
0.000 0.655 0.345
I15.8 Other secondary hypertension
0.000 0.655 0.345
I15.2 Hypertension secondary to endocrine disorders
0.000 0.655 0.345
I15.0 Renovascular hypertension
0.000 0.655 0.345
E83.3 Disorders of phosphorus metabolism
0.216 0.656 0.128
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.000 0.658 0.342
I11.0 Hypertensive heart disease with (congestive) heart failure
0.000 0.661 0.338
E65 Localised adiposity
0.000 0.665 0.335
E67 Other hyperalimentation
0.000 0.666 0.334
E68 Sequelae of hyperalimentation
0.000 0.666 0.334
I13.9 Hypertensive heart and renal disease, unspecified
0.000 0.667 0.333
I13.2 Hypertensive heart and renal disease with both (congestive) heart failure and renal failure
0.000 0.667 0.333
I13.1 Hypertensive heart and renal disease with renal failure
0.000 0.667 0.333
I13.0 Hypertensive heart and renal disease with (congestive) heart failure
0.000 0.667 0.333
E27 Other disorders of adrenal gland
0.000 0.668 0.332
G30-G32 Other degenerative diseases of the nervous system
0.332 0.668 0.000
G20-G26 Extrapyramidal and movement disorders
0.329 0.671 0.000
E34.8 Other specified endocrine disorders
0.000 0.673 0.326
G20 Parkinson's disease
0.326 0.674 0.000
E34.0 Carcinoid syndrome
0.000 0.676 0.324
E61.2 Magnesium deficiency
0.000 0.676 0.324
E20.8 Other hypoparathyroidism
0.000 0.677 0.323
E20.1 Pseudohypoparathyroidism
0.000 0.677 0.323
E20.0 Idiopathic hypoparathyroidism
0.000 0.677 0.323
G31 Other degenerative diseases of nervous system, not elsewhere classified
0.318 0.681 0.000
G00-G09 Inflammatory diseases of the central nervous system
0.316 0.684 0.000
G31.9 Degenerative disease of nervous system, unspecified
0.316 0.684 0.000
E34.9 Endocrine disorder, unspecified
0.000 0.690 0.310
M06.19 Adult-onset Still's disease (Site unspecified)
0.000 0.691 0.309
M06.18 Adult-onset Still's disease (Other)
0.000 0.691 0.309
M06.17 Adult-onset Still's disease (Ankle and foot)
0.000 0.691 0.309
M06.16 Adult-onset Still's disease (Lower leg)
0.000 0.691 0.309
M06.15 Adult-onset Still's disease (Pelvic region and thigh)
0.000 0.691 0.309
M06.14 Adult-onset Still's disease (Hand)
0.000 0.691 0.309
M06.13 Adult-onset Still's disease (Forearm)
0.000 0.691 0.309
M06.12 Adult-onset Still's disease (Upper arm)
0.000 0.691 0.309
M06.11 Adult-onset Still's disease (Shoulder region)
0.000 0.691 0.309
M06.10 Adult-onset Still's disease (Multiple sites)
0.000 0.691 0.309
M06.29 Rheumatoid bursitis (Site unspecified)
0.000 0.691 0.309
M06.28 Rheumatoid bursitis (Other)
0.000 0.691 0.309
M06.27 Rheumatoid bursitis (Ankle and foot)
0.000 0.691 0.309
M06.26 Rheumatoid bursitis (Lower leg)
0.000 0.691 0.309
M06.25 Rheumatoid bursitis (Pelvic region and thigh)
0.000 0.691 0.309
M06.24 Rheumatoid bursitis (Hand)
0.000 0.691 0.309
M06.23 Rheumatoid bursitis (Forearm)
0.000 0.691 0.309
M06.22 Rheumatoid bursitis (Upper arm)
0.000 0.691 0.309
M06.21 Rheumatoid bursitis (Shoulder region)
0.000 0.691 0.309
M06.20 Rheumatoid bursitis (Multiple sites)
0.000 0.691 0.309
M06.89 Other specified rheumatoid arthritis (Site unspecified)
0.000 0.691 0.309
M06.88 Other specified rheumatoid arthritis (Other)
0.000 0.691 0.309
M06.87 Other specified rheumatoid arthritis (Ankle and foot)
0.000 0.691 0.309
M06.86 Other specified rheumatoid arthritis (Lower leg)
0.000 0.691 0.309
M06.85 Other specified rheumatoid arthritis (Pelvic region and thigh)
0.000 0.691 0.309
M06.84 Other specified rheumatoid arthritis (Hand)
0.000 0.691 0.309
M06.83 Other specified rheumatoid arthritis (Forearm)
0.000 0.691 0.309
M06.82 Other specified rheumatoid arthritis (Upper arm)
0.000 0.691 0.309
M06.81 Other specified rheumatoid arthritis (Shoulder region)
0.000 0.691 0.309
M06.80 Other specified rheumatoid arthritis (Multiple sites)
0.000 0.691 0.309
I11.9 Hypertensive heart disease without (congestive) heart failure
0.000 0.698 0.302
E55 Vitamin D deficiency
0.000 0.706 0.294
E50.9 Vitamin A deficiency, unspecified
0.000 0.708 0.291
E50.8 Other manifestations of vitamin A deficiency
0.000 0.708 0.291
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.708 0.291
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.708 0.291
E50.5 Vitamin A deficiency with night blindness
0.000 0.708 0.291
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.708 0.291
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.708 0.291
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.708 0.291
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.708 0.291
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.708 0.291
E51.9 Thiamine deficiency, unspecified
0.000 0.708 0.291
E51.8 Other manifestations of thiamine deficiency
0.000 0.708 0.291
E51.2 Wernicke's encephalopathy
0.000 0.708 0.291
E51.1 Beriberi
0.000 0.708 0.291
E56.9 Vitamin deficiency, unspecified
0.000 0.708 0.291
E56.8 Deficiency of other vitamins
0.000 0.708 0.291
E56.1 Deficiency of vitamin K
0.000 0.708 0.291
E56.0 Deficiency of vitamin E
0.000 0.708 0.291
E63.9 Nutritional deficiency, unspecified
0.000 0.708 0.291
E63.8 Other specified nutritional deficiencies
0.000 0.708 0.291
E63.1 Imbalance of constituents of food intake
0.000 0.708 0.291
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.708 0.291
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.708 0.291
E64.8 Sequelae of other nutritional deficiencies
0.000 0.708 0.291
E64.3 Sequelae of rickets
0.000 0.708 0.291
E64.2 Sequelae of vitamin C deficiency
0.000 0.708 0.291
E64.1 Sequelae of vitamin A deficiency
0.000 0.708 0.291
E64.0 Sequelae of protein-energy malnutrition
0.000 0.708 0.291
M06.0 Seronegative rheumatoid arthritis
0.000 0.709 0.291
E89.2 Postprocedural hypoparathyroidism
0.000 0.710 0.289
E27.9 Disorder of adrenal gland, unspecified
0.000 0.711 0.289
G80-G83 Cerebral palsy and other paralytic syndromes
0.285 0.715 0.000
M06.48 Inflammatory polyarthropathy (Other)
0.000 0.716 0.283
M06.47 Inflammatory polyarthropathy (Ankle and foot)
0.000 0.716 0.283
M06.46 Inflammatory polyarthropathy (Lower leg)
0.000 0.716 0.283
M06.45 Inflammatory polyarthropathy (Pelvic region and thigh)
0.000 0.716 0.283
M06.44 Inflammatory polyarthropathy (Hand)
0.000 0.716 0.283
M06.43 Inflammatory polyarthropathy (Forearm)
0.000 0.716 0.283
M06.42 Inflammatory polyarthropathy (Upper arm)
0.000 0.716 0.283
M06.41 Inflammatory polyarthropathy (Shoulder region)
0.000 0.716 0.283
E83.4 Disorders of magnesium metabolism
0.078 0.725 0.197
M06.40 Inflammatory polyarthropathy (Multiple sites)
0.000 0.729 0.271

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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