TreeWAS – Variant ID: rs2395264

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	Risk posterior probability	No effect posterior probability	Protective posterior probability
E10.9 Without complications	0.000	0.000	1.000
E10.3 With ophthalmic complications	0.000	0.000	1.000
K90.0 Coeliac disease	0.000	0.000	1.000
E10 Insulin-dependent diabetes mellitus	0.000	0.000	1.000
G35 Multiple sclerosis	0.000	0.000	1.000
E10.1 With ketoacidosis	0.000	0.000	1.000
Chapter IV Endocrine, nutritional and metabolic diseases	0.000	0.000	1.000
E05 Thyrotoxicosis [hyperthyroidism]	0.000	0.000	1.000
E05.0 Thyrotoxicosis with diffuse goitre	0.000	0.000	1.000
E10-E14 Diabetes mellitus	0.000	0.000	1.000
E16.2 Hypoglycaemia, unspecified	0.000	0.000	1.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion	0.000	0.000	1.000
E16 Other disorders of pancreatic internal secretion	0.000	0.001	0.999
E00-E07 Disorders of thyroid gland	0.000	0.001	0.999
E05.9 Thyrotoxicosis, unspecified	0.000	0.003	0.997
L40.9 Psoriasis, unspecified	0.996	0.004	0.000
E10.2 With renal complications	0.000	0.005	0.995
E10.4 With neurological complications	0.000	0.030	0.970
E50-E64 Other nutritional deficiencies	0.000	0.035	0.965
E10.5 With peripheral circulatory complications	0.000	0.044	0.956
E14 Unspecified diabetes mellitus	0.000	0.066	0.934
G35-G37 Demyelinating diseases of the central nervous system	0.000	0.072	0.928
E55 Vitamin D deficiency	0.000	0.075	0.925
G37 Other demyelinating diseases of central nervous system	0.000	0.095	0.905
L40 Psoriasis	0.897	0.103	0.000
E55.9 Vitamin D deficiency, unspecified	0.000	0.103	0.897
D86.9 Sarcoidosis, unspecified	0.000	0.106	0.894
D86 Sarcoidosis	0.000	0.117	0.883
D86.0 Sarcoidosis of lung	0.000	0.143	0.857
G37.9 Demyelinating disease of central nervous system, unspecified	0.000	0.161	0.839
E14.3 With ophthalmic complications	0.000	0.178	0.822
E14.8 With unspecified complications	0.000	0.180	0.820
E16.0 Drug-induced hypoglycaemia without coma	0.000	0.183	0.817
E14.6 With other specified complications	0.000	0.197	0.803
E10.0 With coma	0.000	0.204	0.796
L40.5 Arthropathic psoriasis	0.794	0.206	0.000
E53 Deficiency of other B group vitamins	0.000	0.210	0.790
E10.7 With multiple complications	0.000	0.210	0.790
G37.3 Acute transverse myelitis in demyelinating disease of central nervous system	0.000	0.223	0.777
L40.0 Psoriasis vulgaris	0.777	0.223	0.000
G37.8 Other specified demyelinating diseases of central nervous system	0.000	0.228	0.772
E40-E46 Malnutrition	0.000	0.231	0.769
E10.6 With other specified complications	0.000	0.240	0.760
D80-D89 Certain disorders involving the immune mechanism	0.000	0.241	0.759
E02 Subclinical iodine-deficiency hypothyroidism	0.000	0.257	0.743
D86.8 Sarcoidosis of other and combined sites	0.000	0.258	0.742
E10.8 With unspecified complications	0.000	0.265	0.735
M06.9 Rheumatoid arthritis, unspecified	0.727	0.273	0.000
D89 Other disorders involving the immune mechanism, not elsewhere classified	0.000	0.274	0.726
E14.2 Withrenal complications	0.000	0.275	0.725
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)	0.719	0.281	0.000
M06 Other rheumatoid arthritis	0.719	0.281	0.000
E51 Thiamine deficiency	0.000	0.283	0.717
E05.5 Thyroid crisis or storm	0.000	0.283	0.717
E05.4 Thyrotoxicosis factitia	0.000	0.283	0.717
E05.3 Thyrotoxicosis from ectopic thyroid tissue	0.000	0.283	0.717
E12 Malnutrition-related diabetes mellitus	0.000	0.283	0.717
E15 Nondiabetic hypoglycaemic coma	0.000	0.283	0.717
E16.9 Disorder of pancreatic internal secretion, unspecified	0.000	0.283	0.717
E16.8 Other specified disorders of pancreatic internal secretion	0.000	0.283	0.717
E16.4 Abnormal secretion of gastrin	0.000	0.283	0.717
E16.3 Increased secretion of glucagon	0.000	0.283	0.717
E01 Iodine-deficiency-related thyroid disorders and allied conditions	0.000	0.283	0.716
E00 Congenital iodine-deficiency syndrome	0.000	0.283	0.716
E61 Deficiency of other nutrient elements	0.000	0.288	0.712
K90 Intestinal malabsorption	0.000	0.302	0.698
G36 Other acute disseminated demyelination	0.000	0.302	0.698
D86.1 Sarcoidosis of lymph nodes	0.000	0.304	0.696
E05.1 Thyrotoxicosis with toxic single thyroid nodule	0.000	0.308	0.692
E64 Sequelae of malnutrition and other nutritional deficiencies	0.000	0.308	0.692
E63 Other nutritional deficiencies	0.000	0.308	0.692
E50 Vitamin A deficiency	0.000	0.308	0.692
E60 Dietary zinc deficiency	0.000	0.308	0.692
E59 Dietary selenium deficiency	0.000	0.308	0.692
E54 Ascorbic acid deficiency	0.000	0.308	0.692
E52 Niacin deficiency [pellagra]	0.000	0.308	0.692
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)	0.688	0.312	0.000
E56 Other vitamin deficiencies	0.000	0.316	0.683
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)	0.678	0.322	0.000
E20-E35 Disorders of other endocrine glands	0.000	0.324	0.676
M06.3 Rheumatoid nodule	0.675	0.325	0.000
E27.1 Primary adrenocortical insufficiency	0.000	0.328	0.672
D89.2 Hypergammaglobulinaemia, unspecified	0.000	0.328	0.672
E27 Other disorders of adrenal gland	0.000	0.328	0.672
E14.7 With multiple complications	0.000	0.330	0.670
E14.0 With coma	0.000	0.330	0.670
E55.0 Rickets, active	0.000	0.337	0.663
L40.1 Generalised pustular psoriasis	0.658	0.342	0.000
M06.0 Seronegative rheumatoid arthritis	0.655	0.345	0.000
L40.4 Guttate psoriasis	0.654	0.346	0.000
L40.3 Pustulosis palmaris et plantaris	0.652	0.347	0.000
E58 Dietary calcium deficiency	0.000	0.351	0.649
E14.5 With peripheral circulatory complications	0.000	0.351	0.649
G37.5 Concentric sclerosis [Balo]	0.000	0.351	0.649
G37.4 Subacute necrotising myelitis	0.000	0.351	0.649
G37.2 Central pontine myelinolysis	0.000	0.351	0.649
G37.1 Central demyelination of corpus callosum	0.000	0.351	0.649
G37.0 Diffuse sclerosis	0.000	0.351	0.649
D89.9 Disorder involving the immune mechanism, unspecified	0.000	0.352	0.648
E53.9 Vitamin B deficiency, unspecified	0.000	0.352	0.647
L40.2 Acrodermatitis continua	0.643	0.357	0.000
M05.9 Seropositive rheumatoid arthritis, unspecified	0.639	0.361	0.000
E13 Other specified diabetes mellitus	0.000	0.361	0.639
M05 Seropositive rheumatoid arthritis	0.637	0.363	0.000
M05-M14 Inflammatory polyarthropathies	0.634	0.366	0.000
E14.9 Without complications	0.000	0.366	0.634
K90.9 Intestinal malabsorption, unspecified	0.000	0.366	0.634
E05.2 Thyrotoxicosis with toxic multinodular goitre	0.000	0.378	0.622
M05.99 Seropositive rheumatoid arthritis, unspecified (Site unspecified)	0.620	0.380	0.000
E61.2 Magnesium deficiency	0.000	0.394	0.606
E14.1 With ketoacidosis	0.000	0.395	0.605
E46 Unspecified protein-energy malnutrition	0.000	0.397	0.603
L40.8 Other psoriasis	0.597	0.403	0.000
E53.8 Deficiency of other specified B group vitamins	0.000	0.405	0.595
E06 Thyroiditis	0.000	0.405	0.595
M06.93 Rheumatoid arthritis, unspecified (Forearm)	0.594	0.406	0.000
D86.2 Sarcoidosis of lung with sarcoidosis of lymph nodes	0.000	0.409	0.591
D82 Immunodeficiency associated with other major defects	0.000	0.411	0.588
D89.0 Polyclonal hypergammaglobulinaemia	0.000	0.418	0.581
M06.94 Rheumatoid arthritis, unspecified (Hand)	0.576	0.424	0.000
M06.32 Rheumatoid nodule (Upper arm)	0.575	0.424	0.000
M06.98 Rheumatoid arthritis, unspecified (Other)	0.575	0.425	0.000
E07 Other disorders of thyroid	0.000	0.429	0.570
M06.34 Rheumatoid nodule (Hand)	0.569	0.431	0.000
E53.1 Pyridoxine deficiency	0.000	0.433	0.567
E53.0 Riboflavin deficiency	0.000	0.433	0.567
E27.2 Addisonian crisis	0.000	0.437	0.563
E44 Protein-energy malnutrition of moderate and mild degree	0.000	0.449	0.551
E45 Retarded development following protein-energy malnutrition	0.000	0.449	0.551
E43 Unspecified severe protein-energy malnutrition	0.000	0.449	0.551
E42 Marasmic kwashiorkor	0.000	0.449	0.551
E41 Nutritional marasmus	0.000	0.449	0.551
E40 Kwashiorkor	0.000	0.449	0.551
L40-L45 Papulosquamous disorders	0.518	0.454	0.029
M05.90 Seropositive rheumatoid arthritis, unspecified (Multiple sites)	0.545	0.455	0.000
D81 Combined immunodeficiencies	0.000	0.456	0.544
D86.3 Sarcoidosis of skin	0.000	0.457	0.542
M06.33 Rheumatoid nodule (Forearm)	0.542	0.458	0.000
M06.07 Seronegative rheumatoid arthritis (Ankle and foot)	0.540	0.460	0.000
K90.4 Malabsorption due to intolerance, not elsewhere classified	0.000	0.460	0.540
E51.2 Wernicke's encephalopathy	0.000	0.460	0.539
E05.8 Other thyrotoxicosis	0.000	0.461	0.539
E20 Hypoparathyroidism	0.000	0.466	0.534
G36.0 Neuromyelitis optica [Devic]	0.000	0.466	0.534
M06.00 Seronegative rheumatoid arthritis (Multiple sites)	0.526	0.474	0.000
D80 Immunodeficiency with predominantly antibody defects	0.000	0.478	0.522
E27.8 Other specified disorders of adrenal gland	0.000	0.478	0.522
M06.36 Rheumatoid nodule (Lower leg)	0.521	0.479	0.000
D89.3 Immune reconstitution syndrome	0.000	0.480	0.520
E04 Other non-toxic goitre	0.000	0.482	0.518
M06.1 Adult-onset Still's disease	0.517	0.482	0.000
M06.2 Rheumatoid bursitis	0.515	0.485	0.000
E51.9 Thiamine deficiency, unspecified	0.000	0.486	0.514
E51.8 Other manifestations of thiamine deficiency	0.000	0.486	0.514
E51.1 Beriberi	0.000	0.486	0.514
E12.9 Without complications	0.000	0.486	0.514
E12.8 With unspecified complications	0.000	0.486	0.514
E12.7 With multiple complications	0.000	0.486	0.514
E12.6 With other specified complications	0.000	0.486	0.514
E12.5 With peripheral circulatory complications	0.000	0.486	0.514
E12.4 With neurological complications	0.000	0.486	0.514
E12.3 With ophthalmic complications	0.000	0.486	0.514
E12.2 With renal complications	0.000	0.486	0.514
E12.1 With ketoacidosis	0.000	0.486	0.514
E12.0 With coma	0.000	0.486	0.514
M05.95 Seropositive rheumatoid arthritis, unspecified (Pelvic region and thigh)	0.514	0.486	0.000
E00.9 Congenital iodine-deficiency syndrome, unspecified	0.000	0.486	0.514
E00.2 Congenital iodine-deficiency syndrome, mixed type	0.000	0.486	0.514
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type	0.000	0.486	0.514
E00.0 Congenital iodine-deficiency syndrome, neurological type	0.000	0.486	0.514
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions	0.000	0.486	0.514
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified	0.000	0.486	0.514
E01.1 Iodine-deficiency-related multinodular (endemic) goitre	0.000	0.486	0.514
E01.0 Iodine-deficiency-related diffuse (endemic) goitre	0.000	0.486	0.514
D83 Common variable immunodeficiency	0.000	0.488	0.511
M06.4 Inflammatory polyarthropathy	0.511	0.489	0.000
E61.9 Deficiency of nutrient element, unspecified	0.000	0.489	0.510
E61.8 Deficiency of other specified nutrient elements	0.000	0.489	0.510
E61.7 Deficiency of multiple nutrient elements	0.000	0.489	0.510
E61.6 Vanadium deficiency	0.000	0.489	0.510
E61.5 Molybdenum deficiency	0.000	0.489	0.510
E61.4 Chromium deficiency	0.000	0.489	0.510
E61.3 Manganese deficiency	0.000	0.489	0.510
E61.0 Copper deficiency	0.000	0.489	0.510
M06.06 Seronegative rheumatoid arthritis (Lower leg)	0.510	0.490	0.000
M06.01 Seronegative rheumatoid arthritis (Shoulder region)	0.509	0.491	0.000
M05.96 Seropositive rheumatoid arthritis, unspecified (Lower leg)	0.503	0.497	0.000
M05.94 Seropositive rheumatoid arthritis, unspecified (Hand)	0.501	0.499	0.000
E14.4 With neurological complications	0.000	0.499	0.501
K90.3 Pancreatic steatorrhoea	0.000	0.499	0.501
K90.2 Blind loop syndrome, not elsewhere classified	0.000	0.499	0.501
K90.1 Tropical sprue	0.000	0.499	0.501
G36.9 Acute disseminated demyelination, unspecified	0.000	0.499	0.501
G36.8 Other specified acute disseminated demyelination	0.000	0.499	0.501
G36.1 Acute and subacute haemorrhagic leukoencephalitis [Hurst]	0.000	0.499	0.501
M05.1 Rheumatoid lung disease	0.499	0.501	0.000
M05.93 Seropositive rheumatoid arthritis, unspecified (Forearm)	0.498	0.502	0.000
M05.8 Other seropositive rheumatoid arthritis	0.497	0.503	0.000
E31 Polyglandular dysfunction	0.000	0.503	0.497
M05.91 Seropositive rheumatoid arthritis, unspecified (Shoulder region)	0.496	0.504	0.000
E50.9 Vitamin A deficiency, unspecified	0.000	0.504	0.496
E50.8 Other manifestations of vitamin A deficiency	0.000	0.504	0.496
E50.7 Other ocular manifestations of vitamin A deficiency	0.000	0.504	0.496
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea	0.000	0.504	0.496
E50.5 Vitamin A deficiency with night blindness	0.000	0.504	0.496
E50.4 Vitamin A deficiency with keratomalacia	0.000	0.504	0.496
E50.3 Vitamin A deficiency with corneal ulceration and xerosis	0.000	0.504	0.496
E50.2 Vitamin A deficiency with corneal xerosis	0.000	0.504	0.496
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis	0.000	0.504	0.496
E50.0 Vitamin A deficiency with conjunctival xerosis	0.000	0.504	0.496
E63.9 Nutritional deficiency, unspecified	0.000	0.504	0.496
E63.8 Other specified nutritional deficiencies	0.000	0.504	0.496
E63.1 Imbalance of constituents of food intake	0.000	0.504	0.496
E63.0 Essential fatty acid [EFA] deficiency	0.000	0.504	0.496
E64.9 Sequelae of unspecified nutritional deficiency	0.000	0.504	0.496
E64.8 Sequelae of other nutritional deficiencies	0.000	0.504	0.496
E64.3 Sequelae of rickets	0.000	0.504	0.496
E64.2 Sequelae of vitamin C deficiency	0.000	0.504	0.496
E64.1 Sequelae of vitamin A deficiency	0.000	0.504	0.496
E64.0 Sequelae of protein-energy malnutrition	0.000	0.504	0.496
E56.9 Vitamin deficiency, unspecified	0.000	0.510	0.490
E56.8 Deficiency of other vitamins	0.000	0.510	0.490
E56.0 Deficiency of vitamin E	0.000	0.510	0.490
M06.30 Rheumatoid nodule (Multiple sites)	0.489	0.511	0.000
M05.97 Seropositive rheumatoid arthritis, unspecified (Ankle and foot)	0.486	0.514	0.000
E35 Disorders of endocrine glands in diseases classified elsewhere	0.000	0.515	0.485
E32 Diseases of thymus	0.000	0.515	0.485
E30 Disorders of puberty, not elsewhere classified	0.000	0.515	0.485
M06.39 Rheumatoid nodule (Site unspecified)	0.484	0.516	0.000
M06.38 Rheumatoid nodule (Other)	0.484	0.516	0.000
M06.35 Rheumatoid nodule (Pelvic region and thigh)	0.484	0.516	0.000
M06.31 Rheumatoid nodule (Shoulder region)	0.484	0.516	0.000
M05.92 Seropositive rheumatoid arthritis, unspecified (Upper arm)	0.484	0.516	0.000
M06.09 Seronegative rheumatoid arthritis (Site unspecified)	0.483	0.517	0.000
E56.1 Deficiency of vitamin K	0.000	0.518	0.482
E27.5 Adrenomedullary hyperfunction	0.000	0.518	0.482
E27.0 Other adrenocortical overactivity	0.000	0.518	0.482
D89.8 Other specified disorders involving the immune mechanism, not elsewhere classified	0.000	0.519	0.481
E27.3 Drug-induced adrenocortical insufficiency	0.000	0.521	0.479
M08 Juvenile arthritis	0.477	0.523	0.000
M06.37 Rheumatoid nodule (Ankle and foot)	0.476	0.524	0.000
E34 Other endocrine disorders	0.000	0.525	0.475
M06.05 Seronegative rheumatoid arthritis (Pelvic region and thigh)	0.473	0.527	0.000
M06.08 Seronegative rheumatoid arthritis (Other)	0.470	0.530	0.000
M06.04 Seronegative rheumatoid arthritis (Hand)	0.470	0.530	0.000
M06.03 Seronegative rheumatoid arthritis (Forearm)	0.470	0.530	0.000
M06.02 Seronegative rheumatoid arthritis (Upper arm)	0.470	0.530	0.000
E28 Ovarian dysfunction	0.000	0.533	0.467
D82.1 Di George's syndrome	0.000	0.533	0.467
M06.8 Other specified rheumatoid arthritis	0.465	0.535	0.000
E16.1 Other hypoglycaemia	0.001	0.535	0.464
M14 Arthropathies in other diseases classified elsewhere	0.464	0.536	0.000
M05.98 Seropositive rheumatoid arthritis, unspecified (Other)	0.458	0.542	0.000
E13.8 With unspecified complications	0.000	0.542	0.458
E13.7 With multiple complications	0.000	0.542	0.458
E13.6 With other specified complications	0.000	0.542	0.458
E13.5 With peripheral circulatory complications	0.000	0.542	0.458
E13.4 With neurological complications	0.000	0.542	0.458
E13.2 With renal complications	0.000	0.542	0.458
E13.1 With ketoacidosis	0.000	0.542	0.458
E13.0 With coma	0.000	0.542	0.458
M05.3 Rheumatoid arthritis with involvement of other organs and systems	0.457	0.543	0.000
M05.0 Felty's syndrome	0.457	0.543	0.000
M09 Juvenile arthritis in diseases classified elsewhere	0.455	0.545	0.000
E06.5 Other chronic thyroiditis	0.000	0.547	0.453
D84 Other immunodeficiencies	0.000	0.549	0.451
M06.91 Rheumatoid arthritis, unspecified (Shoulder region)	0.450	0.550	0.000
L42 Pityriasis rosea	0.432	0.554	0.014
K90.8 Other intestinal malabsorption	0.000	0.556	0.443
M11 Other crystal arthropathies	0.443	0.557	0.000
D89.1 Cryoglobulinaemia	0.000	0.564	0.436
M05.2 Rheumatoid vasculitis	0.433	0.567	0.000
E20.9 Hypoparathyroidism, unspecified	0.000	0.567	0.433
E13.9 Without complications	0.000	0.572	0.428
E06.4 Drug-induced thyroiditis	0.000	0.573	0.427
E06.2 Chronic thyroiditis with transient thyrotoxicosis	0.000	0.573	0.427
E06.0 Acute thyroiditis	0.000	0.573	0.427
E06.1 Subacute thyroiditis	0.000	0.574	0.425
C21.0 Anus, unspecified	0.424	0.576	0.000
D82.9 Immunodeficiency associated with major defect, unspecified	0.000	0.578	0.422
D82.8 Immunodeficiency associated with other specified major defects	0.000	0.578	0.422
D82.4 Hyperimmunoglobulin E [IgE] syndrome	0.000	0.578	0.422
D82.3 Immunodeficiency following hereditary defective response to Epstein-Barr virus	0.000	0.578	0.422
D82.2 Immunodeficiency with short-limbed stature	0.000	0.578	0.422
D82.0 Wiskott-Aldrich syndrome	0.000	0.578	0.422
E06.9 Thyroiditis, unspecified	0.000	0.578	0.422
M06.96 Rheumatoid arthritis, unspecified (Lower leg)	0.420	0.580	0.000
D80.1 Nonfamilial hypogammaglobulinaemia	0.000	0.582	0.418
E13.3 With ophthalmic complications	0.000	0.584	0.416
C21.1 Anal canal	0.416	0.584	0.000
L44 Other papulosquamous disorders	0.396	0.585	0.019
E04.2 Non-toxic multinodular goitre	0.000	0.586	0.414
M06.92 Rheumatoid arthritis, unspecified (Upper arm)	0.414	0.586	0.000
C21 Malignant neoplasm of anus and anal canal	0.414	0.586	0.000
E26 Hyperaldosteronism	0.000	0.589	0.411
E07.1 Dyshormogenetic goitre	0.000	0.591	0.409
E07.0 Hypersecretion of calcitonin	0.000	0.591	0.409
E25 Adrenogenital disorders	0.000	0.593	0.407
E34.8 Other specified endocrine disorders	0.000	0.595	0.405
E24 Cushing's syndrome	0.000	0.596	0.404
H36.0 Diabetic retinopathy	0.000	0.597	0.403
E04.0 Non-toxic diffuse goitre	0.000	0.598	0.402
M05.19 Rheumatoid lung disease (Site unspecified)	0.400	0.600	0.000
M07 Psoriatic and enteropathic arthropathies	0.399	0.601	0.000
M06.97 Rheumatoid arthritis, unspecified (Ankle and foot)	0.396	0.604	0.000
E44.1 Mild protein-energy malnutrition	0.000	0.605	0.395
E44.0 Moderate protein-energy malnutrition	0.000	0.605	0.395
L41 Parapsoriasis	0.371	0.608	0.021
L45 Papulosquamous disorders in diseases classified elsewhere	0.371	0.608	0.021
D81.9 Combined immunodeficiency, unspecified	0.000	0.610	0.390
D81.8 Other combined immunodeficiencies	0.000	0.610	0.390
D81.7 Major histocompatibility complex class II deficiency	0.000	0.610	0.390
D81.6 Major histocompatibility complex class I deficiency	0.000	0.610	0.390
D81.5 Purine nucleoside phosphorylase [PNP] deficiency	0.000	0.610	0.390
D81.4 Nezelof's syndrome	0.000	0.610	0.390
D81.3 Adenosine deaminase [ADA] deficiency	0.000	0.610	0.390
D81.2 Severe combined immunodeficiency [SCID] with low or normal B-cell numbers	0.000	0.610	0.390
D81.1 Severe combined immunodeficiency [SCID] with low T- and B-cell numbers	0.000	0.610	0.390
D81.0 Severe combined immunodeficiency [SCID] with reticular dysgenesis	0.000	0.610	0.390
M06.49 Inflammatory polyarthropathy (Site unspecified)	0.389	0.611	0.000
E07.8 Other specified disorders of thyroid	0.000	0.612	0.388
D80.2 Selective deficiency of immunoglobulin A [IgA]	0.000	0.613	0.386
M05.80 Other seropositive rheumatoid arthritis (Multiple sites)	0.386	0.614	0.000
M06.46 Inflammatory polyarthropathy (Lower leg)	0.384	0.616	0.000
E20.8 Other hypoparathyroidism	0.000	0.617	0.383
E20.1 Pseudohypoparathyroidism	0.000	0.617	0.383
E20.0 Idiopathic hypoparathyroidism	0.000	0.617	0.383
E27.9 Disorder of adrenal gland, unspecified	0.000	0.619	0.381
D80.3 Selective deficiency of immunoglobulin G [IgG] subclasses	0.000	0.623	0.377
M12 Other specific arthropathies	0.376	0.624	0.000
E28.3 Primary ovarian failure	0.000	0.624	0.375
D80.8 Other immunodeficiencies with predominantly antibody defects	0.000	0.625	0.374
D80.7 Transient hypogammaglobulinaemia of infancy	0.000	0.625	0.374
D80.6 Antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinaemia	0.000	0.625	0.374
D80.5 Immunodeficiency with increased immunoglobulin M [IgM]	0.000	0.625	0.374
D80.0 Hereditary hypogammaglobulinaemia	0.000	0.625	0.374
M06.10 Adult-onset Still's disease (Multiple sites)	0.373	0.627	0.000
E04.8 Other specified non-toxic goitre	0.000	0.628	0.372
M05.89 Other seropositive rheumatoid arthritis (Site unspecified)	0.371	0.629	0.000
M06.19 Adult-onset Still's disease (Site unspecified)	0.371	0.629	0.000
M06.18 Adult-onset Still's disease (Other)	0.371	0.629	0.000
M06.17 Adult-onset Still's disease (Ankle and foot)	0.371	0.629	0.000
M06.16 Adult-onset Still's disease (Lower leg)	0.371	0.629	0.000
M06.15 Adult-onset Still's disease (Pelvic region and thigh)	0.371	0.629	0.000
M06.14 Adult-onset Still's disease (Hand)	0.371	0.629	0.000
M06.13 Adult-onset Still's disease (Forearm)	0.371	0.629	0.000
M06.12 Adult-onset Still's disease (Upper arm)	0.371	0.629	0.000
M06.11 Adult-onset Still's disease (Shoulder region)	0.371	0.629	0.000
M06.29 Rheumatoid bursitis (Site unspecified)	0.369	0.630	0.000
M06.28 Rheumatoid bursitis (Other)	0.369	0.630	0.000
M06.27 Rheumatoid bursitis (Ankle and foot)	0.369	0.630	0.000
M06.26 Rheumatoid bursitis (Lower leg)	0.369	0.630	0.000
M06.25 Rheumatoid bursitis (Pelvic region and thigh)	0.369	0.630	0.000
M06.24 Rheumatoid bursitis (Hand)	0.369	0.630	0.000
M06.23 Rheumatoid bursitis (Forearm)	0.369	0.630	0.000
M06.22 Rheumatoid bursitis (Upper arm)	0.369	0.630	0.000
M06.21 Rheumatoid bursitis (Shoulder region)	0.369	0.630	0.000
M06.20 Rheumatoid bursitis (Multiple sites)	0.369	0.630	0.000
E31.0 Autoimmune polyglandular failure	0.000	0.632	0.368
E61.1 Iron deficiency	0.000	0.632	0.368
D83.8 Other common variable immunodeficiencies	0.000	0.633	0.367
D83.2 Common variable immunodeficiency with autoantibodies to B- or T-cells	0.000	0.633	0.367
D83.1 Common variable immunodeficiency with predominant immunoregulatory T-cell disorders	0.000	0.633	0.367
D83.0 Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function	0.000	0.633	0.367
M06.48 Inflammatory polyarthropathy (Other)	0.366	0.634	0.000
M06.47 Inflammatory polyarthropathy (Ankle and foot)	0.366	0.634	0.000
M06.45 Inflammatory polyarthropathy (Pelvic region and thigh)	0.366	0.634	0.000
M06.44 Inflammatory polyarthropathy (Hand)	0.366	0.634	0.000
M06.43 Inflammatory polyarthropathy (Forearm)	0.366	0.634	0.000
M06.42 Inflammatory polyarthropathy (Upper arm)	0.366	0.634	0.000
M06.41 Inflammatory polyarthropathy (Shoulder region)	0.366	0.634	0.000
E23 Hypofunction and other disorders of pituitary gland	0.000	0.635	0.364
M08.0 Juvenile rheumatoid arthritis	0.363	0.637	0.000
M14.6 Neuropathic arthropathy	0.359	0.641	0.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	0.000	0.641	0.359
M05.18 Rheumatoid lung disease (Other)	0.358	0.642	0.000
M05.17 Rheumatoid lung disease (Ankle and foot)	0.358	0.642	0.000
M05.16 Rheumatoid lung disease (Lower leg)	0.358	0.642	0.000
M05.15 Rheumatoid lung disease (Pelvic region and thigh)	0.358	0.642	0.000
M05.14 Rheumatoid lung disease (Hand)	0.358	0.642	0.000
M05.13 Rheumatoid lung disease (Forearm)	0.358	0.642	0.000
M05.12 Rheumatoid lung disease (Upper arm)	0.358	0.642	0.000
M05.11 Rheumatoid lung disease (Shoulder region)	0.358	0.642	0.000
M05.10 Rheumatoid lung disease (Multiple sites)	0.358	0.642	0.000
M05.88 Other seropositive rheumatoid arthritis (Other)	0.357	0.643	0.000
M05.87 Other seropositive rheumatoid arthritis (Ankle and foot)	0.357	0.643	0.000
M05.86 Other seropositive rheumatoid arthritis (Lower leg)	0.357	0.643	0.000
M05.85 Other seropositive rheumatoid arthritis (Pelvic region and thigh)	0.357	0.643	0.000
M05.84 Other seropositive rheumatoid arthritis (Hand)	0.357	0.643	0.000
M05.83 Other seropositive rheumatoid arthritis (Forearm)	0.357	0.643	0.000
M05.82 Other seropositive rheumatoid arthritis (Upper arm)	0.357	0.643	0.000
M05.81 Other seropositive rheumatoid arthritis (Shoulder region)	0.357	0.643	0.000
E31.9 Polyglandular dysfunction, unspecified	0.000	0.644	0.356
E31.8 Other polyglandular dysfunction	0.000	0.644	0.356
E31.1 Polyglandular hyperfunction	0.000	0.644	0.356
E30.9 Disorder of puberty, unspecified	0.000	0.652	0.348
E30.8 Other disorders of puberty	0.000	0.652	0.348
E30.1 Precocious puberty	0.000	0.652	0.348
E30.0 Delayed puberty	0.000	0.652	0.348
E32.9 Disease of thymus, unspecified	0.000	0.652	0.348
E32.8 Other diseases of thymus	0.000	0.652	0.348
E32.1 Abscess of thymus	0.000	0.652	0.348
E32.0 Persistent hyperplasia of thymus	0.000	0.652	0.348
E35.8 Disorders of other endocrine glands in diseases classified elsewhere	0.000	0.652	0.348
E35.1 Disorders of adrenal glands in diseases classified elsewhere	0.000	0.652	0.348
E35.0 Disorders of thyroid gland in diseases classified elsewhere	0.000	0.652	0.348
M11.9 Crystal arthropathy, unspecified	0.346	0.653	0.000
M08.2 Juvenile arthritis with systemic onset	0.342	0.657	0.000
M08.9 Juvenile arthritis, unspecified	0.342	0.658	0.000
M08.8 Other juvenile arthritis	0.342	0.658	0.000
M08.4 Pauciarticular juvenile arthritis	0.342	0.658	0.000
M08.3 Juvenile polyarthritis (seronegative)	0.342	0.658	0.000
M08.1 Juvenile ankylosing spondylitis	0.342	0.658	0.000
D80.4 Selective deficiency of immunoglobulin M [IgM]	0.000	0.659	0.341
E34.5 Androgen resistance syndrome	0.000	0.659	0.341
E34.4 Constitutional tall stature	0.000	0.659	0.341
E34.2 Ectopic hormone secretion, not elsewhere classified	0.000	0.659	0.341
E34.1 Other hypersecretion of intestinal hormones	0.000	0.659	0.341
H36 Retinal disorders in diseases classified elsewhere	0.000	0.660	0.340
E29 Testicular dysfunction	0.000	0.662	0.337
M06.89 Other specified rheumatoid arthritis (Site unspecified)	0.336	0.664	0.000
E28.9 Ovarian dysfunction, unspecified	0.000	0.665	0.335
E28.8 Other ovarian dysfunction	0.000	0.665	0.335
E28.1 Androgen excess	0.000	0.665	0.335
E28.0 Oestrogen excess	0.000	0.665	0.335
E34.0 Carcinoid syndrome	0.000	0.665	0.335
D83.9 Common variable immunodeficiency, unspecified	0.000	0.665	0.334
M06.88 Other specified rheumatoid arthritis (Other)	0.333	0.666	0.000
M06.87 Other specified rheumatoid arthritis (Ankle and foot)	0.333	0.666	0.000
M06.86 Other specified rheumatoid arthritis (Lower leg)	0.333	0.666	0.000
M06.85 Other specified rheumatoid arthritis (Pelvic region and thigh)	0.333	0.666	0.000
M06.84 Other specified rheumatoid arthritis (Hand)	0.333	0.666	0.000
M06.83 Other specified rheumatoid arthritis (Forearm)	0.333	0.666	0.000
M06.82 Other specified rheumatoid arthritis (Upper arm)	0.333	0.666	0.000
M06.81 Other specified rheumatoid arthritis (Shoulder region)	0.333	0.666	0.000
M14.8 Arthropathies in other specified diseases classified elsewhere	0.332	0.667	0.000
M14.5 Arthropathies in other endocrine, nutritional and metabolic disorders	0.332	0.667	0.000
M14.4 Arthropathy in amyloidosis	0.332	0.667	0.000
M14.3 Lipoid dermatoarthritis	0.332	0.667	0.000
M14.1 Crystal arthropathy in other metabolic disorders	0.332	0.667	0.000
M14.0 Gouty arthropathy due to enzyme defects and other inherited disorders	0.332	0.667	0.000
L43 Lichen planus	0.319	0.669	0.011
E34.3 Short stature, not elsewhere classified	0.000	0.672	0.328
M05.09 Felty's syndrome (Site unspecified)	0.327	0.672	0.000
M05.08 Felty's syndrome (Other)	0.327	0.672	0.000
M05.07 Felty's syndrome (Ankle and foot)	0.327	0.672	0.000
M05.06 Felty's syndrome (Lower leg)	0.327	0.672	0.000
M05.05 Felty's syndrome (Pelvic region and thigh)	0.327	0.672	0.000
M05.04 Felty's syndrome (Hand)	0.327	0.672	0.000
M05.03 Felty's syndrome (Forearm)	0.327	0.672	0.000
M05.02 Felty's syndrome (Upper arm)	0.327	0.672	0.000
M05.01 Felty's syndrome (Shoulder region)	0.327	0.672	0.000
M05.00 Felty's syndrome (Multiple sites)	0.327	0.672	0.000
M05.39 Rheumatoid arthritis with involvement of other organs and systems (Site unspecified)	0.327	0.672	0.000
M05.38 Rheumatoid arthritis with involvement of other organs and systems (Other)	0.327	0.672	0.000
M05.37 Rheumatoid arthritis with involvement of other organs and systems (Ankle and foot)	0.327	0.672	0.000
M05.36 Rheumatoid arthritis with involvement of other organs and systems (Lower leg)	0.327	0.672	0.000
M05.35 Rheumatoid arthritis with involvement of other organs and systems (Pelvic region and thigh)	0.327	0.672	0.000
M05.34 Rheumatoid arthritis with involvement of other organs and systems (Hand)	0.327	0.672	0.000
M05.33 Rheumatoid arthritis with involvement of other organs and systems (Forearm)	0.327	0.672	0.000
M05.32 Rheumatoid arthritis with involvement of other organs and systems (Upper arm)	0.327	0.672	0.000
M05.31 Rheumatoid arthritis with involvement of other organs and systems (Shoulder region)	0.327	0.672	0.000
M05.30 Rheumatoid arthritis with involvement of other organs and systems (Multiple sites)	0.327	0.672	0.000
M09.8 Juvenile arthritis in other diseases classified elsewhere	0.326	0.674	0.000
M09.2 Juvenile arthritis in ulcerative colitis	0.326	0.674	0.000
M09.1 Juvenile arthritis in Crohn's disease [regional enteritis]	0.326	0.674	0.000
M09.0 Juvenile arthritis in psoriasis	0.326	0.674	0.000
D84.0 Lymphocyte function antigen-1 [LFA-1] defect	0.000	0.676	0.323
D84.8 Other specified immunodeficiencies	0.000	0.679	0.321
L44.0 Pityriasis rubra pilaris	0.308	0.680	0.012
M11.1 Familial chondrocalcinosis	0.318	0.682	0.000
M11.0 Hydroxyapatite deposition disease	0.318	0.682	0.000
D84.1 Defects in the complement system	0.000	0.683	0.317
C21.8 Overlapping lesion of rectum, anus and anal canal	0.314	0.686	0.000
M05.28 Rheumatoid vasculitis (Other)	0.310	0.690	0.000
M05.27 Rheumatoid vasculitis (Ankle and foot)	0.310	0.690	0.000
M05.26 Rheumatoid vasculitis (Lower leg)	0.310	0.690	0.000
M05.25 Rheumatoid vasculitis (Pelvic region and thigh)	0.310	0.690	0.000
M05.24 Rheumatoid vasculitis (Hand)	0.310	0.690	0.000
M05.23 Rheumatoid vasculitis (Forearm)	0.310	0.690	0.000
M05.22 Rheumatoid vasculitis (Upper arm)	0.310	0.690	0.000
M05.21 Rheumatoid vasculitis (Shoulder region)	0.310	0.690	0.000
M14.2 Diabetic arthropathy	0.310	0.690	0.000
M06.40 Inflammatory polyarthropathy (Multiple sites)	0.310	0.690	0.000
D80.9 Immunodeficiency with predominantly antibody defects, unspecified	0.000	0.694	0.305
E65-E68 Obesity and other hyperalimentation	0.000	0.697	0.303
M11.8 Other specified crystal arthropathies	0.302	0.698	0.000
M05.29 Rheumatoid vasculitis (Site unspecified)	0.299	0.701	0.000
M05.20 Rheumatoid vasculitis (Multiple sites)	0.298	0.701	0.000
E07.9 Disorder of thyroid, unspecified	0.000	0.701	0.298
L44.9 Papulosquamous disorder, unspecified	0.284	0.702	0.014
L44.8 Other specified papulosquamous disorders	0.284	0.702	0.014
L44.4 Infantile papular acrodermatitis [Giannotti-Crosti]	0.284	0.702	0.014
L44.3 Lichen ruber moniliformis	0.284	0.702	0.014
L44.2 Lichen striatus	0.284	0.702	0.014
L44.1 Lichen nitidus	0.284	0.702	0.014
D50-D53 Nutritional anaemias	0.000	0.702	0.298
H04 Disorders of lachrymal system	0.000	0.703	0.297
C21.2 Cloacogenic zone	0.297	0.703	0.000
H00-H06 Disorders of eyelid, lacrimal system and orbit	0.000	0.703	0.297

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations