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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs2517497
log Bayes Factor = 72.2687
Chromosome 6   position 31,036,783  (GRCh37) Explore rs2517497 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E03.9 Hypothyroidism, unspecified
1.000 0.000 0.000
K90.0 Coeliac disease
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
R31 Unspecified haematuria
1.000 0.000 0.000
E10-E14 Diabetes mellitus
0.000 0.000 1.000
L40.9 Psoriasis, unspecified
0.000 0.000 1.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.001 0.999
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.002 0.998
E16.2 Hypoglycaemia, unspecified
0.000 0.002 0.998
E10.1 With ketoacidosis
0.000 0.002 0.998
E16 Other disorders of pancreatic internal secretion
0.000 0.002 0.998
E10.9 Without complications
0.000 0.003 0.997
E10.3 With ophthalmic complications
0.000 0.006 0.994
L40 Psoriasis
0.000 0.014 0.986
E00-E07 Disorders of thyroid gland
0.039 0.015 0.946
D86.9 Sarcoidosis, unspecified
0.000 0.026 0.974
D86 Sarcoidosis
0.000 0.027 0.973
L40.5 Arthropathic psoriasis
0.000 0.031 0.969
D80-D89 Certain disorders involving the immune mechanism
0.000 0.043 0.957
E05 Thyrotoxicosis [hyperthyroidism]
0.006 0.048 0.945
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.051 0.949
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.000 0.055 0.945
L40.0 Psoriasis vulgaris
0.000 0.060 0.940
D70-D77 Other diseases of blood and blood-forming organs
0.000 0.062 0.938
D70 Agranulocytosis
0.000 0.070 0.930
E11 Non-insulin-dependent diabetes mellitus
0.000 0.073 0.927
D86.1 Sarcoidosis of lymph nodes
0.000 0.102 0.898
E10.2 With renal complications
0.000 0.106 0.894
E10.8 With unspecified complications
0.000 0.107 0.893
D50-D53 Nutritional anaemias
0.000 0.117 0.883
E10.4 With neurological complications
0.000 0.140 0.860
E11.3 With ophthalmic complications
0.000 0.140 0.860
E11.5 With peripheral circulatory complications
0.000 0.144 0.856
D51 Vitamin B12 deficiency anaemia
0.000 0.144 0.856
E50-E64 Other nutritional deficiencies
0.000 0.149 0.851
E10.5 With peripheral circulatory complications
0.000 0.158 0.842
D72 Other disorders of white blood cells
0.000 0.159 0.841
E11.4 With neurological complications
0.000 0.176 0.824
D86.0 Sarcoidosis of lung
0.000 0.180 0.820
E10.6 With other specified complications
0.000 0.185 0.815
E55 Vitamin D deficiency
0.000 0.195 0.805
D51.0 Vitamin B12 deficiency anaemia due to intrinsic factor deficiency
0.000 0.196 0.804
D80 Immunodeficiency with predominantly antibody defects
0.000 0.212 0.788
D55-D59 Haemolytic anaemias
0.000 0.221 0.779
D86.8 Sarcoidosis of other and combined sites
0.000 0.223 0.776
E55.9 Vitamin D deficiency, unspecified
0.000 0.228 0.772
D72.8 Other specified disorders of white blood cells
0.000 0.231 0.769
E03 Other hypothyroidism
0.409 0.233 0.357
D51.9 Vitamin B12 deficiency anaemia, unspecified
0.000 0.234 0.766
E10.0 With coma
0.000 0.235 0.764
D75 Other diseases of blood and blood-forming organs
0.000 0.236 0.764
E14 Unspecified diabetes mellitus
0.000 0.238 0.762
L40.4 Guttate psoriasis
0.000 0.238 0.761
D83 Common variable immunodeficiency
0.000 0.244 0.756
D86.3 Sarcoidosis of skin
0.000 0.246 0.754
D86.2 Sarcoidosis of lung with sarcoidosis of lymph nodes
0.000 0.254 0.746
D53 Other nutritional anaemias
0.000 0.255 0.745
E11.8 With unspecified complications
0.000 0.262 0.738
L40.1 Generalised pustular psoriasis
0.000 0.264 0.735
E11.1 With ketoacidosis
0.000 0.266 0.734
D59 Acquired haemolytic anaemia
0.000 0.267 0.733
E10.7 With multiple complications
0.000 0.283 0.717
E12 Malnutrition-related diabetes mellitus
0.000 0.283 0.717
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions
0.000 0.284 0.716
E15 Nondiabetic hypoglycaemic coma
0.000 0.284 0.716
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.284 0.716
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.284 0.716
E16.4 Abnormal secretion of gastrin
0.000 0.284 0.716
E16.3 Increased secretion of glucagon
0.000 0.284 0.716
L40.3 Pustulosis palmaris et plantaris
0.000 0.293 0.707
L40.2 Acrodermatitis continua
0.000 0.293 0.707
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.028 0.294 0.678
E00 Congenital iodine-deficiency syndrome
0.028 0.294 0.678
E40-E46 Malnutrition
0.000 0.310 0.690
D81 Combined immunodeficiencies
0.000 0.314 0.686
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.316 0.684
E16.1 Other hypoglycaemia
0.000 0.317 0.683
E05.5 Thyroid crisis or storm
0.005 0.318 0.678
E05.4 Thyrotoxicosis factitia
0.005 0.318 0.678
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.005 0.318 0.678
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.005 0.318 0.678
E02 Subclinical iodine-deficiency hypothyroidism
0.027 0.318 0.655
E13 Other specified diabetes mellitus
0.000 0.322 0.678
D74 Methaemoglobinaemia
0.000 0.328 0.672
D77 Other disorders of blood and blood-forming organs in diseases classified elsewhere
0.000 0.328 0.672
D71 Functional disorders of polymorphonuclear neutrophils
0.000 0.328 0.672
E06 Thyroiditis
0.020 0.328 0.651
E11.6 With other specified complications
0.000 0.330 0.670
E11.7 With multiple complications
0.000 0.335 0.665
D80.1 Nonfamilial hypogammaglobulinaemia
0.000 0.335 0.665
D59.9 Acquired haemolytic anaemia, unspecified
0.000 0.337 0.663
E14.3 With ophthalmic complications
0.000 0.338 0.662
D82 Immunodeficiency associated with other major defects
0.000 0.343 0.657
D75.9 Disease of blood and blood-forming organs, unspecified
0.000 0.347 0.653
D53.9 Nutritional anaemia, unspecified
0.000 0.354 0.646
E05.8 Other thyrotoxicosis
0.005 0.358 0.638
E51 Thiamine deficiency
0.000 0.360 0.640
D59.1 Other autoimmune haemolytic anaemias
0.000 0.364 0.636
D76 Certain diseases involving lymphoreticular tissue and reticulohistiocytic system
0.000 0.373 0.627
E53 Deficiency of other B group vitamins
0.000 0.376 0.624
D80.2 Selective deficiency of immunoglobulin A [IgA]
0.000 0.381 0.619
D51.8 Other vitamin B12 deficiency anaemias
0.000 0.386 0.614
D51.3 Other dietary vitamin B12 deficiency anaemia
0.000 0.386 0.614
D51.2 Transcobalamin II deficiency
0.000 0.386 0.614
D51.1 Vitamin B12 deficiency anaemia due to selective vitamin B12 malabsorption with proteinuria
0.000 0.386 0.614
D83.9 Common variable immunodeficiency, unspecified
0.000 0.388 0.612
D72.1 Eosinophilia
0.000 0.389 0.611
D80.3 Selective deficiency of immunoglobulin G [IgG] subclasses
0.000 0.389 0.611
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.390 0.610
E63 Other nutritional deficiencies
0.000 0.390 0.610
E50 Vitamin A deficiency
0.000 0.390 0.610
E60 Dietary zinc deficiency
0.000 0.390 0.610
E59 Dietary selenium deficiency
0.000 0.390 0.610
E52 Niacin deficiency [pellagra]
0.000 0.390 0.610
E14.8 With unspecified complications
0.000 0.395 0.605
D72.9 Disorder of white blood cells, unspecified
0.000 0.397 0.603
D72.0 Genetic anomalies of leukocytes
0.000 0.397 0.603
D75.0 Familial erythrocytosis
0.000 0.400 0.600
D69 Purpura and other haemorrhagic conditions
0.000 0.410 0.590
E14.1 With ketoacidosis
0.000 0.410 0.590
E54 Ascorbic acid deficiency
0.000 0.414 0.586
D66 Hereditary factor VIII deficiency
0.000 0.417 0.583
D84 Other immunodeficiencies
0.000 0.420 0.580
E55.0 Rickets, active
0.000 0.423 0.577
D65 Disseminated intravascular coagulation [defibrination syndrome]
0.000 0.427 0.573
