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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs2269423
log Bayes Factor = 135.044
Chromosome 6   position 32,145,707  (GRCh37) Explore rs2269423 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E03.9 Hypothyroidism, unspecified
0.000 0.000 1.000
E10.9 Without complications
0.000 0.000 1.000
K90.0 Coeliac disease
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
G35 Multiple sclerosis
1.000 0.000 0.000
E10-E14 Diabetes mellitus
0.000 0.000 1.000
E00-E07 Disorders of thyroid gland
0.000 0.000 1.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.000 1.000
E03 Other hypothyroidism
0.000 0.000 1.000
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.000 1.000
E11 Non-insulin-dependent diabetes mellitus
0.000 0.000 1.000
E05.9 Thyrotoxicosis, unspecified
0.000 0.000 1.000
E11.9 Without complications
0.000 0.000 1.000
E10.3 With ophthalmic complications
0.000 0.002 0.998
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.003 0.997
E16 Other disorders of pancreatic internal secretion
0.000 0.006 0.994
E20-E35 Disorders of other endocrine glands
0.000 0.007 0.993
G35-G37 Demyelinating diseases of the central nervous system
0.991 0.009 0.000
G37 Other demyelinating diseases of central nervous system
0.989 0.011 0.000
E16.2 Hypoglycaemia, unspecified
0.000 0.014 0.986
E11.1 With ketoacidosis
0.000 0.015 0.985
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.000 0.016 0.984
E14 Unspecified diabetes mellitus
0.000 0.016 0.984
G37.9 Demyelinating disease of central nervous system, unspecified
0.984 0.016 0.000
E21.3 Hyperparathyroidism, unspecified
0.000 0.019 0.981
K51.9 Ulcerative colitis, unspecified
0.977 0.023 0.000
E10.1 With ketoacidosis
0.000 0.023 0.977
K51 Ulcerative colitis
0.963 0.037 0.000
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.040 0.960
J45.9 Asthma, unspecified
0.000 0.040 0.960
K51.3 Ulcerative (chronic) rectosigmoiditis
0.950 0.050 0.000
E14.3 With ophthalmic complications
0.000 0.066 0.934
K51.4 Pseudopolyposis of colon
0.926 0.074 0.000
E11.3 With ophthalmic complications
0.000 0.089 0.911
E13 Other specified diabetes mellitus
0.000 0.100 0.900
E24 Cushing's syndrome
0.000 0.103 0.897
E14.1 With ketoacidosis
0.000 0.114 0.886
E16.1 Other hypoglycaemia
0.000 0.117 0.883
E03.8 Other specified hypothyroidism
0.000 0.121 0.879
G37.8 Other specified demyelinating diseases of central nervous system
0.862 0.138 0.000
K51.5 Mucosal proctocolitis
0.853 0.147 0.000
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.148 0.852
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.152 0.848
E11.2 With renal complications
0.000 0.155 0.845
E13.9 Without complications
0.000 0.157 0.843
E14.4 With neurological complications
0.000 0.161 0.839
E27 Other disorders of adrenal gland
0.000 0.163 0.837
E28 Ovarian dysfunction
0.000 0.167 0.833
E14.9 Without complications
0.000 0.184 0.816
G37.3 Acute transverse myelitis in demyelinating disease of central nervous system
0.816 0.184 0.000
E10.0 With coma
0.000 0.192 0.808
E24.2 Drug-induced Cushing's syndrome
0.000 0.201 0.799
E29 Testicular dysfunction
0.000 0.211 0.789
E10.4 With neurological complications
0.000 0.224 0.776
G36 Other acute disseminated demyelination
0.765 0.234 0.000
E21.5 Disorder of parathyroid gland, unspecified
0.000 0.243 0.757
E10.6 With other specified complications
0.000 0.243 0.757
E14.8 With unspecified complications
0.000 0.246 0.753
E27.3 Drug-induced adrenocortical insufficiency
0.000 0.251 0.749
E27.9 Disorder of adrenal gland, unspecified
0.000 0.257 0.743
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.258 0.742
E05.8 Other thyrotoxicosis
0.000 0.259 0.741
E10.7 With multiple complications
0.000 0.259 0.741
E10.8 With unspecified complications
0.000 0.263 0.737
E24.0 Pituitary-dependent Cushing's disease
0.000 0.263 0.737
E28.2 Polycystic ovarian syndrome
0.000 0.264 0.736
E23 Hypofunction and other disorders of pituitary gland
0.000 0.267 0.733
E21.2 Other hyperparathyroidism
0.000 0.277 0.723
E07 Other disorders of thyroid
0.000 0.278 0.722
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.283 0.717
E00 Congenital iodine-deficiency syndrome
0.000 0.283 0.717
E12 Malnutrition-related diabetes mellitus
0.000 0.283 0.717
E03.5 Myxoedema coma
0.000 0.283 0.717
E03.4 Atrophy of thyroid (acquired)
0.000 0.283 0.717
E03.3 Postinfectious hypothyroidism
0.000 0.283 0.717
E05.5 Thyroid crisis or storm
0.000 0.283 0.717
E05.4 Thyrotoxicosis factitia
0.000 0.283 0.717
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.283 0.717
E11.7 With multiple complications
0.000 0.283 0.717
E15 Nondiabetic hypoglycaemic coma
0.000 0.285 0.715
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.287 0.713
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.287 0.713
E16.4 Abnormal secretion of gastrin
0.000 0.287 0.713
E16.3 Increased secretion of glucagon
0.000 0.287 0.713
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.288 0.712
E32 Diseases of thymus
0.000 0.288 0.712
E30 Disorders of puberty, not elsewhere classified
0.000 0.288 0.712
G37.5 Concentric sclerosis [Balo]
0.709 0.291 0.000
G37.4 Subacute necrotising myelitis
0.709 0.291 0.000
G37.2 Central pontine myelinolysis
0.709 0.291 0.000
G37.1 Central demyelination of corpus callosum
0.709 0.291 0.000
G37.0 Diffuse sclerosis
0.709 0.291 0.000
E21.4 Other specified disorders of parathyroid gland
0.000 0.294 0.706
E14.7 With multiple complications
0.000 0.294 0.705
E14.5 With peripheral circulatory complications
0.000 0.295 0.705
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.000 0.299 0.701
E03.1 Congenital hypothyroidism without goitre
0.000 0.303 0.697
E31 Polyglandular dysfunction
0.000 0.305 0.695
E14.2 Withrenal complications
0.000 0.308 0.691
E10.2 With renal complications
0.000 0.320 0.680
K51.1 Ulcerative (chronic) ileocolitis
0.677 0.322 0.000
E26 Hyperaldosteronism
0.000 0.323 0.677
E40-E46 Malnutrition
0.000 0.333 0.667
E10.5 With peripheral circulatory complications
0.000 0.337 0.663
E24.9 Cushing's syndrome, unspecified
0.000 0.346 0.654
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.350 0.650
E14.0 With coma
0.000 0.351 0.649
E13.8 With unspecified complications
0.000 0.354 0.645
E13.7 With multiple complications
0.000 0.354 0.645
E13.6 With other specified complications
0.000 0.354 0.645
E13.5 With peripheral circulatory complications
0.000 0.354 0.645
E13.4 With neurological complications
0.000 0.354 0.645
E13.2 With renal complications
0.000 0.354 0.645
E13.1 With ketoacidosis
0.000 0.354 0.645
E13.0 With coma
0.000 0.354 0.645
E29.1 Testicular hypofunction
0.000 0.356 0.644
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.000 0.357 0.643
E24.3 Ectopic ACTH syndrome
0.000 0.357 0.643
E24.1 Nelson's syndrome
0.000 0.357 0.643
E11.8 With unspecified complications
0.000 0.362 0.638
E27.8 Other specified disorders of adrenal gland
0.000 0.364 0.636
E11.0 With coma
0.000 0.365 0.634
K51.8 Other ulcerative colitis
0.615 0.385 0.000
E25 Adrenogenital disorders
0.000 0.387 0.613
E23.6 Other disorders of pituitary gland
0.000 0.387 0.613
G36.0 Neuromyelitis optica [Devic]
0.604 0.396 0.000
E24.8 Other Cushing's syndrome
0.000 0.398 0.602
E27.5 Adrenomedullary hyperfunction
0.000 0.400 0.600
E27.0 Other adrenocortical overactivity
0.000 0.400 0.600
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.400 0.599
E28.9 Ovarian dysfunction, unspecified
0.000 0.403 0.597
E28.8 Other ovarian dysfunction
0.000 0.403 0.597
E28.1 Androgen excess
0.000 0.403 0.597
E28.0 Oestrogen excess
0.000 0.403 0.597
E23.7 Disorder of pituitary gland, unspecified
0.000 0.417 0.583
E23.2 Diabetes insipidus
0.000 0.418 0.582
E13.3 With ophthalmic complications
0.000 0.418 0.582
E29.9 Testicular dysfunction, unspecified
0.000 0.434 0.566
E29.8 Other testicular dysfunction
0.000 0.434 0.566
E29.0 Testicular hyperfunction
0.000 0.434 0.566
E20 Hypoparathyroidism
0.000 0.441 0.559
E28.3 Primary ovarian failure
0.000 0.445 0.555
G36.9 Acute disseminated demyelination, unspecified
0.549 0.451 0.000
G36.8 Other specified acute disseminated demyelination
0.549 0.451 0.000
G36.1 Acute and subacute haemorrhagic leukoencephalitis [Hurst]
0.549 0.451 0.000
E83.1 Disorders of iron metabolism
0.538 0.462 0.000
L40.9 Psoriasis, unspecified
0.000 0.463 0.537
E27.2 Addisonian crisis
0.000 0.471 0.529
E07.9 Disorder of thyroid, unspecified
0.000 0.472 0.528
E11.6 With other specified complications
0.000 0.473 0.527
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.000 0.474 0.526
E23.1 Drug-induced hypopituitarism
0.000 0.474 0.526
E34 Other endocrine disorders
0.000 0.481 0.518
E07.1 Dyshormogenetic goitre
0.000 0.482 0.518
E07.0 Hypersecretion of calcitonin
0.000 0.482 0.518
K51.0 Ulcerative (chronic) enterocolitis
0.515 0.485 0.000
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.000 0.486 0.514
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.000 0.486 0.514
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.000 0.486 0.514
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.000 0.486 0.514
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.486 0.514
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.000 0.486 0.514
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.000 0.486 0.514
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.000 0.486 0.514
E12.9 Without complications
0.000 0.486 0.514
E12.8 With unspecified complications
0.000 0.486 0.514
E12.7 With multiple complications
0.000 0.486 0.514
E12.6 With other specified complications
0.000 0.486 0.514
E12.5 With peripheral circulatory complications
0.000 0.486 0.514
E12.4 With neurological complications
0.000 0.486 0.514
E12.3 With ophthalmic complications
0.000 0.486 0.514
E12.2 With renal complications
0.000 0.486 0.514
E12.1 With ketoacidosis
0.000 0.486 0.514
E12.0 With coma
0.000 0.486 0.514
E07.8 Other specified disorders of thyroid
0.000 0.488 0.512
E26.0 Primary hyperaldosteronism
0.000 0.488 0.511
E30.9 Disorder of puberty, unspecified
0.000 0.490 0.510
E30.8 Other disorders of puberty
0.000 0.490 0.510
E30.1 Precocious puberty
0.000 0.490 0.510
E30.0 Delayed puberty
0.000 0.490 0.510
E32.9 Disease of thymus, unspecified
0.000 0.490 0.510
E32.8 Other diseases of thymus
0.000 0.490 0.510
E32.1 Abscess of thymus
0.000 0.490 0.510
E32.0 Persistent hyperplasia of thymus
0.000 0.490 0.510
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.490 0.510
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.490 0.510
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.490 0.510
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.494 0.506
E31.9 Polyglandular dysfunction, unspecified
0.000 0.502 0.498
E31.8 Other polyglandular dysfunction
0.000 0.502 0.498
E31.1 Polyglandular hyperfunction
0.000 0.502 0.498
E26.8 Other hyperaldosteronism
0.000 0.514 0.486
E26.1 Secondary hyperaldosteronism
0.000 0.514 0.486
K90 Intestinal malabsorption
0.000 0.517 0.483
E31.0 Autoimmune polyglandular failure
0.000 0.518 0.482
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.522 0.478
E45 Retarded development following protein-energy malnutrition
0.000 0.522 0.478
E43 Unspecified severe protein-energy malnutrition
0.000 0.522 0.478
E42 Marasmic kwashiorkor
0.000 0.522 0.478
E41 Nutritional marasmus
0.000 0.522 0.478
E40 Kwashiorkor
0.000 0.522 0.478
L40 Psoriasis
0.000 0.524 0.476
E27.4 Other and unspecified adrenocortical insufficiency
0.000 0.526 0.474
E25.9 Adrenogenital disorder, unspecified
0.000 0.560 0.440
E25.8 Other adrenogenital disorders
0.000 0.560 0.440
E14.6 With other specified complications
0.001 0.568 0.431
E46 Unspecified protein-energy malnutrition
0.000 0.572 0.428
L40.5 Arthropathic psoriasis
0.000 0.577 0.423
E06 Thyroiditis
0.000 0.578 0.421
E22 Hyperfunction of pituitary gland
0.000 0.580 0.419
E26.9 Hyperaldosteronism, unspecified
0.000 0.584 0.416
L40.0 Psoriasis vulgaris
0.000 0.585 0.415
K90.9 Intestinal malabsorption, unspecified
0.000 0.589 0.411
E20.1 Pseudohypoparathyroidism
0.000 0.599 0.401
E20.0 Idiopathic hypoparathyroidism
0.000 0.599 0.401
K51.2 Ulcerative (chronic) proctitis
0.387 0.613 0.000
E27.1 Primary adrenocortical insufficiency
0.000 0.616 0.384
L40.1 Generalised pustular psoriasis
0.000 0.618 0.382
E34.8 Other specified endocrine disorders
0.000 0.622 0.377
E34.5 Androgen resistance syndrome
0.000 0.628 0.372
E34.4 Constitutional tall stature
0.000 0.628 0.372
E34.3 Short stature, not elsewhere classified
0.000 0.628 0.372
E34.2 Ectopic hormone secretion, not elsewhere classified
0.000 0.628 0.372
E34.1 Other hypersecretion of intestinal hormones
0.000 0.628 0.372
E11.5 With peripheral circulatory complications
0.000 0.632 0.368
L40.3 Pustulosis palmaris et plantaris
0.000 0.632 0.368
E65-E68 Obesity and other hyperalimentation
0.000 0.638 0.362
E20.8 Other hypoparathyroidism
0.000 0.644 0.356
I10 Essential (primary) hypertension
0.000 0.645 0.355
L40.4 Guttate psoriasis
0.000 0.650 0.350
K90.3 Pancreatic steatorrhoea
0.000 0.653 0.347
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.653 0.347
K90.1 Tropical sprue
0.000 0.653 0.347
E44.1 Mild protein-energy malnutrition
0.000 0.657 0.343
E44.0 Moderate protein-energy malnutrition
0.000 0.657 0.343
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.001 0.658 0.341
L40.2 Acrodermatitis continua
0.000 0.658 0.341
E22.1 Hyperprolactinaemia
0.000 0.668 0.332
E34.0 Carcinoid syndrome
0.000 0.671 0.329
K90.8 Other intestinal malabsorption
0.000 0.676 0.324
E21.0 Primary hyperparathyroidism
0.000 0.678 0.322
E20.9 Hypoparathyroidism, unspecified
0.000 0.682 0.317
L40.8 Other psoriasis
0.000 0.688 0.312
E06.5 Other chronic thyroiditis
0.000 0.693 0.306
E06.4 Drug-induced thyroiditis
0.000 0.697 0.302
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.697 0.302
E06.0 Acute thyroiditis
0.000 0.697 0.302
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.699 0.301
E22.8 Other hyperfunction of pituitary gland
0.000 0.699 0.301
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.000 0.700 0.300
E50-E64 Other nutritional deficiencies
0.000 0.705 0.294
E06.1 Subacute thyroiditis
0.000 0.708 0.292
E83 Disorders of mineral metabolism
0.278 0.721 0.000
E83.3 Disorders of phosphorus metabolism
0.264 0.736 0.000
E67 Other hyperalimentation
0.000 0.740 0.260
E68 Sequelae of hyperalimentation
0.000 0.740 0.260
E34.9 Endocrine disorder, unspecified
0.001 0.755 0.244
E04 Other non-toxic goitre
0.000 0.777 0.223
E83.9 Disorder of mineral metabolism, unspecified
0.221 0.779 0.000
M20.1 Hallux valgus (acquired)
0.219 0.781 0.000
E65 Localised adiposity
0.000 0.782 0.217
E51 Thiamine deficiency
0.000 0.786 0.214
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.789 0.211
E50 Vitamin A deficiency
0.000 0.789 0.211
E60 Dietary zinc deficiency
0.000 0.789 0.211
E59 Dietary selenium deficiency
0.000 0.789 0.211
E54 Ascorbic acid deficiency
0.000 0.789 0.211
E52 Niacin deficiency [pellagra]
0.000 0.789 0.211
E06.9 Thyroiditis, unspecified
0.000 0.789 0.211
E56 Other vitamin deficiencies
0.000 0.793 0.207
E83.8 Other disorders of mineral metabolism
0.200 0.800 0.000
E83.2 Disorders of zinc metabolism
0.200 0.800 0.000
E83.0 Disorders of copper metabolism
0.200 0.800 0.000
E63 Other nutritional deficiencies
0.000 0.800 0.199
E06.3 Autoimmune thyroiditis
0.000 0.803 0.197
E58 Dietary calcium deficiency
0.000 0.809 0.191
E11.4 With neurological complications
0.000 0.813 0.187
E67.8 Other specified hyperalimentation
0.000 0.814 0.186
E67.3 Hypervitaminosis D
0.000 0.814 0.186
E67.2 Megavitamin-B6 syndrome
0.000 0.814 0.186
E67.1 Hypercarotenaemia
0.000 0.814 0.186
E67.0 Hypervitaminosis A
0.000 0.814 0.186
Z93.2 Ileostomy status
0.180 0.820 0.000
E53 Deficiency of other B group vitamins
0.000 0.826 0.173
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.000 0.833 0.167
E61 Deficiency of other nutrient elements
0.000 0.835 0.165
E04.0 Non-toxic diffuse goitre
0.000 0.837 0.162
E04.8 Other specified non-toxic goitre
0.000 0.840 0.160
E22.0 Acromegaly and pituitary gigantism
0.001 0.843 0.156
E51.2 Wernicke's encephalopathy
0.000 0.843 0.156
E51.9 Thiamine deficiency, unspecified
0.000 0.846 0.154
E51.8 Other manifestations of thiamine deficiency
0.000 0.846 0.154
E51.1 Beriberi
0.000 0.846 0.154
E50.9 Vitamin A deficiency, unspecified
0.000 0.848 0.151
E50.8 Other manifestations of vitamin A deficiency
0.000 0.848 0.151
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.848 0.151
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.848 0.151
E50.5 Vitamin A deficiency with night blindness
0.000 0.848 0.151
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.848 0.151
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.848 0.151
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.848 0.151
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.848 0.151
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.848 0.151
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.848 0.151
E64.8 Sequelae of other nutritional deficiencies
0.000 0.848 0.151
E64.3 Sequelae of rickets
0.000 0.848 0.151
E64.2 Sequelae of vitamin C deficiency
0.000 0.848 0.151
E64.1 Sequelae of vitamin A deficiency
0.000 0.848 0.151
E64.0 Sequelae of protein-energy malnutrition
0.000 0.848 0.151
E56.9 Vitamin deficiency, unspecified
0.000 0.851 0.149
E56.8 Deficiency of other vitamins
0.000 0.851 0.149
E56.0 Deficiency of vitamin E
0.000 0.851 0.149
E83.4 Disorders of magnesium metabolism
0.147 0.853 0.000
E56.1 Deficiency of vitamin K
0.000 0.855 0.145
E63.8 Other specified nutritional deficiencies
0.000 0.857 0.143
E63.1 Imbalance of constituents of food intake
0.000 0.857 0.143
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.857 0.143
D68 Other coagulation defects
0.139 0.861 0.000
E55 Vitamin D deficiency
0.000 0.863 0.137
D68.9 Coagulation defect, unspecified
0.135 0.865 0.000
J45 Asthma
0.000 0.866 0.134
D68.3 Haemorrhagic disorder due to circulating anticoagulants
0.132 0.868 0.000
E63.9 Nutritional deficiency, unspecified
0.000 0.868 0.131
D68.5 Primary Thrombophilia
0.132 0.868 0.000
D68.1 Hereditary factor XI deficiency
0.131 0.869 0.000
I10-I15 Hypertensive diseases
0.000 0.869 0.131
E04.1 Non-toxic single thyroid nodule
0.000 0.874 0.126
E53.8 Deficiency of other specified B group vitamins
0.000 0.874 0.126
E53.1 Pyridoxine deficiency
0.000 0.875 0.124
E53.0 Riboflavin deficiency
0.000 0.875 0.124
E23.0 Hypopituitarism
0.001 0.875 0.124
E61.9 Deficiency of nutrient element, unspecified
0.000 0.881 0.119
E61.8 Deficiency of other specified nutrient elements
0.000 0.881 0.119
E61.7 Deficiency of multiple nutrient elements
0.000 0.881 0.119
E61.6 Vanadium deficiency
0.000 0.881 0.119
E61.5 Molybdenum deficiency
0.000 0.881 0.119
E61.4 Chromium deficiency
0.000 0.881 0.119
E61.3 Manganese deficiency
0.000 0.881 0.119
E61.0 Copper deficiency
0.000 0.881 0.119
I15 Secondary hypertension
0.000 0.881 0.119
K50-K52 Noninfective enteritis and colitis
0.110 0.890 0.000
D68.0 Von Willebrand's disease
0.107 0.893 0.000
I15.9 Seconday hypertension, unspecified
0.000 0.897 0.103
D68.8 Other specified coagulation defects
0.101 0.899 0.000
E04.9 Non-toxic goitre, unspecified
0.000 0.899 0.101
E61.2 Magnesium deficiency
0.000 0.900 0.100
L40-L45 Papulosquamous disorders
0.000 0.901 0.099
E61.1 Iron deficiency
0.000 0.901 0.099
E55.0 Rickets, active
0.000 0.901 0.098
D68.2 Hereditary deficiency of other clotting factors
0.098 0.902 0.000
J45.1 Nonallergic asthma
0.000 0.904 0.096
D68.4 Acquired coagulation factor deficiency
0.096 0.904 0.000
I15.1 Hypertension secondary to other renal disorders
0.000 0.906 0.094
I15.0 Renovascular hypertension
0.000 0.908 0.092
I15.8 Other secondary hypertension
0.000 0.915 0.085
I15.2 Hypertension secondary to endocrine disorders
0.000 0.915 0.085
E53.9 Vitamin B deficiency, unspecified
0.001 0.915 0.085
D68.6 Other Thrombophilia
0.084 0.916 0.000
I13 Hypertensive heart and renal disease
0.000 0.916 0.084
J45.8 Mixed asthma
0.000 0.922 0.077
I11 Hypertensive heart disease
0.000 0.926 0.074
L44 Other papulosquamous disorders
0.000 0.928 0.071
L41 Parapsoriasis
0.000 0.928 0.071
L45 Papulosquamous disorders in diseases classified elsewhere
0.000 0.928 0.071
I12 Hypertensive renal disease
0.000 0.935 0.065
M45.X9 Ankylosing spondylitis (Site unspecified)
0.064 0.936 0.000
I13.9 Hypertensive heart and renal disease, unspecified
0.000 0.939 0.060
I13.1 Hypertensive heart and renal disease with renal failure
0.000 0.939 0.060
I13.0 Hypertensive heart and renal disease with (congestive) heart failure
0.000 0.939 0.060
L42 Pityriasis rosea
0.000 0.941 0.059
K50 Crohn's disease [regional enteritis]
0.058 0.942 0.000
K50.1 Crohn's disease of large intestine
0.053 0.947 0.000
L41.9 Parapsoriasis, unspecified
0.000 0.948 0.051
L41.8 Other parapsoriasis
0.000 0.948 0.051
L41.5 Retiform parapsoriasis
0.000 0.948 0.051
L41.4 Large plaque parapsoriasis
0.000 0.948 0.051
L41.3 Small plaque parapsoriasis
0.000 0.948 0.051
L41.2 Lymphomatoid papulosis
0.000 0.948 0.051
L41.1 Pityriasis lichenoides chronica
0.000 0.948 0.051
L41.0 Pityriasis lichenoides et varioliformis acuta
0.000 0.948 0.051
L44.9 Papulosquamous disorder, unspecified
0.000 0.948 0.051
L44.8 Other specified papulosquamous disorders
0.000 0.948 0.051
L44.4 Infantile papular acrodermatitis [Giannotti-Crosti]
0.000 0.948 0.051
L44.3 Lichen ruber moniliformis
0.000 0.948 0.051
L44.2 Lichen striatus
0.000 0.948 0.051
L44.1 Lichen nitidus
0.000 0.948 0.051
L44.0 Pityriasis rubra pilaris
0.000 0.948 0.051
I13.2 Hypertensive heart and renal disease with both (congestive) heart failure and renal failure
0.000 0.949 0.050
E83.5 Disorders of calcium metabolism
0.050 0.950 0.000
I11.0 Hypertensive heart disease with (congestive) heart failure
0.000 0.950 0.050
L43 Lichen planus
0.000 0.954 0.046
D64.9 Anaemia, unspecified
0.000 0.955 0.045
A04.7 Enterocolitis due to Clostridium difficile
0.043 0.957 0.000
K50.8 Other Crohn's disease
0.041 0.959 0.000
I12.9 Hypertensive renal disease without renal failure
0.000 0.961 0.039
I11.9 Hypertensive heart disease without (congestive) heart failure
0.000 0.962 0.038
E66 Obesity
0.000 0.962 0.038
K90-K93 Other diseases of the digestive system
0.000 0.963 0.037
M45 Ankylosing spondylitis
0.037 0.963 0.000
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions
0.036 0.964 0.000
L43.3 Subacute (active) lichen planus
0.000 0.967 0.033
L43.2 Lichenoid drug reaction
0.000 0.967 0.033
L43.1 Bullous lichen planus
0.000 0.967 0.033
L43.0 Hypertrophic lichen planus
0.000 0.967 0.033
I12.0 Hypertensive renal disease with renal failure
0.000 0.968 0.032
M45.X0 Ankylosing spondylitis (Multiple sites in spine)
0.032 0.968 0.000
D66 Hereditary factor VIII deficiency
0.029 0.971 0.000
M45.X2 Ankylosing spondylitis (Cervical region)
0.028 0.972 0.000
E04.2 Non-toxic multinodular goitre
0.000 0.973 0.027
E66.1 Drug-induced obesity
0.000 0.973 0.027
L43.8 Other lichen planus
0.000 0.973 0.027
K93 Disorders of other digestive organs in diseases classified elsewhere
0.000 0.973 0.027
M45.X8 Ankylosing spondylitis (Sacral and sacrococcygeal region)
0.027 0.973 0.000
M45.X7 Ankylosing spondylitis (Lumbosacral region)
0.027 0.973 0.000
M45.X5 Ankylosing spondylitis (Thoracolumbar region)
0.027 0.973 0.000
M45.X4 Ankylosing spondylitis (Thoracic region)
0.027 0.973 0.000
M45.X3 Ankylosing spondylitis (Cervicothoracic region)
0.027 0.973 0.000
M45.X1 Ankylosing spondylitis (Occipito-atlanto-axial region)
0.027 0.973 0.000
D67 Hereditary factor IX deficiency
0.026 0.974 0.000
M45.X6 Ankylosing spondylitis (Lumbar region)
0.026 0.974 0.000
N83.1 Corpus luteum cyst
0.000 0.974 0.026
Z83.7 Family history of diseases of the digestive system
0.000 0.975 0.025
D65 Disseminated intravascular coagulation [defibrination syndrome]
0.025 0.975 0.000
K58.0 Irritable bowel syndrome with diarrhoea
0.000 0.975 0.025
E55.9 Vitamin D deficiency, unspecified
0.000 0.975 0.024
E66.2 Extreme obesity with alveolar hypoventilation
0.000 0.975 0.024
I65.2 Occlusion and stenosis of carotid artery
0.000 0.977 0.023
K58.9 Irritable bowel syndrome without diarrhoea
0.000 0.978 0.022
M95.0 Acquired deformity of nose
0.022 0.978 0.000
K58 Irritable bowel syndrome
0.000 0.979 0.021
K93.8 Disorders of other specified digestive organs in diseases classified elsewhere
0.000 0.980 0.019
K93.1 Megacolon in Chagas' disease
0.000 0.980 0.019
K93.0 Tuberculous disorders of intestines, peritoneum and mesenteric glands
0.000 0.980 0.019
L43.9 Lichen planus, unspecified
0.000 0.981 0.019
E66.0 Obesity due to excess calories
0.000 0.981 0.019
J45.0 Predominantly allergic asthma
0.000 0.982 0.018
K50.9 Crohn's disease, unspecified
0.017 0.983 0.000
K50.0 Crohn's disease of small intestine
0.016 0.984 0.000
I65 Occlusion and stenosis of precerebral arteries, not resulting in cerebral infarction
0.000 0.985 0.015
I24.9 Acute ischaemic heart disease, unspecified
0.000 0.985 0.015
Y42.7 Androgens and anabolic congeners
0.000 0.985 0.015
D64 Other anaemias
0.000 0.986 0.014
I65.0 Occlusion and stenosis of vertebral artery
0.000 0.986 0.014
E70-E90 Metabolic disorders
0.001 0.987 0.012
I65.3 Occlusion and stenosis of multiple and bilateral precerebral arteries
0.000 0.987 0.012
R06.5 Mouth breathing
0.012 0.988 0.000
N47 Redundant prepuce, phimosis and paraphimosis
0.000 0.988 0.012
I65.9 Occlusion and stenosis of unspecified precerebral artery
0.000 0.989 0.011
I65.8 Occlusion and stenosis of other precerebral artery
0.000 0.989 0.011
L90.0 Lichen sclerosus et atrophicus
0.000 0.989 0.011
I65.1 Occlusion and stenosis of basilar artery
0.000 0.989 0.010
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.000 0.990 0.010
E74 Other disorders of carbohydrate metabolism
0.001 0.990 0.010
D64.4 Congenital dyserythropoietic anaemia
0.000 0.990 0.010
D64.3 Other sideroblastic anaemias
0.000 0.990 0.010
D64.2 Secondary sideroblastic anaemia due to drugs and toxins
0.000 0.990 0.010
D64.1 Secondary sideroblastic anaemia due to disease
0.000 0.990 0.010
J43.9 Emphysema, unspecified
0.000 0.990 0.010
E77 Disorders of glycoprotein metabolism
0.001 0.990 0.009
E76 Disorders of glycosaminoglycan metabolism
0.001 0.990 0.009
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.001 0.990 0.009
E70 Disorders of aromatic amino-acid metabolism
0.001 0.990 0.009
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.001 0.990 0.009
E89.0 Postprocedural hypothyroidism
0.000 0.990 0.010
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.001 0.990 0.008
N48.0 Leukoplakia of penis
0.000 0.991 0.009
E72 Other disorders of amino-acid metabolism
0.001 0.991 0.008
D64.0 Hereditary sideroblastic anaemia
0.000 0.991 0.009
E89.6 Postprocedural adrenocortical(-medullary) hypofunction
0.000 0.991 0.009
J43 Emphysema
0.000 0.991 0.009
Y42 Hormones and their synthetic substitutes and antagonists, not elsewhere classified
0.000 0.991 0.009
E79 Disorders of purine and pyrimidine metabolism
0.001 0.991 0.008
E88 Other metabolic disorders
0.001 0.991 0.008
N48.1 Balanoposthitis
0.000 0.991 0.009
I49.8 Other specified cardiac arrhythmias
0.000 0.991 0.009
Y42.8 Other and unspecified hormones and their synthetic substitutes
0.000 0.991 0.009
E80 Disorders of porphyrin and bilirubin metabolism
0.001 0.991 0.008
E73 Lactose intolerance
0.001 0.991 0.007
N48 Other disorders of penis
0.000 0.992 0.008
D64.8 Other specified anaemias
0.000 0.992 0.008
E74.3 Other disorders of intestinal carbohydrate absorption
0.001 0.992 0.008
E84 Cystic fibrosis
0.001 0.992 0.007
N48.6 Balanitis xerotica obliterans
0.000 0.992 0.008
M79.85 Other specified soft tissue disorders (Pelvic region and thigh)
0.000 0.992 0.008
M95 Other acquired deformities of musculoskeletal system and connective tissue
0.008 0.992 0.000
J40-J47 Chronic lower respiratory diseases
0.000 0.992 0.008
Y42.0 Glucocorticoids and synthetic analogs
0.000 0.992 0.008
N81.5 Vaginal enterocele
0.008 0.992 0.000
S01.5 Open wound of lip and oral cavity
0.008 0.992 0.000
K52 Other non-infective gastro-enteritis and colitis
0.008 0.992 0.000
E89.9 Postprocedural endocrine and metabolic disorder, unspecified
0.000 0.992 0.007
E89.8 Other postprocedural endocrine and metabolic disorders
0.000 0.992 0.007
E89.5 Postprocedural testicular hypofunction
0.000 0.992 0.007
Y42.2 Antithyroid drugs
0.000 0.992 0.008
E74.9 Disorder of carbohydrate metabolism, unspecified
0.001 0.992 0.007
E74.8 Other specified disorders of carbohydrate metabolism
0.001 0.992 0.007
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
0.001 0.992 0.007
E74.2 Disorders of galactose metabolism
0.001 0.992 0.007
E74.1 Disorders of fructose metabolism
0.001 0.992 0.007
E74.0 Glycogen storage disease
0.001 0.992 0.007

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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