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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs2523857
log Bayes Factor = 77.1253
Chromosome 6   position 31,021,504  (GRCh37) Explore rs2523857 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E03.9 Hypothyroidism, unspecified
0.000 0.000 1.000
K90.0 Coeliac disease
0.000 0.000 1.000
L40.9 Psoriasis, unspecified
0.000 0.000 1.000
E05.9 Thyrotoxicosis, unspecified
0.000 0.000 1.000
L40.5 Arthropathic psoriasis
0.000 0.000 1.000
L40 Psoriasis
0.000 0.000 1.000
E03 Other hypothyroidism
0.000 0.000 1.000
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.001 0.999
E00-E07 Disorders of thyroid gland
0.000 0.001 0.999
E07 Other disorders of thyroid
0.000 0.072 0.928
C61 Malignant neoplasm of prostate
0.917 0.083 0.000
E83.1 Disorders of iron metabolism
0.911 0.089 0.000
E07.9 Disorder of thyroid, unspecified
0.000 0.111 0.889
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.144 0.856
E03.8 Other specified hypothyroidism
0.000 0.165 0.835
L40.0 Psoriasis vulgaris
0.000 0.184 0.816
L40.1 Generalised pustular psoriasis
0.000 0.198 0.802
L40.4 Guttate psoriasis
0.000 0.234 0.766
C83.3 Large cell (diffuse)
0.000 0.239 0.761
L40.8 Other psoriasis
0.000 0.257 0.743
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.275 0.725
L40.2 Acrodermatitis continua
0.000 0.283 0.717
E03.5 Myxoedema coma
0.000 0.283 0.717
E03.4 Atrophy of thyroid (acquired)
0.000 0.283 0.717
E03.3 Postinfectious hypothyroidism
0.000 0.283 0.717
E05.5 Thyroid crisis or storm
0.000 0.284 0.716
E05.4 Thyrotoxicosis factitia
0.000 0.284 0.716
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.284 0.716
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.284 0.716
E00 Congenital iodine-deficiency syndrome
0.000 0.284 0.716
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.286 0.714
C83 Diffuse non-Hodgkin's lymphoma
0.000 0.287 0.713
C81-C96 Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissue
0.000 0.304 0.696
C85 Other and unspecified types of non-Hodgkin's lymphoma
0.000 0.306 0.694
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.310 0.690
E78.0 Pure hypercholesterolaemia
0.000 0.315 0.685
C82 Follicular [nodular] non-Hodgkin's lymphoma
0.000 0.315 0.685
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.000 0.316 0.684
C85.1 B-cell lymphoma, unspecified
0.000 0.321 0.679
C85.9 Non-Hodgkin's lymphoma, unspecified type
0.000 0.333 0.667
E07.1 Dyshormogenetic goitre
0.000 0.335 0.665
E07.0 Hypersecretion of calcitonin
0.000 0.335 0.665
E70-E90 Metabolic disorders
0.001 0.335 0.664
E10-E14 Diabetes mellitus
0.000 0.338 0.662
C82.9 Follicular non-Hodgkin's lymphoma, unspecified
0.000 0.355 0.645
K90 Intestinal malabsorption
0.000 0.356 0.644
C81 Hodgkin's disease
0.000 0.356 0.644
E78.8 Other disorders of lipoprotein metabolism
0.000 0.357 0.643
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.358 0.642
E78.5 Hyperlipidaemia, unspecified
0.000 0.365 0.635
E05.8 Other thyrotoxicosis
0.000 0.383 0.617
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.385 0.615
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.386 0.613
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.000 0.387 0.613
E40-E46 Malnutrition
0.000 0.390 0.610
E10 Insulin-dependent diabetes mellitus
0.000 0.405 0.595
C83.7 Burkitt's tumour
0.000 0.408 0.592
E07.8 Other specified disorders of thyroid
0.000 0.414 0.586
C82.2 Large cell, follicular
0.000 0.415 0.585
E03.1 Congenital hypothyroidism without goitre
0.000 0.415 0.584
E20-E35 Disorders of other endocrine glands
0.000 0.418 0.582
E89.0 Postprocedural hypothyroidism
0.000 0.424 0.576
C82.7 Other types of follicular non-Hodgkin's lymphoma
0.000 0.427 0.573
E06 Thyroiditis
0.000 0.427 0.573
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.000 0.429 0.571
C82.3 Follicular lymphoma grade IIIa
0.000 0.431 0.569
C83.9 Diffuse non-Hodgkin's lymphoma, unspecified
0.000 0.438 0.562
E10.3 With ophthalmic complications
0.000 0.438 0.562
C81.9 Hodgkin's disease, unspecified
0.000 0.446 0.554
E10.9 Without complications
0.000 0.451 0.549
L40.3 Pustulosis palmaris et plantaris
0.000 0.455 0.545
C81.1 Nodular sclerosis
0.000 0.462 0.538
E24 Cushing's syndrome
0.000 0.462 0.538
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.000 0.469 0.531
C84 Peripheral and cutaneous T-cell lymphomas
0.000 0.470 0.530
E46 Unspecified protein-energy malnutrition
0.000 0.472 0.528
E11 Non-insulin-dependent diabetes mellitus
0.000 0.483 0.517
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.000 0.486 0.513
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.000 0.486 0.513
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.000 0.486 0.513
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.000 0.486 0.513
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.486 0.513
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.000 0.486 0.513
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.000 0.486 0.513
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.000 0.486 0.513
E28 Ovarian dysfunction
0.000 0.486 0.514
C83.6 Undifferentiated (diffuse)
0.000 0.488 0.511
C83.4 Immunoblastic (diffuse)
0.000 0.488 0.511
C83.2 Mixed small and large cell (diffuse)
0.000 0.488 0.511
E89.4 Postprocedural ovarian failure
0.000 0.492 0.508
E78.6 Lipoprotein deficiency
0.000 0.492 0.508
E78.1 Pure hyperglyceridaemia
0.000 0.492 0.508
E21.3 Hyperparathyroidism, unspecified
0.000 0.494 0.506
E13 Other specified diabetes mellitus
0.000 0.498 0.502
C82.0 Small cleaved cell, follicular
0.000 0.500 0.500
C96 Other and unspecified malignant neoplasms of lymphoid, haematopoietic and related tissue
0.000 0.501 0.499
E10.2 With renal complications
0.000 0.501 0.499
C85.0 Lymphosarcoma
0.000 0.502 0.497
K90.8 Other intestinal malabsorption
0.000 0.503 0.497
E74 Other disorders of carbohydrate metabolism
0.001 0.506 0.494
E23 Hypofunction and other disorders of pituitary gland
0.000 0.508 0.492
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.001 0.509 0.490
C82.6 Cutaneous follicle centre lymphoma
0.000 0.509 0.491
C82.5 Diffuse follicle centre lymphoma
0.000 0.509 0.491
E11.0 With coma
0.000 0.510 0.490
C81.2 Mixed cellularity
0.000 0.510 0.490
E72 Other disorders of amino-acid metabolism
0.001 0.514 0.485
E73 Lactose intolerance
0.001 0.515 0.484
E78.4 Other hyperlipidaemia
0.000 0.517 0.483
C83.1 Small cleaved cell (diffuse)
0.000 0.521 0.479
C81.7 Other Hodgkin's disease
0.000 0.522 0.478
E77 Disorders of glycoprotein metabolism
0.001 0.523 0.476
E76 Disorders of glycosaminoglycan metabolism
0.001 0.523 0.476
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.001 0.523 0.476
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.001 0.523 0.476
E12 Malnutrition-related diabetes mellitus
0.000 0.525 0.475
E78.2 Mixed hyperlipidaemia
0.000 0.526 0.474
C86 Other specified types of T/NK-cell lymphoma
0.000 0.526 0.473
C93 Monocytic leukaemia
0.000 0.527 0.473
E14 Unspecified diabetes mellitus
0.000 0.528 0.472
E11.9 Without complications
0.000 0.529 0.471
C94 Other leukaemias of specified cell type
0.000 0.530 0.470
C81.0 Lymphocytic predominance
0.000 0.530 0.470
E28.3 Primary ovarian failure
0.000 0.532 0.468
E25 Adrenogenital disorders
0.000 0.533 0.467
E89.2 Postprocedural hypoparathyroidism
0.000 0.535 0.465
C82.4 Follicular lymphoma grade IIIb
0.000 0.536 0.464
E24.2 Drug-induced Cushing's syndrome
0.000 0.537 0.463
K90.3 Pancreatic steatorrhoea
0.000 0.538 0.462
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.538 0.462
K90.1 Tropical sprue
0.000 0.538 0.462
C81.4 Lymphocyte-rich classical Hodgkin lymphoma
0.000 0.538 0.461
C81.3 Lymphocytic depletion
0.000 0.538 0.461
C85.2 Mediastinal (thymic) large B-cell lymphoma
0.000 0.541 0.458
C88 Malignant immunoproliferative diseases
0.000 0.542 0.458
E11.1 With ketoacidosis
0.000 0.542 0.458
C82.1 Mixed small cleaved and large cell, follicular
0.000 0.546 0.454
C83.5 Lymphoblastic (diffuse)
0.000 0.548 0.452
E70 Disorders of aromatic amino-acid metabolism
0.001 0.550 0.449
C83.8 Other types of diffuse non-Hodgkin's lymphoma
0.000 0.551 0.449
E24.0 Pituitary-dependent Cushing's disease
0.000 0.553 0.447
E89.3 Postprocedural hypopituitarism
0.000 0.554 0.446
E78.3 Hyperchylomicronaemia
0.000 0.556 0.444
C84.5 Other and unspecified T-cell lymphomas
0.000 0.557 0.443
E89.9 Postprocedural endocrine and metabolic disorder, unspecified
0.000 0.560 0.440
E89.8 Other postprocedural endocrine and metabolic disorders
0.000 0.560 0.440
E89.5 Postprocedural testicular hypofunction
0.000 0.560 0.440
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.562 0.438
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.562 0.438
E45 Retarded development following protein-energy malnutrition
0.000 0.562 0.438
E43 Unspecified severe protein-energy malnutrition
0.000 0.562 0.438
E42 Marasmic kwashiorkor
0.000 0.562 0.438
E41 Nutritional marasmus
0.000 0.562 0.438
E40 Kwashiorkor
0.000 0.562 0.438
C85.7 Other specified types of non-Hodgkin's lymphoma
0.000 0.564 0.436
E10.8 With unspecified complications
0.000 0.567 0.433
E23.7 Disorder of pituitary gland, unspecified
0.000 0.570 0.430
E24.9 Cushing's syndrome, unspecified
0.000 0.571 0.429
E21.5 Disorder of parathyroid gland, unspecified
0.000 0.573 0.427
E10.7 With multiple complications
0.000 0.573 0.427
E88 Other metabolic disorders
0.001 0.582 0.417
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.000 0.582 0.418
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.583 0.417
E32 Diseases of thymus
0.000 0.583 0.417
E30 Disorders of puberty, not elsewhere classified
0.000 0.583 0.417
C84.8 Cutaneous T-cell lymphoma, unspecified
0.000 0.585 0.415
C95 Leukaemia of unspecified cell type
0.000 0.586 0.414
E06.5 Other chronic thyroiditis
0.000 0.589 0.411
E06.4 Drug-induced thyroiditis
0.000 0.589 0.411
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.589 0.411
E06.0 Acute thyroiditis
0.000 0.589 0.411
E23.2 Diabetes insipidus
0.000 0.591 0.409
E31 Polyglandular dysfunction
0.000 0.591 0.409
K90.9 Intestinal malabsorption, unspecified
0.000 0.591 0.409
E79 Disorders of purine and pyrimidine metabolism
0.001 0.596 0.402
E80 Disorders of porphyrin and bilirubin metabolism
0.001 0.598 0.401
E23.6 Other disorders of pituitary gland
0.000 0.600 0.400
E10.0 With coma
0.000 0.606 0.394
E89.1 Postprocedural hypoinsulinaemia
0.000 0.608 0.392
E74.3 Other disorders of intestinal carbohydrate absorption
0.000 0.612 0.387
E24.8 Other Cushing's syndrome
0.000 0.614 0.385
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.000 0.614 0.385
E24.3 Ectopic ACTH syndrome
0.000 0.614 0.385
E24.1 Nelson's syndrome
0.000 0.614 0.385
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.000 0.615 0.385
E13.9 Without complications
0.000 0.615 0.385
L40-L45 Papulosquamous disorders
0.000 0.618 0.382
E06.3 Autoimmune thyroiditis
0.000 0.620 0.380
E14.5 With peripheral circulatory complications
0.000 0.620 0.380
C84.9 Mature T/NK-cell lymphoma, unspecified
0.000 0.620 0.380
C84.7 Anaplastic large cell lymphoma, ALK-negative
0.000 0.620 0.380
C84.6 Anaplastic large cell lymphoma, ALK-positive
0.000 0.620 0.380
C84.3 Lymphoepithelioid lymphoma
0.000 0.620 0.380
C84.2 T-zone lymphoma
0.000 0.620 0.380
C84.1 Sezary's diease
0.000 0.620 0.380
E84 Cystic fibrosis
0.001 0.621 0.378
E21.2 Other hyperparathyroidism
0.000 0.622 0.378
E11.6 With other specified complications
0.000 0.627 0.373
E06.9 Thyroiditis, unspecified
0.000 0.628 0.371
E11.7 With multiple complications
0.000 0.629 0.371
C84.0 Mycosis fungoides
0.000 0.631 0.369
E28.9 Ovarian dysfunction, unspecified
0.000 0.632 0.368
E28.8 Other ovarian dysfunction
0.000 0.632 0.368
E28.1 Androgen excess
0.000 0.632 0.368
E28.0 Oestrogen excess
0.000 0.632 0.368
E75.5 Other lipid storage disorders
0.001 0.633 0.366
E14.8 With unspecified complications
0.000 0.634 0.366
E06.1 Subacute thyroiditis
0.000 0.634 0.365
E11.2 With renal complications
0.000 0.635 0.365
E13.3 With ophthalmic complications
0.000 0.638 0.362
E88.8 Other specified metabolic disorders
0.000 0.640 0.360
E13.8 With unspecified complications
0.000 0.640 0.360
E13.7 With multiple complications
0.000 0.640 0.360
E13.6 With other specified complications
0.000 0.640 0.360
E13.5 With peripheral circulatory complications
0.000 0.640 0.360
E13.4 With neurological complications
0.000 0.640 0.360
E13.2 With renal complications
0.000 0.640 0.360
E13.1 With ketoacidosis
0.000 0.640 0.360
E13.0 With coma
0.000 0.640 0.360
C96.9 Malignant neoplasms of lymphoid, haematopoietic and related tissue, unspecified
0.000 0.642 0.358
C96.8 Histiocytic sarcoma
0.000 0.642 0.358
C96.7 Other specified malignant neoplasms of lymphoid, haematopoietic and related tissue
0.000 0.642 0.358
C96.6 Unifocal Langerhans-cell histiocytosis
0.000 0.642 0.358
C96.5 Multifocal and unisystemic Langerhans-cell histiocytosis
0.000 0.642 0.358
C96.4 Sarcoma of dendritic cells (accessory cells)
0.000 0.642 0.358
C96.3 True histiocytic lymphoma
0.000 0.642 0.358
C96.2 Malignant mast cell tumour
0.000 0.642 0.358
C96.1 Malignant histiocytosis
0.000 0.642 0.358
C96.0 Letterer-Siwe disease
0.000 0.642 0.358
E72.0 Disorders of amino-acid transport
0.001 0.642 0.357
E28.2 Polycystic ovarian syndrome
0.000 0.642 0.358
C60-C63 Malignant neoplasms of male genital organs
0.357 0.643 0.000
E73.9 Lactose intolerance, unspecified
0.000 0.644 0.356
E74.9 Disorder of carbohydrate metabolism, unspecified
0.001 0.645 0.354
E74.8 Other specified disorders of carbohydrate metabolism
0.001 0.645 0.354
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
0.001 0.645 0.354
E74.2 Disorders of galactose metabolism
0.001 0.645 0.354
E74.1 Disorders of fructose metabolism
0.001 0.645 0.354
E14.6 With other specified complications
0.000 0.646 0.354
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.000 0.647 0.353
E23.1 Drug-induced hypopituitarism
0.000 0.647 0.353
E26 Hyperaldosteronism
0.000 0.647 0.352
E75.6 Lipid storage disorder, unspecified
0.001 0.648 0.352
E75.4 Neuronal ceroid lipofuscinosis
0.001 0.648 0.352
E75.3 Sphingolipidosis, unspecified
0.001 0.648 0.352
E75.2 Other sphingolipidosis
0.001 0.648 0.352
E75.1 Other gangliosidosis
0.001 0.648 0.352
E75.0 GM2 gangliosidosis
0.001 0.648 0.352
C88.4 Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue [MALT-lymphoma]
0.000 0.649 0.351
E89.6 Postprocedural adrenocortical(-medullary) hypofunction
0.000 0.651 0.349
E72.9 Disorder of amino-acid metabolism, unspecified
0.001 0.651 0.348
E72.8 Other specified disorders of amino-acid metabolism
0.001 0.651 0.348
E72.5 Disorders of glycine metabolism
0.001 0.651 0.348
E72.4 Disorders of ornithine metabolism
0.001 0.651 0.348
E72.3 Disorders of lysine and hydroxylysine metabolism
0.001 0.651 0.348
E72.2 Disorders of urea cycle metabolism
0.001 0.651 0.348
E72.1 Disorders of sulphur-bearing amino-acid metabolism
0.001 0.651 0.348
E73.8 Other lactose intolerance
0.001 0.652 0.347
E73.1 Secondary lactase deficiency
0.001 0.652 0.347
E73.0 Congenital lactase deficiency
0.001 0.652 0.347
E10.6 With other specified complications
0.000 0.655 0.345
E14.3 With ophthalmic complications
0.000 0.657 0.343
E71.3 Disorders of fatty-acid metabolism
0.001 0.658 0.341
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified
0.001 0.658 0.341
E71.1 Other disorders of branched-chain amino-acid metabolism
0.001 0.658 0.341
E71.0 Maple-syrup-urine disease
0.001 0.658 0.341
E76.9 Disorder of glucosaminoglycan metabolism, unspecified
0.001 0.658 0.341
E76.8 Other disorders of glucosaminoglycan metabolism
0.001 0.658 0.341
E76.3 Mucopolysaccharidosis, unspecified
0.001 0.658 0.341
E76.2 Other mucopolysaccharidoses
0.001 0.658 0.341
E76.1 Mucopolysaccharidosis, type II
0.001 0.658 0.341
E76.0 Mucopolysaccharidosis, type I
0.001 0.658 0.341
E77.9 Disorder of glycoprotein metabolism, unspecified
0.001 0.658 0.341
E77.8 Other disorders of glycoprotein metabolism
0.001 0.658 0.341
E77.1 Defects in glycoprotein degradation
0.001 0.658 0.341
E77.0 Defects in posttranslational modification of lysosomal enzymes
0.001 0.658 0.341
E12.9 Without complications
0.000 0.659 0.340
E12.8 With unspecified complications
0.000 0.659 0.340
E12.7 With multiple complications
0.000 0.659 0.340
E12.6 With other specified complications
0.000 0.659 0.340
E12.5 With peripheral circulatory complications
0.000 0.659 0.340
E12.4 With neurological complications
0.000 0.659 0.340
E12.3 With ophthalmic complications
0.000 0.659 0.340
E12.2 With renal complications
0.000 0.659 0.340
E12.1 With ketoacidosis
0.000 0.659 0.340
E12.0 With coma
0.000 0.659 0.340
C86.6 Primary cutaneous CD30-positive T-cell proliferations
0.000 0.660 0.340
C86.4 Blastic NK-cell lymphoma
0.000 0.660 0.340
C86.3 Subcutaneous panniculitis-like T-cell lymphoma
0.000 0.660 0.340
C86.2 Enteropathy-type (intestinal) T-cell lymphoma
0.000 0.660 0.340
C86.1 Hepatosplenic T-cell lymphoma
0.000 0.660 0.340
C86.0 Extranodal NK/T-cell lymphoma, nasal type
0.000 0.660 0.340
C93.9 Monocytic leukaemia, unspecified
0.000 0.661 0.339
C93.7 Other monocytic leukaemia
0.000 0.661 0.339
C93.3 Juvenile myelomonocytic leukaemia
0.000 0.661 0.339
C93.2 Subacute monocytic leukaemia
0.000 0.661 0.339
C93.0 Acute monocytic leukaemia
0.000 0.661 0.339
E21.4 Other specified disorders of parathyroid gland
0.000 0.661 0.339
E14.7 With multiple complications
0.000 0.661 0.338
E14.0 With coma
0.000 0.661 0.338
E88.2 Lipomatosis, not elsewhere classified
0.000 0.662 0.338
C94.7 Other specified leukaemias
0.000 0.663 0.337
C94.5 Acute myelofibrosis
0.000 0.663 0.337
C94.4 Acute panmyelosis
0.000 0.663 0.337
C94.3 Mast cell leukaemia
0.000 0.663 0.337
C94.2 Acute megakaryoblastic leukaemia
0.000 0.663 0.337
C94.1 Chronic erythraemia
0.000 0.663 0.337
C94.0 Acute erythraemia and erythroleukaemia
0.000 0.663 0.337
E25.9 Adrenogenital disorder, unspecified
0.000 0.665 0.335
E25.8 Other adrenogenital disorders
0.000 0.665 0.335
E74.0 Glycogen storage disease
0.001 0.666 0.333
E10.4 With neurological complications
0.000 0.668 0.332
C88.9 Malignant immunoproliferative disease, unspecified
0.000 0.671 0.328
C88.7 Other malignant immunoproliferative diseases
0.000 0.671 0.328
C88.3 Immunoproliferative small intestinal disease
0.000 0.671 0.328
C88.2 Gamma heavy chain disease
0.000 0.671 0.328
C88.1 Alpha heavy chain disease
0.000 0.671 0.328
E70.9 Disorder of aromatic amino-acid metabolism, unspecified
0.001 0.677 0.322
E70.8 Other disorders of aromatic amino-acid metabolism
0.001 0.677 0.322
E70.2 Disorders of tyrosine metabolism
0.001 0.677 0.322
E70.1 Other hyperphenylalaninaemias
0.001 0.677 0.322
E70.0 Classical phenylketonuria
0.001 0.677 0.322
E14.4 With neurological complications
0.000 0.678 0.322
E20 Hypoparathyroidism
0.000 0.683 0.317
I83.9 Varicose veins of lower extremities without ulcer or inflammation
0.317 0.683 0.000
E15 Nondiabetic hypoglycaemic coma
0.000 0.685 0.314
E44.1 Mild protein-energy malnutrition
0.000 0.686 0.314
E44.0 Moderate protein-energy malnutrition
0.000 0.686 0.314
C86.5 Angioimmunoblastic T-cell lymphoma
0.000 0.686 0.314
C93.1 Chronic monocytic leukaemia
0.000 0.687 0.313
E14.2 Withrenal complications
0.000 0.691 0.308
C94.6 Myelodysplastic and myeloproliferative disease, not elsewhere classified
0.000 0.692 0.308
E10.5 With peripheral circulatory complications
0.000 0.695 0.305
E14.9 Without complications
0.000 0.696 0.304
E14.1 With ketoacidosis
0.000 0.697 0.302
E80.6 Other disorders of bilirubin metabolism
0.000 0.699 0.301
E30.9 Disorder of puberty, unspecified
0.000 0.701 0.299
E30.8 Other disorders of puberty
0.000 0.701 0.299
E30.1 Precocious puberty
0.000 0.701 0.299
E30.0 Delayed puberty
0.000 0.701 0.299
E32.9 Disease of thymus, unspecified
0.000 0.701 0.299
E32.8 Other diseases of thymus
0.000 0.701 0.299
E32.1 Abscess of thymus
0.000 0.701 0.299
E32.0 Persistent hyperplasia of thymus
0.000 0.701 0.299
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.701 0.299
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.701 0.299
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.701 0.299
C60 Malignant neoplasm of penis
0.298 0.702 0.000
C95.7 Other leukaemia of unspecified cell type
0.000 0.703 0.297
C95.2 Subacute leukaemia of unspecified cell type
0.000 0.703 0.297
E70.3 Albinism
0.001 0.703 0.296
C95.9 Leukaemia, unspecified
0.000 0.705 0.295
E31.9 Polyglandular dysfunction, unspecified
0.000 0.707 0.293
E31.8 Other polyglandular dysfunction
0.000 0.707 0.293
E31.1 Polyglandular hyperfunction
0.000 0.707 0.293
E79.9 Disorder of purine and pyrimidine metabolism, unspecified
0.001 0.710 0.289
E79.8 Other disorders of purine and pyrimidine metabolism
0.001 0.710 0.289
E79.1 Lesch-Nyhan syndrome
0.001 0.710 0.289
E80.7 Disorder of bilirubin metabolism, unspecified
0.001 0.712 0.288
E80.5 Crigler-Najjar syndrome
0.001 0.712 0.288
E80.3 Defects of catalase and peroxydase
0.001 0.712 0.288
E80.0 Hereditary erythropoietic porphyria
0.001 0.712 0.288
E88.3 Tumour lysis syndrome
0.001 0.713 0.287
L43 Lichen planus
0.000 0.714 0.285
C95.1 Chronic leukaemia of unspecified cell type
0.000 0.715 0.285
E31.0 Autoimmune polyglandular failure
0.000 0.715 0.285
E83 Disorders of mineral metabolism
0.172 0.718 0.109
E65-E68 Obesity and other hyperalimentation
0.000 0.722 0.278
C84.4 Peripheral T-cell lymphoma
0.000 0.722 0.278
L44 Other papulosquamous disorders
0.000 0.726 0.274
L45 Papulosquamous disorders in diseases classified elsewhere
0.000 0.726 0.274
E84.8 Cystic fibrosis with other manifestations
0.001 0.728 0.271
E84.1 Cystic fibrosis with intestinal manifestations
0.001 0.728 0.271
C83.0 Small cell (diffuse)
0.000 0.729 0.271
L42 Pityriasis rosea
0.000 0.729 0.270
E80.2 Other porphyria
0.001 0.732 0.268
E80.1 Porphyria cutanea tarda
0.001 0.732 0.267
E88.9 Metabolic disorder, unspecified
0.001 0.733 0.266
E22 Hyperfunction of pituitary gland
0.000 0.736 0.264
C63 Malignant neoplasm of other and unspecified male genital organs
0.260 0.740 0.000
E10.1 With ketoacidosis
0.000 0.741 0.259
E11.8 With unspecified complications
0.000 0.746 0.254
E26.9 Hyperaldosteronism, unspecified
0.000 0.747 0.253
E26.8 Other hyperaldosteronism
0.000 0.747 0.253
E26.1 Secondary hyperaldosteronism
0.000 0.747 0.253
C88.0 Waldenstrom's macroglobulinaemia
0.000 0.748 0.251
E80.4 Gilbert's syndrome
0.000 0.752 0.248
E29 Testicular dysfunction
0.001 0.754 0.245
L41 Parapsoriasis
0.000 0.754 0.246
E88.1 Lipodystrophy, not elsewhere classified
0.001 0.757 0.242
C60.9 Penis, unspecified
0.241 0.759 0.000
E34 Other endocrine disorders
0.001 0.761 0.238
E84.9 Cystic fibrosis, unspecified
0.001 0.765 0.234
E78.9 Disorder of lipoprotein metabolism, unspecified
0.000 0.765 0.235
C95.0 Acute leukaemia of unspecified cell type
0.001 0.767 0.232
E16 Other disorders of pancreatic internal secretion
0.000 0.767 0.233
C60.1 Glans penis
0.229 0.771 0.000
E20.1 Pseudohypoparathyroidism
0.000 0.772 0.227
E20.0 Idiopathic hypoparathyroidism
0.000 0.772 0.227
E84.0 Cystic fibrosis with pulmonary manifestations
0.001 0.773 0.226
E50-E64 Other nutritional deficiencies
0.000 0.773 0.226
L43.9 Lichen planus, unspecified
0.000 0.775 0.225
C60.0 Prepuce
0.223 0.777 0.000
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
0.001 0.783 0.215
C60.8 Overlapping lesion of penis
0.214 0.786 0.000
C60.2 Body of penis
0.214 0.786 0.000
E11.5 With peripheral circulatory complications
0.000 0.789 0.211
E21.0 Primary hyperparathyroidism
0.000 0.790 0.210
L43.3 Subacute (active) lichen planus
0.000 0.795 0.205
L43.2 Lichenoid drug reaction
0.000 0.795 0.205
L43.1 Bullous lichen planus
0.000 0.795 0.205
L43.0 Hypertrophic lichen planus
0.000 0.795 0.205
E20.8 Other hypoparathyroidism
0.000 0.797 0.203
E83.9 Disorder of mineral metabolism, unspecified
0.132 0.798 0.070
E83.8 Other disorders of mineral metabolism
0.124 0.798 0.078
E83.2 Disorders of zinc metabolism
0.124 0.798 0.078
E83.0 Disorders of copper metabolism
0.124 0.798 0.078
E67 Other hyperalimentation
0.000 0.800 0.200
E68 Sequelae of hyperalimentation
0.000 0.800 0.200
C90 Multiple myeloma and malignant plasma cell neoplasms
0.006 0.802 0.193
L44.9 Papulosquamous disorder, unspecified
0.000 0.803 0.197
L44.8 Other specified papulosquamous disorders
0.000 0.803 0.197
L44.4 Infantile papular acrodermatitis [Giannotti-Crosti]
0.000 0.803 0.197
L44.3 Lichen ruber moniliformis
0.000 0.803 0.197
L44.2 Lichen striatus
0.000 0.803 0.197
L44.1 Lichen nitidus
0.000 0.803 0.197
L44.0 Pityriasis rubra pilaris
0.000 0.803 0.197
C91 Lymphoid leukaemia
0.001 0.805 0.195
L43.8 Other lichen planus
0.000 0.807 0.193
C63.2 Scrotum
0.190 0.809 0.000
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.000 0.810 0.190
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.810 0.189
E22.8 Other hyperfunction of pituitary gland
0.000 0.810 0.189
E26.0 Primary hyperaldosteronism
0.000 0.812 0.188
C63.9 Male genital organ, unspecified
0.186 0.813 0.000
C63.8 Overlapping lesion of male genital organs
0.186 0.813 0.000
C63.7 Other specified male genital organs
0.186 0.813 0.000
C63.1 Spermatic cord
0.186 0.813 0.000
C63.0 Epididymis
0.186 0.813 0.000
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.817 0.183
E65 Localised adiposity
0.000 0.819 0.181
E27 Other disorders of adrenal gland
0.000 0.821 0.178
E34.8 Other specified endocrine disorders
0.000 0.822 0.178
E29.8 Other testicular dysfunction
0.001 0.823 0.176
E29.0 Testicular hyperfunction
0.001 0.823 0.176
L41.9 Parapsoriasis, unspecified
0.000 0.823 0.176
L41.8 Other parapsoriasis
0.000 0.823 0.176
L41.5 Retiform parapsoriasis
0.000 0.823 0.176
L41.4 Large plaque parapsoriasis
0.000 0.823 0.176
L41.3 Small plaque parapsoriasis
0.000 0.823 0.176
L41.2 Lymphomatoid papulosis
0.000 0.823 0.176
L41.0 Pityriasis lichenoides et varioliformis acuta
0.000 0.823 0.176
C91.9 Lymphoid leukaemia, unspecified
0.000 0.828 0.172
E34.5 Androgen resistance syndrome
0.001 0.829 0.171
E34.4 Constitutional tall stature
0.001 0.829 0.171
E34.3 Short stature, not elsewhere classified
0.001 0.829 0.171
E34.2 Ectopic hormone secretion, not elsewhere classified
0.001 0.829 0.171
E34.1 Other hypersecretion of intestinal hormones
0.001 0.829 0.171
E20.9 Hypoparathyroidism, unspecified
0.000 0.832 0.168
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.833 0.167
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.833 0.167
E16.4 Abnormal secretion of gastrin
0.000 0.833 0.167
E16.3 Increased secretion of glucagon
0.000 0.833 0.167
E83.3 Disorders of phosphorus metabolism
0.129 0.833 0.038
E51 Thiamine deficiency
0.000 0.834 0.166
E56 Other vitamin deficiencies
0.000 0.835 0.165
I83 Varicose veins of lower extremities
0.165 0.835 0.000
E88.0 Disorders of plasma-protein metabolism, not elsewhere classified
0.000 0.837 0.163
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.837 0.162
E63 Other nutritional deficiencies
0.000 0.837 0.162
E50 Vitamin A deficiency
0.000 0.837 0.162
E60 Dietary zinc deficiency
0.000 0.837 0.162
E59 Dietary selenium deficiency
0.000 0.837 0.162
E52 Niacin deficiency [pellagra]
0.000 0.837 0.162
E29.9 Testicular dysfunction, unspecified
0.001 0.838 0.161
E16.1 Other hypoglycaemia
0.000 0.839 0.161
E61 Deficiency of other nutrient elements
0.000 0.840 0.160
C62 Malignant neoplasm of testis
0.153 0.847 0.000
E22.1 Hyperprolactinaemia
0.000 0.849 0.151
I83.0 Varicose veins of lower extremities with ulcer
0.151 0.849 0.000
E58 Dietary calcium deficiency
0.000 0.850 0.149
C90.3 Solitary plasmacytoma
0.004 0.851 0.145
E27.9 Disorder of adrenal gland, unspecified
0.000 0.852 0.148
L41.1 Pityriasis lichenoides chronica
0.000 0.852 0.148
C90.1 Plasma cell leukaemia
0.004 0.853 0.143
E67.8 Other specified hyperalimentation
0.000 0.857 0.143
E67.3 Hypervitaminosis D
0.000 0.857 0.143
E67.2 Megavitamin-B6 syndrome
0.000 0.857 0.143
E67.1 Hypercarotenaemia
0.000 0.857 0.143
E67.0 Hypervitaminosis A
0.000 0.857 0.143
C91.8 Mature B-cell leukaemia Burkitt-type
0.001 0.860 0.140
C91.7 Other lymphoid leukaemia
0.001 0.860 0.140
C91.6 Prolymphocytic leukaemia of T-cell type
0.001 0.860 0.140
C91.3 Prolymphocytic leukaemia
0.001 0.860 0.140
C91.2 Subacute lymphocytic leukaemia
0.001 0.860 0.140
E54 Ascorbic acid deficiency
0.000 0.860 0.139
E11.3 With ophthalmic complications
0.000 0.864 0.136
C91.5 Adult T-cell leukaemia
0.001 0.868 0.132
I83.2 Varicose veins of lower extremities with both ulcer and inflammation
0.132 0.868 0.000
E61.2 Magnesium deficiency
0.000 0.869 0.131

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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