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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs2517489
log Bayes Factor = 70.5069
Chromosome 6   position 31,042,306  (GRCh37) Explore rs2517489 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E03.9 Hypothyroidism, unspecified
1.000 0.000 0.000
K90.0 Coeliac disease
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
R31 Unspecified haematuria
1.000 0.000 0.000
L40.9 Psoriasis, unspecified
0.000 0.000 1.000
E10-E14 Diabetes mellitus
0.000 0.002 0.998
E10.1 With ketoacidosis
0.000 0.003 0.997
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.005 0.995
L40 Psoriasis
0.000 0.005 0.995
E10.9 Without complications
0.000 0.005 0.995
E16.2 Hypoglycaemia, unspecified
0.000 0.005 0.995
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.006 0.994
E16 Other disorders of pancreatic internal secretion
0.000 0.006 0.994
E10.3 With ophthalmic complications
0.000 0.007 0.993
L40.5 Arthropathic psoriasis
0.000 0.014 0.986
E00-E07 Disorders of thyroid gland
0.075 0.030 0.895
D86.9 Sarcoidosis, unspecified
0.000 0.040 0.960
D86 Sarcoidosis
0.000 0.041 0.959
L40.0 Psoriasis vulgaris
0.000 0.050 0.950
D80-D89 Certain disorders involving the immune mechanism
0.000 0.062 0.938
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.000 0.073 0.927
D70-D77 Other diseases of blood and blood-forming organs
0.000 0.080 0.920
D70 Agranulocytosis
0.000 0.085 0.915
E10.2 With renal complications
0.000 0.093 0.907
E05 Thyrotoxicosis [hyperthyroidism]
0.013 0.094 0.893
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.101 0.898
E10.8 With unspecified complications
0.000 0.111 0.889
D50-D53 Nutritional anaemias
0.000 0.113 0.887
D86.1 Sarcoidosis of lymph nodes
0.000 0.120 0.880
E11 Non-insulin-dependent diabetes mellitus
0.000 0.120 0.880
D51 Vitamin B12 deficiency anaemia
0.000 0.131 0.869
E10.4 With neurological complications
0.000 0.139 0.861
E10.5 With peripheral circulatory complications
0.000 0.150 0.850
D51.0 Vitamin B12 deficiency anaemia due to intrinsic factor deficiency
0.000 0.165 0.835
E10.6 With other specified complications
0.000 0.190 0.810
E11.5 With peripheral circulatory complications
0.000 0.192 0.808
D86.0 Sarcoidosis of lung
0.000 0.196 0.804
D72 Other disorders of white blood cells
0.000 0.198 0.802
L40.1 Generalised pustular psoriasis
0.000 0.200 0.799
E50-E64 Other nutritional deficiencies
0.000 0.221 0.779
D51.9 Vitamin B12 deficiency anaemia, unspecified
0.000 0.223 0.777
E11.4 With neurological complications
0.000 0.229 0.771
E03 Other hypothyroidism
0.459 0.230 0.312
E11.3 With ophthalmic complications
0.000 0.232 0.768
L40.4 Guttate psoriasis
0.000 0.234 0.766
E10.0 With coma
0.000 0.242 0.758
D86.8 Sarcoidosis of other and combined sites
0.000 0.244 0.756
D53 Other nutritional anaemias
0.000 0.245 0.754
D80 Immunodeficiency with predominantly antibody defects
0.000 0.249 0.751
D75 Other diseases of blood and blood-forming organs
0.000 0.256 0.744
D55-D59 Haemolytic anaemias
0.000 0.259 0.741
E14 Unspecified diabetes mellitus
0.000 0.260 0.740
D83 Common variable immunodeficiency
0.000 0.262 0.738
D86.3 Sarcoidosis of skin
0.000 0.262 0.738
D86.2 Sarcoidosis of lung with sarcoidosis of lymph nodes
0.000 0.268 0.732
E11.8 With unspecified complications
0.000 0.273 0.727
E55 Vitamin D deficiency
0.000 0.279 0.721
D72.8 Other specified disorders of white blood cells
0.000 0.279 0.721
E10.7 With multiple complications
0.000 0.283 0.717
E12 Malnutrition-related diabetes mellitus
0.000 0.284 0.716
L40.3 Pustulosis palmaris et plantaris
0.000 0.287 0.713
L40.2 Acrodermatitis continua
0.000 0.287 0.713
E15 Nondiabetic hypoglycaemic coma
0.000 0.287 0.713
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.287 0.713
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.287 0.713
E16.4 Abnormal secretion of gastrin
0.000 0.287 0.713
E16.3 Increased secretion of glucagon
0.000 0.287 0.713
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.054 0.305 0.642
E00 Congenital iodine-deficiency syndrome
0.054 0.305 0.642
D59 Acquired haemolytic anaemia
0.000 0.307 0.693
E13 Other specified diabetes mellitus
0.000 0.310 0.690
E40-E46 Malnutrition
0.000 0.312 0.688
E11.1 With ketoacidosis
0.000 0.317 0.683
E55.9 Vitamin D deficiency, unspecified
0.000 0.320 0.680
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.326 0.674
E16.1 Other hypoglycaemia
0.000 0.326 0.674
E06 Thyroiditis
0.039 0.327 0.634
D81 Combined immunodeficiencies
0.000 0.327 0.673
E02 Subclinical iodine-deficiency hypothyroidism
0.052 0.331 0.616
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions
0.000 0.337 0.663
D74 Methaemoglobinaemia
0.000 0.340 0.660
D77 Other disorders of blood and blood-forming organs in diseases classified elsewhere
0.000 0.340 0.660
D71 Functional disorders of polymorphonuclear neutrophils
0.000 0.340 0.660
D53.9 Nutritional anaemia, unspecified
0.000 0.340 0.660
E05.5 Thyroid crisis or storm
0.009 0.350 0.640
E05.4 Thyrotoxicosis factitia
0.009 0.350 0.640
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.009 0.350 0.640
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.009 0.350 0.640
D82 Immunodeficiency associated with other major defects
0.000 0.358 0.642
D75.9 Disease of blood and blood-forming organs, unspecified
0.000 0.359 0.641
E11.7 With multiple complications
0.000 0.369 0.631
D59.9 Acquired haemolytic anaemia, unspecified
0.000 0.376 0.624
D51.8 Other vitamin B12 deficiency anaemias
0.000 0.377 0.623
D51.3 Other dietary vitamin B12 deficiency anaemia
0.000 0.377 0.623
D51.2 Transcobalamin II deficiency
0.000 0.377 0.623
D51.1 Vitamin B12 deficiency anaemia due to selective vitamin B12 malabsorption with proteinuria
0.000 0.377 0.623
E11.6 With other specified complications
0.000 0.377 0.623
E14.3 With ophthalmic complications
0.000 0.378 0.621
D80.1 Nonfamilial hypogammaglobulinaemia
0.000 0.380 0.620
D76 Certain diseases involving lymphoreticular tissue and reticulohistiocytic system
0.000 0.391 0.609
E05.8 Other thyrotoxicosis
0.009 0.393 0.598
E14.8 With unspecified complications
0.000 0.397 0.603
D83.9 Common variable immunodeficiency, unspecified
0.000 0.405 0.595
D59.1 Other autoimmune haemolytic anaemias
0.000 0.407 0.593
E83.1 Disorders of iron metabolism
0.000 0.410 0.590
D80.2 Selective deficiency of immunoglobulin A [IgA]
0.000 0.414 0.586
D75.0 Familial erythrocytosis
0.000 0.419 0.581
D80.3 Selective deficiency of immunoglobulin G [IgG] subclasses
0.000 0.420 0.580
D72.9 Disorder of white blood cells, unspecified
0.000 0.425 0.575
D72.0 Genetic anomalies of leukocytes
0.000 0.425 0.575
E51 Thiamine deficiency
0.000 0.426 0.573
E06.9 Thyroiditis, unspecified
0.015 0.429 0.556
E14.1 With ketoacidosis
0.000 0.430 0.570
D72.1 Eosinophilia
0.000 0.433 0.567
D84 Other immunodeficiencies
0.000 0.435 0.564
E14.6 With other specified complications
0.000 0.437 0.563
L40.8 Other psoriasis
0.000 0.439 0.561
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.442 0.558
E63 Other nutritional deficiencies
0.000 0.442 0.558
E50 Vitamin A deficiency
0.000 0.442 0.558
E60 Dietary zinc deficiency
0.000 0.442 0.558
E59 Dietary selenium deficiency
0.000 0.442 0.558
E52 Niacin deficiency [pellagra]
0.000 0.442 0.558
E03.5 Myxoedema coma
0.329 0.447 0.223
E03.4 Atrophy of thyroid (acquired)
0.329 0.447 0.223
E03.3 Postinfectious hypothyroidism
0.329 0.447 0.223
E07 Other disorders of thyroid
