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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs2395045
log Bayes Factor = 80.7022
Chromosome 6   position 31,484,517  (GRCh37) Explore rs2395045 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E03.9 Hypothyroidism, unspecified
0.000 0.000 1.000
E10.9 Without complications
0.000 0.000 1.000
K90.0 Coeliac disease
0.000 0.000 1.000
L40.9 Psoriasis, unspecified
1.000 0.000 0.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
G35 Multiple sclerosis
1.000 0.000 0.000
E10-E14 Diabetes mellitus
0.000 0.000 1.000
E10.3 With ophthalmic complications
0.000 0.000 1.000
E00-E07 Disorders of thyroid gland
0.000 0.000 1.000
J45.9 Asthma, unspecified
0.000 0.000 1.000
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.000 1.000
E03 Other hypothyroidism
0.000 0.000 1.000
E14 Unspecified diabetes mellitus
0.000 0.001 0.999
E05.9 Thyrotoxicosis, unspecified
0.000 0.002 0.998
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.003 0.997
E10.4 With neurological complications
0.000 0.004 0.996
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.010 0.990
I20-I25 Ischaemic heart diseases
0.000 0.011 0.989
I20.9 Angina pectoris, unspecified
0.000 0.012 0.988
I20 Angina pectoris
0.000 0.013 0.987
I25 Chronic ischaemic heart disease
0.000 0.015 0.985
E14.9 Without complications
0.000 0.016 0.984
E14.3 With ophthalmic complications
0.000 0.017 0.983
I22 Subsequent myocardial infarction
0.000 0.018 0.982
E10.1 With ketoacidosis
0.000 0.019 0.981
M45.X9 Ankylosing spondylitis (Site unspecified)
0.000 0.025 0.975
I22.9 Subsequent myocardial infarction of unspecified site
0.000 0.036 0.964
L40 Psoriasis
0.951 0.049 0.000
I25.5 Ischaemic cardiomyopathy
0.000 0.053 0.947
I25.1 Atherosclerotic heart disease
0.000 0.054 0.946
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.058 0.942
G35-G37 Demyelinating diseases of the central nervous system
0.936 0.064 0.000
G37 Other demyelinating diseases of central nervous system
0.924 0.076 0.000
I22.1 Subsequent myocardial infarction of inferior wall
0.000 0.080 0.920
E10.2 With renal complications
0.000 0.086 0.914
L40.0 Psoriasis vulgaris
0.906 0.094 0.000
G37.9 Demyelinating disease of central nervous system, unspecified
0.903 0.097 0.000
E16 Other disorders of pancreatic internal secretion
0.000 0.097 0.903
M45 Ankylosing spondylitis
0.000 0.105 0.895
E13 Other specified diabetes mellitus
0.000 0.116 0.884
I25.8 Other forms of chronic ischaemic heart disease
0.000 0.118 0.882
L40.5 Arthropathic psoriasis
0.878 0.122 0.000
E07 Other disorders of thyroid
0.000 0.130 0.870
I25.2 Old myocardial infarction
0.000 0.133 0.867
E83.1 Disorders of iron metabolism
0.855 0.145 0.000
E10.5 With peripheral circulatory complications
0.000 0.152 0.848
M45.X0 Ankylosing spondylitis (Multiple sites in spine)
0.000 0.169 0.831
I24 Other acute ischaemic heart diseases
0.000 0.172 0.828
E10.0 With coma
0.000 0.172 0.828
M45.X2 Ankylosing spondylitis (Cervical region)
0.000 0.173 0.827
I20.1 Angina pectoris with documented spasm
0.000 0.180 0.820
E16.2 Hypoglycaemia, unspecified
0.000 0.184 0.816
I23 Certain current complications following acute myocardial infarction
0.000 0.185 0.815
I25.3 Aneurysm of heart
0.000 0.186 0.814
E07.9 Disorder of thyroid, unspecified
0.000 0.195 0.805
E13.9 Without complications
0.000 0.196 0.804
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.198 0.802
E14.8 With unspecified complications
0.000 0.198 0.802
G37.8 Other specified demyelinating diseases of central nervous system
0.780 0.220 0.000
E11 Non-insulin-dependent diabetes mellitus
0.000 0.223 0.777
E14.6 With other specified complications
0.000 0.229 0.771
I24.9 Acute ischaemic heart disease, unspecified
0.000 0.245 0.755
I22.0 Subsequent myocardial infarction of anterior wall
0.000 0.252 0.748
L40.1 Generalised pustular psoriasis
0.743 0.257 0.000
E11.9 Without complications
0.000 0.257 0.743
E14.1 With ketoacidosis
0.000 0.259 0.741
G37.3 Acute transverse myelitis in demyelinating disease of central nervous system
0.739 0.260 0.000
E10.8 With unspecified complications
0.000 0.262 0.738
E14.5 With peripheral circulatory complications
0.000 0.275 0.725
E10.7 With multiple complications
0.000 0.283 0.717
E12 Malnutrition-related diabetes mellitus
0.000 0.283 0.717
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.283 0.717
E00 Congenital iodine-deficiency syndrome
0.000 0.283 0.717
E05.5 Thyroid crisis or storm
0.000 0.283 0.717
E05.4 Thyrotoxicosis factitia
0.000 0.283 0.717
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.283 0.717
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.283 0.717
E03.5 Myxoedema coma
0.000 0.283 0.717
E03.4 Atrophy of thyroid (acquired)
0.000 0.283 0.717
E03.3 Postinfectious hypothyroidism
0.000 0.283 0.717
E14.7 With multiple complications
0.000 0.283 0.716
E14.2 Withrenal complications
0.000 0.283 0.716
E14.0 With coma
0.000 0.283 0.716
E10.6 With other specified complications
0.000 0.291 0.709
E14.4 With neurological complications
0.000 0.292 0.708
I25.6 Silent myocardial ischaemia
0.000 0.294 0.706
E11.0 With coma
0.000 0.295 0.705
I20.0 Unstable angina
0.000 0.309 0.691
E16.1 Other hypoglycaemia
0.000 0.309 0.691
I23.8 Other current complications following acute myocardial infarction
0.000 0.310 0.690
E03.1 Congenital hypothyroidism without goitre
0.000 0.313 0.687
E06 Thyroiditis
0.000 0.313 0.687
L40.4 Guttate psoriasis
0.682 0.318 0.000
L40.2 Acrodermatitis continua
0.682 0.318 0.000
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.323 0.677
E15 Nondiabetic hypoglycaemic coma
0.000 0.324 0.675
L40.3 Pustulosis palmaris et plantaris
0.671 0.329 0.000
E05.8 Other thyrotoxicosis
0.000 0.329 0.670
G37.5 Concentric sclerosis [Balo]
0.663 0.337 0.000
G37.4 Subacute necrotising myelitis
0.663 0.337 0.000
G37.2 Central pontine myelinolysis
0.663 0.337 0.000
G37.1 Central demyelination of corpus callosum
0.663 0.337 0.000
G37.0 Diffuse sclerosis
0.663 0.337 0.000
I24.0 Coronary thrombosis not resulting in myocardial infarction
0.000 0.338 0.662
I25.0 Atherosclerotic cardiovascular disease, so described
0.000 0.343 0.657
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.353 0.647
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.353 0.647
E16.4 Abnormal secretion of gastrin
0.000 0.353 0.647
E16.3 Increased secretion of glucagon
0.000 0.353 0.647
G36 Other acute disseminated demyelination
0.647 0.353 0.000
M45.X8 Ankylosing spondylitis (Sacral and sacrococcygeal region)
0.000 0.358 0.641
M45.X7 Ankylosing spondylitis (Lumbosacral region)
0.000 0.358 0.641
M45.X6 Ankylosing spondylitis (Lumbar region)
0.000 0.358 0.641
M45.X5 Ankylosing spondylitis (Thoracolumbar region)
0.000 0.358 0.641
M45.X4 Ankylosing spondylitis (Thoracic region)
0.000 0.358 0.641
M45.X3 Ankylosing spondylitis (Cervicothoracic region)
0.000 0.358 0.641
M45.X1 Ankylosing spondylitis (Occipito-atlanto-axial region)
0.000 0.358 0.641
E11.6 With other specified complications
0.000 0.361 0.639
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.366 0.634
E13.8 With unspecified complications
0.000 0.366 0.634
E13.7 With multiple complications
0.000 0.366 0.634
E13.6 With other specified complications
0.000 0.366 0.634
E13.5 With peripheral circulatory complications
0.000 0.366 0.634
E13.4 With neurological complications
0.000 0.366 0.634
E13.2 With renal complications
0.000 0.366 0.634
E13.1 With ketoacidosis
0.000 0.366 0.634
E13.0 With coma
0.000 0.366 0.634
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.370 0.630
E07.1 Dyshormogenetic goitre
0.000 0.376 0.624
E07.0 Hypersecretion of calcitonin
0.000 0.376 0.624
E13.3 With ophthalmic complications
0.000 0.377 0.623
K90 Intestinal malabsorption
0.000 0.396 0.604
L40.8 Other psoriasis
0.604 0.396 0.000
I23.6 Thrombosis of atrium, auricular appendage and ventricle as current complications following acute myocardial infarction
0.000 0.416 0.584
I23.5 Rupture of papillary muscle as current complication following acute myocardial infarction
0.000 0.416 0.584
I23.4 Rupture of chordae tendineae as current complication following acute myocardial infarction
0.000 0.416 0.584
I23.3 Rupture of cardiac wall without haemopericardium as current complication following acute myocardial infarction
0.000 0.416 0.584
I23.2 Ventricular septal defect as current complication following acute myocardial infarction
0.000 0.416 0.584
I23.1 Atrial septal defect as current complication following acute myocardial infarction
0.000 0.416 0.584
I23.0 Haemopericardium as current complication following acute myocardial infarction
0.000 0.416 0.584
E40-E46 Malnutrition
0.000 0.425 0.575
E11.7 With multiple complications
0.000 0.443 0.557
I22.8 Subsequent myocardial infarction of other sites
0.000 0.446 0.553
I25.4 Coronary artery aneurysm
0.000 0.454 0.545
E06.9 Thyroiditis, unspecified
0.000 0.467 0.533
I24.1 Dressler's syndrome
0.000 0.468 0.532
K90.9 Intestinal malabsorption, unspecified
0.000 0.476 0.524
E65-E68 Obesity and other hyperalimentation
0.000 0.480 0.520
E07.8 Other specified disorders of thyroid
0.000 0.480 0.519
E12.9 Without complications
0.000 0.486 0.514
E12.8 With unspecified complications
0.000 0.486 0.514
E12.7 With multiple complications
0.000 0.486 0.514
E12.6 With other specified complications
0.000 0.486 0.514
E12.5 With peripheral circulatory complications
0.000 0.486 0.514
E12.4 With neurological complications
0.000 0.486 0.514
E12.3 With ophthalmic complications
0.000 0.486 0.514
E12.2 With renal complications
0.000 0.486 0.514
E12.1 With ketoacidosis
0.000 0.486 0.514
E12.0 With coma
0.000 0.486 0.514
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.000 0.486 0.514
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.000 0.486 0.514
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.000 0.486 0.514
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.000 0.486 0.514
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.486 0.514
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.000 0.486 0.514
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.000 0.486 0.514
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.000 0.486 0.514
E06.5 Other chronic thyroiditis
0.000 0.508 0.492
E06.4 Drug-induced thyroiditis
0.000 0.508 0.492
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.508 0.492
E06.1 Subacute thyroiditis
0.000 0.508 0.492
E06.0 Acute thyroiditis
0.000 0.508 0.492
E11.5 With peripheral circulatory complications
0.000 0.513 0.487
K90.8 Other intestinal malabsorption
0.000 0.526 0.474
E11.1 With ketoacidosis
0.000 0.529 0.470
E11.2 With renal complications
0.000 0.533 0.467
G36.9 Acute disseminated demyelination, unspecified
0.464 0.536 0.000
G36.8 Other specified acute disseminated demyelination
0.464 0.536 0.000
G36.1 Acute and subacute haemorrhagic leukoencephalitis [Hurst]
0.464 0.536 0.000
I21 Acute myocardial infarction
0.000 0.538 0.462
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.545 0.454
E50-E64 Other nutritional deficiencies
0.000 0.548 0.452
E03.8 Other specified hypothyroidism
0.001 0.551 0.448
G36.0 Neuromyelitis optica [Devic]
0.439 0.560 0.000
K90.3 Pancreatic steatorrhoea
0.000 0.567 0.433
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.567 0.433
K90.1 Tropical sprue
0.000 0.567 0.433
I24.8 Other forms of acute ischaemic heart disease
0.000 0.580 0.420
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.587 0.412
E45 Retarded development following protein-energy malnutrition
0.000 0.587 0.412
E43 Unspecified severe protein-energy malnutrition
0.000 0.587 0.412
E42 Marasmic kwashiorkor
0.000 0.587 0.412
E41 Nutritional marasmus
0.000 0.587 0.412
E40 Kwashiorkor
0.000 0.587 0.412
I21.2 Acute transmural myocardial infarction of other sites
0.000 0.588 0.412
E06.3 Autoimmune thyroiditis
0.000 0.597 0.403
E11.8 With unspecified complications
0.000 0.605 0.395
E65 Localised adiposity
0.000 0.607 0.393
I21.0 Acute transmural myocardial infarction of anterior wall
0.000 0.627 0.373
E67 Other hyperalimentation
0.000 0.627 0.373
E68 Sequelae of hyperalimentation
0.000 0.627 0.373
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.000 0.635 0.365
E61 Deficiency of other nutrient elements
0.000 0.657 0.343
I21.X Presumed acute myicardial infaction (unconfirmed)
0.000 0.668 0.332
E11.3 With ophthalmic complications
0.000 0.671 0.329
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.676 0.324
E63 Other nutritional deficiencies
0.000 0.676 0.324
E51 Thiamine deficiency
0.000 0.676 0.324
E50 Vitamin A deficiency
0.000 0.676 0.324
E60 Dietary zinc deficiency
0.000 0.676 0.324
E59 Dietary selenium deficiency
0.000 0.676 0.324
E58 Dietary calcium deficiency
0.000 0.676 0.324
E54 Ascorbic acid deficiency
0.000 0.676 0.324
E52 Niacin deficiency [pellagra]
0.000 0.676 0.324
E56 Other vitamin deficiencies
0.000 0.684 0.316
I21.9 Acute myocardial infarction, unspecified
0.000 0.685 0.315
E44.1 Mild protein-energy malnutrition
0.000 0.704 0.296
E44.0 Moderate protein-energy malnutrition
0.000 0.704 0.296
E46 Unspecified protein-energy malnutrition
0.000 0.727 0.273
E67.8 Other specified hyperalimentation
0.000 0.732 0.267
E67.3 Hypervitaminosis D
0.000 0.732 0.267
E67.2 Megavitamin-B6 syndrome
0.000 0.732 0.267
E67.1 Hypercarotenaemia
0.000 0.732 0.267
E67.0 Hypervitaminosis A
0.000 0.732 0.267
E61.2 Magnesium deficiency
0.000 0.733 0.267
I21.3 Acute transmural myocardial infarction of unspecified site
0.000 0.735 0.265
E55 Vitamin D deficiency
0.000 0.737 0.263
E61.9 Deficiency of nutrient element, unspecified
0.000 0.754 0.246
E61.8 Deficiency of other specified nutrient elements
0.000 0.754 0.246
E61.7 Deficiency of multiple nutrient elements
0.000 0.754 0.246
E61.6 Vanadium deficiency
0.000 0.754 0.246
E61.5 Molybdenum deficiency
0.000 0.754 0.246
E61.4 Chromium deficiency
0.000 0.754 0.246
E61.3 Manganese deficiency
0.000 0.754 0.246
E61.0 Copper deficiency
0.000 0.754 0.246
E61.1 Iron deficiency
0.000 0.756 0.244
E11.4 With neurological complications
0.000 0.764 0.236
E50.9 Vitamin A deficiency, unspecified
0.000 0.767 0.232
E50.8 Other manifestations of vitamin A deficiency
0.000 0.767 0.232
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.767 0.232
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.767 0.232
E50.5 Vitamin A deficiency with night blindness
0.000 0.767 0.232
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.767 0.232
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.767 0.232
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.767 0.232
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.767 0.232
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.767 0.232
E51.9 Thiamine deficiency, unspecified
0.000 0.767 0.232
E51.8 Other manifestations of thiamine deficiency
0.000 0.767 0.232
E51.2 Wernicke's encephalopathy
0.000 0.767 0.232
E51.1 Beriberi
0.000 0.767 0.232
E63.9 Nutritional deficiency, unspecified
0.000 0.767 0.232
E63.8 Other specified nutritional deficiencies
0.000 0.767 0.232
E63.1 Imbalance of constituents of food intake
0.000 0.767 0.232
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.767 0.232
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.767 0.232
E64.8 Sequelae of other nutritional deficiencies
0.000 0.767 0.232
E64.3 Sequelae of rickets
0.000 0.767 0.232
E64.2 Sequelae of vitamin C deficiency
0.000 0.767 0.232
E64.1 Sequelae of vitamin A deficiency
0.000 0.767 0.232
E64.0 Sequelae of protein-energy malnutrition
0.000 0.767 0.232
E56.9 Vitamin deficiency, unspecified
0.000 0.773 0.226
E56.8 Deficiency of other vitamins
0.000 0.773 0.226
E56.0 Deficiency of vitamin E
0.000 0.773 0.226
L40-L45 Papulosquamous disorders
0.218 0.775 0.007
E56.1 Deficiency of vitamin K
0.000 0.782 0.218
E55.0 Rickets, active
0.000 0.811 0.188
J45 Asthma
0.000 0.819 0.181
L44 Other papulosquamous disorders
0.164 0.831 0.005
L41 Parapsoriasis
0.157 0.839 0.005
L45 Papulosquamous disorders in diseases classified elsewhere
0.157 0.839 0.005
E53 Deficiency of other B group vitamins
0.000 0.839 0.161
L42 Pityriasis rosea
0.151 0.844 0.005
I21.4 Acute subendocardial myocardial infarction
0.000 0.849 0.151
E83 Disorders of mineral metabolism
0.125 0.850 0.024
J45.1 Nonallergic asthma
0.000 0.870 0.130
L44.0 Pityriasis rubra pilaris
0.126 0.871 0.003
E55.9 Vitamin D deficiency, unspecified
0.000 0.873 0.127
I20.8 Other forms of angina pectoris
0.000 0.873 0.126
J45.8 Mixed asthma
0.000 0.876 0.124
E66 Obesity
0.000 0.877 0.123
L44.9 Papulosquamous disorder, unspecified
0.118 0.879 0.003
L44.8 Other specified papulosquamous disorders
0.118 0.879 0.003
L44.4 Infantile papular acrodermatitis [Giannotti-Crosti]
0.118 0.879 0.003
L44.3 Lichen ruber moniliformis
0.118 0.879 0.003
L44.2 Lichen striatus
0.118 0.879 0.003
L44.1 Lichen nitidus
0.118 0.879 0.003
L41.9 Parapsoriasis, unspecified
0.112 0.884 0.004
L41.8 Other parapsoriasis
0.112 0.884 0.004
L41.5 Retiform parapsoriasis
0.112 0.884 0.004
L41.4 Large plaque parapsoriasis
0.112 0.884 0.004
L41.3 Small plaque parapsoriasis
0.112 0.884 0.004
L41.2 Lymphomatoid papulosis
0.112 0.884 0.004
L41.1 Pityriasis lichenoides chronica
0.112 0.884 0.004
L41.0 Pityriasis lichenoides et varioliformis acuta
0.112 0.884 0.004
E53.1 Pyridoxine deficiency
0.000 0.884 0.116
E53.0 Riboflavin deficiency
0.000 0.884 0.116
E83.3 Disorders of phosphorus metabolism
0.105 0.887 0.008
I21.1 Acute transmural myocardial infarction of inferior wall
0.000 0.891 0.109
I25.9 Chronic ischaemic heart disease, unspecified
0.000 0.892 0.108
E83.9 Disorder of mineral metabolism, unspecified
0.090 0.892 0.018
E83.8 Other disorders of mineral metabolism
0.090 0.892 0.018
E83.2 Disorders of zinc metabolism
0.090 0.892 0.018
E83.0 Disorders of copper metabolism
0.090 0.892 0.018
E04 Other non-toxic goitre
0.000 0.894 0.106
E20-E35 Disorders of other endocrine glands
0.001 0.900 0.099
E66.0 Obesity due to excess calories
0.000 0.902 0.098
E53.9 Vitamin B deficiency, unspecified
0.000 0.907 0.092
E66.1 Drug-induced obesity
0.000 0.912 0.088
E66.2 Extreme obesity with alveolar hypoventilation
0.000 0.914 0.086
E22 Hyperfunction of pituitary gland
0.000 0.916 0.084
L43 Lichen planus
0.053 0.919 0.028
E04.8 Other specified non-toxic goitre
0.000 0.924 0.076
E29 Testicular dysfunction
0.000 0.925 0.074
E70-E90 Metabolic disorders
0.002 0.926 0.072
E35 Disorders of endocrine glands in diseases classified elsewhere
0.001 0.928 0.071
E32 Diseases of thymus
0.001 0.928 0.071
E31 Polyglandular dysfunction
0.001 0.928 0.071
E30 Disorders of puberty, not elsewhere classified
0.001 0.928 0.071
E22.1 Hyperprolactinaemia
0.000 0.930 0.070
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.000 0.930 0.070
E23 Hypofunction and other disorders of pituitary gland
0.000 0.931 0.069
E20 Hypoparathyroidism
0.001 0.934 0.065
E24 Cushing's syndrome
0.001 0.937 0.063
E26 Hyperaldosteronism
0.001 0.937 0.063
E85 Amyloidosis
0.001 0.938 0.061
E28 Ovarian dysfunction
0.000 0.938 0.062
E23.2 Diabetes insipidus
0.000 0.939 0.061
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.939 0.061
E22.8 Other hyperfunction of pituitary gland
0.000 0.939 0.061
E25 Adrenogenital disorders
0.001 0.939 0.060
L43.3 Subacute (active) lichen planus
0.038 0.941 0.020
L43.2 Lichenoid drug reaction
0.038 0.941 0.020
L43.1 Bullous lichen planus
0.038 0.941 0.020
L43.0 Hypertrophic lichen planus
0.038 0.941 0.020
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.000 0.941 0.058
E29.1 Testicular hypofunction
0.000 0.943 0.057
M75.0 Adhesive capsulitis of shoulder
0.000 0.944 0.056
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.000 0.944 0.056
E22.0 Acromegaly and pituitary gigantism
0.000 0.944 0.055
E79 Disorders of purine and pyrimidine metabolism
0.002 0.945 0.053
E23.6 Other disorders of pituitary gland
0.000 0.946 0.054
E85.9 Amyloidosis, unspecified
0.001 0.946 0.053
E29.9 Testicular dysfunction, unspecified
0.000 0.946 0.053
E29.8 Other testicular dysfunction
0.000 0.946 0.053
E29.0 Testicular hyperfunction
0.000 0.946 0.053
E77 Disorders of glycoprotein metabolism
0.002 0.946 0.052
E76 Disorders of glycosaminoglycan metabolism
0.002 0.946 0.052
E72 Other disorders of amino-acid metabolism
0.002 0.946 0.052
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.002 0.946 0.052
E70 Disorders of aromatic amino-acid metabolism
0.002 0.946 0.052
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.002 0.946 0.052
E74 Other disorders of carbohydrate metabolism
0.002 0.947 0.051
E73 Lactose intolerance
0.002 0.947 0.051
E89.3 Postprocedural hypopituitarism
0.000 0.948 0.052
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.002 0.948 0.050
E78.0 Pure hypercholesterolaemia
0.000 0.948 0.052
E30.9 Disorder of puberty, unspecified
0.001 0.948 0.051
E30.8 Other disorders of puberty
0.001 0.948 0.051
E30.1 Precocious puberty
0.001 0.948 0.051
E30.0 Delayed puberty
0.001 0.948 0.051
E31.9 Polyglandular dysfunction, unspecified
0.001 0.948 0.051
E31.8 Other polyglandular dysfunction
0.001 0.948 0.051
E31.1 Polyglandular hyperfunction
0.001 0.948 0.051
E31.0 Autoimmune polyglandular failure
0.001 0.948 0.051
E32.9 Disease of thymus, unspecified
0.001 0.948 0.051
E32.8 Other diseases of thymus
0.001 0.948 0.051
E32.1 Abscess of thymus
0.001 0.948 0.051
E32.0 Persistent hyperplasia of thymus
0.001 0.948 0.051
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.001 0.948 0.051
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.001 0.948 0.051
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.001 0.948 0.051
E04.0 Non-toxic diffuse goitre
0.000 0.948 0.051
E34 Other endocrine disorders
0.001 0.950 0.050
E84 Cystic fibrosis
0.002 0.950 0.048
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.000 0.950 0.049
E23.1 Drug-induced hypopituitarism
0.000 0.950 0.049
E89.6 Postprocedural adrenocortical(-medullary) hypofunction
0.000 0.951 0.048
E04.9 Non-toxic goitre, unspecified
0.000 0.952 0.048
E20.8 Other hypoparathyroidism
0.001 0.953 0.047
E20.1 Pseudohypoparathyroidism
0.001 0.953 0.047
E20.0 Idiopathic hypoparathyroidism
0.001 0.953 0.047
E78.8 Other disorders of lipoprotein metabolism
0.000 0.953 0.047
E28.3 Primary ovarian failure
0.000 0.954 0.046
L43.8 Other lichen planus
0.020 0.954 0.026
E85.3 Secondary systemic amyloidosis
0.001 0.954 0.045
E24.8 Other Cushing's syndrome
0.001 0.954 0.045
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.001 0.954 0.045
E24.3 Ectopic ACTH syndrome
0.001 0.954 0.045
E24.2 Drug-induced Cushing's syndrome
0.001 0.954 0.045
E24.1 Nelson's syndrome
0.001 0.954 0.045
E26.9 Hyperaldosteronism, unspecified
0.001 0.954 0.045
E26.8 Other hyperaldosteronism
0.001 0.954 0.045
E26.1 Secondary hyperaldosteronism
0.001 0.954 0.045
E24.0 Pituitary-dependent Cushing's disease
0.000 0.955 0.045
E85.8 Other amyloidosis
0.001 0.955 0.044
E85.2 Heredofamilial amyloidosis, unspecified
0.001 0.955 0.044
E85.1 Neuropathic heredofamilial amyloidosis
0.001 0.955 0.044
E85.0 Nonneuropathic heredofamilial amyloidosis
0.001 0.955 0.044
E28.9 Ovarian dysfunction, unspecified
0.000 0.955 0.044
E28.8 Other ovarian dysfunction
0.000 0.955 0.044
E28.1 Androgen excess
0.000 0.955 0.044
E28.0 Oestrogen excess
0.000 0.955 0.044
E04.1 Non-toxic single thyroid nodule
0.000 0.956 0.044
E78.1 Pure hyperglyceridaemia
0.000 0.956 0.044
E25.9 Adrenogenital disorder, unspecified
0.001 0.956 0.043
E25.8 Other adrenogenital disorders
0.001 0.956 0.043
E85.4 Organ-limited amyloidosis
0.001 0.957 0.042
E89.9 Postprocedural endocrine and metabolic disorder, unspecified
0.000 0.958 0.042
E89.8 Other postprocedural endocrine and metabolic disorders
0.000 0.958 0.042
E89.5 Postprocedural testicular hypofunction
0.000 0.958 0.042
E89.1 Postprocedural hypoinsulinaemia
0.000 0.958 0.042
E20.9 Hypoparathyroidism, unspecified
0.001 0.958 0.041
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
0.001 0.959 0.039
E74.3 Other disorders of intestinal carbohydrate absorption
0.001 0.960 0.039
E78.3 Hyperchylomicronaemia
0.000 0.960 0.040
E83.4 Disorders of magnesium metabolism
0.018 0.960 0.022
E23.7 Disorder of pituitary gland, unspecified
0.000 0.960 0.039
E78.6 Lipoprotein deficiency
0.000 0.960 0.039
E79.9 Disorder of purine and pyrimidine metabolism, unspecified
0.001 0.960 0.038
E79.8 Other disorders of purine and pyrimidine metabolism
0.001 0.960 0.038
E79.1 Lesch-Nyhan syndrome
0.001 0.960 0.038
K90-K93 Other diseases of the digestive system
0.000 0.961 0.039
M45-M49 Spondylopathies
0.000 0.961 0.039
E70.9 Disorder of aromatic amino-acid metabolism, unspecified
0.001 0.961 0.037
E70.8 Other disorders of aromatic amino-acid metabolism
0.001 0.961 0.037
E70.3 Albinism
0.001 0.961 0.037
E70.2 Disorders of tyrosine metabolism
0.001 0.961 0.037
E70.1 Other hyperphenylalaninaemias
0.001 0.961 0.037
E70.0 Classical phenylketonuria
0.001 0.961 0.037
E71.3 Disorders of fatty-acid metabolism
0.001 0.961 0.037
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified
0.001 0.961 0.037
E71.1 Other disorders of branched-chain amino-acid metabolism
0.001 0.961 0.037
E71.0 Maple-syrup-urine disease
0.001 0.961 0.037
E72.9 Disorder of amino-acid metabolism, unspecified
0.001 0.961 0.037
E72.8 Other specified disorders of amino-acid metabolism
0.001 0.961 0.037
E72.5 Disorders of glycine metabolism
0.001 0.961 0.037
E72.4 Disorders of ornithine metabolism
0.001 0.961 0.037
E72.3 Disorders of lysine and hydroxylysine metabolism
0.001 0.961 0.037
E72.2 Disorders of urea cycle metabolism
0.001 0.961 0.037
E72.1 Disorders of sulphur-bearing amino-acid metabolism
0.001 0.961 0.037
E72.0 Disorders of amino-acid transport
0.001 0.961 0.037
E76.9 Disorder of glucosaminoglycan metabolism, unspecified
0.001 0.961 0.037
E76.8 Other disorders of glucosaminoglycan metabolism
0.001 0.961 0.037
E76.3 Mucopolysaccharidosis, unspecified
0.001 0.961 0.037
E76.2 Other mucopolysaccharidoses
0.001 0.961 0.037
E76.1 Mucopolysaccharidosis, type II
0.001 0.961 0.037
E76.0 Mucopolysaccharidosis, type I
0.001 0.961 0.037
E77.9 Disorder of glycoprotein metabolism, unspecified
0.001 0.961 0.037
E77.8 Other disorders of glycoprotein metabolism
0.001 0.961 0.037
E77.1 Defects in glycoprotein degradation
0.001 0.961 0.037
E77.0 Defects in posttranslational modification of lysosomal enzymes
0.001 0.961 0.037
E83.5 Disorders of calcium metabolism
0.034 0.961 0.005
E78.2 Mixed hyperlipidaemia
0.000 0.961 0.039
E80 Disorders of porphyrin and bilirubin metabolism
0.002 0.962 0.037
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.000 0.962 0.038
E24.9 Cushing's syndrome, unspecified
0.000 0.962 0.038
E74.9 Disorder of carbohydrate metabolism, unspecified
0.001 0.962 0.037
E74.8 Other specified disorders of carbohydrate metabolism
0.001 0.962 0.037
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
0.001 0.962 0.037
E74.2 Disorders of galactose metabolism
0.001 0.962 0.037
E74.1 Disorders of fructose metabolism
0.001 0.962 0.037
E73.8 Other lactose intolerance
0.001 0.962 0.037
E73.1 Secondary lactase deficiency
0.001 0.962 0.037
E73.0 Congenital lactase deficiency
0.001 0.962 0.037
E89.2 Postprocedural hypoparathyroidism
0.000 0.962 0.038
E75.6 Lipid storage disorder, unspecified
0.001 0.962 0.036
E75.4 Neuronal ceroid lipofuscinosis
0.001 0.962 0.036
E75.3 Sphingolipidosis, unspecified
0.001 0.962 0.036
E75.2 Other sphingolipidosis
0.001 0.962 0.036
E75.1 Other gangliosidosis
0.001 0.962 0.036
E75.0 GM2 gangliosidosis
0.001 0.962 0.036
L43.9 Lichen planus, unspecified
0.002 0.963 0.035
E34.8 Other specified endocrine disorders
0.001 0.963 0.037
E26.0 Primary hyperaldosteronism
0.001 0.963 0.037
E73.9 Lactose intolerance, unspecified
0.001 0.963 0.036
E34.5 Androgen resistance syndrome
0.001 0.964 0.036
E34.4 Constitutional tall stature
0.001 0.964 0.036
E34.3 Short stature, not elsewhere classified
0.001 0.964 0.036
E34.2 Ectopic hormone secretion, not elsewhere classified
0.001 0.964 0.036
E34.1 Other hypersecretion of intestinal hormones
0.001 0.964 0.036
E84.8 Cystic fibrosis with other manifestations
0.001 0.964 0.035
E84.1 Cystic fibrosis with intestinal manifestations
0.001 0.964 0.035
E84.0 Cystic fibrosis with pulmonary manifestations
0.001 0.964 0.035
E75.5 Other lipid storage disorders
0.001 0.964 0.035
E89.4 Postprocedural ovarian failure
0.001 0.964 0.035
E78.4 Other hyperlipidaemia
0.000 0.965 0.035
E89.0 Postprocedural hypothyroidism
0.000 0.966 0.034
E74.0 Glycogen storage disease
0.001 0.966 0.032
E34.0 Carcinoid syndrome
0.001 0.967 0.032
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.001 0.967 0.032
E84.9 Cystic fibrosis, unspecified
0.002 0.967 0.031
E28.2 Polycystic ovarian syndrome
0.000 0.968 0.032
E88 Other metabolic disorders
0.002 0.968 0.030
J45.0 Predominantly allergic asthma
0.000 0.970 0.029
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.000 0.971 0.028
M49 Spondylopathies in diseases classified elsewhere
0.000 0.971 0.028
K93 Disorders of other digestive organs in diseases classified elsewhere
0.000 0.971 0.028
E80.1 Porphyria cutanea tarda
0.001 0.972 0.027
E80.6 Other disorders of bilirubin metabolism
0.001 0.972 0.027

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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