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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs2523880
log Bayes Factor = 70.5459
Chromosome 6   position 31,042,769  (GRCh37) Explore rs2523880 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E03.9 Hypothyroidism, unspecified
1.000 0.000 0.000
K90.0 Coeliac disease
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
R31 Unspecified haematuria
1.000 0.000 0.000
L40.9 Psoriasis, unspecified
0.000 0.000 1.000
E10-E14 Diabetes mellitus
0.000 0.001 0.999
E10.1 With ketoacidosis
0.000 0.002 0.998
E10.9 Without complications
0.000 0.003 0.997
E10.3 With ophthalmic complications
0.000 0.004 0.996
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.004 0.996
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.007 0.993
E16 Other disorders of pancreatic internal secretion
0.000 0.009 0.991
E16.2 Hypoglycaemia, unspecified
0.000 0.010 0.990
E00-E07 Disorders of thyroid gland
0.019 0.017 0.964
L40 Psoriasis
0.000 0.020 0.980
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.033 0.967
E05 Thyrotoxicosis [hyperthyroidism]
0.003 0.033 0.964
L40.5 Arthropathic psoriasis
0.000 0.040 0.960
D86.9 Sarcoidosis, unspecified
0.000 0.062 0.938
D86 Sarcoidosis
0.000 0.065 0.935
E11 Non-insulin-dependent diabetes mellitus
0.000 0.072 0.928
L40.0 Psoriasis vulgaris
0.000 0.080 0.920
E10.2 With renal complications
0.000 0.092 0.908
D80-D89 Certain disorders involving the immune mechanism
0.000 0.092 0.908
E10.8 With unspecified complications
0.000 0.110 0.890
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.000 0.111 0.889
E10.4 With neurological complications
0.000 0.115 0.885
D70-D77 Other diseases of blood and blood-forming organs
0.000 0.128 0.872
E10.5 With peripheral circulatory complications
0.000 0.136 0.864
D70 Agranulocytosis
0.000 0.142 0.858
D86.1 Sarcoidosis of lymph nodes
0.000 0.149 0.851
D50-D53 Nutritional anaemias
0.000 0.151 0.849
E11.3 With ophthalmic complications
0.000 0.154 0.846
E11.5 With peripheral circulatory complications
0.000 0.155 0.845
D51 Vitamin B12 deficiency anaemia
0.000 0.173 0.827
E11.4 With neurological complications
0.000 0.177 0.823
E50-E64 Other nutritional deficiencies
0.000 0.177 0.823
E10.6 With other specified complications
0.000 0.190 0.810
D51.0 Vitamin B12 deficiency anaemia due to intrinsic factor deficiency
0.000 0.208 0.792
D86.0 Sarcoidosis of lung
0.000 0.225 0.775
E55 Vitamin D deficiency
0.000 0.228 0.772
D80 Immunodeficiency with predominantly antibody defects
0.000 0.232 0.768
E03 Other hypothyroidism
0.376 0.240 0.384
E10.0 With coma
0.000 0.240 0.759
L40.4 Guttate psoriasis
0.000 0.245 0.755
E11.6 With other specified complications
0.000 0.246 0.754
D75 Other diseases of blood and blood-forming organs
0.000 0.250 0.750
E11.8 With unspecified complications
0.000 0.253 0.747
D86.8 Sarcoidosis of other and combined sites
0.000 0.254 0.745
E11.1 With ketoacidosis
0.000 0.262 0.738
E55.9 Vitamin D deficiency, unspecified
0.000 0.264 0.736
D55-D59 Haemolytic anaemias
0.000 0.264 0.735
D72 Other disorders of white blood cells
0.000 0.268 0.732
L40.1 Generalised pustular psoriasis
0.000 0.272 0.728
E13 Other specified diabetes mellitus
0.000 0.277 0.723
D53 Other nutritional anaemias
0.000 0.277 0.723
D86.2 Sarcoidosis of lung with sarcoidosis of lymph nodes
0.000 0.277 0.722
D51.9 Vitamin B12 deficiency anaemia, unspecified
0.000 0.280 0.720
E10.7 With multiple complications
0.000 0.283 0.717
E12 Malnutrition-related diabetes mellitus
0.000 0.284 0.716
E15 Nondiabetic hypoglycaemic coma
0.000 0.288 0.712
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.289 0.710
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.289 0.710
