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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs2523888
log Bayes Factor = 72.3468
Chromosome 6   position 31,040,720  (GRCh37) Explore rs2523888 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E03.9 Hypothyroidism, unspecified
1.000 0.000 0.000
K90.0 Coeliac disease
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
R31 Unspecified haematuria
1.000 0.000 0.000
L40.9 Psoriasis, unspecified
0.000 0.000 1.000
E10-E14 Diabetes mellitus
0.000 0.000 1.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.001 0.999
E10.1 With ketoacidosis
0.000 0.002 0.998
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.002 0.998
E16.2 Hypoglycaemia, unspecified
0.000 0.002 0.998
E16 Other disorders of pancreatic internal secretion
0.000 0.003 0.997
E10.9 Without complications
0.000 0.006 0.994
E10.3 With ophthalmic complications
0.000 0.006 0.994
L40 Psoriasis
0.000 0.012 0.988
D86.9 Sarcoidosis, unspecified
0.000 0.016 0.984
D86 Sarcoidosis
0.000 0.016 0.984
E00-E07 Disorders of thyroid gland
0.038 0.016 0.946
D80-D89 Certain disorders involving the immune mechanism
0.000 0.027 0.973
L40.5 Arthropathic psoriasis
0.000 0.029 0.971
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.000 0.034 0.966
D70-D77 Other diseases of blood and blood-forming organs
0.000 0.040 0.960
D70 Agranulocytosis
0.000 0.044 0.956
E05 Thyrotoxicosis [hyperthyroidism]
0.006 0.048 0.945
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.051 0.949
L40.0 Psoriasis vulgaris
0.000 0.058 0.942
E11 Non-insulin-dependent diabetes mellitus
0.000 0.080 0.920
D50-D53 Nutritional anaemias
0.000 0.082 0.918
D86.1 Sarcoidosis of lymph nodes
0.000 0.093 0.907
E10.2 With renal complications
0.000 0.106 0.894
E10.8 With unspecified complications
0.000 0.107 0.893
D51 Vitamin B12 deficiency anaemia
0.000 0.107 0.893
E10.4 With neurological complications
0.000 0.141 0.859
E50-E64 Other nutritional deficiencies
0.000 0.147 0.853
E11.5 With peripheral circulatory complications
0.000 0.152 0.848
D51.0 Vitamin B12 deficiency anaemia due to intrinsic factor deficiency
0.000 0.156 0.844
E10.5 With peripheral circulatory complications
0.000 0.159 0.841
D72 Other disorders of white blood cells
0.000 0.159 0.841
E11.3 With ophthalmic complications
0.000 0.161 0.839
D86.0 Sarcoidosis of lung
0.000 0.173 0.827
E10.6 With other specified complications
0.000 0.186 0.814
E11.4 With neurological complications
0.000 0.186 0.814
E55 Vitamin D deficiency
0.000 0.194 0.806
D51.9 Vitamin B12 deficiency anaemia, unspecified
0.000 0.203 0.797
D80 Immunodeficiency with predominantly antibody defects
0.000 0.205 0.795
D75 Other diseases of blood and blood-forming organs
0.000 0.214 0.786
D53 Other nutritional anaemias
0.000 0.215 0.785
D86.8 Sarcoidosis of other and combined sites
0.000 0.216 0.784
D55-D59 Haemolytic anaemias
0.000 0.216 0.784
E55.9 Vitamin D deficiency, unspecified
0.000 0.228 0.772
D83 Common variable immunodeficiency
0.000 0.231 0.768
D72.8 Other specified disorders of white blood cells
0.000 0.233 0.767
E03 Other hypothyroidism
0.411 0.234 0.355
E10.0 With coma
0.000 0.236 0.764
L40.4 Guttate psoriasis
0.000 0.237 0.762
D86.3 Sarcoidosis of skin
0.000 0.238 0.761
D86.2 Sarcoidosis of lung with sarcoidosis of lymph nodes
0.000 0.246 0.754
E11.8 With unspecified complications
0.000 0.255 0.745
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions
0.000 0.257 0.743
D59 Acquired haemolytic anaemia
0.000 0.263 0.737
L40.1 Generalised pustular psoriasis
0.000 0.264 0.736
E11.1 With ketoacidosis
0.000 0.273 0.727
E14 Unspecified diabetes mellitus
0.000 0.274 0.726
E10.7 With multiple complications
0.000 0.283 0.717
E12 Malnutrition-related diabetes mellitus
0.000 0.283 0.717
E15 Nondiabetic hypoglycaemic coma
0.000 0.284 0.715
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.285 0.715
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.285 0.715
E16.4 Abnormal secretion of gastrin
0.000 0.285 0.715
E16.3 Increased secretion of glucagon
0.000 0.285 0.715
L40.3 Pustulosis palmaris et plantaris
0.000 0.292 0.708
L40.2 Acrodermatitis continua
0.000 0.292 0.708
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.027 0.295 0.678
E00 Congenital iodine-deficiency syndrome
0.027 0.295 0.678
E13 Other specified diabetes mellitus
0.000 0.296 0.704
D81 Combined immunodeficiencies
0.000 0.302 0.698
D53.9 Nutritional anaemia, unspecified
0.000 0.310 0.690
D74 Methaemoglobinaemia
0.000 0.311 0.688
D77 Other disorders of blood and blood-forming organs in diseases classified elsewhere
0.000 0.311 0.688
D71 Functional disorders of polymorphonuclear neutrophils
0.000 0.311 0.688
E40-E46 Malnutrition
0.000 0.312 0.688
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.317 0.683
E05.5 Thyroid crisis or storm
0.005 0.318 0.678
E05.4 Thyrotoxicosis factitia
0.005 0.318 0.678
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.005 0.318 0.678
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.005 0.318 0.678
E16.1 Other hypoglycaemia
0.000 0.318 0.682
E02 Subclinical iodine-deficiency hypothyroidism
0.026 0.319 0.655
E11.6 With other specified complications
0.000 0.320 0.680
D75.9 Disease of blood and blood-forming organs, unspecified
0.000 0.330 0.670
E06 Thyroiditis
0.020 0.332 0.649
D82 Immunodeficiency associated with other major defects
0.000 0.332 0.668
D59.9 Acquired haemolytic anaemia, unspecified
0.000 0.334 0.666
D80.1 Nonfamilial hypogammaglobulinaemia
0.000 0.336 0.664
E11.7 With multiple complications
0.000 0.341 0.659
D76 Certain diseases involving lymphoreticular tissue and reticulohistiocytic system
0.000 0.358 0.642
E05.8 Other thyrotoxicosis
0.004 0.358 0.637
E51 Thiamine deficiency
0.000 0.358 0.641
D51.8 Other vitamin B12 deficiency anaemias
0.000 0.360 0.640
D51.3 Other dietary vitamin B12 deficiency anaemia
0.000 0.360 0.640
D51.2 Transcobalamin II deficiency
0.000 0.360 0.640
D51.1 Vitamin B12 deficiency anaemia due to selective vitamin B12 malabsorption with proteinuria
0.000 0.360 0.640
D59.1 Other autoimmune haemolytic anaemias
0.000 0.361 0.639
E53 Deficiency of other B group vitamins
0.000 0.363 0.637
D80.2 Selective deficiency of immunoglobulin A [IgA]
0.000 0.377 0.623
D83.9 Common variable immunodeficiency, unspecified
0.000 0.378 0.622
D75.0 Familial erythrocytosis
0.000 0.383 0.617
D80.3 Selective deficiency of immunoglobulin G [IgG] subclasses
0.000 0.384 0.616
E14.3 With ophthalmic complications
0.000 0.387 0.613
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.388 0.611
E63 Other nutritional deficiencies
0.000 0.388 0.611
E50 Vitamin A deficiency
0.000 0.388 0.611
E60 Dietary zinc deficiency
0.000 0.388 0.611
E59 Dietary selenium deficiency
0.000 0.388 0.611
E52 Niacin deficiency [pellagra]
0.000 0.388 0.611
D69 Purpura and other haemorrhagic conditions
0.000 0.390 0.610
D66 Hereditary factor VIII deficiency
0.000 0.396 0.604
D72.9 Disorder of white blood cells, unspecified
0.000 0.397 0.603
D72.0 Genetic anomalies of leukocytes
0.000 0.397 0.603
D65 Disseminated intravascular coagulation [defibrination syndrome]
0.000 0.406 0.594
D84 Other immunodeficiencies
0.000 0.410 0.589
E54 Ascorbic acid deficiency
0.000 0.413 0.587
E83.1 Disorders of iron metabolism
0.000 0.422 0.578
E55.0 Rickets, active
0.000 0.422 0.578
E14.8 With unspecified complications
0.000 0.424 0.576
D80.8 Other immunodeficiencies with predominantly antibody defects
0.000 0.430 0.570
D80.7 Transient hypogammaglobulinaemia of infancy
0.000 0.430 0.570
D80.6 Antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinaemia
0.000 0.430 0.570
D80.5 Immunodeficiency with increased immunoglobulin M [IgM]
0.000 0.430 0.570
D80.0 Hereditary hypogammaglobulinaemia
0.000 0.430 0.570
D75.2 Essential thrombocytosis
0.000 0.431 0.569
D89 Other disorders involving the immune mechanism, not elsewhere classified
0.000 0.432 0.568
E05.9 Thyrotoxicosis, unspecified
0.000 0.433 0.567
E06.9 Thyroiditis, unspecified
0.008 0.436 0.556
L40.8 Other psoriasis
0.000 0.437 0.563
D53.8 Other specified nutritional anaemias
0.000 0.437 0.563
D53.2 Scorbutic anaemia
0.000 0.437 0.563
D53.1 Other megaloblastic anaemias, not elsewhere classified
0.000 0.437 0.563
D53.0 Protein deficiency anaemia
0.000 0.437 0.563
D72.1 Eosinophilia
0.000 0.437 0.563
E58 Dietary calcium deficiency
0.000 0.437 0.563
D55 Anaemia due to enzyme disorders
0.000 0.438 0.562
E14.1 With ketoacidosis
0.000 0.438 0.562
E56 Other vitamin deficiencies
0.000 0.443 0.556
E65-E68 Obesity and other hyperalimentation
0.000 0.444 0.556
E70-E90 Metabolic disorders
0.000 0.444 0.556
D83.8 Other common variable immunodeficiencies
0.000 0.449 0.551
D83.2 Common variable immunodeficiency with autoantibodies to B- or T-cells
0.000 0.449 0.551
D83.1 Common variable immunodeficiency with predominant immunoregulatory T-cell disorders
0.000 0.449 0.551
D83.0 Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function
0.000 0.449 0.551
E07 Other disorders of thyroid
0.053 0.450 0.497
E03.5 Myxoedema coma
0.295 0.451 0.255
E03.4 Atrophy of thyroid (acquired)
0.295 0.451 0.255
E03.3 Postinfectious hypothyroidism
0.295 0.451 0.255
E83 Disorders of mineral metabolism
0.000 0.455 0.545
D67 Hereditary factor IX deficiency
0.000 0.457 0.543
E03.0 Congenital hypothyroidism with diffuse goitre
0.292 0.460 0.248
D50 Iron deficiency anaemia
0.000 0.462 0.538
D57 Sickle-cell disorders
0.000 0.464 0.536
E14.6 With other specified complications
0.000 0.465 0.535
E03.1 Congenital hypothyroidism without goitre
0.260 0.468 0.273
D80.9 Immunodeficiency with predominantly antibody defects, unspecified
0.000 0.468 0.532
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.004 0.468 0.527
D59.8 Other acquired haemolytic anaemias
0.000 0.471 0.529
D59.6 Haemoglobinuria due to haemolysis from other external causes
0.000 0.471 0.529
D59.5 Paroxysmal nocturnal haemoglobinuria [Marchiafava-Micheli]
0.000 0.471 0.529
D59.4 Other nonautoimmune haemolytic anaemias
0.000 0.471 0.529
D59.3 Haemolytic-uraemic syndrome
0.000 0.471 0.529
D59.2 Drug-induced nonautoimmune haemolytic anaemia
0.000 0.471 0.529
D59.0 Drug-induced autoimmune haemolytic anaemia
0.000 0.471 0.529
E20-E35 Disorders of other endocrine glands
0.000 0.472 0.528
E13.9 Without complications
0.000 0.473 0.527
D75.8 Other specified diseases of blood and blood-forming organs
0.000 0.474 0.526
D69.6 Thrombocytopenia, unspecified
0.000 0.475 0.525
E27.1 Primary adrenocortical insufficiency
0.000 0.478 0.522
E04 Other non-toxic goitre
0.002 0.479 0.519
E14.7 With multiple complications
0.000 0.479 0.521
E14.2 Withrenal complications
0.000 0.479 0.521
E14.0 With coma
0.000 0.479 0.521
E27 Other disorders of adrenal gland
0.000 0.480 0.520
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.305 0.481 0.213
E12.9 Without complications
0.000 0.486 0.514
E12.8 With unspecified complications
0.000 0.486 0.514
E12.7 With multiple complications
0.000 0.486 0.514
E12.6 With other specified complications
0.000 0.486 0.514
E12.5 With peripheral circulatory complications
0.000 0.486 0.514
E12.4 With neurological complications
0.000 0.486 0.514
E12.3 With ophthalmic complications
0.000 0.486 0.514
E12.2 With renal complications
0.000 0.486 0.514
E12.1 With ketoacidosis
0.000 0.486 0.514
E12.0 With coma
0.000 0.486 0.514
E88 Other metabolic disorders
0.000 0.488 0.512
D69.2 Other nonthrombocytopenic purpura
0.000 0.491 0.509
D75.1 Secondary polycythaemia
0.000 0.492 0.508
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.020 0.494 0.486
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.020 0.494 0.486
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.020 0.494 0.486
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.020 0.494 0.486
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.020 0.494 0.486
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.020 0.494 0.486
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.020 0.494 0.486
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.020 0.494 0.486
E13.8 With unspecified complications
0.000 0.495 0.505
E13.7 With multiple complications
0.000 0.495 0.505
E13.6 With other specified complications
0.000 0.495 0.505
E13.5 With peripheral circulatory complications
0.000 0.495 0.505
E13.4 With neurological complications
0.000 0.495 0.505
E13.2 With renal complications
0.000 0.495 0.505
E13.1 With ketoacidosis
0.000 0.495 0.505
E13.0 With coma
0.000 0.495 0.505
E14.5 With peripheral circulatory complications
0.000 0.497 0.503
D69.5 Secondary thrombocytopenia
0.000 0.498 0.502
D81.9 Combined immunodeficiency, unspecified
0.000 0.500 0.500
D81.8 Other combined immunodeficiencies
0.000 0.500 0.500
D81.7 Major histocompatibility complex class II deficiency
0.000 0.500 0.500
D81.6 Major histocompatibility complex class I deficiency
0.000 0.500 0.500
D81.5 Purine nucleoside phosphorylase [PNP] deficiency
0.000 0.500 0.500
D81.4 Nezelof's syndrome
0.000 0.500 0.500
D81.3 Adenosine deaminase [ADA] deficiency
0.000 0.500 0.500
D81.2 Severe combined immunodeficiency [SCID] with low or normal B-cell numbers
0.000 0.500 0.500
D81.1 Severe combined immunodeficiency [SCID] with low T- and B-cell numbers
0.000 0.500 0.500
D81.0 Severe combined immunodeficiency [SCID] with reticular dysgenesis
0.000 0.500 0.500
D58 Other hereditary haemolytic anaemias
0.000 0.500 0.499
D74.9 Methaemoglobinaemia, unspecified
0.000 0.506 0.494
D74.8 Other methaemoglobinaemias
0.000 0.506 0.494
D74.0 Congenital methaemoglobinaemia
0.000 0.506 0.494
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.506 0.493
E45 Retarded development following protein-energy malnutrition
0.000 0.506 0.493
E43 Unspecified severe protein-energy malnutrition
0.000 0.506 0.493
E42 Marasmic kwashiorkor
0.000 0.506 0.493
E41 Nutritional marasmus
0.000 0.506 0.493
E40 Kwashiorkor
0.000 0.506 0.493
E85 Amyloidosis
0.000 0.510 0.490
E51.2 Wernicke's encephalopathy
0.000 0.510 0.490
E53.9 Vitamin B deficiency, unspecified
0.000 0.510 0.490
E03.8 Other specified hypothyroidism
0.263 0.512 0.226
D80.4 Selective deficiency of immunoglobulin M [IgM]
0.000 0.517 0.483
E14.4 With neurological complications
0.000 0.521 0.479
E06.4 Drug-induced thyroiditis
0.014 0.521 0.465
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.014 0.521 0.465
E06.0 Acute thyroiditis
0.014 0.521 0.465
D82.9 Immunodeficiency associated with major defect, unspecified
0.000 0.521 0.479
D82.8 Immunodeficiency associated with other specified major defects
0.000 0.521 0.479
D82.4 Hyperimmunoglobulin E [IgE] syndrome
0.000 0.521 0.479
D82.3 Immunodeficiency following hereditary defective response to Epstein-Barr virus
0.000 0.521 0.479
D82.2 Immunodeficiency with short-limbed stature
0.000 0.521 0.479
D82.0 Wiskott-Aldrich syndrome
0.000 0.521 0.479
E88.0 Disorders of plasma-protein metabolism, not elsewhere classified
0.000 0.525 0.475
E46 Unspecified protein-energy malnutrition
0.000 0.534 0.466
E13.3 With ophthalmic complications
0.000 0.535 0.465
D84.1 Defects in the complement system
0.000 0.539 0.461
D76.2 Haemophagocytic syndrome, infection-associated
0.000 0.540 0.460
D76.1 Haemophagocytic lymphohistiocytosis
0.000 0.540 0.460
D76.0 Langerhans' cell histiocytosis, not elsewhere classified
0.000 0.540 0.460
E51.9 Thiamine deficiency, unspecified
0.000 0.540 0.460
E51.8 Other manifestations of thiamine deficiency
0.000 0.540 0.460
E51.1 Beriberi
0.000 0.540 0.460
E53.1 Pyridoxine deficiency
0.000 0.543 0.457
E53.0 Riboflavin deficiency
0.000 0.543 0.457
K90 Intestinal malabsorption
0.000 0.545 0.455
D69.3 Idiopathic thrombocytopenic purpura
0.000 0.545 0.455
D52 Folate deficiency anaemia
0.000 0.549 0.450
D69.9 Haemorrhagic condition, unspecified
0.000 0.550 0.450
D82.1 Di George's syndrome
0.000 0.551 0.449
E53.8 Deficiency of other specified B group vitamins
0.000 0.553 0.447
E06.3 Autoimmune thyroiditis
0.008 0.557 0.436
E34 Other endocrine disorders
0.000 0.557 0.443
E85.4 Organ-limited amyloidosis
0.000 0.560 0.440
E50.9 Vitamin A deficiency, unspecified
0.000 0.561 0.438
E50.8 Other manifestations of vitamin A deficiency
0.000 0.561 0.438
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.561 0.438
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.561 0.438
E50.5 Vitamin A deficiency with night blindness
0.000 0.561 0.438
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.561 0.438
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.561 0.438
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.561 0.438
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.561 0.438
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.561 0.438
E63.9 Nutritional deficiency, unspecified
0.000 0.561 0.438
E63.8 Other specified nutritional deficiencies
0.000 0.561 0.438
E63.1 Imbalance of constituents of food intake
0.000 0.561 0.438
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.561 0.438
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.561 0.438
E64.8 Sequelae of other nutritional deficiencies
0.000 0.561 0.438
E64.3 Sequelae of rickets
0.000 0.561 0.438
E64.2 Sequelae of vitamin C deficiency
0.000 0.561 0.438
E64.1 Sequelae of vitamin A deficiency
0.000 0.561 0.438
E64.0 Sequelae of protein-energy malnutrition
0.000 0.561 0.438
D69.8 Other specified haemorrhagic conditions
0.000 0.562 0.438
D50.9 Iron deficiency anaemia, unspecified
0.000 0.564 0.436
E04.0 Non-toxic diffuse goitre
0.001 0.566 0.432
E61 Deficiency of other nutrient elements
0.000 0.567 0.433
D89.8 Other specified disorders involving the immune mechanism, not elsewhere classified
0.000 0.568 0.431
E07.8 Other specified disorders of thyroid
0.026 0.573 0.401
D84.8 Other specified immunodeficiencies
0.000 0.577 0.423
D84.0 Lymphocyte function antigen-1 [LFA-1] defect
0.000 0.577 0.423
D89.9 Disorder involving the immune mechanism, unspecified
0.000 0.578 0.422
E79 Disorders of purine and pyrimidine metabolism
0.000 0.581 0.419
E06.1 Subacute thyroiditis
0.016 0.584 0.400
D69.1 Qualitative platelet defects
0.000 0.586 0.414
E20 Hypoparathyroidism
0.000 0.586 0.414
E70 Disorders of aromatic amino-acid metabolism
0.000 0.586 0.414
D76.3 Other histiocytosis syndromes
0.000 0.586 0.414
E11.0 With coma
0.000 0.586 0.413
E88.1 Lipodystrophy, not elsewhere classified
0.000 0.588 0.412
D89.3 Immune reconstitution syndrome
0.000 0.593 0.407
D55.9 Anaemia due to enzyme disorder, unspecified
0.000 0.597 0.403
D55.8 Other anaemias due to enzyme disorders
0.000 0.597 0.403
D55.3 Anaemia due to disorders of nucleotide metabolism
0.000 0.597 0.403
D55.2 Anaemia due to disorders of glycolytic enzymes
0.000 0.597 0.403
D55.1 Anaemia due to other disorders of glutathione metabolism
0.000 0.597 0.403
D55.0 Anaemia due to glucose-6-phosphate dehydrogenase [G6PD] deficiency
0.000 0.597 0.403
E04.9 Non-toxic goitre, unspecified
0.000 0.597 0.403
E88.9 Metabolic disorder, unspecified
0.000 0.599 0.401
E56.9 Vitamin deficiency, unspecified
0.000 0.601 0.399
E56.8 Deficiency of other vitamins
0.000 0.601 0.399
E56.0 Deficiency of vitamin E
0.000 0.601 0.399
E27.3 Drug-induced adrenocortical insufficiency
0.000 0.601 0.399
E67 Other hyperalimentation
0.000 0.601 0.399
E68 Sequelae of hyperalimentation
0.000 0.601 0.399
E77 Disorders of glycoprotein metabolism
0.000 0.601 0.398
E76 Disorders of glycosaminoglycan metabolism
0.000 0.601 0.398
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.000 0.601 0.398
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.000 0.601 0.398
E06.5 Other chronic thyroiditis
0.016 0.605 0.379
E07.1 Dyshormogenetic goitre
0.038 0.606 0.356
E07.0 Hypersecretion of calcitonin
0.038 0.606 0.356
D89.1 Cryoglobulinaemia
0.000 0.608 0.392
E34.9 Endocrine disorder, unspecified
0.000 0.608 0.392
E83.8 Other disorders of mineral metabolism
0.000 0.609 0.391
E83.2 Disorders of zinc metabolism
0.000 0.609 0.391
E83.0 Disorders of copper metabolism
0.000 0.609 0.391
E25 Adrenogenital disorders
0.000 0.609 0.391
E11.2 With renal complications
0.000 0.610 0.390
D50.8 Other iron deficiency anaemias
0.000 0.611 0.389
D69.4 Other primary thrombocytopenia
0.000 0.614 0.386
D50.1 Sideropenic dysphagia
0.000 0.614 0.386
D57.8 Other sickle-cell disorders
0.000 0.616 0.384
D57.3 Sickle-cell trait
0.000 0.616 0.384
D57.2 Double heterozygous sickling disorders
0.000 0.616 0.384
D57.0 Sickle-cell anaemia with crisis
0.000 0.616 0.384
E66 Obesity
0.000 0.620 0.380
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.621 0.378
E32 Diseases of thymus
0.000 0.621 0.378
E31 Polyglandular dysfunction
0.000 0.621 0.378
E30 Disorders of puberty, not elsewhere classified
0.000 0.621 0.378
E83.9 Disorder of mineral metabolism, unspecified
0.000 0.625 0.375
E04.8 Other specified non-toxic goitre
0.002 0.626 0.372
E84 Cystic fibrosis
0.000 0.627 0.373
E27.5 Adrenomedullary hyperfunction
0.000 0.627 0.373
E27.0 Other adrenocortical overactivity
0.000 0.627 0.373
E85.3 Secondary systemic amyloidosis
0.000 0.628 0.372
D58.2 Other haemoglobinopathies
0.000 0.630 0.370
E27.2 Addisonian crisis
0.000 0.631 0.369
K90.9 Intestinal malabsorption, unspecified
0.000 0.633 0.367
E72 Other disorders of amino-acid metabolism
0.000 0.634 0.366
E88.3 Tumour lysis syndrome
0.000 0.634 0.366
D58.8 Other specified hereditary haemolytic anaemias
0.000 0.642 0.358
D58.1 Hereditary elliptocytosis
0.000 0.642 0.358
D57.1 Sickle-cell anaemia without crisis
0.000 0.642 0.358
D56 Thalassaemia
0.001 0.644 0.355
E34.0 Carcinoid syndrome
0.000 0.646 0.354
E44.1 Mild protein-energy malnutrition
0.000 0.646 0.354
E44.0 Moderate protein-energy malnutrition
0.000 0.646 0.354
E85.8 Other amyloidosis
0.000 0.648 0.352
E85.2 Heredofamilial amyloidosis, unspecified
0.000 0.648 0.352
E85.1 Neuropathic heredofamilial amyloidosis
0.000 0.648 0.352
E85.0 Nonneuropathic heredofamilial amyloidosis
0.000 0.648 0.352
E88.8 Other specified metabolic disorders
0.000 0.652 0.348
E56.1 Deficiency of vitamin K
0.000 0.656 0.344
E27.8 Other specified disorders of adrenal gland
0.000 0.659 0.341
E74 Other disorders of carbohydrate metabolism
0.000 0.660 0.340
E85.9 Amyloidosis, unspecified
0.000 0.661 0.339
D89.0 Polyclonal hypergammaglobulinaemia
0.000 0.665 0.335
E20.9 Hypoparathyroidism, unspecified
0.000 0.667 0.333
D89.2 Hypergammaglobulinaemia, unspecified
0.000 0.670 0.330
D58.9 Hereditary haemolytic anaemia, unspecified
0.000 0.672 0.327
E27.4 Other and unspecified adrenocortical insufficiency
0.000 0.673 0.327
K90.3 Pancreatic steatorrhoea
0.000 0.673 0.326
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.673 0.326
K90.1 Tropical sprue
0.000 0.673 0.326
E66.2 Extreme obesity with alveolar hypoventilation
0.000 0.676 0.324
D52.8 Other folate deficiency anaemias
0.000 0.677 0.323
D52.1 Drug-induced folate deficiency anaemia
0.000 0.677 0.323
D52.0 Dietary folate deficiency anaemia
0.000 0.677 0.323
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
0.000 0.679 0.321
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.000 0.679 0.321
E22 Hyperfunction of pituitary gland
0.000 0.679 0.321
E34.5 Androgen resistance syndrome
0.000 0.682 0.317
E34.4 Constitutional tall stature
0.000 0.682 0.317
E34.2 Ectopic hormone secretion, not elsewhere classified
0.000 0.682 0.317
E34.1 Other hypersecretion of intestinal hormones
0.000 0.682 0.317
E24 Cushing's syndrome
0.000 0.683 0.317
D58.0 Hereditary spherocytosis
0.000 0.683 0.316
E66.0 Obesity due to excess calories
0.000 0.684 0.316
K90.8 Other intestinal malabsorption
0.000 0.685 0.315
E88.2 Lipomatosis, not elsewhere classified
0.000 0.687 0.313
E70.3 Albinism
0.000 0.688 0.312
E73 Lactose intolerance
0.000 0.688 0.312
E61.9 Deficiency of nutrient element, unspecified
0.000 0.689 0.310
E61.8 Deficiency of other specified nutrient elements
0.000 0.689 0.310
E61.7 Deficiency of multiple nutrient elements
0.000 0.689 0.310
E61.6 Vanadium deficiency
0.000 0.689 0.310
E61.5 Molybdenum deficiency
0.000 0.689 0.310
E61.4 Chromium deficiency
0.000 0.689 0.310
E61.3 Manganese deficiency
0.000 0.689 0.310
E61.0 Copper deficiency
0.000 0.689 0.310
E29 Testicular dysfunction
0.000 0.695 0.305
E34.3 Short stature, not elsewhere classified
0.000 0.695 0.305
E79.9 Disorder of purine and pyrimidine metabolism, unspecified
0.000 0.699 0.300
E79.8 Other disorders of purine and pyrimidine metabolism
0.000 0.699 0.300
E79.1 Lesch-Nyhan syndrome
0.000 0.699 0.300
E86 Volume depletion
0.000 0.702 0.298
E20.8 Other hypoparathyroidism
0.000 0.703 0.297
E20.1 Pseudohypoparathyroidism
0.000 0.703 0.297
E20.0 Idiopathic hypoparathyroidism
0.000 0.703 0.297
E70.9 Disorder of aromatic amino-acid metabolism, unspecified
0.000 0.703 0.297
E70.8 Other disorders of aromatic amino-acid metabolism
0.000 0.703 0.297
E70.2 Disorders of tyrosine metabolism
0.000 0.703 0.297
E70.1 Other hyperphenylalaninaemias
0.000 0.703 0.297
E70.0 Classical phenylketonuria
0.000 0.703 0.297
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.000 0.707 0.293
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.000 0.712 0.288
E67.8 Other specified hyperalimentation
0.000 0.714 0.286
E67.3 Hypervitaminosis D
0.000 0.714 0.286
E67.2 Megavitamin-B6 syndrome
0.000 0.714 0.286
E67.1 Hypercarotenaemia
0.000 0.714 0.286
E67.0 Hypervitaminosis A
0.000 0.714 0.286
E71.3 Disorders of fatty-acid metabolism
0.000 0.714 0.286
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified
0.000 0.714 0.286
E71.1 Other disorders of branched-chain amino-acid metabolism
0.000 0.714 0.286
E71.0 Maple-syrup-urine disease
0.000 0.714 0.286
E76.9 Disorder of glucosaminoglycan metabolism, unspecified
0.000 0.714 0.286
E76.8 Other disorders of glucosaminoglycan metabolism
0.000 0.714 0.286
E76.3 Mucopolysaccharidosis, unspecified
0.000 0.714 0.286
E76.2 Other mucopolysaccharidoses
0.000 0.714 0.286
E76.1 Mucopolysaccharidosis, type II
0.000 0.714 0.286
E76.0 Mucopolysaccharidosis, type I
0.000 0.714 0.286
E77.9 Disorder of glycoprotein metabolism, unspecified
0.000 0.714 0.286
E77.8 Other disorders of glycoprotein metabolism
0.000 0.714 0.286
E77.1 Defects in glycoprotein degradation
0.000 0.714 0.286
E77.0 Defects in posttranslational modification of lysosomal enzymes
0.000 0.714 0.286
E25.9 Adrenogenital disorder, unspecified
0.000 0.719 0.280
E25.8 Other adrenogenital disorders
0.000 0.719 0.280
D60-D64 Aplastic and other anaemias
0.000 0.721 0.279
E04.1 Non-toxic single thyroid nodule
0.001 0.724 0.275
E61.2 Magnesium deficiency
0.000 0.727 0.273
E65 Localised adiposity
0.000 0.727 0.273
E66.1 Drug-induced obesity
0.000 0.728 0.272
E30.9 Disorder of puberty, unspecified
0.000 0.728 0.271
E30.8 Other disorders of puberty
0.000 0.728 0.271
E30.1 Precocious puberty
0.000 0.728 0.271
E30.0 Delayed puberty
0.000 0.728 0.271
E31.9 Polyglandular dysfunction, unspecified
0.000 0.728 0.271
E31.8 Other polyglandular dysfunction
0.000 0.728 0.271
E31.1 Polyglandular hyperfunction
0.000 0.728 0.271
E31.0 Autoimmune polyglandular failure
0.000 0.728 0.271
E32.9 Disease of thymus, unspecified
0.000 0.728 0.271
E32.8 Other diseases of thymus
0.000 0.728 0.271
E32.1 Abscess of thymus
0.000 0.728 0.271
E32.0 Persistent hyperplasia of thymus
0.000 0.728 0.271
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.728 0.271
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.728 0.271
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.728 0.271
E84.8 Cystic fibrosis with other manifestations
0.000 0.732 0.268
E84.1 Cystic fibrosis with intestinal manifestations
0.000 0.732 0.268
E84.0 Cystic fibrosis with pulmonary manifestations
0.000 0.732 0.268
E26 Hyperaldosteronism
0.000 0.736 0.264
E72.9 Disorder of amino-acid metabolism, unspecified
0.000 0.737 0.262
E72.8 Other specified disorders of amino-acid metabolism
0.000 0.737 0.262
E72.5 Disorders of glycine metabolism
0.000 0.737 0.262
E72.4 Disorders of ornithine metabolism
0.000 0.737 0.262
E72.3 Disorders of lysine and hydroxylysine metabolism
0.000 0.737 0.262
E72.2 Disorders of urea cycle metabolism
0.000 0.737 0.262
E72.1 Disorders of sulphur-bearing amino-acid metabolism
0.000 0.737 0.262
E66.8 Other obesity
0.000 0.740 0.260
D73 Diseases of spleen
0.000 0.742 0.258
E22.1 Hyperprolactinaemia
0.000 0.743 0.257
D56.9 Thalassaemia, unspecified
0.001 0.745 0.254
D56.8 Other thalassaemias
0.001 0.745 0.254
D56.4 Hereditary persistence of foetal haemoglobin [HPFH]
0.001 0.745 0.254
D56.2 Delta-beta thalassaemia
0.001 0.745 0.254
D56.0 Alpha thalassaemia
0.001 0.745 0.254
E34.8 Other specified endocrine disorders
0.000 0.750 0.249
E24.0 Pituitary-dependent Cushing's disease
0.000 0.754 0.246
S64.4 Injury of digital nerve of other finger
0.244 0.756 0.000
E74.9 Disorder of carbohydrate metabolism, unspecified
0.000 0.756 0.244
E74.8 Other specified disorders of carbohydrate metabolism
0.000 0.756 0.244
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
0.000 0.756 0.244
E74.2 Disorders of galactose metabolism
0.000 0.756 0.244
E74.1 Disorders of fructose metabolism
0.000 0.756 0.244
E74.0 Glycogen storage disease
0.000 0.756 0.244
E84.9 Cystic fibrosis, unspecified
0.000 0.757 0.242
E27.9 Disorder of adrenal gland, unspecified
0.000 0.760 0.239
D84.9 Immunodeficiency, unspecified
0.001 0.767 0.232
E75.6 Lipid storage disorder, unspecified
0.000 0.770 0.230
E75.4 Neuronal ceroid lipofuscinosis
0.000 0.770 0.230
E75.3 Sphingolipidosis, unspecified
0.000 0.770 0.230
E75.1 Other gangliosidosis
0.000 0.770 0.230
E75.0 GM2 gangliosidosis
0.000 0.770 0.230
E72.0 Disorders of amino-acid transport
0.000 0.770 0.230

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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