TreeWAS – Variant ID: rs2523589

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	Risk posterior probability	No effect posterior probability	Protective posterior probability
K90.0 Coeliac disease	0.000	0.000	1.000
M45.X9 Ankylosing spondylitis (Site unspecified)	0.000	0.000	1.000
E05 Thyrotoxicosis [hyperthyroidism]	0.000	0.000	1.000
G35 Multiple sclerosis	0.000	0.000	1.000
M45 Ankylosing spondylitis	0.000	0.000	1.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	0.000	0.000	1.000
E05.0 Thyrotoxicosis with diffuse goitre	0.000	0.000	1.000
E00-E07 Disorders of thyroid gland	0.000	0.000	1.000
Chapter IV Endocrine, nutritional and metabolic diseases	0.000	0.000	1.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue	0.000	0.000	1.000
# Top node	0.000	0.000	1.000
M35.0 Sicca syndrome [Sjogren]	0.000	0.000	1.000
M20-M25 Other joint disorders	0.000	0.000	1.000
D80-D89 Certain disorders involving the immune mechanism	0.000	0.000	1.000
M35 Other systemic involvement of connective tissue	0.000	0.000	1.000
M45.X0 Ankylosing spondylitis (Multiple sites in spine)	0.000	0.001	0.999
M45-M49 Spondylopathies	0.000	0.001	0.999
Chapter VII Diseases of the eye and adnexa	0.000	0.002	0.998
R31 Unspecified haematuria	0.998	0.002	0.000
H15-H22 Disorders of sclera, cornea, iris and ciliary body	0.000	0.002	0.998
E05.9 Thyrotoxicosis, unspecified	0.000	0.002	0.998
H20 Iridocyclitis	0.000	0.003	0.997
H20.9 Iridocyclitis, unspecified	0.000	0.004	0.996
G35-G37 Demyelinating diseases of the central nervous system	0.000	0.006	0.994
D89 Other disorders involving the immune mechanism, not elsewhere classified	0.000	0.008	0.992
E03 Other hypothyroidism	0.000	0.008	0.992
D86 Sarcoidosis	0.000	0.008	0.992
D50-D53 Nutritional anaemias	0.000	0.009	0.991
Chapter VI Diseases of the nervous system	0.000	0.012	0.988
M00-M03 Infectious arthropathies	0.000	0.012	0.988
E03.9 Hypothyroidism, unspecified	0.000	0.014	0.986
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions	0.000	0.014	0.986
E10-E14 Diabetes mellitus	0.000	0.016	0.984
D69 Purpura and other haemorrhagic conditions	0.000	0.016	0.984
E50-E64 Other nutritional deficiencies	0.000	0.019	0.981
E10 Insulin-dependent diabetes mellitus	0.000	0.021	0.979
E78.0 Pure hypercholesterolaemia	0.977	0.023	0.000
D69.6 Thrombocytopenia, unspecified	0.000	0.025	0.975
D89.2 Hypergammaglobulinaemia, unspecified	0.000	0.027	0.973
E10.3 With ophthalmic complications	0.000	0.027	0.973
D51 Vitamin B12 deficiency anaemia	0.000	0.027	0.973
D86.9 Sarcoidosis, unspecified	0.000	0.032	0.968
N47 Redundant prepuce, phimosis and paraphimosis	0.957	0.043	0.000
M23 Internal derangement of knee	0.000	0.043	0.957
E10.2 With renal complications	0.000	0.044	0.956
M02 Reactive arthropathies	0.000	0.046	0.954
M34 Systemic sclerosis	0.000	0.049	0.951
M23.4 Loose body in knee	0.000	0.050	0.950
E53 Deficiency of other B group vitamins	0.000	0.052	0.948
H00-H06 Disorders of eyelid, lacrimal system and orbit	0.000	0.054	0.946
M23.49 Loose body in knee-Unspec lig/men	0.000	0.056	0.944
G30-G32 Other degenerative diseases of the nervous system	0.000	0.064	0.936
M07.3 Other psoriatic arthropathies	0.000	0.068	0.932
D51.9 Vitamin B12 deficiency anaemia, unspecified	0.000	0.068	0.932
M07 Psoriatic and enteropathic arthropathies	0.000	0.073	0.927
N40-N51 Diseases of male genital organs	0.927	0.073	0.000
D86.0 Sarcoidosis of lung	0.000	0.074	0.926
N42 Other disorders of prostate	0.925	0.075	0.000
M05-M14 Inflammatory polyarthropathies	0.000	0.076	0.924
N48 Other disorders of penis	0.921	0.079	0.000
D50 Iron deficiency anaemia	0.000	0.081	0.919
E53.8 Deficiency of other specified B group vitamins	0.000	0.081	0.919
D60-D64 Aplastic and other anaemias	0.000	0.082	0.918
M22 Disorders of patella	0.000	0.082	0.918
N42.8 Other specified disorders of prostate	0.916	0.084	0.000
M07.39 Other psoriatic arthropathies (Site unspecified)	0.000	0.084	0.916
M00 Pyogenic arthritis	0.000	0.084	0.916
D61 Other aplastic anaemias	0.000	0.088	0.912
N48.6 Balanitis xerotica obliterans	0.910	0.090	0.000
D80 Immunodeficiency with predominantly antibody defects	0.000	0.091	0.909
H46-H48 Disorders of optic nerve and visual pathways	0.000	0.092	0.908
H06 Disorders of lachrymal system and orbit in diseases classified elsewhere	0.000	0.093	0.907
D61.9 Aplastic anaemia, unspecified	0.000	0.093	0.907
G31 Other degenerative diseases of nervous system, not elsewhere classified	0.000	0.105	0.895
D51.0 Vitamin B12 deficiency anaemia due to intrinsic factor deficiency	0.000	0.105	0.895
M07.30 Other psoriatic arthropathies (Multiple sites)	0.000	0.105	0.895
K90 Intestinal malabsorption	0.000	0.106	0.894
M02.3 Reiter's disease	0.000	0.108	0.892
E55 Vitamin D deficiency	0.000	0.112	0.888
M45.X2 Ankylosing spondylitis (Cervical region)	0.000	0.115	0.885
H10-H13 Disorders of conjunctiva	0.000	0.118	0.882
H06.2 Dysthyroid exophthalmos	0.000	0.121	0.879
N42.1 Congestion and haemorrhage of prostate	0.879	0.121	0.000
H46 Optic neuritis	0.000	0.121	0.879
H18 Other disorders of cornea	0.000	0.123	0.877
M22.2 Patellofemoral disorders	0.000	0.129	0.871
M35.7 Hypermobility syndrome	0.000	0.130	0.870
H16 Keratitis	0.000	0.131	0.869
D50.9 Iron deficiency anaemia, unspecified	0.000	0.138	0.862
H02 Other disorders of eyelid	0.000	0.142	0.858
D89.0 Polyclonal hypergammaglobulinaemia	0.000	0.142	0.858
D69.5 Secondary thrombocytopenia	0.000	0.145	0.855
H02.0 Entropion and trichiasis of eyelid	0.000	0.147	0.853
G31.9 Degenerative disease of nervous system, unspecified	0.000	0.149	0.851
H02.5 Other disorders affecting eyelid function	0.000	0.150	0.850
M02.39 Reiter's disease (Site unspecified)	0.000	0.152	0.848
M21 Other acquired deformities of limbs	0.000	0.152	0.848
M02.9 Reactive arthopathy, unspecified	0.000	0.152	0.847
M00.9 Pyogenic arthritis, unspecified	0.000	0.154	0.846
E14 Unspecified diabetes mellitus	0.000	0.154	0.846
K90.9 Intestinal malabsorption, unspecified	0.000	0.156	0.844
H20.1 Chronic iridocyclitis	0.000	0.157	0.843
D86.1 Sarcoidosis of lymph nodes	0.000	0.161	0.839
D69.4 Other primary thrombocytopenia	0.000	0.165	0.835
M34.8 Other forms of systemic sclerosis	0.000	0.165	0.835
D69.2 Other nonthrombocytopenic purpura	0.000	0.165	0.835
Chapter XII Diseases of the skin and subcutaneous tissue	0.000	0.168	0.832
M45.X6 Ankylosing spondylitis (Lumbar region)	0.000	0.172	0.828
M33 Dermatopolymyositis	0.000	0.174	0.826
M34.9 Systemic sclerosis, unspecified	0.000	0.174	0.826
M21.0 Valgus deformity, not elsewhere classified	0.000	0.174	0.826
M23.8 Other internal derangements of knee	0.000	0.175	0.825
H11 Other disorders of conjunctiva	0.000	0.177	0.823
E55.9 Vitamin D deficiency, unspecified	0.000	0.178	0.822
H05 Disorders of orbit	0.000	0.181	0.819
E03.8 Other specified hypothyroidism	0.000	0.184	0.816
E14.3 With ophthalmic complications	0.000	0.184	0.816
D69.3 Idiopathic thrombocytopenic purpura	0.000	0.190	0.810
H19 Disorders of sclera and cornea in diseases classified elsewhere	0.000	0.192	0.808
H11.0 Pterygium	0.000	0.193	0.807
M60-M63 Disorders of muscles	0.000	0.195	0.805
L50-L54 Urticaria and erythema	0.000	0.199	0.801
E51 Thiamine deficiency	0.000	0.214	0.785
M07.34 Other psoriatic arthropathies (Hand)	0.000	0.215	0.785
D80.1 Nonfamilial hypogammaglobulinaemia	0.000	0.216	0.784
H03 Disorders of eyelid in diseases classified elsewhere	0.000	0.217	0.783
M22.8 Other disorders of patella	0.000	0.219	0.781
M32 Systemic lupus erythematosus	0.000	0.220	0.780
M34.0 Progressive systemic sclerosis	0.000	0.224	0.776
H16.0 Corneal ulcer	0.000	0.225	0.775
E10.1 With ketoacidosis	0.000	0.229	0.771
M00.96 Pyogenic arthritis, unspecified (Lower leg)	0.000	0.230	0.770
D65 Disseminated intravascular coagulation [defibrination syndrome]	0.000	0.230	0.770
M02.90 Reactive arthropathy, unspecified (Multiple sites)	0.000	0.232	0.768
M23.83 Other internal derangements of knee (Medial collateral ligament or Other and unspecified medial meniscus)	0.000	0.233	0.767
D89.9 Disorder involving the immune mechanism, unspecified	0.000	0.233	0.767
