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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs2517527
log Bayes Factor = 84.9212
Chromosome 6   position 31,021,547  (GRCh37) Explore rs2517527 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E03.9 Hypothyroidism, unspecified
0.000 0.000 1.000
E05.9 Thyrotoxicosis, unspecified
0.000 0.000 1.000
K90.0 Coeliac disease
0.000 0.000 1.000
L40.9 Psoriasis, unspecified
0.000 0.000 1.000
E03 Other hypothyroidism
0.000 0.000 1.000
E00-E07 Disorders of thyroid gland
0.000 0.000 1.000
L40 Psoriasis
0.000 0.000 1.000
L40.5 Arthropathic psoriasis
0.000 0.000 1.000
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.000 1.000
C83.3 Large cell (diffuse)
0.000 0.016 0.984
E83.1 Disorders of iron metabolism
0.981 0.019 0.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.026 0.974
E10-E14 Diabetes mellitus
0.000 0.030 0.970
E10 Insulin-dependent diabetes mellitus
0.000 0.034 0.966
E10.3 With ophthalmic complications
0.000 0.044 0.956
C83 Diffuse non-Hodgkin's lymphoma
0.000 0.062 0.938
E07 Other disorders of thyroid
0.000 0.074 0.926
L40.0 Psoriasis vulgaris
0.000 0.074 0.926
C81-C96 Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissue
0.000 0.075 0.925
E10.9 Without complications
0.000 0.076 0.924
C85 Other and unspecified types of non-Hodgkin's lymphoma
0.000 0.078 0.922
C85.9 Non-Hodgkin's lymphoma, unspecified type
0.000 0.094 0.906
C85.1 B-cell lymphoma, unspecified
0.000 0.103 0.897
C82 Follicular [nodular] non-Hodgkin's lymphoma
0.000 0.109 0.891
E07.9 Disorder of thyroid, unspecified
0.000 0.115 0.885
C81 Hodgkin's disease
0.000 0.132 0.868
E70-E90 Metabolic disorders
0.001 0.133 0.867
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.000 0.135 0.865
E03.8 Other specified hypothyroidism
0.000 0.138 0.862
E78.0 Pure hypercholesterolaemia
0.000 0.144 0.856
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.000 0.151 0.849
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.158 0.842
C61 Malignant neoplasm of prostate
0.841 0.159 0.000
E89.0 Postprocedural hypothyroidism
0.000 0.169 0.831
I83.9 Varicose veins of lower extremities without ulcer or inflammation
0.828 0.172 0.000
L40.1 Generalised pustular psoriasis
0.000 0.174 0.826
E40-E46 Malnutrition
0.000 0.174 0.825
C82.9 Follicular non-Hodgkin's lymphoma, unspecified
0.000 0.178 0.822
C83.7 Burkitt's tumour
0.000 0.182 0.818
E10.2 With renal complications
0.000 0.184 0.816
E78.8 Other disorders of lipoprotein metabolism
0.000 0.188 0.812
E13 Other specified diabetes mellitus
0.000 0.191 0.809
E78.5 Hyperlipidaemia, unspecified
0.000 0.211 0.789
C81.9 Hodgkin's disease, unspecified
0.000 0.222 0.778
L40.8 Other psoriasis
0.000 0.230 0.770
C82.2 Large cell, follicular
0.000 0.238 0.762
C82.7 Other types of follicular non-Hodgkin's lymphoma
0.000 0.248 0.752
C84 Peripheral and cutaneous T-cell lymphomas
0.000 0.248 0.752
E14 Unspecified diabetes mellitus
0.000 0.258 0.742
C82.3 Follicular lymphoma grade IIIa
0.000 0.258 0.742
L40.4 Guttate psoriasis
0.000 0.261 0.739
E20-E35 Disorders of other endocrine glands
0.000 0.278 0.722
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.280 0.719
E46 Unspecified protein-energy malnutrition
0.000 0.281 0.719
E03.5 Myxoedema coma
0.000 0.283 0.717
E03.4 Atrophy of thyroid (acquired)
0.000 0.283 0.717
E03.3 Postinfectious hypothyroidism
0.000 0.283 0.717
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.283 0.717
E00 Congenital iodine-deficiency syndrome
0.000 0.283 0.717
L40.2 Acrodermatitis continua
0.000 0.283 0.717
E05.5 Thyroid crisis or storm
0.000 0.283 0.717
E05.4 Thyrotoxicosis factitia
0.000 0.283 0.717
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.283 0.717
C83.9 Diffuse non-Hodgkin's lymphoma, unspecified
0.000 0.284 0.716
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.285 0.715
E89.4 Postprocedural ovarian failure
0.000 0.297 0.703
E10.8 With unspecified complications
0.000 0.297 0.703
E12 Malnutrition-related diabetes mellitus
0.000 0.304 0.696
E24 Cushing's syndrome
0.000 0.307 0.693
C81.2 Mixed cellularity
0.000 0.316 0.684
C81.0 Lymphocytic predominance
0.000 0.319 0.681
E74 Other disorders of carbohydrate metabolism
0.000 0.319 0.680
C83.6 Undifferentiated (diffuse)
0.000 0.327 0.673
C83.4 Immunoblastic (diffuse)
0.000 0.327 0.673
C83.2 Mixed small and large cell (diffuse)
0.000 0.327 0.673
C81.1 Nodular sclerosis
0.000 0.330 0.670
E89.2 Postprocedural hypoparathyroidism
0.000 0.330 0.670
E13.9 Without complications
0.000 0.334 0.666
E07.1 Dyshormogenetic goitre
0.000 0.336 0.664
E07.0 Hypersecretion of calcitonin
0.000 0.336 0.664
E10.7 With multiple complications
0.000 0.336 0.663
C96 Other and unspecified malignant neoplasms of lymphoid, haematopoietic and related tissue
0.000 0.337 0.663
E06 Thyroiditis
0.000 0.337 0.663
C85.0 Lymphosarcoma
0.000 0.339 0.661
E10.4 With neurological complications
0.000 0.341 0.659
E11 Non-insulin-dependent diabetes mellitus
0.000 0.347 0.653
E73 Lactose intolerance
0.000 0.347 0.652
C86 Other specified types of T/NK-cell lymphoma
0.000 0.353 0.647
C84.5 Other and unspecified T-cell lymphomas
0.000 0.355 0.645
E78.6 Lipoprotein deficiency
0.000 0.357 0.643
E10.0 With coma
0.000 0.360 0.640
E14.3 With ophthalmic complications
0.000 0.361 0.639
C82.6 Cutaneous follicle centre lymphoma
0.000 0.361 0.639
C82.5 Diffuse follicle centre lymphoma
0.000 0.361 0.639
C85.2 Mediastinal (thymic) large B-cell lymphoma
0.000 0.363 0.637
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.363 0.637
E72 Other disorders of amino-acid metabolism
0.001 0.366 0.634
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.366 0.633
E78.2 Mixed hyperlipidaemia
0.000 0.368 0.632
K90 Intestinal malabsorption
0.000 0.369 0.631
E23 Hypofunction and other disorders of pituitary gland
0.000 0.370 0.630
C81.7 Other Hodgkin's disease
0.000 0.373 0.627
E11.0 With coma
0.000 0.375 0.625
C94 Other leukaemias of specified cell type
0.000 0.376 0.624
E13.3 With ophthalmic complications
0.000 0.376 0.624
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.001 0.377 0.622
C81.4 Lymphocyte-rich classical Hodgkin lymphoma
0.000 0.378 0.622
C81.3 Lymphocytic depletion
0.000 0.378 0.622
E77 Disorders of glycoprotein metabolism
0.001 0.378 0.621
E76 Disorders of glycosaminoglycan metabolism
0.001 0.378 0.621
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.001 0.378 0.621
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.001 0.378 0.621
E78.4 Other hyperlipidaemia
0.000 0.380 0.620
E10.6 With other specified complications
0.000 0.381 0.619
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.385 0.615
E05.8 Other thyrotoxicosis
0.000 0.388 0.612
C93 Monocytic leukaemia
0.000 0.389 0.611
E24.9 Cushing's syndrome, unspecified
0.000 0.390 0.610
E14.6 With other specified complications
0.000 0.391 0.609
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.000 0.391 0.609
E89.9 Postprocedural endocrine and metabolic disorder, unspecified
0.000 0.391 0.608
E89.8 Other postprocedural endocrine and metabolic disorders
0.000 0.391 0.608
E89.5 Postprocedural testicular hypofunction
0.000 0.391 0.608
E89.3 Postprocedural hypopituitarism
0.000 0.392 0.608
C82.4 Follicular lymphoma grade IIIb
0.000 0.396 0.604
C82.0 Small cleaved cell, follicular
0.000 0.400 0.600
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.402 0.598
E14.5 With peripheral circulatory complications
0.000 0.402 0.598
E24.2 Drug-induced Cushing's syndrome
0.000 0.403 0.597
C83.5 Lymphoblastic (diffuse)
0.000 0.404 0.596
E07.8 Other specified disorders of thyroid
0.000 0.406 0.594
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.408 0.592
E45 Retarded development following protein-energy malnutrition
0.000 0.408 0.592
E43 Unspecified severe protein-energy malnutrition
0.000 0.408 0.592
E42 Marasmic kwashiorkor
0.000 0.408 0.592
E41 Nutritional marasmus
0.000 0.408 0.592
E40 Kwashiorkor
0.000 0.408 0.592
E24.0 Pituitary-dependent Cushing's disease
0.000 0.409 0.591
E11.1 With ketoacidosis
0.000 0.410 0.590
C84.8 Cutaneous T-cell lymphoma, unspecified
0.000 0.411 0.589
E03.1 Congenital hypothyroidism without goitre
0.000 0.412 0.588
E70 Disorders of aromatic amino-acid metabolism
0.001 0.412 0.587
E11.9 Without complications
0.000 0.415 0.585
E28 Ovarian dysfunction
0.000 0.417 0.583
E13.8 With unspecified complications
0.000 0.420 0.580
E13.7 With multiple complications
0.000 0.420 0.580
E13.6 With other specified complications
0.000 0.420 0.580
E13.5 With peripheral circulatory complications
0.000 0.420 0.580
E13.4 With neurological complications
0.000 0.420 0.580
E13.2 With renal complications
0.000 0.420 0.580
E13.1 With ketoacidosis
0.000 0.420 0.580
E13.0 With coma
0.000 0.420 0.580
L40.3 Pustulosis palmaris et plantaris
0.000 0.424 0.575
C83.8 Other types of diffuse non-Hodgkin's lymphoma
0.000 0.432 0.568
E78.3 Hyperchylomicronaemia
0.000 0.436 0.564
C83.1 Small cleaved cell (diffuse)
0.000 0.437 0.562
E21.3 Hyperparathyroidism, unspecified
0.000 0.439 0.561
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.000 0.445 0.555
E25 Adrenogenital disorders
0.000 0.446 0.554
C85.7 Other specified types of non-Hodgkin's lymphoma
0.000 0.446 0.553
E78.1 Pure hyperglyceridaemia
0.000 0.447 0.553
E10.1 With ketoacidosis
0.000 0.447 0.553
C95 Leukaemia of unspecified cell type
0.000 0.448 0.552
E74.3 Other disorders of intestinal carbohydrate absorption
0.000 0.448 0.552
E23.7 Disorder of pituitary gland, unspecified
0.000 0.449 0.551
C84.0 Mycosis fungoides
0.000 0.454 0.546
E89.1 Postprocedural hypoinsulinaemia
0.000 0.457 0.542
E14.8 With unspecified complications
0.000 0.458 0.541
C84.9 Mature T/NK-cell lymphoma, unspecified
0.000 0.461 0.539
C84.7 Anaplastic large cell lymphoma, ALK-negative
0.000 0.461 0.539
C84.6 Anaplastic large cell lymphoma, ALK-positive
0.000 0.461 0.539
C84.3 Lymphoepithelioid lymphoma
0.000 0.461 0.539
C84.2 T-zone lymphoma
0.000 0.461 0.539
C84.1 Sezary's diease
0.000 0.461 0.539
E23.2 Diabetes insipidus
0.000 0.461 0.539
E89.6 Postprocedural adrenocortical(-medullary) hypofunction
0.000 0.464 0.536
E10.5 With peripheral circulatory complications
0.000 0.466 0.534
C88 Malignant immunoproliferative diseases
0.000 0.467 0.533
E14.7 With multiple complications
0.000 0.468 0.532
E14.0 With coma
0.000 0.468 0.532
E88 Other metabolic disorders
0.000 0.470 0.530
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.482 0.517
E32 Diseases of thymus
0.000 0.482 0.517
E30 Disorders of puberty, not elsewhere classified
0.000 0.482 0.517
E79 Disorders of purine and pyrimidine metabolism
0.001 0.483 0.516
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.000 0.486 0.514
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.000 0.486 0.514
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.000 0.486 0.514
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.000 0.486 0.514
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.486 0.514
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.000 0.486 0.514
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.000 0.486 0.514
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.000 0.486 0.514
E23.6 Other disorders of pituitary gland
0.000 0.487 0.513
E28.3 Primary ovarian failure
0.000 0.499 0.501
E14.1 With ketoacidosis
0.000 0.501 0.499
E73.9 Lactose intolerance, unspecified
0.000 0.501 0.499
E12.9 Without complications
0.000 0.501 0.499
E12.8 With unspecified complications
0.000 0.501 0.499
E12.7 With multiple complications
0.000 0.501 0.499
E12.6 With other specified complications
0.000 0.501 0.499
E12.5 With peripheral circulatory complications
0.000 0.501 0.499
E12.4 With neurological complications
0.000 0.501 0.499
E12.3 With ophthalmic complications
0.000 0.501 0.499
E12.2 With renal complications
0.000 0.501 0.499
E12.1 With ketoacidosis
0.000 0.501 0.499
E12.0 With coma
0.000 0.501 0.499
E24.8 Other Cushing's syndrome
0.000 0.503 0.497
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.000 0.503 0.497
E24.3 Ectopic ACTH syndrome
0.000 0.503 0.497
E24.1 Nelson's syndrome
0.000 0.503 0.497
E84 Cystic fibrosis
0.001 0.504 0.495
E06.3 Autoimmune thyroiditis
0.000 0.505 0.495
E31 Polyglandular dysfunction
0.000 0.506 0.494
E14.4 With neurological complications
0.000 0.509 0.491
E21.5 Disorder of parathyroid gland, unspecified
0.000 0.510 0.490
E74.9 Disorder of carbohydrate metabolism, unspecified
0.000 0.512 0.488
E74.8 Other specified disorders of carbohydrate metabolism
0.000 0.512 0.488
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
0.000 0.512 0.488
E74.2 Disorders of galactose metabolism
0.000 0.512 0.488
E74.1 Disorders of fructose metabolism
0.000 0.512 0.488
E14.2 Withrenal complications
0.000 0.512 0.488
C82.1 Mixed small cleaved and large cell, follicular
0.000 0.514 0.486
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.000 0.516 0.484
E74.0 Glycogen storage disease
0.000 0.520 0.480
C96.9 Malignant neoplasms of lymphoid, haematopoietic and related tissue, unspecified
0.000 0.524 0.475
C96.8 Histiocytic sarcoma
0.000 0.524 0.475
C96.7 Other specified malignant neoplasms of lymphoid, haematopoietic and related tissue
0.000 0.524 0.475
C96.6 Unifocal Langerhans-cell histiocytosis
0.000 0.524 0.475
C96.5 Multifocal and unisystemic Langerhans-cell histiocytosis
0.000 0.524 0.475
C96.4 Sarcoma of dendritic cells (accessory cells)
0.000 0.524 0.475
C96.3 True histiocytic lymphoma
0.000 0.524 0.475
C96.2 Malignant mast cell tumour
0.000 0.524 0.475
C96.1 Malignant histiocytosis
0.000 0.524 0.475
C96.0 Letterer-Siwe disease
0.000 0.524 0.475
E06.5 Other chronic thyroiditis
0.000 0.525 0.475
E06.4 Drug-induced thyroiditis
0.000 0.525 0.475
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.525 0.475
E06.0 Acute thyroiditis
0.000 0.525 0.475
K90.8 Other intestinal malabsorption
0.000 0.530 0.470
E26 Hyperaldosteronism
0.000 0.531 0.468
E11.7 With multiple complications
0.000 0.532 0.468
E73.8 Other lactose intolerance
0.000 0.532 0.468
E73.1 Secondary lactase deficiency
0.000 0.532 0.468
E73.0 Congenital lactase deficiency
0.000 0.532 0.468
E72.0 Disorders of amino-acid transport
0.001 0.532 0.467
C86.6 Primary cutaneous CD30-positive T-cell proliferations
0.000 0.536 0.464
C86.4 Blastic NK-cell lymphoma
0.000 0.536 0.464
C86.3 Subcutaneous panniculitis-like T-cell lymphoma
0.000 0.536 0.464
C86.2 Enteropathy-type (intestinal) T-cell lymphoma
0.000 0.536 0.464
C86.1 Hepatosplenic T-cell lymphoma
0.000 0.536 0.464
C86.0 Extranodal NK/T-cell lymphoma, nasal type
0.000 0.536 0.464
E72.9 Disorder of amino-acid metabolism, unspecified
0.001 0.545 0.455
E72.8 Other specified disorders of amino-acid metabolism
0.001 0.545 0.455
E72.5 Disorders of glycine metabolism
0.001 0.545 0.455
E72.4 Disorders of ornithine metabolism
0.001 0.545 0.455
E72.3 Disorders of lysine and hydroxylysine metabolism
0.001 0.545 0.455
E72.2 Disorders of urea cycle metabolism
0.001 0.545 0.455
E72.1 Disorders of sulphur-bearing amino-acid metabolism
0.001 0.545 0.455
K90.3 Pancreatic steatorrhoea
0.000 0.547 0.453
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.547 0.453
K90.1 Tropical sprue
0.000 0.547 0.453
E11.6 With other specified complications
0.000 0.548 0.452
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.000 0.548 0.452
E23.1 Drug-induced hypopituitarism
0.000 0.548 0.452
E88.8 Other specified metabolic disorders
0.000 0.551 0.449
C86.5 Angioimmunoblastic T-cell lymphoma
0.000 0.551 0.448
C94.7 Other specified leukaemias
0.000 0.552 0.448
C94.5 Acute myelofibrosis
0.000 0.552 0.448
C94.4 Acute panmyelosis
0.000 0.552 0.448
C94.3 Mast cell leukaemia
0.000 0.552 0.448
C94.2 Acute megakaryoblastic leukaemia
0.000 0.552 0.448
C94.1 Chronic erythraemia
0.000 0.552 0.448
C94.0 Acute erythraemia and erythroleukaemia
0.000 0.552 0.448
E75.5 Other lipid storage disorders
0.001 0.552 0.447
E75.6 Lipid storage disorder, unspecified
0.001 0.553 0.446
E75.4 Neuronal ceroid lipofuscinosis
0.001 0.553 0.446
E75.3 Sphingolipidosis, unspecified
0.001 0.553 0.446
E75.2 Other sphingolipidosis
0.001 0.553 0.446
E75.1 Other gangliosidosis
0.001 0.553 0.446
E75.0 GM2 gangliosidosis
0.001 0.553 0.446
E71.3 Disorders of fatty-acid metabolism
0.001 0.554 0.445
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified
0.001 0.554 0.445
E71.1 Other disorders of branched-chain amino-acid metabolism
0.001 0.554 0.445
E71.0 Maple-syrup-urine disease
0.001 0.554 0.445
E76.9 Disorder of glucosaminoglycan metabolism, unspecified
0.001 0.554 0.445
E76.8 Other disorders of glucosaminoglycan metabolism
0.001 0.554 0.445
E76.3 Mucopolysaccharidosis, unspecified
0.001 0.554 0.445
E76.2 Other mucopolysaccharidoses
0.001 0.554 0.445
E76.1 Mucopolysaccharidosis, type II
0.001 0.554 0.445
E76.0 Mucopolysaccharidosis, type I
0.001 0.554 0.445
E77.9 Disorder of glycoprotein metabolism, unspecified
0.001 0.554 0.445
E77.8 Other disorders of glycoprotein metabolism
0.001 0.554 0.445
E77.1 Defects in glycoprotein degradation
0.001 0.554 0.445
E77.0 Defects in posttranslational modification of lysosomal enzymes
0.001 0.554 0.445
E80 Disorders of porphyrin and bilirubin metabolism
0.000 0.555 0.445
E06.1 Subacute thyroiditis
0.000 0.557 0.443
C93.9 Monocytic leukaemia, unspecified
0.000 0.562 0.438
C93.7 Other monocytic leukaemia
0.000 0.562 0.438
C93.3 Juvenile myelomonocytic leukaemia
0.000 0.562 0.438
C93.2 Subacute monocytic leukaemia
0.000 0.562 0.438
C93.0 Acute monocytic leukaemia
0.000 0.562 0.438
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.000 0.566 0.433
E21.2 Other hyperparathyroidism
0.000 0.567 0.433
E06.9 Thyroiditis, unspecified
0.000 0.569 0.431
L40-L45 Papulosquamous disorders
0.000 0.570 0.430
E15 Nondiabetic hypoglycaemic coma
0.000 0.571 0.429
E44.1 Mild protein-energy malnutrition
0.000 0.575 0.424
E44.0 Moderate protein-energy malnutrition
0.000 0.575 0.424
K90.9 Intestinal malabsorption, unspecified
0.000 0.577 0.423
E70.9 Disorder of aromatic amino-acid metabolism, unspecified
0.001 0.578 0.421
E70.8 Other disorders of aromatic amino-acid metabolism
0.001 0.578 0.421
E70.2 Disorders of tyrosine metabolism
0.001 0.578 0.421
E70.1 Other hyperphenylalaninaemias
0.001 0.578 0.421
E70.0 Classical phenylketonuria
0.001 0.578 0.421
C84.4 Peripheral T-cell lymphoma
0.000 0.582 0.418
E28.9 Ovarian dysfunction, unspecified
0.000 0.582 0.418
E28.8 Other ovarian dysfunction
0.000 0.582 0.418
E28.1 Androgen excess
0.000 0.582 0.418
E28.0 Oestrogen excess
0.000 0.582 0.418
E88.2 Lipomatosis, not elsewhere classified
0.000 0.583 0.416
C94.6 Myelodysplastic and myeloproliferative disease, not elsewhere classified
0.000 0.591 0.409
C88.4 Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue [MALT-lymphoma]
0.000 0.601 0.398
E25.9 Adrenogenital disorder, unspecified
0.000 0.603 0.397
E25.8 Other adrenogenital disorders
0.000 0.603 0.397
C95.7 Other leukaemia of unspecified cell type
0.000 0.604 0.396
C95.2 Subacute leukaemia of unspecified cell type
0.000 0.604 0.396
C95.9 Leukaemia, unspecified
0.000 0.605 0.395
E70.3 Albinism
0.001 0.613 0.387
C93.1 Chronic monocytic leukaemia
0.000 0.614 0.386
E28.2 Polycystic ovarian syndrome
0.000 0.616 0.384
C88.9 Malignant immunoproliferative disease, unspecified
0.000 0.617 0.382
C88.7 Other malignant immunoproliferative diseases
0.000 0.617 0.382
C88.3 Immunoproliferative small intestinal disease
0.000 0.617 0.382
C88.2 Gamma heavy chain disease
0.000 0.617 0.382
C88.1 Alpha heavy chain disease
0.000 0.617 0.382
C95.1 Chronic leukaemia of unspecified cell type
0.000 0.619 0.381
E88.3 Tumour lysis syndrome
0.000 0.620 0.380
E20 Hypoparathyroidism
0.000 0.623 0.376
E30.9 Disorder of puberty, unspecified
0.000 0.629 0.371
E30.8 Other disorders of puberty
0.000 0.629 0.371
E30.1 Precocious puberty
0.000 0.629 0.371
E30.0 Delayed puberty
0.000 0.629 0.371
E32.9 Disease of thymus, unspecified
0.000 0.629 0.371
E32.8 Other diseases of thymus
0.000 0.629 0.371
E32.1 Abscess of thymus
0.000 0.629 0.371
E32.0 Persistent hyperplasia of thymus
0.000 0.629 0.371
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.629 0.371
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.629 0.371
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.629 0.371
E79.9 Disorder of purine and pyrimidine metabolism, unspecified
0.001 0.629 0.370
E79.8 Other disorders of purine and pyrimidine metabolism
0.001 0.629 0.370
E79.1 Lesch-Nyhan syndrome
0.001 0.629 0.370
E21.4 Other specified disorders of parathyroid gland
0.000 0.629 0.370
E65-E68 Obesity and other hyperalimentation
0.000 0.644 0.356
E84.8 Cystic fibrosis with other manifestations
0.001 0.644 0.355
E84.1 Cystic fibrosis with intestinal manifestations
0.001 0.644 0.355
E31.9 Polyglandular dysfunction, unspecified
0.000 0.646 0.354
E31.8 Other polyglandular dysfunction
0.000 0.646 0.354
E31.1 Polyglandular hyperfunction
0.000 0.646 0.354
E22 Hyperfunction of pituitary gland
0.000 0.657 0.342
E88.9 Metabolic disorder, unspecified
0.001 0.661 0.338
E11.2 With renal complications
0.000 0.662 0.338
E26.9 Hyperaldosteronism, unspecified
0.000 0.664 0.336
E26.8 Other hyperaldosteronism
0.000 0.664 0.336
E26.1 Secondary hyperaldosteronism
0.000 0.664 0.336
E80.6 Other disorders of bilirubin metabolism
0.000 0.666 0.334
E50-E64 Other nutritional deficiencies
0.000 0.667 0.333
E31.0 Autoimmune polyglandular failure
0.000 0.669 0.331
L43 Lichen planus
0.000 0.670 0.330
E16 Other disorders of pancreatic internal secretion
0.000 0.671 0.329
E11.8 With unspecified complications
0.000 0.678 0.321
E83 Disorders of mineral metabolism
0.184 0.679 0.138
E80.7 Disorder of bilirubin metabolism, unspecified
0.000 0.680 0.319
E80.5 Crigler-Najjar syndrome
0.000 0.680 0.319
E80.3 Defects of catalase and peroxydase
0.000 0.680 0.319
E80.0 Hereditary erythropoietic porphyria
0.000 0.680 0.319
L42 Pityriasis rosea
0.000 0.683 0.317
C60-C63 Malignant neoplasms of male genital organs
0.315 0.685 0.000
C95.0 Acute leukaemia of unspecified cell type
0.001 0.689 0.310
C91 Lymphoid leukaemia
0.001 0.690 0.309
L44 Other papulosquamous disorders
0.000 0.691 0.309
L45 Papulosquamous disorders in diseases classified elsewhere
0.000 0.691 0.309
E88.1 Lipodystrophy, not elsewhere classified
0.001 0.691 0.308
E84.9 Cystic fibrosis, unspecified
0.001 0.692 0.307
E29 Testicular dysfunction
0.001 0.693 0.306
C90 Multiple myeloma and malignant plasma cell neoplasms
0.005 0.697 0.298
E80.2 Other porphyria
0.000 0.699 0.300
C83.0 Small cell (diffuse)
0.001 0.702 0.298
E84.0 Cystic fibrosis with pulmonary manifestations
0.001 0.702 0.297
I83 Varicose veins of lower extremities
0.297 0.703 0.000
E80.1 Porphyria cutanea tarda
0.001 0.713 0.287
E26.0 Primary hyperaldosteronism
0.000 0.713 0.287
C91.9 Lymphoid leukaemia, unspecified
0.000 0.721 0.279
L41 Parapsoriasis
0.000 0.723 0.276
C92 Myeloid leukaemia
0.000 0.727 0.273
E34 Other endocrine disorders
0.001 0.729 0.270
E20.1 Pseudohypoparathyroidism
0.000 0.730 0.270
E20.0 Idiopathic hypoparathyroidism
0.000 0.730 0.270
E14.9 Without complications
0.000 0.730 0.270
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
0.001 0.734 0.265
L43.9 Lichen planus, unspecified
0.000 0.741 0.259
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.741 0.259
E27 Other disorders of adrenal gland
0.000 0.742 0.258
I83.0 Varicose veins of lower extremities with ulcer
0.257 0.743 0.000
C60 Malignant neoplasm of penis
0.257 0.743 0.000
E67 Other hyperalimentation
0.000 0.744 0.255
E68 Sequelae of hyperalimentation
0.000 0.744 0.255
E78.9 Disorder of lipoprotein metabolism, unspecified
0.000 0.745 0.254
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.754 0.246
E22.8 Other hyperfunction of pituitary gland
0.000 0.754 0.246
E61 Deficiency of other nutrient elements
0.000 0.755 0.244
E11.5 With peripheral circulatory complications
0.000 0.756 0.244
E56 Other vitamin deficiencies
0.000 0.757 0.243
E20.8 Other hypoparathyroidism
0.001 0.759 0.241
E51 Thiamine deficiency
0.000 0.761 0.239
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.761 0.239
E63 Other nutritional deficiencies
0.000 0.761 0.239
E50 Vitamin A deficiency
0.000 0.761 0.239
E60 Dietary zinc deficiency
0.000 0.761 0.239
E59 Dietary selenium deficiency
0.000 0.761 0.239
E52 Niacin deficiency [pellagra]
0.000 0.761 0.239
E16.1 Other hypoglycaemia
0.000 0.763 0.237
L43.3 Subacute (active) lichen planus
0.000 0.763 0.236
L43.2 Lichenoid drug reaction
0.000 0.763 0.236
L43.1 Bullous lichen planus
0.000 0.763 0.236
L43.0 Hypertrophic lichen planus
0.000 0.763 0.236
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.764 0.236
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.764 0.236
E16.4 Abnormal secretion of gastrin
0.000 0.764 0.236
E16.3 Increased secretion of glucagon
0.000 0.764 0.236
L43.8 Other lichen planus
0.000 0.765 0.235
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.000 0.767 0.232
C90.1 Plasma cell leukaemia
0.003 0.767 0.229
E83.8 Other disorders of mineral metabolism
0.132 0.769 0.099
E83.2 Disorders of zinc metabolism
0.132 0.769 0.099
E83.0 Disorders of copper metabolism
0.132 0.769 0.099
E58 Dietary calcium deficiency
0.000 0.770 0.230
E83.9 Disorder of mineral metabolism, unspecified
0.140 0.771 0.089
C63 Malignant neoplasm of other and unspecified male genital organs
0.229 0.771 0.000
C90.3 Solitary plasmacytoma
0.003 0.771 0.225
C92.1 Chronic myeloid leukaemia
0.000 0.772 0.228
E65 Localised adiposity
0.000 0.778 0.222
C91.8 Mature B-cell leukaemia Burkitt-type
0.001 0.778 0.222
C91.7 Other lymphoid leukaemia
0.001 0.778 0.222
C91.6 Prolymphocytic leukaemia of T-cell type
0.001 0.778 0.222
C91.3 Prolymphocytic leukaemia
0.001 0.778 0.222
C91.2 Subacute lymphocytic leukaemia
0.001 0.778 0.222
I83.2 Varicose veins of lower extremities with both ulcer and inflammation
0.222 0.778 0.000
L44.9 Papulosquamous disorder, unspecified
0.000 0.778 0.221
L44.8 Other specified papulosquamous disorders
0.000 0.778 0.221
L44.4 Infantile papular acrodermatitis [Giannotti-Crosti]
0.000 0.778 0.221
L44.3 Lichen ruber moniliformis
0.000 0.778 0.221
L44.2 Lichen striatus
0.000 0.778 0.221
L44.1 Lichen nitidus
0.000 0.778 0.221
L44.0 Pityriasis rubra pilaris
0.000 0.778 0.221
E27.9 Disorder of adrenal gland, unspecified
0.000 0.780 0.220
E29.8 Other testicular dysfunction
0.001 0.780 0.219
E29.0 Testicular hyperfunction
0.001 0.780 0.219
C88.0 Waldenstrom's macroglobulinaemia
0.001 0.780 0.219
E88.0 Disorders of plasma-protein metabolism, not elsewhere classified
0.000 0.783 0.217
C91.5 Adult T-cell leukaemia
0.001 0.790 0.209
E22.1 Hyperprolactinaemia
0.000 0.790 0.209
E80.4 Gilbert's syndrome
0.000 0.792 0.208
C60.9 Penis, unspecified
0.206 0.794 0.000
H00.1 Chalazion
0.202 0.798 0.000
E29.9 Testicular dysfunction, unspecified
0.001 0.799 0.200
E61.2 Magnesium deficiency
0.000 0.801 0.199
E34.3 Short stature, not elsewhere classified
0.001 0.801 0.198
L41.9 Parapsoriasis, unspecified
0.000 0.801 0.198
L41.8 Other parapsoriasis
0.000 0.801 0.198
L41.5 Retiform parapsoriasis
0.000 0.801 0.198
L41.4 Large plaque parapsoriasis
0.000 0.801 0.198
L41.3 Small plaque parapsoriasis
0.000 0.801 0.198
L41.2 Lymphomatoid papulosis
0.000 0.801 0.198
L41.0 Pityriasis lichenoides et varioliformis acuta
0.000 0.801 0.198
C92.8 Acute myeloid leukaemia with multilineage dysplasia
0.000 0.804 0.196
C92.6 Acute myeloid leukaemia with 11q23-abnormality
0.000 0.804 0.196
C92.3 Myeloid sarcoma
0.000 0.804 0.196
C92.2 Subacute myeloid leukaemia
0.000 0.804 0.196
E54 Ascorbic acid deficiency
0.000 0.805 0.195
E34.8 Other specified endocrine disorders
0.001 0.805 0.194
E34.5 Androgen resistance syndrome
0.001 0.806 0.194
E34.4 Constitutional tall stature
0.001 0.806 0.194
E34.2 Ectopic hormone secretion, not elsewhere classified
0.001 0.806 0.194
E34.1 Other hypersecretion of intestinal hormones
0.001 0.806 0.194
E23.0 Hypopituitarism
0.000 0.808 0.191
C60.0 Prepuce
0.191 0.809 0.000
C60.1 Glans penis
0.190 0.810 0.000
E21.0 Primary hyperparathyroidism
0.000 0.811 0.189
C92.5 Acute myelomonocytic leukaemia
0.001 0.814 0.185
E27.5 Adrenomedullary hyperfunction
0.000 0.814 0.185
E27.0 Other adrenocortical overactivity
0.000 0.814 0.185
C60.8 Overlapping lesion of penis
0.184 0.816 0.000
C60.2 Body of penis
0.184 0.816 0.000
E67.8 Other specified hyperalimentation
0.000 0.817 0.183
E67.3 Hypervitaminosis D
0.000 0.817 0.183
E67.2 Megavitamin-B6 syndrome
0.000 0.817 0.183
E67.1 Hypercarotenaemia
0.000 0.817 0.183
E67.0 Hypervitaminosis A
0.000 0.817 0.183

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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