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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs2517523
log Bayes Factor = 71.8873
Chromosome 6   position 31,026,434  (GRCh37) Explore rs2517523 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E03.9 Hypothyroidism, unspecified
1.000 0.000 0.000
K90.0 Coeliac disease
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
R31 Unspecified haematuria
1.000 0.000 0.000
L40.9 Psoriasis, unspecified
0.000 0.000 1.000
E10-E14 Diabetes mellitus
0.000 0.001 0.999
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.002 0.998
E10.1 With ketoacidosis
0.000 0.002 0.998
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.003 0.997
E16.2 Hypoglycaemia, unspecified
0.000 0.003 0.997
E16 Other disorders of pancreatic internal secretion
0.000 0.003 0.997
E10.9 Without complications
0.000 0.005 0.995
E10.3 With ophthalmic complications
0.000 0.006 0.994
L40 Psoriasis
0.000 0.015 0.985
D86.9 Sarcoidosis, unspecified
0.000 0.015 0.985
D86 Sarcoidosis
0.000 0.015 0.985
E00-E07 Disorders of thyroid gland
0.040 0.021 0.939
D80-D89 Certain disorders involving the immune mechanism
0.000 0.023 0.977
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.000 0.029 0.971
L40.5 Arthropathic psoriasis
0.000 0.032 0.968
D70-D77 Other diseases of blood and blood-forming organs
0.000 0.036 0.964
D70 Agranulocytosis
0.000 0.042 0.958
E05 Thyrotoxicosis [hyperthyroidism]
0.007 0.056 0.938
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.058 0.941
L40.0 Psoriasis vulgaris
0.000 0.061 0.939
D50-D53 Nutritional anaemias
0.000 0.066 0.934
D51 Vitamin B12 deficiency anaemia
0.000 0.088 0.912
D86.1 Sarcoidosis of lymph nodes
0.000 0.091 0.909
E11 Non-insulin-dependent diabetes mellitus
0.000 0.099 0.901
E10.2 With renal complications
0.000 0.106 0.894
E10.8 With unspecified complications
0.000 0.107 0.893
D51.0 Vitamin B12 deficiency anaemia due to intrinsic factor deficiency
0.000 0.130 0.870
E10.4 With neurological complications
0.000 0.135 0.865
E50-E64 Other nutritional deficiencies
0.000 0.145 0.855
D72 Other disorders of white blood cells
0.000 0.149 0.851
E10.5 With peripheral circulatory complications
0.000 0.152 0.848
E11.5 With peripheral circulatory complications
0.000 0.166 0.834
D86.0 Sarcoidosis of lung
0.000 0.171 0.829
D51.9 Vitamin B12 deficiency anaemia, unspecified
0.000 0.185 0.815
E10.6 With other specified complications
0.000 0.186 0.814
E55 Vitamin D deficiency
0.000 0.192 0.808
D53 Other nutritional anaemias
0.000 0.201 0.799
D80 Immunodeficiency with predominantly antibody defects
0.000 0.202 0.798
E11.3 With ophthalmic complications
0.000 0.205 0.795
E11.4 With neurological complications
0.000 0.206 0.794
D75 Other diseases of blood and blood-forming organs
0.000 0.208 0.792
D86.8 Sarcoidosis of other and combined sites
0.000 0.215 0.785
D55-D59 Haemolytic anaemias
0.000 0.217 0.783
D72.8 Other specified disorders of white blood cells
0.000 0.223 0.777
E55.9 Vitamin D deficiency, unspecified
0.000 0.226 0.774
D83 Common variable immunodeficiency
0.000 0.229 0.771
E03 Other hypothyroidism
0.412 0.235 0.353
E10.0 With coma
0.000 0.236 0.764
D86.3 Sarcoidosis of skin
0.000 0.237 0.763
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions
0.000 0.238 0.762
L40.4 Guttate psoriasis
0.000 0.239 0.761
D86.2 Sarcoidosis of lung with sarcoidosis of lymph nodes
0.000 0.245 0.755
E14 Unspecified diabetes mellitus
0.000 0.255 0.745
D59 Acquired haemolytic anaemia
0.000 0.263 0.737
L40.1 Generalised pustular psoriasis
0.000 0.265 0.735
E11.8 With unspecified complications
0.000 0.269 0.731
E10.7 With multiple complications
0.000 0.283 0.717
E12 Malnutrition-related diabetes mellitus
0.000 0.283 0.716
E15 Nondiabetic hypoglycaemic coma
0.000 0.285 0.715
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.285 0.715
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.285 0.715
E16.4 Abnormal secretion of gastrin
0.000 0.285 0.715
E16.3 Increased secretion of glucagon
0.000 0.285 0.715
E11.1 With ketoacidosis
0.000 0.287 0.713
E13 Other specified diabetes mellitus
0.000 0.289 0.710
L40.3 Pustulosis palmaris et plantaris
0.000 0.293 0.706
L40.2 Acrodermatitis continua
0.000 0.293 0.706
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.029 0.298 0.673
E00 Congenital iodine-deficiency syndrome
0.029 0.298 0.673
D53.9 Nutritional anaemia, unspecified
0.000 0.298 0.702
D81 Combined immunodeficiencies
0.000 0.300 0.700
D74 Methaemoglobinaemia
0.000 0.309 0.691
D77 Other disorders of blood and blood-forming organs in diseases classified elsewhere
0.000 0.309 0.691
D71 Functional disorders of polymorphonuclear neutrophils
0.000 0.309 0.691
E40-E46 Malnutrition
0.000 0.312 0.688
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.317 0.683
E16.1 Other hypoglycaemia
0.000 0.318 0.681
E05.5 Thyroid crisis or storm
0.005 0.323 0.672
E05.4 Thyrotoxicosis factitia
0.005 0.323 0.672
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.005 0.323 0.672
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.005 0.323 0.672
D75.9 Disease of blood and blood-forming organs, unspecified
0.000 0.325 0.675
D82 Immunodeficiency associated with other major defects
0.000 0.330 0.670
E11.6 With other specified complications
0.000 0.333 0.667
D80.1 Nonfamilial hypogammaglobulinaemia
0.000 0.334 0.666
D59.9 Acquired haemolytic anaemia, unspecified
0.000 0.335 0.665
E06 Thyroiditis
0.021 0.335 0.644
E02 Subclinical iodine-deficiency hypothyroidism
0.029 0.340 0.631
D51.8 Other vitamin B12 deficiency anaemias
0.000 0.346 0.654
D51.3 Other dietary vitamin B12 deficiency anaemia
0.000 0.346 0.654
D51.2 Transcobalamin II deficiency
0.000 0.346 0.654
D51.1 Vitamin B12 deficiency anaemia due to selective vitamin B12 malabsorption with proteinuria
0.000 0.346 0.654
E11.7 With multiple complications
0.000 0.354 0.646
D76 Certain diseases involving lymphoreticular tissue and reticulohistiocytic system
0.000 0.355 0.645
E51 Thiamine deficiency
0.000 0.357 0.643
E53 Deficiency of other B group vitamins
0.000 0.357 0.643
D59.1 Other autoimmune haemolytic anaemias
0.000 0.361 0.639
E05.8 Other thyrotoxicosis
0.005 0.363 0.632
E14.3 With ophthalmic complications
0.000 0.367 0.633
D75.0 Familial erythrocytosis
0.000 0.372 0.628
D69 Purpura and other haemorrhagic conditions
0.000 0.373 0.627
D80.2 Selective deficiency of immunoglobulin A [IgA]
0.000 0.374 0.626
D83.9 Common variable immunodeficiency, unspecified
0.000 0.376 0.624
D66 Hereditary factor VIII deficiency
0.000 0.380 0.620
D80.3 Selective deficiency of immunoglobulin G [IgG] subclasses
0.000 0.382 0.618
D65 Disseminated intravascular coagulation [defibrination syndrome]
0.000 0.384 0.616
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.387 0.613
E63 Other nutritional deficiencies
0.000 0.387 0.613
E50 Vitamin A deficiency
0.000 0.387 0.613
E60 Dietary zinc deficiency
0.000 0.387 0.613
E59 Dietary selenium deficiency
0.000 0.387 0.613
E52 Niacin deficiency [pellagra]
0.000 0.387 0.613
D72.9 Disorder of white blood cells, unspecified
0.000 0.390 0.610
D72.0 Genetic anomalies of leukocytes
0.000 0.390 0.610
D50 Iron deficiency anaemia
0.000 0.407 0.593
D84 Other immunodeficiencies
0.000 0.408 0.592
E14.8 With unspecified complications
0.000 0.409 0.591
E54 Ascorbic acid deficiency
0.000 0.411 0.589
D72.1 Eosinophilia
0.000 0.414 0.586
E55.0 Rickets, active
0.000 0.421 0.579
E14.1 With ketoacidosis
0.000 0.424 0.576
D75.2 Essential thrombocytosis
0.000 0.427 0.573
D53.8 Other specified nutritional anaemias
0.000 0.427 0.573
D53.2 Scorbutic anaemia
0.000 0.427 0.573
D53.1 Other megaloblastic anaemias, not elsewhere classified
0.000 0.427 0.573
D53.0 Protein deficiency anaemia
0.000 0.427 0.573
D80.8 Other immunodeficiencies with predominantly antibody defects
0.000 0.428 0.572
D80.7 Transient hypogammaglobulinaemia of infancy
0.000 0.428 0.572
D80.6 Antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinaemia
0.000 0.428 0.572
D80.5 Immunodeficiency with increased immunoglobulin M [IgM]
0.000 0.428 0.572
D80.0 Hereditary hypogammaglobulinaemia
0.000 0.428 0.572
D89 Other disorders involving the immune mechanism, not elsewhere classified
0.000 0.430 0.570
E58 Dietary calcium deficiency
0.000 0.435 0.564
D55 Anaemia due to enzyme disorders
0.000 0.438 0.562
E06.9 Thyroiditis, unspecified
0.009 0.439 0.552
E56 Other vitamin deficiencies
0.000 0.442 0.558
D67 Hereditary factor IX deficiency
0.000 0.443 0.557
D83.8 Other common variable immunodeficiencies
0.000 0.447 0.553
D83.2 Common variable immunodeficiency with autoantibodies to B- or T-cells
0.000 0.447 0.553
D83.1 Common variable immunodeficiency with predominant immunoregulatory T-cell disorders
0.000 0.447 0.553
D83.0 Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function
0.000 0.447 0.553
E05.9 Thyrotoxicosis, unspecified
0.000 0.449 0.550
E14.6 With other specified complications
0.000 0.451 0.548
E03.5 Myxoedema coma
0.295 0.452 0.253
E03.4 Atrophy of thyroid (acquired)
0.295 0.452 0.253
E03.3 Postinfectious hypothyroidism
0.295 0.452 0.253
E65-E68 Obesity and other hyperalimentation
0.000 0.453 0.547
E07 Other disorders of thyroid
0.052 0.455 0.493
E83.1 Disorders of iron metabolism
0.000 0.460 0.540
E03.0 Congenital hypothyroidism with diffuse goitre
0.293 0.461 0.247
E13.9 Without complications
0.000 0.462 0.538
D69.6 Thrombocytopenia, unspecified
0.000 0.463 0.537
D75.8 Other specified diseases of blood and blood-forming organs
0.000 0.463 0.537
D57 Sickle-cell disorders
0.000 0.465 0.535
D80.9 Immunodeficiency with predominantly antibody defects, unspecified
0.000 0.466 0.534
E14.7 With multiple complications
0.000 0.466 0.534
E14.2 Withrenal complications
0.000 0.466 0.534
E14.0 With coma
0.000 0.466 0.534
E03.1 Congenital hypothyroidism without goitre
0.260 0.469 0.271
D59.8 Other acquired haemolytic anaemias
0.000 0.472 0.528
D59.6 Haemoglobinuria due to haemolysis from other external causes
0.000 0.472 0.528
D59.5 Paroxysmal nocturnal haemoglobinuria [Marchiafava-Micheli]
0.000 0.472 0.528
D59.4 Other nonautoimmune haemolytic anaemias
0.000 0.472 0.528
D59.3 Haemolytic-uraemic syndrome
0.000 0.472 0.528
D59.2 Drug-induced nonautoimmune haemolytic anaemia
0.000 0.472 0.528
D59.0 Drug-induced autoimmune haemolytic anaemia
0.000 0.472 0.528
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.005 0.472 0.523
D69.2 Other nonthrombocytopenic purpura
0.000 0.477 0.523
L40.8 Other psoriasis
0.000 0.478 0.522
E70-E90 Metabolic disorders
0.000 0.479 0.521
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.306 0.482 0.212
D69.5 Secondary thrombocytopenia
0.000 0.484 0.516
E14.5 With peripheral circulatory complications
0.000 0.484 0.516
E12.9 Without complications
0.000 0.486 0.514
E12.8 With unspecified complications
0.000 0.486 0.514
E12.7 With multiple complications
0.000 0.486 0.514
E12.6 With other specified complications
0.000 0.486 0.514
E12.5 With peripheral circulatory complications
0.000 0.486 0.514
E12.4 With neurological complications
0.000 0.486 0.514
E12.3 With ophthalmic complications
0.000 0.486 0.514
E12.2 With renal complications
0.000 0.486 0.514
E12.1 With ketoacidosis
0.000 0.486 0.514
E12.0 With coma
0.000 0.486 0.514
E83 Disorders of mineral metabolism
0.000 0.490 0.510
E13.8 With unspecified complications
0.000 0.490 0.509
E13.7 With multiple complications
0.000 0.490 0.509
E13.6 With other specified complications
0.000 0.490 0.509
E13.5 With peripheral circulatory complications
0.000 0.490 0.509
E13.4 With neurological complications
0.000 0.490 0.509
E13.2 With renal complications
0.000 0.490 0.509
E13.1 With ketoacidosis
0.000 0.490 0.509
E13.0 With coma
0.000 0.490 0.509
E04 Other non-toxic goitre
0.003 0.495 0.502
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.021 0.496 0.483
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.021 0.496 0.483
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.021 0.496 0.483
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.021 0.496 0.483
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.021 0.496 0.483
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.021 0.496 0.483
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.021 0.496 0.483
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.021 0.496 0.483
E20-E35 Disorders of other endocrine glands
0.000 0.497 0.503
D81.9 Combined immunodeficiency, unspecified
0.000 0.498 0.502
D81.8 Other combined immunodeficiencies
0.000 0.498 0.502
D81.7 Major histocompatibility complex class II deficiency
0.000 0.498 0.502
D81.6 Major histocompatibility complex class I deficiency
0.000 0.498 0.502
D81.5 Purine nucleoside phosphorylase [PNP] deficiency
0.000 0.498 0.502
D81.4 Nezelof's syndrome
0.000 0.498 0.502
D81.3 Adenosine deaminase [ADA] deficiency
0.000 0.498 0.502
D81.2 Severe combined immunodeficiency [SCID] with low or normal B-cell numbers
0.000 0.498 0.502
D81.1 Severe combined immunodeficiency [SCID] with low T- and B-cell numbers
0.000 0.498 0.502
D81.0 Severe combined immunodeficiency [SCID] with reticular dysgenesis
0.000 0.498 0.502
D75.1 Secondary polycythaemia
0.000 0.502 0.498
E27.1 Primary adrenocortical insufficiency
0.000 0.503 0.497
D74.9 Methaemoglobinaemia, unspecified
0.000 0.504 0.496
D74.8 Other methaemoglobinaemias
0.000 0.504 0.496
D74.0 Congenital methaemoglobinaemia
0.000 0.504 0.496
E27 Other disorders of adrenal gland
0.000 0.505 0.495
E53.9 Vitamin B deficiency, unspecified
0.000 0.506 0.494
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.507 0.493
E45 Retarded development following protein-energy malnutrition
0.000 0.507 0.493
E43 Unspecified severe protein-energy malnutrition
0.000 0.507 0.493
E42 Marasmic kwashiorkor
0.000 0.507 0.493
E41 Nutritional marasmus
0.000 0.507 0.493
E40 Kwashiorkor
0.000 0.507 0.493
E14.4 With neurological complications
0.000 0.508 0.492
E51.2 Wernicke's encephalopathy
0.000 0.509 0.491
D58 Other hereditary haemolytic anaemias
0.000 0.511 0.489
E03.8 Other specified hypothyroidism
0.263 0.512 0.224
D50.9 Iron deficiency anaemia, unspecified
0.000 0.514 0.486
D80.4 Selective deficiency of immunoglobulin M [IgM]
0.000 0.515 0.485
D82.9 Immunodeficiency associated with major defect, unspecified
0.000 0.519 0.481
D82.8 Immunodeficiency associated with other specified major defects
0.000 0.519 0.481
D82.4 Hyperimmunoglobulin E [IgE] syndrome
0.000 0.519 0.481
D82.3 Immunodeficiency following hereditary defective response to Epstein-Barr virus
0.000 0.519 0.481
D82.2 Immunodeficiency with short-limbed stature
0.000 0.519 0.481
D82.0 Wiskott-Aldrich syndrome
0.000 0.519 0.481
E06.4 Drug-induced thyroiditis
0.015 0.523 0.462
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.015 0.523 0.462
E06.0 Acute thyroiditis
0.015 0.523 0.462
E88 Other metabolic disorders
0.000 0.527 0.473
E13.3 With ophthalmic complications
0.000 0.530 0.470
D69.3 Idiopathic thrombocytopenic purpura
0.000 0.532 0.468
E46 Unspecified protein-energy malnutrition
0.000 0.534 0.466
D84.1 Defects in the complement system
0.000 0.537 0.463
D76.2 Haemophagocytic syndrome, infection-associated
0.000 0.538 0.462
D76.1 Haemophagocytic lymphohistiocytosis
0.000 0.538 0.462
D76.0 Langerhans' cell histiocytosis, not elsewhere classified
0.000 0.538 0.462
D69.9 Haemorrhagic condition, unspecified
0.000 0.538 0.462
E51.9 Thiamine deficiency, unspecified
0.000 0.539 0.461
E51.8 Other manifestations of thiamine deficiency
0.000 0.539 0.461
E51.1 Beriberi
0.000 0.539 0.461
E53.1 Pyridoxine deficiency
0.000 0.539 0.461
E53.0 Riboflavin deficiency
0.000 0.539 0.461
E85 Amyloidosis
0.000 0.540 0.460
D52 Folate deficiency anaemia
0.000 0.541 0.458
E53.8 Deficiency of other specified B group vitamins
0.000 0.544 0.456
D82.1 Di George's syndrome
0.000 0.549 0.451
D69.8 Other specified haemorrhagic conditions
0.000 0.550 0.449
D50.8 Other iron deficiency anaemias
0.000 0.551 0.449
E06.3 Autoimmune thyroiditis
0.008 0.559 0.433
E50.9 Vitamin A deficiency, unspecified
0.000 0.560 0.440
E50.8 Other manifestations of vitamin A deficiency
0.000 0.560 0.440
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.560 0.440
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.560 0.440
E50.5 Vitamin A deficiency with night blindness
0.000 0.560 0.440
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.560 0.440
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.560 0.440
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.560 0.440
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.560 0.440
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.560 0.440
E63.9 Nutritional deficiency, unspecified
0.000 0.560 0.440
E63.8 Other specified nutritional deficiencies
0.000 0.560 0.440
E63.1 Imbalance of constituents of food intake
0.000 0.560 0.440
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.560 0.440
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.560 0.440
E64.8 Sequelae of other nutritional deficiencies
0.000 0.560 0.440
E64.3 Sequelae of rickets
0.000 0.560 0.440
E64.2 Sequelae of vitamin C deficiency
0.000 0.560 0.440
E64.1 Sequelae of vitamin A deficiency
0.000 0.560 0.440
E64.0 Sequelae of protein-energy malnutrition
0.000 0.560 0.440
E61 Deficiency of other nutrient elements
0.000 0.566 0.434
D89.8 Other specified disorders involving the immune mechanism, not elsewhere classified
0.000 0.567 0.433
E88.0 Disorders of plasma-protein metabolism, not elsewhere classified
0.000 0.568 0.432
D69.1 Qualitative platelet defects
0.000 0.575 0.425
D50.1 Sideropenic dysphagia
0.000 0.575 0.425
D84.8 Other specified immunodeficiencies
0.000 0.575 0.424
D84.0 Lymphocyte function antigen-1 [LFA-1] defect
0.000 0.575 0.424
D89.9 Disorder involving the immune mechanism, unspecified
0.000 0.577 0.423
E07.8 Other specified disorders of thyroid
0.026 0.577 0.397
E34 Other endocrine disorders
0.000 0.578 0.422
E04.0 Non-toxic diffuse goitre
0.001 0.580 0.419
K90 Intestinal malabsorption
0.000 0.581 0.419
D76.3 Other histiocytosis syndromes
0.000 0.584 0.416
E06.1 Subacute thyroiditis
0.017 0.586 0.397
E85.4 Organ-limited amyloidosis
0.000 0.587 0.413
E11.2 With renal complications
0.000 0.587 0.412
D89.3 Immune reconstitution syndrome
0.000 0.591 0.409
E11.0 With coma
0.000 0.594 0.405
D55.9 Anaemia due to enzyme disorder, unspecified
0.000 0.597 0.403
D55.8 Other anaemias due to enzyme disorders
0.000 0.597 0.403
D55.3 Anaemia due to disorders of nucleotide metabolism
0.000 0.597 0.403
D55.2 Anaemia due to disorders of glycolytic enzymes
0.000 0.597 0.403
D55.1 Anaemia due to other disorders of glutathione metabolism
0.000 0.597 0.403
D55.0 Anaemia due to glucose-6-phosphate dehydrogenase [G6PD] deficiency
0.000 0.597 0.403
E56.9 Vitamin deficiency, unspecified
0.000 0.600 0.400
E56.8 Deficiency of other vitamins
0.000 0.600 0.400
E56.0 Deficiency of vitamin E
0.000 0.600 0.400
D69.4 Other primary thrombocytopenia
0.000 0.603 0.397
E04.9 Non-toxic goitre, unspecified
0.000 0.604 0.396
E20 Hypoparathyroidism
0.000 0.605 0.395
E06.5 Other chronic thyroiditis
0.017 0.606 0.377
D89.1 Cryoglobulinaemia
0.000 0.606 0.393
E79 Disorders of purine and pyrimidine metabolism
0.000 0.607 0.393
E67 Other hyperalimentation
0.000 0.607 0.392
E68 Sequelae of hyperalimentation
0.000 0.607 0.392
E07.1 Dyshormogenetic goitre
0.037 0.609 0.353
E07.0 Hypersecretion of calcitonin
0.037 0.609 0.353
E70 Disorders of aromatic amino-acid metabolism
0.000 0.612 0.388
D57.8 Other sickle-cell disorders
0.000 0.616 0.384
D57.3 Sickle-cell trait
0.000 0.616 0.384
D57.2 Double heterozygous sickling disorders
0.000 0.616 0.384
D57.0 Sickle-cell anaemia with crisis
0.000 0.616 0.384
E88.1 Lipodystrophy, not elsewhere classified
0.000 0.619 0.381
E27.3 Drug-induced adrenocortical insufficiency
0.000 0.620 0.380
E34.9 Endocrine disorder, unspecified
0.000 0.626 0.374
E77 Disorders of glycoprotein metabolism
0.000 0.626 0.374
E76 Disorders of glycosaminoglycan metabolism
0.000 0.626 0.374
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.000 0.626 0.374
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.000 0.626 0.374
E25 Adrenogenital disorders
0.000 0.627 0.373
E88.9 Metabolic disorder, unspecified
0.000 0.629 0.371
E66 Obesity
0.000 0.632 0.368
E83.8 Other disorders of mineral metabolism
0.000 0.634 0.366
E83.2 Disorders of zinc metabolism
0.000 0.634 0.366
E83.0 Disorders of copper metabolism
0.000 0.634 0.366
D58.2 Other haemoglobinopathies
0.000 0.638 0.362
E04.8 Other specified non-toxic goitre
0.002 0.638 0.360
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.639 0.361
E32 Diseases of thymus
0.000 0.639 0.361
E31 Polyglandular dysfunction
0.000 0.639 0.361
E30 Disorders of puberty, not elsewhere classified
0.000 0.639 0.361
D57.1 Sickle-cell anaemia without crisis
0.000 0.642 0.357
D56 Thalassaemia
0.001 0.645 0.354
E27.5 Adrenomedullary hyperfunction
0.000 0.645 0.355
E27.0 Other adrenocortical overactivity
0.000 0.645 0.355
E44.1 Mild protein-energy malnutrition
0.000 0.646 0.354
E44.0 Moderate protein-energy malnutrition
0.000 0.646 0.354
E27.2 Addisonian crisis
0.000 0.649 0.351
D58.8 Other specified hereditary haemolytic anaemias
0.000 0.649 0.351
D58.1 Hereditary elliptocytosis
0.000 0.649 0.351
E83.9 Disorder of mineral metabolism, unspecified
0.000 0.649 0.351
E84 Cystic fibrosis
0.000 0.650 0.350
E85.3 Secondary systemic amyloidosis
0.000 0.651 0.349
E56.1 Deficiency of vitamin K
0.000 0.655 0.345
E72 Other disorders of amino-acid metabolism
0.000 0.657 0.343
E34.0 Carcinoid syndrome
0.000 0.662 0.338
E88.3 Tumour lysis syndrome
0.000 0.662 0.338
D89.0 Polyclonal hypergammaglobulinaemia
0.000 0.663 0.336
K90.9 Intestinal malabsorption, unspecified
0.000 0.668 0.332
D89.2 Hypergammaglobulinaemia, unspecified
0.000 0.668 0.332
E85.8 Other amyloidosis
0.000 0.670 0.330
E85.2 Heredofamilial amyloidosis, unspecified
0.000 0.670 0.330
E85.1 Neuropathic heredofamilial amyloidosis
0.000 0.670 0.330
E85.0 Nonneuropathic heredofamilial amyloidosis
0.000 0.670 0.330
D52.8 Other folate deficiency anaemias
0.000 0.671 0.329
D52.1 Drug-induced folate deficiency anaemia
0.000 0.671 0.329
D52.0 Dietary folate deficiency anaemia
0.000 0.671 0.329
E74 Other disorders of carbohydrate metabolism
0.000 0.673 0.327
E27.8 Other specified disorders of adrenal gland
0.000 0.675 0.325
E88.8 Other specified metabolic disorders
0.000 0.678 0.321
D58.9 Hereditary haemolytic anaemia, unspecified
0.000 0.679 0.321
E85.9 Amyloidosis, unspecified
0.000 0.682 0.318
E20.9 Hypoparathyroidism, unspecified
0.000 0.682 0.318
E66.2 Extreme obesity with alveolar hypoventilation
0.000 0.686 0.314
E61.9 Deficiency of nutrient element, unspecified
0.000 0.689 0.311
E61.8 Deficiency of other specified nutrient elements
0.000 0.689 0.311
E61.7 Deficiency of multiple nutrient elements
0.000 0.689 0.311
E61.6 Vanadium deficiency
0.000 0.689 0.311
E61.5 Molybdenum deficiency
0.000 0.689 0.311
E61.4 Chromium deficiency
0.000 0.689 0.311
E61.3 Manganese deficiency
0.000 0.689 0.311
E61.0 Copper deficiency
0.000 0.689 0.311
D60-D64 Aplastic and other anaemias
0.000 0.692 0.307
E66.0 Obesity due to excess calories
0.000 0.694 0.306
E34.5 Androgen resistance syndrome
0.000 0.697 0.303
E34.4 Constitutional tall stature
0.000 0.697 0.303
E34.2 Ectopic hormone secretion, not elsewhere classified
0.000 0.697 0.303
E34.1 Other hypersecretion of intestinal hormones
0.000 0.697 0.303
E24 Cushing's syndrome
0.000 0.697 0.302
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
0.000 0.699 0.301
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.000 0.699 0.301
K90.3 Pancreatic steatorrhoea
0.000 0.699 0.300
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.699 0.300
K90.1 Tropical sprue
0.000 0.699 0.300
D58.0 Hereditary spherocytosis
0.000 0.700 0.300
E22 Hyperfunction of pituitary gland
0.000 0.701 0.299
E29 Testicular dysfunction
0.000 0.702 0.297
E86 Volume depletion
0.000 0.703 0.297
E27.4 Other and unspecified adrenocortical insufficiency
0.000 0.707 0.293
E70.3 Albinism
0.000 0.707 0.293
E73 Lactose intolerance
0.000 0.707 0.292
E34.3 Short stature, not elsewhere classified
0.000 0.709 0.291
E88.2 Lipomatosis, not elsewhere classified
0.000 0.711 0.289
E20.8 Other hypoparathyroidism
0.000 0.716 0.283
E20.1 Pseudohypoparathyroidism
0.000 0.716 0.283
E20.0 Idiopathic hypoparathyroidism
0.000 0.716 0.283
E79.9 Disorder of purine and pyrimidine metabolism, unspecified
0.000 0.718 0.282
E79.8 Other disorders of purine and pyrimidine metabolism
0.000 0.718 0.282
E79.1 Lesch-Nyhan syndrome
0.000 0.718 0.282
E67.8 Other specified hyperalimentation
0.000 0.718 0.281
E67.3 Hypervitaminosis D
0.000 0.718 0.281
E67.2 Megavitamin-B6 syndrome
0.000 0.718 0.281
E67.1 Hypercarotenaemia
0.000 0.718 0.281
E67.0 Hypervitaminosis A
0.000 0.718 0.281
K90.8 Other intestinal malabsorption
0.000 0.718 0.281
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.000 0.720 0.279
E70.9 Disorder of aromatic amino-acid metabolism, unspecified
0.000 0.721 0.278
E70.8 Other disorders of aromatic amino-acid metabolism
0.000 0.721 0.278
E70.2 Disorders of tyrosine metabolism
0.000 0.721 0.278
E70.1 Other hyperphenylalaninaemias
0.000 0.721 0.278
E70.0 Classical phenylketonuria
0.000 0.721 0.278
S64.4 Injury of digital nerve of other finger
0.276 0.724 0.000
E61.2 Magnesium deficiency
0.000 0.726 0.274
E65 Localised adiposity
0.000 0.731 0.268
E71.3 Disorders of fatty-acid metabolism
0.000 0.732 0.268
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified
0.000 0.732 0.268
E71.1 Other disorders of branched-chain amino-acid metabolism
0.000 0.732 0.268
E71.0 Maple-syrup-urine disease
0.000 0.732 0.268
E76.9 Disorder of glucosaminoglycan metabolism, unspecified
0.000 0.732 0.268
E76.8 Other disorders of glucosaminoglycan metabolism
0.000 0.732 0.268
E76.3 Mucopolysaccharidosis, unspecified
0.000 0.732 0.268
E76.2 Other mucopolysaccharidoses
0.000 0.732 0.268
E76.1 Mucopolysaccharidosis, type II
0.000 0.732 0.268
E76.0 Mucopolysaccharidosis, type I
0.000 0.732 0.268
E77.9 Disorder of glycoprotein metabolism, unspecified
0.000 0.732 0.268
E77.8 Other disorders of glycoprotein metabolism
0.000 0.732 0.268
E77.1 Defects in glycoprotein degradation
0.000 0.732 0.268
E77.0 Defects in posttranslational modification of lysosomal enzymes
0.000 0.732 0.268
E25.9 Adrenogenital disorder, unspecified
0.000 0.732 0.267
E25.8 Other adrenogenital disorders
0.000 0.732 0.267
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.000 0.735 0.265
E66.1 Drug-induced obesity
0.000 0.736 0.264
E14.9 Without complications
0.000 0.740 0.260
E30.9 Disorder of puberty, unspecified
0.000 0.741 0.259
E30.8 Other disorders of puberty
0.000 0.741 0.259
E30.1 Precocious puberty
0.000 0.741 0.259
E30.0 Delayed puberty
0.000 0.741 0.259
E31.9 Polyglandular dysfunction, unspecified
0.000 0.741 0.259
E31.8 Other polyglandular dysfunction
0.000 0.741 0.259
E31.1 Polyglandular hyperfunction
0.000 0.741 0.259
E31.0 Autoimmune polyglandular failure
0.000 0.741 0.259
E32.9 Disease of thymus, unspecified
0.000 0.741 0.259
E32.8 Other diseases of thymus
0.000 0.741 0.259
E32.1 Abscess of thymus
0.000 0.741 0.259
E32.0 Persistent hyperplasia of thymus
0.000 0.741 0.259
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.741 0.259
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.741 0.259
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.741 0.259
D73 Diseases of spleen
0.000 0.743 0.256
D56.9 Thalassaemia, unspecified
0.001 0.745 0.254
D56.8 Other thalassaemias
0.001 0.745 0.254
D56.4 Hereditary persistence of foetal haemoglobin [HPFH]
0.001 0.745 0.254
D56.2 Delta-beta thalassaemia
0.001 0.745 0.254
D56.0 Alpha thalassaemia
0.001 0.745 0.254
E26 Hyperaldosteronism
0.000 0.748 0.252
E84.8 Cystic fibrosis with other manifestations
0.000 0.749 0.251
E84.1 Cystic fibrosis with intestinal manifestations
0.000 0.749 0.251
E84.0 Cystic fibrosis with pulmonary manifestations
0.000 0.749 0.251
E72.9 Disorder of amino-acid metabolism, unspecified
0.000 0.754 0.246
E72.8 Other specified disorders of amino-acid metabolism
0.000 0.754 0.246
E72.5 Disorders of glycine metabolism
0.000 0.754 0.246
E72.4 Disorders of ornithine metabolism
0.000 0.754 0.246
E72.3 Disorders of lysine and hydroxylysine metabolism
0.000 0.754 0.246
E72.2 Disorders of urea cycle metabolism
0.000 0.754 0.246
E72.1 Disorders of sulphur-bearing amino-acid metabolism
0.000 0.754 0.246
E66.8 Other obesity
0.000 0.754 0.246
E22.1 Hyperprolactinaemia
0.000 0.760 0.240
E34.8 Other specified endocrine disorders
0.000 0.762 0.238
E24.0 Pituitary-dependent Cushing's disease
0.000 0.765 0.235
E74.9 Disorder of carbohydrate metabolism, unspecified
0.000 0.765 0.235
E74.8 Other specified disorders of carbohydrate metabolism
0.000 0.765 0.235
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
0.000 0.765 0.235
E74.2 Disorders of galactose metabolism
0.000 0.765 0.235
E74.1 Disorders of fructose metabolism
0.000 0.765 0.235
E74.0 Glycogen storage disease
0.000 0.765 0.235
D84.9 Immunodeficiency, unspecified
0.001 0.766 0.233
E04.1 Non-toxic single thyroid nodule
0.001 0.768 0.231
E27.9 Disorder of adrenal gland, unspecified
0.000 0.772 0.228
E84.9 Cystic fibrosis, unspecified
0.000 0.772 0.227
D61 Other aplastic anaemias
0.000 0.780 0.220
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.000 0.783 0.217
E24.3 Ectopic ACTH syndrome
0.000 0.783 0.217
E24.1 Nelson's syndrome
0.000 0.783 0.217
E75.6 Lipid storage disorder, unspecified
0.000 0.784 0.216

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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