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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs2523488
log Bayes Factor = 47.9703
Chromosome 6   position 31,350,855  (GRCh37) Explore rs2523488 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E10.9 Without complications
0.000 0.000 1.000
K90.0 Coeliac disease
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
G35 Multiple sclerosis
1.000 0.000 0.000
E10-E14 Diabetes mellitus
0.000 0.000 1.000
E00-E07 Disorders of thyroid gland
0.000 0.000 1.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.000 1.000
E03.9 Hypothyroidism, unspecified
0.000 0.000 1.000
M06.9 Rheumatoid arthritis, unspecified
0.000 0.000 1.000
E78.0 Pure hypercholesterolaemia
0.000 0.000 1.000
E03 Other hypothyroidism
0.000 0.000 1.000
E10.3 With ophthalmic complications
0.000 0.000 1.000
E83.1 Disorders of iron metabolism
1.000 0.000 0.000
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)
0.000 0.001 0.999
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.000 0.001 0.999
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.002 0.998
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)
0.000 0.002 0.998
E14 Unspecified diabetes mellitus
0.000 0.003 0.997
E05.9 Thyrotoxicosis, unspecified
0.000 0.005 0.995
E70-E90 Metabolic disorders
0.000 0.005 0.995
E11 Non-insulin-dependent diabetes mellitus
0.000 0.006 0.994
E14.9 Without complications
0.000 0.010 0.990
E10.1 With ketoacidosis
0.000 0.012 0.988
K51 Ulcerative colitis
0.982 0.018 0.000
E11.9 Without complications
0.000 0.018 0.982
K51.9 Ulcerative colitis, unspecified
0.978 0.022 0.000
M06.94 Rheumatoid arthritis, unspecified (Hand)
0.000 0.023 0.977
K51.3 Ulcerative (chronic) rectosigmoiditis
0.966 0.034 0.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.058 0.942
K51.4 Pseudopolyposis of colon
0.941 0.059 0.000
M06.96 Rheumatoid arthritis, unspecified (Lower leg)
0.000 0.062 0.938
E10.4 With neurological complications
0.000 0.065 0.935
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.067 0.933
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.000 0.073 0.927
K51.8 Other ulcerative colitis
0.926 0.074 0.000
E11.1 With ketoacidosis
0.000 0.077 0.923
I10 Essential (primary) hypertension
0.000 0.091 0.909
E16 Other disorders of pancreatic internal secretion
0.000 0.099 0.901
E14.3 With ophthalmic complications
0.000 0.101 0.899
E07 Other disorders of thyroid
0.000 0.103 0.897
E78.8 Other disorders of lipoprotein metabolism
0.000 0.109 0.891
M06.92 Rheumatoid arthritis, unspecified (Upper arm)
0.000 0.109 0.891
E11.0 With coma
0.000 0.110 0.890
E10.8 With unspecified complications
0.000 0.130 0.870
M06.91 Rheumatoid arthritis, unspecified (Shoulder region)
0.000 0.133 0.867
K51.2 Ulcerative (chronic) proctitis
0.861 0.139 0.000
E16.2 Hypoglycaemia, unspecified
0.000 0.146 0.854
K51.0 Ulcerative (chronic) enterocolitis
0.853 0.147 0.000
E10.2 With renal complications
0.000 0.150 0.850
E74 Other disorders of carbohydrate metabolism
0.000 0.158 0.842
E07.9 Disorder of thyroid, unspecified
0.000 0.160 0.840
K51.5 Mucosal proctocolitis
0.839 0.161 0.000
G35-G37 Demyelinating diseases of the central nervous system
0.834 0.166 0.000
M06.93 Rheumatoid arthritis, unspecified (Forearm)
0.000 0.170 0.830
E85 Amyloidosis
0.000 0.172 0.828
E78.5 Hyperlipidaemia, unspecified
0.000 0.181 0.819
E78.1 Pure hyperglyceridaemia
0.000 0.191 0.809
G37 Other demyelinating diseases of central nervous system
0.790 0.210 0.000
E20-E35 Disorders of other endocrine glands
0.000 0.219 0.781
E10.0 With coma
0.000 0.237 0.763
E78.2 Mixed hyperlipidaemia
0.000 0.239 0.761
E10.5 With peripheral circulatory complications
0.000 0.241 0.759
E10.6 With other specified complications
0.000 0.241 0.759
G37.9 Demyelinating disease of central nervous system, unspecified
0.751 0.249 0.000
E14.4 With neurological complications
0.000 0.249 0.751
E16.1 Other hypoglycaemia
0.000 0.250 0.750
M06.97 Rheumatoid arthritis, unspecified (Ankle and foot)
0.000 0.251 0.749
E78.4 Other hyperlipidaemia
0.000 0.259 0.741
E05.8 Other thyrotoxicosis
0.000 0.262 0.738
E11.2 With renal complications
0.000 0.266 0.734
E74.3 Other disorders of intestinal carbohydrate absorption
0.000 0.268 0.732
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.274 0.726
M06.98 Rheumatoid arthritis, unspecified (Other)
0.000 0.275 0.725
E10.7 With multiple complications
0.000 0.283 0.717
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.283 0.717
E00 Congenital iodine-deficiency syndrome
0.000 0.283 0.717
E12 Malnutrition-related diabetes mellitus
0.000 0.283 0.717
E03.5 Myxoedema coma
0.000 0.283 0.717
E03.4 Atrophy of thyroid (acquired)
0.000 0.283 0.717
E03.3 Postinfectious hypothyroidism
0.000 0.283 0.717
E03.1 Congenital hypothyroidism without goitre
0.000 0.283 0.717
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.283 0.717
E78.6 Lipoprotein deficiency
0.000 0.284 0.716
E78.3 Hyperchylomicronaemia
0.000 0.284 0.716
E14.5 With peripheral circulatory complications
0.000 0.284 0.716
E05.5 Thyroid crisis or storm
0.000 0.284 0.716
E05.4 Thyrotoxicosis factitia
0.000 0.284 0.716
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.284 0.716
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.284 0.716
E14.8 With unspecified complications
0.000 0.285 0.715
E14.7 With multiple complications
0.000 0.285 0.715
E14.6 With other specified complications
0.000 0.285 0.715
E14.2 Withrenal complications
0.000 0.285 0.715
E14.1 With ketoacidosis
0.000 0.285 0.715
E14.0 With coma
0.000 0.285 0.715
E77 Disorders of glycoprotein metabolism
0.000 0.287 0.713
E76 Disorders of glycosaminoglycan metabolism
0.000 0.287 0.713
E72 Other disorders of amino-acid metabolism
0.000 0.287 0.713
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.000 0.287 0.713
E70 Disorders of aromatic amino-acid metabolism
0.000 0.287 0.713
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.000 0.287 0.713
E11.7 With multiple complications
0.000 0.287 0.713
E40-E46 Malnutrition
0.000 0.297 0.703
E84 Cystic fibrosis
0.000 0.298 0.702
E06 Thyroiditis
0.000 0.298 0.702
E79 Disorders of purine and pyrimidine metabolism
0.000 0.298 0.701
E28 Ovarian dysfunction
0.000 0.302 0.698
E85.9 Amyloidosis, unspecified
0.000 0.311 0.689
E11.5 With peripheral circulatory complications
0.000 0.314 0.686
E11.3 With ophthalmic complications
0.000 0.321 0.679
E03.8 Other specified hypothyroidism
0.000 0.323 0.677
E15 Nondiabetic hypoglycaemic coma
0.000 0.324 0.676
E13 Other specified diabetes mellitus
0.000 0.326 0.674
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.000 0.326 0.674
I10-I15 Hypertensive diseases
0.000 0.327 0.673
K51.1 Ulcerative (chronic) ileocolitis
0.664 0.335 0.000
G37.8 Other specified demyelinating diseases of central nervous system
0.662 0.338 0.000
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.341 0.659
E28.2 Polycystic ovarian syndrome
0.000 0.345 0.655
E11.8 With unspecified complications
0.000 0.345 0.654
E23 Hypofunction and other disorders of pituitary gland
0.000 0.346 0.654
E85.4 Organ-limited amyloidosis
0.000 0.349 0.650
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.354 0.646
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.354 0.646
E16.4 Abnormal secretion of gastrin
0.000 0.354 0.646
E16.3 Increased secretion of glucagon
0.000 0.354 0.646
E07.1 Dyshormogenetic goitre
0.000 0.357 0.643
E07.0 Hypersecretion of calcitonin
0.000 0.357 0.643
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.366 0.634
E73 Lactose intolerance
0.000 0.368 0.632
E11.6 With other specified complications
0.000 0.372 0.628
I12 Hypertensive renal disease
0.000 0.388 0.612
M45.X9 Ankylosing spondylitis (Site unspecified)
0.000 0.390 0.610
M06 Other rheumatoid arthritis
0.000 0.390 0.610
E24 Cushing's syndrome
0.000 0.392 0.608
E74.9 Disorder of carbohydrate metabolism, unspecified
0.000 0.396 0.603
E74.8 Other specified disorders of carbohydrate metabolism
0.000 0.396 0.603
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
0.000 0.396 0.603
E74.2 Disorders of galactose metabolism
0.000 0.396 0.603
E74.1 Disorders of fructose metabolism
0.000 0.396 0.603
E74.0 Glycogen storage disease
0.000 0.396 0.603
E83 Disorders of mineral metabolism
0.397 0.399 0.204
E29 Testicular dysfunction
0.000 0.401 0.599
G36 Other acute disseminated demyelination
0.598 0.402 0.000
E85.8 Other amyloidosis
0.000 0.406 0.594
E85.2 Heredofamilial amyloidosis, unspecified
0.000 0.406 0.594
E85.1 Neuropathic heredofamilial amyloidosis
0.000 0.406 0.594
E85.0 Nonneuropathic heredofamilial amyloidosis
0.000 0.406 0.594
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.000 0.412 0.587
E22 Hyperfunction of pituitary gland
0.000 0.421 0.579
E07.8 Other specified disorders of thyroid
0.000 0.431 0.568
G37.5 Concentric sclerosis [Balo]
0.567 0.433 0.000
G37.4 Subacute necrotising myelitis
0.567 0.433 0.000
G37.2 Central pontine myelinolysis
0.567 0.433 0.000
G37.1 Central demyelination of corpus callosum
0.567 0.433 0.000
G37.0 Diffuse sclerosis
0.567 0.433 0.000
I12.9 Hypertensive renal disease without renal failure
0.000 0.435 0.565
M06.3 Rheumatoid nodule
0.000 0.436 0.564
E85.3 Secondary systemic amyloidosis
0.000 0.436 0.564
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.440 0.560
E32 Diseases of thymus
0.000 0.440 0.560
E31 Polyglandular dysfunction
0.000 0.440 0.560
E30 Disorders of puberty, not elsewhere classified
0.000 0.440 0.560
E25 Adrenogenital disorders
0.000 0.440 0.560
E23.7 Disorder of pituitary gland, unspecified
0.000 0.445 0.555
E26 Hyperaldosteronism
0.000 0.452 0.548
E50-E64 Other nutritional deficiencies
0.000 0.454 0.546
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.000 0.463 0.537
I15 Secondary hypertension
0.000 0.481 0.519
E78.9 Disorder of lipoprotein metabolism, unspecified
0.000 0.483 0.517
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.000 0.486 0.514
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.000 0.486 0.514
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.000 0.486 0.514
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.000 0.486 0.514
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.486 0.514
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.000 0.486 0.514
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.000 0.486 0.514
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.000 0.486 0.514
E12.9 Without complications
0.000 0.486 0.514
E12.8 With unspecified complications
0.000 0.486 0.514
E12.7 With multiple complications
0.000 0.486 0.514
E12.6 With other specified complications
0.000 0.486 0.514
E12.5 With peripheral circulatory complications
0.000 0.486 0.514
E12.4 With neurological complications
0.000 0.486 0.514
E12.3 With ophthalmic complications
0.000 0.486 0.514
E12.2 With renal complications
0.000 0.486 0.514
E12.1 With ketoacidosis
0.000 0.486 0.514
E12.0 With coma
0.000 0.486 0.514
E70.9 Disorder of aromatic amino-acid metabolism, unspecified
0.000 0.488 0.511
E70.8 Other disorders of aromatic amino-acid metabolism
0.000 0.488 0.511
E70.3 Albinism
0.000 0.488 0.511
E70.2 Disorders of tyrosine metabolism
0.000 0.488 0.511
E70.1 Other hyperphenylalaninaemias
0.000 0.488 0.511
E70.0 Classical phenylketonuria
0.000 0.488 0.511
E71.3 Disorders of fatty-acid metabolism
0.000 0.488 0.511
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified
0.000 0.488 0.511
E71.1 Other disorders of branched-chain amino-acid metabolism
0.000 0.488 0.511
E71.0 Maple-syrup-urine disease
0.000 0.488 0.511
E72.9 Disorder of amino-acid metabolism, unspecified
0.000 0.488 0.511
E72.8 Other specified disorders of amino-acid metabolism
0.000 0.488 0.511
E72.5 Disorders of glycine metabolism
0.000 0.488 0.511
E72.4 Disorders of ornithine metabolism
0.000 0.488 0.511
E72.3 Disorders of lysine and hydroxylysine metabolism
0.000 0.488 0.511
E72.2 Disorders of urea cycle metabolism
0.000 0.488 0.511
E72.1 Disorders of sulphur-bearing amino-acid metabolism
0.000 0.488 0.511
E72.0 Disorders of amino-acid transport
0.000 0.488 0.511
E76.9 Disorder of glucosaminoglycan metabolism, unspecified
0.000 0.488 0.511
E76.8 Other disorders of glucosaminoglycan metabolism
0.000 0.488 0.511
E76.3 Mucopolysaccharidosis, unspecified
0.000 0.488 0.511
E76.2 Other mucopolysaccharidoses
0.000 0.488 0.511
E76.1 Mucopolysaccharidosis, type II
0.000 0.488 0.511
E76.0 Mucopolysaccharidosis, type I
0.000 0.488 0.511
E77.9 Disorder of glycoprotein metabolism, unspecified
0.000 0.488 0.511
E77.8 Other disorders of glycoprotein metabolism
0.000 0.488 0.511
E77.1 Defects in glycoprotein degradation
0.000 0.488 0.511
E77.0 Defects in posttranslational modification of lysosomal enzymes
0.000 0.488 0.511
E06.3 Autoimmune thyroiditis
0.000 0.491 0.509
E89.3 Postprocedural hypopituitarism
0.000 0.492 0.508
M06.34 Rheumatoid nodule (Hand)
0.000 0.495 0.505
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.496 0.504
E45 Retarded development following protein-energy malnutrition
0.000 0.496 0.504
E43 Unspecified severe protein-energy malnutrition
0.000 0.496 0.504
E42 Marasmic kwashiorkor
0.000 0.496 0.504
E41 Nutritional marasmus
0.000 0.496 0.504
E40 Kwashiorkor
0.000 0.496 0.504
E84.8 Cystic fibrosis with other manifestations
0.000 0.496 0.503
E84.1 Cystic fibrosis with intestinal manifestations
0.000 0.496 0.503
E84.0 Cystic fibrosis with pulmonary manifestations
0.000 0.496 0.503
E06.5 Other chronic thyroiditis
0.000 0.497 0.503
E06.4 Drug-induced thyroiditis
0.000 0.497 0.503
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.497 0.503
E06.1 Subacute thyroiditis
0.000 0.497 0.503
E06.0 Acute thyroiditis
0.000 0.497 0.503
E79.9 Disorder of purine and pyrimidine metabolism, unspecified
0.000 0.497 0.503
E79.8 Other disorders of purine and pyrimidine metabolism
0.000 0.497 0.503
E79.1 Lesch-Nyhan syndrome
0.000 0.497 0.503
E28.9 Ovarian dysfunction, unspecified
0.000 0.499 0.500
E28.8 Other ovarian dysfunction
0.000 0.499 0.500
E28.1 Androgen excess
0.000 0.499 0.500
E28.0 Oestrogen excess
0.000 0.499 0.500
M45 Ankylosing spondylitis
0.000 0.500 0.500
E23.6 Other disorders of pituitary gland
0.000 0.503 0.497
E84.9 Cystic fibrosis, unspecified
0.000 0.508 0.492
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.508 0.491
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
0.000 0.509 0.491
E23.2 Diabetes insipidus
0.000 0.510 0.490
E46 Unspecified protein-energy malnutrition
0.000 0.510 0.490
E24.9 Cushing's syndrome, unspecified
0.000 0.515 0.484
E13.8 With unspecified complications
0.000 0.517 0.483
E13.7 With multiple complications
0.000 0.517 0.483
E13.6 With other specified complications
0.000 0.517 0.483
E13.5 With peripheral circulatory complications
0.000 0.517 0.483
E13.4 With neurological complications
0.000 0.517 0.483
E13.3 With ophthalmic complications
0.000 0.517 0.483
E13.2 With renal complications
0.000 0.517 0.483
E13.1 With ketoacidosis
0.000 0.517 0.483
E13.0 With coma
0.000 0.517 0.483
E75.6 Lipid storage disorder, unspecified
0.000 0.517 0.483
E75.4 Neuronal ceroid lipofuscinosis
0.000 0.517 0.483
E75.3 Sphingolipidosis, unspecified
0.000 0.517 0.483
E75.2 Other sphingolipidosis
0.000 0.517 0.483
E75.1 Other gangliosidosis
0.000 0.517 0.483
E75.0 GM2 gangliosidosis
0.000 0.517 0.483
G37.3 Acute transverse myelitis in demyelinating disease of central nervous system
0.483 0.517 0.000
I13 Hypertensive heart and renal disease
0.000 0.518 0.482
E06.9 Thyroiditis, unspecified
0.000 0.518 0.482
E80 Disorders of porphyrin and bilirubin metabolism
0.000 0.522 0.478
I11 Hypertensive heart disease
0.000 0.522 0.478
E34 Other endocrine disorders
0.000 0.525 0.475
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.000 0.531 0.469
E23.1 Drug-induced hypopituitarism
0.000 0.531 0.469
E29.1 Testicular hypofunction
0.000 0.532 0.468
E61 Deficiency of other nutrient elements
0.000 0.538 0.462
E21.3 Hyperparathyroidism, unspecified
0.000 0.539 0.461
E20 Hypoparathyroidism
0.000 0.545 0.455
M45.X0 Ankylosing spondylitis (Multiple sites in spine)
0.000 0.545 0.455
E65-E68 Obesity and other hyperalimentation
0.000 0.546 0.454
E73.8 Other lactose intolerance
0.000 0.547 0.453
E73.1 Secondary lactase deficiency
0.000 0.547 0.453
E73.0 Congenital lactase deficiency
0.000 0.547 0.453
E89.6 Postprocedural adrenocortical(-medullary) hypofunction
0.000 0.547 0.453
E11.4 With neurological complications
0.000 0.548 0.452
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.000 0.548 0.452
M06.32 Rheumatoid nodule (Upper arm)
0.000 0.548 0.452
I12.0 Hypertensive renal disease with renal failure
0.000 0.549 0.451
E75.5 Other lipid storage disorders
0.000 0.556 0.444
E13.9 Without complications
0.000 0.560 0.440
M06.37 Rheumatoid nodule (Ankle and foot)
0.000 0.562 0.438
M06.8 Other specified rheumatoid arthritis
0.000 0.563 0.437
M06.2 Rheumatoid bursitis
0.000 0.563 0.437
M06.1 Adult-onset Still's disease
0.000 0.563 0.437
E24.8 Other Cushing's syndrome
0.000 0.564 0.436
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.000 0.564 0.436
E24.3 Ectopic ACTH syndrome
0.000 0.564 0.436
E24.2 Drug-induced Cushing's syndrome
0.000 0.564 0.436
E24.1 Nelson's syndrome
0.000 0.564 0.436
E24.0 Pituitary-dependent Cushing's disease
0.000 0.564 0.436
E83.9 Disorder of mineral metabolism, unspecified
0.285 0.569 0.146
E83.8 Other disorders of mineral metabolism
0.285 0.569 0.146
E83.2 Disorders of zinc metabolism
0.285 0.569 0.146
E83.0 Disorders of copper metabolism
0.285 0.569 0.146
E29.9 Testicular dysfunction, unspecified
0.000 0.570 0.429
E29.8 Other testicular dysfunction
0.000 0.570 0.429
E29.0 Testicular hyperfunction
0.000 0.570 0.429
G36.9 Acute disseminated demyelination, unspecified
0.429 0.571 0.000
G36.8 Other specified acute disseminated demyelination
0.429 0.571 0.000
G36.1 Acute and subacute haemorrhagic leukoencephalitis [Hurst]
0.429 0.571 0.000
G36.0 Neuromyelitis optica [Devic]
0.429 0.571 0.000
E28.3 Primary ovarian failure
0.000 0.575 0.425
E23.0 Hypopituitarism
0.000 0.575 0.425
M45.X2 Ankylosing spondylitis (Cervical region)
0.000 0.578 0.422
E89.9 Postprocedural endocrine and metabolic disorder, unspecified
0.000 0.579 0.421
E89.8 Other postprocedural endocrine and metabolic disorders
0.000 0.579 0.421
E89.5 Postprocedural testicular hypofunction
0.000 0.579 0.421
E89.1 Postprocedural hypoinsulinaemia
0.000 0.579 0.421
E89.4 Postprocedural ovarian failure
0.000 0.579 0.420
E22.0 Acromegaly and pituitary gigantism
0.000 0.580 0.420
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.585 0.415
E22.8 Other hyperfunction of pituitary gland
0.000 0.585 0.415
E61.1 Iron deficiency
0.000 0.589 0.411
I15.1 Hypertension secondary to other renal disorders
0.000 0.591 0.409
M06.39 Rheumatoid nodule (Site unspecified)
0.000 0.595 0.404
M06.38 Rheumatoid nodule (Other)
0.000 0.595 0.404
M06.36 Rheumatoid nodule (Lower leg)
0.000 0.595 0.404
M06.35 Rheumatoid nodule (Pelvic region and thigh)
0.000 0.595 0.404
M06.33 Rheumatoid nodule (Forearm)
0.000 0.595 0.404
M06.31 Rheumatoid nodule (Shoulder region)
0.000 0.595 0.404
M06.30 Rheumatoid nodule (Multiple sites)
0.000 0.595 0.404
M06.4 Inflammatory polyarthropathy
0.000 0.596 0.404
E25.9 Adrenogenital disorder, unspecified
0.000 0.598 0.402
E25.8 Other adrenogenital disorders
0.000 0.598 0.402
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.000 0.598 0.402
E30.9 Disorder of puberty, unspecified
0.000 0.598 0.402
E30.8 Other disorders of puberty
0.000 0.598 0.402
E30.1 Precocious puberty
0.000 0.598 0.402
E30.0 Delayed puberty
0.000 0.598 0.402
E31.9 Polyglandular dysfunction, unspecified
0.000 0.598 0.402
E31.8 Other polyglandular dysfunction
0.000 0.598 0.402
E31.1 Polyglandular hyperfunction
0.000 0.598 0.402
E31.0 Autoimmune polyglandular failure
0.000 0.598 0.402
E32.9 Disease of thymus, unspecified
0.000 0.598 0.402
E32.8 Other diseases of thymus
0.000 0.598 0.402
E32.1 Abscess of thymus
0.000 0.598 0.402
E32.0 Persistent hyperplasia of thymus
0.000 0.598 0.402
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.598 0.402
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.598 0.402
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.598 0.402
E26.9 Hyperaldosteronism, unspecified
0.000 0.607 0.393
E26.8 Other hyperaldosteronism
0.000 0.607 0.393
E26.1 Secondary hyperaldosteronism
0.000 0.607 0.393
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.608 0.391
E63 Other nutritional deficiencies
0.000 0.608 0.391
E56 Other vitamin deficiencies
0.000 0.608 0.391
E51 Thiamine deficiency
0.000 0.608 0.391
E50 Vitamin A deficiency
0.000 0.608 0.391
E60 Dietary zinc deficiency
0.000 0.608 0.391
E59 Dietary selenium deficiency
0.000 0.608 0.391
E58 Dietary calcium deficiency
0.000 0.608 0.391
E54 Ascorbic acid deficiency
0.000 0.608 0.391
E52 Niacin deficiency [pellagra]
0.000 0.608 0.391
E83.3 Disorders of phosphorus metabolism
0.290 0.614 0.096
E22.1 Hyperprolactinaemia
0.000 0.614 0.386
E21.5 Disorder of parathyroid gland, unspecified
0.000 0.615 0.385
E21.4 Other specified disorders of parathyroid gland
0.000 0.615 0.385
E21.2 Other hyperparathyroidism
0.000 0.615 0.385
E26.0 Primary hyperaldosteronism
0.000 0.618 0.381
I15.9 Seconday hypertension, unspecified
0.000 0.628 0.372
I15.8 Other secondary hypertension
0.000 0.628 0.372
I15.2 Hypertension secondary to endocrine disorders
0.000 0.628 0.372
I15.0 Renovascular hypertension
0.000 0.628 0.372
E73.9 Lactose intolerance, unspecified
0.000 0.628 0.372
E88 Other metabolic disorders
0.000 0.634 0.366
E44.1 Mild protein-energy malnutrition
0.000 0.638 0.361
E44.0 Moderate protein-energy malnutrition
0.000 0.638 0.361
M45.X8 Ankylosing spondylitis (Sacral and sacrococcygeal region)
0.000 0.642 0.358
M45.X7 Ankylosing spondylitis (Lumbosacral region)
0.000 0.642 0.358
M45.X6 Ankylosing spondylitis (Lumbar region)
0.000 0.642 0.358
M45.X5 Ankylosing spondylitis (Thoracolumbar region)
0.000 0.642 0.358
M45.X4 Ankylosing spondylitis (Thoracic region)
0.000 0.642 0.358
M45.X3 Ankylosing spondylitis (Cervicothoracic region)
0.000 0.642 0.358
M45.X1 Ankylosing spondylitis (Occipito-atlanto-axial region)
0.000 0.642 0.358
I11.0 Hypertensive heart disease with (congestive) heart failure
0.000 0.646 0.354
I13.9 Hypertensive heart and renal disease, unspecified
0.000 0.654 0.346
I13.2 Hypertensive heart and renal disease with both (congestive) heart failure and renal failure
0.000 0.654 0.346
I13.1 Hypertensive heart and renal disease with renal failure
0.000 0.654 0.346
I13.0 Hypertensive heart and renal disease with (congestive) heart failure
0.000 0.654 0.346
E80.7 Disorder of bilirubin metabolism, unspecified
0.000 0.657 0.343
E80.5 Crigler-Najjar syndrome
0.000 0.657 0.343
E80.3 Defects of catalase and peroxydase
0.000 0.657 0.343
E80.2 Other porphyria
0.000 0.657 0.343
E80.0 Hereditary erythropoietic porphyria
0.000 0.657 0.343
E34.5 Androgen resistance syndrome
0.000 0.659 0.340
E34.4 Constitutional tall stature
0.000 0.659 0.340
E34.3 Short stature, not elsewhere classified
0.000 0.659 0.340
E34.2 Ectopic hormone secretion, not elsewhere classified
0.000 0.659 0.340
E34.1 Other hypersecretion of intestinal hormones
0.000 0.659 0.340
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.000 0.661 0.339
E61.9 Deficiency of nutrient element, unspecified
0.000 0.668 0.331
E61.8 Deficiency of other specified nutrient elements
0.000 0.668 0.331
E61.7 Deficiency of multiple nutrient elements
0.000 0.668 0.331
E61.6 Vanadium deficiency
0.000 0.668 0.331
E61.5 Molybdenum deficiency
0.000 0.668 0.331
E61.4 Chromium deficiency
0.000 0.668 0.331
E61.3 Manganese deficiency
0.000 0.668 0.331
E61.0 Copper deficiency
0.000 0.668 0.331
E80.6 Other disorders of bilirubin metabolism
0.000 0.669 0.331
E80.1 Porphyria cutanea tarda
0.000 0.672 0.327
E34.0 Carcinoid syndrome
0.000 0.673 0.327
E20.8 Other hypoparathyroidism
0.000 0.674 0.326
E20.1 Pseudohypoparathyroidism
0.000 0.674 0.326
E20.0 Idiopathic hypoparathyroidism
0.000 0.674 0.326
I11.9 Hypertensive heart disease without (congestive) heart failure
0.000 0.674 0.326
E67 Other hyperalimentation
0.000 0.674 0.326
E68 Sequelae of hyperalimentation
0.000 0.674 0.326
E65 Localised adiposity
0.000 0.677 0.323
E34.8 Other specified endocrine disorders
0.000 0.680 0.320
M06.19 Adult-onset Still's disease (Site unspecified)
0.000 0.686 0.313
M06.18 Adult-onset Still's disease (Other)
0.000 0.686 0.313
M06.17 Adult-onset Still's disease (Ankle and foot)
0.000 0.686 0.313
M06.16 Adult-onset Still's disease (Lower leg)
0.000 0.686 0.313
M06.15 Adult-onset Still's disease (Pelvic region and thigh)
0.000 0.686 0.313
M06.14 Adult-onset Still's disease (Hand)
0.000 0.686 0.313
M06.13 Adult-onset Still's disease (Forearm)
0.000 0.686 0.313
M06.12 Adult-onset Still's disease (Upper arm)
0.000 0.686 0.313
M06.11 Adult-onset Still's disease (Shoulder region)
0.000 0.686 0.313
M06.10 Adult-onset Still's disease (Multiple sites)
0.000 0.686 0.313
M06.29 Rheumatoid bursitis (Site unspecified)
0.000 0.686 0.313
M06.28 Rheumatoid bursitis (Other)
0.000 0.686 0.313
M06.27 Rheumatoid bursitis (Ankle and foot)
0.000 0.686 0.313
M06.26 Rheumatoid bursitis (Lower leg)
0.000 0.686 0.313
M06.25 Rheumatoid bursitis (Pelvic region and thigh)
0.000 0.686 0.313
M06.24 Rheumatoid bursitis (Hand)
0.000 0.686 0.313
M06.23 Rheumatoid bursitis (Forearm)
0.000 0.686 0.313
M06.22 Rheumatoid bursitis (Upper arm)
0.000 0.686 0.313
M06.21 Rheumatoid bursitis (Shoulder region)
0.000 0.686 0.313
M06.20 Rheumatoid bursitis (Multiple sites)
0.000 0.686 0.313
M06.89 Other specified rheumatoid arthritis (Site unspecified)
0.000 0.686 0.313
M06.88 Other specified rheumatoid arthritis (Other)
0.000 0.686 0.313
M06.87 Other specified rheumatoid arthritis (Ankle and foot)
0.000 0.686 0.313
M06.86 Other specified rheumatoid arthritis (Lower leg)
0.000 0.686 0.313
M06.85 Other specified rheumatoid arthritis (Pelvic region and thigh)
0.000 0.686 0.313
M06.84 Other specified rheumatoid arthritis (Hand)
0.000 0.686 0.313
M06.83 Other specified rheumatoid arthritis (Forearm)
0.000 0.686 0.313
M06.82 Other specified rheumatoid arthritis (Upper arm)
0.000 0.686 0.313
M06.81 Other specified rheumatoid arthritis (Shoulder region)
0.000 0.686 0.313
M06.80 Other specified rheumatoid arthritis (Multiple sites)
0.000 0.686 0.313
M06.0 Seronegative rheumatoid arthritis
0.000 0.692 0.308
E61.2 Magnesium deficiency
0.000 0.693 0.307
E34.9 Endocrine disorder, unspecified
0.000 0.698 0.302
J45.9 Asthma, unspecified
0.000 0.698 0.302
E83.5 Disorders of calcium metabolism
0.283 0.699 0.018
E89.2 Postprocedural hypoparathyroidism
0.000 0.702 0.297
M06.48 Inflammatory polyarthropathy (Other)
0.000 0.710 0.290
M06.47 Inflammatory polyarthropathy (Ankle and foot)
0.000 0.710 0.290
M06.46 Inflammatory polyarthropathy (Lower leg)
0.000 0.710 0.290
M06.45 Inflammatory polyarthropathy (Pelvic region and thigh)
0.000 0.710 0.290
M06.44 Inflammatory polyarthropathy (Hand)
0.000 0.710 0.290
M06.43 Inflammatory polyarthropathy (Forearm)
0.000 0.710 0.290
M06.42 Inflammatory polyarthropathy (Upper arm)
0.000 0.710 0.290
M06.41 Inflammatory polyarthropathy (Shoulder region)
0.000 0.710 0.290
E50.9 Vitamin A deficiency, unspecified
0.000 0.719 0.281
E50.8 Other manifestations of vitamin A deficiency
0.000 0.719 0.281
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.719 0.281
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.719 0.281
E50.5 Vitamin A deficiency with night blindness
0.000 0.719 0.281
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.719 0.281
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.719 0.281
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.719 0.281
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.719 0.281
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.719 0.281
E51.9 Thiamine deficiency, unspecified
0.000 0.719 0.281
E51.8 Other manifestations of thiamine deficiency
0.000 0.719 0.281
E51.2 Wernicke's encephalopathy
0.000 0.719 0.281
E51.1 Beriberi
0.000 0.719 0.281
E56.9 Vitamin deficiency, unspecified
0.000 0.719 0.281
E56.8 Deficiency of other vitamins
0.000 0.719 0.281
E56.1 Deficiency of vitamin K
0.000 0.719 0.281
E56.0 Deficiency of vitamin E
0.000 0.719 0.281
E63.9 Nutritional deficiency, unspecified
0.000 0.719 0.281
E63.8 Other specified nutritional deficiencies
0.000 0.719 0.281
E63.1 Imbalance of constituents of food intake
0.000 0.719 0.281
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.719 0.281
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.719 0.281
E64.8 Sequelae of other nutritional deficiencies
0.000 0.719 0.281
E64.3 Sequelae of rickets
0.000 0.719 0.281
E64.2 Sequelae of vitamin C deficiency
0.000 0.719 0.281
E64.1 Sequelae of vitamin A deficiency
0.000 0.719 0.281
E64.0 Sequelae of protein-energy malnutrition
0.000 0.719 0.281
E55 Vitamin D deficiency
0.000 0.720 0.280
M06.40 Inflammatory polyarthropathy (Multiple sites)
0.000 0.724 0.276
M06.49 Inflammatory polyarthropathy (Site unspecified)
0.000 0.727 0.273
E27 Other disorders of adrenal gland
0.000 0.727 0.272
E21.0 Primary hyperparathyroidism
0.000 0.733 0.267
E88.9 Metabolic disorder, unspecified
0.000 0.737 0.262
E83.4 Disorders of magnesium metabolism
0.104 0.739 0.157
K90 Intestinal malabsorption
0.000 0.746 0.254
E88.2 Lipomatosis, not elsewhere classified
0.000 0.749 0.251
E88.8 Other specified metabolic disorders
0.001 0.765 0.235
E67.8 Other specified hyperalimentation
0.000 0.766 0.234
E67.3 Hypervitaminosis D
0.000 0.766 0.234

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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