M21.06 Valgus deformity, not elsewhere classified (Lower leg)	0.000	0.233	0.767
D89.8 Other specified disorders involving the immune mechanism, not elsewhere classified	0.000	0.235	0.765
N48.9 Disorder of penis, unspecified	0.764	0.236	0.000
L50 Urticaria	0.000	0.236	0.764
N48.0 Leukoplakia of penis	0.762	0.238	0.000
M21.07 Valgus deformity, not elsewhere classified (Ankle and foot)	0.000	0.238	0.762
D83 Common variable immunodeficiency	0.000	0.241	0.759
G80-G83 Cerebral palsy and other paralytic syndromes	0.000	0.242	0.758
G31.2 Degeneration of nervous system due to alcohol	0.000	0.242	0.758
H20.0 Acute and subacute iridocyclitis	0.000	0.243	0.757
M23.6 Other spontaneous disruption of ligament(s) of knee	0.000	0.245	0.755
M23.5 Chronic instability of knee	0.000	0.247	0.753
D80.3 Selective deficiency of immunoglobulin G [IgG] subclasses	0.000	0.250	0.750
H18.1 Bullous keratopathy	0.000	0.252	0.748
M23.43 Loose body in knee-Med lig/oth men	0.000	0.252	0.748
M07.36 Other psoriatic arthropathies (Lower leg)	0.000	0.252	0.748
H18.3 Changes in corneal membranes	0.000	0.253	0.747
L52 Erythema nodosum	0.000	0.254	0.746
N48.8 Other specified disorders of penis	0.743	0.257	0.000
G36 Other acute disseminated demyelination	0.000	0.258	0.742
L50.9 Urticaria, unspecified	0.000	0.261	0.739
E58 Dietary calcium deficiency	0.000	0.262	0.738
M07.37 Other psoriatic arthropathies (Ankle and foot)	0.000	0.262	0.738
Chapter XVI Certain conditions originating in the perinatal period	0.000	0.266	0.734
D80.2 Selective deficiency of immunoglobulin A [IgA]	0.000	0.266	0.734
D86.3 Sarcoidosis of skin	0.000	0.266	0.733
N42.2 Atrophy of prostate	0.733	0.267	0.000
M07.35 Other psoriatic arthropathies (Pelvic region and thigh)	0.000	0.267	0.733
G37 Other demyelinating diseases of central nervous system	0.000	0.267	0.732
H22 Disorders of iris and ciliary body in diseases classified elsewhere	0.000	0.268	0.732
L55-L59 Radiation-related disorders of the skin and subcutaneous tissue	0.000	0.269	0.731
M23.1 Discoid meniscus (congenital)	0.000	0.271	0.729
G32 Other degenerative disorders of nervous system in diseases classified elsewhere	0.000	0.271	0.729
E56 Other vitamin deficiencies	0.000	0.272	0.728
E10.5 With peripheral circulatory complications	0.000	0.275	0.725
E53.9 Vitamin B deficiency, unspecified	0.000	0.276	0.724
H30-H36 Disorders of choroid and retina	0.000	0.276	0.724
M35.8 Other specified systemic involvement of connective tissue	0.000	0.278	0.722
M33.1 Other dermatomyositis	0.000	0.280	0.720
H18.6 Keratoconus	0.000	0.280	0.720
D50.1 Sideropenic dysphagia	0.000	0.281	0.719
M23.41 Loose body in knee-Ant lig/hrn men	0.000	0.282	0.717
E05.5 Thyroid crisis or storm	0.000	0.283	0.717
E05.4 Thyrotoxicosis factitia	0.000	0.283	0.717
E05.3 Thyrotoxicosis from ectopic thyroid tissue	0.000	0.283	0.717
E05.1 Thyrotoxicosis with toxic single thyroid nodule	0.000	0.283	0.717
M45.X8 Ankylosing spondylitis (Sacral and sacrococcygeal region)	0.000	0.283	0.717
M45.X7 Ankylosing spondylitis (Lumbosacral region)	0.000	0.283	0.717
M45.X5 Ankylosing spondylitis (Thoracolumbar region)	0.000	0.283	0.717
M45.X4 Ankylosing spondylitis (Thoracic region)	0.000	0.283	0.717
M45.X3 Ankylosing spondylitis (Cervicothoracic region)	0.000	0.283	0.717
M45.X1 Ankylosing spondylitis (Occipito-atlanto-axial region)	0.000	0.283	0.717
E01 Iodine-deficiency-related thyroid disorders and allied conditions	0.000	0.283	0.717
E00 Congenital iodine-deficiency syndrome	0.000	0.283	0.717
D81 Combined immunodeficiencies	0.000	0.283	0.717
M35.9 Systemic involvement of connective tissue, unspecified	0.000	0.283	0.717
M35.6 Relapsing panniculitis [Weber-Christian]	0.000	0.283	0.717
M35.5 Multifocal fibrosclerosis	0.000	0.283	0.717
M35.4 Diffuse (eosinophilic) fasciitis	0.000	0.283	0.717
N51 Disorders of male genital organs in diseases classified elsewhere	0.716	0.284	0.000
M23.46 Loose body in knee-O/unsp lat men	0.000	0.285	0.715
H20.2 Lens-induced iridocyclitis	0.000	0.285	0.715
D89.1 Cryoglobulinaemia	0.000	0.285	0.715
M00.0 Staphylococcal arthritis and polyarthritis	0.000	0.288	0.712
D89.3 Immune reconstitution syndrome	0.000	0.289	0.711
E03.5 Myxoedema coma	0.000	0.289	0.711
E03.4 Atrophy of thyroid (acquired)	0.000	0.289	0.711
E03.3 Postinfectious hypothyroidism	0.000	0.289	0.711
N48.4 Impotence of organic origin	0.709	0.291	0.000
M36 Systemic disorders of connective tissue in diseases classified elsewhere	0.000	0.291	0.709
D53 Other nutritional anaemias	0.000	0.291	0.708
M03 Postinfective and reactive arthropathies in diseases classified elsewhere	0.000	0.292	0.708
M01 Direct infections of joint in infectious and parasitic diseases classified elsewhere	0.000	0.292	0.708
D51.8 Other vitamin B12 deficiency anaemias	0.000	0.292	0.708
N48.5 Ulcer of penis	0.707	0.292	0.000
E12 Malnutrition-related diabetes mellitus	0.000	0.294	0.705
D69.8 Other specified haemorrhagic conditions	0.000	0.295	0.705
E64 Sequelae of malnutrition and other nutritional deficiencies	0.000	0.296	0.704
E63 Other nutritional deficiencies	0.000	0.296	0.704
E50 Vitamin A deficiency	0.000	0.296	0.704
E60 Dietary zinc deficiency	0.000	0.296	0.704
E59 Dietary selenium deficiency	0.000	0.296	0.704
E52 Niacin deficiency [pellagra]	0.000	0.296	0.704
E03.2 Hypothyroidism due to medicaments and other exogenous substances	0.000	0.297	0.703
E10.7 With multiple complications	0.000	0.298	0.702
M07.31 Other psoriatic arthropathies (Shoulder region)	0.000	0.299	0.701
H49-H52 Disorders of ocular muscles, binocular movement, accommodation and refraction	0.000	0.300	0.700
E03.1 Congenital hypothyroidism without goitre	0.000	0.301	0.699
D51.2 Transcobalamin II deficiency	0.000	0.302	0.698
D51.1 Vitamin B12 deficiency anaemia due to selective vitamin B12 malabsorption with proteinuria	0.000	0.302	0.698
H16.9 Keratitis, unspecified	0.000	0.303	0.697
M23.80 Other internal derangements of knee (Multiple sites)	0.000	0.304	0.696
E05.2 Thyrotoxicosis with toxic multinodular goitre	0.000	0.305	0.695
H36 Retinal disorders in diseases classified elsewhere	0.000	0.308	0.692
L10-L14 Bullous disorders	0.000	0.310	0.690
H05.2 Exophthalmic conditions	0.000	0.310	0.690
L20-L30 Dermatitis and eczema	0.000	0.311	0.689
M23.9 Internal derangement of knee, unspecified	0.000	0.315	0.685
M62 Other disorders of muscle	0.000	0.316	0.684
M02.8 Other reactive arthropathies	0.000	0.316	0.684
M02.2 Postimmunisation arthropathy	0.000	0.316	0.684
M02.1 Postdysenteric arthropathy	0.000	0.316	0.684
M02.0 Arthropathy following intestinal bypass	0.000	0.316	0.684
Chapter XXII Codes for special purposes	0.000	0.317	0.683
M34.1 CR(E)ST syndrome	0.000	0.318	0.682
M34.2 Systemic sclerosis induced by drugs and chemicals	0.000	0.318	0.682
N44 Torsion of testis	0.681	0.318	0.000
M23.47 Loose body in knee-Capsular lig	0.000	0.319	0.681
M23.45 Loose body in knee-Pst hrn lat men	0.000	0.319	0.681
M23.42 Loose body in knee-Pst lig/hrn men	0.000	0.319	0.681
E53.1 Pyridoxine deficiency	0.000	0.320	0.679
E53.0 Riboflavin deficiency	0.000	0.320	0.679
G00-G09 Inflammatory diseases of the central nervous system	0.000	0.321	0.679
K90.4 Malabsorption due to intolerance, not elsewhere classified	0.000	0.321	0.679
D61.1 Drug-induced aplastic anaemia	0.000	0.322	0.678
D61.0 Constitutional aplastic anaemia	0.000	0.322	0.678
H18.0 Corneal pigmentations and deposits	0.000	0.324	0.676
M07.6 Other enteropathic arthropathies	0.000	0.326	0.674
H50 Other strabismus	0.000	0.326	0.674
M23.44 Loose body in knee-Lat lig/ant men	0.000	0.327	0.673
E14.8 With unspecified complications	0.000	0.328	0.672
M22.3 Other derangements of patella	0.000	0.328	0.672
M00.8 Arthritis and polyarthritis due to other specified bacterial agents	0.000	0.330	0.670
H36.0 Diabetic retinopathy	0.000	0.330	0.670
M00.93 Pyogenic arthritis, unspecified (Forearm)	0.000	0.331	0.669
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion	0.000	0.331	0.669
M07.38 Other psoriatic arthropathies (Other)	0.000	0.332	0.668
M07.33 Other psoriatic arthropathies (Forearm)	0.000	0.332	0.668
M07.32 Other psoriatic arthropathies (Upper arm)	0.000	0.332	0.668
D84 Other immunodeficiencies	0.000	0.332	0.668
H05.0 Acute inflammation of orbit	0.000	0.333	0.667
G81 Hemiplegia	0.000	0.333	0.667
H11.8 Other specified disorders of conjunctiva	0.000	0.334	0.665
H03.1 Involvement of eyelid in other infectious diseases classified elsewhere	0.000	0.335	0.665
N42.0 Calculus of prostate	0.665	0.335	0.000
M07.5 Arthropathy in ulcerative colitis	0.000	0.335	0.664
M07.4 Arthropathy in Crohn's disease [regional enteritis]	0.000	0.335	0.664
M07.2 Psoriatic spondylitis	0.000	0.335	0.664
M07.1 Arthritis mutilans	0.000	0.335	0.664
M07.0 Distal interphalangeal psoriatic arthropathy	0.000	0.335	0.664
M23.82 Other internal derangements of knee (Posterior cruciate ligament or Posterior horn of medial meniscus)	0.000	0.337	0.663
M21.8 Other specified acquired deformities of limbs	0.000	0.337	0.663
M09 Juvenile arthritis in diseases classified elsewhere	0.000	0.338	0.662
H19.3 Keratitis and keratoconjunctivitis in other diseases classified elsewhere	0.000	0.338	0.662
D69.9 Haemorrhagic condition, unspecified	0.000	0.338	0.662
H18.2 Other corneal oedema	0.000	0.338	0.662
D80.9 Immunodeficiency with predominantly antibody defects, unspecified	0.000	0.339	0.661
N42.3 Dysplasia of prostate	0.660	0.340	0.000
M22.1 Recurrent subluxation of patella	0.000	0.342	0.658
D51.3 Other dietary vitamin B12 deficiency anaemia	0.000	0.342	0.658
D50.0 Iron deficiency anaemia secondary to blood loss (chronic)	0.000	0.343	0.657
M00.2 Other streptococcal arthritis and polyarthritis	0.000	0.343	0.656
M00.1 Pneumococcal arthritis and polyarthritis	0.000	0.343	0.656
N48.2 Other inflammatory disorders of penis	0.656	0.344	0.000
D69.1 Qualitative platelet defects	0.000	0.345	0.655
H15 Disorders of sclera	0.000	0.346	0.654
H34 Retinal vascular occlusions	0.000	0.346	0.654
D61.8 Other specified aplastic anaemias	0.000	0.346	0.654
D61.3 Idiopathic aplastic anaemia	0.000	0.346	0.654
D61.2 Aplastic anaemia due to other external agents	0.000	0.346	0.654
G70-G73 Diseases of myoneural junction and muscle	0.000	0.347	0.653
H18.5 Hereditary corneal dystrophies	0.000	0.348	0.652
D80.8 Other immunodeficiencies with predominantly antibody defects	0.000	0.348	0.651
D80.7 Transient hypogammaglobulinaemia of infancy	0.000	0.348	0.651
D80.5 Immunodeficiency with increased immunoglobulin M [IgM]	0.000	0.348	0.651
D80.0 Hereditary hypogammaglobulinaemia	0.000	0.348	0.651
H48 Disorders of optic [2nd] nerve and visual pathways in diseases classified elsewhere	0.000	0.349	0.651
H06.3 Other disorders of orbit in diseases classified elsewhere	0.000	0.350	0.650
H06.1 Parasitic infestation of orbit in diseases classified elsewhere	0.000	0.350	0.650
H06.0 Disorders of lachrymal system in diseases classified elsewhere	0.000	0.350	0.650
H17 Corneal scars and opacities	0.000	0.350	0.650
E05.8 Other thyrotoxicosis	0.000	0.353	0.647
H01 Other inflammation of eyelid	0.000	0.354	0.646
E51.2 Wernicke's encephalopathy	0.000	0.355	0.645
E10.4 With neurological complications	0.000	0.357	0.643
G31.0 Circumscribed brain atrophy	0.000	0.357	0.643
D67 Hereditary factor IX deficiency	0.000	0.358	0.642
G31.1 Senile degeneration of brain, not elsewhere classified	0.000	0.358	0.642
K90.3 Pancreatic steatorrhoea	0.000	0.359	0.641
K90.2 Blind loop syndrome, not elsewhere classified	0.000	0.359	0.641
K90.1 Tropical sprue	0.000	0.359	0.641
M00.97 Pyogenic arthritis, unspecified (Ankle and foot)	0.000	0.359	0.641
M02.38 Reiter's disease (Other)	0.000	0.360	0.640
M02.37 Reiter's disease (Ankle and foot)	0.000	0.360	0.640
M02.36 Reiter's disease (Lower leg)	0.000	0.360	0.640
M02.35 Reiter's disease (Pelvic region and thigh)	0.000	0.360	0.640
M02.34 Reiter's disease (Hand)	0.000	0.360	0.640
M02.33 Reiter's disease (Forearm)	0.000	0.360	0.640
M02.32 Reiter's disease (Upper arm)	0.000	0.360	0.640
M02.31 Reiter's disease (Shoulder region)	0.000	0.360	0.640
M02.30 Reiter's disease (Multiple sites)	0.000	0.360	0.640
M23.40 Loose body in knee-Mult sites	0.000	0.362	0.637
E14.4 With neurological complications	0.000	0.363	0.637
D80.4 Selective deficiency of immunoglobulin M [IgM]	0.000	0.363	0.637
M95-M99 Other disorders of the musculoskeletal system and connective tissue	0.000	0.363	0.637
E55.0 Rickets, active	0.000	0.363	0.637
L28 Lichen simplex chronicus and prurigo	0.000	0.365	0.635
M00.95 Pyogenic arthritis, unspecified (Pelvic region and thigh)	0.000	0.365	0.635
H19.2 Keratitis and keratoconjunctivitis in other infectious and parasitic diseases classified elsewhere	0.000	0.365	0.635
H16.3 Interstitial and deep keratitis	0.000	0.366	0.634
M00.90 Pyogenic arthritis, unspecified (Multiple sites)	0.000	0.367	0.633
E14.2 Withrenal complications	0.000	0.368	0.632
D86.2 Sarcoidosis of lung with sarcoidosis of lymph nodes	0.000	0.369	0.631
E54 Ascorbic acid deficiency	0.000	0.370	0.630
M22.9 Disorder of patella, unspecified	0.000	0.370	0.630
G30 Alzheimer's disease	0.000	0.370	0.630
E06 Thyroiditis	0.000	0.370	0.629
H18.7 Other corneal deformities	0.000	0.371	0.629
H11.3 Conjunctival haemorrhage	0.000	0.372	0.628
M00.91 Pyogenic arthritis, unspecified (Shoulder region)	0.000	0.372	0.628
H10 Conjunctivitis	0.000	0.374	0.626
H05.8 Other disorders of orbit	0.000	0.376	0.624
H16.8 Other keratitis	0.000	0.378	0.622
D50.8 Other iron deficiency anaemias	0.000	0.379	0.621
M11 Other crystal arthropathies	0.000	0.380	0.620
M00.99 Pyogenic arthritis, unspecified (Site unspecified)	0.000	0.381	0.619
M35.1 Other overlap syndromes	0.000	0.383	0.617
M02.96 Reactive arthropathy, unspecified (Lower leg)	0.000	0.383	0.617
M32.1 Systemic lupus erythematosus with organ or system involvement	0.000	0.383	0.617
E13 Other specified diabetes mellitus	0.000	0.383	0.616
G81.9 Hemiplegia, unspecified	0.000	0.384	0.616
M08 Juvenile arthritis	0.000	0.385	0.615
L57 Skin changes due to chronic exposure to nonionising radiation	0.000	0.386	0.614
M14 Arthropathies in other diseases classified elsewhere	0.000	0.386	0.614
M49 Spondylopathies in diseases classified elsewhere	0.000	0.386	0.613
H05.4 Enophthalmos	0.000	0.387	0.613
E14.5 With peripheral circulatory complications	0.000	0.388	0.611
M23.61 Other spontaneous disruption of ligament(s) of knee (Anterior cruciate ligament or Anterior horn of medial meniscus)	0.000	0.390	0.610
H21 Other disorders of iris and ciliary body	0.000	0.390	0.610
H16.4 Corneal neovascularisation	0.000	0.392	0.608
M02.99 Reactive arthropathy, unspecified (Site unspecified)	0.000	0.392	0.608
M02.98 Reactive arthropathy, unspecified (Other)	0.000	0.392	0.608
M02.97 Reactive arthropathy, unspecified (Ankle and foot)	0.000	0.392	0.608
M02.95 Reactive arthropathy, unspecified (Pelvic region and thigh)	0.000	0.392	0.608
M02.94 Reactive arthropathy, unspecified (Hand)	0.000	0.392	0.608
M02.93 Reactive arthropathy, unspecified (Forearm)	0.000	0.392	0.608
M02.92 Reactive arthropathy, unspecified (Upper arm)	0.000	0.392	0.608
M02.91 Reactive arthropathy, unspecified (Shoulder region)	0.000	0.392	0.608
M00.98 Pyogenic arthritis, unspecified (Other)	0.000	0.393	0.607
E14.7 With multiple complications	0.000	0.393	0.607
E14.0 With coma	0.000	0.393	0.607
G37.9 Demyelinating disease of central nervous system, unspecified	0.000	0.396	0.604
D66 Hereditary factor VIII deficiency	0.000	0.397	0.603
G10-G14 Systemic atrophies primarily affecting the central nervous system	0.000	0.398	0.602
D82 Immunodeficiency associated with other major defects	0.000	0.398	0.601
M23.86 Other internal derangements of knee (Other and unspecified lateral meniscus)	0.000	0.399	0.601
D52 Folate deficiency anaemia	0.000	0.400	0.600
E02 Subclinical iodine-deficiency hypothyroidism	0.000	0.400	0.600
H05.1 Chronic inflammatory disorders of orbit	0.000	0.402	0.598
M23.59 Chronic instability of knee (Unspecified ligament or Unspecified meniscus)	0.000	0.402	0.598
M23.84 Other internal derangements of knee (Lateral collateral ligament or Anterior horn of lateral meniscus)	0.000	0.402	0.598
H34.8 Other retinal vascular occlusions	0.000	0.404	0.596
L13 Other bullous disorders	0.000	0.404	0.596
M22.0 Recurrent dislocation of patella	0.000	0.405	0.594
H11.2 Conjunctival scars	0.000	0.406	0.594
H55-H59 Other disorders of eye and adnexa	0.000	0.406	0.594
M33.9 Dermatopolymyositis, unspecified	0.000	0.407	0.592
M33.0 Juvenile dermatomyositis	0.000	0.407	0.592
D80.6 Antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinaemia	0.000	0.407	0.592
M21.09 Valgus deformity, not elsewhere classified (Site unspecified)	0.000	0.408	0.592
M21.08 Valgus deformity, not elsewhere classified (Other)	0.000	0.408	0.592
M21.05 Valgus deformity, not elsewhere classified (Pelvic region and thigh)	0.000	0.408	0.592
M21.04 Valgus deformity, not elsewhere classified (Hand)	0.000	0.408	0.592
M21.03 Valgus deformity, not elsewhere classified (Forearm)	0.000	0.408	0.592
M21.02 Valgus deformity, not elsewhere classified (Upper arm)	0.000	0.408	0.592
M21.01 Valgus deformity, not elsewhere classified (Shoulder region)	0.000	0.408	0.592
M21.00 Valgus deformity, not elsewhere classified (Multiple sites)	0.000	0.408	0.592
M23.85 Other internal derangements of knee (Posterior horn of lateral meniscus)	0.000	0.408	0.592
D60 Acquired pure red cell aplasia [erythroblastopenia]	0.000	0.408	0.591
E10.6 With other specified complications	0.000	0.409	0.591
H50.0 Convergent concomitant strabismus	0.000	0.409	0.591
U82-U85 Resistance to antimicrobial and antineoplastic drugs	0.000	0.409	0.591
N48.1 Balanoposthitis	0.588	0.411	0.000
H05.5 Retained (old) foreign body following penetrating wound of orbit	0.000	0.413	0.587
H05.3 Deformity of orbit	0.000	0.413	0.587
H16.2 Keratoconjunctivitis	0.000	0.413	0.587
M21.6 Other acquired deformities of ankle and foot	0.000	0.413	0.587
D83.9 Common variable immunodeficiency, unspecified	0.000	0.413	0.587
L28.0 Lichen simplex chronicus	0.000	0.416	0.584
D64 Other anaemias	0.000	0.416	0.584
M21.7 Unequal limb length (acquired)	0.000	0.417	0.583
M23.51 Chronic instability of knee (Anterior cruciate ligament or Anterior horn of medial meniscus)	0.000	0.417	0.583
H02.2 Lagophthalmos	0.000	0.419	0.581
G32.8 Other specified degenerative disorders of nervous system in diseases classified elsewhere	0.000	0.419	0.581
L59 Other disorders of skin and subcutaneous tissue related to radiation	0.000	0.419	0.581
L50.1 Idiopathic urticaria	0.000	0.420	0.580
H19.8 Other disorders of sclera and cornea in diseases classified elsewhere	0.000	0.421	0.579
H19.0 Scleritis and episcleritis in diseases classified elsewhere	0.000	0.421	0.579
M12 Other specific arthropathies	0.000	0.421	0.579
G31.8 Other specified degenerative diseases of nervous system	0.000	0.421	0.579
K90.8 Other intestinal malabsorption	0.000	0.421	0.578
H50.4 Other and unspecified heterotropia	0.000	0.422	0.578
M63 Disorders of muscle in diseases classified elsewhere	0.000	0.422	0.577
M61 Calcification and ossification of muscle	0.000	0.422	0.577
M21.4 Flat foot [pes planus] (acquired)	0.000	0.423	0.577
G80 Infantile cerebral palsy	0.000	0.424	0.576
L50.0 Allergic urticaria	0.000	0.425	0.575
L54 Erythema in diseases classified elsewhere	0.000	0.425	0.574
E10.0 With coma	0.000	0.426	0.574
E10.8 With unspecified complications	0.000	0.427	0.573
H16.1 Other superficial keratitis without conjunctivitis	0.000	0.427	0.573
E03.0 Congenital hypothyroidism with diffuse goitre	0.000	0.428	0.572
H50.8 Other specified strabismus	0.000	0.428	0.572
M21.5 Acquired clawhand, clubhand, clawfoot and clubfoot	0.000	0.428	0.572
M62.5 Muscle wasting and atrophy, not elsewhere classified	0.000	0.429	0.571
G08 Intracranial and intraspinal phlebitis and thrombophlebitis	0.000	0.432	0.567
M23.16 Discoid meniscus (congenital) (Other and unspecified lateral meniscus)	0.000	0.434	0.566
L11 Other acantholytic disorders	0.000	0.434	0.566
L27 Dermatitis due to substances taken internally	0.000	0.434	0.566
M32.8 Other forms of systemic lupus erythematosus	0.000	0.434	0.566
G37.8 Other specified demyelinating diseases of central nervous system	0.000	0.434	0.566
M00.06 Staphylococcal arthritis and polyarthritis (Lower leg)	0.000	0.434	0.565
N51.2 Balanitis in diseases classified elsewhere	0.565	0.435	0.000
L21 Seborrhoeic dermatitis	0.000	0.435	0.565
E51.9 Thiamine deficiency, unspecified	0.000	0.437	0.563
E51.8 Other manifestations of thiamine deficiency	0.000	0.437	0.563
E51.1 Beriberi	0.000	0.437	0.563
H18.8 Other specified disorders of cornea	0.000	0.437	0.563
H03.8 Involvement of eyelid in other diseases classified elsewhere	0.000	0.439	0.561
H03.0 Parasitic infestation of eyelid in diseases classified elsewhere	0.000	0.439	0.561
G36.0 Neuromyelitis optica [Devic]	0.000	0.439	0.561
M21.1 Varus deformity, not elsewhere classified	0.000	0.439	0.561
M32.9 Systemic lupus erythematosus, unspecified	0.000	0.441	0.559
M32.0 Drug-induced systemic lupus erythematosus	0.000	0.441	0.559
H18.9 Disorder of cornea, unspecified	0.000	0.445	0.554
M33.2 Polymyositis	0.000	0.447	0.553
L56 Other acute skin changes due to ultraviolet radiation	0.000	0.447	0.553
M00.92 Pyogenic arthritis, unspecified (Upper arm)	0.000	0.447	0.553
H50.5 Heterophoria	0.000	0.448	0.552
M00.94 Pyogenic arthritis, unspecified (Hand)	0.000	0.448	0.551
E14.1 With ketoacidosis	0.000	0.451	0.549
H34.9 Retinal vascular occlusion, unspecified	0.000	0.451	0.549
D55-D59 Haemolytic anaemias	0.000	0.452	0.548
L50.6 Contact urticaria	0.000	0.452	0.548
L50.5 Cholinergic urticaria	0.000	0.452	0.548
L50.4 Vibratory urticaria	0.000	0.452	0.548
L50.3 Dermatographic urticaria	0.000	0.452	0.548
L50.2 Urticaria due to cold and heat	0.000	0.452	0.548
E56.1 Deficiency of vitamin K	0.000	0.453	0.547
M62.6 Muscle strain	0.000	0.454	0.546
M30 Polyarteritis nodosa and related conditions	0.000	0.454	0.545
L57.8 Other skin changes due to chronic exposure to nonionising radiation	0.000	0.455	0.545
D83.8 Other common variable immunodeficiencies	0.000	0.456	0.544
D83.2 Common variable immunodeficiency with autoantibodies to B- or T-cells	0.000	0.456	0.544
D83.1 Common variable immunodeficiency with predominant immunoregulatory T-cell disorders	0.000	0.456	0.544
D83.0 Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function	0.000	0.456	0.544
H21.8 Other specified disorders of iris and ciliary body	0.000	0.456	0.544
M23.93 Internal derangement of knee, unspecified (Medial collateral ligament or Other and unspecified medial meniscus)	0.000	0.456	0.544
M60 Myositis	0.000	0.457	0.543
P10-P15 Birth trauma	0.000	0.457	0.543
M21.9 Acquired deformity of limb, unspecified	0.000	0.457	0.543
H22.1 Iridocyclitis in other diseases classified elsewhere	0.000	0.458	0.542
M23.69 Other spontaneous disruption of ligament(s) of knee (Unspecified ligament or Unspecified meniscus)	0.000	0.459	0.541
M23.67 Other spontaneous disruption of ligament(s) of knee (Capsular ligament)	0.000	0.459	0.541
M23.66 Other spontaneous disruption of ligament(s) of knee-O/unsp	0.000	0.459	0.541
M23.65 Other spontaneous disruption of ligament(s) of knee-Pst hrn	0.000	0.459	0.541
M23.64 Other spontaneous disruption of ligament(s) of knee (Lateral collateral ligament or Anterior horn of lateral meniscus)	0.000	0.459	0.541
M23.63 Other spontaneous disruption of ligament(s) of knee (Medial collateral ligament or Other and unspecified medial meniscus)	0.000	0.459	0.541
M23.62 Other spontaneous disruption of ligament(s) of knee (Posterior cruciate ligament or Posterior horn of medial meniscus)	0.000	0.459	0.541
M23.60 Other spontaneous disruption of ligament(s) of knee (Multiple sites)	0.000	0.459	0.541
H13 Disorders of conjunctiva in diseases classified elsewhere	0.000	0.460	0.540
M23.57 Chronic instability of knee (Capsular ligament)	0.000	0.460	0.540
M23.56 Chronic instability of knee (Other and unspecified lateral meniscus)	0.000	0.460	0.540
M23.55 Chronic instability of knee (Posterior horn of lateral meniscus)	0.000	0.460	0.540

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations