TreeWAS – Variant ID: rs2396545

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	Risk posterior probability	No effect posterior probability	Protective posterior probability
E03.9 Hypothyroidism, unspecified	0.000	0.026	0.974
E03 Other hypothyroidism	0.000	0.705	0.295
E03.5 Myxoedema coma	0.000	0.788	0.211
E03.4 Atrophy of thyroid (acquired)	0.000	0.788	0.211
E03.3 Postinfectious hypothyroidism	0.000	0.788	0.211
E03.8 Other specified hypothyroidism	0.000	0.792	0.208
E03.1 Congenital hypothyroidism without goitre	0.000	0.800	0.200
E03.0 Congenital hypothyroidism with diffuse goitre	0.000	0.807	0.192
E03.2 Hypothyroidism due to medicaments and other exogenous substances	0.000	0.848	0.152
E00-E07 Disorders of thyroid gland	0.000	0.903	0.097
E07 Other disorders of thyroid	0.000	0.914	0.086
E07.9 Disorder of thyroid, unspecified	0.000	0.920	0.080
E02 Subclinical iodine-deficiency hypothyroidism	0.000	0.929	0.070
E06 Thyroiditis	0.000	0.930	0.070
E01 Iodine-deficiency-related thyroid disorders and allied conditions	0.000	0.930	0.070
E00 Congenital iodine-deficiency syndrome	0.000	0.930	0.070
E07.1 Dyshormogenetic goitre	0.000	0.938	0.062
E07.0 Hypersecretion of calcitonin	0.000	0.938	0.062
E07.8 Other specified disorders of thyroid	0.000	0.942	0.058
E06.3 Autoimmune thyroiditis	0.000	0.943	0.057
E06.4 Drug-induced thyroiditis	0.000	0.949	0.050
E06.2 Chronic thyroiditis with transient thyrotoxicosis	0.000	0.949	0.050
E06.1 Subacute thyroiditis	0.000	0.949	0.050
E06.0 Acute thyroiditis	0.000	0.949	0.050
E00.9 Congenital iodine-deficiency syndrome, unspecified	0.000	0.950	0.050
E00.2 Congenital iodine-deficiency syndrome, mixed type	0.000	0.950	0.050
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type	0.000	0.950	0.050
E00.0 Congenital iodine-deficiency syndrome, neurological type	0.000	0.950	0.050
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions	0.000	0.950	0.050
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified	0.000	0.950	0.050
E01.1 Iodine-deficiency-related multinodular (endemic) goitre	0.000	0.950	0.050
E01.0 Iodine-deficiency-related diffuse (endemic) goitre	0.000	0.950	0.050
E06.9 Thyroiditis, unspecified	0.000	0.952	0.048
E06.5 Other chronic thyroiditis	0.000	0.955	0.045
E04 Other non-toxic goitre	0.000	0.955	0.045
E05 Thyrotoxicosis [hyperthyroidism]	0.000	0.958	0.042
N95.8 Other specified menopausal and perimenopausal disorders	0.038	0.962	0.000
E04.0 Non-toxic diffuse goitre	0.000	0.963	0.037
S01.9 Open wound of head, part unspecified	0.034	0.966	0.000
E05.2 Thyrotoxicosis with toxic multinodular goitre	0.000	0.967	0.033
E04.8 Other specified non-toxic goitre	0.000	0.968	0.032
E05.5 Thyroid crisis or storm	0.000	0.969	0.030
E05.4 Thyrotoxicosis factitia	0.000	0.969	0.030
E05.3 Thyrotoxicosis from ectopic thyroid tissue	0.000	0.969	0.030
E05.1 Thyrotoxicosis with toxic single thyroid nodule	0.000	0.969	0.030
E04.9 Non-toxic goitre, unspecified	0.000	0.969	0.031
E05.8 Other thyrotoxicosis	0.000	0.971	0.029
E05.9 Thyrotoxicosis, unspecified	0.000	0.974	0.026
S64 Injury of nerves at wrist and hand level	0.026	0.974	0.000
E04.1 Non-toxic single thyroid nodule	0.000	0.974	0.026
S64.0 Injury of ulnar nerve at wrist and hand level	0.026	0.974	0.000
S64.2 Injury of radial nerve at wrist and hand level	0.025	0.975	0.000
S64.4 Injury of digital nerve of other finger	0.023	0.977	0.000
Z02.8 Other examinations for administrative purposes	0.000	0.979	0.021
S64.3 Injury of digital nerve of thumb	0.021	0.979	0.000
S64.9 Injury of unspecified nerve at wrist and hand level	0.019	0.981	0.000
S64.8 Injury of other nerves at wrist and hand level	0.019	0.981	0.000
S64.7 Injury of multiple nerves at wrist and hand level	0.019	0.981	0.000
S64.1 Injury of median nerve at wrist and hand level	0.019	0.981	0.000
S68.1 Traumatic amputation of other single finger (complete)(partial)	0.015	0.985	0.000
S68 Traumatic amputation of wrist and hand	0.015	0.985	0.000
S60-S69 Injuries to the wrist and hand	0.015	0.985	0.000
S68.0 Traumatic amputation of thumb (complete)(partial)	0.013	0.987	0.000
S62 Fracture at wrist and hand level	0.013	0.987	0.000
S65 Injury of blood vessels at wrist and hand level	0.012	0.988	0.000
K08.8 Other specified disorders of teeth and supporting structures	0.012	0.988	0.000
S62.60 Fracture of other finger (closed)	0.012	0.988	0.000
S68.9 Traumatic amputation of wrist and hand, level unspecified	0.011	0.989	0.000
S68.8 Traumatic amputation of other parts of wrist and hand	0.011	0.989	0.000
S68.4 Traumatic amputation of hand at wrist level	0.011	0.989	0.000
S68.3 Combined traumatic amputation of (part of) finger(s) with other parts of wrist and hand	0.011	0.989	0.000
S63 Dislocation, sprain and strain of joints and ligaments at wrist and hand level	0.011	0.989	0.000
S62.7 Multiple fractures of fingers	0.011	0.989	0.000
S62.6 Fracture of other finger	0.011	0.989	0.000
S68.2 Traumatic amputation of two or more fingers alone (complete)(partial)	0.011	0.989	0.000
S65.1 Injury of radial artery at wrist and hand level	0.011	0.989	0.000
E04.2 Non-toxic multinodular goitre	0.000	0.989	0.011
H72.8 Other perforations of tympanic membrane	0.000	0.989	0.011
E05.0 Thyrotoxicosis with diffuse goitre	0.000	0.990	0.010
S67 Crushing injury of wrist and hand	0.010	0.990	0.000
S65.0 Injury of ulnar artery at wrist and hand level	0.010	0.990	0.000
S62.5 Fracture of thumb	0.010	0.990	0.000
S62.70 Multiple fractures of fingers (closed)	0.010	0.990	0.000
S62.1 Fracture of other carpal bone(s)	0.010	0.990	0.000
H74 Other disorders of middle ear and mastoid	0.000	0.991	0.009
S63.4 Traumatic rupture of ligament of finger at metacarpophalangeal and interphalangeal joint(s)	0.009	0.991	0.000
S65.9 Injury of unspecified blood vessel at wrist and hand level	0.009	0.991	0.000
S65.8 Injury of other blood vessels at wrist and hand level	0.009	0.991	0.000
S65.7 Injury of multiple blood vessels at wrist and hand level	0.009	0.991	0.000
S65.4 Injury of blood vessel(s) of thumb	0.009	0.991	0.000
S65.3 Injury of deep palmar arch	0.009	0.991	0.000
S65.2 Injury of superficial palmar arch	0.009	0.991	0.000
S62.51 Fracture of thumb (open)	0.009	0.991	0.000
S60 Superficial injury of wrist and hand	0.009	0.991	0.000
S62.8 Fracture of other and unspecified parts of wrist and hand	0.009	0.991	0.000
H72 Perforation of tympanic membrane	0.000	0.991	0.009
Z02 Examination and encounter for administrative purposes	0.000	0.991	0.009
C44.5 Skin of trunk	0.009	0.991	0.000
H65-H75 Diseases of middle ear and mastoid	0.000	0.991	0.009
H74.3 Other acquired abnormalities of ear ossicles	0.000	0.991	0.009
S63.3 Traumatic rupture of ligament of wrist and carpus	0.009	0.991	0.000
S62.71 Multiple fractures of fingers (open)	0.008	0.991	0.000
S62.3 Fracture of other metacarpal bone	0.008	0.991	0.000
H73 Other disorders of tympanic membrane	0.000	0.992	0.008
S62.4 Multiple fractures of metacarpal bones	0.008	0.992	0.000
S63.5 Sprain and strain of wrist	0.008	0.992	0.000
H74.8 Other specified disorders of middle ear and mastoid	0.000	0.992	0.008
S63.0 Dislocation of wrist	0.008	0.992	0.000
S62.2 Fracture of first metacarpal bone	0.008	0.992	0.000
H66.3 Other chronic suppurative otitis media	0.000	0.992	0.008
S63.1 Dislocation finger	0.008	0.992	0.000
S63.7 Sprain and strain of other and unspecified parts of hand	0.008	0.992	0.000
S63.2 Multiple dislocations of fingers	0.008	0.992	0.000
S60.2 Contusion of other parts of wrist and hand	0.008	0.992	0.000
S62.0 Fracture of navicular [scaphoid] bone of hand	0.008	0.992	0.000
S67.0 Crushing injury of thumb and other finger(s)	0.008	0.992	0.000
C44.2 Skin of ear and external auricular canal	0.008	0.992	0.000
H66 Suppurative and unspecified otitis media	0.000	0.992	0.008
H72.2 Other marginal perforations of tympanic membrane	0.000	0.992	0.008
H73.8 Other specified disorders of tympanic membrane	0.000	0.992	0.008
S82.30 Fracture of lower end of tibia (closed)	0.000	0.992	0.008
S62.10 Fracture of other carpal bone(s) (closed)	0.007	0.992	0.000
H74.4 Polyp of middle ear	0.000	0.992	0.007
S60.1 Contusion of finger(s) with damage to nail	0.007	0.992	0.000
