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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs2517451
log Bayes Factor = 39.0876
Chromosome 6   position 30,914,751  (GRCh37) Explore rs2517451 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E10.9 Without complications
0.000 0.000 1.000
E83.1 Disorders of iron metabolism
1.000 0.000 0.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
G35 Multiple sclerosis
1.000 0.000 0.000
E10-E14 Diabetes mellitus
0.000 0.000 1.000
L40.9 Psoriasis, unspecified
0.000 0.000 1.000
E11 Non-insulin-dependent diabetes mellitus
0.000 0.000 1.000
L40 Psoriasis
0.000 0.001 0.999
E11.9 Without complications
0.000 0.001 0.999
E78.0 Pure hypercholesterolaemia
0.000 0.001 0.999
E10.3 With ophthalmic complications
0.000 0.002 0.998
L40.5 Arthropathic psoriasis
0.000 0.002 0.998
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.000 0.007 0.993
K90.0 Coeliac disease
0.000 0.020 0.980
E14 Unspecified diabetes mellitus
0.000 0.021 0.979
G35-G37 Demyelinating diseases of the central nervous system
0.950 0.050 0.000
E78.5 Hyperlipidaemia, unspecified
0.000 0.050 0.950
I20-I25 Ischaemic heart diseases
0.000 0.053 0.947
E14.9 Without complications
0.000 0.054 0.946
I24 Other acute ischaemic heart diseases
0.000 0.056 0.944
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.057 0.942
E70-E90 Metabolic disorders
0.002 0.059 0.939
I25 Chronic ischaemic heart disease
0.000 0.064 0.936
E10.1 With ketoacidosis
0.000 0.066 0.934
E10.4 With neurological complications
0.000 0.068 0.932
I24.9 Acute ischaemic heart disease, unspecified
0.000 0.075 0.925
E11.5 With peripheral circulatory complications
0.000 0.078 0.922
I21 Acute myocardial infarction
0.000 0.086 0.914
E78.2 Mixed hyperlipidaemia
0.000 0.097 0.903
G37 Other demyelinating diseases of central nervous system
0.895 0.105 0.000
L40.0 Psoriasis vulgaris
0.000 0.107 0.893
I25.1 Atherosclerotic heart disease
0.000 0.108 0.892
E10.2 With renal complications
0.000 0.112 0.888
I25.2 Old myocardial infarction
0.000 0.112 0.888
E11.6 With other specified complications
0.000 0.117 0.883
I24.8 Other forms of acute ischaemic heart disease
0.000 0.118 0.882
I22 Subsequent myocardial infarction
0.000 0.125 0.875
I25.8 Other forms of chronic ischaemic heart disease
0.000 0.133 0.867
E11.4 With neurological complications
0.000 0.144 0.856
E14.3 With ophthalmic complications
0.000 0.146 0.854
I21.4 Acute subendocardial myocardial infarction
0.000 0.147 0.853
G37.9 Demyelinating disease of central nervous system, unspecified
0.845 0.155 0.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.159 0.841
I10-I15 Hypertensive diseases
0.000 0.164 0.836
I12 Hypertensive renal disease
0.000 0.164 0.836
I10 Essential (primary) hypertension
0.000 0.166 0.834
I21.9 Acute myocardial infarction, unspecified
0.000 0.169 0.831
I12.0 Hypertensive renal disease with renal failure
0.000 0.171 0.829
E11.0 With coma
0.000 0.174 0.826
I21.2 Acute transmural myocardial infarction of other sites
0.000 0.179 0.821
E13 Other specified diabetes mellitus
0.000 0.181 0.819
E11.1 With ketoacidosis
0.000 0.189 0.811
I22.1 Subsequent myocardial infarction of inferior wall
0.000 0.202 0.798
E11.2 With renal complications
0.000 0.203 0.797
E10.8 With unspecified complications
0.000 0.210 0.790
E10.5 With peripheral circulatory complications
0.000 0.213 0.787
I24.0 Coronary thrombosis not resulting in myocardial infarction
0.000 0.217 0.783
E78.1 Pure hyperglyceridaemia
0.000 0.222 0.778
Chapter VI Diseases of the nervous system
0.776 0.224 0.000
I12.9 Hypertensive renal disease without renal failure
0.000 0.224 0.776
E16 Other disorders of pancreatic internal secretion
0.000 0.231 0.769
E85 Amyloidosis
0.001 0.232 0.767
I25.5 Ischaemic cardiomyopathy
0.000 0.242 0.758
E10.6 With other specified complications
0.000 0.245 0.755
E78.8 Other disorders of lipoprotein metabolism
0.000 0.248 0.752
I22.9 Subsequent myocardial infarction of unspecified site
0.000 0.259 0.741
G00-G09 Inflammatory diseases of the central nervous system
0.738 0.262 0.000
E20-E35 Disorders of other endocrine glands
0.000 0.264 0.736
G37.8 Other specified demyelinating diseases of central nervous system
0.722 0.278 0.000
I23 Certain current complications following acute myocardial infarction
0.000 0.280 0.720
L40.8 Other psoriasis
0.000 0.280 0.720
E10.7 With multiple complications
0.000 0.283 0.717
E10.0 With coma
0.000 0.283 0.717
E12 Malnutrition-related diabetes mellitus
0.000 0.283 0.717
E11.7 With multiple complications
0.000 0.283 0.717
L40.4 Guttate psoriasis
0.000 0.284 0.716
L40.3 Pustulosis palmaris et plantaris
0.000 0.284 0.716
L40.2 Acrodermatitis continua
0.000 0.284 0.716
L40.1 Generalised pustular psoriasis
0.000 0.284 0.716
E78.6 Lipoprotein deficiency
0.000 0.288 0.712
E78.3 Hyperchylomicronaemia
0.000 0.288 0.712
G30-G32 Other degenerative diseases of the nervous system
0.710 0.290 0.000
E14.8 With unspecified complications
0.000 0.298 0.702
E14.7 With multiple complications
0.000 0.298 0.702
E14.6 With other specified complications
0.000 0.298 0.702
E14.5 With peripheral circulatory complications
0.000 0.298 0.702
E14.4 With neurological complications
0.000 0.298 0.702
E14.2 Withrenal complications
0.000 0.298 0.702
E14.1 With ketoacidosis
0.000 0.298 0.702
E14.0 With coma
0.000 0.298 0.702
E16.2 Hypoglycaemia, unspecified
0.000 0.300 0.700
E74 Other disorders of carbohydrate metabolism
0.002 0.304 0.694
G20-G26 Extrapyramidal and movement disorders
0.693 0.307 0.000
E13.9 Without complications
0.000 0.311 0.689
G40-G47 Episodic and paroxysmal disorders
0.683 0.317 0.000
G36 Other acute disseminated demyelination
0.681 0.319 0.000
I15 Secondary hypertension
0.000 0.324 0.676
E79 Disorders of purine and pyrimidine metabolism
0.002 0.325 0.673
E77 Disorders of glycoprotein metabolism
0.002 0.325 0.673
E76 Disorders of glycosaminoglycan metabolism
0.002 0.325 0.673
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.002 0.325 0.673
E72 Other disorders of amino-acid metabolism
0.002 0.325 0.673
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.002 0.325 0.673
E70 Disorders of aromatic amino-acid metabolism
0.002 0.325 0.673
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.002 0.325 0.673
I25.6 Silent myocardial ischaemia
0.000 0.329 0.671
I22.0 Subsequent myocardial infarction of anterior wall
0.000 0.329 0.671
I21.3 Acute transmural myocardial infarction of unspecified site
0.000 0.335 0.665
E83 Disorders of mineral metabolism
0.522 0.337 0.141
I24.1 Dressler's syndrome
0.000 0.342 0.658
E78.4 Other hyperlipidaemia
0.000 0.343 0.657
I21.X Presumed acute myicardial infaction (unconfirmed)
0.000 0.345 0.655
E40-E46 Malnutrition
0.000 0.346 0.654
Chapter IX Diseases of the circulatory system
0.000 0.347 0.653
E73 Lactose intolerance
0.002 0.350 0.648
E24 Cushing's syndrome
0.000 0.353 0.647
G31 Other degenerative diseases of nervous system, not elsewhere classified
0.645 0.355 0.000
E85.9 Amyloidosis, unspecified
0.001 0.357 0.643
G37.5 Concentric sclerosis [Balo]
0.642 0.358 0.000
G37.4 Subacute necrotising myelitis
0.642 0.358 0.000
G37.2 Central pontine myelinolysis
0.642 0.358 0.000
G37.1 Central demyelination of corpus callosum
0.642 0.358 0.000
G37.0 Diffuse sclerosis
0.642 0.358 0.000
G46 Vascular syndromes of brain in cerebrovascular diseases
0.623 0.377 0.000
G05 Encephalitis, myelitis and encephalomyelitis in diseases classified elsewhere
0.623 0.377 0.000
G40 Epilepsy
0.623 0.377 0.000
G31.9 Degenerative disease of nervous system, unspecified
0.617 0.383 0.000
G20 Parkinson's disease
0.616 0.384 0.000
I25.3 Aneurysm of heart
0.000 0.388 0.611
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.002 0.390 0.608
E84 Cystic fibrosis
0.002 0.390 0.608
G06 Intracranial and intraspinal abscess and granuloma
0.609 0.391 0.000
L40-L45 Papulosquamous disorders
0.000 0.393 0.607
E23 Hypofunction and other disorders of pituitary gland
0.000 0.393 0.607
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.394 0.606
I25.0 Atherosclerotic cardiovascular disease, so described
0.000 0.394 0.605
G03 Meningitis due to other and unspecified causes
0.605 0.395 0.000
E15 Nondiabetic hypoglycaemic coma
0.000 0.397 0.603
I11 Hypertensive heart disease
0.000 0.397 0.603
G37.3 Acute transverse myelitis in demyelinating disease of central nervous system
0.603 0.397 0.000
E22 Hyperfunction of pituitary gland
0.000 0.399 0.601
G09 Sequelae of inflammatory diseases of central nervous system
0.601 0.399 0.000
I20 Angina pectoris
0.000 0.399 0.601
I13 Hypertensive heart and renal disease
0.000 0.401 0.599
E11.8 With unspecified complications
0.000 0.401 0.599
G43 Migraine
0.589 0.411 0.000
E13.8 With unspecified complications
0.000 0.413 0.587
E13.7 With multiple complications
0.000 0.413 0.587
E13.6 With other specified complications
0.000 0.413 0.587
E13.5 With peripheral circulatory complications
0.000 0.413 0.587
E13.4 With neurological complications
0.000 0.413 0.587
E13.3 With ophthalmic complications
0.000 0.413 0.587
E13.2 With renal complications
0.000 0.413 0.587
E13.1 With ketoacidosis
0.000 0.413 0.587
E13.0 With coma
0.000 0.413 0.587
I25.4 Coronary artery aneurysm
0.000 0.416 0.584
E24.9 Cushing's syndrome, unspecified
0.000 0.417 0.583
G70-G73 Diseases of myoneural junction and muscle
0.578 0.422 0.000
E29 Testicular dysfunction
0.000 0.425 0.575
G30 Alzheimer's disease
0.565 0.435 0.000
G24 Dystonia
0.564 0.436 0.000
E89.3 Postprocedural hypopituitarism
0.001 0.436 0.563
I15.1 Hypertension secondary to other renal disorders
0.000 0.439 0.561
I23.8 Other current complications following acute myocardial infarction
0.000 0.443 0.556
E85.4 Organ-limited amyloidosis
0.001 0.448 0.551
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.448 0.551
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.448 0.551
E16.4 Abnormal secretion of gastrin
0.000 0.448 0.551
E16.3 Increased secretion of glucagon
0.000 0.448 0.551
E16.1 Other hypoglycaemia
0.000 0.448 0.551
E85.8 Other amyloidosis
0.001 0.449 0.550
E85.3 Secondary systemic amyloidosis
0.001 0.449 0.550
E85.2 Heredofamilial amyloidosis, unspecified
0.001 0.449 0.550
E85.1 Neuropathic heredofamilial amyloidosis
0.001 0.449 0.550
E85.0 Nonneuropathic heredofamilial amyloidosis
0.001 0.449 0.550
G80-G83 Cerebral palsy and other paralytic syndromes
0.544 0.456 0.000
E50-E64 Other nutritional deficiencies
0.000 0.457 0.543
G46.7 Other lacunar syndromes
0.542 0.458 0.000
G40.3 Generalised idiopathic epilepsy and epileptic syndromes
0.541 0.459 0.000
G05.1 Encephalitis, myelitis and encephalomyelitis in viral diseases classified elsewhere
0.541 0.459 0.000
G08 Intracranial and intraspinal phlebitis and thrombophlebitis
0.540 0.460 0.000
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.000 0.461 0.539
G40.6 Grand mal seizures, unspecified (with or without petit mal)
0.538 0.462 0.000
I20.0 Unstable angina
0.000 0.462 0.538
G04 Encephalitis, myelitis and encephalomyelitis
0.537 0.463 0.000
G31.2 Degeneration of nervous system due to alcohol
0.534 0.465 0.000
G46.4 Cerebellar stroke syndrome
0.530 0.470 0.000
G10-G14 Systemic atrophies primarily affecting the central nervous system
0.530 0.470 0.000
G02 Meningitis in other infectious and parasitic diseases classified elsewhere
0.529 0.471 0.000
G07 Intracranial and intraspinal abscess and granuloma in diseases classified elsewhere
0.529 0.471 0.000
G01 Meningitis in bacterial diseases classified elsewhere
0.529 0.471 0.000
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.472 0.528
E32 Diseases of thymus
0.000 0.472 0.528
E31 Polyglandular dysfunction
0.000 0.472 0.528
E30 Disorders of puberty, not elsewhere classified
0.000 0.472 0.528
E25 Adrenogenital disorders
0.000 0.472 0.528
G00 Bacterial meningitis, not elsewhere classified
0.526 0.474 0.000
E74.3 Other disorders of intestinal carbohydrate absorption
0.001 0.480 0.519
K90 Intestinal malabsorption
0.000 0.481 0.519
G40.1 Localisation-related (focal) (partial) symptomatic epilepsy and epileptic syndromes with simple partial seizures
0.518 0.482 0.000
L43 Lichen planus
0.000 0.483 0.517
I23.6 Thrombosis of atrium, auricular appendage and ventricle as current complications following acute myocardial infarction
0.000 0.484 0.516
I23.5 Rupture of papillary muscle as current complication following acute myocardial infarction
0.000 0.484 0.516
I23.4 Rupture of chordae tendineae as current complication following acute myocardial infarction
0.000 0.484 0.516
I23.3 Rupture of cardiac wall without haemopericardium as current complication following acute myocardial infarction
0.000 0.484 0.516
I23.2 Ventricular septal defect as current complication following acute myocardial infarction
0.000 0.484 0.516
I23.1 Atrial septal defect as current complication following acute myocardial infarction
0.000 0.484 0.516
I23.0 Haemopericardium as current complication following acute myocardial infarction
0.000 0.484 0.516
E28 Ovarian dysfunction
0.000 0.485 0.515
E12.9 Without complications
0.000 0.486 0.514
E12.8 With unspecified complications
0.000 0.486 0.514
E12.7 With multiple complications
0.000 0.486 0.514
E12.6 With other specified complications
0.000 0.486 0.514
E12.5 With peripheral circulatory complications
0.000 0.486 0.514
E12.4 With neurological complications
0.000 0.486 0.514
E12.3 With ophthalmic complications
0.000 0.486 0.514
E12.2 With renal complications
0.000 0.486 0.514
E12.1 With ketoacidosis
0.000 0.486 0.514
E12.0 With coma
0.000 0.486 0.514
G03.9 Meningitis, unspecified
0.510 0.490 0.000
G32 Other degenerative disorders of nervous system in diseases classified elsewhere
0.509 0.491 0.000
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.000 0.493 0.507
E23.0 Hypopituitarism
0.000 0.500 0.500
E74.9 Disorder of carbohydrate metabolism, unspecified
0.001 0.501 0.498
E74.8 Other specified disorders of carbohydrate metabolism
0.001 0.501 0.498
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
0.001 0.501 0.498
E74.2 Disorders of galactose metabolism
0.001 0.501 0.498
E74.1 Disorders of fructose metabolism
0.001 0.501 0.498
E74.0 Glycogen storage disease
0.001 0.501 0.498
I22.8 Subsequent myocardial infarction of other sites
0.000 0.501 0.498
G23 Other degenerative diseases of basal ganglia
0.497 0.503 0.000
G21 Secondary Parkinsonism
0.497 0.503 0.000
G26 Extrapyramidal and movement disorders in diseases classified elsewhere
0.497 0.503 0.000
G22 Parkinsonism in diseases classified elsewhere
0.497 0.503 0.000
G43.9 Migraine, unspecified
0.492 0.508 0.000
G06.1 Intraspinal abscess and granuloma
0.491 0.509 0.000
G36.9 Acute disseminated demyelination, unspecified
0.488 0.511 0.000
G36.8 Other specified acute disseminated demyelination
0.488 0.511 0.000
G36.1 Acute and subacute haemorrhagic leukoencephalitis [Hurst]
0.488 0.511 0.000
G36.0 Neuromyelitis optica [Devic]
0.488 0.511 0.000
I21.0 Acute transmural myocardial infarction of anterior wall
0.000 0.513 0.487
G43.8 Other migraine
0.486 0.514 0.000
G40.7 Petit mal, unspecified, without grand mal seizures
0.486 0.514 0.000
I15.9 Seconday hypertension, unspecified
0.000 0.515 0.484
I15.8 Other secondary hypertension
0.000 0.515 0.484
I15.2 Hypertension secondary to endocrine disorders
0.000 0.515 0.484
I15.0 Renovascular hypertension
0.000 0.515 0.484
G44 Other headache syndromes
0.484 0.515 0.000
E70.9 Disorder of aromatic amino-acid metabolism, unspecified
0.001 0.516 0.483
E70.8 Other disorders of aromatic amino-acid metabolism
0.001 0.516 0.483
E70.3 Albinism
0.001 0.516 0.483
E70.2 Disorders of tyrosine metabolism
0.001 0.516 0.483
E70.1 Other hyperphenylalaninaemias
0.001 0.516 0.483
E70.0 Classical phenylketonuria
0.001 0.516 0.483
E71.3 Disorders of fatty-acid metabolism
0.001 0.516 0.483
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified
0.001 0.516 0.483
E71.1 Other disorders of branched-chain amino-acid metabolism
0.001 0.516 0.483
E71.0 Maple-syrup-urine disease
0.001 0.516 0.483
E72.9 Disorder of amino-acid metabolism, unspecified
0.001 0.516 0.483
E72.8 Other specified disorders of amino-acid metabolism
0.001 0.516 0.483
E72.5 Disorders of glycine metabolism
0.001 0.516 0.483
E72.4 Disorders of ornithine metabolism
0.001 0.516 0.483
E72.3 Disorders of lysine and hydroxylysine metabolism
0.001 0.516 0.483
E72.2 Disorders of urea cycle metabolism
0.001 0.516 0.483
E72.1 Disorders of sulphur-bearing amino-acid metabolism
0.001 0.516 0.483
E72.0 Disorders of amino-acid transport
0.001 0.516 0.483
E75.6 Lipid storage disorder, unspecified
0.001 0.516 0.483
E75.5 Other lipid storage disorders
0.001 0.516 0.483
E75.4 Neuronal ceroid lipofuscinosis
0.001 0.516 0.483
E75.3 Sphingolipidosis, unspecified
0.001 0.516 0.483
E75.2 Other sphingolipidosis
0.001 0.516 0.483
E75.1 Other gangliosidosis
0.001 0.516 0.483
E75.0 GM2 gangliosidosis
0.001 0.516 0.483
E76.9 Disorder of glucosaminoglycan metabolism, unspecified
0.001 0.516 0.483
E76.8 Other disorders of glucosaminoglycan metabolism
0.001 0.516 0.483
E76.3 Mucopolysaccharidosis, unspecified
0.001 0.516 0.483
E76.2 Other mucopolysaccharidoses
0.001 0.516 0.483
E76.1 Mucopolysaccharidosis, type II
0.001 0.516 0.483
E76.0 Mucopolysaccharidosis, type I
0.001 0.516 0.483
E77.9 Disorder of glycoprotein metabolism, unspecified
0.001 0.516 0.483
E77.8 Other disorders of glycoprotein metabolism
0.001 0.516 0.483
E77.1 Defects in glycoprotein degradation
0.001 0.516 0.483
E77.0 Defects in posttranslational modification of lysosomal enzymes
0.001 0.516 0.483
E79.9 Disorder of purine and pyrimidine metabolism, unspecified
0.001 0.516 0.483
E79.8 Other disorders of purine and pyrimidine metabolism
0.001 0.516 0.483
E79.1 Lesch-Nyhan syndrome
0.001 0.516 0.483
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
0.001 0.516 0.483
G41 Status epilepticus
0.483 0.517 0.000
G24.9 Dystonia, unspecified
0.482 0.518 0.000
E80 Disorders of porphyrin and bilirubin metabolism
0.002 0.519 0.479
E88 Other metabolic disorders
0.002 0.520 0.478
G30.8 Other Alzheimer's disease
0.476 0.523 0.000
E83.9 Disorder of mineral metabolism, unspecified
0.374 0.524 0.102
E83.8 Other disorders of mineral metabolism
0.374 0.524 0.102
E83.2 Disorders of zinc metabolism
0.374 0.524 0.102
E83.0 Disorders of copper metabolism
0.374 0.524 0.102
E20 Hypoparathyroidism
0.000 0.526 0.474
E26 Hyperaldosteronism
0.000 0.526 0.473
G70 Myasthenia gravis and other myoneural disorders
0.470 0.530 0.000
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.531 0.469
E45 Retarded development following protein-energy malnutrition
0.000 0.531 0.469
E43 Unspecified severe protein-energy malnutrition
0.000 0.531 0.469
E42 Marasmic kwashiorkor
0.000 0.531 0.469
E41 Nutritional marasmus
0.000 0.531 0.469
E40 Kwashiorkor
0.000 0.531 0.469
I00-I02 Acute rheumatic fever
0.000 0.531 0.469
L43.9 Lichen planus, unspecified
0.000 0.534 0.466
E73.8 Other lactose intolerance
0.001 0.534 0.465
E73.1 Secondary lactase deficiency
0.001 0.534 0.465
E73.0 Congenital lactase deficiency
0.001 0.534 0.465
E24.8 Other Cushing's syndrome
0.000 0.536 0.464
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.000 0.536 0.464
E24.3 Ectopic ACTH syndrome
0.000 0.536 0.464
E24.2 Drug-induced Cushing's syndrome
0.000 0.536 0.464
E24.1 Nelson's syndrome
0.000 0.536 0.464
E24.0 Pituitary-dependent Cushing's disease
0.000 0.536 0.464
G31.1 Senile degeneration of brain, not elsewhere classified
0.462 0.538 0.000
G25 Other extrapyramidal and movement disorders
0.460 0.540 0.000
E29.1 Testicular hypofunction
0.000 0.541 0.459
G06.2 Extradural and subdural abscess, unspecified
0.459 0.541 0.000
G06.0 Intracranial abscess and granuloma
0.454 0.546 0.000
E22.1 Hyperprolactinaemia
0.000 0.547 0.453
G72 Other myopathies
0.447 0.553 0.000
G46.8 Other vascular syndromes of brain in cerebrovascular diseases
0.447 0.553 0.000
G46.6 Pure sensory lacunar syndrome
0.447 0.553 0.000
G46.5 Pure motor lacunar syndrome
0.447 0.553 0.000
G46.3 Brain stem stroke syndrome
0.447 0.553 0.000
G46.2 Posterior cerebral artery syndrome
0.447 0.553 0.000
G46.1 Anterior cerebral artery syndrome
0.447 0.553 0.000
G46.0 Middle cerebral artery syndrome
0.447 0.553 0.000
G05.8 Encephalitis, myelitis and encephalomyelitis in other diseases classified elsewhere
0.447 0.553 0.000
G05.2 Encephalitis, myelitis and encephalomyelitis in other infectious and parasitic diseases classified elsewhere
0.447 0.553 0.000
G05.0 Encephalitis, myelitis and encephalomyelitis in bacterial diseases classified elsewhere
0.447 0.553 0.000
G40.4 Other generalised epilepsy and epileptic syndromes
0.447 0.553 0.000
G40.0 Localisation-related (focal) (partial) idiopathic epilepsy and epileptic syndromes with seizures of localised onset
0.447 0.553 0.000
E46 Unspecified protein-energy malnutrition
0.000 0.553 0.447
G24.8 Other dystonia
0.447 0.553 0.000
E23.6 Other disorders of pituitary gland
0.000 0.554 0.446
G83 Other paralytic syndromes
0.445 0.555 0.000
E23.7 Disorder of pituitary gland, unspecified
0.000 0.557 0.443
E61 Deficiency of other nutrient elements
0.000 0.557 0.443
E73.9 Lactose intolerance, unspecified
0.001 0.559 0.439
E83.5 Disorders of calcium metabolism
0.424 0.561 0.015
E23.2 Diabetes insipidus
0.000 0.561 0.439
E89.9 Postprocedural endocrine and metabolic disorder, unspecified
0.002 0.562 0.436
E89.8 Other postprocedural endocrine and metabolic disorders
0.002 0.562 0.436
E89.6 Postprocedural adrenocortical(-medullary) hypofunction
0.002 0.562 0.436
E89.5 Postprocedural testicular hypofunction
0.002 0.562 0.436
E89.1 Postprocedural hypoinsulinaemia
0.002 0.562 0.436
E84.8 Cystic fibrosis with other manifestations
0.002 0.562 0.436
E84.1 Cystic fibrosis with intestinal manifestations
0.002 0.562 0.436
E84.0 Cystic fibrosis with pulmonary manifestations
0.002 0.562 0.436
E83.3 Disorders of phosphorus metabolism
0.354 0.562 0.083
E21.3 Hyperparathyroidism, unspecified
0.000 0.564 0.436
I11.0 Hypertensive heart disease with (congestive) heart failure
0.000 0.564 0.436
L44 Other papulosquamous disorders
0.000 0.565 0.435
L41 Parapsoriasis
0.000 0.565 0.435
L45 Papulosquamous disorders in diseases classified elsewhere
0.000 0.565 0.435
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.000 0.565 0.435
E23.1 Drug-induced hypopituitarism
0.000 0.565 0.435
G03.8 Meningitis due to other specified causes
0.434 0.566 0.000
G03.2 Benign recurrent meningitis [Mollaret]
0.434 0.566 0.000
G03.1 Chronic meningitis
0.434 0.566 0.000
G03.0 Nonpyogenic meningitis
0.434 0.566 0.000
I11.9 Hypertensive heart disease without (congestive) heart failure
0.000 0.566 0.434
G30.0 Alzheimer's disease with early onset
0.432 0.568 0.000
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.569 0.431
E22.8 Other hyperfunction of pituitary gland
0.000 0.569 0.431
I13.9 Hypertensive heart and renal disease, unspecified
0.000 0.570 0.430
I13.2 Hypertensive heart and renal disease with both (congestive) heart failure and renal failure
0.000 0.570 0.430
I13.1 Hypertensive heart and renal disease with renal failure
0.000 0.570 0.430
I13.0 Hypertensive heart and renal disease with (congestive) heart failure
0.000 0.570 0.430
G40.9 Epilepsy, unspecified
0.428 0.572 0.000
G31.0 Circumscribed brain atrophy
0.427 0.573 0.000
G82 Paraplegia and tetraplegia
0.426 0.573 0.000
G43.0 Migraine without aura [common migraine]
0.424 0.576 0.000
G43.3 Complicated migraine
0.422 0.578 0.000
G43.2 Status migrainosus
0.422 0.578 0.000
E78.9 Disorder of lipoprotein metabolism, unspecified
0.000 0.583 0.416
E34 Other endocrine disorders
0.000 0.585 0.415
G73 Disorders of myoneural junction and muscle in diseases classified elsewhere
0.414 0.586 0.000
G10 Huntington's disease
0.413 0.587 0.000
E29.9 Testicular dysfunction, unspecified
0.000 0.588 0.412
E29.8 Other testicular dysfunction
0.000 0.588 0.412
E29.0 Testicular hyperfunction
0.000 0.588 0.412
G40.5 Special epileptic syndromes
0.409 0.590 0.000
E28.2 Polycystic ovarian syndrome
0.000 0.594 0.406
E89.2 Postprocedural hypoparathyroidism
0.002 0.594 0.404
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.000 0.595 0.405
G30.1 Alzheimer's disease with late onset
0.405 0.595 0.000
G24.4 Idiopathic orofacial dystonia
0.404 0.595 0.000
G24.3 Spasmodic torticollis
0.404 0.595 0.000
G24.2 Idiopathic nonfamilial dystonia
0.404 0.595 0.000
G24.1 Idiopathic familial dystonia
0.404 0.595 0.000
G24.0 Drug-induced dystonia
0.404 0.595 0.000
M06.9 Rheumatoid arthritis, unspecified
0.000 0.597 0.403
E22.0 Acromegaly and pituitary gigantism
0.000 0.600 0.400
G44.0 Cluster headache syndrome
0.399 0.601 0.000
G43.1 Migraine with aura [classical migraine]
0.398 0.602 0.000
I20.1 Angina pectoris with documented spasm
0.000 0.602 0.398
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.000 0.603 0.397
G70.9 Myoneural disorder, unspecified
0.396 0.604 0.000
L42 Pityriasis rosea
0.000 0.606 0.394
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)
0.000 0.607 0.393
G40.2 Localisation-related (focal) (partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
0.393 0.607 0.000
K90.9 Intestinal malabsorption, unspecified
0.000 0.607 0.393
G04.9 Encephalitis, myelitis and encephalomyelitis, unspecified
0.392 0.608 0.000
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.611 0.389
E63 Other nutritional deficiencies
0.000 0.611 0.389
E56 Other vitamin deficiencies
0.000 0.611 0.389
E51 Thiamine deficiency
0.000 0.611 0.389
E50 Vitamin A deficiency
0.000 0.611 0.389
E60 Dietary zinc deficiency
0.000 0.611 0.389
E59 Dietary selenium deficiency
0.000 0.611 0.389
E58 Dietary calcium deficiency
0.000 0.611 0.389
E54 Ascorbic acid deficiency
0.000 0.611 0.389
E52 Niacin deficiency [pellagra]
0.000 0.611 0.389
G04.8 Other encephalitis, myelitis and encephalomyelitis
0.387 0.613 0.000
E21.5 Disorder of parathyroid gland, unspecified
0.000 0.613 0.387
E21.4 Other specified disorders of parathyroid gland
0.000 0.613 0.387
E21.2 Other hyperparathyroidism
0.000 0.613 0.387
G04.2 Bacterial meningoencephalitis and meningomyelitis, not elsewhere classified
0.385 0.615 0.000
G04.1 Tropical spastic paraplegia
0.385 0.615 0.000
G04.0 Acute disseminated encephalitis
0.385 0.615 0.000
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)
0.000 0.616 0.384
I20.8 Other forms of angina pectoris
0.000 0.617 0.383
G40.8 Other epilepsy
0.383 0.617 0.000
G82.1 Spastic paraplegia
0.382 0.618 0.000
E11.3 With ophthalmic complications
0.000 0.618 0.382
G13 Systemic atrophies primarily affecting central nervous system in diseases classified elsewhere
0.380 0.620 0.000
G14 Postpolio syndrome
0.380 0.620 0.000
G02.8 Meningitis in other specified infectious and parasitic diseases classified elsewhere
0.379 0.620 0.000
G02.1 Meningitis in mycoses
0.379 0.620 0.000
G02.0 Meningitis in viral diseases classified elsewhere
0.379 0.620 0.000
G00.9 Bacterial meningitis, unspecified
0.379 0.620 0.000
E89.4 Postprocedural ovarian failure
0.002 0.621 0.377
E25.9 Adrenogenital disorder, unspecified
0.000 0.621 0.378
E25.8 Other adrenogenital disorders
0.000 0.621 0.378
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.000 0.621 0.378
E30.9 Disorder of puberty, unspecified
0.000 0.621 0.378
E30.8 Other disorders of puberty
0.000 0.621 0.378
E30.1 Precocious puberty
0.000 0.621 0.378
E30.0 Delayed puberty
0.000 0.621 0.378
E31.9 Polyglandular dysfunction, unspecified
0.000 0.621 0.378
E31.8 Other polyglandular dysfunction
0.000 0.621 0.378
E31.1 Polyglandular hyperfunction
0.000 0.621 0.378
E31.0 Autoimmune polyglandular failure
0.000 0.621 0.378
E32.9 Disease of thymus, unspecified
0.000 0.621 0.378
E32.8 Other diseases of thymus
0.000 0.621 0.378
E32.1 Abscess of thymus
0.000 0.621 0.378
E32.0 Persistent hyperplasia of thymus
0.000 0.621 0.378
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.621 0.378
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.621 0.378
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.621 0.378
G00.8 Other bacterial meningitis
0.377 0.623 0.000
G00.3 Staphylococcal meningitis
0.377 0.623 0.000
G00.2 Streptococcal meningitis
0.377 0.623 0.000
G00.0 Haemophilus meningitis
0.377 0.623 0.000
E84.9 Cystic fibrosis, unspecified
0.002 0.627 0.371
K90.8 Other intestinal malabsorption
0.000 0.628 0.372
K90.3 Pancreatic steatorrhoea
0.000 0.628 0.372
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.628 0.372
K90.1 Tropical sprue
0.000 0.628 0.372
G00.1 Pneumococcal meningitis
0.372 0.628 0.000
E61.1 Iron deficiency
0.000 0.629 0.371
L43.3 Subacute (active) lichen planus
0.000 0.629 0.371
L43.2 Lichenoid drug reaction
0.000 0.629 0.371
L43.1 Bullous lichen planus
0.000 0.629 0.371
L43.0 Hypertrophic lichen planus
0.000 0.629 0.371
E28.9 Ovarian dysfunction, unspecified
0.000 0.631 0.369
E28.8 Other ovarian dysfunction
0.000 0.631 0.369
E28.1 Androgen excess
0.000 0.631 0.369
E28.0 Oestrogen excess
0.000 0.631 0.369
G80 Infantile cerebral palsy
0.368 0.632 0.000
G25.9 Extrapyramidal and movement disorder, unspecified
0.368 0.632 0.000
G83.4 Cauda equina syndrome
0.367 0.633 0.000
G32.8 Other specified degenerative disorders of nervous system in diseases classified elsewhere
0.365 0.635 0.000
G32.0 Subacute combined degeneration of spinal cord in diseases classified elsewhere
0.365 0.635 0.000
M06.94 Rheumatoid arthritis, unspecified (Hand)
0.000 0.636 0.364
G11 Hereditary ataxia
0.364 0.636 0.000
I21.1 Acute transmural myocardial infarction of inferior wall
0.000 0.636 0.364
G44.2 Tension-type headache
0.361 0.639 0.000
G21.9 Secondary Parkinsonism, unspecified
0.356 0.644 0.000
G21.8 Other secondary Parkinsonism
0.356 0.644 0.000
G21.4 Vascular parkinsonism
0.356 0.644 0.000
G21.3 Postencephalitic Parkinsonism
0.356 0.644 0.000
G21.2 Secondary Parkinsonism due to other external agents
0.356 0.644 0.000
G21.1 Other drug-induced secondary Parkinsonism
0.356 0.644 0.000
G21.0 Malignant neuroleptic syndrome
0.356 0.644 0.000
G23.9 Degenerative disease of basal ganglia, unspecified
0.356 0.644 0.000
G23.8 Other specified degenerative diseases of basal ganglia
0.356 0.644 0.000
G23.3 Multiple system atrophy, cerebellar type
0.356 0.644 0.000
G23.2 Striatonigral degeneration
0.356 0.644 0.000
G23.1 Progressive supranuclear ophthalmoplegia [Steele-Richardson-Olszewski]
0.356 0.644 0.000
G23.0 Hallervorden-Spatz disease
0.356 0.644 0.000
G72.9 Myopathy, unspecified
0.354 0.646 0.000
I05-I09 Chronic rheumatic heart diseases
0.000 0.648 0.352
G83.8 Other specified paralytic syndromes
0.350 0.650 0.000
G41.0 Grand mal status epilepticus
0.348 0.651 0.000
G44.3 Chronic posttraumatic headache
0.347 0.652 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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