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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs2523881
log Bayes Factor = 71.155
Chromosome 6   position 31,042,608  (GRCh37) Explore rs2523881 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E03.9 Hypothyroidism, unspecified
1.000 0.000 0.000
K90.0 Coeliac disease
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
R31 Unspecified haematuria
1.000 0.000 0.000
L40.9 Psoriasis, unspecified
0.000 0.000 1.000
E10-E14 Diabetes mellitus
0.000 0.001 0.999
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.002 0.998
E10.1 With ketoacidosis
0.000 0.003 0.997
E16.2 Hypoglycaemia, unspecified
0.000 0.003 0.997
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.003 0.997
E16 Other disorders of pancreatic internal secretion
0.000 0.003 0.997
E10.9 Without complications
0.000 0.004 0.996
E10.3 With ophthalmic complications
0.000 0.006 0.994
L40 Psoriasis
0.000 0.009 0.991
D86.9 Sarcoidosis, unspecified
0.000 0.019 0.981
D86 Sarcoidosis
0.000 0.020 0.980
L40.5 Arthropathic psoriasis
0.000 0.020 0.980
E00-E07 Disorders of thyroid gland
0.061 0.024 0.915
D80-D89 Certain disorders involving the immune mechanism
0.000 0.034 0.966
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.000 0.041 0.959
D70-D77 Other diseases of blood and blood-forming organs
0.000 0.047 0.953
D70 Agranulocytosis
0.000 0.052 0.948
L40.0 Psoriasis vulgaris
0.000 0.053 0.947
E11 Non-insulin-dependent diabetes mellitus
0.000 0.069 0.931
D50-D53 Nutritional anaemias
0.000 0.072 0.928
E05 Thyrotoxicosis [hyperthyroidism]
0.011 0.076 0.914
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.081 0.919
E10.2 With renal complications
0.000 0.084 0.916
D51 Vitamin B12 deficiency anaemia
0.000 0.092 0.908
D86.1 Sarcoidosis of lymph nodes
0.000 0.100 0.900
E10.8 With unspecified complications
0.000 0.110 0.889
D51.0 Vitamin B12 deficiency anaemia due to intrinsic factor deficiency
0.000 0.128 0.872
E11.5 With peripheral circulatory complications
0.000 0.129 0.871
E10.4 With neurological complications
0.000 0.139 0.861
E10.5 With peripheral circulatory complications
0.000 0.150 0.850
D72 Other disorders of white blood cells
0.000 0.160 0.840
D86.0 Sarcoidosis of lung
0.000 0.160 0.840
E11.4 With neurological complications
0.000 0.167 0.833
E11.3 With ophthalmic complications
0.000 0.173 0.827
E10.6 With other specified complications
0.000 0.190 0.810
D51.9 Vitamin B12 deficiency anaemia, unspecified
0.000 0.197 0.803
E50-E64 Other nutritional deficiencies
0.000 0.206 0.794
D53 Other nutritional anaemias
0.000 0.210 0.790
D80 Immunodeficiency with predominantly antibody defects
0.000 0.226 0.774
D86.8 Sarcoidosis of other and combined sites
0.000 0.227 0.773
E03 Other hypothyroidism
0.472 0.228 0.300
E11.8 With unspecified complications
0.000 0.231 0.769
D55-D59 Haemolytic anaemias
0.000 0.233 0.767
L40.4 Guttate psoriasis
0.000 0.236 0.764
L40.1 Generalised pustular psoriasis
0.000 0.237 0.763
D72.8 Other specified disorders of white blood cells
0.000 0.238 0.762
D83 Common variable immunodeficiency
0.000 0.239 0.761
D75 Other diseases of blood and blood-forming organs
0.000 0.239 0.761
E10.0 With coma
0.000 0.241 0.759
D86.3 Sarcoidosis of skin
0.000 0.245 0.755
D86.2 Sarcoidosis of lung with sarcoidosis of lymph nodes
0.000 0.252 0.748
E55 Vitamin D deficiency
0.000 0.257 0.743
E14 Unspecified diabetes mellitus
0.000 0.268 0.732
E11.1 With ketoacidosis
0.000 0.277 0.723
E10.7 With multiple complications
0.000 0.283 0.717
D59 Acquired haemolytic anaemia
0.000 0.283 0.717
E12 Malnutrition-related diabetes mellitus
0.000 0.283 0.716
E15 Nondiabetic hypoglycaemic coma
0.000 0.285 0.715
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.285 0.714
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.285 0.714
E16.4 Abnormal secretion of gastrin
0.000 0.285 0.714
E16.3 Increased secretion of glucagon
0.000 0.285 0.714
L40.3 Pustulosis palmaris et plantaris
0.000 0.289 0.711
L40.2 Acrodermatitis continua
0.000 0.289 0.711
E55.9 Vitamin D deficiency, unspecified
0.000 0.294 0.706
E13 Other specified diabetes mellitus
0.000 0.294 0.706
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.044 0.300 0.656
E00 Congenital iodine-deficiency syndrome
0.044 0.300 0.656
D81 Combined immunodeficiencies
0.000 0.307 0.693
D53.9 Nutritional anaemia, unspecified
0.000 0.310 0.690
E40-E46 Malnutrition
0.000 0.310 0.690
D74 Methaemoglobinaemia
0.000 0.317 0.683
D77 Other disorders of blood and blood-forming organs in diseases classified elsewhere
0.000 0.317 0.683
D71 Functional disorders of polymorphonuclear neutrophils
0.000 0.317 0.683
E11.6 With other specified complications
0.000 0.324 0.676
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.324 0.676
E16.1 Other hypoglycaemia
0.000 0.324 0.676
E02 Subclinical iodine-deficiency hypothyroidism
0.043 0.327 0.630
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions
0.000 0.328 0.672
E06 Thyroiditis
0.032 0.328 0.640
E11.7 With multiple complications
0.000 0.332 0.668
E05.5 Thyroid crisis or storm
0.008 0.337 0.655
E05.4 Thyrotoxicosis factitia
0.008 0.337 0.655
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.008 0.337 0.655
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.008 0.337 0.655
D82 Immunodeficiency associated with other major defects
0.000 0.338 0.662
D75.9 Disease of blood and blood-forming organs, unspecified
0.000 0.344 0.656
D51.8 Other vitamin B12 deficiency anaemias
0.000 0.349 0.651
D51.3 Other dietary vitamin B12 deficiency anaemia
0.000 0.349 0.651
D51.2 Transcobalamin II deficiency
0.000 0.349 0.651
D51.1 Vitamin B12 deficiency anaemia due to selective vitamin B12 malabsorption with proteinuria
0.000 0.349 0.651
D59.9 Acquired haemolytic anaemia, unspecified
0.000 0.354 0.646
E83.1 Disorders of iron metabolism
0.000 0.355 0.645
D80.1 Nonfamilial hypogammaglobulinaemia
0.000 0.361 0.639
D76 Certain diseases involving lymphoreticular tissue and reticulohistiocytic system
0.000 0.369 0.631
D50 Iron deficiency anaemia
0.000 0.376 0.624
E05.8 Other thyrotoxicosis
0.008 0.381 0.612
D59.1 Other autoimmune haemolytic anaemias
0.000 0.386 0.614
D83.9 Common variable immunodeficiency, unspecified
0.000 0.387 0.613
E14.3 With ophthalmic complications
0.000 0.389 0.611
E70-E90 Metabolic disorders
0.000 0.394 0.606
D80.2 Selective deficiency of immunoglobulin A [IgA]
0.000 0.396 0.604
D72.9 Disorder of white blood cells, unspecified
0.000 0.397 0.602
D72.0 Genetic anomalies of leukocytes
0.000 0.397 0.602
E83 Disorders of mineral metabolism
0.000 0.402 0.598
D80.3 Selective deficiency of immunoglobulin G [IgG] subclasses
0.000 0.403 0.597
E14.8 With unspecified complications
0.000 0.403 0.597
E51 Thiamine deficiency
0.000 0.404 0.596
D72.1 Eosinophilia
0.000 0.406 0.594
D84 Other immunodeficiencies
0.000 0.418 0.581
D75.0 Familial erythrocytosis
0.000 0.419 0.581
E20-E35 Disorders of other endocrine glands
0.000 0.425 0.575
E06.9 Thyroiditis, unspecified
0.013 0.431 0.557
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.431 0.569
E63 Other nutritional deficiencies
0.000 0.431 0.569
E50 Vitamin A deficiency
0.000 0.431 0.569
E60 Dietary zinc deficiency
0.000 0.431 0.569
E59 Dietary selenium deficiency
0.000 0.431 0.569
E52 Niacin deficiency [pellagra]
0.000 0.431 0.569
D53.8 Other specified nutritional anaemias
0.000 0.434 0.566
D53.2 Scorbutic anaemia
0.000 0.434 0.566
D53.1 Other megaloblastic anaemias, not elsewhere classified
0.000 0.434 0.566
D53.0 Protein deficiency anaemia
0.000 0.434 0.566
E27.1 Primary adrenocortical insufficiency
0.000 0.434 0.566
E14.1 With ketoacidosis
0.000 0.436 0.564
E27 Other disorders of adrenal gland
0.000 0.436 0.564
E14.6 With other specified complications
0.000 0.443 0.557
D80.8 Other immunodeficiencies with predominantly antibody defects
0.000 0.445 0.555
D80.7 Transient hypogammaglobulinaemia of infancy
0.000 0.445 0.555
D80.6 Antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinaemia
0.000 0.445 0.555
D80.5 Immunodeficiency with increased immunoglobulin M [IgM]
0.000 0.445 0.555
D80.0 Hereditary hypogammaglobulinaemia
0.000 0.445 0.555
E03.5 Myxoedema coma
0.339 0.446 0.215
E03.4 Atrophy of thyroid (acquired)
0.339 0.446 0.215
E03.3 Postinfectious hypothyroidism
0.339 0.446 0.215
D55 Anaemia due to enzyme disorders
0.000 0.450 0.550
E07 Other disorders of thyroid
0.076 0.452 0.472
E03.0 Congenital hypothyroidism with diffuse goitre
0.336 0.454 0.209
E54 Ascorbic acid deficiency
0.000 0.454 0.545
D83.8 Other common variable immunodeficiencies
0.000 0.454 0.545
D83.2 Common variable immunodeficiency with autoantibodies to B- or T-cells
0.000 0.454 0.545
D83.1 Common variable immunodeficiency with predominant immunoregulatory T-cell disorders
0.000 0.454 0.545
D83.0 Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function
0.000 0.454 0.545
E88 Other metabolic disorders
0.000 0.455 0.545
E53 Deficiency of other B group vitamins
0.000 0.456 0.544
D66 Hereditary factor VIII deficiency
0.000 0.459 0.541
D75.2 Essential thrombocytosis
0.000 0.460 0.539
D50.9 Iron deficiency anaemia, unspecified
0.000 0.461 0.539
D65 Disseminated intravascular coagulation [defibrination syndrome]
0.000 0.465 0.535
E55.0 Rickets, active
0.000 0.467 0.532
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.354 0.468 0.178
E13.9 Without complications
0.000 0.469 0.531
E03.1 Congenital hypothyroidism without goitre
0.300 0.470 0.230
E85 Amyloidosis
0.000 0.472 0.528
E14.7 With multiple complications
0.000 0.475 0.525
E14.2 Withrenal complications
0.000 0.475 0.525
E14.0 With coma
0.000 0.475 0.525
D57 Sickle-cell disorders
0.000 0.476 0.523
D89 Other disorders involving the immune mechanism, not elsewhere classified
0.000 0.477 0.523
E58 Dietary calcium deficiency
0.000 0.478 0.522
L40.8 Other psoriasis
0.000 0.480 0.519
E56 Other vitamin deficiencies
0.000 0.483 0.517
D80.9 Immunodeficiency with predominantly antibody defects, unspecified
0.000 0.483 0.516
D59.8 Other acquired haemolytic anaemias
0.000 0.486 0.514
D59.6 Haemoglobinuria due to haemolysis from other external causes
0.000 0.486 0.514
D59.5 Paroxysmal nocturnal haemoglobinuria [Marchiafava-Micheli]
0.000 0.486 0.514
D59.4 Other nonautoimmune haemolytic anaemias
0.000 0.486 0.514
D59.3 Haemolytic-uraemic syndrome
0.000 0.486 0.514
D59.2 Drug-induced nonautoimmune haemolytic anaemia
0.000 0.486 0.514
D59.0 Drug-induced autoimmune haemolytic anaemia
0.000 0.486 0.514
E12.9 Without complications
0.000 0.486 0.514
E12.8 With unspecified complications
0.000 0.486 0.514
E12.7 With multiple complications
0.000 0.486 0.514
E12.6 With other specified complications
0.000 0.486 0.514
E12.5 With peripheral circulatory complications
0.000 0.486 0.514
E12.4 With neurological complications
0.000 0.486 0.514
E12.3 With ophthalmic complications
0.000 0.486 0.514
E12.2 With renal complications
0.000 0.486 0.514
E12.1 With ketoacidosis
0.000 0.486 0.514
E12.0 With coma
0.000 0.486 0.514
E65-E68 Obesity and other hyperalimentation
0.000 0.486 0.514
E05.9 Thyrotoxicosis, unspecified
0.000 0.493 0.507
E13.8 With unspecified complications
0.000 0.494 0.506
E13.7 With multiple complications
0.000 0.494 0.506
E13.6 With other specified complications
0.000 0.494 0.506
E13.5 With peripheral circulatory complications
0.000 0.494 0.506
E13.4 With neurological complications
0.000 0.494 0.506
E13.2 With renal complications
0.000 0.494 0.506
E13.1 With ketoacidosis
0.000 0.494 0.506
E13.0 With coma
0.000 0.494 0.506
E14.5 With peripheral circulatory complications
0.000 0.495 0.505
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.008 0.497 0.496
D69 Purpura and other haemorrhagic conditions
0.000 0.497 0.503
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.032 0.498 0.470
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.032 0.498 0.470
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.032 0.498 0.470
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.032 0.498 0.470
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.032 0.498 0.470
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.032 0.498 0.470
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.032 0.498 0.470
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.032 0.498 0.470
E03.8 Other specified hypothyroidism
0.319 0.501 0.181
D75.1 Secondary polycythaemia
0.000 0.501 0.499
D81.9 Combined immunodeficiency, unspecified
0.000 0.503 0.497
D81.8 Other combined immunodeficiencies
0.000 0.503 0.497
D81.7 Major histocompatibility complex class II deficiency
0.000 0.503 0.497
D81.6 Major histocompatibility complex class I deficiency
0.000 0.503 0.497
D81.5 Purine nucleoside phosphorylase [PNP] deficiency
0.000 0.503 0.497
D81.4 Nezelof's syndrome
0.000 0.503 0.497
D81.3 Adenosine deaminase [ADA] deficiency
0.000 0.503 0.497
D81.2 Severe combined immunodeficiency [SCID] with low or normal B-cell numbers
0.000 0.503 0.497
D81.1 Severe combined immunodeficiency [SCID] with low T- and B-cell numbers
0.000 0.503 0.497
D81.0 Severe combined immunodeficiency [SCID] with reticular dysgenesis
0.000 0.503 0.497
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.505 0.495
E45 Retarded development following protein-energy malnutrition
0.000 0.505 0.495
E43 Unspecified severe protein-energy malnutrition
0.000 0.505 0.495
E42 Marasmic kwashiorkor
0.000 0.505 0.495
E41 Nutritional marasmus
0.000 0.505 0.495
E40 Kwashiorkor
0.000 0.505 0.495
E34 Other endocrine disorders
0.000 0.506 0.494
D75.8 Other specified diseases of blood and blood-forming organs
0.000 0.509 0.490
E88.0 Disorders of plasma-protein metabolism, not elsewhere classified
0.000 0.510 0.490
D67 Hereditary factor IX deficiency
0.000 0.510 0.490
D74.9 Methaemoglobinaemia, unspecified
0.000 0.510 0.490
D74.8 Other methaemoglobinaemias
0.000 0.510 0.490
D74.0 Congenital methaemoglobinaemia
0.000 0.510 0.490
E11.2 With renal complications
0.000 0.511 0.489
E06.4 Drug-induced thyroiditis
0.023 0.518 0.459
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.023 0.518 0.459
E06.0 Acute thyroiditis
0.023 0.518 0.459
D58 Other hereditary haemolytic anaemias
0.000 0.519 0.481
E14.4 With neurological complications
0.000 0.520 0.480
D82.9 Immunodeficiency associated with major defect, unspecified
0.000 0.525 0.474
D82.8 Immunodeficiency associated with other specified major defects
0.000 0.525 0.474
D82.4 Hyperimmunoglobulin E [IgE] syndrome
0.000 0.525 0.474
D82.3 Immunodeficiency following hereditary defective response to Epstein-Barr virus
0.000 0.525 0.474
D82.2 Immunodeficiency with short-limbed stature
0.000 0.525 0.474
D82.0 Wiskott-Aldrich syndrome
0.000 0.525 0.474
E85.4 Organ-limited amyloidosis
0.000 0.529 0.471
E46 Unspecified protein-energy malnutrition
0.000 0.530 0.470
D80.4 Selective deficiency of immunoglobulin M [IgM]
0.000 0.531 0.469
E04 Other non-toxic goitre
0.004 0.533 0.462
E13.3 With ophthalmic complications
0.000 0.535 0.465
D50.8 Other iron deficiency anaemias
0.000 0.536 0.464
E20 Hypoparathyroidism
0.000 0.540 0.459
D52 Folate deficiency anaemia
0.000 0.543 0.457
E79 Disorders of purine and pyrimidine metabolism
0.000 0.545 0.455
D84.1 Defects in the complement system
0.000 0.546 0.454
E51.2 Wernicke's encephalopathy
0.000 0.546 0.454
D76.2 Haemophagocytic syndrome, infection-associated
0.000 0.547 0.452
D76.1 Haemophagocytic lymphohistiocytosis
0.000 0.547 0.452
D76.0 Langerhans' cell histiocytosis, not elsewhere classified
0.000 0.547 0.452
E70 Disorders of aromatic amino-acid metabolism
0.000 0.550 0.450
D50.1 Sideropenic dysphagia
0.000 0.552 0.447
D82.1 Di George's syndrome
0.000 0.557 0.443
E34.9 Endocrine disorder, unspecified
0.000 0.558 0.442
E06.3 Autoimmune thyroiditis
0.012 0.562 0.426
E88.1 Lipodystrophy, not elsewhere classified
0.000 0.563 0.437
E77 Disorders of glycoprotein metabolism
0.000 0.565 0.434
E76 Disorders of glycosaminoglycan metabolism
0.000 0.565 0.434
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.000 0.565 0.434
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.000 0.565 0.434
E27.3 Drug-induced adrenocortical insufficiency
0.000 0.569 0.431
E83.8 Other disorders of mineral metabolism
0.000 0.571 0.429
E83.2 Disorders of zinc metabolism
0.000 0.571 0.429
E83.0 Disorders of copper metabolism
0.000 0.571 0.429
E51.9 Thiamine deficiency, unspecified
0.000 0.573 0.427
E51.8 Other manifestations of thiamine deficiency
0.000 0.573 0.427
E51.1 Beriberi
0.000 0.573 0.427
E88.9 Metabolic disorder, unspecified
0.000 0.574 0.426
E25 Adrenogenital disorders
0.000 0.575 0.425
D69.6 Thrombocytopenia, unspecified
0.000 0.580 0.420
E06.1 Subacute thyroiditis
0.025 0.581 0.393
D69.2 Other nonthrombocytopenic purpura
0.000 0.582 0.418
D84.8 Other specified immunodeficiencies
0.000 0.583 0.417
D84.0 Lymphocyte function antigen-1 [LFA-1] defect
0.000 0.583 0.417
E53.9 Vitamin B deficiency, unspecified
0.000 0.584 0.416
E07.8 Other specified disorders of thyroid
0.038 0.585 0.377
K90 Intestinal malabsorption
0.000 0.587 0.413
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.588 0.412
E32 Diseases of thymus
0.000 0.588 0.412
E31 Polyglandular dysfunction
0.000 0.588 0.412
E30 Disorders of puberty, not elsewhere classified
0.000 0.588 0.412
E83.9 Disorder of mineral metabolism, unspecified
0.000 0.589 0.411
D69.5 Secondary thrombocytopenia
0.000 0.591 0.409
E11.0 With coma
0.001 0.591 0.408
E50.9 Vitamin A deficiency, unspecified
0.000 0.592 0.408
E50.8 Other manifestations of vitamin A deficiency
0.000 0.592 0.408
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.592 0.408
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.592 0.408
E50.5 Vitamin A deficiency with night blindness
0.000 0.592 0.408
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.592 0.408
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.592 0.408
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.592 0.408
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.592 0.408
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.592 0.408
E63.9 Nutritional deficiency, unspecified
0.000 0.592 0.408
E63.8 Other specified nutritional deficiencies
0.000 0.592 0.408
E63.1 Imbalance of constituents of food intake
0.000 0.592 0.408
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.592 0.408
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.592 0.408
E64.8 Sequelae of other nutritional deficiencies
0.000 0.592 0.408
E64.3 Sequelae of rickets
0.000 0.592 0.408
E64.2 Sequelae of vitamin C deficiency
0.000 0.592 0.408
E64.1 Sequelae of vitamin A deficiency
0.000 0.592 0.408
E64.0 Sequelae of protein-energy malnutrition
0.000 0.592 0.408
E84 Cystic fibrosis
0.000 0.594 0.406
E27.5 Adrenomedullary hyperfunction
0.000 0.595 0.404
E27.0 Other adrenocortical overactivity
0.000 0.595 0.404
E34.0 Carcinoid syndrome
0.000 0.596 0.404
E88.3 Tumour lysis syndrome
0.000 0.597 0.403
D76.3 Other histiocytosis syndromes
0.000 0.600 0.400
E61 Deficiency of other nutrient elements
0.000 0.601 0.399
E06.5 Other chronic thyroiditis
0.026 0.601 0.373
E85.3 Secondary systemic amyloidosis
0.000 0.601 0.398
E72 Other disorders of amino-acid metabolism
0.000 0.601 0.398
D89.8 Other specified disorders involving the immune mechanism, not elsewhere classified
0.000 0.603 0.397
E27.2 Addisonian crisis
0.000 0.604 0.396
D55.9 Anaemia due to enzyme disorder, unspecified
0.000 0.605 0.394
D55.8 Other anaemias due to enzyme disorders
0.000 0.605 0.394
D55.3 Anaemia due to disorders of nucleotide metabolism
0.000 0.605 0.394
D55.2 Anaemia due to disorders of glycolytic enzymes
0.000 0.605 0.394
D55.1 Anaemia due to other disorders of glutathione metabolism
0.000 0.605 0.394
D55.0 Anaemia due to glucose-6-phosphate dehydrogenase [G6PD] deficiency
0.000 0.605 0.394
E07.1 Dyshormogenetic goitre
0.054 0.607 0.339
E07.0 Hypersecretion of calcitonin
0.054 0.607 0.339
E53.1 Pyridoxine deficiency
0.000 0.609 0.390
E53.0 Riboflavin deficiency
0.000 0.609 0.390
D89.9 Disorder involving the immune mechanism, unspecified
0.000 0.614 0.386
E04.0 Non-toxic diffuse goitre
0.002 0.616 0.382
E27.8 Other specified disorders of adrenal gland
0.000 0.620 0.379
E85.8 Other amyloidosis
0.000 0.621 0.379
E85.2 Heredofamilial amyloidosis, unspecified
0.000 0.621 0.379
E85.1 Neuropathic heredofamilial amyloidosis
0.000 0.621 0.379
E85.0 Nonneuropathic heredofamilial amyloidosis
0.000 0.621 0.379
E20.9 Hypoparathyroidism, unspecified
0.000 0.623 0.377
D57.8 Other sickle-cell disorders
0.000 0.624 0.375
D57.3 Sickle-cell trait
0.000 0.624 0.375
D57.2 Double heterozygous sickling disorders
0.000 0.624 0.375
D57.0 Sickle-cell anaemia with crisis
0.000 0.624 0.375
D89.3 Immune reconstitution syndrome
0.000 0.625 0.375
E56.9 Vitamin deficiency, unspecified
0.000 0.629 0.371
E56.8 Deficiency of other vitamins
0.000 0.629 0.371
E56.0 Deficiency of vitamin E
0.000 0.629 0.371
E22 Hyperfunction of pituitary gland
0.000 0.631 0.369
E88.8 Other specified metabolic disorders
0.000 0.631 0.369
D56 Thalassaemia
0.001 0.631 0.368
E67 Other hyperalimentation
0.000 0.632 0.368
E68 Sequelae of hyperalimentation
0.000 0.632 0.368
E74 Other disorders of carbohydrate metabolism
0.000 0.632 0.368
D69.9 Haemorrhagic condition, unspecified
0.000 0.633 0.367
E04.9 Non-toxic goitre, unspecified
0.000 0.633 0.366
E85.9 Amyloidosis, unspecified
0.000 0.639 0.360
D69.8 Other specified haemorrhagic conditions
0.000 0.639 0.360
D89.1 Cryoglobulinaemia
0.000 0.640 0.359
D58.2 Other haemoglobinopathies
0.000 0.645 0.355
E44.1 Mild protein-energy malnutrition
0.000 0.645 0.355
E44.0 Moderate protein-energy malnutrition
0.000 0.645 0.355
E34.5 Androgen resistance syndrome
0.000 0.646 0.354
E34.4 Constitutional tall stature
0.000 0.646 0.354
E34.2 Ectopic hormone secretion, not elsewhere classified
0.000 0.646 0.354
E34.1 Other hypersecretion of intestinal hormones
0.000 0.646 0.354
E73 Lactose intolerance
0.000 0.649 0.351
E86 Volume depletion
0.000 0.650 0.350
D57.1 Sickle-cell anaemia without crisis
0.000 0.651 0.348
D69.3 Idiopathic thrombocytopenic purpura
0.000 0.652 0.348
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.000 0.652 0.348
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
0.000 0.652 0.348
D58.8 Other specified hereditary haemolytic anaemias
0.000 0.655 0.345
D58.1 Hereditary elliptocytosis
0.000 0.655 0.345
E29 Testicular dysfunction
0.000 0.659 0.341
D69.1 Qualitative platelet defects
0.000 0.660 0.340
E34.3 Short stature, not elsewhere classified
0.000 0.660 0.339
E70.3 Albinism
0.000 0.661 0.339
E24 Cushing's syndrome
0.000 0.663 0.336
E04.8 Other specified non-toxic goitre
0.003 0.665 0.332
E88.2 Lipomatosis, not elsewhere classified
0.000 0.670 0.330
E53.8 Deficiency of other specified B group vitamins
0.000 0.670 0.330
E20.8 Other hypoparathyroidism
0.000 0.670 0.329
E20.1 Pseudohypoparathyroidism
0.000 0.670 0.329
E20.0 Idiopathic hypoparathyroidism
0.000 0.670 0.329
D52.8 Other folate deficiency anaemias
0.000 0.672 0.328
D52.1 Drug-induced folate deficiency anaemia
0.000 0.672 0.328
D52.0 Dietary folate deficiency anaemia
0.000 0.672 0.328
E79.9 Disorder of purine and pyrimidine metabolism, unspecified
0.000 0.673 0.327
E79.8 Other disorders of purine and pyrimidine metabolism
0.000 0.673 0.327
E79.1 Lesch-Nyhan syndrome
0.000 0.673 0.327
K90.9 Intestinal malabsorption, unspecified
0.000 0.676 0.324
E70.9 Disorder of aromatic amino-acid metabolism, unspecified
0.000 0.677 0.323
E70.8 Other disorders of aromatic amino-acid metabolism
0.000 0.677 0.323
E70.2 Disorders of tyrosine metabolism
0.000 0.677 0.323
E70.1 Other hyperphenylalaninaemias
0.000 0.677 0.323
E70.0 Classical phenylketonuria
0.000 0.677 0.323
E27.4 Other and unspecified adrenocortical insufficiency
0.000 0.681 0.319
E56.1 Deficiency of vitamin K
0.000 0.681 0.318
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.000 0.683 0.317
D69.4 Other primary thrombocytopenia
0.000 0.685 0.315
D58.9 Hereditary haemolytic anaemia, unspecified
0.000 0.687 0.312
E71.3 Disorders of fatty-acid metabolism
0.000 0.688 0.311
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified
0.000 0.688 0.311
E71.1 Other disorders of branched-chain amino-acid metabolism
0.000 0.688 0.311
E71.0 Maple-syrup-urine disease
0.000 0.688 0.311
E76.9 Disorder of glucosaminoglycan metabolism, unspecified
0.000 0.688 0.311
E76.8 Other disorders of glucosaminoglycan metabolism
0.000 0.688 0.311
E76.3 Mucopolysaccharidosis, unspecified
0.000 0.688 0.311
E76.2 Other mucopolysaccharidoses
0.000 0.688 0.311
E76.1 Mucopolysaccharidosis, type II
0.000 0.688 0.311
E76.0 Mucopolysaccharidosis, type I
0.000 0.688 0.311
E77.9 Disorder of glycoprotein metabolism, unspecified
0.000 0.688 0.311
E77.8 Other disorders of glycoprotein metabolism
0.000 0.688 0.311
E77.1 Defects in glycoprotein degradation
0.000 0.688 0.311
E77.0 Defects in posttranslational modification of lysosomal enzymes
0.000 0.688 0.311
D89.0 Polyclonal hypergammaglobulinaemia
0.000 0.693 0.307
E25.9 Adrenogenital disorder, unspecified
0.000 0.695 0.305
E25.8 Other adrenogenital disorders
0.000 0.695 0.305
E66 Obesity
0.000 0.697 0.303
D58.0 Hereditary spherocytosis
0.000 0.698 0.302
K90.3 Pancreatic steatorrhoea
0.000 0.703 0.296
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.703 0.296
K90.1 Tropical sprue
0.000 0.703 0.296
E30.9 Disorder of puberty, unspecified
0.000 0.704 0.295
E30.8 Other disorders of puberty
0.000 0.704 0.295
E30.1 Precocious puberty
0.000 0.704 0.295
E30.0 Delayed puberty
0.000 0.704 0.295
E31.9 Polyglandular dysfunction, unspecified
0.000 0.704 0.295
E31.8 Other polyglandular dysfunction
0.000 0.704 0.295
E31.1 Polyglandular hyperfunction
0.000 0.704 0.295
E31.0 Autoimmune polyglandular failure
0.000 0.704 0.295
E32.9 Disease of thymus, unspecified
0.000 0.704 0.295
E32.8 Other diseases of thymus
0.000 0.704 0.295
E32.1 Abscess of thymus
0.000 0.704 0.295
E32.0 Persistent hyperplasia of thymus
0.000 0.704 0.295
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.704 0.295
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.704 0.295
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.704 0.295
E22.1 Hyperprolactinaemia
0.000 0.707 0.293
E26 Hyperaldosteronism
0.000 0.707 0.292
E84.8 Cystic fibrosis with other manifestations
0.000 0.709 0.291
E84.1 Cystic fibrosis with intestinal manifestations
0.000 0.709 0.291
E84.0 Cystic fibrosis with pulmonary manifestations
0.000 0.709 0.291
E61.9 Deficiency of nutrient element, unspecified
0.000 0.714 0.286
E61.8 Deficiency of other specified nutrient elements
0.000 0.714 0.286
E61.7 Deficiency of multiple nutrient elements
0.000 0.714 0.286
E61.6 Vanadium deficiency
0.000 0.714 0.286
E61.5 Molybdenum deficiency
0.000 0.714 0.286
E61.4 Chromium deficiency
0.000 0.714 0.286
E61.3 Manganese deficiency
0.000 0.714 0.286
E61.0 Copper deficiency
0.000 0.714 0.286
E72.9 Disorder of amino-acid metabolism, unspecified
0.000 0.714 0.286
E72.8 Other specified disorders of amino-acid metabolism
0.000 0.714 0.286
E72.5 Disorders of glycine metabolism
0.000 0.714 0.286
E72.4 Disorders of ornithine metabolism
0.000 0.714 0.286
E72.3 Disorders of lysine and hydroxylysine metabolism
0.000 0.714 0.286
E72.2 Disorders of urea cycle metabolism
0.000 0.714 0.286
E72.1 Disorders of sulphur-bearing amino-acid metabolism
0.000 0.714 0.286
K90.8 Other intestinal malabsorption
0.000 0.716 0.284
E34.8 Other specified endocrine disorders
0.000 0.724 0.276
E65 Localised adiposity
0.000 0.725 0.274
D89.2 Hypergammaglobulinaemia, unspecified
0.000 0.726 0.274
E27.9 Disorder of adrenal gland, unspecified
0.000 0.730 0.270
E80 Disorders of porphyrin and bilirubin metabolism
0.000 0.735 0.265
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.735 0.264
E22.8 Other hyperfunction of pituitary gland
0.000 0.735 0.264
D56.9 Thalassaemia, unspecified
0.001 0.736 0.264
D56.8 Other thalassaemias
0.001 0.736 0.264
D56.4 Hereditary persistence of foetal haemoglobin [HPFH]
0.001 0.736 0.264
D56.2 Delta-beta thalassaemia
0.001 0.736 0.264
D56.0 Alpha thalassaemia
0.001 0.736 0.264
E67.8 Other specified hyperalimentation
0.000 0.736 0.264
E67.3 Hypervitaminosis D
0.000 0.736 0.264
E67.2 Megavitamin-B6 syndrome
0.000 0.736 0.264
E67.1 Hypercarotenaemia
0.000 0.736 0.264
E67.0 Hypervitaminosis A
0.000 0.736 0.264
E74.9 Disorder of carbohydrate metabolism, unspecified
0.000 0.736 0.264
E74.8 Other specified disorders of carbohydrate metabolism
0.000 0.736 0.264
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
0.000 0.736 0.264
E74.2 Disorders of galactose metabolism
0.000 0.736 0.264
E74.1 Disorders of fructose metabolism
0.000 0.736 0.264
E74.0 Glycogen storage disease
0.000 0.736 0.264
E84.9 Cystic fibrosis, unspecified
0.000 0.737 0.262
E22.0 Acromegaly and pituitary gigantism
0.000 0.738 0.262
E24.0 Pituitary-dependent Cushing's disease
0.000 0.740 0.260
E66.2 Extreme obesity with alveolar hypoventilation
0.000 0.743 0.257
E66.0 Obesity due to excess calories
0.000 0.744 0.256
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.000 0.744 0.256
E73.8 Other lactose intolerance
0.000 0.748 0.252
E73.1 Secondary lactase deficiency
0.000 0.748 0.252
E73.0 Congenital lactase deficiency
0.000 0.748 0.252
E61.2 Magnesium deficiency
0.000 0.750 0.250
E75.6 Lipid storage disorder, unspecified
0.000 0.750 0.250
E75.4 Neuronal ceroid lipofuscinosis
0.000 0.750 0.250
E75.3 Sphingolipidosis, unspecified
0.000 0.750 0.250
E75.1 Other gangliosidosis
0.000 0.750 0.250
E75.0 GM2 gangliosidosis
0.000 0.750 0.250
E72.0 Disorders of amino-acid transport
0.000 0.750 0.250

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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