E16.4 Abnormal secretion of gastrin
0.000 0.289 0.710
E16.3 Increased secretion of glucagon
0.000 0.289 0.710
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.014 0.295 0.691
E00 Congenital iodine-deficiency syndrome
0.014 0.295 0.691
D86.3 Sarcoidosis of skin
0.000 0.296 0.704
L40.3 Pustulosis palmaris et plantaris
0.000 0.298 0.702
L40.2 Acrodermatitis continua
0.000 0.298 0.702
D83 Common variable immunodeficiency
0.000 0.304 0.696
D59 Acquired haemolytic anaemia
0.000 0.304 0.696
E14 Unspecified diabetes mellitus
0.000 0.305 0.695
E05.5 Thyroid crisis or storm
0.002 0.307 0.691
E05.4 Thyrotoxicosis factitia
0.002 0.307 0.691
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.002 0.307 0.691
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.002 0.307 0.691
E40-E46 Malnutrition
0.000 0.309 0.691
E06 Thyroiditis
0.010 0.311 0.679
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions
0.000 0.320 0.680
E02 Subclinical iodine-deficiency hypothyroidism
0.013 0.322 0.665
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.327 0.673
E16.1 Other hypoglycaemia
0.000 0.327 0.673
E11.7 With multiple complications
0.000 0.334 0.666
D75.9 Disease of blood and blood-forming organs, unspecified
0.000 0.335 0.665
D81 Combined immunodeficiencies
0.000 0.349 0.651
E05.8 Other thyrotoxicosis
0.002 0.351 0.646
D72.8 Other specified disorders of white blood cells
0.000 0.357 0.643
D80.1 Nonfamilial hypogammaglobulinaemia
0.000 0.359 0.641
D53.9 Nutritional anaemia, unspecified
0.000 0.368 0.632
D59.9 Acquired haemolytic anaemia, unspecified
0.000 0.373 0.627
D74 Methaemoglobinaemia
0.000 0.375 0.625
D77 Other disorders of blood and blood-forming organs in diseases classified elsewhere
0.000 0.375 0.625
D71 Functional disorders of polymorphonuclear neutrophils
0.000 0.375 0.625
D82 Immunodeficiency associated with other major defects
0.000 0.378 0.622
D80.2 Selective deficiency of immunoglobulin A [IgA]
0.000 0.382 0.618
E51 Thiamine deficiency
0.000 0.382 0.618
D59.1 Other autoimmune haemolytic anaemias
0.000 0.386 0.614
E53 Deficiency of other B group vitamins
0.000 0.394 0.606
E06.9 Thyroiditis, unspecified
0.004 0.400 0.596
D80.3 Selective deficiency of immunoglobulin G [IgG] subclasses
0.000 0.407 0.593
D51.8 Other vitamin B12 deficiency anaemias
0.000 0.407 0.593
D51.3 Other dietary vitamin B12 deficiency anaemia
0.000 0.407 0.593
D51.2 Transcobalamin II deficiency
0.000 0.407 0.593
D51.1 Vitamin B12 deficiency anaemia due to selective vitamin B12 malabsorption with proteinuria
0.000 0.407 0.593
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.410 0.590
E63 Other nutritional deficiencies
0.000 0.410 0.590
E50 Vitamin A deficiency
0.000 0.410 0.590
E60 Dietary zinc deficiency
0.000 0.410 0.590
E59 Dietary selenium deficiency
0.000 0.410 0.590
E52 Niacin deficiency [pellagra]
0.000 0.410 0.590
D75.0 Familial erythrocytosis
0.000 0.414 0.586
D76 Certain diseases involving lymphoreticular tissue and reticulohistiocytic system
0.000 0.416 0.584
E54 Ascorbic acid deficiency
0.000 0.434 0.566
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.002 0.435 0.563
E14.3 With ophthalmic complications
0.000 0.438 0.562
E13.9 Without complications
0.000 0.442 0.558
D69 Purpura and other haemorrhagic conditions
0.000 0.442 0.558
D84 Other immunodeficiencies
0.000 0.444 0.555
E55.0 Rickets, active
0.000 0.446 0.554
E20-E35 Disorders of other endocrine glands
0.000 0.447 0.553
D80.8 Other immunodeficiencies with predominantly antibody defects
0.000 0.449 0.550
D80.7 Transient hypogammaglobulinaemia of infancy
0.000 0.449 0.550
D80.6 Antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinaemia
0.000 0.449 0.550
D80.5 Immunodeficiency with increased immunoglobulin M [IgM]
0.000 0.449 0.550
D80.0 Hereditary hypogammaglobulinaemia
0.000 0.449 0.550
E14.8 With unspecified complications
0.000 0.450 0.549
E27.1 Primary adrenocortical insufficiency
0.000 0.451 0.549
D66 Hereditary factor VIII deficiency
0.000 0.451 0.549
E27 Other disorders of adrenal gland
0.000 0.454 0.546
E03.5 Myxoedema coma
0.269 0.455 0.276
E03.4 Atrophy of thyroid (acquired)
0.269 0.455 0.276
E03.3 Postinfectious hypothyroidism
0.269 0.455 0.276
D83.9 Common variable immunodeficiency, unspecified
0.000 0.455 0.544
D80.9 Immunodeficiency with predominantly antibody defects, unspecified
0.000 0.457 0.543
E58 Dietary calcium deficiency
0.000 0.458 0.541
D65 Disseminated intravascular coagulation [defibrination syndrome]
0.000 0.459 0.541
E65-E68 Obesity and other hyperalimentation
0.000 0.463 0.537
E56 Other vitamin deficiencies
0.000 0.464 0.536
E05.9 Thyrotoxicosis, unspecified
0.000 0.464 0.536
E14.1 With ketoacidosis
0.000 0.464 0.536
E03.0 Congenital hypothyroidism with diffuse goitre
0.268 0.464 0.268
D75.2 Essential thrombocytosis
0.000 0.466 0.534
E03.1 Congenital hypothyroidism without goitre
0.238 0.467 0.295
D55 Anaemia due to enzyme disorders
0.000 0.472 0.527
D72.9 Disorder of white blood cells, unspecified
0.000 0.475 0.525
D72.0 Genetic anomalies of leukocytes
0.000 0.475 0.525
D75.1 Secondary polycythaemia
0.000 0.479 0.521
D53.8 Other specified nutritional anaemias
0.000 0.482 0.518
D53.2 Scorbutic anaemia
0.000 0.482 0.518
D53.1 Other megaloblastic anaemias, not elsewhere classified
0.000 0.482 0.518
D53.0 Protein deficiency anaemia
0.000 0.482 0.518
E13.8 With unspecified complications
0.000 0.482 0.518
E13.7 With multiple complications
0.000 0.482 0.518
E13.6 With other specified complications
0.000 0.482 0.518
E13.5 With peripheral circulatory complications
0.000 0.482 0.518
E13.4 With neurological complications
0.000 0.482 0.518
E13.2 With renal complications
0.000 0.482 0.518
E13.1 With ketoacidosis
0.000 0.482 0.518
E13.0 With coma
0.000 0.482 0.518
D89 Other disorders involving the immune mechanism, not elsewhere classified
0.000 0.485 0.515
L40.8 Other psoriasis
0.000 0.486 0.514
E12.9 Without complications
0.000 0.486 0.513
E12.8 With unspecified complications
0.000 0.486 0.513
E12.7 With multiple complications
0.000 0.486 0.513
E12.6 With other specified complications
0.000 0.486 0.513
E12.5 With peripheral circulatory complications
0.000 0.486 0.513
E12.4 With neurological complications
0.000 0.486 0.513
E12.3 With ophthalmic complications
0.000 0.486 0.513
E12.2 With renal complications
0.000 0.486 0.513
E12.1 With ketoacidosis
0.000 0.486 0.513
E12.0 With coma
0.000 0.486 0.513
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.268 0.487 0.245
E14.6 With other specified complications
0.000 0.490 0.510
D50 Iron deficiency anaemia
0.000 0.490 0.510
E07 Other disorders of thyroid
0.029 0.492 0.479
E14.5 With peripheral circulatory complications
0.000 0.494 0.506
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.010 0.494 0.496
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.010 0.494 0.496
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.010 0.494 0.496
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.010 0.494 0.496
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.010 0.494 0.496
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.010 0.494 0.496
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.010 0.494 0.496
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.010 0.494 0.496
D57 Sickle-cell disorders
0.000 0.498 0.502
D83.8 Other common variable immunodeficiencies
0.000 0.501 0.499
D83.2 Common variable immunodeficiency with autoantibodies to B- or T-cells
0.000 0.501 0.499
D83.1 Common variable immunodeficiency with predominant immunoregulatory T-cell disorders
0.000 0.501 0.499
D83.0 Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function
0.000 0.501 0.499
D59.8 Other acquired haemolytic anaemias
0.000 0.501 0.499
D59.6 Haemoglobinuria due to haemolysis from other external causes
0.000 0.501 0.499
D59.5 Paroxysmal nocturnal haemoglobinuria [Marchiafava-Micheli]
0.000 0.501 0.499
D59.4 Other nonautoimmune haemolytic anaemias
0.000 0.501 0.499
D59.3 Haemolytic-uraemic syndrome
0.000 0.501 0.499
D59.2 Drug-induced nonautoimmune haemolytic anaemia
0.000 0.501 0.499
D59.0 Drug-induced autoimmune haemolytic anaemia
0.000 0.501 0.499
E14.7 With multiple complications
0.000 0.502 0.498
E14.2 Withrenal complications
0.000 0.502 0.498
E14.0 With coma
0.000 0.502 0.498
D72.1 Eosinophilia
0.000 0.502 0.498
D67 Hereditary factor IX deficiency
0.000 0.503 0.497
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.504 0.496
E45 Retarded development following protein-energy malnutrition
0.000 0.504 0.496
E43 Unspecified severe protein-energy malnutrition
0.000 0.504 0.496
E42 Marasmic kwashiorkor
0.000 0.504 0.496
E41 Nutritional marasmus
0.000 0.504 0.496
E40 Kwashiorkor
0.000 0.504 0.496
E06.4 Drug-induced thyroiditis
0.007 0.506 0.487
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.007 0.506 0.487
E06.0 Acute thyroiditis
0.007 0.506 0.487
D75.8 Other specified diseases of blood and blood-forming organs
0.000 0.506 0.494
E04 Other non-toxic goitre
0.001 0.510 0.489
E03.8 Other specified hypothyroidism
0.245 0.515 0.240
D69.6 Thrombocytopenia, unspecified
0.000 0.520 0.480
E13.3 With ophthalmic complications
0.000 0.522 0.477
E46 Unspecified protein-energy malnutrition
0.000 0.527 0.473
E51.2 Wernicke's encephalopathy
0.000 0.529 0.470
E53.9 Vitamin B deficiency, unspecified
0.000 0.531 0.469
D58 Other hereditary haemolytic anaemias
0.000 0.531 0.468
D81.9 Combined immunodeficiency, unspecified
0.000 0.533 0.467
D81.8 Other combined immunodeficiencies
0.000 0.533 0.467
D81.7 Major histocompatibility complex class II deficiency
0.000 0.533 0.467
D81.6 Major histocompatibility complex class I deficiency
0.000 0.533 0.467
D81.5 Purine nucleoside phosphorylase [PNP] deficiency
0.000 0.533 0.467
D81.4 Nezelof's syndrome
0.000 0.533 0.467
D81.3 Adenosine deaminase [ADA] deficiency
0.000 0.533 0.467
D81.2 Severe combined immunodeficiency [SCID] with low or normal B-cell numbers
0.000 0.533 0.467
D81.1 Severe combined immunodeficiency [SCID] with low T- and B-cell numbers
0.000 0.533 0.467
D81.0 Severe combined immunodeficiency [SCID] with reticular dysgenesis
0.000 0.533 0.467
E34 Other endocrine disorders
0.000 0.534 0.466
D80.4 Selective deficiency of immunoglobulin M [IgM]
0.000 0.534 0.465
D69.2 Other nonthrombocytopenic purpura
0.000 0.536 0.464
E14.4 With neurological complications
0.000 0.544 0.456
D69.5 Secondary thrombocytopenia
0.000 0.545 0.455
E06.3 Autoimmune thyroiditis
0.004 0.551 0.445
D74.9 Methaemoglobinaemia, unspecified
0.000 0.551 0.448
D74.8 Other methaemoglobinaemias
0.000 0.551 0.448
D74.0 Congenital methaemoglobinaemia
0.000 0.551 0.448
D82.9 Immunodeficiency associated with major defect, unspecified
0.000 0.554 0.446
D82.8 Immunodeficiency associated with other specified major defects
0.000 0.554 0.446
D82.4 Hyperimmunoglobulin E [IgE] syndrome
0.000 0.554 0.446
D82.3 Immunodeficiency following hereditary defective response to Epstein-Barr virus
0.000 0.554 0.446
D82.2 Immunodeficiency with short-limbed stature
0.000 0.554 0.446
D82.0 Wiskott-Aldrich syndrome
0.000 0.554 0.446
E51.9 Thiamine deficiency, unspecified
0.000 0.557 0.443
E51.8 Other manifestations of thiamine deficiency
0.000 0.557 0.443
E51.1 Beriberi
0.000 0.557 0.443
E83.1 Disorders of iron metabolism
0.000 0.561 0.439
D84.1 Defects in the complement system
0.000 0.561 0.438
D50.9 Iron deficiency anaemia, unspecified
0.000 0.564 0.436
E53.1 Pyridoxine deficiency
0.000 0.565 0.435
E53.0 Riboflavin deficiency
0.000 0.565 0.435
E06.1 Subacute thyroiditis
0.008 0.574 0.418
E50.9 Vitamin A deficiency, unspecified
0.000 0.577 0.423
E50.8 Other manifestations of vitamin A deficiency
0.000 0.577 0.423
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.577 0.423
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.577 0.423
E50.5 Vitamin A deficiency with night blindness
0.000 0.577 0.423
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.577 0.423
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.577 0.423
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.577 0.423
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.577 0.423
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.577 0.423
E63.9 Nutritional deficiency, unspecified
0.000 0.577 0.423
E63.8 Other specified nutritional deficiencies
0.000 0.577 0.423
E63.1 Imbalance of constituents of food intake
0.000 0.577 0.423
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.577 0.423
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.577 0.423
E64.8 Sequelae of other nutritional deficiencies
0.000 0.577 0.423
E64.3 Sequelae of rickets
0.000 0.577 0.423
E64.2 Sequelae of vitamin C deficiency
0.000 0.577 0.423
E64.1 Sequelae of vitamin A deficiency
0.000 0.577 0.423
E64.0 Sequelae of protein-energy malnutrition
0.000 0.577 0.423
E20 Hypoparathyroidism
0.000 0.578 0.421
D69.3 Idiopathic thrombocytopenic purpura
0.000 0.579 0.421
E70-E90 Metabolic disorders
0.000 0.581 0.419
D76.2 Haemophagocytic syndrome, infection-associated
0.000 0.581 0.419
D76.1 Haemophagocytic lymphohistiocytosis
0.000 0.581 0.419
D76.0 Langerhans' cell histiocytosis, not elsewhere classified
0.000 0.581 0.419
D52 Folate deficiency anaemia
0.000 0.581 0.418
E27.3 Drug-induced adrenocortical insufficiency
0.000 0.583 0.417
D82.1 Di George's syndrome
0.000 0.583 0.417
K90 Intestinal malabsorption
0.000 0.586 0.414
E53.8 Deficiency of other specified B group vitamins
0.000 0.588 0.412
E34.9 Endocrine disorder, unspecified
0.000 0.590 0.410
E25 Adrenogenital disorders
0.000 0.591 0.409
E83 Disorders of mineral metabolism
0.000 0.592 0.408
D69.9 Haemorrhagic condition, unspecified
0.000 0.592 0.408
E06.5 Other chronic thyroiditis
0.008 0.595 0.396
E61 Deficiency of other nutrient elements
0.000 0.600 0.400
D69.8 Other specified haemorrhagic conditions
0.000 0.600 0.400
D84.8 Other specified immunodeficiencies
0.000 0.601 0.398
D84.0 Lymphocyte function antigen-1 [LFA-1] defect
0.000 0.601 0.398
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.604 0.396
E32 Diseases of thymus
0.000 0.604 0.396
E31 Polyglandular dysfunction
0.000 0.604 0.396
E30 Disorders of puberty, not elsewhere classified
0.000 0.604 0.396
E04.0 Non-toxic diffuse goitre
0.001 0.606 0.394
E11.2 With renal complications
0.000 0.606 0.394
E11.0 With coma
0.001 0.608 0.391
D89.8 Other specified disorders involving the immune mechanism, not elsewhere classified
0.000 0.609 0.391
E27.5 Adrenomedullary hyperfunction
0.000 0.609 0.391
E27.0 Other adrenocortical overactivity
0.000 0.609 0.391
E07.8 Other specified disorders of thyroid
0.015 0.609 0.376
E67 Other hyperalimentation
0.000 0.615 0.385
E68 Sequelae of hyperalimentation
0.000 0.615 0.385
E56.9 Vitamin deficiency, unspecified
0.000 0.615 0.384
E56.8 Deficiency of other vitamins
0.000 0.615 0.384
E56.0 Deficiency of vitamin E
0.000 0.615 0.384
E27.2 Addisonian crisis
0.000 0.616 0.384
E04.9 Non-toxic goitre, unspecified
0.000 0.617 0.383
E88 Other metabolic disorders
0.000 0.618 0.382
D55.9 Anaemia due to enzyme disorder, unspecified
0.000 0.622 0.378
D55.8 Other anaemias due to enzyme disorders
0.000 0.622 0.378
D55.3 Anaemia due to disorders of nucleotide metabolism
0.000 0.622 0.378
D55.2 Anaemia due to disorders of glycolytic enzymes
0.000 0.622 0.378
D55.1 Anaemia due to other disorders of glutathione metabolism
0.000 0.622 0.378
D55.0 Anaemia due to glucose-6-phosphate dehydrogenase [G6PD] deficiency
0.000 0.622 0.378
D69.1 Qualitative platelet defects
0.000 0.622 0.377
D76.3 Other histiocytosis syndromes
0.000 0.623 0.377
E27.8 Other specified disorders of adrenal gland
0.000 0.627 0.373
D89.9 Disorder involving the immune mechanism, unspecified
0.000 0.629 0.371
E34.0 Carcinoid syndrome
0.000 0.629 0.371
D89.3 Immune reconstitution syndrome
0.000 0.631 0.369
E85 Amyloidosis
0.000 0.632 0.368
D50.1 Sideropenic dysphagia
0.000 0.634 0.366
E07.1 Dyshormogenetic goitre
0.021 0.636 0.344
E07.0 Hypersecretion of calcitonin
0.021 0.636 0.344
D57.8 Other sickle-cell disorders
0.000 0.640 0.360
D57.3 Sickle-cell trait
0.000 0.640 0.360
D57.2 Double heterozygous sickling disorders
0.000 0.640 0.360
D57.0 Sickle-cell anaemia with crisis
0.000 0.640 0.360
E44.1 Mild protein-energy malnutrition
0.000 0.644 0.355
E44.0 Moderate protein-energy malnutrition
0.000 0.644 0.355
E66 Obesity
0.000 0.645 0.355
D89.1 Cryoglobulinaemia
0.000 0.646 0.354
E04.8 Other specified non-toxic goitre
0.001 0.648 0.351
E88.0 Disorders of plasma-protein metabolism, not elsewhere classified
0.000 0.649 0.351
D58.2 Other haemoglobinopathies
0.000 0.649 0.350
D69.4 Other primary thrombocytopenia
0.000 0.650 0.350
D56 Thalassaemia
0.001 0.661 0.337
D58.8 Other specified hereditary haemolytic anaemias
0.000 0.664 0.336
D58.1 Hereditary elliptocytosis
0.000 0.664 0.336
E34.5 Androgen resistance syndrome
0.000 0.665 0.334
E34.4 Constitutional tall stature
0.000 0.665 0.334
E34.2 Ectopic hormone secretion, not elsewhere classified
0.000 0.665 0.334
E34.1 Other hypersecretion of intestinal hormones
0.000 0.665 0.334
D57.1 Sickle-cell anaemia without crisis
0.000 0.665 0.334
D50.8 Other iron deficiency anaemias
0.000 0.667 0.333
E22 Hyperfunction of pituitary gland
0.000 0.669 0.331
E56.1 Deficiency of vitamin K
0.000 0.669 0.330
E85.4 Organ-limited amyloidosis
0.000 0.671 0.329
E24 Cushing's syndrome
0.000 0.672 0.328
E20.9 Hypoparathyroidism, unspecified
0.000 0.672 0.327
E34.3 Short stature, not elsewhere classified
0.000 0.679 0.320
K90.9 Intestinal malabsorption, unspecified
0.000 0.682 0.318
E79 Disorders of purine and pyrimidine metabolism
0.000 0.685 0.315
E29 Testicular dysfunction
0.000 0.685 0.315
E70 Disorders of aromatic amino-acid metabolism
0.000 0.688 0.312
E27.4 Other and unspecified adrenocortical insufficiency
0.000 0.689 0.311
D89.0 Polyclonal hypergammaglobulinaemia
0.000 0.692 0.308
E88.1 Lipodystrophy, not elsewhere classified
0.000 0.693 0.306
E66.0 Obesity due to excess calories
0.000 0.694 0.306
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.000 0.694 0.305
D58.9 Hereditary haemolytic anaemia, unspecified
0.000 0.695 0.305
E20.8 Other hypoparathyroidism
0.000 0.698 0.302
E20.1 Pseudohypoparathyroidism
0.000 0.698 0.302
E20.0 Idiopathic hypoparathyroidism
0.000 0.698 0.302
E66.2 Extreme obesity with alveolar hypoventilation
0.000 0.698 0.302
D89.2 Hypergammaglobulinaemia, unspecified
0.000 0.699 0.301
E77 Disorders of glycoprotein metabolism
0.000 0.699 0.300
E76 Disorders of glycosaminoglycan metabolism
0.000 0.699 0.300
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.000 0.699 0.300
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.000 0.699 0.300
D52.8 Other folate deficiency anaemias
0.000 0.699 0.300
D52.1 Drug-induced folate deficiency anaemia
0.000 0.699 0.300
D52.0 Dietary folate deficiency anaemia
0.000 0.699 0.300
E88.9 Metabolic disorder, unspecified
0.000 0.702 0.298
K90.3 Pancreatic steatorrhoea
0.000 0.703 0.297
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.703 0.297
K90.1 Tropical sprue
0.000 0.703 0.297
D58.0 Hereditary spherocytosis
0.000 0.705 0.294
E25.9 Adrenogenital disorder, unspecified
0.000 0.707 0.293
E25.8 Other adrenogenital disorders
0.000 0.707 0.293
E83.8 Other disorders of mineral metabolism
0.000 0.707 0.293
E83.2 Disorders of zinc metabolism
0.000 0.707 0.293
E83.0 Disorders of copper metabolism
0.000 0.707 0.293
E84 Cystic fibrosis
0.000 0.708 0.292
K90.8 Other intestinal malabsorption
0.000 0.711 0.289
E61.9 Deficiency of nutrient element, unspecified
0.000 0.713 0.287
E61.8 Deficiency of other specified nutrient elements
0.000 0.713 0.287
E61.7 Deficiency of multiple nutrient elements
0.000 0.713 0.287
E61.6 Vanadium deficiency
0.000 0.713 0.287
E61.5 Molybdenum deficiency
0.000 0.713 0.287
E61.4 Chromium deficiency
0.000 0.713 0.287
E61.3 Manganese deficiency
0.000 0.713 0.287
E61.0 Copper deficiency
0.000 0.713 0.287
E30.9 Disorder of puberty, unspecified
0.000 0.716 0.284
E30.8 Other disorders of puberty
0.000 0.716 0.284
E30.1 Precocious puberty
0.000 0.716 0.284
E30.0 Delayed puberty
0.000 0.716 0.284
E31.9 Polyglandular dysfunction, unspecified
0.000 0.716 0.284
E31.8 Other polyglandular dysfunction
0.000 0.716 0.284
E31.1 Polyglandular hyperfunction
0.000 0.716 0.284
E31.0 Autoimmune polyglandular failure
0.000 0.716 0.284
E32.9 Disease of thymus, unspecified
0.000 0.716 0.284
E32.8 Other diseases of thymus
0.000 0.716 0.284
E32.1 Abscess of thymus
0.000 0.716 0.284
E32.0 Persistent hyperplasia of thymus
0.000 0.716 0.284
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.716 0.284
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.716 0.284
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.716 0.284
E34.8 Other specified endocrine disorders
0.000 0.716 0.284
E83.9 Disorder of mineral metabolism, unspecified
0.000 0.720 0.280
S64.4 Injury of digital nerve of other finger
0.280 0.720 0.000
E85.3 Secondary systemic amyloidosis
0.000 0.722 0.278
E67.8 Other specified hyperalimentation
0.000 0.723 0.276
E67.3 Hypervitaminosis D
0.000 0.723 0.276
E67.2 Megavitamin-B6 syndrome
0.000 0.723 0.276
E67.1 Hypercarotenaemia
0.000 0.723 0.276
E67.0 Hypervitaminosis A
0.000 0.723 0.276
E72 Other disorders of amino-acid metabolism
0.000 0.724 0.276
E27.9 Disorder of adrenal gland, unspecified
0.000 0.728 0.272
E88.3 Tumour lysis syndrome
0.000 0.728 0.272
E26 Hyperaldosteronism
0.000 0.729 0.271
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.000 0.732 0.268
E22.1 Hyperprolactinaemia
0.000 0.734 0.266
E85.8 Other amyloidosis
0.000 0.736 0.264
E85.2 Heredofamilial amyloidosis, unspecified
0.000 0.736 0.264
E85.1 Neuropathic heredofamilial amyloidosis
0.000 0.736 0.264
E85.0 Nonneuropathic heredofamilial amyloidosis
0.000 0.736 0.264
E65 Localised adiposity
0.000 0.737 0.262
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.000 0.739 0.261
E88.8 Other specified metabolic disorders
0.000 0.742 0.258
E85.9 Amyloidosis, unspecified
0.000 0.745 0.255
E66.1 Drug-induced obesity
0.000 0.745 0.255
E74 Other disorders of carbohydrate metabolism
0.000 0.745 0.255
E24.0 Pituitary-dependent Cushing's disease
0.000 0.746 0.254
E61.2 Magnesium deficiency
0.000 0.749 0.251
D56.9 Thalassaemia, unspecified
0.001 0.757 0.242
D56.8 Other thalassaemias
0.001 0.757 0.242
D56.4 Hereditary persistence of foetal haemoglobin [HPFH]
0.001 0.757 0.242
D56.2 Delta-beta thalassaemia
0.001 0.757 0.242
D56.0 Alpha thalassaemia
0.001 0.757 0.242
E04.1 Non-toxic single thyroid nodule
0.000 0.758 0.242
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
0.000 0.759 0.241
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.762 0.238
E22.8 Other hyperfunction of pituitary gland
0.000 0.762 0.238
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.000 0.764 0.235
E24.3 Ectopic ACTH syndrome
0.000 0.764 0.235
E24.1 Nelson's syndrome
0.000 0.764 0.235
E73 Lactose intolerance
0.000 0.765 0.235
E70.3 Albinism
0.000 0.765 0.235
E88.2 Lipomatosis, not elsewhere classified
0.000 0.768 0.232
D60-D64 Aplastic and other anaemias
0.000 0.769 0.231
D73 Diseases of spleen
0.000 0.772 0.228
E24.8 Other Cushing's syndrome
0.000 0.773 0.226
E79.9 Disorder of purine and pyrimidine metabolism, unspecified
0.000 0.774 0.226
E79.8 Other disorders of purine and pyrimidine metabolism
0.000 0.774 0.226
E79.1 Lesch-Nyhan syndrome
0.000 0.774 0.226
E29.9 Testicular dysfunction, unspecified
0.000 0.774 0.226
E29.8 Other testicular dysfunction
0.000 0.774 0.226
E29.0 Testicular hyperfunction
0.000 0.774 0.226
E70.9 Disorder of aromatic amino-acid metabolism, unspecified
0.000 0.776 0.223
E70.8 Other disorders of aromatic amino-acid metabolism
0.000 0.776 0.223
E70.2 Disorders of tyrosine metabolism
0.000 0.776 0.223
E70.1 Other hyperphenylalaninaemias
0.000 0.776 0.223
E70.0 Classical phenylketonuria
0.000 0.776 0.223
D84.9 Immunodeficiency, unspecified
0.001 0.783 0.216
E71.3 Disorders of fatty-acid metabolism
0.000 0.784 0.215
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified
0.000 0.784 0.215
E71.1 Other disorders of branched-chain amino-acid metabolism
0.000 0.784 0.215
E71.0 Maple-syrup-urine disease
0.000 0.784 0.215
E76.9 Disorder of glucosaminoglycan metabolism, unspecified
0.000 0.784 0.215
E76.8 Other disorders of glucosaminoglycan metabolism
0.000 0.784 0.215
E76.3 Mucopolysaccharidosis, unspecified
0.000 0.784 0.215
E76.2 Other mucopolysaccharidoses
0.000 0.784 0.215
E76.1 Mucopolysaccharidosis, type II
0.000 0.784 0.215
E76.0 Mucopolysaccharidosis, type I
0.000 0.784 0.215
E77.9 Disorder of glycoprotein metabolism, unspecified
0.000 0.784 0.215
E77.8 Other disorders of glycoprotein metabolism
0.000 0.784 0.215
E77.1 Defects in glycoprotein degradation
0.000 0.784 0.215
E77.0 Defects in posttranslational modification of lysosomal enzymes
0.000 0.784 0.215
E66.8 Other obesity
0.000 0.789 0.211
E84.8 Cystic fibrosis with other manifestations
0.000 0.791 0.209
E84.1 Cystic fibrosis with intestinal manifestations
0.000 0.791 0.209
E84.0 Cystic fibrosis with pulmonary manifestations
0.000 0.791 0.209
E22.0 Acromegaly and pituitary gigantism
0.000 0.792 0.208
E24.9 Cushing's syndrome, unspecified
0.000 0.794 0.206
E14.9 Without complications
0.000 0.796 0.204
L40-L45 Papulosquamous disorders
0.000 0.798 0.202
E84.9 Cystic fibrosis, unspecified
0.000 0.799 0.200
E72.9 Disorder of amino-acid metabolism, unspecified
0.000 0.802 0.198
E72.8 Other specified disorders of amino-acid metabolism
0.000 0.802 0.198
E72.5 Disorders of glycine metabolism
0.000 0.802 0.198
E72.4 Disorders of ornithine metabolism
0.000 0.802 0.198
E72.3 Disorders of lysine and hydroxylysine metabolism
0.000 0.802 0.198
E72.2 Disorders of urea cycle metabolism
0.000 0.802 0.198
E72.1 Disorders of sulphur-bearing amino-acid metabolism
0.000 0.802 0.198

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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