S66 Injury of muscle and tendon at wrist and hand level	0.007	0.992	0.000
H61.3 Acquired stenosis of external ear canal	0.000	0.993	0.007
H74.9 Disorder of middle ear and mastoid, unspecified	0.000	0.993	0.007
H61.2 Impacted cerumen	0.000	0.993	0.007
H73.9 Disorder of tympanic membrane, unspecified	0.000	0.993	0.007
H74.0 Tympanosclerosis	0.000	0.993	0.007
S65.5 Injury of blood vessel(s) of other finger	0.007	0.993	0.000
S62.11 Fracture of other carpal bone(s) (open)	0.007	0.993	0.000
S67.8 Crushing injury of other and unspecified parts of wrist and hand	0.007	0.993	0.000
H74.2 Discontinuity and dislocation of ear ossicles	0.000	0.993	0.007
H74.1 Adhesive middle ear disease	0.000	0.993	0.007
S82.10 Fracture of upper end of tibia (closed)	0.000	0.993	0.007
S69 Other and unspecified injuries of wrist and hand	0.007	0.993	0.000
S62.81 Fracture of other and unspecified parts of wrist and hand (open)	0.007	0.993	0.000
H61 Other disorders of external ear	0.000	0.993	0.007
S66.9 Injury of unspecified muscle and tendon at wrist and hand level	0.007	0.993	0.000
S60.7 Multiple superficial injuries of wrist and hand	0.006	0.993	0.000
Z02.9 Examination for administrative purposes, unspecified	0.000	0.993	0.006
Z02.7 Issue of medical certificate	0.000	0.993	0.006
Z02.6 Examination for insurance purposes	0.000	0.993	0.006
Z02.5 Examination for participation in sport	0.000	0.993	0.006
Z02.4 Examination for driving licence	0.000	0.993	0.006
Z02.3 Examination for recruitment to armed forces	0.000	0.993	0.006
Z02.2 Examination for admission to residential institution	0.000	0.993	0.006
Z02.1 Pre-employment examination	0.000	0.993	0.006
Z02.0 Examination for admission to educational institution	0.000	0.993	0.006
H71 Cholesteatoma of middle ear	0.000	0.993	0.007
H66.1 Chronic tubotympanic suppurative otitis media	0.000	0.993	0.006
H75 Other disorders of middle ear and mastoid in diseases classified elsewhere	0.000	0.993	0.006
H67 Otitis media in diseases classified elsewhere	0.000	0.993	0.006
S63.6 Sprain and strain of finger(s)	0.006	0.994	0.000
S62.80 Fracture of other and unspecified parts of wrist and hand (closed)	0.006	0.994	0.000
S62.31 Fracture of other metacarpal bone (open)	0.006	0.994	0.000
H72.1 Attic perforation of tympanic membrane	0.000	0.994	0.006
H04.1 Other disorders of lachrymal gland	0.000	0.994	0.006
H73.1 Chronic myringitis	0.000	0.994	0.006
H73.0 Acute myringitis	0.000	0.994	0.006
S62.41 Multiple fractures of metacarpal bones (open)	0.006	0.994	0.000
S62.21 Fracture of first metacarpal bone (open)	0.006	0.994	0.000
S63.11 Subluxation and dislocation of metacarpophalangeal joint of thumb	0.006	0.994	0.000
S66.6 Injury of multiple flexor muscles and tendons at wrist and hand level	0.006	0.994	0.000
S62.50 Fracture of thumb (closed)	0.006	0.994	0.000
S62.01 Fracture of navicular [scaphoid] bone of hand (open)	0.006	0.994	0.000
H61.9 Disorder of external ear, unspecified	0.000	0.994	0.006
H66.4 Suppurative otitis media, unspecified	0.000	0.994	0.006
H68 Eustachian salpingitis and obstruction	0.000	0.994	0.006
S02.10 Fracture of base of skull (closed)	0.006	0.994	0.000
S60.0 Contusion of finger(s) without damage to nail	0.006	0.994	0.000
H70 Mastoiditis and related conditions	0.000	0.994	0.006
H72.0 Central perforation of tympanic membrane	0.000	0.994	0.006
S66.2 Injury of extensor muscle and tendon of thumb at wrist and hand level	0.006	0.994	0.000
S66.1 Injury of flexor muscle and tendon of other finger at wrist and hand level	0.006	0.994	0.000
S82.1 Fracture of upper end of tibia	0.000	0.994	0.006
S66.5 Injury of intrinsic muscle and tendon of other finger at wrist and hand level	0.006	0.994	0.000
S66.4 Injury of intrinsic muscle and tendon of thumb at wrist and hand level	0.006	0.994	0.000
S80.0 Contusion of knee	0.000	0.994	0.006
S86.8 Injury of other muscles and tendons at lower leg level	0.000	0.994	0.006
S86 Injury of muscle and tendon at lower leg level	0.000	0.994	0.005
H66.0 Acute suppurative otitis media	0.000	0.995	0.005
S62.30 Fracture of other metacarpal bone (closed)	0.005	0.995	0.000
S66.7 Injury of multiple extensor muscles and tendons at wrist and hand level	0.005	0.995	0.000
S82.3 Fracture of lower end of tibia	0.000	0.995	0.005
H69 Other disorders of Eustachian tube	0.000	0.995	0.005
C44.3 Skin of other and unspecified parts of face	0.005	0.995	0.000
S62.40 Multiple fractures of metacarpal bones (closed)	0.005	0.995	0.000
S69.9 Unspecified injury of wrist and hand	0.005	0.995	0.000
S86.9 Injury of unspecified muscle and tendon at lower leg level	0.000	0.995	0.005
C44 Other malignant neoplasms of skin	0.005	0.995	0.000
S80 Superficial injury of lower leg	0.000	0.995	0.005
S62.20 Fracture of first metacarpal bone (closed)	0.005	0.995	0.000
H61.1 Non-infective disorders of pinna	0.000	0.995	0.005
H66.2 Chronic atticoantral suppurative otitis media	0.000	0.995	0.005
S60.8 Other superficial injuries of wrist and hand	0.005	0.995	0.000
S66.0 Injury of long flexor muscle and tendon of thumb at wrist and hand level	0.005	0.995	0.000
H67.8 Otitis media in other diseases classified elsewhere	0.000	0.995	0.005
H67.1 Otitis media in viral diseases classified elsewhere	0.000	0.995	0.005
H67.0 Otitis media in bacterial diseases classified elsewhere	0.000	0.995	0.005
H75.8 Other specified disorders of middle ear and mastoid in diseases classified elsewhere	0.000	0.995	0.005
H75.0 Mastoiditis in infectious and parasitic diseases classified elsewhere	0.000	0.995	0.005
H60-H62 Diseases of external ear	0.000	0.995	0.005
S80-S89 Injuries to the knee and lower leg	0.000	0.995	0.005
S62.00 Fracture of navicular [scaphoid] bone of hand (closed)	0.005	0.995	0.000
H66.9 Otitis media, unspecified	0.000	0.995	0.005
S80.7 Multiple superficial injuries of lower leg	0.000	0.995	0.005
S82 Fracture of lower leg, including ankle	0.000	0.995	0.005
Z88.9 Personal history of allergy to unspecified drugs, medicaments and biological substances	0.005	0.995	0.000
C44.9 Malignant neoplasm of skin, unspecified	0.005	0.995	0.000
H70.1 Chronic mastoiditis	0.000	0.995	0.005
S02.1 Fracture of base of skull	0.005	0.995	0.000
H70.8 Other mastoiditis and related conditions	0.000	0.995	0.004
H68.0 Eustachian salpingitis	0.000	0.995	0.004
H70.2 Petrositis	0.000	0.995	0.004
H70.0 Acute mastoiditis	0.000	0.995	0.004
I49.8 Other specified cardiac arrhythmias	0.004	0.996	0.000
S86.1 Injury of other muscle(s) and tendon(s) of posterior muscle group at lower leg level	0.000	0.996	0.004
H90.1 Conductive hearing loss, unilateral with unrestricted hearing on the contralateral side	0.000	0.996	0.004
S60.9 Superficial injury of wrist and hand, unspecified	0.004	0.996	0.000
C44.6 Skin of upper limb, including shoulder	0.004	0.996	0.000
S80.1 Contusion of other and unspecified parts of lower leg	0.000	0.996	0.004
Chapter VIII Diseases of the ear and mastoid process	0.000	0.996	0.004
S83.5 Sprain and strain involving (anterior)(posterior) cruciate ligament of knee	0.000	0.996	0.004
S83 Dislocation, sprain and strain of joints and ligaments of knee	0.000	0.996	0.004
S86.2 Injury of muscle(s) and tendon(s) of anterior muscle group at lower leg level	0.000	0.996	0.004
S86.0 Injury of Achilles tendon	0.000	0.996	0.004
S86.7 Injury of multiple muscles and tendons at lower leg level	0.000	0.996	0.004
M07.39 Other psoriatic arthropathies (Site unspecified)	0.000	0.996	0.004
H69.0 Patulous Eustachian tube	0.000	0.996	0.004
S82.11 Fracture of upper end of tibia (open)	0.000	0.996	0.004
S82.6 Fracture of lateral malleolus	0.000	0.996	0.004
S69.8 Other specified injuries of wrist and hand	0.004	0.996	0.001
S66.8 Injury of other muscles and tendons at wrist and hand level	0.004	0.996	0.000
C44.8 Overlapping lesion of skin	0.004	0.996	0.000
H68.1 Obstruction of Eustachian tube	0.000	0.996	0.004
H69.9 Eustachian tube disorder, unspecified	0.000	0.996	0.004
H72.9 Perforation of tympanic membrane, unspecified	0.000	0.996	0.004
S83.4 Sprain and strain involving (fibular)(tibial) collateral ligamnent of knee	0.000	0.996	0.004
S89 Other and unspecified injuries of lower leg	0.000	0.996	0.004
M07.30 Other psoriatic arthropathies (Multiple sites)	0.000	0.996	0.004
S61.0 Open wound of finger(s) without damage to nail	0.004	0.996	0.000
S69.7 Multiple injuries of wrist and hand	0.003	0.996	0.001
H62 Disorders of external ear in diseases classified elsewhere	0.000	0.996	0.004
S88 Traumatic amputation of lower leg	0.000	0.996	0.004
S87 Crushing injury of lower leg	0.000	0.996	0.004
S85 Injury of blood vessels at lower leg level	0.000	0.996	0.004
S84 Injury of nerves at lower leg level	0.000	0.996	0.004
S82.7 Multiple fractures of lower leg	0.000	0.996	0.004
B18.2 Chronic viral hepatitis C	0.004	0.996	0.000
H90 Conductive and sensorineural hearing loss	0.000	0.996	0.004
H18.5 Hereditary corneal dystrophies	0.000	0.996	0.004
H61.8 Other specified disorders of external ear	0.000	0.996	0.004
S80.8 Other superficial injuries of lower leg	0.000	0.996	0.004
H90.7 Mixed conductive and sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side	0.000	0.996	0.004
H90.0 Conductive hearing loss, bilateral	0.000	0.996	0.004
S82.0 Fracture of patella	0.000	0.996	0.004
H90.6 Mixed conductive and sensorineural hearing loss, bilateral	0.000	0.996	0.004
S82.9 Fracture of lower leg, part unspecified	0.000	0.996	0.003
S02 Fracture of skull and facial bones	0.004	0.996	0.000
S02.11 Fracture of base of skull (open)	0.003	0.996	0.000
S61 Open wound of wrist and hand	0.004	0.996	0.000
S82.60 Fracture of lateral malleolus (closed)	0.000	0.996	0.004
S86.3 Injury of muscle(s) and tendon(s) of peroneal muscle group at lower leg level	0.000	0.996	0.003
O66.5 Failed application of vacuum extractor and forceps, unspecified	0.000	0.996	0.003
S82.5 Fracture of medial malleolus	0.000	0.997	0.003
M07.3 Other psoriatic arthropathies	0.000	0.997	0.003
H70.9 Mastoiditis, unspecified	0.000	0.997	0.003
O03.4 Incomplete, without complication	0.000	0.997	0.003
S83.3 Tear of articular cartilage of knee, current	0.000	0.997	0.003
S83.1 Dislocation of knee	0.000	0.997	0.003
S83.0 Dislocation of patella	0.000	0.997	0.003
S02.4 Fracture of malar and maxillary bones	0.003	0.997	0.000
S86.00 Unspecified injury of Achilles tendon	0.000	0.997	0.003
S02.2 Fracture of nasal bones	0.003	0.997	0.000
M79.84 Other specified soft tissue disorders (Hand)	0.000	0.997	0.003
S82.61 Fracture of lateral malleolus (open)	0.000	0.997	0.003
E80.4 Gilbert's syndrome	0.003	0.997	0.000
S89.9 Unspecified injury of lower leg	0.000	0.997	0.003
S02.3 Fracture of orbital floor	0.003	0.997	0.000
S83.7 Injury to multiple structures of knee	0.000	0.997	0.003
H69.8 Other specified disorders of Eustachian tube	0.000	0.997	0.003
S02.40 Fracture of malar and maxillary bones (closed)	0.003	0.997	0.000
S02.7 Multiple fractures involving skull and facial bones	0.003	0.997	0.000
H61.0 Perichondritis of external ear	0.000	0.997	0.003
H90.8 Mixed conductive and sensorineural hearing loss, unspecified	0.000	0.997	0.003
S89.7 Multiple injuries of lower leg	0.000	0.997	0.003
S89.1 Other specified injuries of lower leg	0.000	0.997	0.003
S89.0 Multiple injuries of lower leg	0.000	0.997	0.003
S02.20 Fracture of nasal bones (closed)	0.003	0.997	0.000
S02.6 Fracture of mandible	0.003	0.997	0.000
S82.70 Multiple fractures of lower leg (closed)	0.000	0.997	0.003
H62.8 Other disorders of external ear in diseases classified elsewhere	0.000	0.997	0.003
H62.4 Otitis externa in other diseases classified elsewhere	0.000	0.997	0.003
H62.3 Otitis externa in other infectious and parasitic diseases classified elsewhere	0.000	0.997	0.003
H62.2 Otitis externa in mycoses	0.000	0.997	0.003
H62.1 Otitis externa in viral diseases classified elsewhere	0.000	0.997	0.003
H62.0 Otitis externa in bacterial diseases classified elsewhere	0.000	0.997	0.003
S84.9 Injury of unspecified nerve at lower leg level	0.000	0.997	0.003
S84.8 Injury of other nerves at lower leg level	0.000	0.997	0.003
S84.7 Injury of multiple nerves at lower leg level	0.000	0.997	0.003
S84.2 Injury of cutaneous sensory nerve at lower leg level	0.000	0.997	0.003
S84.1 Injury of peroneal nerve at lower leg level	0.000	0.997	0.003
S84.0 Injury of tibial nerve at lower leg level	0.000	0.997	0.003
S85.9 Injury of unspecified blood vessel at lower leg level	0.000	0.997	0.003
S85.8 Injury of other blood vessels at lower leg level	0.000	0.997	0.003
S85.7 Injury of multiple blood vessels at lower leg level	0.000	0.997	0.003
S85.5 Injury of popliteal vein	0.000	0.997	0.003
S85.4 Injury of lesser saphenous vein at lower leg level	0.000	0.997	0.003
S85.3 Injury of greater saphenous vein at lower leg level	0.000	0.997	0.003
S85.2 Injury of peroneal artery	0.000	0.997	0.003
S85.1 Injury of (anterior)(posterior) tibial artery	0.000	0.997	0.003
S85.0 Injury of popliteal artery	0.000	0.997	0.003
S87.8 Crushing injury of other and unspecified parts of lower leg	0.000	0.997	0.003
S87.0 Crushing injury of knee	0.000	0.997	0.003
S88.9 Traumatic amputation of lower leg, level unspecified	0.000	0.997	0.003
S88.1 Traumatic amputation at level between knee and ankle	0.000	0.997	0.003
S88.0 Traumatic amputation at knee level	0.000	0.997	0.003
S89.8 Other specified injuries of lower leg	0.000	0.997	0.003
S82.01 Fracture of patella (open)	0.000	0.997	0.003
S82.71 Multiple fractures of lower leg (open)	0.000	0.997	0.003
H65 Nonsuppurative otitis media	0.000	0.997	0.003
S02.30 Fracture of orbital floor (closed)	0.003	0.997	0.000
S83.6 Sprain and strain of other and unspecified parts of knee	0.000	0.997	0.003
S02.70 Multiple fractures involving skull and facial bones (closed)	0.003	0.997	0.000
S82.91 Fracture of lower leg, part unspecified (open)	0.000	0.997	0.003
H90.4 Sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side	0.000	0.997	0.003
S02.5 Fracture of tooth	0.003	0.997	0.000
S82.51 Fracture of medial malleolus (open)	0.000	0.997	0.003
H90-H95 Other disorders of ear	0.000	0.997	0.003
H90.3 Sensorineural hearing loss, bilateral	0.000	0.997	0.003
H60 Otitis externa	0.000	0.997	0.003
S02.21 Fracture of nasal bones (open)	0.003	0.997	0.000
S62.61 Fracture of other finger (open)	0.002	0.997	0.000
S82.90 Fracture of lower leg, part unspecified (closed)	0.000	0.997	0.002
S82.4 Fracture of fibula alone	0.000	0.997	0.002
M07.38 Other psoriatic arthropathies (Other)	0.000	0.997	0.003
M07.35 Other psoriatic arthropathies (Pelvic region and thigh)	0.000	0.997	0.003
M07.33 Other psoriatic arthropathies (Forearm)	0.000	0.997	0.003
M07.32 Other psoriatic arthropathies (Upper arm)	0.000	0.997	0.003
M07.31 Other psoriatic arthropathies (Shoulder region)	0.000	0.997	0.003
M07.34 Other psoriatic arthropathies (Hand)	0.000	0.997	0.003
S02.60 Fracture of mandible (closed)	0.003	0.997	0.000
H95.1 Other disorders following mastoidectomy	0.000	0.997	0.003
S02.41 Fracture of malar and maxillary bones (open)	0.002	0.997	0.000
B18 Chronic viral hepatitis	0.003	0.997	0.000
R01.1 Cardiac murmur, unspecified	0.000	0.997	0.003
S02.31 Fracture of orbital floor (open)	0.002	0.997	0.000
S82.00 Fracture of patella (closed)	0.000	0.997	0.003
S82.31 Fracture of lower end of tibia (open)	0.001	0.997	0.002
E46 Unspecified protein-energy malnutrition	0.000	0.997	0.003
H95 Postprocedural disorders of ear and mastoid process, not elsewhere classified	0.000	0.997	0.002
S02.71 Multiple fractures involving skull and facial bones (open)	0.002	0.997	0.000
S02.9 Fracture of skull and facial bones, part unspecified	0.002	0.997	0.000
S02.8 Fractures of other skull and facial bones	0.002	0.997	0.000
H65.0 Acute serous otitis media	0.000	0.997	0.002
M07.37 Other psoriatic arthropathies (Ankle and foot)	0.000	0.997	0.002
Q89.2 Congenital malformations of other endocrine glands	0.003	0.997	0.000
S02.61 Fracture of mandible (open)	0.002	0.998	0.000
H60.3 Other infective otitis externa	0.000	0.998	0.002
M19.90 Arthrosis, unspecified (Multiple sites)	0.000	0.998	0.002
S02.0 Fracture of vault of skull	0.002	0.998	0.000
B18.1 Chronic viral hepatitis B without delta-agent	0.002	0.998	0.000
S80.9 Superficial injury of lower leg, unspecified	0.000	0.998	0.002
M07.36 Other psoriatic arthropathies (Lower leg)	0.000	0.998	0.002
H65.4 Other chronic nonsuppurative otitis media	0.000	0.998	0.002
S02.51 Fracture of tooth (open)	0.002	0.998	0.000
S72.30 Fracture of shaft of femur (closed)	0.000	0.998	0.002
Q28.2 Arteriovenous malformation of cerebral vessels	0.002	0.998	0.000
H94 Other disorders of ear in diseases classified elsewhere	0.000	0.998	0.002
H60.0 Abscess of external ear	0.000	0.998	0.002
H65.2 Chronic serous otitis media	0.000	0.998	0.002
S02.50 Fracture of tooth (closed)	0.002	0.998	0.000
H60.2 Malignant otitis externa	0.000	0.998	0.002
H60.5 Acute otitis externa, non-infective	0.000	0.998	0.002
H60.1 Cellulitis of external ear	0.000	0.998	0.002
K10.8 Other specified diseases of jaws	0.002	0.998	0.000
S82.41 Fracture of fibula alone (open)	0.000	0.998	0.002
S82.50 Fracture of medial malleolus (closed)	0.000	0.998	0.002
S82.2 Fracture of shaft of tibia	0.000	0.998	0.002
N30.2 Other chronic cystitis	0.000	0.998	0.002
B18.9 Chronic viral hepatitis, unspecified	0.002	0.998	0.000
B18.8 Other chronic viral hepatitis	0.002	0.998	0.000
B18.0 Chronic viral hepatitis B with delta-agent	0.002	0.998	0.000
G95.0 Syringomyelia and syringobulbia	0.002	0.998	0.000
R41.2 Retrograde amnesia	0.002	0.998	0.000
H65.1 Other acute nonsuppurative otitis media	0.000	0.998	0.002
B96.3 Haemophilus influenzae [H. influenzae] as the cause of diseases classified to other chapters	0.000	0.998	0.002
G80.9 Infantile cerebral palsy, unspecified	0.002	0.998	0.000
H95.9 Postprocedural disorder of ear and mastoid process, unspecified	0.000	0.998	0.002
S81 Open wound of lower leg	0.000	0.998	0.002
S02.81 Fractures of other skull and facial bones (open)	0.002	0.998	0.000
S02.91 Fracture of skull and facial bones, part unspecified (open)	0.002	0.998	0.000
H18.6 Keratoconus	0.000	0.998	0.002
H43.8 Other disorders of vitreous body	0.000	0.998	0.002
H60.4 Cholesteatoma of external ear	0.000	0.998	0.002
H18.1 Bullous keratopathy	0.000	0.998	0.002
J15.7 Pneumonia due to Mycoplasma pneumoniae	0.000	0.998	0.002
J93.1 Other spontaneous pneumothorax	0.000	0.998	0.002
S82.8 Fractures of other parts of lower leg	0.000	0.998	0.002
S83.2 Tear of meniscus, current	0.000	0.998	0.002
H18 Other disorders of cornea	0.000	0.998	0.002
J93.9 Pneumothorax, unspecified	0.000	0.998	0.002
N30.1 Interstitial cystitis (chronic)	0.000	0.998	0.002
S02.01 Fracture of vault of skull (open)	0.002	0.998	0.000
H95.0 Recurrent cholesteatoma of postmastoidectomy cavity	0.000	0.998	0.002
J93.8 Other pneumothorax	0.000	0.998	0.002
R52.2 Other chronic pain	0.002	0.998	0.000
D32.9 Meninges, unspecified	0.002	0.998	0.000
H60.8 Other otitis externa	0.000	0.998	0.002
R06.2 Wheezing	0.002	0.998	0.000
C44.0 Skin of lip	0.002	0.998	0.000
M90.75 Fracture of bone in neoplastic disease (Pelvic region and thigh)	0.000	0.998	0.002
H94.8 Other specified disorders of ear in diseases classified elsewhere	0.000	0.998	0.002
H94.0 Acoustic neuritis in infectious and parasitic diseases classified elsewhere	0.000	0.998	0.002
H95.8 Other postprocedural disorders of ear and mastoid process	0.000	0.998	0.002
C43.6 Malignant melanoma of upper limb, including shoulder	0.000	0.998	0.002
Q28 Other congenital malformations of circulatory system	0.002	0.998	0.000
Q28.3 Other malformations of cerebral vessels	0.002	0.998	0.000
Q28.0 Arteriovenous malformation of precerebral vessels	0.002	0.998	0.000
E40-E46 Malnutrition	0.000	0.998	0.002
M79.19 Myalgia (Site unspecified)	0.000	0.998	0.002
C18.0 Caecum	0.000	0.998	0.002
J93 Pneumothorax	0.000	0.998	0.002
H18.0 Corneal pigmentations and deposits	0.000	0.998	0.002
M72.04 Palmar fascial fibromatosis [Dupuytren]-Hand	0.002	0.998	0.000
S02.90 Fracture of skull and facial bones, part unspecified (closed)	0.001	0.998	0.000
S72.40 Fracture of lower end of femur (closed)	0.000	0.998	0.002
W07.0 Home	0.002	0.998	0.000
M90.72 Fracture of bone in neoplastic disease (Upper arm)	0.000	0.998	0.002
O44.0 Placenta praevia specified as without haemorrhage	0.002	0.998	0.000
G95.8 Other specified diseases of spinal cord	0.002	0.998	0.000
S02.80 Fractures of other skull and facial bones (closed)	0.002	0.998	0.000
S82.86 Maisonneuve's fracture	0.000	0.998	0.002
H18.7 Other corneal deformities	0.000	0.998	0.002
H18.3 Changes in corneal membranes	0.000	0.998	0.002
B17.1 Acute hepatitis C	0.002	0.998	0.000
S81.0 Open wound of knee	0.000	0.998	0.002
S72.3 Fracture of shaft of femur	0.000	0.998	0.002
M90.7 Fracture of bone in neoplastic disease	0.000	0.998	0.002
L40.5 Arthropathic psoriasis	0.000	0.998	0.002
S61.7 Multiple open wounds of wrist and hand	0.001	0.998	0.000
H18.2 Other corneal oedema	0.000	0.998	0.002
M81.09 Postmenopausal osteoporosis (Site unspecified)	0.002	0.998	0.000
C79.7 Secondary malignant neoplasm of adrenal gland	0.000	0.998	0.002
N30.4 Irradiation cystitis	0.000	0.998	0.002
G35 Multiple sclerosis	0.000	0.998	0.002
D32.1 Spinal meninges	0.002	0.998	0.000
S61.9 Open wound of wrist and hand, part unspecified	0.002	0.998	0.000
M90.78 Fracture of bone in neoplastic disease (Other)	0.000	0.998	0.002
H83.0 Labyrinthitis	0.002	0.998	0.000
Q28.9 Congenital malformation of circulatory system, unspecified	0.001	0.998	0.000
Q28.8 Other specified congenital malformations of circulatory system	0.001	0.998	0.000
Q28.1 Other malformations of precerebral vessels	0.001	0.998	0.000
S81.8 Open wound of other parts of lower leg	0.000	0.998	0.002
E44 Protein-energy malnutrition of moderate and mild degree	0.000	0.998	0.001
E45 Retarded development following protein-energy malnutrition	0.000	0.998	0.001
E43 Unspecified severe protein-energy malnutrition	0.000	0.998	0.001
E42 Marasmic kwashiorkor	0.000	0.998	0.001
E41 Nutritional marasmus	0.000	0.998	0.001
E40 Kwashiorkor	0.000	0.998	0.001
N30 Cystitis	0.000	0.998	0.002
S82.81 Fractures of other parts of lower leg (open)	0.000	0.998	0.001
N30.8 Other cystitis	0.000	0.998	0.002
Z01.8 Other specified special examinations	0.002	0.998	0.000
E80 Disorders of porphyrin and bilirubin metabolism	0.002	0.998	0.000
B37.0 Candidal stomatitis	0.000	0.998	0.002
H90.2 Conductive hearing loss, unspecified	0.000	0.998	0.001
Q89 Other congenital malformations, not elsewhere classified	0.002	0.998	0.000
M23.29 Derangement of meniscus due to old tear or injury (Unspecified ligament or Unspecified meniscus)	0.002	0.998	0.000
G40.8 Other epilepsy	0.002	0.998	0.000
G96.1 Disorders of meninges, not elsewhere classified	0.002	0.998	0.000
H18.9 Disorder of cornea, unspecified	0.000	0.998	0.001
B17 Other acute viral hepatitis	0.001	0.998	0.000
H90.5 Sensorineural hearing loss, unspecified	0.000	0.998	0.001
I24.0 Coronary thrombosis not resulting in myocardial infarction	0.000	0.998	0.002
D32.0 Cerebral meninges	0.002	0.998	0.000
G95.1 Vascular myelopathies	0.001	0.998	0.000
L05.9 Pilonidal cyst without abscess	0.002	0.998	0.000
S72.31 Fracture of shaft of femur (open)	0.000	0.998	0.001
T44.7 Beta-Adrenoreceeptor antagonists, not elsewhere classified	0.000	0.998	0.001
M07 Psoriatic and enteropathic arthropathies	0.000	0.998	0.001
M90.79 Fracture of bone in neoplastic disease (Site unspecified)	0.000	0.998	0.001
M90.77 Fracture of bone in neoplastic disease (Ankle and foot)	0.000	0.998	0.001
M90.76 Fracture of bone in neoplastic disease (Lower leg)	0.000	0.998	0.001
M90.74 Fracture of bone in neoplastic disease (Hand)	0.000	0.998	0.001
M90.73 Fracture of bone in neoplastic disease (Forearm)	0.000	0.998	0.001
M90.71 Fracture of bone in neoplastic disease (Shoulder region)	0.000	0.998	0.001
M90.70 Fracture of bone in neoplastic disease (Multiple sites)	0.000	0.998	0.001
S02.00 Fracture of vault of skull (closed)	0.001	0.998	0.000
E80.2 Other porphyria	0.001	0.998	0.000
F81.9 Developmental disorder of scholastic skills, unspecified	0.001	0.998	0.000
G80.0 Spastic cerebral palsy	0.001	0.998	0.000
H65.9 Nonsuppurative otitis media, unspecified	0.000	0.998	0.001
S81.7 Multiple open wounds of lower leg	0.000	0.998	0.001
D32 Benign neoplasm of meninges	0.001	0.998	0.000
H92 Otalgia and effusion of ear	0.000	0.998	0.001
S82.21 Fracture of shaft of tibia (open)	0.000	0.999	0.001
S66.3 Injury of extensor muscle and tendon of other finger at wrist and hand level	0.001	0.999	0.001

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations