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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs2524123
log Bayes Factor = 84.3228
Chromosome 6   position 31,265,314  (GRCh37) Explore rs2524123 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
K90.0 Coeliac disease
0.000 0.000 1.000
L40.9 Psoriasis, unspecified
1.000 0.000 0.000
L40.5 Arthropathic psoriasis
1.000 0.000 0.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
L40 Psoriasis
1.000 0.000 0.000
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.000 1.000
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.000 1.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.000 1.000
E00-E07 Disorders of thyroid gland
0.000 0.000 1.000
E10-E14 Diabetes mellitus
0.000 0.000 1.000
L40.0 Psoriasis vulgaris
0.997 0.003 0.000
E10.9 Without complications
0.000 0.005 0.995
E10.3 With ophthalmic complications
0.000 0.005 0.995
E05.9 Thyrotoxicosis, unspecified
0.000 0.010 0.990
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.013 0.987
E16 Other disorders of pancreatic internal secretion
0.000 0.022 0.978
E16.2 Hypoglycaemia, unspecified
0.000 0.028 0.972
J47 Bronchiectasis
0.000 0.035 0.965
E10.2 With renal complications
0.000 0.037 0.963
E10.1 With ketoacidosis
0.000 0.041 0.959
E03.9 Hypothyroidism, unspecified
0.953 0.047 0.000
E10.4 With neurological complications
0.000 0.052 0.948
E50-E64 Other nutritional deficiencies
0.000 0.079 0.921
E05.8 Other thyrotoxicosis
0.000 0.098 0.902
L40.8 Other psoriasis
0.897 0.103 0.000
E06 Thyroiditis
0.000 0.119 0.881
E14 Unspecified diabetes mellitus
0.000 0.119 0.881
L40.1 Generalised pustular psoriasis
0.861 0.139 0.000
E14.3 With ophthalmic complications
0.000 0.170 0.830
E55 Vitamin D deficiency
0.000 0.173 0.827
E03 Other hypothyroidism
0.726 0.175 0.099
E65-E68 Obesity and other hyperalimentation
0.000 0.190 0.810
E10.8 With unspecified complications
0.000 0.204 0.796
E06.9 Thyroiditis, unspecified
0.000 0.215 0.785
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.226 0.774
L40.4 Guttate psoriasis
0.770 0.230 0.000
E10.5 With peripheral circulatory complications
0.000 0.238 0.761
E55.9 Vitamin D deficiency, unspecified
0.000 0.240 0.760
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.243 0.757
E53 Deficiency of other B group vitamins
0.000 0.244 0.756
E10.0 With coma
0.000 0.250 0.750
E14.8 With unspecified complications
0.000 0.273 0.727
E06.3 Autoimmune thyroiditis
0.000 0.281 0.719
E10.7 With multiple complications
0.000 0.283 0.717
L40.3 Pustulosis palmaris et plantaris
0.717 0.283 0.000
L40.2 Acrodermatitis continua
0.717 0.283 0.000
E05.5 Thyroid crisis or storm
0.000 0.283 0.717
E05.4 Thyrotoxicosis factitia
0.000 0.283 0.717
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.283 0.717
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.283 0.717
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.283 0.717
E00 Congenital iodine-deficiency syndrome
0.000 0.283 0.717
E12 Malnutrition-related diabetes mellitus
0.000 0.283 0.717
E15 Nondiabetic hypoglycaemic coma
0.000 0.292 0.708
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.298 0.701
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.298 0.701
E16.4 Abnormal secretion of gastrin
0.000 0.298 0.701
E16.3 Increased secretion of glucagon
0.000 0.298 0.701
E10.6 With other specified complications
0.000 0.307 0.693
E51 Thiamine deficiency
0.000 0.309 0.691
E58 Dietary calcium deficiency
0.000 0.315 0.685
E14.1 With ketoacidosis
0.000 0.330 0.670
M35.3 Polymyalgia rheumatica
0.000 0.330 0.670
E14.6 With other specified complications
0.000 0.334 0.666
E13 Other specified diabetes mellitus
0.000 0.335 0.665
M35 Other systemic involvement of connective tissue
0.000 0.339 0.661
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.339 0.660
E63 Other nutritional deficiencies
0.000 0.339 0.660
E56 Other vitamin deficiencies
0.000 0.339 0.660
E50 Vitamin A deficiency
0.000 0.339 0.660
E60 Dietary zinc deficiency
0.000 0.339 0.660
E59 Dietary selenium deficiency
0.000 0.339 0.660
E54 Ascorbic acid deficiency
0.000 0.339 0.660
E52 Niacin deficiency [pellagra]
0.000 0.339 0.660
M35.0 Sicca syndrome [Sjogren]
0.000 0.353 0.647
E53.9 Vitamin B deficiency, unspecified
0.000 0.358 0.642
E65 Localised adiposity
0.000 0.362 0.638
E03.8 Other specified hypothyroidism
0.591 0.364 0.045
E03.0 Congenital hypothyroidism with diffuse goitre
0.573 0.367 0.061
E06.4 Drug-induced thyroiditis
0.000 0.368 0.632
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.368 0.632
E06.1 Subacute thyroiditis
0.000 0.368 0.632
E06.0 Acute thyroiditis
0.000 0.368 0.632
E14.7 With multiple complications
0.000 0.369 0.631
E14.2 Withrenal complications
0.000 0.369 0.631
E14.0 With coma
0.000 0.369 0.631
E66 Obesity
0.000 0.372 0.628
E14.5 With peripheral circulatory complications
0.000 0.376 0.623
E40-E46 Malnutrition
0.000 0.384 0.616
E61 Deficiency of other nutrient elements
0.000 0.386 0.614
E07 Other disorders of thyroid
0.000 0.389 0.611
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.539 0.401 0.060
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.405 0.595
E04 Other non-toxic goitre
0.000 0.405 0.595
E55.0 Rickets, active
0.000 0.407 0.593
E03.5 Myxoedema coma
0.521 0.409 0.071
E03.4 Atrophy of thyroid (acquired)
0.521 0.409 0.071
E03.3 Postinfectious hypothyroidism
0.521 0.409 0.071
E16.1 Other hypoglycaemia
0.000 0.409 0.591
E67 Other hyperalimentation
0.000 0.419 0.581
E68 Sequelae of hyperalimentation
0.000 0.419 0.581
E03.1 Congenital hypothyroidism without goitre
0.507 0.423 0.070
E66.8 Other obesity
0.000 0.425 0.575
M20-M25 Other joint disorders
0.000 0.427 0.573
M25 Other joint disorders, not elsewhere classified
0.000 0.443 0.557
E06.5 Other chronic thyroiditis
0.000 0.456 0.544
M25.5 Pain in joint
0.000 0.458 0.542
E53.1 Pyridoxine deficiency
0.000 0.458 0.542
E53.0 Riboflavin deficiency
0.000 0.458 0.542
M21 Other acquired deformities of limbs
0.000 0.468 0.532
E53.8 Deficiency of other specified B group vitamins
0.000 0.468 0.532
E51.2 Wernicke's encephalopathy
0.000 0.474 0.526
M25.51 Pain in joint (Shoulder region)
0.000 0.482 0.518
E04.9 Non-toxic goitre, unspecified
0.000 0.484 0.516
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.000 0.486 0.514
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.000 0.486 0.514
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.000 0.486 0.514
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.000 0.486 0.514
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.486 0.514
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.000 0.486 0.514
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.000 0.486 0.514
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.000 0.486 0.514
E12.9 Without complications
0.000 0.486 0.514
E12.8 With unspecified complications
0.000 0.486 0.514
E12.7 With multiple complications
0.000 0.486 0.514
E12.6 With other specified complications
0.000 0.486 0.514
E12.5 With peripheral circulatory complications
0.000 0.486 0.514
E12.4 With neurological complications
0.000 0.486 0.514
E12.3 With ophthalmic complications
0.000 0.486 0.514
E12.2 With renal complications
0.000 0.486 0.514
E12.1 With ketoacidosis
0.000 0.486 0.514
E12.0 With coma
0.000 0.486 0.514
M07.39 Other psoriatic arthropathies (Site unspecified)
0.511 0.489 0.000
M35.7 Hypermobility syndrome
0.000 0.494 0.505
E66.2 Extreme obesity with alveolar hypoventilation
0.000 0.496 0.504
E14.4 With neurological complications
0.000 0.497 0.503
M21.1 Varus deformity, not elsewhere classified
0.000 0.497 0.503
E13.3 With ophthalmic complications
0.000 0.502 0.498
M25.9 Joint disorder, unspecified
0.000 0.503 0.497
E51.9 Thiamine deficiency, unspecified
0.000 0.504 0.495
E51.8 Other manifestations of thiamine deficiency
0.000 0.504 0.495
E51.1 Beriberi
0.000 0.504 0.495
M21.16 Varus deformity, not elsewhere classified (Lower leg)
0.000 0.506 0.494
M25.55 Pain in joint (Pelvic region and thigh)
0.000 0.507 0.493
M34 Systemic sclerosis
0.000 0.509 0.491
M25.6 Stiffness of joint, not elsewhere classified
0.000 0.514 0.486
M07.3 Other psoriatic arthropathies
0.481 0.519 0.000
E61.2 Magnesium deficiency
0.000 0.521 0.479
M21.0 Valgus deformity, not elsewhere classified
0.000 0.522 0.478
E13.8 With unspecified complications
0.000 0.523 0.477
E13.7 With multiple complications
0.000 0.523 0.477
E13.6 With other specified complications
0.000 0.523 0.477
E13.5 With peripheral circulatory complications
0.000 0.523 0.477
E13.4 With neurological complications
0.000 0.523 0.477
E13.2 With renal complications
0.000 0.523 0.477
E13.1 With ketoacidosis
0.000 0.523 0.477
E13.0 With coma
0.000 0.523 0.477
M35.9 Systemic involvement of connective tissue, unspecified
0.000 0.526 0.474
M35.6 Relapsing panniculitis [Weber-Christian]
0.000 0.526 0.474
M35.5 Multifocal fibrosclerosis
0.000 0.526 0.474
M35.4 Diffuse (eosinophilic) fasciitis
0.000 0.526 0.474
E50.9 Vitamin A deficiency, unspecified
0.000 0.526 0.473
E50.8 Other manifestations of vitamin A deficiency
0.000 0.526 0.473
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.526 0.473
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.526 0.473
E50.5 Vitamin A deficiency with night blindness
0.000 0.526 0.473
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.526 0.473
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.526 0.473
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.526 0.473
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.526 0.473
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.526 0.473
E56.9 Vitamin deficiency, unspecified
0.000 0.526 0.473
E56.8 Deficiency of other vitamins
0.000 0.526 0.473
E56.1 Deficiency of vitamin K
0.000 0.526 0.473
E56.0 Deficiency of vitamin E
0.000 0.526 0.473
E63.9 Nutritional deficiency, unspecified
0.000 0.526 0.473
E63.8 Other specified nutritional deficiencies
0.000 0.526 0.473
E63.1 Imbalance of constituents of food intake
0.000 0.526 0.473
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.526 0.473
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.526 0.473
E64.8 Sequelae of other nutritional deficiencies
0.000 0.526 0.473
E64.3 Sequelae of rickets
0.000 0.526 0.473
E64.2 Sequelae of vitamin C deficiency
0.000 0.526 0.473
E64.1 Sequelae of vitamin A deficiency
0.000 0.526 0.473
E64.0 Sequelae of protein-energy malnutrition
0.000 0.526 0.473
M35.1 Other overlap syndromes
0.000 0.526 0.474
M35.2 Behcet's disease
0.000 0.527 0.473
M25.0 Haemarthrosis
0.000 0.532 0.468
M25.59 Pain in joint (Site unspecified)
0.000 0.533 0.467
M25.8 Other specified joint disorders
0.000 0.537 0.463
M25.54 Pain in joint (Hand)
0.000 0.537 0.463
M25.52 Pain in joint (Upper arm)
0.000 0.541 0.459
M25.61 Stiffness of joint, not elsewhere classified (Shoulder region)
0.000 0.541 0.459
M30 Polyarteritis nodosa and related conditions
0.000 0.542 0.458
E20-E35 Disorders of other endocrine glands
0.000 0.543 0.457
M31 Other necrotising vasculopathies
0.000 0.544 0.456
M21.06 Valgus deformity, not elsewhere classified (Lower leg)
0.000 0.546 0.454
E66.0 Obesity due to excess calories
0.000 0.546 0.454
E66.1 Drug-induced obesity
0.000 0.549 0.450
M25.96 Joint disorder, unspecified (Lower leg)
0.000 0.554 0.446
M32 Systemic lupus erythematosus
0.000 0.556 0.444
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.558 0.442
E45 Retarded development following protein-energy malnutrition
0.000 0.558 0.442
E43 Unspecified severe protein-energy malnutrition
0.000 0.558 0.442
E42 Marasmic kwashiorkor
0.000 0.558 0.442
E41 Nutritional marasmus
0.000 0.558 0.442
E40 Kwashiorkor
0.000 0.558 0.442
E07.8 Other specified disorders of thyroid
0.000 0.558 0.442
E61.9 Deficiency of nutrient element, unspecified
0.000 0.560 0.440
E61.8 Deficiency of other specified nutrient elements
0.000 0.560 0.440
E61.7 Deficiency of multiple nutrient elements
0.000 0.560 0.440
E61.6 Vanadium deficiency
0.000 0.560 0.440
E61.5 Molybdenum deficiency
0.000 0.560 0.440
E61.4 Chromium deficiency
0.000 0.560 0.440
E61.3 Manganese deficiency
0.000 0.560 0.440
E61.0 Copper deficiency
0.000 0.560 0.440
M25.58 Pain in joint (Other)
0.000 0.561 0.439
E07.1 Dyshormogenetic goitre
0.000 0.562 0.438
E07.0 Hypersecretion of calcitonin
0.000 0.562 0.438
M21.7 Unequal limb length (acquired)
0.000 0.565 0.435
M07.30 Other psoriatic arthropathies (Multiple sites)
0.433 0.567 0.000
M35.8 Other specified systemic involvement of connective tissue
0.000 0.569 0.431
K90 Intestinal malabsorption
0.000 0.572 0.428
M25.66 Stiffness of joint, not elsewhere classified (Lower leg)
0.000 0.572 0.428
E04.8 Other specified non-toxic goitre
0.000 0.573 0.426
M25.84 Other specified joint disorders (Hand)
0.000 0.575 0.425
E67.8 Other specified hyperalimentation
0.000 0.583 0.416
E67.3 Hypervitaminosis D
0.000 0.583 0.416
E67.2 Megavitamin-B6 syndrome
0.000 0.583 0.416
E67.1 Hypercarotenaemia
0.000 0.583 0.416
E67.0 Hypervitaminosis A
0.000 0.583 0.416
M21.4 Flat foot [pes planus] (acquired)
0.000 0.584 0.416
M22 Disorders of patella
0.000 0.584 0.416
E34 Other endocrine disorders
0.000 0.587 0.413
M34.8 Other forms of systemic sclerosis
0.000 0.590 0.410
M24 Other specific joint derangements
0.000 0.591 0.409
E27 Other disorders of adrenal gland
0.000 0.593 0.407
E27.1 Primary adrenocortical insufficiency
0.000 0.595 0.405
M25.06 Haemarthrosis (Lower leg)
0.000 0.595 0.405
M36 Systemic disorders of connective tissue in diseases classified elsewhere
0.000 0.597 0.403
M07.38 Other psoriatic arthropathies (Other)
0.402 0.598 0.000
M31.6 Other giant cell arteritis
0.000 0.600 0.400
M25.2 Flail joint
0.000 0.600 0.399
M25.1 Fistula of joint
0.000 0.600 0.399
M07.35 Other psoriatic arthropathies (Pelvic region and thigh)
0.399 0.601 0.000
M25.94 Joint disorder, unspecified (Hand)
0.000 0.602 0.398
E22 Hyperfunction of pituitary gland
0.000 0.602 0.398
E13.9 Without complications
0.000 0.606 0.394
M22.4 Chondromalacia patellae
0.000 0.606 0.394
M31.5 Giant cell arteritis with polymyalgia rheumatica
0.000 0.608 0.392
E04.0 Non-toxic diffuse goitre
0.000 0.609 0.390
M21.9 Acquired deformity of limb, unspecified
0.000 0.616 0.384
M25.87 Other specified joint disorders (Ankle and foot)
0.000 0.617 0.383
M07.37 Other psoriatic arthropathies (Ankle and foot)
0.383 0.617 0.000
M32.1 Systemic lupus erythematosus with organ or system involvement
0.000 0.619 0.381
M21.8 Other specified acquired deformities of limbs
0.000 0.620 0.380
M07.34 Other psoriatic arthropathies (Hand)
0.378 0.622 0.000
M24.1 Other articular cartilage disorders
0.000 0.623 0.377
M21.75 Unequal limb length (acquired) (Pelvic region and thigh)
0.000 0.625 0.375
M25.99 Joint disorder, unspecified (Site unspecified)
0.000 0.625 0.375
M34.1 CR(E)ST syndrome
0.000 0.628 0.372
M34.9 Systemic sclerosis, unspecified
0.000 0.629 0.371
M07.31 Other psoriatic arthropathies (Shoulder region)
0.370 0.630 0.000
M25.86 Other specified joint disorders (Lower leg)
0.000 0.631 0.369
M25.68 Stiffness of joint, not elsewhere classified (Other)
0.000 0.632 0.367
M25.62 Stiffness of joint, not elsewhere classified (Upper arm)
0.000 0.636 0.364
M30.1 Polyarteritis with lung involvement [Churg-Strauss]
0.000 0.636 0.363
M25.95 Joint disorder, unspecified (Pelvic region and thigh)
0.000 0.639 0.361
M21.19 Varus deformity, not elsewhere classified (Site unspecified)
0.000 0.639 0.360
M21.18 Varus deformity, not elsewhere classified (Other)
0.000 0.639 0.360
M21.15 Varus deformity, not elsewhere classified (Pelvic region and thigh)
0.000 0.639 0.360
M21.14 Varus deformity, not elsewhere classified (Hand)
0.000 0.639 0.360
M21.13 Varus deformity, not elsewhere classified (Forearm)
0.000 0.639 0.360
M21.12 Varus deformity, not elsewhere classified (Upper arm)
0.000 0.639 0.360
M21.11 Varus deformity, not elsewhere classified (Shoulder region)
0.000 0.639 0.360
M21.10 Varus deformity, not elsewhere classified (Multiple sites)
0.000 0.639 0.360
E22.0 Acromegaly and pituitary gigantism
0.000 0.640 0.360
E34.0 Carcinoid syndrome
0.000 0.643 0.357
M25.98 Joint disorder, unspecified (Other)
0.000 0.643 0.357
M25.92 Joint disorder, unspecified (Upper arm)
0.000 0.643 0.357
M25.90 Joint disorder, unspecified (Multiple sites)
0.000 0.643 0.357
M25.81 Other specified joint disorders (Shoulder region)
0.000 0.644 0.355
M25.91 Joint disorder, unspecified (Shoulder region)
0.000 0.647 0.353
M21.6 Other acquired deformities of ankle and foot
0.000 0.647 0.353
M34.2 Systemic sclerosis induced by drugs and chemicals
0.000 0.648 0.352
M34.0 Progressive systemic sclerosis
0.000 0.648 0.352
M24.16 Other articular cartilage disorders (Lower leg)
0.000 0.648 0.352
M25.69 Stiffness of joint, not elsewhere classified (Site unspecified)
0.000 0.651 0.349
M25.60 Stiffness of joint, not elsewhere classified (Multiple sites)
0.000 0.651 0.349
M30.0 Polyarteritis nodosa
0.000 0.655 0.345
M07.33 Other psoriatic arthropathies (Forearm)
0.345 0.655 0.000
M07.32 Other psoriatic arthropathies (Upper arm)
0.345 0.655 0.000
M25.93 Joint disorder, unspecified (Forearm)
0.000 0.656 0.344
E04.2 Non-toxic multinodular goitre
0.000 0.656 0.344
M24.4 Recurrent dislocation and subluxation of joint
0.000 0.657 0.343
M21.09 Valgus deformity, not elsewhere classified (Site unspecified)
0.000 0.657 0.343
M21.08 Valgus deformity, not elsewhere classified (Other)
0.000 0.657 0.343
M21.05 Valgus deformity, not elsewhere classified (Pelvic region and thigh)
0.000 0.657 0.343
M21.04 Valgus deformity, not elsewhere classified (Hand)
0.000 0.657 0.343
M21.03 Valgus deformity, not elsewhere classified (Forearm)
0.000 0.657 0.343
M21.02 Valgus deformity, not elsewhere classified (Upper arm)
0.000 0.657 0.343
M21.01 Valgus deformity, not elsewhere classified (Shoulder region)
0.000 0.657 0.343
M21.00 Valgus deformity, not elsewhere classified (Multiple sites)
0.000 0.657 0.343
E34.8 Other specified endocrine disorders
0.000 0.658 0.342
E22.1 Hyperprolactinaemia
0.000 0.658 0.342
E46 Unspecified protein-energy malnutrition
0.000 0.659 0.341
M35.99 Systemic involvement of connective tissue, unspecified, Site unspecified
0.000 0.660 0.340
M25.53 Pain in joint (Forearm)
0.000 0.662 0.338
M25.09 Haemarthrosis (Site unspecified)
0.000 0.664 0.336
M25.08 Haemarthrosis (Other)
0.000 0.664 0.336
M25.07 Haemarthrosis (Ankle and foot)
0.000 0.664 0.336
M25.05 Haemarthrosis (Pelvic region and thigh)
0.000 0.664 0.336
M25.04 Haemarthrosis (Hand)
0.000 0.664 0.336
M25.03 Haemarthrosis (Forearm)
0.000 0.664 0.336
M25.02 Haemarthrosis (Upper arm)
0.000 0.664 0.336
M25.01 Haemarthrosis (Shoulder region)
0.000 0.664 0.336
M25.00 Haemarthrosis (Multiple sites)
0.000 0.664 0.336
M21.47 Flat foot [pes planus] (acquired)-Ankle/foot
0.000 0.666 0.334
M25.65 Stiffness of joint, not elsewhere classified (Pelvic region and thigh)
0.000 0.667 0.333
M31.1 Thrombotic microangiopathy
0.000 0.667 0.333
M25.89 Other specified joint disorders (Site unspecified)
0.000 0.668 0.332
M25.80 Other specified joint disorders (Multiple sites)
0.000 0.668 0.332
M24.15 Other articular cartilage disorders (Pelvic region and thigh)
0.000 0.668 0.332
M22.9 Disorder of patella, unspecified
0.000 0.669 0.331
E61.1 Iron deficiency
0.000 0.669 0.330
M30.8 Other conditions related to polyarteritis nodosa
0.000 0.671 0.329
M30.3 Mucocutaneous lymph node syndrome [Kawasaki]
0.000 0.671 0.329
M30.2 Juvenile polyarteritis
0.000 0.671 0.329
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.672 0.328
E32 Diseases of thymus
0.000 0.672 0.328
E31 Polyglandular dysfunction
0.000 0.672 0.328
E30 Disorders of puberty, not elsewhere classified
0.000 0.672 0.328
M31.8 Other specified necrotising vasculopathies
0.000 0.673 0.327
M31.4 Aortic arch syndrome [Takayasu]
0.000 0.673 0.327
M31.2 Lethal midline granuloma
0.000 0.673 0.327
E07.9 Disorder of thyroid, unspecified
0.000 0.674 0.325
M31.9 Necrotising vasculopathy, unspecified
0.000 0.676 0.324
M31.0 Hypersensitivity angiitis
0.000 0.678 0.322
M25.97 Joint disorder, unspecified (Ankle and foot)
0.000 0.679 0.321
K90.8 Other intestinal malabsorption
0.000 0.681 0.319
M32.9 Systemic lupus erythematosus, unspecified
0.000 0.682 0.318
M32.0 Drug-induced systemic lupus erythematosus
0.000 0.682 0.318
E44.1 Mild protein-energy malnutrition
0.000 0.683 0.317
E44.0 Moderate protein-energy malnutrition
0.000 0.683 0.317
E26 Hyperaldosteronism
0.000 0.683 0.317
M21.73 Unequal limb length (acquired) (Forearm)
0.000 0.686 0.313
M21.5 Acquired clawhand, clubhand, clawfoot and clubfoot
0.000 0.688 0.312
M25.50 Pain in joint (Multiple sites)
0.000 0.688 0.312
M21.79 Unequal limb length (acquired) (Site unspecified)
0.000 0.688 0.312
M21.78 Unequal limb length (acquired)-Other
0.000 0.688 0.312
M21.77 Unequal limb length (acquired) (Ankle and foot)
0.000 0.688 0.312
M21.74 Unequal limb length (acquired) (Hand)
0.000 0.688 0.312
M21.72 Unequal limb length (acquired) (Upper arm)
0.000 0.688 0.312
M21.71 Unequal limb length (acquired)-Shldr region
0.000 0.688 0.312
M21.70 Unequal limb length (acquired) (Multiple sites)
0.000 0.688 0.312
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.000 0.691 0.309
M24.2 Disorder of ligament
0.000 0.691 0.309
E34.9 Endocrine disorder, unspecified
0.000 0.693 0.307
K90.3 Pancreatic steatorrhoea
0.000 0.693 0.307
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.693 0.307
K90.1 Tropical sprue
0.000 0.693 0.307
E20 Hypoparathyroidism
0.000 0.695 0.305
M21.3 Wrist or foot drop (acquired)
0.000 0.695 0.305
M25.82 Other specified joint disorders (Upper arm)
0.000 0.696 0.304
M21.49 Flat foot [pes planus] (acquired)-Site unspec
0.000 0.701 0.299
M21.48 Flat foot [pes planus] (acquired)-Other
0.000 0.701 0.299
M21.46 Flat foot [pes planus] (acquired)-Lower leg
0.000 0.701 0.299
M21.45 Flat foot [pes planus] (acquired)-Pelvic/thigh
0.000 0.701 0.299
M21.44 Flat foot [pes planus] (acquired)-Hand
0.000 0.701 0.299
M21.43 Flat foot [pes planus] (acquired)-Forearm
0.000 0.701 0.299
M21.42 Flat foot [pes planus] (acquired)-Upper arm
0.000 0.701 0.299
M21.41 Flat foot [pes planus] (acquired)-Shldr region
0.000 0.701 0.299
M21.40 Flat foot [pes planus] (acquired)-Mult sites
0.000 0.701 0.299
M22.1 Recurrent subluxation of patella
0.000 0.701 0.298
M25.83 Other specified joint disorders (Forearm)
0.000 0.703 0.297
E34.5 Androgen resistance syndrome
0.000 0.703 0.296
E34.4 Constitutional tall stature
0.000 0.703 0.296
E34.3 Short stature, not elsewhere classified
0.000 0.703 0.296
E34.2 Ectopic hormone secretion, not elsewhere classified
0.000 0.703 0.296
E34.1 Other hypersecretion of intestinal hormones
0.000 0.703 0.296
E29 Testicular dysfunction
0.000 0.705 0.295
M24.9 Joint derangement, unspecified
0.000 0.707 0.293
E27.3 Drug-induced adrenocortical insufficiency
0.000 0.707 0.293
M33 Dermatopolymyositis
0.000 0.707 0.292
E27.5 Adrenomedullary hyperfunction
0.000 0.708 0.292
E27.0 Other adrenocortical overactivity
0.000 0.708 0.292
M24.41 Recurrent dislocation and subluxation of joint (Shoulder region)
0.000 0.709 0.291
M24.13 Other articular cartilage disorders (Forearm)
0.000 0.709 0.291
M36.4 Arthropathy in hypersensitivity reactions classified elsewhere
0.000 0.711 0.289
M36.3 Arthropathy in other blood disorders
0.000 0.711 0.289
M36.2 Haemophilic arthropathy
0.000 0.711 0.289
M36.1 Arthropathy in neoplastic disease
0.000 0.711 0.289
M36.0 Dermato(poly)myositis in neoplastic disease
0.000 0.711 0.289
M21.76 Unequal limb length (acquired) (Lower leg)
0.000 0.711 0.289
M24.5 Contracture of joint
0.000 0.712 0.288
M21.97 Acquired deformity of limb, unspecified (Ankle and foot)
0.000 0.713 0.287
L40-L45 Papulosquamous disorders
0.287 0.713 0.000
M25.19 Fistula of joint (Site unspecified)
0.000 0.713 0.286
M25.18 Fistula of joint (Other)
0.000 0.713 0.286
M25.17 Fistula of joint (Ankle and foot)
0.000 0.713 0.286
M25.16 Fistula of joint (Lower leg)
0.000 0.713 0.286
M25.15 Fistula of joint (Pelvic region and thigh)
0.000 0.713 0.286
M25.14 Fistula of joint (Hand)
0.000 0.713 0.286
M25.13 Fistula of joint (Forearm)
0.000 0.713 0.286
M25.12 Fistula of joint (Upper arm)
0.000 0.713 0.286
M25.11 Fistula of joint (Shoulder region)
0.000 0.713 0.286
M25.10 Fistula of joint (Multiple sites)
0.000 0.713 0.286
M25.29 Flail joint (Site unspecified)
0.000 0.713 0.286
M25.28 Flail joint (Other)
0.000 0.713 0.286
M25.27 Flail joint (Ankle and foot)
0.000 0.713 0.286
M25.26 Flail joint (Lower leg)
0.000 0.713 0.286
M25.25 Flail joint (Pelvic region and thigh)
0.000 0.713 0.286
M25.24 Flail joint (Hand)
0.000 0.713 0.286
M25.23 Flail joint (Forearm)
0.000 0.713 0.286
M25.22 Flail joint (Upper arm)
0.000 0.713 0.286
M25.21 Flail joint (Shoulder region)
0.000 0.713 0.286
M25.20 Flail joint (Multiple sites)
0.000 0.713 0.286
M24.0 Loose body in joint
0.000 0.714 0.286
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.714 0.286
E22.8 Other hyperfunction of pituitary gland
0.000 0.714 0.286
E14.9 Without complications
0.000 0.715 0.285
M07.36 Other psoriatic arthropathies (Lower leg)
0.282 0.718 0.000
K90.9 Intestinal malabsorption, unspecified
0.000 0.718 0.282
M36.8 Systemic disorders of connective tissue in other diseases classified elsewhere
0.000 0.719 0.281
M24.7 Protrusio acetabuli
0.000 0.719 0.281
M31.7 Microscopic polyangiitis
0.000 0.721 0.279
M21.99 Acquired deformity of limb, unspecified (Site unspecified)
0.000 0.725 0.275
M21.98 Acquired deformity of limb, unspecified-Other
0.000 0.725 0.275
M21.96 Acquired deformity of limb, unspecified (Lower leg)
0.000 0.725 0.275
M21.95 Acquired deformity of limb, unspecified (Pelvic region and thigh)
0.000 0.725 0.275
M21.93 Acquired deformity of limb, unspecified (Forearm)
0.000 0.725 0.275
M21.92 Acquired deformity of limb, unspecified (Upper arm)
0.000 0.725 0.275
M21.91 Acquired deformity of limb, unspecified (Shoulder region)
0.000 0.725 0.275
M21.90 Acquired deformity of limb, unspecified (Multiple sites)
0.000 0.725 0.275
M21.89 Other specified acquired deformities of limbs (Site unspecified)
0.000 0.727 0.273
M21.88 Other specified acquired deformities of limbs-Other
0.000 0.727 0.273
M21.87 Other specified acquired deformities of limbs (Ankle and foot)
0.000 0.727 0.273
M21.86 Other specified acquired deformities of limbs (Lower leg)
0.000 0.727 0.273
M21.84 Other specified acquired deformities of limbs (Hand)
0.000 0.727 0.273
M21.83 Other specified acquired deformities of limbs (Forearm)
0.000 0.727 0.273
M21.82 Other specified acquired deformities of limbs (Upper arm)
0.000 0.727 0.273
M21.81 Other specified acquired deformities of limbs (Shoulder region)
0.000 0.727 0.273
M21.80 Other specified acquired deformities of limbs (Multiple sites)
0.000 0.727 0.273
M22.3 Other derangements of patella
0.000 0.727 0.273
M21.85 Other specified acquired deformities of limbs (Pelvic region and thigh)
0.000 0.728 0.272
M24.19 Other articular cartilage disorders (Site unspecified)
0.000 0.730 0.270
M24.18 Other articular cartilage disorders (Other)
0.000 0.730 0.270
M24.14 Other articular cartilage disorders (Hand)
0.000 0.730 0.270
M24.12 Other articular cartilage disorders (Upper arm)
0.000 0.730 0.270
M24.10 Other articular cartilage disorders (Multiple sites)
0.000 0.730 0.270
M25.67 Stiffness of joint, not elsewhere classified (Ankle and foot)
0.000 0.732 0.268
M25.88 Other specified joint disorders (Other)
0.000 0.734 0.266
M21.07 Valgus deformity, not elsewhere classified (Ankle and foot)
0.000 0.735 0.265
M24.3 Pathological dislocation and subluxation of joint, not elsewhere classified
0.000 0.735 0.265
M24.27 Disorder of ligament (Ankle and foot)
0.000 0.735 0.265
M21.94 Acquired deformity of limb, unspecified (Hand)
0.000 0.736 0.264
M24.44 Recurrent dislocation and subluxation of joint (Hand)
0.000 0.738 0.262
M32.8 Other forms of systemic lupus erythematosus
0.000 0.741 0.259
E25 Adrenogenital disorders
0.001 0.743 0.257
E04.1 Non-toxic single thyroid nodule
0.000 0.746 0.254
M21.69 Other acquired deformities of ankle and foot-Site unspec
0.000 0.747 0.253
M21.68 Other acquired deformities of ankle and foot-Other
0.000 0.747 0.253
M21.66 Other acquired deformities of ankle and foot-Lower leg
0.000 0.747 0.253
M21.65 Other acquired deformities of ankle and foot-Pelvic/thigh
0.000 0.747 0.253
M21.64 Other acquired deformities of ankle and foot-Hand
0.000 0.747 0.253
M21.63 Other acquired deformities of ankle and foot-Forearm
0.000 0.747 0.253
M21.62 Other acquired deformities of ankle and foot-Upper arm
0.000 0.747 0.253
M21.61 Other acquired deformities of ankle and foot-Shldr region
0.000 0.747 0.253
M21.60 Other acquired deformities of ankle and foot-Mult sites
0.000 0.747 0.253
M24.01 Loose body in joint (Shoulder region)
0.000 0.749 0.251
M25.63 Stiffness of joint, not elsewhere classified (Forearm)
0.000 0.750 0.250
E24 Cushing's syndrome
0.000 0.751 0.249
M24.49 Recurrent dislocation and subluxation of joint (Site unspecified)
0.000 0.754 0.246
M24.48 Recurrent dislocation and subluxation of joint (Other)
0.000 0.754 0.246
M24.46 Recurrent dislocation and subluxation of joint (Lower leg)
0.000 0.754 0.246
M24.43 Recurrent dislocation and subluxation of joint (Forearm)
0.000 0.754 0.246
M24.42 Recurrent dislocation and subluxation of joint (Upper arm)
0.000 0.754 0.246
M24.40 Recurrent dislocation and subluxation of joint (Multiple sites)
0.000 0.754 0.246
M25.4 Effusion of joint
0.000 0.754 0.245
E27.8 Other specified disorders of adrenal gland
0.000 0.756 0.244
M24.45 Recurrent dislocation and subluxation of joint (Pelvic region and thigh)
0.000 0.756 0.243
M24.47 Recurrent dislocation and subluxation of joint (Ankle and foot)
0.000 0.759 0.241
M22.0 Recurrent dislocation of patella
0.000 0.759 0.241
M24.11 Other articular cartilage disorders (Shoulder region)
0.000 0.760 0.239
M24.21 Disorder of ligament (Shoulder region)
0.000 0.761 0.239
E27.2 Addisonian crisis
0.000 0.762 0.238
M25.3 Other instability of joint
0.000 0.764 0.236
E30.9 Disorder of puberty, unspecified
0.000 0.765 0.235
E30.8 Other disorders of puberty
0.000 0.765 0.235
E30.1 Precocious puberty
0.000 0.765 0.235
E30.0 Delayed puberty
0.000 0.765 0.235
E31.9 Polyglandular dysfunction, unspecified
0.000 0.765 0.235
E31.8 Other polyglandular dysfunction
0.000 0.765 0.235
E31.1 Polyglandular hyperfunction
0.000 0.765 0.235
E31.0 Autoimmune polyglandular failure
0.000 0.765 0.235
E32.9 Disease of thymus, unspecified
0.000 0.765 0.235
E32.8 Other diseases of thymus
0.000 0.765 0.235
E32.1 Abscess of thymus
0.000 0.765 0.235
E32.0 Persistent hyperplasia of thymus
0.000 0.765 0.235
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.765 0.235

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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