0.090 0.448 0.462
E20-E35 Disorders of other endocrine glands
0.000 0.450 0.550
E65-E68 Obesity and other hyperalimentation
0.000 0.451 0.549
E70-E90 Metabolic disorders
0.000 0.453 0.547
E03.0 Congenital hypothyroidism with diffuse goitre
0.327 0.456 0.217
E53 Deficiency of other B group vitamins
0.000 0.457 0.543
E27.1 Primary adrenocortical insufficiency
0.000 0.458 0.542
D53.8 Other specified nutritional anaemias
0.000 0.459 0.541
D53.2 Scorbutic anaemia
0.000 0.459 0.541
D53.1 Other megaloblastic anaemias, not elsewhere classified
0.000 0.459 0.541
D53.0 Protein deficiency anaemia
0.000 0.459 0.541
E83 Disorders of mineral metabolism
0.000 0.460 0.540
E27 Other disorders of adrenal gland
0.000 0.460 0.540
D80.8 Other immunodeficiencies with predominantly antibody defects
0.000 0.461 0.538
D80.7 Transient hypogammaglobulinaemia of infancy
0.000 0.461 0.538
D80.6 Antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinaemia
0.000 0.461 0.538
D80.5 Immunodeficiency with increased immunoglobulin M [IgM]
0.000 0.461 0.538
D80.0 Hereditary hypogammaglobulinaemia
0.000 0.461 0.538
D66 Hereditary factor VIII deficiency
0.000 0.461 0.539
E54 Ascorbic acid deficiency
0.000 0.465 0.535
D55 Anaemia due to enzyme disorders
0.000 0.468 0.532
E14.7 With multiple complications
0.000 0.469 0.531
E14.2 Withrenal complications
0.000 0.469 0.531
E14.0 With coma
0.000 0.469 0.531
E03.1 Congenital hypothyroidism without goitre
0.292 0.470 0.239
D83.8 Other common variable immunodeficiencies
0.000 0.470 0.529
D83.2 Common variable immunodeficiency with autoantibodies to B- or T-cells
0.000 0.470 0.529
D83.1 Common variable immunodeficiency with predominant immunoregulatory T-cell disorders
0.000 0.470 0.529
D83.0 Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function
0.000 0.470 0.529
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.344 0.471 0.185
D75.2 Essential thrombocytosis
0.000 0.472 0.528
D65 Disseminated intravascular coagulation [defibrination syndrome]
0.000 0.473 0.527
E55.0 Rickets, active
0.000 0.483 0.517
D89 Other disorders involving the immune mechanism, not elsewhere classified
0.000 0.484 0.516
E12.9 Without complications
0.000 0.487 0.513
E12.8 With unspecified complications
0.000 0.487 0.513
E12.7 With multiple complications
0.000 0.487 0.513
E12.6 With other specified complications
0.000 0.487 0.513
E12.5 With peripheral circulatory complications
0.000 0.487 0.513
E12.4 With neurological complications
0.000 0.487 0.513
E12.3 With ophthalmic complications
0.000 0.487 0.513
E12.2 With renal complications
0.000 0.487 0.513
E12.1 With ketoacidosis
0.000 0.487 0.513
E12.0 With coma
0.000 0.487 0.513
E58 Dietary calcium deficiency
0.000 0.488 0.512
E14.5 With peripheral circulatory complications
0.000 0.490 0.510
E13.9 Without complications
0.000 0.493 0.507
E56 Other vitamin deficiencies
0.000 0.493 0.507
D57 Sickle-cell disorders
0.000 0.494 0.506
D69 Purpura and other haemorrhagic conditions
0.000 0.497 0.503
D80.9 Immunodeficiency with predominantly antibody defects, unspecified
0.000 0.499 0.501
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.039 0.501 0.460
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.039 0.501 0.460
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.039 0.501 0.460
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.039 0.501 0.460
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.039 0.501 0.460
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.039 0.501 0.460
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.039 0.501 0.460
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.039 0.501 0.460
D59.8 Other acquired haemolytic anaemias
0.000 0.503 0.497
D59.6 Haemoglobinuria due to haemolysis from other external causes
0.000 0.503 0.497
D59.5 Paroxysmal nocturnal haemoglobinuria [Marchiafava-Micheli]
0.000 0.503 0.497
D59.4 Other nonautoimmune haemolytic anaemias
0.000 0.503 0.497
D59.3 Haemolytic-uraemic syndrome
0.000 0.503 0.497
D59.2 Drug-induced nonautoimmune haemolytic anaemia
0.000 0.503 0.497
D59.0 Drug-induced autoimmune haemolytic anaemia
0.000 0.503 0.497
E88 Other metabolic disorders
0.000 0.504 0.496
E13.8 With unspecified complications
0.000 0.505 0.495
E13.7 With multiple complications
0.000 0.505 0.495
E13.6 With other specified complications
0.000 0.505 0.495
E13.5 With peripheral circulatory complications
0.000 0.505 0.495
E13.4 With neurological complications
0.000 0.505 0.495
E13.2 With renal complications
0.000 0.505 0.495
E13.1 With ketoacidosis
0.000 0.505 0.495
E13.0 With coma
0.000 0.505 0.495
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.506 0.494
E45 Retarded development following protein-energy malnutrition
0.000 0.506 0.494
E43 Unspecified severe protein-energy malnutrition
0.000 0.506 0.494
E42 Marasmic kwashiorkor
0.000 0.506 0.494
E41 Nutritional marasmus
0.000 0.506 0.494
E40 Kwashiorkor
0.000 0.506 0.494
E03.8 Other specified hypothyroidism
0.300 0.506 0.194
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.009 0.507 0.484
D75.1 Secondary polycythaemia
0.000 0.513 0.487
E14.4 With neurological complications
0.000 0.515 0.485
D67 Hereditary factor IX deficiency
0.000 0.517 0.483
E06.4 Drug-induced thyroiditis
0.028 0.517 0.455
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.028 0.517 0.455
E06.0 Acute thyroiditis
0.028 0.517 0.455
D81.9 Combined immunodeficiency, unspecified
0.000 0.517 0.482
D81.8 Other combined immunodeficiencies
0.000 0.517 0.482
D81.7 Major histocompatibility complex class II deficiency
0.000 0.517 0.482
D81.6 Major histocompatibility complex class I deficiency
0.000 0.517 0.482
D81.5 Purine nucleoside phosphorylase [PNP] deficiency
0.000 0.517 0.482
D81.4 Nezelof's syndrome
0.000 0.517 0.482
D81.3 Adenosine deaminase [ADA] deficiency
0.000 0.517 0.482
D81.2 Severe combined immunodeficiency [SCID] with low or normal B-cell numbers
0.000 0.517 0.482
D81.1 Severe combined immunodeficiency [SCID] with low T- and B-cell numbers
0.000 0.517 0.482
D81.0 Severe combined immunodeficiency [SCID] with reticular dysgenesis
0.000 0.517 0.482
D75.8 Other specified diseases of blood and blood-forming organs
0.000 0.520 0.480
D74.9 Methaemoglobinaemia, unspecified
0.000 0.527 0.473
D74.8 Other methaemoglobinaemias
0.000 0.527 0.473
D74.0 Congenital methaemoglobinaemia
0.000 0.527 0.473
E85 Amyloidosis
0.000 0.530 0.470
E46 Unspecified protein-energy malnutrition
0.000 0.531 0.468
E34 Other endocrine disorders
0.000 0.533 0.467
E05.9 Thyrotoxicosis, unspecified
0.001 0.534 0.465
D58 Other hereditary haemolytic anaemias
0.000 0.535 0.464
E11.2 With renal complications
0.000 0.538 0.462
D82.9 Immunodeficiency associated with major defect, unspecified
0.000 0.539 0.461
D82.8 Immunodeficiency associated with other specified major defects
0.000 0.539 0.461
D82.4 Hyperimmunoglobulin E [IgE] syndrome
0.000 0.539 0.461
D82.3 Immunodeficiency following hereditary defective response to Epstein-Barr virus
0.000 0.539 0.461
D82.2 Immunodeficiency with short-limbed stature
0.000 0.539 0.461
D82.0 Wiskott-Aldrich syndrome
0.000 0.539 0.461
D50 Iron deficiency anaemia
0.000 0.545 0.455
D80.4 Selective deficiency of immunoglobulin M [IgM]
0.000 0.545 0.455
E13.3 With ophthalmic complications
0.000 0.545 0.455
E88.0 Disorders of plasma-protein metabolism, not elsewhere classified
0.000 0.550 0.450
D84.1 Defects in the complement system
0.000 0.559 0.440
D52 Folate deficiency anaemia
0.000 0.560 0.440
E20 Hypoparathyroidism
0.000 0.561 0.439
E06.3 Autoimmune thyroiditis
0.015 0.563 0.422
D76.2 Haemophagocytic syndrome, infection-associated
0.000 0.563 0.437
D76.1 Haemophagocytic lymphohistiocytosis
0.000 0.563 0.437
D76.0 Langerhans' cell histiocytosis, not elsewhere classified
0.000 0.563 0.437
E04 Other non-toxic goitre
0.006 0.565 0.430
D82.1 Di George's syndrome
0.000 0.570 0.430
E51.2 Wernicke's encephalopathy
0.000 0.573 0.426
D69.6 Thrombocytopenia, unspecified
0.000 0.574 0.426
E06.1 Subacute thyroiditis
0.031 0.579 0.390
D69.2 Other nonthrombocytopenic purpura
0.000 0.581 0.419
E61 Deficiency of other nutrient elements
0.000 0.582 0.418
E34.9 Endocrine disorder, unspecified
0.000 0.582 0.418
E53.9 Vitamin B deficiency, unspecified
0.000 0.585 0.415
E85.4 Organ-limited amyloidosis
0.000 0.586 0.414
E07.8 Other specified disorders of thyroid
0.046 0.586 0.369
E27.3 Drug-induced adrenocortical insufficiency
0.000 0.587 0.413
K90 Intestinal malabsorption
0.000 0.589 0.411
E51.9 Thiamine deficiency, unspecified
0.000 0.589 0.411
E51.8 Other manifestations of thiamine deficiency
0.000 0.589 0.411
E51.1 Beriberi
0.000 0.589 0.411
E79 Disorders of purine and pyrimidine metabolism
0.000 0.589 0.411
D69.5 Secondary thrombocytopenia
0.000 0.590 0.410
E70 Disorders of aromatic amino-acid metabolism
0.000 0.593 0.406
E25 Adrenogenital disorders
0.000 0.594 0.406
D84.8 Other specified immunodeficiencies
0.000 0.595 0.405
D84.0 Lymphocyte function antigen-1 [LFA-1] defect
0.000 0.595 0.405
E06.5 Other chronic thyroiditis
0.032 0.599 0.370
E50.9 Vitamin A deficiency, unspecified
0.000 0.599 0.400
E50.8 Other manifestations of vitamin A deficiency
0.000 0.599 0.400
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.599 0.400
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.599 0.400
E50.5 Vitamin A deficiency with night blindness
0.000 0.599 0.400
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.599 0.400
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.599 0.400
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.599 0.400
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.599 0.400
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.599 0.400
E63.9 Nutritional deficiency, unspecified
0.000 0.599 0.400
E63.8 Other specified nutritional deficiencies
0.000 0.599 0.400
E63.1 Imbalance of constituents of food intake
0.000 0.599 0.400
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.599 0.400
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.599 0.400
E64.8 Sequelae of other nutritional deficiencies
0.000 0.599 0.400
E64.3 Sequelae of rickets
0.000 0.599 0.400
E64.2 Sequelae of vitamin C deficiency
0.000 0.599 0.400
E64.1 Sequelae of vitamin A deficiency
0.000 0.599 0.400
E64.0 Sequelae of protein-energy malnutrition
0.000 0.599 0.400
E88.1 Lipodystrophy, not elsewhere classified
0.000 0.602 0.398
E07.1 Dyshormogenetic goitre
0.065 0.604 0.331
E07.0 Hypersecretion of calcitonin
0.065 0.604 0.331
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.606 0.394
E32 Diseases of thymus
0.000 0.606 0.394
E31 Polyglandular dysfunction
0.000 0.606 0.394
E30 Disorders of puberty, not elsewhere classified
0.000 0.606 0.394
E67 Other hyperalimentation
0.000 0.606 0.394
E68 Sequelae of hyperalimentation
0.000 0.606 0.394
E77 Disorders of glycoprotein metabolism
0.000 0.608 0.392
E76 Disorders of glycosaminoglycan metabolism
0.000 0.608 0.392
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.000 0.608 0.392
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.000 0.608 0.392
D89.8 Other specified disorders involving the immune mechanism, not elsewhere classified
0.000 0.608 0.391
E53.1 Pyridoxine deficiency
0.000 0.610 0.389
E53.0 Riboflavin deficiency
0.000 0.610 0.389
E83.8 Other disorders of mineral metabolism
0.000 0.612 0.387
E83.2 Disorders of zinc metabolism
0.000 0.612 0.387
E83.0 Disorders of copper metabolism
0.000 0.612 0.387
E88.9 Metabolic disorder, unspecified
0.000 0.612 0.387
E27.5 Adrenomedullary hyperfunction
0.000 0.613 0.387
E27.0 Other adrenocortical overactivity
0.000 0.613 0.387
D76.3 Other histiocytosis syndromes
0.000 0.614 0.386
E11.0 With coma
0.000 0.614 0.386
D55.9 Anaemia due to enzyme disorder, unspecified
0.000 0.619 0.381
D55.8 Other anaemias due to enzyme disorders
0.000 0.619 0.381
D55.3 Anaemia due to disorders of nucleotide metabolism
0.000 0.619 0.381
D55.2 Anaemia due to disorders of glycolytic enzymes
0.000 0.619 0.381
D55.1 Anaemia due to other disorders of glutathione metabolism
0.000 0.619 0.381
D55.0 Anaemia due to glucose-6-phosphate dehydrogenase [G6PD] deficiency
0.000 0.619 0.381
D89.9 Disorder involving the immune mechanism, unspecified
0.000 0.619 0.381
E27.2 Addisonian crisis
0.000 0.621 0.379
E34.0 Carcinoid syndrome
0.000 0.625 0.375
E83.9 Disorder of mineral metabolism, unspecified
0.000 0.629 0.371
D89.3 Immune reconstitution syndrome
0.000 0.630 0.370
D69.9 Haemorrhagic condition, unspecified
0.000 0.633 0.367
E88.3 Tumour lysis syndrome
0.000 0.633 0.367
E84 Cystic fibrosis
0.000 0.634 0.366
E56.9 Vitamin deficiency, unspecified
0.000 0.636 0.364
E56.8 Deficiency of other vitamins
0.000 0.636 0.364
E56.0 Deficiency of vitamin E
0.000 0.636 0.364
E27.8 Other specified disorders of adrenal gland
0.000 0.637 0.363
D57.8 Other sickle-cell disorders
0.000 0.637 0.363
D57.3 Sickle-cell trait
0.000 0.637 0.363
D57.2 Double heterozygous sickling disorders
0.000 0.637 0.363
D57.0 Sickle-cell anaemia with crisis
0.000 0.637 0.363
D69.8 Other specified haemorrhagic conditions
0.000 0.639 0.361
E20.9 Hypoparathyroidism, unspecified
0.000 0.640 0.360
E72 Other disorders of amino-acid metabolism
0.000 0.640 0.359
E04.0 Non-toxic diffuse goitre
0.003 0.643 0.355
D56 Thalassaemia
0.001 0.644 0.355
E66 Obesity
0.000 0.645 0.355
D89.1 Cryoglobulinaemia
0.000 0.645 0.355
E85.3 Secondary systemic amyloidosis
0.000 0.645 0.355
E44.1 Mild protein-energy malnutrition
0.000 0.646 0.354
E44.0 Moderate protein-energy malnutrition
0.000 0.646 0.354
E22 Hyperfunction of pituitary gland
0.000 0.651 0.349
D69.3 Idiopathic thrombocytopenic purpura
0.000 0.652 0.348
D58.2 Other haemoglobinopathies
0.000 0.657 0.343
D69.1 Qualitative platelet defects
0.000 0.659 0.341
D50.9 Iron deficiency anaemia, unspecified
0.000 0.659 0.341
E53.8 Deficiency of other specified B group vitamins
0.000 0.659 0.341
E74 Other disorders of carbohydrate metabolism
0.000 0.659 0.340
E04.9 Non-toxic goitre, unspecified
0.001 0.660 0.340
E85.8 Other amyloidosis
0.000 0.663 0.337
E85.2 Heredofamilial amyloidosis, unspecified
0.000 0.663 0.337
E85.1 Neuropathic heredofamilial amyloidosis
0.000 0.663 0.337
E85.0 Nonneuropathic heredofamilial amyloidosis
0.000 0.663 0.337
D57.1 Sickle-cell anaemia without crisis
0.000 0.663 0.337
E88.8 Other specified metabolic disorders
0.000 0.664 0.335
E34.5 Androgen resistance syndrome
0.000 0.665 0.335
E34.4 Constitutional tall stature
0.000 0.665 0.335
E34.2 Ectopic hormone secretion, not elsewhere classified
0.000 0.665 0.335
E34.1 Other hypersecretion of intestinal hormones
0.000 0.665 0.335
D58.8 Other specified hereditary haemolytic anaemias
0.000 0.667 0.333
D58.1 Hereditary elliptocytosis
0.000 0.667 0.333
D50.8 Other iron deficiency anaemias
0.000 0.669 0.331
D50.1 Sideropenic dysphagia
0.000 0.673 0.327
E29 Testicular dysfunction
0.000 0.674 0.326
K90.9 Intestinal malabsorption, unspecified
0.000 0.677 0.323
E24 Cushing's syndrome
0.000 0.678 0.322
E34.3 Short stature, not elsewhere classified
0.000 0.679 0.321
E85.9 Amyloidosis, unspecified
0.000 0.679 0.321
E73 Lactose intolerance
0.000 0.683 0.317
D52.8 Other folate deficiency anaemias
0.000 0.684 0.316
D52.1 Drug-induced folate deficiency anaemia
0.000 0.684 0.316
D52.0 Dietary folate deficiency anaemia
0.000 0.684 0.316
D69.4 Other primary thrombocytopenia
0.000 0.684 0.315
E20.8 Other hypoparathyroidism
0.000 0.685 0.315
E20.1 Pseudohypoparathyroidism
0.000 0.685 0.315
E20.0 Idiopathic hypoparathyroidism
0.000 0.685 0.315
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.000 0.686 0.314
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
0.000 0.686 0.314
E56.1 Deficiency of vitamin K
0.000 0.687 0.312
E04.8 Other specified non-toxic goitre
0.004 0.688 0.308
E70.3 Albinism
0.000 0.694 0.306
E27.4 Other and unspecified adrenocortical insufficiency
0.000 0.695 0.305
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.000 0.696 0.303
D89.0 Polyclonal hypergammaglobulinaemia
0.000 0.697 0.303
D58.9 Hereditary haemolytic anaemia, unspecified
0.000 0.698 0.302
E66.2 Extreme obesity with alveolar hypoventilation
0.000 0.699 0.301
E66.0 Obesity due to excess calories
0.000 0.699 0.301
E88.2 Lipomatosis, not elsewhere classified
0.000 0.699 0.300
E61.9 Deficiency of nutrient element, unspecified
0.000 0.700 0.300
E61.8 Deficiency of other specified nutrient elements
0.000 0.700 0.300
E61.7 Deficiency of multiple nutrient elements
0.000 0.700 0.300
E61.6 Vanadium deficiency
0.000 0.700 0.300
E61.5 Molybdenum deficiency
0.000 0.700 0.300
E61.4 Chromium deficiency
0.000 0.700 0.300
E61.3 Manganese deficiency
0.000 0.700 0.300
E61.0 Copper deficiency
0.000 0.700 0.300
K90.3 Pancreatic steatorrhoea
0.000 0.705 0.295
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.705 0.295
K90.1 Tropical sprue
0.000 0.705 0.295
E79.9 Disorder of purine and pyrimidine metabolism, unspecified
0.000 0.705 0.295
E79.8 Other disorders of purine and pyrimidine metabolism
0.000 0.705 0.295
E79.1 Lesch-Nyhan syndrome
0.000 0.705 0.295
E65 Localised adiposity
0.000 0.706 0.293
E70.9 Disorder of aromatic amino-acid metabolism, unspecified
0.000 0.708 0.291
E70.8 Other disorders of aromatic amino-acid metabolism
0.000 0.708 0.291
E70.2 Disorders of tyrosine metabolism
0.000 0.708 0.291
E70.1 Other hyperphenylalaninaemias
0.000 0.708 0.291
E70.0 Classical phenylketonuria
0.000 0.708 0.291
E25.9 Adrenogenital disorder, unspecified
0.000 0.708 0.291
E25.8 Other adrenogenital disorders
0.000 0.708 0.291
D58.0 Hereditary spherocytosis
0.000 0.709 0.291
E30.9 Disorder of puberty, unspecified
0.000 0.717 0.283
E30.8 Other disorders of puberty
0.000 0.717 0.283
E30.1 Precocious puberty
0.000 0.717 0.283
E30.0 Delayed puberty
0.000 0.717 0.283
E31.9 Polyglandular dysfunction, unspecified
0.000 0.717 0.283
E31.8 Other polyglandular dysfunction
0.000 0.717 0.283
E31.1 Polyglandular hyperfunction
0.000 0.717 0.283
E31.0 Autoimmune polyglandular failure
0.000 0.717 0.283
E32.9 Disease of thymus, unspecified
0.000 0.717 0.283
E32.8 Other diseases of thymus
0.000 0.717 0.283
E32.1 Abscess of thymus
0.000 0.717 0.283
E32.0 Persistent hyperplasia of thymus
0.000 0.717 0.283
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.717 0.283
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.717 0.283
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.717 0.283
E67.8 Other specified hyperalimentation
0.000 0.717 0.282
E67.3 Hypervitaminosis D
0.000 0.717 0.282
E67.2 Megavitamin-B6 syndrome
0.000 0.717 0.282
E67.1 Hypercarotenaemia
0.000 0.717 0.282
E67.0 Hypervitaminosis A
0.000 0.717 0.282
K90.8 Other intestinal malabsorption
0.000 0.717 0.283
E71.3 Disorders of fatty-acid metabolism
0.000 0.719 0.281
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified
0.000 0.719 0.281
E71.1 Other disorders of branched-chain amino-acid metabolism
0.000 0.719 0.281
E71.0 Maple-syrup-urine disease
0.000 0.719 0.281
E76.9 Disorder of glucosaminoglycan metabolism, unspecified
0.000 0.719 0.281
E76.8 Other disorders of glucosaminoglycan metabolism
0.000 0.719 0.281
E76.3 Mucopolysaccharidosis, unspecified
0.000 0.719 0.281
E76.2 Other mucopolysaccharidoses
0.000 0.719 0.281
E76.1 Mucopolysaccharidosis, type II
0.000 0.719 0.281
E76.0 Mucopolysaccharidosis, type I
0.000 0.719 0.281
E77.9 Disorder of glycoprotein metabolism, unspecified
0.000 0.719 0.281
E77.8 Other disorders of glycoprotein metabolism
0.000 0.719 0.281
E77.1 Defects in glycoprotein degradation
0.000 0.719 0.281
E77.0 Defects in posttranslational modification of lysosomal enzymes
0.000 0.719 0.281
E26 Hyperaldosteronism
0.000 0.720 0.279
D89.2 Hypergammaglobulinaemia, unspecified
0.000 0.721 0.279
E22.1 Hyperprolactinaemia
0.000 0.723 0.277
E86 Volume depletion
0.000 0.735 0.265
E27.9 Disorder of adrenal gland, unspecified
0.000 0.737 0.263
E84.8 Cystic fibrosis with other manifestations
0.000 0.737 0.263
E84.1 Cystic fibrosis with intestinal manifestations
0.000 0.737 0.263
E84.0 Cystic fibrosis with pulmonary manifestations
0.000 0.737 0.263
E61.2 Magnesium deficiency
0.000 0.738 0.262
E34.8 Other specified endocrine disorders
0.000 0.739 0.260
E72.9 Disorder of amino-acid metabolism, unspecified
0.000 0.742 0.258
E72.8 Other specified disorders of amino-acid metabolism
0.000 0.742 0.258
E72.5 Disorders of glycine metabolism
0.000 0.742 0.258
E72.4 Disorders of ornithine metabolism
0.000 0.742 0.258
E72.3 Disorders of lysine and hydroxylysine metabolism
0.000 0.742 0.258
E72.2 Disorders of urea cycle metabolism
0.000 0.742 0.258
E72.1 Disorders of sulphur-bearing amino-acid metabolism
0.000 0.742 0.258
D56.9 Thalassaemia, unspecified
0.001 0.745 0.255
D56.8 Other thalassaemias
0.001 0.745 0.255
D56.4 Hereditary persistence of foetal haemoglobin [HPFH]
0.001 0.745 0.255
D56.2 Delta-beta thalassaemia
0.001 0.745 0.255
D56.0 Alpha thalassaemia
0.001 0.745 0.255
E66.1 Drug-induced obesity
0.000 0.745 0.255
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.000 0.746 0.254
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.750 0.250
E22.8 Other hyperfunction of pituitary gland
0.000 0.750 0.250
E24.0 Pituitary-dependent Cushing's disease
0.000 0.751 0.249
D60-D64 Aplastic and other anaemias
0.000 0.753 0.247
E74.9 Disorder of carbohydrate metabolism, unspecified
0.000 0.756 0.244
E74.8 Other specified disorders of carbohydrate metabolism
0.000 0.756 0.244
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
0.000 0.756 0.244
E74.2 Disorders of galactose metabolism
0.000 0.756 0.244
E74.1 Disorders of fructose metabolism
0.000 0.756 0.244
E74.0 Glycogen storage disease
0.000 0.756 0.244
E80 Disorders of porphyrin and bilirubin metabolism
0.000 0.756 0.243
E22.0 Acromegaly and pituitary gigantism
0.000 0.758 0.241
D73 Diseases of spleen
0.000 0.761 0.239
E84.9 Cystic fibrosis, unspecified
0.000 0.763 0.237
E29.9 Testicular dysfunction, unspecified
0.000 0.766 0.234
E29.8 Other testicular dysfunction
0.000 0.766 0.234
E29.0 Testicular hyperfunction
0.000 0.766 0.234
S64.4 Injury of digital nerve of other finger
0.233 0.767 0.000
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.000 0.769 0.231
E24.3 Ectopic ACTH syndrome
0.000 0.769 0.231

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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