TreeWAS – Variant ID: rs2523545

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	No effect posterior probability	Protective posterior probability
E10.9 Without complications	0.000	1.000
E10.3 With ophthalmic complications	0.000	1.000
K90.0 Coeliac disease	0.000	1.000
L40.9 Psoriasis, unspecified	0.000	1.000
L40.5 Arthropathic psoriasis	0.000	1.000
M06.9 Rheumatoid arthritis, unspecified	0.000	1.000
M45.X9 Ankylosing spondylitis (Site unspecified)	0.000	1.000
E05 Thyrotoxicosis [hyperthyroidism]	0.000	1.000
E10 Insulin-dependent diabetes mellitus	0.000	1.000
E10-E14 Diabetes mellitus	0.000	1.000
Chapter IV Endocrine, nutritional and metabolic diseases	0.000	1.000
L40 Psoriasis	0.000	1.000
M45 Ankylosing spondylitis	0.000	1.000
M05-M14 Inflammatory polyarthropathies	0.000	1.000
E11 Non-insulin-dependent diabetes mellitus	0.000	1.000
M07.3 Other psoriatic arthropathies	0.000	1.000
E00-E07 Disorders of thyroid gland	0.000	1.000
M06 Other rheumatoid arthritis	0.000	1.000
E05.0 Thyrotoxicosis with diffuse goitre	0.000	1.000
E05.9 Thyrotoxicosis, unspecified	0.000	1.000
M07 Psoriatic and enteropathic arthropathies	0.000	1.000
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)	0.001	0.999
Chapter XIII Diseases of the musculoskeletal system and connective tissue	0.001	0.999
E14 Unspecified diabetes mellitus	0.001	0.999
M20-M25 Other joint disorders	0.002	0.998
M07.30 Other psoriatic arthropathies (Multiple sites)	0.002	0.998
M45-M49 Spondylopathies	0.003	0.997
E11.9 Without complications	0.003	0.997
E10.1 With ketoacidosis	0.003	0.997
M35 Other systemic involvement of connective tissue	0.005	0.995
M45.X0 Ankylosing spondylitis (Multiple sites in spine)	0.008	0.992
M24 Other specific joint derangements	0.011	0.989
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)	0.012	0.988
E10.4 With neurological complications	0.020	0.980
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion	0.022	0.978
E10.2 With renal complications	0.024	0.976
E14.9 Without complications	0.029	0.971
M07.39 Other psoriatic arthropathies (Site unspecified)	0.038	0.962
M35.0 Sicca syndrome [Sjogren]	0.038	0.962
E16 Other disorders of pancreatic internal secretion	0.038	0.962
E70-E90 Metabolic disorders	0.038	0.962
E78 Disorders of lipoprotein metabolism and other lipidaemias	0.038	0.962
E65-E68 Obesity and other hyperalimentation	0.039	0.961
M07.36 Other psoriatic arthropathies (Lower leg)	0.040	0.960
E78.0 Pure hypercholesterolaemia	0.041	0.959
E06 Thyroiditis	0.042	0.958
M35.3 Polymyalgia rheumatica	0.046	0.954
M24.0 Loose body in joint	0.051	0.949
E16.2 Hypoglycaemia, unspecified	0.052	0.948
M06.91 Rheumatoid arthritis, unspecified (Shoulder region)	0.072	0.928
E14.3 With ophthalmic complications	0.072	0.928
E14.8 With unspecified complications	0.074	0.926
M24.2 Disorder of ligament	0.074	0.926
M06.96 Rheumatoid arthritis, unspecified (Lower leg)	0.076	0.924
E66 Obesity	0.077	0.923
E11.3 With ophthalmic complications	0.078	0.922
E20-E35 Disorders of other endocrine glands	0.084	0.916
M34 Systemic sclerosis	0.092	0.908
E11.1 With ketoacidosis	0.096	0.904
E66.8 Other obesity	0.097	0.903
E78.2 Mixed hyperlipidaemia	0.097	0.903
E10.5 With peripheral circulatory complications	0.101	0.899
E10.8 With unspecified complications	0.110	0.890
M25 Other joint disorders, not elsewhere classified	0.118	0.882
E11.5 With peripheral circulatory complications	0.126	0.874
E06.3 Autoimmune thyroiditis	0.131	0.869
E21 Hyperparathyroidism and other disorders of parathyroid gland	0.132	0.868
E06.9 Thyroiditis, unspecified	0.142	0.858
M24.27 Disorder of ligament (Ankle and foot)	0.144	0.856
M07.37 Other psoriatic arthropathies (Ankle and foot)	0.146	0.853
M33 Dermatopolymyositis	0.150	0.850
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified	0.155	0.845
E85 Amyloidosis	0.156	0.844
M24.02 Loose body in joint (Upper arm)	0.156	0.844
M45.X2 Ankylosing spondylitis (Cervical region)	0.162	0.838
L40-L45 Papulosquamous disorders	0.163	0.837
E21.3 Hyperparathyroidism, unspecified	0.164	0.836
M25.9 Joint disorder, unspecified	0.168	0.832
E14.1 With ketoacidosis	0.168	0.832
L40.1 Generalised pustular psoriasis	0.169	0.831
M60-M63 Disorders of muscles	0.170	0.830
M34.1 CR(E)ST syndrome	0.171	0.829
M45.X6 Ankylosing spondylitis (Lumbar region)	0.173	0.827
M06.92 Rheumatoid arthritis, unspecified (Upper arm)	0.175	0.825
M25.5 Pain in joint	0.180	0.820
M91-M94 Chondropathies	0.184	0.816
E11.2 With renal complications	0.187	0.813
M35.1 Other overlap syndromes	0.192	0.808
M35.2 Behcet's disease	0.194	0.806
M06.97 Rheumatoid arthritis, unspecified (Ankle and foot)	0.197	0.803
E50-E64 Other nutritional deficiencies	0.198	0.802
M25.56 Pain in joint (Lower leg)	0.198	0.802
M06.3 Rheumatoid nodule	0.199	0.801
M32 Systemic lupus erythematosus	0.200	0.800
M24.8 Other specific joint derangements, not elsewhere classified	0.201	0.799
M06.93 Rheumatoid arthritis, unspecified (Forearm)	0.203	0.797
M35.7 Hypermobility syndrome	0.204	0.796
M24.1 Other articular cartilage disorders	0.204	0.796
L40.0 Psoriasis vulgaris	0.205	0.795
M05 Seropositive rheumatoid arthritis	0.207	0.793
M06.94 Rheumatoid arthritis, unspecified (Hand)	0.208	0.792
M24.28 Disorder of ligament (Other)	0.209	0.791
L43 Lichen planus	0.211	0.789
E66.0 Obesity due to excess calories	0.211	0.788
E85.4 Organ-limited amyloidosis	0.214	0.786
L40.8 Other psoriasis	0.216	0.784
M49 Spondylopathies in diseases classified elsewhere	0.216	0.784
M24.01 Loose body in joint (Shoulder region)	0.219	0.781
E11.0 With coma	0.219	0.781
E74 Other disorders of carbohydrate metabolism	0.220	0.779
E11.6 With other specified complications	0.221	0.779
M24.7 Protrusio acetabuli	0.223	0.777
E78.1 Pure hyperglyceridaemia	0.229	0.771
E14.4 With neurological complications	0.229	0.771
M25.97 Joint disorder, unspecified (Ankle and foot)	0.229	0.771
E89.3 Postprocedural hypopituitarism	0.230	0.770
E78.8 Other disorders of lipoprotein metabolism	0.233	0.767
E78.6 Lipoprotein deficiency	0.236	0.764
E23 Hypofunction and other disorders of pituitary gland	0.238	0.762
M24.07 Loose body in joint (Ankle and foot)	0.239	0.761
M06.8 Other specified rheumatoid arthritis	0.239	0.761
E65 Localised adiposity	0.241	0.759
E16.0 Drug-induced hypoglycaemia without coma	0.242	0.758
M06.98 Rheumatoid arthritis, unspecified (Other)	0.244	0.756
M24.04 Loose body in joint (Hand)	0.250	0.750
M00-M03 Infectious arthropathies	0.250	0.750
M62 Other disorders of muscle	0.253	0.747
M36 Systemic disorders of connective tissue in diseases classified elsewhere	0.260	0.740
M33.1 Other dermatomyositis	0.261	0.739
M95-M99 Other disorders of the musculoskeletal system and connective tissue	0.261	0.738
M24.86 Other specific joint derangements, not elsewhere classified (Lower leg)	0.266	0.734
M24.26 Disorder of ligament (Lower leg)	0.270	0.729
E79 Disorders of purine and pyrimidine metabolism	0.271	0.729
M25.59 Pain in joint (Site unspecified)	0.272	0.728
E11.4 With neurological complications	0.275	0.725
M24.23 Disorder of ligament (Forearm)	0.275	0.725
E26 Hyperaldosteronism	0.276	0.724
M62.8 Other specified disorders of muscle	0.277	0.723
E14.5 With peripheral circulatory complications	0.280	0.720
M24.03 Loose body in joint (Forearm)	0.283	0.717
E05.5 Thyroid crisis or storm	0.283	0.717
E05.4 Thyrotoxicosis factitia	0.283	0.717
E05.3 Thyrotoxicosis from ectopic thyroid tissue	0.283	0.717
E05.1 Thyrotoxicosis with toxic single thyroid nodule	0.283	0.717
E10.7 With multiple complications	0.283	0.717
E12 Malnutrition-related diabetes mellitus	0.283	0.717
L40.4 Guttate psoriasis	0.283	0.717
L40.2 Acrodermatitis continua	0.283	0.717
M09 Juvenile arthritis in diseases classified elsewhere	0.283	0.717
M45.X8 Ankylosing spondylitis (Sacral and sacrococcygeal region)	0.283	0.717
M45.X7 Ankylosing spondylitis (Lumbosacral region)	0.283	0.717
M45.X5 Ankylosing spondylitis (Thoracolumbar region)	0.283	0.717
M45.X4 Ankylosing spondylitis (Thoracic region)	0.283	0.717
M45.X3 Ankylosing spondylitis (Cervicothoracic region)	0.283	0.717
M45.X1 Ankylosing spondylitis (Occipito-atlanto-axial region)	0.283	0.717
E11.7 With multiple complications	0.283	0.717
M07.38 Other psoriatic arthropathies (Other)	0.283	0.717
M07.34 Other psoriatic arthropathies (Hand)	0.283	0.717
M07.33 Other psoriatic arthropathies (Forearm)	0.283	0.717
M07.32 Other psoriatic arthropathies (Upper arm)	0.283	0.717
M07.31 Other psoriatic arthropathies (Shoulder region)	0.283	0.717
M06.2 Rheumatoid bursitis	0.283	0.717
M06.1 Adult-onset Still's disease	0.283	0.717
E01 Iodine-deficiency-related thyroid disorders and allied conditions	0.283	0.717
E00 Congenital iodine-deficiency syndrome	0.283	0.717
M07.5 Arthropathy in ulcerative colitis	0.283	0.717
M07.4 Arthropathy in Crohn's disease [regional enteritis]	0.283	0.717
M07.2 Psoriatic spondylitis	0.283	0.717
M07.1 Arthritis mutilans	0.283	0.717
M07.0 Distal interphalangeal psoriatic arthropathy	0.283	0.717
E14.7 With multiple complications	0.284	0.716
E14.2 Withrenal complications	0.285	0.715
L43.9 Lichen planus, unspecified	0.285	0.715
M24.5 Contracture of joint	0.286	0.714
M35.9 Systemic involvement of connective tissue, unspecified	0.286	0.714
M35.6 Relapsing panniculitis [Weber-Christian]	0.286	0.714
M35.5 Multifocal fibrosclerosis	0.286	0.714
M35.4 Diffuse (eosinophilic) fasciitis	0.286	0.714
E23.7 Disorder of pituitary gland, unspecified	0.288	0.712
E24 Cushing's syndrome	0.290	0.710
E61 Deficiency of other nutrient elements	0.291	0.709
M24.9 Joint derangement, unspecified	0.291	0.709
E05.2 Thyrotoxicosis with toxic multinodular goitre	0.293	0.707
M11 Other crystal arthropathies	0.296	0.704
E06.5 Other chronic thyroiditis	0.296	0.704
M24.16 Other articular cartilage disorders (Lower leg)	0.296	0.704
M25.50 Pain in joint (Multiple sites)	0.296	0.704
M08 Juvenile arthritis	0.297	0.703
M05.9 Seropositive rheumatoid arthritis, unspecified	0.297	0.703
E15 Nondiabetic hypoglycaemic coma	0.299	0.701
E10.0 With coma	0.301	0.699
M93 Other osteochondropathies	0.301	0.699
L40.3 Pustulosis palmaris et plantaris	0.303	0.697
E66.2 Extreme obesity with alveolar hypoventilation	0.303	0.696
E14.0 With coma	0.306	0.694
M24.6 Ankylosis of joint	0.306	0.694
M25.4 Effusion of joint	0.307	0.693
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)	0.309	0.691
E14.6 With other specified complications	0.309	0.691
E22 Hyperfunction of pituitary gland	0.310	0.690
E16.9 Disorder of pancreatic internal secretion, unspecified	0.310	0.690
E16.8 Other specified disorders of pancreatic internal secretion	0.310	0.690
E16.4 Abnormal secretion of gastrin	0.310	0.690
E16.3 Increased secretion of glucagon	0.310	0.690
E77 Disorders of glycoprotein metabolism	0.310	0.689
E76 Disorders of glycosaminoglycan metabolism	0.310	0.689
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism	0.310	0.689
E90 Nutritional and metabolic disorders in diseases classified elsewhere	0.310	0.689
E40-E46 Malnutrition	0.311	0.689
M24.06 Loose body in joint-Lower leg	0.311	0.689
E67 Other hyperalimentation	0.311	0.689
E68 Sequelae of hyperalimentation	0.311	0.689
E10.6 With other specified complications	0.312	0.688
E06.4 Drug-induced thyroiditis	0.313	0.687
E06.2 Chronic thyroiditis with transient thyrotoxicosis	0.313	0.687
E06.1 Subacute thyroiditis	0.313	0.687
E06.0 Acute thyroiditis	0.313	0.687
M34.8 Other forms of systemic sclerosis	0.316	0.684
L43.8 Other lichen planus	0.316	0.684
M24.17 Other articular cartilage disorders (Ankle and foot)	0.316	0.684
M32.1 Systemic lupus erythematosus with organ or system involvement	0.319	0.681
E89.0 Postprocedural hypothyroidism	0.319	0.681
M24.09 Loose body in joint (Site unspecified)	0.320	0.680
M24.08 Loose body in joint (Other)	0.320	0.680
M24.05 Loose body in joint (Pelvic region and thigh)	0.320	0.680
M24.00 Loose body in joint (Multiple sites)	0.320	0.680
M25.6 Stiffness of joint, not elsewhere classified	0.320	0.680
M25.96 Joint disorder, unspecified (Lower leg)	0.323	0.677
E74.3 Other disorders of intestinal carbohydrate absorption	0.326	0.674
E70 Disorders of aromatic amino-acid metabolism	0.326	0.674
M62.81 Other specified disorders of muscle (Shoulder region)	0.327	0.673
M06.32 Rheumatoid nodule (Upper arm)	0.327	0.673
E02 Subclinical iodine-deficiency hypothyroidism	0.331	0.669
E05.8 Other thyrotoxicosis	0.332	0.668
E27 Other disorders of adrenal gland	0.332	0.668
E21.2 Other hyperparathyroidism	0.333	0.667
M34.9 Systemic sclerosis, unspecified	0.334	0.666
M07.6 Other enteropathic arthropathies	0.334	0.666
E84 Cystic fibrosis	0.334	0.666
M24.29 Disorder of ligament (Site unspecified)	0.336	0.664
M24.25 Disorder of ligament (Pelvic region and thigh)	0.336	0.664
M24.22 Disorder of ligament (Upper arm)	0.336	0.664
M24.20 Disorder of ligament (Multiple sites)	0.336	0.664
E66.1 Drug-induced obesity	0.338	0.661
E16.1 Other hypoglycaemia	0.339	0.661
M25.93 Joint disorder, unspecified (Forearm)	0.342	0.657
E35 Disorders of endocrine glands in diseases classified elsewhere	0.343	0.656
E32 Diseases of thymus	0.343	0.656
E30 Disorders of puberty, not elsewhere classified	0.343	0.656
E25 Adrenogenital disorders	0.343	0.656
M24.21 Disorder of ligament (Shoulder region)	0.345	0.655
E51 Thiamine deficiency	0.345	0.654
E78.9 Disorder of lipoprotein metabolism, unspecified	0.347	0.653
M34.2 Systemic sclerosis induced by drugs and chemicals	0.349	0.651
M34.0 Progressive systemic sclerosis	0.349	0.651
E78.4 Other hyperlipidaemia	0.350	0.650
M94 Other disorders of cartilage	0.350	0.649
E72 Other disorders of amino-acid metabolism	0.351	0.648
E78.3 Hyperchylomicronaemia	0.351	0.648
M24.82 Other specific joint derangements, not elsewhere classified (Upper arm)	0.352	0.648
E61.1 Iron deficiency	0.356	0.644
M07.35 Other psoriatic arthropathies (Pelvic region and thigh)	0.357	0.643
M62.85 Other specified disorders of muscle (Pelvic region and thigh)	0.357	0.643
E89.6 Postprocedural adrenocortical(-medullary) hypofunction	0.358	0.642
M25.94 Joint disorder, unspecified (Hand)	0.359	0.641
M25.66 Stiffness of joint, not elsewhere classified (Lower leg)	0.361	0.639
E11.8 With unspecified complications	0.364	0.636
E85.9 Amyloidosis, unspecified	0.364	0.636
M25.2 Flail joint	0.368	0.632
M25.1 Fistula of joint	0.368	0.632
M49.5 Collapsed vertebra in diseases classified elsewhere	0.369	0.631
M24.3 Pathological dislocation and subluxation of joint, not elsewhere classified	0.371	0.629
M25.53 Pain in joint (Forearm)	0.371	0.629
M24.75 Protrusio acetabuli-Pelvic/thigh	0.374	0.626
M06.4 Inflammatory polyarthropathy	0.376	0.624
M06.37 Rheumatoid nodule (Ankle and foot)	0.376	0.624
M02 Reactive arthropathies	0.377	0.623
E21.4 Other specified disorders of parathyroid gland	0.377	0.623
E75 Disorders of sphingolipid metabolism and other lipid storage disorders	0.378	0.621
E58 Dietary calcium deficiency	0.380	0.620
M33.2 Polymyositis	0.380	0.620
E23.6 Other disorders of pituitary gland	0.385	0.615
M12 Other specific arthropathies	0.386	0.614
E31 Polyglandular dysfunction	0.389	0.611
E21.0 Primary hyperparathyroidism	0.390	0.610
M33.9 Dermatopolymyositis, unspecified	0.390	0.609
M33.0 Juvenile dermatomyositis	0.390	0.609
E07 Other disorders of thyroid	0.392	0.608
E89.9 Postprocedural endocrine and metabolic disorder, unspecified	0.394	0.606
E89.8 Other postprocedural endocrine and metabolic disorders	0.394	0.606
E89.5 Postprocedural testicular hypofunction	0.394	0.606
E89.1 Postprocedural hypoinsulinaemia	0.394	0.606
E85.2 Heredofamilial amyloidosis, unspecified	0.395	0.605
E85.1 Neuropathic heredofamilial amyloidosis	0.395	0.605
E85.0 Nonneuropathic heredofamilial amyloidosis	0.395	0.605
M24.85 Other specific joint derangements, not elsewhere classified (Pelvic region and thigh)	0.395	0.605
M06.30 Rheumatoid nodule (Multiple sites)	0.396	0.604
E22.0 Acromegaly and pituitary gigantism	0.397	0.603
M25.43 Effusion of joint (Forearm)	0.398	0.602
E21.5 Disorder of parathyroid gland, unspecified	0.399	0.601
L44 Other papulosquamous disorders	0.400	0.600
L41 Parapsoriasis	0.400	0.600
L45 Papulosquamous disorders in diseases classified elsewhere	0.400	0.600
M91 Juvenile osteochondrosis of hip and pelvis	0.400	0.600
M25.99 Joint disorder, unspecified (Site unspecified)	0.403	0.597
M25.98 Joint disorder, unspecified (Other)	0.403	0.597
M25.92 Joint disorder, unspecified (Upper arm)	0.403	0.597
M25.90 Joint disorder, unspecified (Multiple sites)	0.403	0.597
M25.0 Haemarthrosis	0.403	0.596
M93.9 Osteochondropathy, unspecified	0.404	0.596
M63 Disorders of muscle in diseases classified elsewhere	0.405	0.595
M61 Calcification and ossification of muscle	0.405	0.595
M80-M85 Disorders of bone density and structure	0.405	0.595
E34 Other endocrine disorders	0.406	0.593
M25.3 Other instability of joint	0.407	0.593
E21.1 Secondary hyperparathyroidism, not elsewhere classified	0.408	0.592
M62.86 Other specified disorders of muscle (Lower leg)	0.409	0.591
M62.82 Other specified disorders of muscle (Upper arm)	0.410	0.590
M06.89 Other specified rheumatoid arthritis (Site unspecified)	0.410	0.589
E27.1 Primary adrenocortical insufficiency	0.411	0.589
M14 Arthropathies in other diseases classified elsewhere	0.413	0.586
E26.0 Primary hyperaldosteronism	0.414	0.586
E56 Other vitamin deficiencies	0.414	0.586
M30 Polyarteritis nodosa and related conditions	0.416	0.583
M35.8 Other specified systemic involvement of connective tissue	0.417	0.583
E89.4 Postprocedural ovarian failure	0.418	0.582
E73 Lactose intolerance	0.420	0.579
M05.94 Seropositive rheumatoid arthritis, unspecified (Hand)	0.424	0.576
E64 Sequelae of malnutrition and other nutritional deficiencies	0.425	0.575
E63 Other nutritional deficiencies	0.425	0.575
E50 Vitamin A deficiency	0.425	0.575
E60 Dietary zinc deficiency	0.425	0.575
E59 Dietary selenium deficiency	0.425	0.575
E52 Niacin deficiency [pellagra]	0.425	0.575
M06.39 Rheumatoid nodule (Site unspecified)	0.426	0.574
M06.38 Rheumatoid nodule (Other)	0.426	0.574
M06.36 Rheumatoid nodule (Lower leg)	0.426	0.574
M06.35 Rheumatoid nodule (Pelvic region and thigh)	0.426	0.574
M06.31 Rheumatoid nodule (Shoulder region)	0.426	0.574
E13 Other specified diabetes mellitus	0.426	0.574
M32.9 Systemic lupus erythematosus, unspecified	0.426	0.574
M32.0 Drug-induced systemic lupus erythematosus	0.426	0.574
M24.89 Other specific joint derangements, not elsewhere classified (Site unspecified)	0.427	0.573
M24.80 Other specific joint derangements, not elsewhere classified (Multiple sites)	0.427	0.573
M05.90 Seropositive rheumatoid arthritis, unspecified (Multiple sites)	0.427	0.573
M24.19 Other articular cartilage disorders (Site unspecified)	0.429	0.570
M24.18 Other articular cartilage disorders (Other)	0.429	0.570
M24.14 Other articular cartilage disorders (Hand)	0.429	0.570
M24.12 Other articular cartilage disorders (Upper arm)	0.429	0.570
M24.10 Other articular cartilage disorders (Multiple sites)	0.429	0.570
M96 Postprocedural musculoskeletal disorders, not elsewhere classified	0.430	0.570
M05.3 Rheumatoid arthritis with involvement of other organs and systems	0.431	0.569
M05.1 Rheumatoid lung disease	0.431	0.569
M05.0 Felty's syndrome	0.431	0.569
M24.83 Other specific joint derangements, not elsewhere classified (Forearm)	0.433	0.567
E24.2 Drug-induced Cushing's syndrome	0.433	0.567
L43.3 Subacute (active) lichen planus	0.435	0.565
L43.2 Lichenoid drug reaction	0.435	0.565
L43.1 Bullous lichen planus	0.435	0.565
L43.0 Hypertrophic lichen planus	0.435	0.565
E85.8 Other amyloidosis	0.435	0.565
E27.3 Drug-induced adrenocortical insufficiency	0.436	0.564
M25.91 Joint disorder, unspecified (Shoulder region)	0.436	0.564
M95 Other acquired deformities of musculoskeletal system and connective tissue	0.436	0.564
M24.51 Contracture of joint (Shoulder region)	0.437	0.563
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease	0.438	0.562
M94.2 Chondromalacia	0.438	0.562
M49.8 Spondylopathy in other diseases classified elsewhere	0.438	0.562
M49.4 Neuropathic spondylopathy	0.438	0.562
M49.3 Spondylopathy in other infectious and parasitic diseases classified elsewhere	0.438	0.562
M49.2 Enterobacterial spondylitis	0.438	0.562
M49.1 Brucella spondylitis	0.438	0.562
M49.0 Tuberculosis of spine	0.438	0.562
E20 Hypoparathyroidism	0.439	0.560
M24.56 Contracture of joint (Lower leg)	0.440	0.560
E29 Testicular dysfunction	0.441	0.559
E74.9 Disorder of carbohydrate metabolism, unspecified	0.441	0.559
E74.8 Other specified disorders of carbohydrate metabolism	0.441	0.559
E74.4 Disorders of pyruvate metabolism and gluconeogenesis	0.441	0.559
E74.2 Disorders of galactose metabolism	0.441	0.559
E74.1 Disorders of fructose metabolism	0.441	0.559
M24.79 Protrusio acetabuli-Site unspec	0.443	0.557
M24.78 Protrusio acetabuli-Other	0.443	0.557
M24.77 Protrusio acetabuli-Ankle/foot	0.443	0.557
M24.76 Protrusio acetabuli-Lower leg	0.443	0.557
M24.74 Protrusio acetabuli-Hand	0.443	0.557
M24.73 Protrusio acetabuli-Forearm	0.443	0.557
M24.72 Protrusio acetabuli-Upper arm	0.443	0.557
M24.71 Protrusio acetabuli-Shldr region	0.443	0.557
M24.70 Protrusio acetabuli-Mult sites	0.443	0.557
E24.0 Pituitary-dependent Cushing's disease	0.445	0.555
M36.8 Systemic disorders of connective tissue in other diseases classified elsewhere	0.445	0.554
M82 Osteoporosis in diseases classified elsewhere	0.446	0.554
K90 Intestinal malabsorption	0.447	0.553
M02.3 Reiter's disease	0.450	0.550
M25.42 Effusion of joint (Upper arm)	0.450	0.550
E51.2 Wernicke's encephalopathy	0.451	0.549
E23.3 Hypothalamic dysfunction, not elsewhere classified	0.454	0.546
E23.1 Drug-induced hypopituitarism	0.454	0.546
M05.99 Seropositive rheumatoid arthritis, unspecified (Site unspecified)	0.454	0.546
M06.88 Other specified rheumatoid arthritis (Other)	0.454	0.545
M06.87 Other specified rheumatoid arthritis (Ankle and foot)	0.454	0.545
M06.86 Other specified rheumatoid arthritis (Lower leg)	0.454	0.545
M06.85 Other specified rheumatoid arthritis (Pelvic region and thigh)	0.454	0.545
M06.84 Other specified rheumatoid arthritis (Hand)	0.454	0.545
M06.83 Other specified rheumatoid arthritis (Forearm)	0.454	0.545
M06.82 Other specified rheumatoid arthritis (Upper arm)	0.454	0.545
M06.81 Other specified rheumatoid arthritis (Shoulder region)	0.454	0.545
M06.80 Other specified rheumatoid arthritis (Multiple sites)	0.454	0.545
E54 Ascorbic acid deficiency	0.456	0.544
M96.0 Pseudarthrosis after fusion or arthrodesis	0.456	0.544
M06.0 Seronegative rheumatoid arthritis	0.456	0.544
M25.57 Pain in joint (Ankle and foot)	0.458	0.542
M62.0 Diastasis of muscle	0.458	0.542
M03 Postinfective and reactive arthropathies in diseases classified elsewhere	0.462	0.538
M01 Direct infections of joint in infectious and parasitic diseases classified elsewhere	0.462	0.538
M62.1 Other rupture of muscle (nontraumatic)	0.463	0.537
M25.60 Stiffness of joint, not elsewhere classified (Multiple sites)	0.463	0.537
L42 Pityriasis rosea	0.464	0.536
M62.4 Contracture of muscle	0.464	0.536
M62.3 Immobility syndrome (paraplegic)	0.464	0.536
M62.2 Ischaemic infarction of muscle	0.464	0.536
M93.1 Kienbock's disease of adults	0.464	0.536
E03 Other hypothyroidism	0.464	0.536
M25.95 Joint disorder, unspecified (Pelvic region and thigh)	0.467	0.533
M24.67 Ankylosis of joint (Ankle and foot)	0.467	0.533
M06.33 Rheumatoid nodule (Forearm)	0.468	0.532
H36.0 Diabetic retinopathy	0.469	0.531
M36.4 Arthropathy in hypersensitivity reactions classified elsewhere	0.469	0.530
M36.3 Arthropathy in other blood disorders	0.469	0.530
M36.2 Haemophilic arthropathy	0.469	0.530
M36.1 Arthropathy in neoplastic disease	0.469	0.530
M36.0 Dermato(poly)myositis in neoplastic disease	0.469	0.530
M32.8 Other forms of systemic lupus erythematosus	0.470	0.530
E27.9 Disorder of adrenal gland, unspecified	0.471	0.529
M25.68 Stiffness of joint, not elsewhere classified (Other)	0.471	0.529
M11.9 Crystal arthropathy, unspecified	0.472	0.528
M24.88 Other specific joint derangements, not elsewhere classified (Other)	0.473	0.527
M05.8 Other seropositive rheumatoid arthritis	0.473	0.526
M25.63 Stiffness of joint, not elsewhere classified (Forearm)	0.475	0.525
M82.1 Osteoporosis in endocrine disorders	0.476	0.524
E55 Vitamin D deficiency	0.476	0.524
E79.9 Disorder of purine and pyrimidine metabolism, unspecified	0.477	0.523
E79.8 Other disorders of purine and pyrimidine metabolism	0.477	0.523
E79.1 Lesch-Nyhan syndrome	0.477	0.523
M21 Other acquired deformities of limbs	0.478	0.522
E26.9 Hyperaldosteronism, unspecified	0.481	0.519
E26.8 Other hyperaldosteronism	0.481	0.519
E26.1 Secondary hyperaldosteronism	0.481	0.519
M62.87 Other specified disorders of muscle (Ankle and foot)	0.482	0.518
M25.40 Effusion of joint (Multiple sites)	0.482	0.518
M80 Osteoporosis with pathological fracture	0.483	0.517
M62.84 Other specified disorders of muscle (Hand)	0.484	0.516
E12.9 Without complications	0.486	0.514
E12.8 With unspecified complications	0.486	0.514
E12.7 With multiple complications	0.486	0.514
E12.6 With other specified complications	0.486	0.514
E12.5 With peripheral circulatory complications	0.486	0.514
E12.4 With neurological complications	0.486	0.514
E12.3 With ophthalmic complications	0.486	0.514
E12.2 With renal complications	0.486	0.514
E12.1 With ketoacidosis	0.486	0.514
E12.0 With coma	0.486	0.514
M09.8 Juvenile arthritis in other diseases classified elsewhere	0.486	0.514
M09.2 Juvenile arthritis in ulcerative colitis	0.486	0.514
M09.1 Juvenile arthritis in Crohn's disease [regional enteritis]	0.486	0.514
M09.0 Juvenile arthritis in psoriasis	0.486	0.514
E00.9 Congenital iodine-deficiency syndrome, unspecified	0.486	0.514
E00.2 Congenital iodine-deficiency syndrome, mixed type	0.486	0.514
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type	0.486	0.514
E00.0 Congenital iodine-deficiency syndrome, neurological type	0.486	0.514
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions	0.486	0.514
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified	0.486	0.514
E01.1 Iodine-deficiency-related multinodular (endemic) goitre	0.486	0.514
E01.0 Iodine-deficiency-related diffuse (endemic) goitre	0.486	0.514
M06.19 Adult-onset Still's disease (Site unspecified)	0.486	0.514
M06.18 Adult-onset Still's disease (Other)	0.486	0.514
M06.17 Adult-onset Still's disease (Ankle and foot)	0.486	0.514
M06.16 Adult-onset Still's disease (Lower leg)	0.486	0.514
M06.15 Adult-onset Still's disease (Pelvic region and thigh)	0.486	0.514
M06.14 Adult-onset Still's disease (Hand)	0.486	0.514
M06.13 Adult-onset Still's disease (Forearm)	0.486	0.514
M06.12 Adult-onset Still's disease (Upper arm)	0.486	0.514
M06.11 Adult-onset Still's disease (Shoulder region)	0.486	0.514
M06.10 Adult-onset Still's disease (Multiple sites)	0.486	0.514
M06.29 Rheumatoid bursitis (Site unspecified)	0.486	0.514
M06.28 Rheumatoid bursitis (Other)	0.486	0.514
M06.27 Rheumatoid bursitis (Ankle and foot)	0.486	0.514
M06.26 Rheumatoid bursitis (Lower leg)	0.486	0.514
M06.25 Rheumatoid bursitis (Pelvic region and thigh)	0.486	0.514
M06.24 Rheumatoid bursitis (Hand)	0.486	0.514
M06.23 Rheumatoid bursitis (Forearm)	0.486	0.514
M06.22 Rheumatoid bursitis (Upper arm)	0.486	0.514
M06.21 Rheumatoid bursitis (Shoulder region)	0.486	0.514
M06.20 Rheumatoid bursitis (Multiple sites)	0.486	0.514
M07.09 Distal interphalangeal psoriatic arthropathy (Site unspecified)	0.486	0.514
M07.08 Distal interphalangeal proriatic arthropathy-Other	0.486	0.514
M07.07 Distal interphalangeal psoriatic arthropathy (Ankle and foot)	0.486	0.514
M07.06 Distal interphalangeal proriatic arthropathy-Lower leg	0.486	0.514
M07.05 Distal interphalangeal proriatic arthropathy-Pelvic/thigh	0.486	0.514

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations