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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs2517500
log Bayes Factor = 71.3558
Chromosome 6   position 31,033,509  (GRCh37) Explore rs2517500 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E03.9 Hypothyroidism, unspecified
1.000 0.000 0.000
K90.0 Coeliac disease
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
R31 Unspecified haematuria
1.000 0.000 0.000
L40.9 Psoriasis, unspecified
0.000 0.000 1.000
E10-E14 Diabetes mellitus
0.000 0.000 1.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.002 0.998
E10.1 With ketoacidosis
0.000 0.003 0.997
E10.9 Without complications
0.000 0.003 0.997
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.003 0.997
E16.2 Hypoglycaemia, unspecified
0.000 0.003 0.997
E16 Other disorders of pancreatic internal secretion
0.000 0.003 0.997
E10.3 With ophthalmic complications
0.000 0.006 0.994
L40 Psoriasis
0.000 0.008 0.992
L40.5 Arthropathic psoriasis
0.000 0.019 0.981
E00-E07 Disorders of thyroid gland
0.085 0.028 0.888
D86.9 Sarcoidosis, unspecified
0.000 0.030 0.970
D86 Sarcoidosis
0.000 0.031 0.969
D80-D89 Certain disorders involving the immune mechanism
0.000 0.052 0.948
L40.0 Psoriasis vulgaris
0.000 0.053 0.947
E11 Non-insulin-dependent diabetes mellitus
0.000 0.053 0.947
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.000 0.063 0.937
D70-D77 Other diseases of blood and blood-forming organs
0.000 0.071 0.929
D70 Agranulocytosis
0.000 0.078 0.922
E10.2 With renal complications
0.000 0.084 0.916
D50-D53 Nutritional anaemias
0.000 0.098 0.902
E05 Thyrotoxicosis [hyperthyroidism]
0.013 0.100 0.887
E11.5 With peripheral circulatory complications
0.000 0.104 0.896
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.107 0.892
D86.1 Sarcoidosis of lymph nodes
0.000 0.110 0.890
E10.8 With unspecified complications
0.000 0.111 0.889
D51 Vitamin B12 deficiency anaemia
0.000 0.116 0.884
E10.4 With neurological complications
0.000 0.140 0.860
E11.4 With neurological complications
0.000 0.140 0.860
E10.5 With peripheral circulatory complications
0.000 0.150 0.850
D51.0 Vitamin B12 deficiency anaemia due to intrinsic factor deficiency
0.000 0.151 0.849
D72 Other disorders of white blood cells
0.000 0.170 0.830
D86.0 Sarcoidosis of lung
0.000 0.171 0.829
E11.3 With ophthalmic complications
0.000 0.176 0.824
E50-E64 Other nutritional deficiencies
0.000 0.188 0.812
E10.6 With other specified complications
0.000 0.191 0.809
D51.9 Vitamin B12 deficiency anaemia, unspecified
0.000 0.210 0.790
E03 Other hypothyroidism
0.466 0.226 0.308
D75 Other diseases of blood and blood-forming organs
0.000 0.232 0.768
E11.8 With unspecified complications
0.000 0.232 0.768
D53 Other nutritional anaemias
0.000 0.233 0.767
L40.4 Guttate psoriasis
0.000 0.236 0.764
D86.8 Sarcoidosis of other and combined sites
0.000 0.236 0.764
L40.1 Generalised pustular psoriasis
0.000 0.237 0.763
E55 Vitamin D deficiency
0.000 0.241 0.759
E10.0 With coma
0.000 0.242 0.758
D80 Immunodeficiency with predominantly antibody defects
0.000 0.242 0.758
D72.8 Other specified disorders of white blood cells
0.000 0.248 0.752
D55-D59 Haemolytic anaemias
0.000 0.252 0.748
D86.3 Sarcoidosis of skin
0.000 0.254 0.746
D83 Common variable immunodeficiency
0.000 0.254 0.746
D86.2 Sarcoidosis of lung with sarcoidosis of lymph nodes
0.000 0.260 0.740
E11.1 With ketoacidosis
0.000 0.265 0.735
E14 Unspecified diabetes mellitus
0.000 0.268 0.732
E55.9 Vitamin D deficiency, unspecified
0.000 0.279 0.721
E11.6 With other specified complications
0.000 0.280 0.720
E10.7 With multiple complications
0.000 0.283 0.717
E12 Malnutrition-related diabetes mellitus
0.000 0.283 0.717
E15 Nondiabetic hypoglycaemic coma
0.000 0.285 0.715
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.285 0.714
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.285 0.714
E16.4 Abnormal secretion of gastrin
0.000 0.285 0.714
E16.3 Increased secretion of glucagon
0.000 0.285 0.714
E40-E46 Malnutrition
0.000 0.286 0.714
L40.3 Pustulosis palmaris et plantaris
0.000 0.289 0.711
L40.2 Acrodermatitis continua
0.000 0.289 0.711
E13 Other specified diabetes mellitus
0.000 0.296 0.704
D59 Acquired haemolytic anaemia
0.000 0.301 0.699
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.061 0.303 0.636
E00 Congenital iodine-deficiency syndrome
0.061 0.303 0.636
D81 Combined immunodeficiencies
0.000 0.320 0.680
E11.7 With multiple complications
0.000 0.321 0.679
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.324 0.676
E16.1 Other hypoglycaemia
0.000 0.325 0.675
D53.9 Nutritional anaemia, unspecified
0.000 0.330 0.670
E02 Subclinical iodine-deficiency hypothyroidism
0.059 0.330 0.611
E83.1 Disorders of iron metabolism
0.000 0.333 0.667
D74 Methaemoglobinaemia
0.000 0.334 0.666
D77 Other disorders of blood and blood-forming organs in diseases classified elsewhere
0.000 0.334 0.666
D71 Functional disorders of polymorphonuclear neutrophils
0.000 0.334 0.666
E06 Thyroiditis
0.044 0.337 0.618
D75.9 Disease of blood and blood-forming organs, unspecified
0.000 0.338 0.662
D82 Immunodeficiency associated with other major defects
0.000 0.351 0.649
E05.5 Thyroid crisis or storm
0.010 0.355 0.636
E05.4 Thyrotoxicosis factitia
0.010 0.355 0.636
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.010 0.355 0.636
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.010 0.355 0.636
E70-E90 Metabolic disorders
0.000 0.364 0.636
D51.8 Other vitamin B12 deficiency anaemias
0.000 0.366 0.634
D51.3 Other dietary vitamin B12 deficiency anaemia
0.000 0.366 0.634
D51.2 Transcobalamin II deficiency
0.000 0.366 0.634
D51.1 Vitamin B12 deficiency anaemia due to selective vitamin B12 malabsorption with proteinuria
0.000 0.366 0.634
D59.9 Acquired haemolytic anaemia, unspecified
0.000 0.371 0.629
E83 Disorders of mineral metabolism
0.000 0.372 0.628
D80.1 Nonfamilial hypogammaglobulinaemia
0.000 0.374 0.626
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions
0.000 0.381 0.619
D72.1 Eosinophilia
0.000 0.383 0.617
D76 Certain diseases involving lymphoreticular tissue and reticulohistiocytic system
0.000 0.385 0.615
E14.3 With ophthalmic complications
0.000 0.390 0.610
E51 Thiamine deficiency
0.000 0.391 0.609
E05.8 Other thyrotoxicosis
0.009 0.397 0.593
D83.9 Common variable immunodeficiency, unspecified
0.000 0.399 0.601
D75.0 Familial erythrocytosis
0.000 0.400 0.600
D59.1 Other autoimmune haemolytic anaemias
0.000 0.402 0.598
E14.8 With unspecified complications
0.000 0.404 0.596
D72.9 Disorder of white blood cells, unspecified
0.000 0.405 0.595
D72.0 Genetic anomalies of leukocytes
0.000 0.405 0.595
D80.2 Selective deficiency of immunoglobulin A [IgA]
0.000 0.409 0.591
D80.3 Selective deficiency of immunoglobulin G [IgG] subclasses
0.000 0.415 0.585
E20-E35 Disorders of other endocrine glands
0.000 0.416 0.584
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.418 0.582
E63 Other nutritional deficiencies
0.000 0.418 0.582
E50 Vitamin A deficiency
0.000 0.418 0.582
E60 Dietary zinc deficiency
0.000 0.418 0.582
E59 Dietary selenium deficiency
0.000 0.418 0.582
E52 Niacin deficiency [pellagra]
0.000 0.418 0.582
E88 Other metabolic disorders
0.000 0.423 0.577
E27.1 Primary adrenocortical insufficiency
0.000 0.425 0.575
E53 Deficiency of other B group vitamins
0.000 0.426 0.574
E27 Other disorders of adrenal gland
0.000 0.426 0.574
D75.2 Essential thrombocytosis
0.000 0.428 0.572
D84 Other immunodeficiencies
0.000 0.430 0.570
E14.1 With ketoacidosis
0.000 0.436 0.564
E07 Other disorders of thyroid
0.103 0.439 0.458
E54 Ascorbic acid deficiency
0.000 0.442 0.558
E14.6 With other specified complications
0.000 0.443 0.557
E06.9 Thyroiditis, unspecified
0.018 0.444 0.538
E03.5 Myxoedema coma
0.334 0.445 0.221
E03.4 Atrophy of thyroid (acquired)
0.334 0.445 0.221
E03.3 Postinfectious hypothyroidism
0.334 0.445 0.221
E85 Amyloidosis
0.000 0.446 0.554
D53.8 Other specified nutritional anaemias
0.000 0.450 0.550
D53.2 Scorbutic anaemia
0.000 0.450 0.550
D53.1 Other megaloblastic anaemias, not elsewhere classified
0.000 0.450 0.550
D53.0 Protein deficiency anaemia
0.000 0.450 0.550
E03.0 Congenital hypothyroidism with diffuse goitre
0.332 0.453 0.214
E55.0 Rickets, active
0.000 0.456 0.544
D80.8 Other immunodeficiencies with predominantly antibody defects
0.000 0.456 0.544
D80.7 Transient hypogammaglobulinaemia of infancy
0.000 0.456 0.544
D80.6 Antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinaemia
0.000 0.456 0.544
D80.5 Immunodeficiency with increased immunoglobulin M [IgM]
0.000 0.456 0.544
D80.0 Hereditary hypogammaglobulinaemia
0.000 0.456 0.544
D55 Anaemia due to enzyme disorders
0.000 0.464 0.536
D83.8 Other common variable immunodeficiencies
0.000 0.465 0.535
D83.2 Common variable immunodeficiency with autoantibodies to B- or T-cells
0.000 0.465 0.535
D83.1 Common variable immunodeficiency with predominant immunoregulatory T-cell disorders
0.000 0.465 0.535
D83.0 Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function
0.000 0.465 0.535
E58 Dietary calcium deficiency
0.000 0.466 0.534
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.350 0.467 0.183
E03.1 Congenital hypothyroidism without goitre
0.296 0.468 0.236
E11.2 With renal complications
0.000 0.470 0.530
E13.9 Without complications
0.000 0.471 0.529
E56 Other vitamin deficiencies
0.000 0.471 0.528
D50 Iron deficiency anaemia
0.000 0.473 0.527
E14.7 With multiple complications
0.000 0.475 0.525
E14.2 Withrenal complications
0.000 0.475 0.525
E14.0 With coma
0.000 0.475 0.525
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.009 0.477 0.514
E88.0 Disorders of plasma-protein metabolism, not elsewhere classified
0.000 0.477 0.523
D89 Other disorders involving the immune mechanism, not elsewhere classified
0.000 0.480 0.520
L40.8 Other psoriasis
0.000 0.480 0.519
E12.9 Without complications
0.000 0.486 0.514
E12.8 With unspecified complications
0.000 0.486 0.514
E12.7 With multiple complications
0.000 0.486 0.514
E12.6 With other specified complications
0.000 0.486 0.514
E12.5 With peripheral circulatory complications
0.000 0.486 0.514
E12.4 With neurological complications
0.000 0.486 0.514
E12.3 With ophthalmic complications
0.000 0.486 0.514
E12.2 With renal complications
0.000 0.486 0.514
E12.1 With ketoacidosis
0.000 0.486 0.514
E12.0 With coma
0.000 0.486 0.514
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.488 0.512
E45 Retarded development following protein-energy malnutrition
0.000 0.488 0.512
E43 Unspecified severe protein-energy malnutrition
0.000 0.488 0.512
E42 Marasmic kwashiorkor
0.000 0.488 0.512
E41 Nutritional marasmus
0.000 0.488 0.512
E40 Kwashiorkor
0.000 0.488 0.512
E46 Unspecified protein-energy malnutrition
0.000 0.489 0.511
D57 Sickle-cell disorders
0.000 0.490 0.510
E65-E68 Obesity and other hyperalimentation
0.000 0.493 0.507
D80.9 Immunodeficiency with predominantly antibody defects, unspecified
0.000 0.494 0.506
E13.8 With unspecified complications
0.000 0.495 0.505
E13.7 With multiple complications
0.000 0.495 0.505
E13.6 With other specified complications
0.000 0.495 0.505
E13.5 With peripheral circulatory complications
0.000 0.495 0.505
E13.4 With neurological complications
0.000 0.495 0.505
E13.2 With renal complications
0.000 0.495 0.505
E13.1 With ketoacidosis
0.000 0.495 0.505
E13.0 With coma
0.000 0.495 0.505
E14.5 With peripheral circulatory complications
0.000 0.495 0.505
D75.1 Secondary polycythaemia
0.000 0.498 0.502
D59.8 Other acquired haemolytic anaemias
0.000 0.499 0.501
D59.6 Haemoglobinuria due to haemolysis from other external causes
0.000 0.499 0.501
D59.5 Paroxysmal nocturnal haemoglobinuria [Marchiafava-Micheli]
0.000 0.499 0.501
D59.4 Other nonautoimmune haemolytic anaemias
0.000 0.499 0.501
D59.3 Haemolytic-uraemic syndrome
0.000 0.499 0.501
D59.2 Drug-induced nonautoimmune haemolytic anaemia
0.000 0.499 0.501
D59.0 Drug-induced autoimmune haemolytic anaemia
0.000 0.499 0.501
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.044 0.500 0.456
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.044 0.500 0.456
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.044 0.500 0.456
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.044 0.500 0.456
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.044 0.500 0.456
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.044 0.500 0.456
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.044 0.500 0.456
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.044 0.500 0.456
E34 Other endocrine disorders
0.000 0.501 0.499
D66 Hereditary factor VIII deficiency
0.000 0.502 0.498
E03.8 Other specified hypothyroidism
0.305 0.504 0.191
D75.8 Other specified diseases of blood and blood-forming organs
0.000 0.506 0.494
E85.4 Organ-limited amyloidosis
0.000 0.506 0.494
D65 Disseminated intravascular coagulation [defibrination syndrome]
0.000 0.507 0.493
D81.9 Combined immunodeficiency, unspecified
0.000 0.513 0.487
D81.8 Other combined immunodeficiencies
0.000 0.513 0.487
D81.7 Major histocompatibility complex class II deficiency
0.000 0.513 0.487
D81.6 Major histocompatibility complex class I deficiency
0.000 0.513 0.487
D81.5 Purine nucleoside phosphorylase [PNP] deficiency
0.000 0.513 0.487
D81.4 Nezelof's syndrome
0.000 0.513 0.487
D81.3 Adenosine deaminase [ADA] deficiency
0.000 0.513 0.487
D81.2 Severe combined immunodeficiency [SCID] with low or normal B-cell numbers
0.000 0.513 0.487
D81.1 Severe combined immunodeficiency [SCID] with low T- and B-cell numbers
0.000 0.513 0.487
D81.0 Severe combined immunodeficiency [SCID] with reticular dysgenesis
0.000 0.513 0.487
E14.4 With neurological complications
0.000 0.520 0.480
E79 Disorders of purine and pyrimidine metabolism
0.000 0.522 0.478
D74.9 Methaemoglobinaemia, unspecified
0.000 0.522 0.478
D74.8 Other methaemoglobinaemias
0.000 0.522 0.478
D74.0 Congenital methaemoglobinaemia
0.000 0.522 0.478
E06.4 Drug-induced thyroiditis
0.032 0.525 0.443
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.032 0.525 0.443
E06.0 Acute thyroiditis
0.032 0.525 0.443
E70 Disorders of aromatic amino-acid metabolism
0.000 0.527 0.473
D58 Other hereditary haemolytic anaemias
0.000 0.532 0.468
E20 Hypoparathyroidism
0.000 0.533 0.467
E05.9 Thyrotoxicosis, unspecified
0.001 0.534 0.465
D82.9 Immunodeficiency associated with major defect, unspecified
0.000 0.535 0.465
D82.8 Immunodeficiency associated with other specified major defects
0.000 0.535 0.465
D82.4 Hyperimmunoglobulin E [IgE] syndrome
0.000 0.535 0.465
D82.3 Immunodeficiency following hereditary defective response to Epstein-Barr virus
0.000 0.535 0.465
D82.2 Immunodeficiency with short-limbed stature
0.000 0.535 0.465
D82.0 Wiskott-Aldrich syndrome
0.000 0.535 0.465
E13.3 With ophthalmic complications
0.000 0.536 0.464
E51.2 Wernicke's encephalopathy
0.000 0.536 0.464
E88.1 Lipodystrophy, not elsewhere classified
0.000 0.537 0.462
D80.4 Selective deficiency of immunoglobulin M [IgM]
0.000 0.540 0.459
E77 Disorders of glycoprotein metabolism
0.000 0.544 0.456
E76 Disorders of glycosaminoglycan metabolism
0.000 0.544 0.456
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.000 0.544 0.456
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.000 0.544 0.456
D67 Hereditary factor IX deficiency
0.000 0.548 0.451
E88.9 Metabolic disorder, unspecified
0.000 0.550 0.450
E83.8 Other disorders of mineral metabolism
0.000 0.550 0.450
E83.2 Disorders of zinc metabolism
0.000 0.550 0.450
E83.0 Disorders of copper metabolism
0.000 0.550 0.450
D52 Folate deficiency anaemia
0.000 0.552 0.447
E34.9 Endocrine disorder, unspecified
0.000 0.554 0.446
D84.1 Defects in the complement system
0.000 0.555 0.445
D69 Purpura and other haemorrhagic conditions
0.000 0.556 0.444
D76.2 Haemophagocytic syndrome, infection-associated
0.000 0.559 0.441
D76.1 Haemophagocytic lymphohistiocytosis
0.000 0.559 0.441
D76.0 Langerhans' cell histiocytosis, not elsewhere classified
0.000 0.559 0.441
E53.9 Vitamin B deficiency, unspecified
0.000 0.561 0.439
E27.3 Drug-induced adrenocortical insufficiency
0.000 0.561 0.439
E51.9 Thiamine deficiency, unspecified
0.000 0.563 0.437
E51.8 Other manifestations of thiamine deficiency
0.000 0.563 0.437
E51.1 Beriberi
0.000 0.563 0.437
D82.1 Di George's syndrome
0.000 0.565 0.434
E25 Adrenogenital disorders
0.000 0.568 0.432
E61 Deficiency of other nutrient elements
0.000 0.568 0.432
E83.9 Disorder of mineral metabolism, unspecified
0.000 0.569 0.431
E04 Other non-toxic goitre
0.006 0.570 0.424
E06.3 Autoimmune thyroiditis
0.017 0.573 0.410
E88.3 Tumour lysis syndrome
0.000 0.574 0.426
D50.9 Iron deficiency anaemia, unspecified
0.000 0.574 0.426
E84 Cystic fibrosis
0.000 0.574 0.426
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.581 0.419
E32 Diseases of thymus
0.000 0.581 0.419
E31 Polyglandular dysfunction
0.000 0.581 0.419
E30 Disorders of puberty, not elsewhere classified
0.000 0.581 0.419
E72 Other disorders of amino-acid metabolism
0.000 0.581 0.418
E85.3 Secondary systemic amyloidosis
0.000 0.582 0.418
E07.8 Other specified disorders of thyroid
0.052 0.582 0.366
E50.9 Vitamin A deficiency, unspecified
0.000 0.582 0.417
E50.8 Other manifestations of vitamin A deficiency
0.000 0.582 0.417
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.582 0.417
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.582 0.417
E50.5 Vitamin A deficiency with night blindness
0.000 0.582 0.417
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.582 0.417
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.582 0.417
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.582 0.417
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.582 0.417
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.582 0.417
E63.9 Nutritional deficiency, unspecified
0.000 0.582 0.417
E63.8 Other specified nutritional deficiencies
0.000 0.582 0.417
E63.1 Imbalance of constituents of food intake
0.000 0.582 0.417
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.582 0.417
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.582 0.417
E64.8 Sequelae of other nutritional deficiencies
0.000 0.582 0.417
E64.3 Sequelae of rickets
0.000 0.582 0.417
E64.2 Sequelae of vitamin C deficiency
0.000 0.582 0.417
E64.1 Sequelae of vitamin A deficiency
0.000 0.582 0.417
E64.0 Sequelae of protein-energy malnutrition
0.000 0.582 0.417
E06.1 Subacute thyroiditis
0.035 0.585 0.380
E11.0 With coma
0.001 0.585 0.415
E53.1 Pyridoxine deficiency
0.000 0.588 0.412
E53.0 Riboflavin deficiency
0.000 0.588 0.412
E27.5 Adrenomedullary hyperfunction
0.000 0.588 0.412
E27.0 Other adrenocortical overactivity
0.000 0.588 0.412
D84.8 Other specified immunodeficiencies
0.000 0.591 0.409
D84.0 Lymphocyte function antigen-1 [LFA-1] defect
0.000 0.591 0.409
E34.0 Carcinoid syndrome
0.000 0.592 0.408
E27.2 Addisonian crisis
0.000 0.597 0.403
E07.1 Dyshormogenetic goitre
0.074 0.598 0.329
E07.0 Hypersecretion of calcitonin
0.074 0.598 0.329
K90 Intestinal malabsorption
0.000 0.601 0.399
E85.8 Other amyloidosis
0.000 0.603 0.397
E85.2 Heredofamilial amyloidosis, unspecified
0.000 0.603 0.397
E85.1 Neuropathic heredofamilial amyloidosis
0.000 0.603 0.397
E85.0 Nonneuropathic heredofamilial amyloidosis
0.000 0.603 0.397
E06.5 Other chronic thyroiditis
0.036 0.604 0.360
D89.8 Other specified disorders involving the immune mechanism, not elsewhere classified
0.000 0.606 0.394
E22 Hyperfunction of pituitary gland
0.000 0.610 0.390
E88.8 Other specified metabolic disorders
0.000 0.610 0.390
D76.3 Other histiocytosis syndromes
0.000 0.610 0.390
E74 Other disorders of carbohydrate metabolism
0.000 0.614 0.386
E27.8 Other specified disorders of adrenal gland
0.000 0.614 0.386
D50.8 Other iron deficiency anaemias
0.000 0.615 0.385
D55.9 Anaemia due to enzyme disorder, unspecified
0.000 0.615 0.384
D55.8 Other anaemias due to enzyme disorders
0.000 0.615 0.384
D55.3 Anaemia due to disorders of nucleotide metabolism
0.000 0.615 0.384
D55.2 Anaemia due to disorders of glycolytic enzymes
0.000 0.615 0.384
D55.1 Anaemia due to other disorders of glutathione metabolism
0.000 0.615 0.384
D55.0 Anaemia due to glucose-6-phosphate dehydrogenase [G6PD] deficiency
0.000 0.615 0.384
D89.9 Disorder involving the immune mechanism, unspecified
0.000 0.616 0.384
E20.9 Hypoparathyroidism, unspecified
0.000 0.618 0.382
E56.9 Vitamin deficiency, unspecified
0.000 0.621 0.379
E56.8 Deficiency of other vitamins
0.000 0.621 0.379
E56.0 Deficiency of vitamin E
0.000 0.621 0.379
D50.1 Sideropenic dysphagia
0.000 0.622 0.378
E85.9 Amyloidosis, unspecified
0.000 0.622 0.378
D89.3 Immune reconstitution syndrome
0.000 0.627 0.373
E53.8 Deficiency of other specified B group vitamins
0.000 0.630 0.370
D69.2 Other nonthrombocytopenic purpura
0.000 0.630 0.370
E73 Lactose intolerance
0.000 0.631 0.368
E44.1 Mild protein-energy malnutrition
0.000 0.633 0.367
E44.0 Moderate protein-energy malnutrition
0.000 0.633 0.367
D57.8 Other sickle-cell disorders
0.000 0.634 0.366
D57.3 Sickle-cell trait
0.000 0.634 0.366
D57.2 Double heterozygous sickling disorders
0.000 0.634 0.366
D57.0 Sickle-cell anaemia with crisis
0.000 0.634 0.366
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.000 0.634 0.365
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
0.000 0.635 0.365
E67 Other hyperalimentation
0.000 0.636 0.363
E68 Sequelae of hyperalimentation
0.000 0.636 0.363
D69.5 Secondary thrombocytopenia
0.000 0.638 0.361
D69.6 Thrombocytopenia, unspecified
0.000 0.639 0.361
D56 Thalassaemia
0.001 0.641 0.358
E34.5 Androgen resistance syndrome
0.000 0.642 0.358
E34.4 Constitutional tall stature
0.000 0.642 0.358
E34.2 Ectopic hormone secretion, not elsewhere classified
0.000 0.642 0.358
E34.1 Other hypersecretion of intestinal hormones
0.000 0.642 0.358
D89.1 Cryoglobulinaemia
0.000 0.642 0.357
E86 Volume depletion
0.000 0.643 0.357
E70.3 Albinism
0.000 0.644 0.356
E04.0 Non-toxic diffuse goitre
0.003 0.647 0.350
E88.2 Lipomatosis, not elsewhere classified
0.000 0.651 0.349
D58.2 Other haemoglobinopathies
0.000 0.654 0.346
E79.9 Disorder of purine and pyrimidine metabolism, unspecified
0.000 0.657 0.343
E79.8 Other disorders of purine and pyrimidine metabolism
0.000 0.657 0.343
E79.1 Lesch-Nyhan syndrome
0.000 0.657 0.343
E34.3 Short stature, not elsewhere classified
0.000 0.657 0.343
E29 Testicular dysfunction
0.000 0.658 0.342
E24 Cushing's syndrome
0.000 0.658 0.342
D57.1 Sickle-cell anaemia without crisis
0.000 0.660 0.340
E70.9 Disorder of aromatic amino-acid metabolism, unspecified
0.000 0.661 0.339
E70.8 Other disorders of aromatic amino-acid metabolism
0.000 0.661 0.339
E70.2 Disorders of tyrosine metabolism
0.000 0.661 0.339
E70.1 Other hyperphenylalaninaemias
0.000 0.661 0.339
E70.0 Classical phenylketonuria
0.000 0.661 0.339
D58.8 Other specified hereditary haemolytic anaemias
0.000 0.664 0.336
D58.1 Hereditary elliptocytosis
0.000 0.664 0.336
E20.8 Other hypoparathyroidism
0.000 0.665 0.335
E20.1 Pseudohypoparathyroidism
0.000 0.665 0.335
E20.0 Idiopathic hypoparathyroidism
0.000 0.665 0.335
E27.4 Other and unspecified adrenocortical insufficiency
0.000 0.665 0.334
E04.9 Non-toxic goitre, unspecified
0.001 0.665 0.334
E71.3 Disorders of fatty-acid metabolism
0.000 0.673 0.327
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified
0.000 0.673 0.327
E71.1 Other disorders of branched-chain amino-acid metabolism
0.000 0.673 0.327
E71.0 Maple-syrup-urine disease
0.000 0.673 0.327
E76.9 Disorder of glucosaminoglycan metabolism, unspecified
0.000 0.673 0.327
E76.8 Other disorders of glucosaminoglycan metabolism
0.000 0.673 0.327
E76.3 Mucopolysaccharidosis, unspecified
0.000 0.673 0.327
E76.2 Other mucopolysaccharidoses
0.000 0.673 0.327
E76.1 Mucopolysaccharidosis, type II
0.000 0.673 0.327
E76.0 Mucopolysaccharidosis, type I
0.000 0.673 0.327
E77.9 Disorder of glycoprotein metabolism, unspecified
0.000 0.673 0.327
E77.8 Other disorders of glycoprotein metabolism
0.000 0.673 0.327
E77.1 Defects in glycoprotein degradation
0.000 0.673 0.327
E77.0 Defects in posttranslational modification of lysosomal enzymes
0.000 0.673 0.327
E56.1 Deficiency of vitamin K
0.000 0.674 0.325
D69.9 Haemorrhagic condition, unspecified
0.000 0.676 0.324
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.000 0.677 0.322
D52.8 Other folate deficiency anaemias
0.000 0.679 0.321
D52.1 Drug-induced folate deficiency anaemia
0.000 0.679 0.321
D52.0 Dietary folate deficiency anaemia
0.000 0.679 0.321
D69.8 Other specified haemorrhagic conditions
0.000 0.681 0.319
K90.9 Intestinal malabsorption, unspecified
0.000 0.688 0.312
E25.9 Adrenogenital disorder, unspecified
0.000 0.690 0.310
E25.8 Other adrenogenital disorders
0.000 0.690 0.310
E61.9 Deficiency of nutrient element, unspecified
0.000 0.690 0.309
E61.8 Deficiency of other specified nutrient elements
0.000 0.690 0.309
E61.7 Deficiency of multiple nutrient elements
0.000 0.690 0.309
E61.6 Vanadium deficiency
0.000 0.690 0.309
E61.5 Molybdenum deficiency
0.000 0.690 0.309
E61.4 Chromium deficiency
0.000 0.690 0.309
E61.3 Manganese deficiency
0.000 0.690 0.309
E61.0 Copper deficiency
0.000 0.690 0.309
E22.1 Hyperprolactinaemia
0.000 0.690 0.310
E04.8 Other specified non-toxic goitre
0.005 0.691 0.304
D69.3 Idiopathic thrombocytopenic purpura
0.000 0.694 0.306
E84.8 Cystic fibrosis with other manifestations
0.000 0.694 0.306
E84.1 Cystic fibrosis with intestinal manifestations
0.000 0.694 0.306
E84.0 Cystic fibrosis with pulmonary manifestations
0.000 0.694 0.306
D89.0 Polyclonal hypergammaglobulinaemia
0.000 0.695 0.305
D58.9 Hereditary haemolytic anaemia, unspecified
0.000 0.696 0.304
D69.1 Qualitative platelet defects
0.000 0.699 0.301
E30.9 Disorder of puberty, unspecified
0.000 0.699 0.300
E30.8 Other disorders of puberty
0.000 0.699 0.300
E30.1 Precocious puberty
0.000 0.699 0.300
E30.0 Delayed puberty
0.000 0.699 0.300
E31.9 Polyglandular dysfunction, unspecified
0.000 0.699 0.300
E31.8 Other polyglandular dysfunction
0.000 0.699 0.300
E31.1 Polyglandular hyperfunction
0.000 0.699 0.300
E31.0 Autoimmune polyglandular failure
0.000 0.699 0.300
E32.9 Disease of thymus, unspecified
0.000 0.699 0.300
E32.8 Other diseases of thymus
0.000 0.699 0.300
E32.1 Abscess of thymus
0.000 0.699 0.300
E32.0 Persistent hyperplasia of thymus
0.000 0.699 0.300
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.699 0.300
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.699 0.300
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.699 0.300
E72.9 Disorder of amino-acid metabolism, unspecified
0.000 0.700 0.300
E72.8 Other specified disorders of amino-acid metabolism
0.000 0.700 0.300
E72.5 Disorders of glycine metabolism
0.000 0.700 0.300
E72.4 Disorders of ornithine metabolism
0.000 0.700 0.300
E72.3 Disorders of lysine and hydroxylysine metabolism
0.000 0.700 0.300
E72.2 Disorders of urea cycle metabolism
0.000 0.700 0.300
E72.1 Disorders of sulphur-bearing amino-acid metabolism
0.000 0.700 0.300
E26 Hyperaldosteronism
0.000 0.703 0.297
D58.0 Hereditary spherocytosis
0.000 0.706 0.293
E66 Obesity
0.000 0.707 0.293
K90.3 Pancreatic steatorrhoea
0.000 0.714 0.286
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.714 0.286
K90.1 Tropical sprue
0.000 0.714 0.286
D89.2 Hypergammaglobulinaemia, unspecified
0.000 0.719 0.280
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.720 0.280
E22.8 Other hyperfunction of pituitary gland
0.000 0.720 0.280
E80 Disorders of porphyrin and bilirubin metabolism
0.000 0.721 0.279
D69.4 Other primary thrombocytopenia
0.000 0.722 0.278
E74.9 Disorder of carbohydrate metabolism, unspecified
0.000 0.723 0.277
E74.8 Other specified disorders of carbohydrate metabolism
0.000 0.723 0.277
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
0.000 0.723 0.277
E74.2 Disorders of galactose metabolism
0.000 0.723 0.277
E74.1 Disorders of fructose metabolism
0.000 0.723 0.277
E74.0 Glycogen storage disease
0.000 0.723 0.277
E84.9 Cystic fibrosis, unspecified
0.000 0.724 0.276
E27.9 Disorder of adrenal gland, unspecified
0.000 0.726 0.274
K90.8 Other intestinal malabsorption
0.000 0.726 0.274
D60-D64 Aplastic and other anaemias
0.000 0.728 0.272
E65 Localised adiposity
0.000 0.729 0.270
E61.2 Magnesium deficiency
0.000 0.730 0.270
E22.0 Acromegaly and pituitary gigantism
0.000 0.730 0.270
E34.8 Other specified endocrine disorders
0.000 0.732 0.268
E73.8 Other lactose intolerance
0.000 0.735 0.264
E73.1 Secondary lactase deficiency
0.000 0.735 0.264
E73.0 Congenital lactase deficiency
0.000 0.735 0.264
E24.0 Pituitary-dependent Cushing's disease
0.000 0.736 0.264
E72.0 Disorders of amino-acid transport
0.000 0.738 0.262
E75.6 Lipid storage disorder, unspecified
0.000 0.738 0.262
E75.4 Neuronal ceroid lipofuscinosis
0.000 0.738 0.262
E75.3 Sphingolipidosis, unspecified
0.000 0.738 0.262
E75.1 Other gangliosidosis
0.000 0.738 0.262
E75.0 GM2 gangliosidosis
0.000 0.738 0.262
E67.8 Other specified hyperalimentation
0.000 0.739 0.261
E67.3 Hypervitaminosis D
0.000 0.739 0.261
E67.2 Megavitamin-B6 syndrome
0.000 0.739 0.261
E67.1 Hypercarotenaemia
0.000 0.739 0.261
E67.0 Hypervitaminosis A
0.000 0.739 0.261
D56.9 Thalassaemia, unspecified
0.001 0.742 0.257
D56.8 Other thalassaemias
0.001 0.742 0.257
D56.4 Hereditary persistence of foetal haemoglobin [HPFH]
0.001 0.742 0.257
D56.2 Delta-beta thalassaemia
0.001 0.742 0.257
D56.0 Alpha thalassaemia
0.001 0.742 0.257
E66.2 Extreme obesity with alveolar hypoventilation
0.000 0.751 0.249
E66.0 Obesity due to excess calories
0.000 0.752 0.248

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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