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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs2523644
log Bayes Factor = 51.003
Chromosome 6   position 31,342,484  (GRCh37) Explore rs2523644 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E10.9 Without complications
0.000 0.000 1.000
K90.0 Coeliac disease
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
G35 Multiple sclerosis
1.000 0.000 0.000
E10-E14 Diabetes mellitus
0.000 0.000 1.000
E00-E07 Disorders of thyroid gland
0.000 0.000 1.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.000 1.000
E03.9 Hypothyroidism, unspecified
0.000 0.000 1.000
E83.1 Disorders of iron metabolism
1.000 0.000 0.000
E78.0 Pure hypercholesterolaemia
0.000 0.000 1.000
E03 Other hypothyroidism
0.000 0.000 1.000
M06.9 Rheumatoid arthritis, unspecified
0.000 0.000 1.000
E10.3 With ophthalmic complications
0.000 0.000 1.000
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.000 0.001 0.999
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.002 0.998
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)
0.000 0.002 0.998
E14 Unspecified diabetes mellitus
0.000 0.002 0.998
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)
0.000 0.002 0.998
E11 Non-insulin-dependent diabetes mellitus
0.000 0.003 0.997
E70-E90 Metabolic disorders
0.000 0.004 0.996
E05.9 Thyrotoxicosis, unspecified
0.000 0.005 0.995
E14.9 Without complications
0.000 0.008 0.992
E10.1 With ketoacidosis
0.000 0.012 0.988
E11.9 Without complications
0.000 0.013 0.987
M06.94 Rheumatoid arthritis, unspecified (Hand)
0.000 0.025 0.975
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.033 0.967
K51 Ulcerative colitis
0.949 0.051 0.000
K51.9 Ulcerative colitis, unspecified
0.945 0.055 0.000
E16 Other disorders of pancreatic internal secretion
0.000 0.056 0.944
E10.4 With neurological complications
0.000 0.057 0.943
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.062 0.938
I10 Essential (primary) hypertension
0.000 0.065 0.935
K51.3 Ulcerative (chronic) rectosigmoiditis
0.930 0.070 0.000
E11.1 With ketoacidosis
0.000 0.072 0.928
M06.96 Rheumatoid arthritis, unspecified (Lower leg)
0.000 0.075 0.925
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.000 0.079 0.921
E16.2 Hypoglycaemia, unspecified
0.000 0.083 0.917
K51.4 Pseudopolyposis of colon
0.905 0.095 0.000
E78.8 Other disorders of lipoprotein metabolism
0.000 0.104 0.896
M06.92 Rheumatoid arthritis, unspecified (Upper arm)
0.000 0.107 0.893
G35-G37 Demyelinating diseases of the central nervous system
0.891 0.109 0.000
E14.3 With ophthalmic complications
0.000 0.109 0.891
E11.0 With coma
0.000 0.110 0.890
K51.8 Other ulcerative colitis
0.888 0.112 0.000
E07 Other disorders of thyroid
0.000 0.112 0.888
M06.91 Rheumatoid arthritis, unspecified (Shoulder region)
0.000 0.128 0.872
E10.8 With unspecified complications
0.000 0.141 0.859
G37 Other demyelinating diseases of central nervous system
0.853 0.147 0.000
E74 Other disorders of carbohydrate metabolism
0.000 0.155 0.845
E10.2 With renal complications
0.000 0.159 0.841
E85 Amyloidosis
0.000 0.165 0.835
G37.9 Demyelinating disease of central nervous system, unspecified
0.823 0.177 0.000
K51.0 Ulcerative (chronic) enterocolitis
0.816 0.184 0.000
E07.9 Disorder of thyroid, unspecified
0.000 0.185 0.815
E78.1 Pure hyperglyceridaemia
0.000 0.187 0.813
M06.93 Rheumatoid arthritis, unspecified (Forearm)
0.000 0.189 0.811
K51.2 Ulcerative (chronic) proctitis
0.806 0.194 0.000
E78.2 Mixed hyperlipidaemia
0.000 0.196 0.804
E20-E35 Disorders of other endocrine glands
0.000 0.200 0.800
E16.1 Other hypoglycaemia
0.000 0.212 0.788
E78.5 Hyperlipidaemia, unspecified
0.000 0.213 0.787
K51.5 Mucosal proctocolitis
0.786 0.214 0.000
E10.0 With coma
0.000 0.235 0.765
E10.6 With other specified complications
0.000 0.239 0.761
M06.97 Rheumatoid arthritis, unspecified (Ankle and foot)
0.000 0.239 0.761
E14.4 With neurological complications
0.000 0.247 0.753
E10.5 With peripheral circulatory complications
0.000 0.251 0.749
E11.2 With renal complications
0.000 0.259 0.741
E05.8 Other thyrotoxicosis
0.000 0.259 0.740
E74.3 Other disorders of intestinal carbohydrate absorption
0.000 0.263 0.737
I10-I15 Hypertensive diseases
0.000 0.266 0.734
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.271 0.729
M06.98 Rheumatoid arthritis, unspecified (Other)
0.000 0.273 0.727
E11.3 With ophthalmic complications
0.000 0.281 0.719
E14.5 With peripheral circulatory complications
0.000 0.282 0.718
E10.7 With multiple complications
0.000 0.283 0.717
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.283 0.717
E00 Congenital iodine-deficiency syndrome
0.000 0.283 0.717
E12 Malnutrition-related diabetes mellitus
0.000 0.283 0.717
E03.5 Myxoedema coma
0.000 0.283 0.717
E03.4 Atrophy of thyroid (acquired)
0.000 0.283 0.717
E03.3 Postinfectious hypothyroidism
0.000 0.283 0.717
E03.1 Congenital hypothyroidism without goitre
0.000 0.283 0.717
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.283 0.717
E78.6 Lipoprotein deficiency
0.000 0.284 0.716
E78.3 Hyperchylomicronaemia
0.000 0.284 0.716
E05.5 Thyroid crisis or storm
0.000 0.284 0.716
E05.4 Thyrotoxicosis factitia
0.000 0.284 0.716
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.284 0.716
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.284 0.716
E14.8 With unspecified complications
0.000 0.285 0.715
E14.7 With multiple complications
0.000 0.285 0.715
E14.6 With other specified complications
0.000 0.285 0.715
E14.2 Withrenal complications
0.000 0.285 0.715
E14.1 With ketoacidosis
0.000 0.285 0.715
E14.0 With coma
0.000 0.285 0.715
E11.7 With multiple complications
0.000 0.285 0.714
E77 Disorders of glycoprotein metabolism
0.000 0.286 0.714
E76 Disorders of glycosaminoglycan metabolism
0.000 0.286 0.714
E72 Other disorders of amino-acid metabolism
0.000 0.286 0.714
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.000 0.286 0.714
E70 Disorders of aromatic amino-acid metabolism
0.000 0.286 0.714
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.000 0.286 0.714
E28 Ovarian dysfunction
0.000 0.296 0.704
E84 Cystic fibrosis
0.000 0.296 0.704
E79 Disorders of purine and pyrimidine metabolism
0.000 0.297 0.703
E13 Other specified diabetes mellitus
0.000 0.299 0.701
E78.4 Other hyperlipidaemia
0.000 0.300 0.700
E11.5 With peripheral circulatory complications
0.000 0.300 0.700
E85.9 Amyloidosis, unspecified
0.000 0.303 0.697
E15 Nondiabetic hypoglycaemic coma
0.000 0.306 0.694
G37.8 Other specified demyelinating diseases of central nervous system
0.693 0.307 0.000
E06 Thyroiditis
0.000 0.316 0.684
E03.8 Other specified hypothyroidism
0.000 0.317 0.683
I12 Hypertensive renal disease
0.000 0.319 0.681
E40-E46 Malnutrition
0.000 0.320 0.680
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.323 0.677
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.323 0.677
E16.4 Abnormal secretion of gastrin
0.000 0.323 0.677
E16.3 Increased secretion of glucagon
0.000 0.323 0.677
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.000 0.325 0.675
E23 Hypofunction and other disorders of pituitary gland
0.000 0.327 0.673
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.333 0.667
M45.X9 Ankylosing spondylitis (Site unspecified)
0.000 0.337 0.663
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.339 0.661
E11.8 With unspecified complications
0.000 0.339 0.661
E85.4 Organ-limited amyloidosis
0.000 0.342 0.658
E73 Lactose intolerance
0.000 0.346 0.654
E28.2 Polycystic ovarian syndrome
0.000 0.346 0.654
K51.1 Ulcerative (chronic) ileocolitis
0.640 0.360 0.000
G36 Other acute disseminated demyelination
0.639 0.361 0.000
E07.1 Dyshormogenetic goitre
0.000 0.364 0.636
E07.0 Hypersecretion of calcitonin
0.000 0.364 0.636
E11.6 With other specified complications
0.000 0.364 0.636
E29 Testicular dysfunction
0.000 0.364 0.636
I12.9 Hypertensive renal disease without renal failure
0.000 0.366 0.634
E24 Cushing's syndrome
0.000 0.373 0.627
G37.5 Concentric sclerosis [Balo]
0.611 0.388 0.000
G37.4 Subacute necrotising myelitis
0.611 0.388 0.000
G37.2 Central pontine myelinolysis
0.611 0.388 0.000
G37.1 Central demyelination of corpus callosum
0.611 0.388 0.000
G37.0 Diffuse sclerosis
0.611 0.388 0.000
E07.8 Other specified disorders of thyroid
0.000 0.389 0.610
E74.9 Disorder of carbohydrate metabolism, unspecified
0.000 0.394 0.606
E74.8 Other specified disorders of carbohydrate metabolism
0.000 0.394 0.606
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
0.000 0.394 0.606
E74.2 Disorders of galactose metabolism
0.000 0.394 0.606
E74.1 Disorders of fructose metabolism
0.000 0.394 0.606
E74.0 Glycogen storage disease
0.000 0.394 0.606
M06 Other rheumatoid arthritis
0.000 0.399 0.601
E85.8 Other amyloidosis
0.000 0.402 0.598
E85.2 Heredofamilial amyloidosis, unspecified
0.000 0.402 0.598
E85.1 Neuropathic heredofamilial amyloidosis
0.000 0.402 0.598
E85.0 Nonneuropathic heredofamilial amyloidosis
0.000 0.402 0.598
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.000 0.410 0.590
E22 Hyperfunction of pituitary gland
0.000 0.416 0.584
E83 Disorders of mineral metabolism
0.297 0.418 0.285
E50-E64 Other nutritional deficiencies
0.000 0.420 0.579
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.426 0.574
E32 Diseases of thymus
0.000 0.426 0.574
E31 Polyglandular dysfunction
0.000 0.426 0.574
E30 Disorders of puberty, not elsewhere classified
0.000 0.426 0.574
E25 Adrenogenital disorders
0.000 0.426 0.574
E23.7 Disorder of pituitary gland, unspecified
0.000 0.427 0.573
I15 Secondary hypertension
0.000 0.430 0.570
E85.3 Secondary systemic amyloidosis
0.000 0.430 0.569
E26 Hyperaldosteronism
0.000 0.435 0.564
M06.3 Rheumatoid nodule
0.000 0.442 0.558
E78.9 Disorder of lipoprotein metabolism, unspecified
0.000 0.448 0.552
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.000 0.454 0.546
M45 Ankylosing spondylitis
0.000 0.456 0.544
J45.9 Asthma, unspecified
0.000 0.457 0.543
I13 Hypertensive heart and renal disease
0.000 0.473 0.526
I12.0 Hypertensive renal disease with renal failure
0.000 0.475 0.525
E80 Disorders of porphyrin and bilirubin metabolism
0.000 0.479 0.521
G37.3 Acute transverse myelitis in demyelinating disease of central nervous system
0.518 0.482 0.000
E29.1 Testicular hypofunction
0.000 0.482 0.518
I11 Hypertensive heart disease
0.000 0.485 0.515
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.000 0.486 0.514
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.000 0.486 0.514
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.000 0.486 0.514
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.000 0.486 0.514
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.486 0.514
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.000 0.486 0.514
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.000 0.486 0.514
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.000 0.486 0.514
E12.9 Without complications
0.000 0.486 0.514
E12.8 With unspecified complications
0.000 0.486 0.514
E12.7 With multiple complications
0.000 0.486 0.514
E12.6 With other specified complications
0.000 0.486 0.514
E12.5 With peripheral circulatory complications
0.000 0.486 0.514
E12.4 With neurological complications
0.000 0.486 0.514
E12.3 With ophthalmic complications
0.000 0.486 0.514
E12.2 With renal complications
0.000 0.486 0.514
E12.1 With ketoacidosis
0.000 0.486 0.514
E12.0 With coma
0.000 0.486 0.514
E23.6 Other disorders of pituitary gland
0.000 0.486 0.514
E89.3 Postprocedural hypopituitarism
0.000 0.487 0.513
E70.9 Disorder of aromatic amino-acid metabolism, unspecified
0.000 0.488 0.512
E70.8 Other disorders of aromatic amino-acid metabolism
0.000 0.488 0.512
E70.3 Albinism
0.000 0.488 0.512
E70.2 Disorders of tyrosine metabolism
0.000 0.488 0.512
E70.1 Other hyperphenylalaninaemias
0.000 0.488 0.512
E70.0 Classical phenylketonuria
0.000 0.488 0.512
E71.3 Disorders of fatty-acid metabolism
0.000 0.488 0.512
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified
0.000 0.488 0.512
E71.1 Other disorders of branched-chain amino-acid metabolism
0.000 0.488 0.512
E71.0 Maple-syrup-urine disease
0.000 0.488 0.512
E72.9 Disorder of amino-acid metabolism, unspecified
0.000 0.488 0.512
E72.8 Other specified disorders of amino-acid metabolism
0.000 0.488 0.512
E72.5 Disorders of glycine metabolism
0.000 0.488 0.512
E72.4 Disorders of ornithine metabolism
0.000 0.488 0.512
E72.3 Disorders of lysine and hydroxylysine metabolism
0.000 0.488 0.512
E72.2 Disorders of urea cycle metabolism
0.000 0.488 0.512
E72.1 Disorders of sulphur-bearing amino-acid metabolism
0.000 0.488 0.512
E72.0 Disorders of amino-acid transport
0.000 0.488 0.512
E76.9 Disorder of glucosaminoglycan metabolism, unspecified
0.000 0.488 0.512
E76.8 Other disorders of glucosaminoglycan metabolism
0.000 0.488 0.512
E76.3 Mucopolysaccharidosis, unspecified
0.000 0.488 0.512
E76.2 Other mucopolysaccharidoses
0.000 0.488 0.512
E76.1 Mucopolysaccharidosis, type II
0.000 0.488 0.512
E76.0 Mucopolysaccharidosis, type I
0.000 0.488 0.512
E77.9 Disorder of glycoprotein metabolism, unspecified
0.000 0.488 0.512
E77.8 Other disorders of glycoprotein metabolism
0.000 0.488 0.512
E77.1 Defects in glycoprotein degradation
0.000 0.488 0.512
E77.0 Defects in posttranslational modification of lysosomal enzymes
0.000 0.488 0.512
E23.2 Diabetes insipidus
0.000 0.491 0.509
E28.9 Ovarian dysfunction, unspecified
0.000 0.495 0.505
E28.8 Other ovarian dysfunction
0.000 0.495 0.505
E28.1 Androgen excess
0.000 0.495 0.505
E28.0 Oestrogen excess
0.000 0.495 0.505
E84.8 Cystic fibrosis with other manifestations
0.000 0.495 0.504
E84.1 Cystic fibrosis with intestinal manifestations
0.000 0.495 0.504
E84.0 Cystic fibrosis with pulmonary manifestations
0.000 0.495 0.504
E79.9 Disorder of purine and pyrimidine metabolism, unspecified
0.000 0.496 0.504
E79.8 Other disorders of purine and pyrimidine metabolism
0.000 0.496 0.504
E79.1 Lesch-Nyhan syndrome
0.000 0.496 0.504
E13.8 With unspecified complications
0.000 0.497 0.502
E13.7 With multiple complications
0.000 0.497 0.502
E13.6 With other specified complications
0.000 0.497 0.502
E13.5 With peripheral circulatory complications
0.000 0.497 0.502
E13.4 With neurological complications
0.000 0.497 0.502
E13.3 With ophthalmic complications
0.000 0.497 0.502
E13.2 With renal complications
0.000 0.497 0.502
E13.1 With ketoacidosis
0.000 0.497 0.502
E13.0 With coma
0.000 0.497 0.502
E24.9 Cushing's syndrome, unspecified
0.000 0.498 0.502
M06.34 Rheumatoid nodule (Hand)
0.000 0.499 0.501
E61 Deficiency of other nutrient elements
0.000 0.500 0.500
M45.X0 Ankylosing spondylitis (Multiple sites in spine)
0.000 0.504 0.496
E84.9 Cystic fibrosis, unspecified
0.000 0.505 0.494
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
0.000 0.506 0.493
E06.5 Other chronic thyroiditis
0.000 0.510 0.490
E06.4 Drug-induced thyroiditis
0.000 0.510 0.490
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.510 0.490
E06.1 Subacute thyroiditis
0.000 0.510 0.490
E06.0 Acute thyroiditis
0.000 0.510 0.490
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.512 0.487
E45 Retarded development following protein-energy malnutrition
0.000 0.512 0.487
E43 Unspecified severe protein-energy malnutrition
0.000 0.512 0.487
E42 Marasmic kwashiorkor
0.000 0.512 0.487
E41 Nutritional marasmus
0.000 0.512 0.487
E40 Kwashiorkor
0.000 0.512 0.487
E13.9 Without complications
0.000 0.513 0.486
E75.6 Lipid storage disorder, unspecified
0.000 0.516 0.484
E75.4 Neuronal ceroid lipofuscinosis
0.000 0.516 0.484
E75.3 Sphingolipidosis, unspecified
0.000 0.516 0.484
E75.2 Other sphingolipidosis
0.000 0.516 0.484
E75.1 Other gangliosidosis
0.000 0.516 0.484
E75.0 GM2 gangliosidosis
0.000 0.516 0.484
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.000 0.517 0.483
E23.1 Drug-induced hypopituitarism
0.000 0.517 0.483
E34 Other endocrine disorders
0.000 0.519 0.481
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.520 0.479
E06.3 Autoimmune thyroiditis
0.000 0.524 0.476
E06.9 Thyroiditis, unspecified
0.000 0.527 0.473
E73.8 Other lactose intolerance
0.000 0.531 0.469
E73.1 Secondary lactase deficiency
0.000 0.531 0.469
E73.0 Congenital lactase deficiency
0.000 0.531 0.469
E65-E68 Obesity and other hyperalimentation
0.000 0.534 0.466
E21.3 Hyperparathyroidism, unspecified
0.000 0.535 0.465
E11.4 With neurological complications
0.000 0.539 0.461
M45.X2 Ankylosing spondylitis (Cervical region)
0.000 0.539 0.461
G36.9 Acute disseminated demyelination, unspecified
0.458 0.542 0.000
G36.8 Other specified acute disseminated demyelination
0.458 0.542 0.000
G36.1 Acute and subacute haemorrhagic leukoencephalitis [Hurst]
0.458 0.542 0.000
G36.0 Neuromyelitis optica [Devic]
0.458 0.542 0.000
E29.9 Testicular dysfunction, unspecified
0.000 0.544 0.456
E29.8 Other testicular dysfunction
0.000 0.544 0.456
E29.0 Testicular hyperfunction
0.000 0.544 0.456
E89.6 Postprocedural adrenocortical(-medullary) hypofunction
0.000 0.544 0.456
I15.1 Hypertension secondary to other renal disorders
0.000 0.548 0.452
E61.1 Iron deficiency
0.000 0.549 0.451
E46 Unspecified protein-energy malnutrition
0.000 0.550 0.450
E20 Hypoparathyroidism
0.000 0.550 0.449
E24.8 Other Cushing's syndrome
0.000 0.550 0.449
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.000 0.550 0.449
E24.3 Ectopic ACTH syndrome
0.000 0.550 0.449
E24.2 Drug-induced Cushing's syndrome
0.000 0.550 0.449
E24.1 Nelson's syndrome
0.000 0.550 0.449
E24.0 Pituitary-dependent Cushing's disease
0.000 0.550 0.449
M06.32 Rheumatoid nodule (Upper arm)
0.000 0.552 0.448
E75.5 Other lipid storage disorders
0.000 0.554 0.446
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.000 0.562 0.438
M06.37 Rheumatoid nodule (Ankle and foot)
0.000 0.566 0.434
E22.0 Acromegaly and pituitary gigantism
0.000 0.567 0.433
E23.0 Hypopituitarism
0.000 0.568 0.432
E28.3 Primary ovarian failure
0.000 0.568 0.431
M06.8 Other specified rheumatoid arthritis
0.000 0.569 0.431
M06.2 Rheumatoid bursitis
0.000 0.569 0.431
M06.1 Adult-onset Still's disease
0.000 0.569 0.431
E89.4 Postprocedural ovarian failure
0.000 0.577 0.423
E89.9 Postprocedural endocrine and metabolic disorder, unspecified
0.000 0.577 0.423
E89.8 Other postprocedural endocrine and metabolic disorders
0.000 0.577 0.423
E89.5 Postprocedural testicular hypofunction
0.000 0.577 0.423
E89.1 Postprocedural hypoinsulinaemia
0.000 0.577 0.423
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.581 0.419
E22.8 Other hyperfunction of pituitary gland
0.000 0.581 0.419
E83.9 Disorder of mineral metabolism, unspecified
0.213 0.582 0.205
E83.8 Other disorders of mineral metabolism
0.213 0.582 0.205
E83.2 Disorders of zinc metabolism
0.213 0.582 0.205
E83.0 Disorders of copper metabolism
0.213 0.582 0.205
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.584 0.415
E63 Other nutritional deficiencies
0.000 0.584 0.415
E56 Other vitamin deficiencies
0.000 0.584 0.415
E51 Thiamine deficiency
0.000 0.584 0.415
E50 Vitamin A deficiency
0.000 0.584 0.415
E60 Dietary zinc deficiency
0.000 0.584 0.415
E59 Dietary selenium deficiency
0.000 0.584 0.415
E58 Dietary calcium deficiency
0.000 0.584 0.415
E54 Ascorbic acid deficiency
0.000 0.584 0.415
E52 Niacin deficiency [pellagra]
0.000 0.584 0.415
E25.9 Adrenogenital disorder, unspecified
0.000 0.588 0.411
E25.8 Other adrenogenital disorders
0.000 0.588 0.411
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.000 0.588 0.411
E30.9 Disorder of puberty, unspecified
0.000 0.588 0.411
E30.8 Other disorders of puberty
0.000 0.588 0.411
E30.1 Precocious puberty
0.000 0.588 0.411
E30.0 Delayed puberty
0.000 0.588 0.411
E31.9 Polyglandular dysfunction, unspecified
0.000 0.588 0.411
E31.8 Other polyglandular dysfunction
0.000 0.588 0.411
E31.1 Polyglandular hyperfunction
0.000 0.588 0.411
E31.0 Autoimmune polyglandular failure
0.000 0.588 0.411
E32.9 Disease of thymus, unspecified
0.000 0.588 0.411
E32.8 Other diseases of thymus
0.000 0.588 0.411
E32.1 Abscess of thymus
0.000 0.588 0.411
E32.0 Persistent hyperplasia of thymus
0.000 0.588 0.411
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.588 0.411
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.588 0.411
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.588 0.411
E73.9 Lactose intolerance, unspecified
0.000 0.591 0.409
I15.9 Seconday hypertension, unspecified
0.000 0.591 0.409
I15.8 Other secondary hypertension
0.000 0.591 0.409
I15.2 Hypertension secondary to endocrine disorders
0.000 0.591 0.409
I15.0 Renovascular hypertension
0.000 0.591 0.409
E26.9 Hyperaldosteronism, unspecified
0.000 0.595 0.405
E26.8 Other hyperaldosteronism
0.000 0.595 0.405
E26.1 Secondary hyperaldosteronism
0.000 0.595 0.405
M06.39 Rheumatoid nodule (Site unspecified)
0.000 0.600 0.400
M06.38 Rheumatoid nodule (Other)
0.000 0.600 0.400
M06.36 Rheumatoid nodule (Lower leg)
0.000 0.600 0.400
M06.35 Rheumatoid nodule (Pelvic region and thigh)
0.000 0.600 0.400
M06.33 Rheumatoid nodule (Forearm)
0.000 0.600 0.400
M06.31 Rheumatoid nodule (Shoulder region)
0.000 0.600 0.400
M06.30 Rheumatoid nodule (Multiple sites)
0.000 0.600 0.400
E26.0 Primary hyperaldosteronism
0.000 0.604 0.395
E22.1 Hyperprolactinaemia
0.000 0.608 0.392
E21.5 Disorder of parathyroid gland, unspecified
0.000 0.609 0.391
E21.4 Other specified disorders of parathyroid gland
0.000 0.609 0.391
E21.2 Other hyperparathyroidism
0.000 0.609 0.391
M45.X8 Ankylosing spondylitis (Sacral and sacrococcygeal region)
0.000 0.610 0.390
M45.X7 Ankylosing spondylitis (Lumbosacral region)
0.000 0.610 0.390
M45.X6 Ankylosing spondylitis (Lumbar region)
0.000 0.610 0.390
M45.X5 Ankylosing spondylitis (Thoracolumbar region)
0.000 0.610 0.390
M45.X4 Ankylosing spondylitis (Thoracic region)
0.000 0.610 0.390
M45.X3 Ankylosing spondylitis (Cervicothoracic region)
0.000 0.610 0.390
M45.X1 Ankylosing spondylitis (Occipito-atlanto-axial region)
0.000 0.610 0.390
I11.0 Hypertensive heart disease with (congestive) heart failure
0.000 0.617 0.383
M06.4 Inflammatory polyarthropathy
0.000 0.618 0.382
Chapter VI Diseases of the nervous system
0.378 0.622 0.000
I13.9 Hypertensive heart and renal disease, unspecified
0.000 0.622 0.378
I13.2 Hypertensive heart and renal disease with both (congestive) heart failure and renal failure
0.000 0.622 0.378
I13.1 Hypertensive heart and renal disease with renal failure
0.000 0.622 0.378
I13.0 Hypertensive heart and renal disease with (congestive) heart failure
0.000 0.622 0.378
E80.7 Disorder of bilirubin metabolism, unspecified
0.000 0.626 0.374
E80.5 Crigler-Najjar syndrome
0.000 0.626 0.374
E80.3 Defects of catalase and peroxydase
0.000 0.626 0.374
E80.2 Other porphyria
0.000 0.626 0.374
E80.0 Hereditary erythropoietic porphyria
0.000 0.626 0.374
E80.6 Other disorders of bilirubin metabolism
0.000 0.633 0.367
E88 Other metabolic disorders
0.000 0.636 0.363
E61.9 Deficiency of nutrient element, unspecified
0.000 0.641 0.358
E61.8 Deficiency of other specified nutrient elements
0.000 0.641 0.358
E61.7 Deficiency of multiple nutrient elements
0.000 0.641 0.358
E61.6 Vanadium deficiency
0.000 0.641 0.358
E61.5 Molybdenum deficiency
0.000 0.641 0.358
E61.4 Chromium deficiency
0.000 0.641 0.358
E61.3 Manganese deficiency
0.000 0.641 0.358
E61.0 Copper deficiency
0.000 0.641 0.358
E27 Other disorders of adrenal gland
0.000 0.642 0.358
E80.1 Porphyria cutanea tarda
0.000 0.642 0.357
G30-G32 Other degenerative diseases of the nervous system
0.358 0.642 0.000
G20-G26 Extrapyramidal and movement disorders
0.355 0.645 0.000
G20 Parkinson's disease
0.350 0.650 0.000
E83.3 Disorders of phosphorus metabolism
0.206 0.650 0.144
E44.1 Mild protein-energy malnutrition
0.000 0.650 0.350
E44.0 Moderate protein-energy malnutrition
0.000 0.650 0.350
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.000 0.653 0.346
E34.5 Androgen resistance syndrome
0.000 0.655 0.345
E34.4 Constitutional tall stature
0.000 0.655 0.345
E34.3 Short stature, not elsewhere classified
0.000 0.655 0.345
E34.2 Ectopic hormone secretion, not elsewhere classified
0.000 0.655 0.345
E34.1 Other hypersecretion of intestinal hormones
0.000 0.655 0.345
G31 Other degenerative diseases of nervous system, not elsewhere classified
0.343 0.656 0.000
G00-G09 Inflammatory diseases of the central nervous system
0.342 0.658 0.000
I11.9 Hypertensive heart disease without (congestive) heart failure
0.000 0.659 0.341
G31.9 Degenerative disease of nervous system, unspecified
0.340 0.660 0.000
E65 Localised adiposity
0.000 0.666 0.334
E67 Other hyperalimentation
0.000 0.666 0.334
E68 Sequelae of hyperalimentation
0.000 0.666 0.334
E61.2 Magnesium deficiency
0.000 0.667 0.333
E34.8 Other specified endocrine disorders
0.000 0.674 0.325
E34.0 Carcinoid syndrome
0.000 0.677 0.323
E20.8 Other hypoparathyroidism
0.000 0.678 0.322
E20.1 Pseudohypoparathyroidism
0.000 0.678 0.322
E20.0 Idiopathic hypoparathyroidism
0.000 0.678 0.322
M06.0 Seronegative rheumatoid arthritis
0.000 0.685 0.315
M06.19 Adult-onset Still's disease (Site unspecified)
0.000 0.691 0.309
M06.18 Adult-onset Still's disease (Other)
0.000 0.691 0.309
M06.17 Adult-onset Still's disease (Ankle and foot)
0.000 0.691 0.309
M06.16 Adult-onset Still's disease (Lower leg)
0.000 0.691 0.309
M06.15 Adult-onset Still's disease (Pelvic region and thigh)
0.000 0.691 0.309
M06.14 Adult-onset Still's disease (Hand)
0.000 0.691 0.309
M06.13 Adult-onset Still's disease (Forearm)
0.000 0.691 0.309
M06.12 Adult-onset Still's disease (Upper arm)
0.000 0.691 0.309
M06.11 Adult-onset Still's disease (Shoulder region)
0.000 0.691 0.309
M06.10 Adult-onset Still's disease (Multiple sites)
0.000 0.691 0.309
M06.29 Rheumatoid bursitis (Site unspecified)
0.000 0.691 0.309
M06.28 Rheumatoid bursitis (Other)
0.000 0.691 0.309
M06.27 Rheumatoid bursitis (Ankle and foot)
0.000 0.691 0.309
M06.26 Rheumatoid bursitis (Lower leg)
0.000 0.691 0.309
M06.25 Rheumatoid bursitis (Pelvic region and thigh)
0.000 0.691 0.309
M06.24 Rheumatoid bursitis (Hand)
0.000 0.691 0.309
M06.23 Rheumatoid bursitis (Forearm)
0.000 0.691 0.309
M06.22 Rheumatoid bursitis (Upper arm)
0.000 0.691 0.309
M06.21 Rheumatoid bursitis (Shoulder region)
0.000 0.691 0.309
M06.20 Rheumatoid bursitis (Multiple sites)
0.000 0.691 0.309
M06.89 Other specified rheumatoid arthritis (Site unspecified)
0.000 0.691 0.309
M06.88 Other specified rheumatoid arthritis (Other)
0.000 0.691 0.309
M06.87 Other specified rheumatoid arthritis (Ankle and foot)
0.000 0.691 0.309
M06.86 Other specified rheumatoid arthritis (Lower leg)
0.000 0.691 0.309
M06.85 Other specified rheumatoid arthritis (Pelvic region and thigh)
0.000 0.691 0.309
M06.84 Other specified rheumatoid arthritis (Hand)
0.000 0.691 0.309
M06.83 Other specified rheumatoid arthritis (Forearm)
0.000 0.691 0.309
M06.82 Other specified rheumatoid arthritis (Upper arm)
0.000 0.691 0.309
M06.81 Other specified rheumatoid arthritis (Shoulder region)
0.000 0.691 0.309
M06.80 Other specified rheumatoid arthritis (Multiple sites)
0.000 0.691 0.309
E34.9 Endocrine disorder, unspecified
0.000 0.691 0.309
G80-G83 Cerebral palsy and other paralytic syndromes
0.308 0.691 0.000
E27.9 Disorder of adrenal gland, unspecified
0.000 0.693 0.307
E55 Vitamin D deficiency
0.000 0.695 0.305
E83.4 Disorders of magnesium metabolism
0.067 0.700 0.233
E50.9 Vitamin A deficiency, unspecified
0.000 0.702 0.298
E50.8 Other manifestations of vitamin A deficiency
0.000 0.702 0.298
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.702 0.298
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.702 0.298
E50.5 Vitamin A deficiency with night blindness
0.000 0.702 0.298
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.702 0.298
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.702 0.298
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.702 0.298
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.702 0.298
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.702 0.298
E51.9 Thiamine deficiency, unspecified
0.000 0.702 0.298
E51.8 Other manifestations of thiamine deficiency
0.000 0.702 0.298
E51.2 Wernicke's encephalopathy
0.000 0.702 0.298
E51.1 Beriberi
0.000 0.702 0.298
E56.9 Vitamin deficiency, unspecified
0.000 0.702 0.298
E56.8 Deficiency of other vitamins
0.000 0.702 0.298
E56.1 Deficiency of vitamin K
0.000 0.702 0.298
E56.0 Deficiency of vitamin E
0.000 0.702 0.298
E63.9 Nutritional deficiency, unspecified
0.000 0.702 0.298
E63.8 Other specified nutritional deficiencies
0.000 0.702 0.298
E63.1 Imbalance of constituents of food intake
0.000 0.702 0.298
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.702 0.298
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.702 0.298
E64.8 Sequelae of other nutritional deficiencies
0.000 0.702 0.298
E64.3 Sequelae of rickets
0.000 0.702 0.298
E64.2 Sequelae of vitamin C deficiency
0.000 0.702 0.298
E64.1 Sequelae of vitamin A deficiency
0.000 0.702 0.298
E64.0 Sequelae of protein-energy malnutrition
0.000 0.702 0.298
E89.2 Postprocedural hypoparathyroidism
0.000 0.708 0.292
G10-G14 Systemic atrophies primarily affecting the central nervous system
0.284 0.716 0.000
G09 Sequelae of inflammatory diseases of central nervous system
0.281 0.719 0.000
G31.2 Degeneration of nervous system due to alcohol
0.279 0.721 0.000
G05 Encephalitis, myelitis and encephalomyelitis in diseases classified elsewhere
0.279 0.721 0.000
E21.0 Primary hyperparathyroidism
0.000 0.724 0.276
M06.48 Inflammatory polyarthropathy (Other)
0.000 0.726 0.274
M06.47 Inflammatory polyarthropathy (Ankle and foot)
0.000 0.726 0.274
M06.46 Inflammatory polyarthropathy (Lower leg)
0.000 0.726 0.274
M06.45 Inflammatory polyarthropathy (Pelvic region and thigh)
0.000 0.726 0.274

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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