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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs2281390
log Bayes Factor = 15.4877
Chromosome 6   position 33,059,669  (GRCh37) Explore rs2281390 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E10.9 Without complications
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
E10.3 With ophthalmic complications
0.000 0.000 1.000
E10-E14 Diabetes mellitus
0.000 0.002 0.998
E16.2 Hypoglycaemia, unspecified
0.000 0.008 0.992
E16 Other disorders of pancreatic internal secretion
0.000 0.010 0.990
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.012 0.988
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.013 0.987
E11 Non-insulin-dependent diabetes mellitus
0.000 0.020 0.980
E10.1 With ketoacidosis
0.000 0.022 0.978
E11.2 With renal complications
0.000 0.056 0.944
E10.4 With neurological complications
0.000 0.076 0.924
E11.3 With ophthalmic complications
0.000 0.080 0.920
E11.1 With ketoacidosis
0.000 0.093 0.907
E10.2 With renal complications
0.000 0.123 0.877
E20-E35 Disorders of other endocrine glands
0.000 0.145 0.855
K90.0 Coeliac disease
0.000 0.154 0.846
E10.5 With peripheral circulatory complications
0.000 0.179 0.821
E11.4 With neurological complications
0.000 0.180 0.820
E27 Other disorders of adrenal gland
0.000 0.198 0.802
E10.8 With unspecified complications
0.000 0.203 0.797
E10.0 With coma
0.000 0.226 0.774
E16.1 Other hypoglycaemia
0.000 0.230 0.770
E34 Other endocrine disorders
0.000 0.241 0.759
E27.1 Primary adrenocortical insufficiency
0.000 0.262 0.738
E70-E90 Metabolic disorders
0.000 0.268 0.732
E22 Hyperfunction of pituitary gland
0.000 0.268 0.732
E20 Hypoparathyroidism
0.000 0.276 0.724
E50-E64 Other nutritional deficiencies
0.000 0.281 0.719
E83 Disorders of mineral metabolism
0.000 0.282 0.718
E83.1 Disorders of iron metabolism
0.000 0.282 0.718
E10.7 With multiple complications
0.000 0.283 0.717
E10.6 With other specified complications
0.000 0.283 0.717
E12 Malnutrition-related diabetes mellitus
0.000 0.285 0.715
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.290 0.710
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.290 0.710
E16.4 Abnormal secretion of gastrin
0.000 0.290 0.710
E16.3 Increased secretion of glucagon
0.000 0.290 0.710
E15 Nondiabetic hypoglycaemic coma
0.000 0.292 0.708
E11.7 With multiple complications
0.000 0.297 0.703
E11.0 With coma
0.000 0.315 0.685
E11.6 With other specified complications
0.000 0.329 0.671
E34.9 Endocrine disorder, unspecified
0.000 0.334 0.666
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.348 0.652
E27.9 Disorder of adrenal gland, unspecified
0.000 0.367 0.633
E20.9 Hypoparathyroidism, unspecified
0.000 0.370 0.629
E27.8 Other specified disorders of adrenal gland
0.000 0.378 0.622
E27.4 Other and unspecified adrenocortical insufficiency
0.000 0.380 0.620
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.000 0.387 0.613
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.387 0.613
E32 Diseases of thymus
0.000 0.387 0.613
E31 Polyglandular dysfunction
0.000 0.387 0.613
E30 Disorders of puberty, not elsewhere classified
0.000 0.387 0.613
E22.0 Acromegaly and pituitary gigantism
0.000 0.395 0.605
E14 Unspecified diabetes mellitus
0.000 0.398 0.602
E26 Hyperaldosteronism
0.000 0.399 0.601
E53 Deficiency of other B group vitamins
0.000 0.400 0.600
E34.0 Carcinoid syndrome
0.000 0.402 0.597
E11.8 With unspecified complications
0.000 0.420 0.580
E27.5 Adrenomedullary hyperfunction
0.000 0.425 0.575
E27.0 Other adrenocortical overactivity
0.000 0.425 0.575
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.000 0.432 0.568
E25 Adrenogenital disorders
0.000 0.445 0.555
E34.8 Other specified endocrine disorders
0.000 0.451 0.549
E22.1 Hyperprolactinaemia
0.000 0.452 0.548
E83.4 Disorders of magnesium metabolism
0.000 0.453 0.547
E27.2 Addisonian crisis
0.000 0.455 0.545
E34.5 Androgen resistance syndrome
0.000 0.456 0.544
E34.4 Constitutional tall stature
0.000 0.456 0.544
E34.3 Short stature, not elsewhere classified
0.000 0.456 0.544
E34.2 Ectopic hormone secretion, not elsewhere classified
0.000 0.456 0.544
E34.1 Other hypersecretion of intestinal hormones
0.000 0.456 0.544
E27.3 Drug-induced adrenocortical insufficiency
0.000 0.457 0.543
E53.8 Deficiency of other specified B group vitamins
0.000 0.467 0.533
E28 Ovarian dysfunction
0.000 0.468 0.532
E87 Other disorders of fluid, electrolyte and acid-base balance
0.000 0.474 0.526
E84 Cystic fibrosis
0.000 0.475 0.525
E79 Disorders of purine and pyrimidine metabolism
0.000 0.475 0.525
E77 Disorders of glycoprotein metabolism
0.000 0.475 0.525
E76 Disorders of glycosaminoglycan metabolism
0.000 0.475 0.525
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.000 0.475 0.525
E72 Other disorders of amino-acid metabolism
0.000 0.475 0.525
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.000 0.475 0.525
E70 Disorders of aromatic amino-acid metabolism
0.000 0.475 0.525
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.000 0.475 0.525
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.475 0.525
E22.8 Other hyperfunction of pituitary gland
0.000 0.475 0.525
E40-E46 Malnutrition
0.001 0.481 0.519
E20.8 Other hypoparathyroidism
0.000 0.481 0.519
E20.1 Pseudohypoparathyroidism
0.000 0.481 0.519
E20.0 Idiopathic hypoparathyroidism
0.000 0.481 0.519
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.485 0.515
E63 Other nutritional deficiencies
0.000 0.485 0.515
E56 Other vitamin deficiencies
0.000 0.485 0.515
E51 Thiamine deficiency
0.000 0.485 0.515
E50 Vitamin A deficiency
0.000 0.485 0.515
E60 Dietary zinc deficiency
0.000 0.485 0.515
E59 Dietary selenium deficiency
0.000 0.485 0.515
E58 Dietary calcium deficiency
0.000 0.485 0.515
E54 Ascorbic acid deficiency
0.000 0.485 0.515
E52 Niacin deficiency [pellagra]
0.000 0.485 0.515
E83.9 Disorder of mineral metabolism, unspecified
0.000 0.485 0.515
E83.8 Other disorders of mineral metabolism
0.000 0.485 0.515
E83.2 Disorders of zinc metabolism
0.000 0.485 0.515
E83.0 Disorders of copper metabolism
0.000 0.485 0.515
E89.3 Postprocedural hypopituitarism
0.000 0.485 0.515
E12.9 Without complications
0.000 0.487 0.513
E12.8 With unspecified complications
0.000 0.487 0.513
E12.7 With multiple complications
0.000 0.487 0.513
E12.6 With other specified complications
0.000 0.487 0.513
E12.5 With peripheral circulatory complications
0.000 0.487 0.513
E12.4 With neurological complications
0.000 0.487 0.513
E12.3 With ophthalmic complications
0.000 0.487 0.513
E12.2 With renal complications
0.000 0.487 0.513
E12.1 With ketoacidosis
0.000 0.487 0.513
E12.0 With coma
0.000 0.487 0.513
E13 Other specified diabetes mellitus
0.001 0.488 0.511
E85 Amyloidosis
0.000 0.490 0.510
E29 Testicular dysfunction
0.000 0.492 0.508
E74 Other disorders of carbohydrate metabolism
0.000 0.494 0.506
E87.5 Hyperkalaemia
0.000 0.502 0.498
E89.2 Postprocedural hypoparathyroidism
0.000 0.509 0.491
E55 Vitamin D deficiency
0.000 0.510 0.490
E11.5 With peripheral circulatory complications
0.000 0.515 0.485
E26.0 Primary hyperaldosteronism
0.000 0.523 0.477
E80 Disorders of porphyrin and bilirubin metabolism
0.000 0.526 0.474
E23 Hypofunction and other disorders of pituitary gland
0.000 0.535 0.465
E87.8 Other disorders of electrolyte and fluid balance, not elsewhere classified
0.000 0.536 0.464
E89.6 Postprocedural adrenocortical(-medullary) hypofunction
0.000 0.539 0.461
E14.4 With neurological complications
0.000 0.550 0.450
K90 Intestinal malabsorption
0.000 0.551 0.449
E89.9 Postprocedural endocrine and metabolic disorder, unspecified
0.000 0.560 0.440
E89.8 Other postprocedural endocrine and metabolic disorders
0.000 0.560 0.440
E89.5 Postprocedural testicular hypofunction
0.000 0.560 0.440
E89.1 Postprocedural hypoinsulinaemia
0.000 0.560 0.440
E30.9 Disorder of puberty, unspecified
0.000 0.560 0.440
E30.8 Other disorders of puberty
0.000 0.560 0.440
E30.1 Precocious puberty
0.000 0.560 0.440
E30.0 Delayed puberty
0.000 0.560 0.440
E31.9 Polyglandular dysfunction, unspecified
0.000 0.560 0.440
E31.8 Other polyglandular dysfunction
0.000 0.560 0.440
E31.1 Polyglandular hyperfunction
0.000 0.560 0.440
E31.0 Autoimmune polyglandular failure
0.000 0.560 0.440
E32.9 Disease of thymus, unspecified
0.000 0.560 0.440
E32.8 Other diseases of thymus
0.000 0.560 0.440
E32.1 Abscess of thymus
0.000 0.560 0.440
E32.0 Persistent hyperplasia of thymus
0.000 0.560 0.440
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.560 0.440
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.560 0.440
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.560 0.440
E73 Lactose intolerance
0.000 0.563 0.437
E14.7 With multiple complications
0.000 0.568 0.432
E14.6 With other specified complications
0.000 0.568 0.432
E14.5 With peripheral circulatory complications
0.000 0.568 0.432
E14.2 Withrenal complications
0.000 0.568 0.432
E14.1 With ketoacidosis
0.000 0.568 0.432
E14.0 With coma
0.000 0.568 0.432
E26.8 Other hyperaldosteronism
0.000 0.569 0.431
E26.1 Secondary hyperaldosteronism
0.000 0.569 0.431
E53.1 Pyridoxine deficiency
0.000 0.570 0.430
E53.0 Riboflavin deficiency
0.000 0.570 0.430
E88 Other metabolic disorders
0.000 0.571 0.429
E61 Deficiency of other nutrient elements
0.000 0.574 0.426
E87.1 Hypo-osmolality and hyponatraemia
0.000 0.586 0.414
E89.4 Postprocedural ovarian failure
0.000 0.588 0.412
E14.3 With ophthalmic complications
0.000 0.591 0.409
E14.8 With unspecified complications
0.000 0.593 0.407
E89.0 Postprocedural hypothyroidism
0.000 0.594 0.406
E25.9 Adrenogenital disorder, unspecified
0.000 0.602 0.398
E25.8 Other adrenogenital disorders
0.000 0.602 0.398
K90.9 Intestinal malabsorption, unspecified
0.000 0.609 0.391
E83.3 Disorders of phosphorus metabolism
0.000 0.610 0.389
E28.3 Primary ovarian failure
0.000 0.616 0.383
E53.9 Vitamin B deficiency, unspecified
0.000 0.617 0.383
E28.9 Ovarian dysfunction, unspecified
0.000 0.619 0.381
E28.8 Other ovarian dysfunction
0.000 0.619 0.381
E28.1 Androgen excess
0.000 0.619 0.381
E28.0 Oestrogen excess
0.000 0.619 0.381
E85.3 Secondary systemic amyloidosis
0.000 0.621 0.378
E87.4 Mixed disorder of acid-base balance
0.000 0.623 0.377
E70.9 Disorder of aromatic amino-acid metabolism, unspecified
0.000 0.623 0.376
E70.8 Other disorders of aromatic amino-acid metabolism
0.000 0.623 0.376
E70.3 Albinism
0.000 0.623 0.376
E70.2 Disorders of tyrosine metabolism
0.000 0.623 0.376
E70.1 Other hyperphenylalaninaemias
0.000 0.623 0.376
E70.0 Classical phenylketonuria
0.000 0.623 0.376
E71.3 Disorders of fatty-acid metabolism
0.000 0.623 0.376
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified
0.000 0.623 0.376
E71.1 Other disorders of branched-chain amino-acid metabolism
0.000 0.623 0.376
E71.0 Maple-syrup-urine disease
0.000 0.623 0.376
E72.9 Disorder of amino-acid metabolism, unspecified
0.000 0.623 0.376
E72.8 Other specified disorders of amino-acid metabolism
0.000 0.623 0.376
E72.5 Disorders of glycine metabolism
0.000 0.623 0.376
E72.4 Disorders of ornithine metabolism
0.000 0.623 0.376
E72.3 Disorders of lysine and hydroxylysine metabolism
0.000 0.623 0.376
E72.2 Disorders of urea cycle metabolism
0.000 0.623 0.376
E72.1 Disorders of sulphur-bearing amino-acid metabolism
0.000 0.623 0.376
E72.0 Disorders of amino-acid transport
0.000 0.623 0.376
E75.6 Lipid storage disorder, unspecified
0.000 0.623 0.376
E75.5 Other lipid storage disorders
0.000 0.623 0.376
E75.4 Neuronal ceroid lipofuscinosis
0.000 0.623 0.376
E75.3 Sphingolipidosis, unspecified
0.000 0.623 0.376
E75.2 Other sphingolipidosis
0.000 0.623 0.376
E75.1 Other gangliosidosis
0.000 0.623 0.376
E75.0 GM2 gangliosidosis
0.000 0.623 0.376
E76.9 Disorder of glucosaminoglycan metabolism, unspecified
0.000 0.623 0.376
E76.8 Other disorders of glucosaminoglycan metabolism
0.000 0.623 0.376
E76.3 Mucopolysaccharidosis, unspecified
0.000 0.623 0.376
E76.2 Other mucopolysaccharidoses
0.000 0.623 0.376
E76.1 Mucopolysaccharidosis, type II
0.000 0.623 0.376
E76.0 Mucopolysaccharidosis, type I
0.000 0.623 0.376
E77.9 Disorder of glycoprotein metabolism, unspecified
0.000 0.623 0.376
E77.8 Other disorders of glycoprotein metabolism
0.000 0.623 0.376
E77.1 Defects in glycoprotein degradation
0.000 0.623 0.376
E77.0 Defects in posttranslational modification of lysosomal enzymes
0.000 0.623 0.376
E79.9 Disorder of purine and pyrimidine metabolism, unspecified
0.000 0.623 0.376
E79.8 Other disorders of purine and pyrimidine metabolism
0.000 0.623 0.376
E79.1 Lesch-Nyhan syndrome
0.000 0.623 0.376
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
0.000 0.623 0.376
E84.9 Cystic fibrosis, unspecified
0.000 0.623 0.376
E84.8 Cystic fibrosis with other manifestations
0.000 0.623 0.376
E84.1 Cystic fibrosis with intestinal manifestations
0.000 0.623 0.376
E84.0 Cystic fibrosis with pulmonary manifestations
0.000 0.623 0.376
E24 Cushing's syndrome
0.001 0.625 0.374
E44 Protein-energy malnutrition of moderate and mild degree
0.001 0.627 0.372
E45 Retarded development following protein-energy malnutrition
0.001 0.627 0.372
E43 Unspecified severe protein-energy malnutrition
0.001 0.627 0.372
E42 Marasmic kwashiorkor
0.001 0.627 0.372
E41 Nutritional marasmus
0.001 0.627 0.372
E40 Kwashiorkor
0.001 0.627 0.372
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.000 0.630 0.370
E50.9 Vitamin A deficiency, unspecified
0.000 0.630 0.369
E50.8 Other manifestations of vitamin A deficiency
0.000 0.630 0.369
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.630 0.369
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.630 0.369
E50.5 Vitamin A deficiency with night blindness
0.000 0.630 0.369
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.630 0.369
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.630 0.369
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.630 0.369
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.630 0.369
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.630 0.369
E51.9 Thiamine deficiency, unspecified
0.000 0.630 0.369
E51.8 Other manifestations of thiamine deficiency
0.000 0.630 0.369
E51.2 Wernicke's encephalopathy
0.000 0.630 0.369
E51.1 Beriberi
0.000 0.630 0.369
E56.9 Vitamin deficiency, unspecified
0.000 0.630 0.369
E56.8 Deficiency of other vitamins
0.000 0.630 0.369
E56.1 Deficiency of vitamin K
0.000 0.630 0.369
E56.0 Deficiency of vitamin E
0.000 0.630 0.369
E63.9 Nutritional deficiency, unspecified
0.000 0.630 0.369
E63.8 Other specified nutritional deficiencies
0.000 0.630 0.369
E63.1 Imbalance of constituents of food intake
0.000 0.630 0.369
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.630 0.369
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.630 0.369
E64.8 Sequelae of other nutritional deficiencies
0.000 0.630 0.369
E64.3 Sequelae of rickets
0.000 0.630 0.369
E64.2 Sequelae of vitamin C deficiency
0.000 0.630 0.369
E64.1 Sequelae of vitamin A deficiency
0.000 0.630 0.369
E64.0 Sequelae of protein-energy malnutrition
0.000 0.630 0.369
E87.2 Acidosis
0.000 0.632 0.368
E13.8 With unspecified complications
0.001 0.633 0.366
E13.7 With multiple complications
0.001 0.633 0.366
E13.6 With other specified complications
0.001 0.633 0.366
E13.5 With peripheral circulatory complications
0.001 0.633 0.366
E13.4 With neurological complications
0.001 0.633 0.366
E13.3 With ophthalmic complications
0.001 0.633 0.366
E13.2 With renal complications
0.001 0.633 0.366
E13.1 With ketoacidosis
0.001 0.633 0.366
E13.0 With coma
0.001 0.633 0.366
E85.8 Other amyloidosis
0.000 0.634 0.365
E85.2 Heredofamilial amyloidosis, unspecified
0.000 0.634 0.365
E85.1 Neuropathic heredofamilial amyloidosis
0.000 0.634 0.365
E85.0 Nonneuropathic heredofamilial amyloidosis
0.000 0.634 0.365
E29.9 Testicular dysfunction, unspecified
0.000 0.636 0.364
E29.8 Other testicular dysfunction
0.000 0.636 0.364
E29.0 Testicular hyperfunction
0.000 0.636 0.364
E74.9 Disorder of carbohydrate metabolism, unspecified
0.000 0.637 0.363
E74.8 Other specified disorders of carbohydrate metabolism
0.000 0.637 0.363
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
0.000 0.637 0.363
E74.2 Disorders of galactose metabolism
0.000 0.637 0.363
E74.1 Disorders of fructose metabolism
0.000 0.637 0.363
E74.0 Glycogen storage disease
0.000 0.637 0.363
E14.9 Without complications
0.000 0.642 0.358
E85.4 Organ-limited amyloidosis
0.000 0.643 0.357
E23.7 Disorder of pituitary gland, unspecified
0.000 0.645 0.355
E26.9 Hyperaldosteronism, unspecified
0.000 0.648 0.351
E55.0 Rickets, active
0.000 0.649 0.351
E74.3 Other disorders of intestinal carbohydrate absorption
0.000 0.655 0.345
E85.9 Amyloidosis, unspecified
0.000 0.655 0.345
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.000 0.660 0.340
E80.7 Disorder of bilirubin metabolism, unspecified
0.000 0.660 0.340
E80.5 Crigler-Najjar syndrome
0.000 0.660 0.340
E80.3 Defects of catalase and peroxydase
0.000 0.660 0.340
E80.2 Other porphyria
0.000 0.660 0.340
E80.1 Porphyria cutanea tarda
0.000 0.660 0.340
E80.0 Hereditary erythropoietic porphyria
0.000 0.660 0.340
E80.6 Other disorders of bilirubin metabolism
0.000 0.666 0.334
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.000 0.667 0.333
E23.1 Drug-induced hypopituitarism
0.000 0.667 0.333
E23.6 Other disorders of pituitary gland
0.000 0.667 0.333
E55.9 Vitamin D deficiency, unspecified
0.000 0.675 0.325
E87.3 Alkalosis
0.000 0.677 0.323
E65-E68 Obesity and other hyperalimentation
0.000 0.678 0.322
K90.3 Pancreatic steatorrhoea
0.000 0.678 0.322
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.678 0.322
K90.1 Tropical sprue
0.000 0.678 0.322
E88.0 Disorders of plasma-protein metabolism, not elsewhere classified
0.000 0.681 0.319
E73.8 Other lactose intolerance
0.000 0.687 0.313
E73.1 Secondary lactase deficiency
0.000 0.687 0.313
E73.0 Congenital lactase deficiency
0.000 0.687 0.313
K90.8 Other intestinal malabsorption
0.000 0.690 0.310
E88.9 Metabolic disorder, unspecified
0.000 0.692 0.307
E88.3 Tumour lysis syndrome
0.000 0.692 0.307
E88.1 Lipodystrophy, not elsewhere classified
0.000 0.692 0.307
E61.9 Deficiency of nutrient element, unspecified
0.000 0.694 0.306
E61.8 Deficiency of other specified nutrient elements
0.000 0.694 0.306
E61.7 Deficiency of multiple nutrient elements
0.000 0.694 0.306
E61.6 Vanadium deficiency
0.000 0.694 0.306
E61.5 Molybdenum deficiency
0.000 0.694 0.306
E61.4 Chromium deficiency
0.000 0.694 0.306
E61.3 Manganese deficiency
0.000 0.694 0.306
E61.0 Copper deficiency
0.000 0.694 0.306
E28.2 Polycystic ovarian syndrome
0.000 0.704 0.296
E80.4 Gilbert's syndrome
0.000 0.704 0.296
E61.2 Magnesium deficiency
0.000 0.704 0.295
E00-E07 Disorders of thyroid gland
0.000 0.718 0.282
E88.2 Lipomatosis, not elsewhere classified
0.000 0.723 0.276
E83.5 Disorders of calcium metabolism
0.000 0.725 0.275
E21.3 Hyperparathyroidism, unspecified
0.000 0.725 0.275
E23.0 Hypopituitarism
0.000 0.726 0.274
E86 Volume depletion
0.000 0.730 0.270
E24.8 Other Cushing's syndrome
0.001 0.731 0.268
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.001 0.731 0.268
E24.3 Ectopic ACTH syndrome
0.001 0.731 0.268
E24.2 Drug-induced Cushing's syndrome
0.001 0.731 0.268
E24.1 Nelson's syndrome
0.001 0.731 0.268
E87.0 Hyperosmolality and hypernatraemia
0.000 0.732 0.268
E44.1 Mild protein-energy malnutrition
0.000 0.733 0.267
E44.0 Moderate protein-energy malnutrition
0.000 0.733 0.267
E21.2 Other hyperparathyroidism
0.000 0.735 0.265
E29.1 Testicular hypofunction
0.000 0.741 0.259
E21.5 Disorder of parathyroid gland, unspecified
0.000 0.752 0.248
E06 Thyroiditis
0.000 0.753 0.247
E88.8 Other specified metabolic disorders
0.000 0.762 0.238
E23.2 Diabetes insipidus
0.000 0.767 0.233
E61.1 Iron deficiency
0.000 0.767 0.233
E21.4 Other specified disorders of parathyroid gland
0.000 0.768 0.232
E67 Other hyperalimentation
0.000 0.769 0.231
E68 Sequelae of hyperalimentation
0.000 0.769 0.231
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.000 0.770 0.230
E73.9 Lactose intolerance, unspecified
0.000 0.775 0.225
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.000 0.789 0.210
E21.0 Primary hyperparathyroidism
0.000 0.794 0.206
E06.3 Autoimmune thyroiditis
0.000 0.795 0.205
E24.0 Pituitary-dependent Cushing's disease
0.001 0.796 0.203
E06.9 Thyroiditis, unspecified
0.000 0.796 0.204
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.797 0.202
E00 Congenital iodine-deficiency syndrome
0.000 0.797 0.202
E46 Unspecified protein-energy malnutrition
0.001 0.816 0.183
E04 Other non-toxic goitre
0.000 0.816 0.184
E06.5 Other chronic thyroiditis
0.000 0.823 0.177
E06.4 Drug-induced thyroiditis
0.000 0.823 0.177
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.823 0.177
E06.1 Subacute thyroiditis
0.000 0.823 0.177
E06.0 Acute thyroiditis
0.000 0.823 0.177
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.829 0.171
E65 Localised adiposity
0.000 0.829 0.170
E67.8 Other specified hyperalimentation
0.000 0.834 0.166
E67.3 Hypervitaminosis D
0.000 0.834 0.166
E67.2 Megavitamin-B6 syndrome
0.000 0.834 0.166
E67.1 Hypercarotenaemia
0.000 0.834 0.166
E67.0 Hypervitaminosis A
0.000 0.834 0.166
E13.9 Without complications
0.001 0.837 0.162
E24.9 Cushing's syndrome, unspecified
0.001 0.839 0.159
E87.7 Fluid overload
0.000 0.842 0.158
E07 Other disorders of thyroid
0.000 0.854 0.146
E04.0 Non-toxic diffuse goitre
0.000 0.854 0.145
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.000 0.854 0.145
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.000 0.854 0.145
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.000 0.854 0.145
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.000 0.854 0.145
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.854 0.145
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.000 0.854 0.145
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.000 0.854 0.145
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.000 0.854 0.145
E04.1 Non-toxic single thyroid nodule
0.000 0.858 0.142
E04.8 Other specified non-toxic goitre
0.000 0.868 0.132
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.876 0.124
E04.2 Non-toxic multinodular goitre
0.000 0.882 0.118
E87.6 Hypokalaemia
0.000 0.884 0.116
K90-K93 Other diseases of the digestive system
0.000 0.885 0.115
E07.1 Dyshormogenetic goitre
0.000 0.895 0.105
E07.0 Hypersecretion of calcitonin
0.000 0.895 0.105
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.906 0.094
E07.8 Other specified disorders of thyroid
0.000 0.907 0.093
K91 Postprocedural disorders of digestive system, not elsewhere classified
0.000 0.909 0.091
E04.9 Non-toxic goitre, unspecified
0.000 0.910 0.090
E03 Other hypothyroidism
0.000 0.911 0.089
E05.5 Thyroid crisis or storm
0.000 0.911 0.089
E05.4 Thyrotoxicosis factitia
0.000 0.911 0.089
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.911 0.089
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.911 0.089
K91.0 Vomiting following gastro-intestinal surgery
0.000 0.916 0.084
K93 Disorders of other digestive organs in diseases classified elsewhere
0.000 0.917 0.083
E05.8 Other thyrotoxicosis
0.000 0.919 0.080
K91.4 Colostomy and enterostomy malfunction
0.000 0.921 0.079
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.922 0.078
E07.9 Disorder of thyroid, unspecified
0.000 0.929 0.071
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.000 0.932 0.068
K91.2 Postsurgical malabsorption, not elsewhere classified
0.000 0.934 0.066
K91.9 Postprocedural disorder of digestive system, unspecified
0.000 0.934 0.065
K91.5 Postcholecystectomy syndrome
0.000 0.934 0.065
E03.5 Myxoedema coma
0.000 0.936 0.064
E03.4 Atrophy of thyroid (acquired)
0.000 0.936 0.064
E03.3 Postinfectious hypothyroidism
0.000 0.936 0.064
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.936 0.064
E03.1 Congenital hypothyroidism without goitre
0.000 0.936 0.064
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.936 0.064
K91.1 Postgastric surgery syndromes
0.000 0.937 0.063
K93.8 Disorders of other specified digestive organs in diseases classified elsewhere
0.000 0.940 0.059
K93.1 Megacolon in Chagas' disease
0.000 0.940 0.059
K93.0 Tuberculous disorders of intestines, peritoneum and mesenteric glands
0.000 0.940 0.059
E78.4 Other hyperlipidaemia
0.000 0.947 0.053
E78.9 Disorder of lipoprotein metabolism, unspecified
0.000 0.948 0.052
E78.1 Pure hyperglyceridaemia
0.000 0.949 0.051
E78.6 Lipoprotein deficiency
0.000 0.951 0.049
E78.3 Hyperchylomicronaemia
0.000 0.951 0.049
E03.8 Other specified hypothyroidism
0.000 0.951 0.048
K91.3 Postoperative intestinal obstruction
0.000 0.952 0.048
E05.9 Thyrotoxicosis, unspecified
0.000 0.957 0.043
E66 Obesity
0.000 0.965 0.035
E78.8 Other disorders of lipoprotein metabolism
0.000 0.966 0.034
E78.2 Mixed hyperlipidaemia
0.000 0.974 0.026
E66.1 Drug-induced obesity
0.000 0.974 0.025
K91.8 Other postprocedural disorders of digestive system, not elsewhere classified
0.000 0.975 0.025
K92 Other diseases of digestive system
0.000 0.976 0.024
E66.2 Extreme obesity with alveolar hypoventilation
0.000 0.977 0.022
G62.9 Polyneuropathy, unspecified
0.000 0.978 0.022
K92.8 Other specified diseases of digestive system
0.000 0.979 0.021
E66.0 Obesity due to excess calories
0.000 0.982 0.018
G62 Other polyneuropathies
0.000 0.982 0.018
K92.9 Disease of digestive system, unspecified
0.000 0.983 0.017
G62.0 Drug-induced polyneuropathy
0.000 0.984 0.016
G63.2 Diabetic polyneuropathy
0.000 0.985 0.015
G63 Polyneuropathy in diseases classified elsewhere
0.000 0.985 0.015
G60-G64 Polyneuropathies and other disorders of the peripheral nervous system
0.000 0.986 0.014
M31.3 Wegener's granulomatosis
0.014 0.986 0.000
G62.2 Polyneuropathy due to other toxic agents
0.000 0.987 0.013
M31.6 Other giant cell arteritis
0.013 0.987 0.000
M31 Other necrotising vasculopathies
0.012 0.988 0.000
E11.9 Without complications
0.000 0.989 0.011
G61 Inflammatory polyneuropathy
0.000 0.989 0.011
G62.1 Alcoholic polyneuropathy
0.000 0.989 0.011
G63.8 Polyneuropathy in other diseases classified elsewhere
0.000 0.989 0.011
G63.6 Polyneuropathy in other musculoskeletal disorders
0.000 0.989 0.011
G63.5 Polyneuropathy in systemic connective tissue disorders
0.000 0.989 0.011
G63.4 Polyneuropathy in nutritional deficiency
0.000 0.989 0.011
G63.3 Polyneuropathy in other endocrine and metabolic diseases
0.000 0.989 0.011
G63.1 Polyneuropathy in neoplastic disease
0.000 0.989 0.011
G63.0 Polyneuropathy in infectious and parasitic diseases classified elsewhere
0.000 0.989 0.011
J98.1 Pulmonary collapse
0.011 0.989 0.000
G64 Other disorders of peripheral nervous system
0.000 0.989 0.011
G62.8 Other specified polyneuropathies
0.000 0.989 0.011
G60 Hereditary and idiopathic neuropathy
0.000 0.990 0.010
K92.0 Haematemesis
0.000 0.990 0.010
G60.8 Other hereditary and idiopathic neuropathies
0.000 0.991 0.009
G61.0 Guillain-Barre syndrome
0.000 0.991 0.009
N83.8 Other noninflammatory disorders of ovary, Fallopian tube and broad ligament
0.000 0.991 0.009
E66.8 Other obesity
0.000 0.991 0.009
M31.9 Necrotising vasculopathy, unspecified
0.008 0.991 0.000
M31.8 Other specified necrotising vasculopathies
0.008 0.991 0.000
M31.7 Microscopic polyangiitis
0.008 0.991 0.000
M31.4 Aortic arch syndrome [Takayasu]
0.008 0.991 0.000
M31.2 Lethal midline granuloma
0.008 0.991 0.000
M31.1 Thrombotic microangiopathy
0.008 0.991 0.000
M31.0 Hypersensitivity angiitis
0.008 0.991 0.000
G61.1 Serum neuropathy
0.000 0.992 0.008
G61.8 Other inflammatory polyneuropathies
0.000 0.992 0.008
G61.9 Inflammatory polyneuropathy, unspecified
0.000 0.992 0.008
G60.9 Hereditary and idiopathic neuropathy, unspecified
0.000 0.992 0.007
G60.3 Idiopathic progressive neuropathy
0.000 0.992 0.007
G60.2 Neuropathy in association with hereditary ataxia
0.000 0.992 0.007
G60.1 Refsum's disease
0.000 0.992 0.007
M31.5 Giant cell arteritis with polymyalgia rheumatica
0.007 0.993 0.000
W19.9 Unspecified place
0.000 0.993 0.007
M20.5 Other deformities of toe(s) (acquired)
0.006 0.994 0.000
I80.1 Phlebitis and thrombophlebitis of femoral vein
0.006 0.994 0.000
I35.0 Aortic (valve) stenosis
0.006 0.994 0.000
N08.3 Glomerular disorders in diabetes mellitus
0.000 0.994 0.006
M65.34 Trigger finger-Hand
0.000 0.994 0.006
H36.0 Diabetic retinopathy
0.000 0.995 0.005
K92.2 Gastro-intestinal haemorrhage, unspecified
0.000 0.995 0.005
Z87.8 Personal history of other specified conditions
0.000 0.995 0.005
G56.0 Carpal tunnel syndrome
0.000 0.995 0.005
G80.9 Infantile cerebral palsy, unspecified
0.005 0.995 0.000
M21.07 Valgus deformity, not elsewhere classified (Ankle and foot)
0.005 0.995 0.000
G60.0 Hereditary motor and sensory neuropathy
0.001 0.995 0.004
L29.9 Pruritus, unspecified
0.000 0.996 0.004
Z50.7 Occupational therapy and vocational rehabilitation, not elsewhere classified
0.000 0.996 0.004
H18.2 Other corneal oedema
0.004 0.996 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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