E06.9 Thyroiditis, unspecified
0.009 0.433 0.559
D80.8 Other immunodeficiencies with predominantly antibody defects
0.000 0.435 0.565
D80.7 Transient hypogammaglobulinaemia of infancy
0.000 0.435 0.565
D80.6 Antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinaemia
0.000 0.435 0.565
D80.5 Immunodeficiency with increased immunoglobulin M [IgM]
0.000 0.435 0.565
D80.0 Hereditary hypogammaglobulinaemia
0.000 0.435 0.565
E58 Dietary calcium deficiency
0.000 0.438 0.561
E14.6 With other specified complications
0.000 0.439 0.561
D89 Other disorders involving the immune mechanism, not elsewhere classified
0.000 0.439 0.561
D55 Anaemia due to enzyme disorders
0.000 0.441 0.559
E56 Other vitamin deficiencies
0.000 0.445 0.555
D75.2 Essential thrombocytosis
0.000 0.446 0.554
E07 Other disorders of thyroid
0.056 0.446 0.498
E83.1 Disorders of iron metabolism
0.000 0.447 0.553
E65-E68 Obesity and other hyperalimentation
0.000 0.449 0.551
E03.5 Myxoedema coma
0.294 0.450 0.256
E03.4 Atrophy of thyroid (acquired)
0.294 0.450 0.256
E03.3 Postinfectious hypothyroidism
0.294 0.450 0.256
E20-E35 Disorders of other endocrine glands
0.000 0.450 0.549
E04 Other non-toxic goitre
0.002 0.453 0.544
E14.7 With multiple complications
0.000 0.453 0.546
E14.2 Withrenal complications
0.000 0.453 0.546
E14.0 With coma
0.000 0.453 0.546
E27.1 Primary adrenocortical insufficiency
0.000 0.458 0.542
E05.9 Thyrotoxicosis, unspecified
0.000 0.458 0.542
D83.8 Other common variable immunodeficiencies
0.000 0.458 0.542
D83.2 Common variable immunodeficiency with autoantibodies to B- or T-cells
0.000 0.458 0.542
D83.1 Common variable immunodeficiency with predominant immunoregulatory T-cell disorders
0.000 0.458 0.542
D83.0 Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function
0.000 0.458 0.542
E03.0 Congenital hypothyroidism with diffuse goitre
0.291 0.459 0.250
E27 Other disorders of adrenal gland
0.000 0.460 0.540
E70-E90 Metabolic disorders
0.000 0.464 0.536
D53.8 Other specified nutritional anaemias
0.000 0.466 0.534
D53.2 Scorbutic anaemia
0.000 0.466 0.534
D53.1 Other megaloblastic anaemias, not elsewhere classified
0.000 0.466 0.534
D53.0 Protein deficiency anaemia
0.000 0.466 0.534
E03.1 Congenital hypothyroidism without goitre
0.259 0.467 0.274
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.005 0.467 0.529
D57 Sickle-cell disorders
0.000 0.467 0.533
D80.9 Immunodeficiency with predominantly antibody defects, unspecified
0.000 0.472 0.528
E14.5 With peripheral circulatory complications
0.000 0.472 0.528
D59.8 Other acquired haemolytic anaemias
0.000 0.474 0.526
D59.6 Haemoglobinuria due to haemolysis from other external causes
0.000 0.474 0.526
D59.5 Paroxysmal nocturnal haemoglobinuria [Marchiafava-Micheli]
0.000 0.474 0.526
D59.4 Other nonautoimmune haemolytic anaemias
0.000 0.474 0.526
D59.3 Haemolytic-uraemic syndrome
0.000 0.474 0.526
D59.2 Drug-induced nonautoimmune haemolytic anaemia
0.000 0.474 0.526
D59.0 Drug-induced autoimmune haemolytic anaemia
0.000 0.474 0.526
E83 Disorders of mineral metabolism
0.000 0.476 0.524
L40.8 Other psoriasis
0.000 0.477 0.523
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.304 0.481 0.215
D58 Other hereditary haemolytic anaemias
0.000 0.483 0.517
E12.9 Without complications
0.000 0.486 0.514
E12.8 With unspecified complications
0.000 0.486 0.514
E12.7 With multiple complications
0.000 0.486 0.514
E12.6 With other specified complications
0.000 0.486 0.514
E12.5 With peripheral circulatory complications
0.000 0.486 0.514
E12.4 With neurological complications
0.000 0.486 0.514
E12.3 With ophthalmic complications
0.000 0.486 0.514
E12.2 With renal complications
0.000 0.486 0.514
E12.1 With ketoacidosis
0.000 0.486 0.514
E12.0 With coma
0.000 0.486 0.514
D75.8 Other specified diseases of blood and blood-forming organs
0.000 0.487 0.513
D67 Hereditary factor IX deficiency
0.000 0.490 0.510
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.020 0.494 0.486
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.020 0.494 0.486
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.020 0.494 0.486
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.020 0.494 0.486
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.020 0.494 0.486
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.020 0.494 0.486
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.020 0.494 0.486
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.020 0.494 0.486
D69.6 Thrombocytopenia, unspecified
0.000 0.495 0.505
E14.4 With neurological complications
0.000 0.497 0.503
K90 Intestinal malabsorption
0.000 0.505 0.495
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.505 0.495
E45 Retarded development following protein-energy malnutrition
0.000 0.505 0.495
E43 Unspecified severe protein-energy malnutrition
0.000 0.505 0.495
E42 Marasmic kwashiorkor
0.000 0.505 0.495
E41 Nutritional marasmus
0.000 0.505 0.495
E40 Kwashiorkor
0.000 0.505 0.495
D69.2 Other nonthrombocytopenic purpura
0.000 0.507 0.493
D81.9 Combined immunodeficiency, unspecified
0.000 0.508 0.492
D81.8 Other combined immunodeficiencies
0.000 0.508 0.492
D81.7 Major histocompatibility complex class II deficiency
0.000 0.508 0.492
D81.6 Major histocompatibility complex class I deficiency
0.000 0.508 0.492
D81.5 Purine nucleoside phosphorylase [PNP] deficiency
0.000 0.508 0.492
D81.4 Nezelof's syndrome
0.000 0.508 0.492
D81.3 Adenosine deaminase [ADA] deficiency
0.000 0.508 0.492
D81.2 Severe combined immunodeficiency [SCID] with low or normal B-cell numbers
0.000 0.508 0.492
D81.1 Severe combined immunodeficiency [SCID] with low T- and B-cell numbers
0.000 0.508 0.492
D81.0 Severe combined immunodeficiency [SCID] with reticular dysgenesis
0.000 0.508 0.492
E51.2 Wernicke's encephalopathy
0.000 0.511 0.489
E03.8 Other specified hypothyroidism
0.262 0.511 0.227
D69.5 Secondary thrombocytopenia
0.000 0.514 0.486
E13.8 With unspecified complications
0.000 0.514 0.486
E13.7 With multiple complications
0.000 0.514 0.486
E13.6 With other specified complications
0.000 0.514 0.486
E13.5 With peripheral circulatory complications
0.000 0.514 0.486
E13.4 With neurological complications
0.000 0.514 0.486
E13.2 With renal complications
0.000 0.514 0.486
E13.1 With ketoacidosis
0.000 0.514 0.486
E13.0 With coma
0.000 0.514 0.486
E88 Other metabolic disorders
0.000 0.515 0.485
E13.9 Without complications
0.000 0.515 0.485
D75.1 Secondary polycythaemia
0.000 0.517 0.483
D74.9 Methaemoglobinaemia, unspecified
0.000 0.518 0.482
D74.8 Other methaemoglobinaemias
0.000 0.518 0.482
D74.0 Congenital methaemoglobinaemia
0.000 0.518 0.482
E06.4 Drug-induced thyroiditis
0.015 0.518 0.467
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.015 0.518 0.467
E06.0 Acute thyroiditis
0.015 0.518 0.467
E53.9 Vitamin B deficiency, unspecified
0.000 0.520 0.480
D80.4 Selective deficiency of immunoglobulin M [IgM]
0.000 0.520 0.479
D50 Iron deficiency anaemia
0.000 0.522 0.478
E85 Amyloidosis
0.000 0.526 0.474
D82.9 Immunodeficiency associated with major defect, unspecified
0.000 0.529 0.471
D82.8 Immunodeficiency associated with other specified major defects
0.000 0.529 0.471
D82.4 Hyperimmunoglobulin E [IgE] syndrome
0.000 0.529 0.471
D82.3 Immunodeficiency following hereditary defective response to Epstein-Barr virus
0.000 0.529 0.471
D82.2 Immunodeficiency with short-limbed stature
0.000 0.529 0.471
D82.0 Wiskott-Aldrich syndrome
0.000 0.529 0.471
E46 Unspecified protein-energy malnutrition
0.000 0.532 0.468
E34 Other endocrine disorders
0.000 0.538 0.462
E51.9 Thiamine deficiency, unspecified
0.000 0.541 0.459
E51.8 Other manifestations of thiamine deficiency
0.000 0.541 0.459
E51.1 Beriberi
0.000 0.541 0.459
E04.0 Non-toxic diffuse goitre
0.001 0.545 0.454
D84.1 Defects in the complement system
0.000 0.546 0.454
D76.2 Haemophagocytic syndrome, infection-associated
0.000 0.550 0.450
D76.1 Haemophagocytic lymphohistiocytosis
0.000 0.550 0.450
D76.0 Langerhans' cell histiocytosis, not elsewhere classified
0.000 0.550 0.450
E13.3 With ophthalmic complications
0.000 0.552 0.448
E53.1 Pyridoxine deficiency
0.000 0.553 0.447
E53.0 Riboflavin deficiency
0.000 0.553 0.447
E06.3 Autoimmune thyroiditis
0.008 0.553 0.440
E88.0 Disorders of plasma-protein metabolism, not elsewhere classified
0.000 0.556 0.444
D69.3 Idiopathic thrombocytopenic purpura
0.000 0.557 0.443
D82.1 Di George's syndrome
0.000 0.558 0.442
E04.9 Non-toxic goitre, unspecified
0.000 0.561 0.439
E50.9 Vitamin A deficiency, unspecified
0.000 0.563 0.437
E50.8 Other manifestations of vitamin A deficiency
0.000 0.563 0.437
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.563 0.437
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.563 0.437
E50.5 Vitamin A deficiency with night blindness
0.000 0.563 0.437
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.563 0.437
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.563 0.437
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.563 0.437
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.563 0.437
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.563 0.437
E63.9 Nutritional deficiency, unspecified
0.000 0.563 0.437
E63.8 Other specified nutritional deficiencies
0.000 0.563 0.437
E63.1 Imbalance of constituents of food intake
0.000 0.563 0.437
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.563 0.437
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.563 0.437
E64.8 Sequelae of other nutritional deficiencies
0.000 0.563 0.437
E64.3 Sequelae of rickets
0.000 0.563 0.437
E64.2 Sequelae of vitamin C deficiency
0.000 0.563 0.437
E64.1 Sequelae of vitamin A deficiency
0.000 0.563 0.437
E64.0 Sequelae of protein-energy malnutrition
0.000 0.563 0.437
D69.9 Haemorrhagic condition, unspecified
0.000 0.564 0.436
E61 Deficiency of other nutrient elements
0.000 0.567 0.433
E20 Hypoparathyroidism
0.000 0.568 0.432
D52 Folate deficiency anaemia
0.000 0.569 0.431
E07.8 Other specified disorders of thyroid
0.028 0.571 0.402
D89.8 Other specified disorders involving the immune mechanism, not elsewhere classified
0.000 0.573 0.426
E85.4 Organ-limited amyloidosis
0.000 0.574 0.426
E53.8 Deficiency of other specified B group vitamins
0.000 0.576 0.424
D69.8 Other specified haemorrhagic conditions
0.000 0.577 0.423
E06.1 Subacute thyroiditis
0.016 0.582 0.402
E11.0 With coma
0.000 0.582 0.418
D89.9 Disorder involving the immune mechanism, unspecified
0.000 0.583 0.417
D84.8 Other specified immunodeficiencies
0.000 0.584 0.416
D84.0 Lymphocyte function antigen-1 [LFA-1] defect
0.000 0.584 0.416
E27.3 Drug-induced adrenocortical insufficiency
0.000 0.585 0.415
K90.9 Intestinal malabsorption, unspecified
0.000 0.586 0.414
E34.9 Endocrine disorder, unspecified
0.000 0.591 0.409
E25 Adrenogenital disorders
0.000 0.593 0.407
D76.3 Other histiocytosis syndromes
0.000 0.595 0.405
E79 Disorders of purine and pyrimidine metabolism
0.000 0.595 0.404
D89.3 Immune reconstitution syndrome
0.000 0.598 0.402
D55.9 Anaemia due to enzyme disorder, unspecified
0.000 0.599 0.401
D55.8 Other anaemias due to enzyme disorders
0.000 0.599 0.401
D55.3 Anaemia due to disorders of nucleotide metabolism
0.000 0.599 0.401
D55.2 Anaemia due to disorders of glycolytic enzymes
0.000 0.599 0.401
D55.1 Anaemia due to other disorders of glutathione metabolism
0.000 0.599 0.401
D55.0 Anaemia due to glucose-6-phosphate dehydrogenase [G6PD] deficiency
0.000 0.599 0.401
D69.1 Qualitative platelet defects
0.000 0.599 0.401
E70 Disorders of aromatic amino-acid metabolism
0.000 0.601 0.399
E56.9 Vitamin deficiency, unspecified
0.000 0.602 0.398
E56.8 Deficiency of other vitamins
0.000 0.602 0.398
E56.0 Deficiency of vitamin E
0.000 0.602 0.398
E06.5 Other chronic thyroiditis
0.017 0.602 0.381
E07.1 Dyshormogenetic goitre
0.040 0.603 0.357
E07.0 Hypersecretion of calcitonin
0.040 0.603 0.357
E11.2 With renal complications
0.000 0.604 0.395
E67 Other hyperalimentation
0.000 0.605 0.395
E68 Sequelae of hyperalimentation
0.000 0.605 0.395
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.606 0.394
E32 Diseases of thymus
0.000 0.606 0.394
E31 Polyglandular dysfunction
0.000 0.606 0.394
E30 Disorders of puberty, not elsewhere classified
0.000 0.606 0.394
E04.8 Other specified non-toxic goitre
0.002 0.608 0.390
E88.1 Lipodystrophy, not elsewhere classified
0.000 0.609 0.391
D89.1 Cryoglobulinaemia
0.000 0.612 0.387
E27.5 Adrenomedullary hyperfunction
0.000 0.613 0.387
E27.0 Other adrenocortical overactivity
0.000 0.613 0.387
E77 Disorders of glycoprotein metabolism
0.000 0.615 0.385
E76 Disorders of glycosaminoglycan metabolism
0.000 0.615 0.385
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.000 0.615 0.385
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.000 0.615 0.385
E27.2 Addisonian crisis
0.000 0.616 0.384
D58.2 Other haemoglobinopathies
0.000 0.617 0.383
D57.8 Other sickle-cell disorders
0.000 0.618 0.382
D57.3 Sickle-cell trait
0.000 0.618 0.382
D57.2 Double heterozygous sickling disorders
0.000 0.618 0.382
D57.0 Sickle-cell anaemia with crisis
0.000 0.618 0.382
E88.9 Metabolic disorder, unspecified
0.000 0.620 0.380
D50.9 Iron deficiency anaemia, unspecified
0.000 0.624 0.376
E83.8 Other disorders of mineral metabolism
0.000 0.624 0.376
E83.2 Disorders of zinc metabolism
0.000 0.624 0.376
E83.0 Disorders of copper metabolism
0.000 0.624 0.376
D69.4 Other primary thrombocytopenia
0.000 0.626 0.374
E66 Obesity
0.000 0.628 0.372
D58.8 Other specified hereditary haemolytic anaemias
0.000 0.629 0.371
D58.1 Hereditary elliptocytosis
0.000 0.629 0.371
E34.0 Carcinoid syndrome
0.000 0.630 0.370
E22 Hyperfunction of pituitary gland
0.000 0.635 0.365
E83.9 Disorder of mineral metabolism, unspecified
0.000 0.639 0.360
E84 Cystic fibrosis
0.000 0.640 0.360
E85.3 Secondary systemic amyloidosis
0.000 0.641 0.359
D57.1 Sickle-cell anaemia without crisis
0.000 0.644 0.356
E27.8 Other specified disorders of adrenal gland
0.000 0.645 0.355
K90.3 Pancreatic steatorrhoea
0.000 0.645 0.355
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.645 0.355
K90.1 Tropical sprue
0.000 0.645 0.355
E44.1 Mild protein-energy malnutrition
0.000 0.645 0.355
E44.0 Moderate protein-energy malnutrition
0.000 0.645 0.355
D56 Thalassaemia
0.001 0.646 0.353
E72 Other disorders of amino-acid metabolism
0.000 0.647 0.353
D58.0 Hereditary spherocytosis
0.000 0.651 0.349
E20.9 Hypoparathyroidism, unspecified
0.000 0.653 0.347
E88.3 Tumour lysis syndrome
0.000 0.653 0.346
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.000 0.656 0.344
E56.1 Deficiency of vitamin K
0.000 0.656 0.343
D50.1 Sideropenic dysphagia
0.000 0.657 0.343
K90.8 Other intestinal malabsorption
0.000 0.657 0.343
E85.8 Other amyloidosis
0.000 0.660 0.340
E85.2 Heredofamilial amyloidosis, unspecified
0.000 0.660 0.340
E85.1 Neuropathic heredofamilial amyloidosis
0.000 0.660 0.340
E85.0 Nonneuropathic heredofamilial amyloidosis
0.000 0.660 0.340
D58.9 Hereditary haemolytic anaemia, unspecified
0.000 0.660 0.339
D50.8 Other iron deficiency anaemias
0.000 0.665 0.335
D89.0 Polyclonal hypergammaglobulinaemia
0.000 0.669 0.331
E34.5 Androgen resistance syndrome
0.000 0.669 0.331
E34.4 Constitutional tall stature
0.000 0.669 0.331
E34.2 Ectopic hormone secretion, not elsewhere classified
0.000 0.669 0.331
E34.1 Other hypersecretion of intestinal hormones
0.000 0.669 0.331
E24 Cushing's syndrome
0.000 0.669 0.331
E88.8 Other specified metabolic disorders
0.000 0.670 0.330
D89.2 Hypergammaglobulinaemia, unspecified
0.000 0.671 0.328
E74 Other disorders of carbohydrate metabolism
0.000 0.672 0.328
E85.9 Amyloidosis, unspecified
0.000 0.672 0.328
E27.4 Other and unspecified adrenocortical insufficiency
0.000 0.679 0.321
E86 Volume depletion
0.000 0.680 0.320
E34.3 Short stature, not elsewhere classified
0.000 0.682 0.318
E29 Testicular dysfunction
0.000 0.682 0.318
E66.2 Extreme obesity with alveolar hypoventilation
0.000 0.682 0.318
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.000 0.686 0.314
E61.9 Deficiency of nutrient element, unspecified
0.000 0.689 0.310
E61.8 Deficiency of other specified nutrient elements
0.000 0.689 0.310
E61.7 Deficiency of multiple nutrient elements
0.000 0.689 0.310
E61.6 Vanadium deficiency
0.000 0.689 0.310
E61.5 Molybdenum deficiency
0.000 0.689 0.310
E61.4 Chromium deficiency
0.000 0.689 0.310
E61.3 Manganese deficiency
0.000 0.689 0.310
E61.0 Copper deficiency
0.000 0.689 0.310
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
0.000 0.690 0.310
E20.8 Other hypoparathyroidism
0.000 0.690 0.310
E20.1 Pseudohypoparathyroidism
0.000 0.690 0.310
E20.0 Idiopathic hypoparathyroidism
0.000 0.690 0.310
E66.0 Obesity due to excess calories
0.000 0.691 0.309
D52.8 Other folate deficiency anaemias
0.000 0.691 0.309
D52.1 Drug-induced folate deficiency anaemia
0.000 0.691 0.309
D52.0 Dietary folate deficiency anaemia
0.000 0.691 0.309
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.000 0.695 0.305
E22.1 Hyperprolactinaemia
0.000 0.696 0.304
E70.3 Albinism
0.000 0.699 0.301
E73 Lactose intolerance
0.000 0.699 0.301
E25.9 Adrenogenital disorder, unspecified
0.000 0.708 0.292
E25.8 Other adrenogenital disorders
0.000 0.708 0.292
E79.9 Disorder of purine and pyrimidine metabolism, unspecified
0.000 0.710 0.290
E79.8 Other disorders of purine and pyrimidine metabolism
0.000 0.710 0.290
E79.1 Lesch-Nyhan syndrome
0.000 0.710 0.290
E88.2 Lipomatosis, not elsewhere classified
0.000 0.713 0.287
E70.9 Disorder of aromatic amino-acid metabolism, unspecified
0.000 0.713 0.286
E70.8 Other disorders of aromatic amino-acid metabolism
0.000 0.713 0.286
E70.2 Disorders of tyrosine metabolism
0.000 0.713 0.286
E70.1 Other hyperphenylalaninaemias
0.000 0.713 0.286
E70.0 Classical phenylketonuria
0.000 0.713 0.286
E67.8 Other specified hyperalimentation
0.000 0.716 0.283
E67.3 Hypervitaminosis D
0.000 0.716 0.283
E67.2 Megavitamin-B6 syndrome
0.000 0.716 0.283
E67.1 Hypercarotenaemia
0.000 0.716 0.283
E67.0 Hypervitaminosis A
0.000 0.716 0.283
E30.9 Disorder of puberty, unspecified
0.000 0.717 0.283
E30.8 Other disorders of puberty
0.000 0.717 0.283
E30.1 Precocious puberty
0.000 0.717 0.283
E30.0 Delayed puberty
0.000 0.717 0.283
E31.9 Polyglandular dysfunction, unspecified
0.000 0.717 0.283
E31.8 Other polyglandular dysfunction
0.000 0.717 0.283
E31.1 Polyglandular hyperfunction
0.000 0.717 0.283
E31.0 Autoimmune polyglandular failure
0.000 0.717 0.283
E32.9 Disease of thymus, unspecified
0.000 0.717 0.283
E32.8 Other diseases of thymus
0.000 0.717 0.283
E32.1 Abscess of thymus
0.000 0.717 0.283
E32.0 Persistent hyperplasia of thymus
0.000 0.717 0.283
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.717 0.283
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.717 0.283
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.717 0.283
D60-D64 Aplastic and other anaemias
0.000 0.721 0.279
E71.3 Disorders of fatty-acid metabolism
0.000 0.724 0.276
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified
0.000 0.724 0.276
E71.1 Other disorders of branched-chain amino-acid metabolism
0.000 0.724 0.276
E71.0 Maple-syrup-urine disease
0.000 0.724 0.276
E76.9 Disorder of glucosaminoglycan metabolism, unspecified
0.000 0.724 0.276
E76.8 Other disorders of glucosaminoglycan metabolism
0.000 0.724 0.276
E76.3 Mucopolysaccharidosis, unspecified
0.000 0.724 0.276
E76.2 Other mucopolysaccharidoses
0.000 0.724 0.276
E76.1 Mucopolysaccharidosis, type II
0.000 0.724 0.276
E76.0 Mucopolysaccharidosis, type I
0.000 0.724 0.276
E77.9 Disorder of glycoprotein metabolism, unspecified
0.000 0.724 0.276
E77.8 Other disorders of glycoprotein metabolism
0.000 0.724 0.276
E77.1 Defects in glycoprotein degradation
0.000 0.724 0.276
E77.0 Defects in posttranslational modification of lysosomal enzymes
0.000 0.724 0.276
E26 Hyperaldosteronism
0.000 0.725 0.275
E61.2 Magnesium deficiency
0.000 0.727 0.273
S64.4 Injury of digital nerve of other finger
0.273 0.727 0.000
E65 Localised adiposity
0.000 0.729 0.271
E04.1 Non-toxic single thyroid nodule
0.001 0.729 0.270
E66.1 Drug-induced obesity
0.000 0.733 0.267
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.738 0.262
E22.8 Other hyperfunction of pituitary gland
0.000 0.738 0.262
E34.8 Other specified endocrine disorders
0.000 0.739 0.260
E84.8 Cystic fibrosis with other manifestations
0.000 0.741 0.258
E84.1 Cystic fibrosis with intestinal manifestations
0.000 0.741 0.258
E84.0 Cystic fibrosis with pulmonary manifestations
0.000 0.741 0.258
E24.0 Pituitary-dependent Cushing's disease
0.000 0.743 0.257
D73 Diseases of spleen
0.000 0.746 0.254
D56.9 Thalassaemia, unspecified
0.001 0.746 0.253
D56.8 Other thalassaemias
0.001 0.746 0.253
D56.4 Hereditary persistence of foetal haemoglobin [HPFH]
0.001 0.746 0.253
D56.2 Delta-beta thalassaemia
0.001 0.746 0.253
D56.0 Alpha thalassaemia
0.001 0.746 0.253
E72.9 Disorder of amino-acid metabolism, unspecified
0.000 0.746 0.253
E72.8 Other specified disorders of amino-acid metabolism
0.000 0.746 0.253
E72.5 Disorders of glycine metabolism
0.000 0.746 0.253
E72.4 Disorders of ornithine metabolism
0.000 0.746 0.253
E72.3 Disorders of lysine and hydroxylysine metabolism
0.000 0.746 0.253
E72.2 Disorders of urea cycle metabolism
0.000 0.746 0.253
E72.1 Disorders of sulphur-bearing amino-acid metabolism
0.000 0.746 0.253
E66.8 Other obesity
0.000 0.750 0.250
E27.9 Disorder of adrenal gland, unspecified
0.000 0.750 0.249
E75.6 Lipid storage disorder, unspecified
0.000 0.753 0.247
E75.4 Neuronal ceroid lipofuscinosis
0.000 0.753 0.247
E75.3 Sphingolipidosis, unspecified
0.000 0.753 0.247
E75.2 Other sphingolipidosis
0.000 0.753 0.247
E75.1 Other gangliosidosis
0.000 0.753 0.247
E75.0 GM2 gangliosidosis
0.000 0.753 0.247
E14.9 Without complications
0.000 0.757 0.243
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.000 0.763 0.237
E24.3 Ectopic ACTH syndrome
0.000 0.763 0.237
E24.1 Nelson's syndrome
0.000 0.763 0.237
E74.9 Disorder of carbohydrate metabolism, unspecified
0.000 0.764 0.235
E74.8 Other specified disorders of carbohydrate metabolism
0.000 0.764 0.235

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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