TreeWAS – Variant ID: rs2523536

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	No effect posterior probability	Protective posterior probability
E03.9 Hypothyroidism, unspecified	0.000	1.000
Chapter IV Endocrine, nutritional and metabolic diseases	0.000	1.000
E00-E07 Disorders of thyroid gland	0.000	1.000
Chapter XII Diseases of the skin and subcutaneous tissue	0.000	1.000
E03 Other hypothyroidism	0.000	1.000
# Top node	0.000	1.000
L40-L45 Papulosquamous disorders	0.003	0.997
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	0.003	0.997
L40 Psoriasis	0.004	0.996
E65-E68 Obesity and other hyperalimentation	0.006	0.994
L55-L59 Radiation-related disorders of the skin and subcutaneous tissue	0.008	0.992
E66 Obesity	0.010	0.990
E66.8 Other obesity	0.012	0.988
D50-D53 Nutritional anaemias	0.012	0.988
L57 Skin changes due to chronic exposure to nonionising radiation	0.014	0.986
L40.9 Psoriasis, unspecified	0.014	0.986
D50 Iron deficiency anaemia	0.015	0.985
L40.5 Arthropathic psoriasis	0.015	0.985
Chapter I Certain infectious and parasitic diseases	0.017	0.983
D50.9 Iron deficiency anaemia, unspecified	0.018	0.982
L00-L08 Infections of the skin and subcutaneous tissue	0.018	0.982
M06.9 Rheumatoid arthritis, unspecified	0.019	0.981
M06 Other rheumatoid arthritis	0.020	0.980
M05-M14 Inflammatory polyarthropathies	0.021	0.979
Chapter XIII Diseases of the musculoskeletal system and connective tissue	0.024	0.976
L57.0 Actinic keratosis	0.024	0.976
B35-B49 Mycoses	0.025	0.975
B37 Candidiasis	0.028	0.972
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)	0.031	0.969
B37.8 Candidiasis of other sites	0.031	0.969
Chapter VIII Diseases of the ear and mastoid process	0.033	0.967
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)	0.035	0.965
L02 Cutaneous abscess, furuncle and carbuncle	0.036	0.964
L02.2 Cutaneous abscess, furuncle and carbuncle of trunk	0.044	0.956
B25-B34 Other viral diseases	0.052	0.948
E70-E90 Metabolic disorders	0.053	0.947
H65-H75 Diseases of middle ear and mastoid	0.054	0.946
L20-L30 Dermatitis and eczema	0.065	0.935
H72 Perforation of tympanic membrane	0.066	0.934
H72.9 Perforation of tympanic membrane, unspecified	0.075	0.925
B34 Viral infection of unspecified site	0.081	0.919
Chapter V Mental and behavioural disorders	0.082	0.918
B37.0 Candidal stomatitis	0.084	0.916
E06 Thyroiditis	0.094	0.906
E05 Thyrotoxicosis [hyperthyroidism]	0.097	0.903
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions	0.099	0.901
B34.9 Viral infection, unspecified	0.112	0.888
M07 Psoriatic and enteropathic arthropathies	0.114	0.886
M45-M49 Spondylopathies	0.117	0.883
L57.8 Other skin changes due to chronic exposure to nonionising radiation	0.122	0.878
H65 Nonsuppurative otitis media	0.129	0.871
M45 Ankylosing spondylitis	0.129	0.871
M05 Seropositive rheumatoid arthritis	0.130	0.870
M95-M99 Other disorders of the musculoskeletal system and connective tissue	0.130	0.869
L08 Other local infections of skin and subcutaneous tissue	0.134	0.866
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified	0.136	0.864
D80-D89 Certain disorders involving the immune mechanism	0.137	0.863
M45.X9 Ankylosing spondylitis (Site unspecified)	0.145	0.855
D50.0 Iron deficiency anaemia secondary to blood loss (chronic)	0.157	0.843
M06.0 Seronegative rheumatoid arthritis	0.165	0.835
L29 Pruritus	0.169	0.831
D68 Other coagulation defects	0.169	0.831
E06.3 Autoimmune thyroiditis	0.172	0.828
M95 Other acquired deformities of musculoskeletal system and connective tissue	0.173	0.827
H80-H83 Diseases of inner ear	0.175	0.825
M06.97 Rheumatoid arthritis, unspecified (Ankle and foot)	0.176	0.824
M35 Other systemic involvement of connective tissue	0.176	0.824
M20-M25 Other joint disorders	0.179	0.821
M35.3 Polymyalgia rheumatica	0.179	0.821
M07.3 Other psoriatic arthropathies	0.180	0.820
B20-B24 Human immunodeficiency virus [HIV] disease	0.183	0.817
E89.0 Postprocedural hypothyroidism	0.185	0.815
D86 Sarcoidosis	0.189	0.811
E10-E14 Diabetes mellitus	0.190	0.810
M06.91 Rheumatoid arthritis, unspecified (Shoulder region)	0.195	0.805
E20-E35 Disorders of other endocrine glands	0.199	0.801
E05.0 Thyrotoxicosis with diffuse goitre	0.199	0.801
L02.4 Cutaneous abscess, furuncle and carbuncle of limb	0.200	0.800
L30 Other dermatitis	0.202	0.798
M95.0 Acquired deformity of nose	0.204	0.796
E87 Other disorders of fluid, electrolyte and acid-base balance	0.208	0.792
M05.9 Seropositive rheumatoid arthritis, unspecified	0.209	0.791
B35 Dermatophytosis	0.210	0.790
H72.0 Central perforation of tympanic membrane	0.213	0.787
L29.0 Pruritus ani	0.215	0.785
E86 Volume depletion	0.216	0.784
M06.93 Rheumatoid arthritis, unspecified (Forearm)	0.219	0.781
L08.9 Local infection of skin and subcutaneous tissue, unspecified	0.220	0.780
F60-F69 Disorders of adult personality and behaviour	0.224	0.776
B99-B99 Other infectious diseases	0.225	0.775
H65.9 Nonsuppurative otitis media, unspecified	0.228	0.772
F20-F29 Schizophrenia, schizotypal and delusional disorders	0.228	0.772
E10 Insulin-dependent diabetes mellitus	0.230	0.770
E27 Other disorders of adrenal gland	0.235	0.765
M06.96 Rheumatoid arthritis, unspecified (Lower leg)	0.239	0.761
D55-D59 Haemolytic anaemias	0.240	0.760
F30-F39 Mood [affective] disorders	0.241	0.759
B34.8 Other viral infections of unspecified site	0.241	0.759
E66.0 Obesity due to excess calories	0.247	0.753
A50-A64 Infections with a predominantly sexual mode of transmission	0.249	0.751
L27 Dermatitis due to substances taken internally	0.249	0.750
D86.9 Sarcoidosis, unspecified	0.250	0.750
L05 Pilonidal cyst	0.250	0.750
E73 Lactose intolerance	0.254	0.746
M05.90 Seropositive rheumatoid arthritis, unspecified (Multiple sites)	0.255	0.745
E05.9 Thyrotoxicosis, unspecified	0.256	0.744
M07.30 Other psoriatic arthropathies (Multiple sites)	0.256	0.744
F00-F09 Organic, including symptomatic, mental disorders	0.257	0.743
L56 Other acute skin changes due to ultraviolet radiation	0.259	0.741
M00-M03 Infectious arthropathies	0.259	0.741
E27.1 Primary adrenocortical insufficiency	0.261	0.739
Chapter XXII Codes for special purposes	0.262	0.738
M45.X0 Ankylosing spondylitis (Multiple sites in spine)	0.264	0.736
E88 Other metabolic disorders	0.266	0.734
F40-F48 Neurotic, stress-related and somatoform disorders	0.267	0.733
H80 Otosclerosis	0.269	0.731
F80-F89 Disorders of psychological development	0.270	0.730
M06.00 Seronegative rheumatoid arthritis (Multiple sites)	0.273	0.727
D68.5 Primary Thrombophilia	0.281	0.719
M35.0 Sicca syndrome [Sjogren]	0.281	0.719
E80 Disorders of porphyrin and bilirubin metabolism	0.281	0.718
E01 Iodine-deficiency-related thyroid disorders and allied conditions	0.283	0.717
E00 Congenital iodine-deficiency syndrome	0.283	0.717
E02 Subclinical iodine-deficiency hypothyroidism	0.283	0.717
E03.5 Myxoedema coma	0.283	0.717
E03.4 Atrophy of thyroid (acquired)	0.283	0.717
E03.3 Postinfectious hypothyroidism	0.283	0.717
E03.1 Congenital hypothyroidism without goitre	0.283	0.717
E03.0 Congenital hypothyroidism with diffuse goitre	0.283	0.717
Chapter XVI Certain conditions originating in the perinatal period	0.283	0.717
L02.3 Cutaneous abscess, furuncle and carbuncle of buttock	0.284	0.716
E65 Localised adiposity	0.284	0.716
B25 Cytomegaloviral disease	0.285	0.715
L44 Other papulosquamous disorders	0.285	0.715
L41 Parapsoriasis	0.285	0.715
L45 Papulosquamous disorders in diseases classified elsewhere	0.285	0.715
L40.8 Other psoriasis	0.286	0.714
L40.4 Guttate psoriasis	0.286	0.714
L40.3 Pustulosis palmaris et plantaris	0.286	0.714
L40.2 Acrodermatitis continua	0.286	0.714
L40.1 Generalised pustular psoriasis	0.286	0.714
E87.1 Hypo-osmolality and hyponatraemia	0.286	0.714
E05.2 Thyrotoxicosis with toxic multinodular goitre	0.287	0.713
E67 Other hyperalimentation	0.287	0.713
E68 Sequelae of hyperalimentation	0.287	0.713
L59 Other disorders of skin and subcutaneous tissue related to radiation	0.289	0.711
L58 Radiodermatitis	0.289	0.711
L55 Sunburn	0.289	0.711
E66.1 Drug-induced obesity	0.290	0.709
L57.9 Skin changes due to chronic exposure to nonionising radiation, unspecified	0.293	0.707
L57.5 Actinic granuloma	0.293	0.707
L57.3 Poikiloderma of Civatte	0.293	0.707
L57.2 Cutis rhomboidalis nuchae	0.293	0.707
L57.1 Actinic reticuloid	0.293	0.707
D50.1 Sideropenic dysphagia	0.294	0.706
A92-A99 Arthropod-borne viral fevers and viral haemorrhagic fevers	0.295	0.705
A75-A79 Rickettsioses	0.295	0.705
A70-A74 Other diseases caused by chlamydiae	0.295	0.705
A65-A69 Other spirochaetal diseases	0.295	0.705
A20-A28 Certain zoonotic bacterial diseases	0.295	0.705
D86.0 Sarcoidosis of lung	0.295	0.705
H73 Other disorders of tympanic membrane	0.295	0.705
L04 Acute lymphadenitis	0.296	0.704
L01 Impetigo	0.296	0.704
L00 Staphylococcal scalded skin syndrome	0.296	0.704
M06.98 Rheumatoid arthritis, unspecified (Other)	0.296	0.704
M06.8 Other specified rheumatoid arthritis	0.297	0.703
M06.2 Rheumatoid bursitis	0.297	0.703
M06.1 Adult-onset Still's disease	0.297	0.703
M34 Systemic sclerosis	0.298	0.702
M14 Arthropathies in other diseases classified elsewhere	0.298	0.702
M12 Other specific arthropathies	0.298	0.702
M09 Juvenile arthritis in diseases classified elsewhere	0.298	0.702
M08 Juvenile arthritis	0.298	0.702
B48 Other mycoses, not elsewhere classified	0.301	0.699
B47 Mycetoma	0.301	0.699
B46 Zygomycosis	0.301	0.699
B45 Cryptococcosis	0.301	0.699
B43 Chromomycosis and phaeomycotic abscess	0.301	0.699
B42 Sporotrichosis	0.301	0.699
B41 Paracoccidioidomycosis	0.301	0.699
B40 Blastomycosis	0.301	0.699
B39 Histoplasmosis	0.301	0.699
B38 Coccidioidomycosis	0.301	0.699
B36 Other superficial mycoses	0.301	0.699
B24 Unspecified human immunodeficiency virus [HIV] disease	0.302	0.698
D68.9 Coagulation defect, unspecified	0.303	0.697
B37.7 Candidal septicaemia	0.303	0.697
B37.6 Candidal endocarditis	0.303	0.697
B37.5 Candidal meningitis	0.303	0.697
E50-E64 Other nutritional deficiencies	0.307	0.693
L02.8 Cutaneous abscess, furuncle and carbuncle of other sites	0.308	0.691
H65.4 Other chronic nonsuppurative otitis media	0.309	0.691
E74 Other disorders of carbohydrate metabolism	0.313	0.687
A15-A19 Tuberculosis	0.314	0.686
E06.9 Thyroiditis, unspecified	0.314	0.686
H60-H62 Diseases of external ear	0.315	0.685
H65.2 Chronic serous otitis media	0.317	0.683
F31 Bipolar affective disorder	0.320	0.680
B33 Other viral diseases, not elsewhere classified	0.320	0.680
B30 Viral conjunctivitis	0.320	0.680
B27 Infectious mononucleosis	0.320	0.680
B26 Mumps	0.320	0.680
E84 Cystic fibrosis	0.321	0.679
E79 Disorders of purine and pyrimidine metabolism	0.321	0.679
E77 Disorders of glycoprotein metabolism	0.321	0.679
E76 Disorders of glycosaminoglycan metabolism	0.321	0.679
E75 Disorders of sphingolipid metabolism and other lipid storage disorders	0.321	0.679
E72 Other disorders of amino-acid metabolism	0.321	0.679
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism	0.321	0.679
E70 Disorders of aromatic amino-acid metabolism	0.321	0.679
E90 Nutritional and metabolic disorders in diseases classified elsewhere	0.321	0.679
H75 Other disorders of middle ear and mastoid in diseases classified elsewhere	0.321	0.679
H68 Eustachian salpingitis and obstruction	0.321	0.679
H67 Otitis media in diseases classified elsewhere	0.321	0.679
L57.4 Cutis laxa senilis	0.322	0.678
F60 Specific personality disorders	0.322	0.677
L10-L14 Bullous disorders	0.323	0.677
B50-B64 Protozoal diseases	0.324	0.676
M07.39 Other psoriatic arthropathies (Site unspecified)	0.324	0.676
M35.7 Hypermobility syndrome	0.327	0.673
E10.3 With ophthalmic complications	0.327	0.673
L28 Lichen simplex chronicus and prurigo	0.327	0.673
H70 Mastoiditis and related conditions	0.327	0.673
E87.2 Acidosis	0.328	0.672
M11 Other crystal arthropathies	0.328	0.672
B15-B19 Viral hepatitis	0.328	0.672
L02.9 Cutaneous abscess, furuncle and carbuncle, unspecified	0.329	0.671
Chapter XVIII Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	0.329	0.671
L24 Irritant contact dermatitis	0.330	0.670
L21 Seborrhoeic dermatitis	0.330	0.670
L26 Exfoliative dermatitis	0.330	0.670
L22 Diaper [napkin] dermatitis	0.330	0.670
M06.09 Seronegative rheumatoid arthritis (Site unspecified)	0.330	0.670
H72.1 Attic perforation of tympanic membrane	0.331	0.669
E03.2 Hypothyroidism due to medicaments and other exogenous substances	0.332	0.668
E40-E46 Malnutrition	0.333	0.667
M46 Other inflammatory spondylopathies	0.335	0.665
H80.9 Otosclerosis, unspecified	0.337	0.663
D68.3 Haemorrhagic disorder due to circulating anticoagulants	0.338	0.662
L20 Atopic dermatitis	0.339	0.661
B34.3 Parvovirus infection, unspecified	0.341	0.659
B34.2 Coronavirus infection, unspecified	0.341	0.659
B34.1 Enterovirus infection, unspecified	0.341	0.659
B34.0 Adenovirus infection, unspecified	0.341	0.659
F90-F98 Behavioural and emotional disorders with onset usually occurring in childhood and adolescence	0.342	0.658
E03.8 Other specified hypothyroidism	0.342	0.658
H83 Other diseases of inner ear	0.342	0.658
E66.2 Extreme obesity with alveolar hypoventilation	0.344	0.656
D69 Purpura and other haemorrhagic conditions	0.345	0.655
L30.8 Other specified dermatitis	0.349	0.651
R21 Rash and other nonspecific skin eruption	0.349	0.651
L25 Unspecified contact dermatitis	0.349	0.651
F42 Obsessive-compulsive disorder	0.350	0.650
E06.5 Other chronic thyroiditis	0.350	0.650
E06.4 Drug-induced thyroiditis	0.350	0.650
E06.2 Chronic thyroiditis with transient thyrotoxicosis	0.350	0.650
E06.1 Subacute thyroiditis	0.350	0.650
E06.0 Acute thyroiditis	0.350	0.650
B37.9 Candidiasis, unspecified	0.351	0.649
B35.1 Tinea unguium	0.351	0.649
B90-B94 Sequelae of infectious and parasitic diseases	0.352	0.648
E10.9 Without complications	0.353	0.647
R20-R23 Symptoms and signs involving the skin and subcutaneous tissue	0.353	0.647
E05.5 Thyroid crisis or storm	0.353	0.647
E05.4 Thyrotoxicosis factitia	0.353	0.647
E05.3 Thyrotoxicosis from ectopic thyroid tissue	0.353	0.647
E05.1 Thyrotoxicosis with toxic single thyroid nodule	0.353	0.647
D52 Folate deficiency anaemia	0.353	0.647
D66 Hereditary factor VIII deficiency	0.354	0.646
D67 Hereditary factor IX deficiency	0.354	0.646
D65 Disseminated intravascular coagulation [defibrination syndrome]	0.354	0.646
L30.9 Dermatitis, unspecified	0.354	0.646
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)	0.356	0.644
B37.4 Candidiasis of other urogenital sites	0.357	0.643
L05.0 Pilonidal cyst with abscess	0.358	0.642
M06.4 Inflammatory polyarthropathy	0.359	0.641
B65-B83 Helminthiases	0.360	0.639
B85-B89 Pediculosis, acariasis and other infestations	0.362	0.638
F70-F79 Mental retardation	0.362	0.638
B37.1 Pulmonary candidiasis	0.362	0.637
B34.4 Papovirus infection, unspecified	0.363	0.637
D68.2 Hereditary deficiency of other clotting factors	0.364	0.636
D51 Vitamin B12 deficiency anaemia	0.364	0.635
M07.6 Other enteropathic arthropathies	0.364	0.635
M07.5 Arthropathy in ulcerative colitis	0.364	0.635
M07.4 Arthropathy in Crohn's disease [regional enteritis]	0.364	0.635
M07.2 Psoriatic spondylitis	0.364	0.635
M07.1 Arthritis mutilans	0.364	0.635
M07.0 Distal interphalangeal psoriatic arthropathy	0.364	0.635
B37.2 Candidiasis of skin and nail	0.365	0.634
L23 Allergic contact dermatitis	0.366	0.634
L27.0 Generalised skin eruption due to drugs and medicaments	0.367	0.633
D50.8 Other iron deficiency anaemias	0.367	0.633
E22 Hyperfunction of pituitary gland	0.368	0.632
F22 Persistent delusional disorders	0.368	0.632
D68.0 Von Willebrand's disease	0.368	0.632
E10.1 With ketoacidosis	0.368	0.631
R25-R29 Symptoms and signs involving the nervous and musculoskeletal systems	0.369	0.631
E85 Amyloidosis	0.370	0.630
L08.8 Other specified local infections of skin and subcutaneous tissue	0.370	0.630
M06.92 Rheumatoid arthritis, unspecified (Upper arm)	0.370	0.630
M06.3 Rheumatoid nodule	0.371	0.629
H65.3 Chronic mucoid otitis media	0.374	0.626
B99 Other and unspecified infectious diseases	0.374	0.625
H65.1 Other acute nonsuppurative otitis media	0.376	0.624
H65.0 Acute serous otitis media	0.376	0.624
M45.X8 Ankylosing spondylitis (Sacral and sacrococcygeal region)	0.376	0.624
M45.X7 Ankylosing spondylitis (Lumbosacral region)	0.376	0.624
M45.X6 Ankylosing spondylitis (Lumbar region)	0.376	0.624
M45.X5 Ankylosing spondylitis (Thoracolumbar region)	0.376	0.624
M45.X4 Ankylosing spondylitis (Thoracic region)	0.376	0.624
M45.X3 Ankylosing spondylitis (Cervicothoracic region)	0.376	0.624
M45.X2 Ankylosing spondylitis (Cervical region)	0.376	0.624
M45.X1 Ankylosing spondylitis (Occipito-atlanto-axial region)	0.376	0.624
E07 Other disorders of thyroid	0.376	0.624
M05.8 Other seropositive rheumatoid arthritis	0.376	0.623
M05.3 Rheumatoid arthritis with involvement of other organs and systems	0.376	0.623
M05.2 Rheumatoid vasculitis	0.376	0.623
M05.1 Rheumatoid lung disease	0.376	0.623
M05.0 Felty's syndrome	0.376	0.623
M99 Biomechanical lesions, not elsewhere classified	0.376	0.623
M60-M63 Disorders of muscles	0.377	0.623
F20 Schizophrenia	0.377	0.623
E21 Hyperparathyroidism and other disorders of parathyroid gland	0.378	0.622
L08.1 Erythrasma	0.379	0.621
L08.0 Pyoderma	0.379	0.621
F43 Reaction to severe stress, and adjustment disorders	0.379	0.621
E89.9 Postprocedural endocrine and metabolic disorder, unspecified	0.380	0.619
E89.8 Other postprocedural endocrine and metabolic disorders	0.380	0.619
E89.6 Postprocedural adrenocortical(-medullary) hypofunction	0.380	0.619
E89.5 Postprocedural testicular hypofunction	0.380	0.619
E89.4 Postprocedural ovarian failure	0.380	0.619
E89.1 Postprocedural hypoinsulinaemia	0.380	0.619
D84 Other immunodeficiencies	0.381	0.619
D83 Common variable immunodeficiency	0.381	0.619
D82 Immunodeficiency associated with other major defects	0.381	0.619
D81 Combined immunodeficiencies	0.381	0.619
M91-M94 Chondropathies	0.381	0.618
R26 Abnormalities of gait and mobility	0.382	0.618
D59 Acquired haemolytic anaemia	0.382	0.618
F81 Specific developmental disorders of scholastic skills	0.383	0.617
M49 Spondylopathies in diseases classified elsewhere	0.383	0.617
F31.1 Bipolar affective disorder, current episode manic without psychotic symptoms	0.384	0.616
L29.8 Other pruritus	0.389	0.611
Chapter IX Diseases of the circulatory system	0.391	0.609
H69 Other disorders of Eustachian tube	0.393	0.607
E89.3 Postprocedural hypopituitarism	0.393	0.607
M22 Disorders of patella	0.394	0.606
E88.0 Disorders of plasma-protein metabolism, not elsewhere classified	0.394	0.606
A63 Other predominantly sexually transmitted diseases, not elsewhere classified	0.395	0.605
D70-D77 Other diseases of blood and blood-forming organs	0.396	0.604
E14 Unspecified diabetes mellitus	0.397	0.603
F30 Manic episode	0.398	0.602
E73.9 Lactose intolerance, unspecified	0.398	0.602
E10.2 With renal complications	0.400	0.600
R26.8 Other and unspecified abnormalities of gait and mobility	0.400	0.600
L29.9 Pruritus, unspecified	0.401	0.599
D53 Other nutritional anaemias	0.401	0.599
E27.4 Other and unspecified adrenocortical insufficiency	0.401	0.599
D60-D64 Aplastic and other anaemias	0.401	0.599
M06.08 Seronegative rheumatoid arthritis (Other)	0.401	0.599
M06.07 Seronegative rheumatoid arthritis (Ankle and foot)	0.401	0.599
M06.05 Seronegative rheumatoid arthritis (Pelvic region and thigh)	0.401	0.599
M06.04 Seronegative rheumatoid arthritis (Hand)	0.401	0.599
M06.03 Seronegative rheumatoid arthritis (Forearm)	0.401	0.599
M06.02 Seronegative rheumatoid arthritis (Upper arm)	0.401	0.599
M06.01 Seronegative rheumatoid arthritis (Shoulder region)	0.401	0.599
E10.5 With peripheral circulatory complications	0.403	0.597
M30 Polyarteritis nodosa and related conditions	0.404	0.596
L29.3 Anogenital pruritus, unspecified	0.404	0.596
L29.1 Pruritus scroti	0.404	0.596
D68.4 Acquired coagulation factor deficiency	0.404	0.595
D68.1 Hereditary factor XI deficiency	0.404	0.595
F99-F99 Unspecified mental disorder	0.405	0.595
F25 Schizoaffective disorders	0.405	0.595
E87.7 Fluid overload	0.406	0.594
M34.9 Systemic sclerosis, unspecified	0.407	0.593
M95.9 Acquired deformity of musculoskeletal system, unspecified	0.407	0.593
M95.8 Other specified acquired deformities of musculoskeletal system	0.407	0.593
M95.5 Acquired deformity of pelvis	0.407	0.593
M95.4 Acquired deformity of chest and rib	0.407	0.593
M95.3 Acquired deformity of neck	0.407	0.593
M95.2 Other acquired deformity of head	0.407	0.593
M95.1 Cauliflower ear	0.407	0.593
H82 Vertiginous syndromes in diseases classified elsewhere	0.408	0.592
M35.9 Systemic involvement of connective tissue, unspecified	0.409	0.591
M35.8 Other specified systemic involvement of connective tissue	0.409	0.591
M35.6 Relapsing panniculitis [Weber-Christian]	0.409	0.591
M35.5 Multifocal fibrosclerosis	0.409	0.591
M35.4 Diffuse (eosinophilic) fasciitis	0.409	0.591
M35.2 Behcet's disease	0.409	0.591
M35.1 Other overlap syndromes	0.409	0.591
F42.9 Obsessive-compulsive disorder, unspecified	0.409	0.591
F05 Delirium, not induced by alcohol and other psychoactive substances	0.409	0.591
M36 Systemic disorders of connective tissue in diseases classified elsewhere	0.411	0.589
M32 Systemic lupus erythematosus	0.411	0.589
L42 Pityriasis rosea	0.411	0.588
M07.38 Other psoriatic arthropathies (Other)	0.412	0.588
M07.37 Other psoriatic arthropathies (Ankle and foot)	0.412	0.588
M07.36 Other psoriatic arthropathies (Lower leg)	0.412	0.588
M07.35 Other psoriatic arthropathies (Pelvic region and thigh)	0.412	0.588
M07.34 Other psoriatic arthropathies (Hand)	0.412	0.588
M07.33 Other psoriatic arthropathies (Forearm)	0.412	0.588
M07.32 Other psoriatic arthropathies (Upper arm)	0.412	0.588
M07.31 Other psoriatic arthropathies (Shoulder region)	0.412	0.588
L02.0 Cutaneous abscess, furuncle and carbuncle of face	0.414	0.586
B23 Human immunodeficiency virus [HIV] disease resulting in other conditions	0.414	0.586
B22 Human immunodeficiency virus [HIV] disease resulting in other specified diseases	0.414	0.586
B21 Human immunodeficiency virus [HIV] disease resulting in malignant neoplasms	0.414	0.586
B20 Human immunodeficiency virus [HIV] disease resulting in infectious and parasitic diseases	0.414	0.586
F23 Acute and transient psychotic disorders	0.417	0.583
U00-U49 Provisional assignment of new diseases of uncertain etiology or emergency use	0.417	0.583
R47-R49 Symptoms and signs involving speech and voice	0.417	0.583
E89.2 Postprocedural hypoparathyroidism	0.418	0.582
M05.99 Seropositive rheumatoid arthritis, unspecified (Site unspecified)	0.418	0.582
D86.3 Sarcoidosis of skin	0.419	0.581
D86.2 Sarcoidosis of lung with sarcoidosis of lymph nodes	0.419	0.581
D86.1 Sarcoidosis of lymph nodes	0.419	0.581
E12 Malnutrition-related diabetes mellitus	0.419	0.581
H72.2 Other marginal perforations of tympanic membrane	0.419	0.581
B35.3 Tinea pedis	0.421	0.579
M10 Gout	0.424	0.576
A30-A49 Other bacterial diseases	0.425	0.575
E35 Disorders of endocrine glands in diseases classified elsewhere	0.426	0.574
E32 Diseases of thymus	0.426	0.574
E31 Polyglandular dysfunction	0.426	0.574
E30 Disorders of puberty, not elsewhere classified	0.426	0.574
E25 Adrenogenital disorders	0.426	0.574
E20 Hypoparathyroidism	0.426	0.574
E10.4 With neurological complications	0.427	0.573
M00 Pyogenic arthritis	0.428	0.572
L30.5 Pityriasis alba	0.428	0.572
L30.4 Erythema intertrigo	0.428	0.572
L30.3 Infective dermatitis	0.428	0.572
L30.2 Cutaneous autosensitisation	0.428	0.572
L30.1 Dyshidrosis [pompholyx]	0.428	0.572
L30.0 Nummular dermatitis	0.428	0.572
L43 Lichen planus	0.430	0.570
H72.8 Other perforations of tympanic membrane	0.431	0.569
H66 Suppurative and unspecified otitis media	0.431	0.569
E87.4 Mixed disorder of acid-base balance	0.432	0.568
M05.98 Seropositive rheumatoid arthritis, unspecified (Other)	0.433	0.567
M05.96 Seropositive rheumatoid arthritis, unspecified (Lower leg)	0.433	0.567
M05.95 Seropositive rheumatoid arthritis, unspecified (Pelvic region and thigh)	0.433	0.567
M05.94 Seropositive rheumatoid arthritis, unspecified (Hand)	0.433	0.567
M05.93 Seropositive rheumatoid arthritis, unspecified (Forearm)	0.433	0.567
M05.92 Seropositive rheumatoid arthritis, unspecified (Upper arm)	0.433	0.567
M05.91 Seropositive rheumatoid arthritis, unspecified (Shoulder region)	0.433	0.567
F06 Other mental disorders due to brain damage and dysfunction and to physical disease	0.434	0.566
L40.0 Psoriasis vulgaris	0.434	0.566
B35.9 Dermatophytosis, unspecified	0.434	0.566
B35.8 Other dermatophytoses	0.434	0.566
B35.6 Tinea cruris	0.434	0.566
B35.5 Tinea imbricata	0.434	0.566
B35.4 Tinea corporis	0.434	0.566
B35.2 Tinea manuum	0.434	0.566
B35.0 Tinea barbae and tinea capitis	0.434	0.566
M46.9 Inflammatory spondylopathy, unspecified	0.435	0.565
F60.3 Emotionally unstable personality disorder	0.436	0.564
F40 Phobic anxiety disorders	0.439	0.561
D68.6 Other Thrombophilia	0.439	0.561
L56.8 Other specified acute skin changes due to ultraviolet radiation	0.439	0.561
I60-I69 Cerebrovascular diseases	0.440	0.560
F00 Dementia in Alzheimer's disease	0.441	0.559
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion	0.442	0.558
F60.9 Personality disorder, unspecified	0.442	0.558
E83 Disorders of mineral metabolism	0.442	0.558
D69.3 Idiopathic thrombocytopenic purpura	0.443	0.557
A80-A89 Viral infections of the central nervous system	0.443	0.556
F68 Other disorders of adult personality and behaviour	0.444	0.556
F66 Psychological and behavioural disorders associated with sexual development and orientation	0.444	0.556
F65 Disorders of sexual preference	0.444	0.556
F63 Habit and impulse disorders	0.444	0.556
F62 Enduring personality changes, not attributable to brain damage and disease	0.444	0.556
F69 Unspecified disorder of adult personality and behaviour	0.444	0.556
F61 Mixed and other personality disorders	0.444	0.556
E80.4 Gilbert's syndrome	0.445	0.555
F28 Other nonorganic psychotic disorders	0.446	0.554
F24 Induced delusional disorder	0.446	0.554
F21 Schizotypal disorder	0.446	0.554
E26 Hyperaldosteronism	0.446	0.553
E10.7 With multiple complications	0.448	0.552
E10.0 With coma	0.448	0.552
L50-L54 Urticaria and erythema	0.448	0.552
B49 Unspecified mycosis	0.449	0.550
R90-R94 Abnormal findings on diagnostic imaging and in function studies, without diagnosis	0.451	0.549
E27.5 Adrenomedullary hyperfunction	0.451	0.548
E27.3 Drug-induced adrenocortical insufficiency	0.451	0.548
E27.2 Addisonian crisis	0.451	0.548
E27.0 Other adrenocortical overactivity	0.451	0.548
B25.9 Cytomegaloviral disease, unspecified	0.452	0.548
M33 Dermatopolymyositis	0.452	0.548
D51.9 Vitamin B12 deficiency anaemia, unspecified	0.452	0.547
F64 Gender identity disorders	0.452	0.547
M34.1 CR(E)ST syndrome	0.453	0.547
D57 Sickle-cell disorders	0.455	0.545
D56 Thalassaemia	0.455	0.545
D55 Anaemia due to enzyme disorders	0.455	0.545
F38 Other mood [affective] disorders	0.455	0.544

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations