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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs2535304
log Bayes Factor = 72.6831
Chromosome 6   position 31,054,687  (GRCh37) Explore rs2535304 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E03.9 Hypothyroidism, unspecified
1.000 0.000 0.000
K90.0 Coeliac disease
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
R31 Unspecified haematuria
1.000 0.000 0.000
E10-E14 Diabetes mellitus
0.000 0.000 1.000
L40.9 Psoriasis, unspecified
0.000 0.000 1.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.001 0.999
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.002 0.998
E16.2 Hypoglycaemia, unspecified
0.000 0.002 0.998
E16 Other disorders of pancreatic internal secretion
0.000 0.002 0.998
E10.1 With ketoacidosis
0.000 0.002 0.998
E10.9 Without complications
0.000 0.003 0.997
E10.3 With ophthalmic complications
0.000 0.006 0.994
D86.9 Sarcoidosis, unspecified
0.000 0.008 0.992
D86 Sarcoidosis
0.000 0.008 0.992
L40 Psoriasis
0.000 0.014 0.986
D80-D89 Certain disorders involving the immune mechanism
0.000 0.014 0.986
E00-E07 Disorders of thyroid gland
0.033 0.016 0.951
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.000 0.018 0.982
D70-D77 Other diseases of blood and blood-forming organs
0.000 0.023 0.977
D70 Agranulocytosis
0.000 0.026 0.974
L40.5 Arthropathic psoriasis
0.000 0.031 0.969
E05 Thyrotoxicosis [hyperthyroidism]
0.005 0.044 0.951
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.045 0.955
D50-D53 Nutritional anaemias
0.000 0.050 0.950
L40.0 Psoriasis vulgaris
0.000 0.058 0.942
D51 Vitamin B12 deficiency anaemia
0.000 0.068 0.932
E11 Non-insulin-dependent diabetes mellitus
0.000 0.076 0.924
D86.1 Sarcoidosis of lymph nodes
0.000 0.085 0.915
E10.2 With renal complications
0.000 0.104 0.896
E10.8 With unspecified complications
0.000 0.106 0.894
D51.0 Vitamin B12 deficiency anaemia due to intrinsic factor deficiency
0.000 0.111 0.889
E10.4 With neurological complications
0.000 0.137 0.863
E11.5 With peripheral circulatory complications
0.000 0.143 0.857
E50-E64 Other nutritional deficiencies
0.000 0.144 0.856
D51.9 Vitamin B12 deficiency anaemia, unspecified
0.000 0.148 0.852
D72 Other disorders of white blood cells
0.000 0.160 0.840
D86.0 Sarcoidosis of lung
0.000 0.161 0.839
E11.3 With ophthalmic complications
0.000 0.163 0.837
E10.5 With peripheral circulatory complications
0.000 0.176 0.824
E11.4 With neurological complications
0.000 0.181 0.819
E10.6 With other specified complications
0.000 0.184 0.815
D53 Other nutritional anaemias
0.000 0.187 0.813
D80 Immunodeficiency with predominantly antibody defects
0.000 0.191 0.809
E55 Vitamin D deficiency
0.000 0.194 0.806
D75 Other diseases of blood and blood-forming organs
0.000 0.198 0.802
D55-D59 Haemolytic anaemias
0.000 0.202 0.798
D86.8 Sarcoidosis of other and combined sites
0.000 0.207 0.793
D83 Common variable immunodeficiency
0.000 0.221 0.779
E55.9 Vitamin D deficiency, unspecified
0.000 0.230 0.770
D86.3 Sarcoidosis of skin
0.000 0.232 0.768
E10.0 With coma
0.000 0.234 0.765
E03 Other hypothyroidism
0.401 0.235 0.364
L40.4 Guttate psoriasis
0.000 0.238 0.762
D59 Acquired haemolytic anaemia
0.000 0.248 0.752
E11.8 With unspecified complications
0.000 0.249 0.751
D72.8 Other specified disorders of white blood cells
0.000 0.251 0.749
L40.1 Generalised pustular psoriasis
0.000 0.264 0.736
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions
0.000 0.265 0.735
E11.1 With ketoacidosis
0.000 0.266 0.734
D86.2 Sarcoidosis of lung with sarcoidosis of lymph nodes
0.000 0.267 0.733
E10.7 With multiple complications
0.000 0.283 0.717
E12 Malnutrition-related diabetes mellitus
0.000 0.283 0.717
E15 Nondiabetic hypoglycaemic coma
0.000 0.284 0.716
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.284 0.716
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.284 0.716
E16.4 Abnormal secretion of gastrin
0.000 0.284 0.716
E16.3 Increased secretion of glucagon
0.000 0.284 0.716
D53.9 Nutritional anaemia, unspecified
0.000 0.285 0.715
E13 Other specified diabetes mellitus
0.000 0.291 0.709
E14 Unspecified diabetes mellitus
0.000 0.291 0.709
L40.3 Pustulosis palmaris et plantaris
0.000 0.293 0.707
L40.2 Acrodermatitis continua
0.000 0.293 0.707
D81 Combined immunodeficiencies
0.000 0.293 0.707
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.024 0.294 0.682
E00 Congenital iodine-deficiency syndrome
0.024 0.294 0.682
D74 Methaemoglobinaemia
0.000 0.299 0.701
D77 Other disorders of blood and blood-forming organs in diseases classified elsewhere
0.000 0.299 0.701
D71 Functional disorders of polymorphonuclear neutrophils
0.000 0.299 0.701
E40-E46 Malnutrition
0.000 0.307 0.693
E11.6 With other specified complications
0.000 0.313 0.687
D75.9 Disease of blood and blood-forming organs, unspecified
0.000 0.313 0.687
E05.5 Thyroid crisis or storm
0.004 0.314 0.682
E05.4 Thyrotoxicosis factitia
0.004 0.314 0.682
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.004 0.314 0.682
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.004 0.314 0.682
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.314 0.685
E16.1 Other hypoglycaemia
0.000 0.316 0.684
E02 Subclinical iodine-deficiency hypothyroidism
0.023 0.318 0.659
D59.9 Acquired haemolytic anaemia, unspecified
0.000 0.320 0.680
D80.1 Nonfamilial hypogammaglobulinaemia
0.000 0.322 0.678
D82 Immunodeficiency associated with other major defects
0.000 0.323 0.677
E06 Thyroiditis
0.017 0.323 0.660
D51.8 Other vitamin B12 deficiency anaemias
0.000 0.332 0.668
D51.3 Other dietary vitamin B12 deficiency anaemia
0.000 0.332 0.668
D51.2 Transcobalamin II deficiency
0.000 0.332 0.668
D51.1 Vitamin B12 deficiency anaemia due to selective vitamin B12 malabsorption with proteinuria
0.000 0.332 0.668
E11.7 With multiple complications
0.000 0.337 0.663
D76 Certain diseases involving lymphoreticular tissue and reticulohistiocytic system
0.000 0.345 0.655
D59.1 Other autoimmune haemolytic anaemias
0.000 0.347 0.653
E53 Deficiency of other B group vitamins
0.000 0.348 0.652
E05.8 Other thyrotoxicosis
0.004 0.354 0.642
E51 Thiamine deficiency
0.000 0.356 0.644
D80.2 Selective deficiency of immunoglobulin A [IgA]
0.000 0.364 0.636
D83.9 Common variable immunodeficiency, unspecified
0.000 0.368 0.631
D75.0 Familial erythrocytosis
0.000 0.370 0.630
D80.3 Selective deficiency of immunoglobulin G [IgG] subclasses
0.000 0.372 0.628
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.386 0.613
E63 Other nutritional deficiencies
0.000 0.386 0.613
E50 Vitamin A deficiency
0.000 0.386 0.613
E60 Dietary zinc deficiency
0.000 0.386 0.613
E59 Dietary selenium deficiency
0.000 0.386 0.613
E52 Niacin deficiency [pellagra]
0.000 0.386 0.613
E14.3 With ophthalmic complications
0.000 0.396 0.604
D69 Purpura and other haemorrhagic conditions
0.000 0.397 0.603
D72.9 Disorder of white blood cells, unspecified
0.000 0.398 0.602
D72.0 Genetic anomalies of leukocytes
0.000 0.398 0.602
D66 Hereditary factor VIII deficiency
0.000 0.400 0.600
D84 Other immunodeficiencies
0.000 0.401 0.598
E83.1 Disorders of iron metabolism
0.000 0.407 0.593
E54 Ascorbic acid deficiency
0.000 0.410 0.589
D89 Other disorders involving the immune mechanism, not elsewhere classified
0.000 0.416 0.584
D75.2 Essential thrombocytosis
0.000 0.416 0.584
D53.8 Other specified nutritional anaemias
0.000 0.417 0.583
D53.2 Scorbutic anaemia
0.000 0.417 0.583
D53.1 Other megaloblastic anaemias, not elsewhere classified
0.000 0.417 0.583
D53.0 Protein deficiency anaemia
0.000 0.417 0.583
D72.1 Eosinophilia
0.000 0.419 0.581
D80.8 Other immunodeficiencies with predominantly antibody defects
0.000 0.420 0.580
D80.7 Transient hypogammaglobulinaemia of infancy
0.000 0.420 0.580
D80.6 Antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinaemia
0.000 0.420 0.580
D80.5 Immunodeficiency with increased immunoglobulin M [IgM]
0.000 0.420 0.580
D80.0 Hereditary hypogammaglobulinaemia
0.000 0.420 0.580
E55.0 Rickets, active
0.000 0.422 0.578
E06.9 Thyroiditis, unspecified
0.007 0.426 0.567
D55 Anaemia due to enzyme disorders
0.000 0.428 0.572
D50 Iron deficiency anaemia
0.000 0.428 0.572
D65 Disseminated intravascular coagulation [defibrination syndrome]
0.000 0.429 0.571
E58 Dietary calcium deficiency
0.000 0.435 0.565
E14.8 With unspecified complications
0.000 0.437 0.563
E70-E90 Metabolic disorders
0.000 0.437 0.563
D83.8 Other common variable immunodeficiencies
0.000 0.441 0.559
D83.2 Common variable immunodeficiency with autoantibodies to B- or T-cells
0.000 0.441 0.559
D83.1 Common variable immunodeficiency with predominant immunoregulatory T-cell disorders
0.000 0.441 0.559
D83.0 Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function
0.000 0.441 0.559
E56 Other vitamin deficiencies
0.000 0.441 0.559
E65-E68 Obesity and other hyperalimentation
0.000 0.444 0.556
E83 Disorders of mineral metabolism
0.000 0.446 0.554
E14.1 With ketoacidosis
0.000 0.451 0.549
E03.5 Myxoedema coma
0.288 0.452 0.261
E03.4 Atrophy of thyroid (acquired)
0.288 0.452 0.261
E03.3 Postinfectious hypothyroidism
0.288 0.452 0.261
E07 Other disorders of thyroid
0.047 0.452 0.502
D57 Sickle-cell disorders
0.000 0.454 0.545
D80.9 Immunodeficiency with predominantly antibody defects, unspecified
0.000 0.457 0.542
D75.8 Other specified diseases of blood and blood-forming organs
0.000 0.458 0.542
E03.0 Congenital hypothyroidism with diffuse goitre
0.285 0.461 0.254
D59.8 Other acquired haemolytic anaemias
0.000 0.461 0.539
D59.6 Haemoglobinuria due to haemolysis from other external causes
0.000 0.461 0.539
D59.5 Paroxysmal nocturnal haemoglobinuria [Marchiafava-Micheli]
0.000 0.461 0.539
D59.4 Other nonautoimmune haemolytic anaemias
0.000 0.461 0.539
D59.3 Haemolytic-uraemic syndrome
0.000 0.461 0.539
D59.2 Drug-induced nonautoimmune haemolytic anaemia
0.000 0.461 0.539
D59.0 Drug-induced autoimmune haemolytic anaemia
0.000 0.461 0.539
D67 Hereditary factor IX deficiency
0.000 0.462 0.538
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.004 0.462 0.534
E13.9 Without complications
0.000 0.465 0.535
E05.9 Thyrotoxicosis, unspecified
0.000 0.465 0.534
E03.1 Congenital hypothyroidism without goitre
0.253 0.467 0.279
E20-E35 Disorders of other endocrine glands
0.000 0.474 0.526
L40.8 Other psoriasis
0.000 0.476 0.524
E14.6 With other specified complications
0.000 0.477 0.523
E27.1 Primary adrenocortical insufficiency
0.000 0.479 0.521
E27 Other disorders of adrenal gland
0.000 0.482 0.518
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.298 0.483 0.219
E12.9 Without complications
0.000 0.486 0.514
E12.8 With unspecified complications
0.000 0.486 0.514
E12.7 With multiple complications
0.000 0.486 0.514
E12.6 With other specified complications
0.000 0.486 0.514
E12.5 With peripheral circulatory complications
0.000 0.486 0.514
E12.4 With neurological complications
0.000 0.486 0.514
E12.3 With ophthalmic complications
0.000 0.486 0.514
E12.2 With renal complications
0.000 0.486 0.514
E12.1 With ketoacidosis
0.000 0.486 0.514
E12.0 With coma
0.000 0.486 0.514
E88 Other metabolic disorders
0.000 0.486 0.514
D58 Other hereditary haemolytic anaemias
0.000 0.489 0.510
E13.8 With unspecified complications
0.000 0.491 0.508
E13.7 With multiple complications
0.000 0.491 0.508
E13.6 With other specified complications
0.000 0.491 0.508
E13.5 With peripheral circulatory complications
0.000 0.491 0.508
E13.4 With neurological complications
0.000 0.491 0.508
E13.2 With renal complications
0.000 0.491 0.508
E13.1 With ketoacidosis
0.000 0.491 0.508
E13.0 With coma
0.000 0.491 0.508
E14.7 With multiple complications
0.000 0.492 0.508
E14.2 Withrenal complications
0.000 0.492 0.508
E14.0 With coma
0.000 0.492 0.508
D69.6 Thrombocytopenia, unspecified
0.000 0.492 0.508
D75.1 Secondary polycythaemia
0.000 0.493 0.507
D81.9 Combined immunodeficiency, unspecified
0.000 0.493 0.507
D81.8 Other combined immunodeficiencies
0.000 0.493 0.507
D81.7 Major histocompatibility complex class II deficiency
0.000 0.493 0.507
D81.6 Major histocompatibility complex class I deficiency
0.000 0.493 0.507
D81.5 Purine nucleoside phosphorylase [PNP] deficiency
0.000 0.493 0.507
D81.4 Nezelof's syndrome
0.000 0.493 0.507
D81.3 Adenosine deaminase [ADA] deficiency
0.000 0.493 0.507
D81.2 Severe combined immunodeficiency [SCID] with low or normal B-cell numbers
0.000 0.493 0.507
D81.1 Severe combined immunodeficiency [SCID] with low T- and B-cell numbers
0.000 0.493 0.507
D81.0 Severe combined immunodeficiency [SCID] with reticular dysgenesis
0.000 0.493 0.507
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.017 0.494 0.489
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.017 0.494 0.489
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.017 0.494 0.489
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.017 0.494 0.489
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.017 0.494 0.489
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.017 0.494 0.489
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.017 0.494 0.489
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.017 0.494 0.489
D69.2 Other nonthrombocytopenic purpura
0.000 0.496 0.504
D74.9 Methaemoglobinaemia, unspecified
0.000 0.497 0.502
D74.8 Other methaemoglobinaemias
0.000 0.497 0.502
D74.0 Congenital methaemoglobinaemia
0.000 0.497 0.502
E53.9 Vitamin B deficiency, unspecified
0.000 0.498 0.502
E85 Amyloidosis
0.000 0.502 0.498
D69.5 Secondary thrombocytopenia
0.000 0.502 0.498
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.503 0.497
E45 Retarded development following protein-energy malnutrition
0.000 0.503 0.497
E43 Unspecified severe protein-energy malnutrition
0.000 0.503 0.497
E42 Marasmic kwashiorkor
0.000 0.503 0.497
E41 Nutritional marasmus
0.000 0.503 0.497
E40 Kwashiorkor
0.000 0.503 0.497
D80.4 Selective deficiency of immunoglobulin M [IgM]
0.000 0.507 0.492
E51.2 Wernicke's encephalopathy
0.000 0.507 0.492
E03.8 Other specified hypothyroidism
0.255 0.513 0.232
D82.9 Immunodeficiency associated with major defect, unspecified
0.000 0.514 0.485
D82.8 Immunodeficiency associated with other specified major defects
0.000 0.514 0.485
D82.4 Hyperimmunoglobulin E [IgE] syndrome
0.000 0.514 0.485
D82.3 Immunodeficiency following hereditary defective response to Epstein-Barr virus
0.000 0.514 0.485
D82.2 Immunodeficiency with short-limbed stature
0.000 0.514 0.485
D82.0 Wiskott-Aldrich syndrome
0.000 0.514 0.485
E06.4 Drug-induced thyroiditis
0.012 0.515 0.473
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.012 0.515 0.473
E06.0 Acute thyroiditis
0.012 0.515 0.473
E46 Unspecified protein-energy malnutrition
0.000 0.527 0.473
E53.8 Deficiency of other specified B group vitamins
0.000 0.528 0.472
E88.0 Disorders of plasma-protein metabolism, not elsewhere classified
0.000 0.529 0.471
E14.5 With peripheral circulatory complications
0.000 0.530 0.470
D76.2 Haemophagocytic syndrome, infection-associated
0.000 0.530 0.470
D76.1 Haemophagocytic lymphohistiocytosis
0.000 0.530 0.470
D76.0 Langerhans' cell histiocytosis, not elsewhere classified
0.000 0.530 0.470
E13.3 With ophthalmic complications
0.000 0.531 0.469
D84.1 Defects in the complement system
0.000 0.531 0.468
E53.1 Pyridoxine deficiency
0.000 0.532 0.468
E53.0 Riboflavin deficiency
0.000 0.532 0.468
K90 Intestinal malabsorption
0.000 0.535 0.465
E04 Other non-toxic goitre
0.002 0.535 0.463
D52 Folate deficiency anaemia
0.000 0.536 0.464
E51.9 Thiamine deficiency, unspecified
0.000 0.538 0.462
E51.8 Other manifestations of thiamine deficiency
0.000 0.538 0.462
E51.1 Beriberi
0.000 0.538 0.462
D50.9 Iron deficiency anaemia, unspecified
0.000 0.540 0.460
D69.3 Idiopathic thrombocytopenic purpura
0.000 0.542 0.458
D82.1 Di George's syndrome
0.000 0.544 0.456
E06.3 Autoimmune thyroiditis
0.006 0.545 0.448
E85.4 Organ-limited amyloidosis
0.000 0.552 0.448
E14.4 With neurological complications
0.000 0.552 0.447
D69.9 Haemorrhagic condition, unspecified
0.000 0.554 0.446
D89.8 Other specified disorders involving the immune mechanism, not elsewhere classified
0.000 0.556 0.444
E34 Other endocrine disorders
0.000 0.557 0.443
E50.9 Vitamin A deficiency, unspecified
0.000 0.560 0.440
E50.8 Other manifestations of vitamin A deficiency
0.000 0.560 0.440
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.560 0.440
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.560 0.440
E50.5 Vitamin A deficiency with night blindness
0.000 0.560 0.440
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.560 0.440
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.560 0.440
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.560 0.440
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.560 0.440
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.560 0.440
E63.9 Nutritional deficiency, unspecified
0.000 0.560 0.440
E63.8 Other specified nutritional deficiencies
0.000 0.560 0.440
E63.1 Imbalance of constituents of food intake
0.000 0.560 0.440
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.560 0.440
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.560 0.440
E64.8 Sequelae of other nutritional deficiencies
0.000 0.560 0.440
E64.3 Sequelae of rickets
0.000 0.560 0.440
E64.2 Sequelae of vitamin C deficiency
0.000 0.560 0.440
E64.1 Sequelae of vitamin A deficiency
0.000 0.560 0.440
E64.0 Sequelae of protein-energy malnutrition
0.000 0.560 0.440
E61 Deficiency of other nutrient elements
0.000 0.562 0.438
D89.9 Disorder involving the immune mechanism, unspecified
0.000 0.566 0.434
D69.8 Other specified haemorrhagic conditions
0.000 0.567 0.433
D84.8 Other specified immunodeficiencies
0.000 0.571 0.429
D84.0 Lymphocyte function antigen-1 [LFA-1] defect
0.000 0.571 0.429
E07.8 Other specified disorders of thyroid
0.023 0.572 0.405
D50.8 Other iron deficiency anaemias
0.000 0.572 0.428
E79 Disorders of purine and pyrimidine metabolism
0.000 0.575 0.425
D76.3 Other histiocytosis syndromes
0.000 0.576 0.424
E06.1 Subacute thyroiditis
0.014 0.579 0.407
E70 Disorders of aromatic amino-acid metabolism
0.000 0.581 0.419
D89.3 Immune reconstitution syndrome
0.000 0.581 0.419
E11.0 With coma
0.000 0.581 0.418
E20 Hypoparathyroidism
0.000 0.586 0.414
E88.1 Lipodystrophy, not elsewhere classified
0.000 0.586 0.414
D55.9 Anaemia due to enzyme disorder, unspecified
0.000 0.590 0.410
D55.8 Other anaemias due to enzyme disorders
0.000 0.590 0.410
D55.3 Anaemia due to disorders of nucleotide metabolism
0.000 0.590 0.410
D55.2 Anaemia due to disorders of glycolytic enzymes
0.000 0.590 0.410
D55.1 Anaemia due to other disorders of glutathione metabolism
0.000 0.590 0.410
D55.0 Anaemia due to glucose-6-phosphate dehydrogenase [G6PD] deficiency
0.000 0.590 0.410
D50.1 Sideropenic dysphagia
0.000 0.590 0.410
D69.1 Qualitative platelet defects
0.000 0.590 0.409
D89.1 Cryoglobulinaemia
0.000 0.596 0.404
E77 Disorders of glycoprotein metabolism
0.000 0.596 0.404
E76 Disorders of glycosaminoglycan metabolism
0.000 0.596 0.404
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.000 0.596 0.404
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.000 0.596 0.404
E88.9 Metabolic disorder, unspecified
0.000 0.597 0.403
E56.9 Vitamin deficiency, unspecified
0.000 0.599 0.401
E56.8 Deficiency of other vitamins
0.000 0.599 0.401
E56.0 Deficiency of vitamin E
0.000 0.599 0.401
E06.5 Other chronic thyroiditis
0.014 0.600 0.386
E11.2 With renal complications
0.000 0.600 0.399
E67 Other hyperalimentation
0.000 0.601 0.399
E68 Sequelae of hyperalimentation
0.000 0.601 0.399
E27.3 Drug-induced adrenocortical insufficiency
0.000 0.602 0.398
E83.8 Other disorders of mineral metabolism
0.000 0.602 0.398
E83.2 Disorders of zinc metabolism
0.000 0.602 0.398
E83.0 Disorders of copper metabolism
0.000 0.602 0.398
E34.9 Endocrine disorder, unspecified
0.000 0.607 0.393
E07.1 Dyshormogenetic goitre
0.034 0.607 0.360
E07.0 Hypersecretion of calcitonin
0.034 0.607 0.360
D57.8 Other sickle-cell disorders
0.000 0.609 0.391
D57.3 Sickle-cell trait
0.000 0.609 0.391
D57.2 Double heterozygous sickling disorders
0.000 0.609 0.391
D57.0 Sickle-cell anaemia with crisis
0.000 0.609 0.391
E25 Adrenogenital disorders
0.000 0.610 0.390
E04.0 Non-toxic diffuse goitre
0.001 0.612 0.387
D69.4 Other primary thrombocytopenia
0.000 0.617 0.383
E83.9 Disorder of mineral metabolism, unspecified
0.000 0.618 0.382
K90.9 Intestinal malabsorption, unspecified
0.000 0.622 0.378
D58.2 Other haemoglobinopathies
0.000 0.622 0.378
E84 Cystic fibrosis
0.000 0.622 0.378
E85.3 Secondary systemic amyloidosis
0.000 0.622 0.378
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.623 0.377
E32 Diseases of thymus
0.000 0.623 0.377
E31 Polyglandular dysfunction
0.000 0.623 0.377
E30 Disorders of puberty, not elsewhere classified
0.000 0.623 0.377
E27.5 Adrenomedullary hyperfunction
0.000 0.628 0.372
E27.0 Other adrenocortical overactivity
0.000 0.628 0.372
E72 Other disorders of amino-acid metabolism
0.000 0.629 0.371
E27.2 Addisonian crisis
0.000 0.631 0.369
E66 Obesity
0.000 0.632 0.368
E88.3 Tumour lysis syndrome
0.000 0.633 0.367
D58.8 Other specified hereditary haemolytic anaemias
0.000 0.634 0.366
D58.1 Hereditary elliptocytosis
0.000 0.634 0.366
D57.1 Sickle-cell anaemia without crisis
0.000 0.635 0.364
E85.8 Other amyloidosis
0.000 0.643 0.357
E85.2 Heredofamilial amyloidosis, unspecified
0.000 0.643 0.357
E85.1 Neuropathic heredofamilial amyloidosis
0.000 0.643 0.357
E85.0 Nonneuropathic heredofamilial amyloidosis
0.000 0.643 0.357
E44.1 Mild protein-energy malnutrition
0.000 0.644 0.356
E44.0 Moderate protein-energy malnutrition
0.000 0.644 0.356
E34.0 Carcinoid syndrome
0.000 0.644 0.356
E04.9 Non-toxic goitre, unspecified
0.000 0.649 0.351
E88.8 Other specified metabolic disorders
0.000 0.650 0.349
D56 Thalassaemia
0.001 0.651 0.348
E56.1 Deficiency of vitamin K
0.000 0.654 0.346
D89.2 Hypergammaglobulinaemia, unspecified
0.000 0.654 0.346
E85.9 Amyloidosis, unspecified
0.000 0.654 0.346
D89.0 Polyclonal hypergammaglobulinaemia
0.000 0.655 0.345
E74 Other disorders of carbohydrate metabolism
0.000 0.655 0.345
E27.8 Other specified disorders of adrenal gland
0.000 0.658 0.342
D58.9 Hereditary haemolytic anaemia, unspecified
0.000 0.664 0.335
K90.3 Pancreatic steatorrhoea
0.000 0.666 0.334
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.666 0.334
K90.1 Tropical sprue
0.000 0.666 0.334
E20.9 Hypoparathyroidism, unspecified
0.000 0.666 0.334
E04.8 Other specified non-toxic goitre
0.002 0.666 0.332
D52.8 Other folate deficiency anaemias
0.000 0.667 0.333
D52.1 Drug-induced folate deficiency anaemia
0.000 0.667 0.333
D52.0 Dietary folate deficiency anaemia
0.000 0.667 0.333
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
0.000 0.674 0.326
D58.0 Hereditary spherocytosis
0.000 0.675 0.324
K90.8 Other intestinal malabsorption
0.000 0.678 0.322
E24 Cushing's syndrome
0.000 0.682 0.318
E34.5 Androgen resistance syndrome
0.000 0.682 0.318
E34.4 Constitutional tall stature
0.000 0.682 0.318
E34.2 Ectopic hormone secretion, not elsewhere classified
0.000 0.682 0.318
E34.1 Other hypersecretion of intestinal hormones
0.000 0.682 0.318
E73 Lactose intolerance
0.000 0.683 0.316
E70.3 Albinism
0.000 0.683 0.316
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.000 0.685 0.315
E88.2 Lipomatosis, not elsewhere classified
0.000 0.685 0.315
E61.9 Deficiency of nutrient element, unspecified
0.000 0.686 0.314
E61.8 Deficiency of other specified nutrient elements
0.000 0.686 0.314
E61.7 Deficiency of multiple nutrient elements
0.000 0.686 0.314
E61.6 Vanadium deficiency
0.000 0.686 0.314
E61.5 Molybdenum deficiency
0.000 0.686 0.314
E61.4 Chromium deficiency
0.000 0.686 0.314
E61.3 Manganese deficiency
0.000 0.686 0.314
E61.0 Copper deficiency
0.000 0.686 0.314
E66.2 Extreme obesity with alveolar hypoventilation
0.000 0.686 0.314
E27.4 Other and unspecified adrenocortical insufficiency
0.000 0.689 0.311
E22 Hyperfunction of pituitary gland
0.000 0.691 0.309
E66.0 Obesity due to excess calories
0.000 0.694 0.306
E34.3 Short stature, not elsewhere classified
0.000 0.694 0.305
E79.9 Disorder of purine and pyrimidine metabolism, unspecified
0.000 0.695 0.305
E79.8 Other disorders of purine and pyrimidine metabolism
0.000 0.695 0.305
E79.1 Lesch-Nyhan syndrome
0.000 0.695 0.305
D60-D64 Aplastic and other anaemias
0.000 0.696 0.304
E70.9 Disorder of aromatic amino-acid metabolism, unspecified
0.000 0.699 0.301
E70.8 Other disorders of aromatic amino-acid metabolism
0.000 0.699 0.301
E70.2 Disorders of tyrosine metabolism
0.000 0.699 0.301
E70.1 Other hyperphenylalaninaemias
0.000 0.699 0.301
E70.0 Classical phenylketonuria
0.000 0.699 0.301
E29 Testicular dysfunction
0.000 0.700 0.300
E20.8 Other hypoparathyroidism
0.000 0.703 0.297
E20.1 Pseudohypoparathyroidism
0.000 0.703 0.297
E20.0 Idiopathic hypoparathyroidism
0.000 0.703 0.297
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.000 0.704 0.296
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.000 0.707 0.293
E65 Localised adiposity
0.000 0.709 0.290
S64.4 Injury of digital nerve of other finger
0.290 0.710 0.000
E71.3 Disorders of fatty-acid metabolism
0.000 0.710 0.289
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified
0.000 0.710 0.289
E71.1 Other disorders of branched-chain amino-acid metabolism
0.000 0.710 0.289
E71.0 Maple-syrup-urine disease
0.000 0.710 0.289
E76.9 Disorder of glucosaminoglycan metabolism, unspecified
0.000 0.710 0.289
E76.8 Other disorders of glucosaminoglycan metabolism
0.000 0.710 0.289
E76.3 Mucopolysaccharidosis, unspecified
0.000 0.710 0.289
E76.2 Other mucopolysaccharidoses
0.000 0.710 0.289
E76.1 Mucopolysaccharidosis, type II
0.000 0.710 0.289
E76.0 Mucopolysaccharidosis, type I
0.000 0.710 0.289
E77.9 Disorder of glycoprotein metabolism, unspecified
0.000 0.710 0.289
E77.8 Other disorders of glycoprotein metabolism
0.000 0.710 0.289
E77.1 Defects in glycoprotein degradation
0.000 0.710 0.289
E77.0 Defects in posttranslational modification of lysosomal enzymes
0.000 0.710 0.289
E86 Volume depletion
0.000 0.711 0.289
E67.8 Other specified hyperalimentation
0.000 0.714 0.286
E67.3 Hypervitaminosis D
0.000 0.714 0.286
E67.2 Megavitamin-B6 syndrome
0.000 0.714 0.286
E67.1 Hypercarotenaemia
0.000 0.714 0.286
E67.0 Hypervitaminosis A
0.000 0.714 0.286
E25.9 Adrenogenital disorder, unspecified
0.000 0.720 0.280
E25.8 Other adrenogenital disorders
0.000 0.720 0.280
E61.2 Magnesium deficiency
0.000 0.723 0.277
E84.8 Cystic fibrosis with other manifestations
0.000 0.729 0.271
E84.1 Cystic fibrosis with intestinal manifestations
0.000 0.729 0.271
E84.0 Cystic fibrosis with pulmonary manifestations
0.000 0.729 0.271
E30.9 Disorder of puberty, unspecified
0.000 0.729 0.271
E30.8 Other disorders of puberty
0.000 0.729 0.271
E30.1 Precocious puberty
0.000 0.729 0.271
E30.0 Delayed puberty
0.000 0.729 0.271
E31.9 Polyglandular dysfunction, unspecified
0.000 0.729 0.271
E31.8 Other polyglandular dysfunction
0.000 0.729 0.271
E31.1 Polyglandular hyperfunction
0.000 0.729 0.271
E31.0 Autoimmune polyglandular failure
0.000 0.729 0.271
E32.9 Disease of thymus, unspecified
0.000 0.729 0.271
E32.8 Other diseases of thymus
0.000 0.729 0.271
E32.1 Abscess of thymus
0.000 0.729 0.271
E32.0 Persistent hyperplasia of thymus
0.000 0.729 0.271
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.729 0.271
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.729 0.271
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.729 0.271
D73 Diseases of spleen
0.000 0.731 0.269
E72.9 Disorder of amino-acid metabolism, unspecified
0.000 0.734 0.266
E72.8 Other specified disorders of amino-acid metabolism
0.000 0.734 0.266
E72.5 Disorders of glycine metabolism
0.000 0.734 0.266
E72.4 Disorders of ornithine metabolism
0.000 0.734 0.266
E72.3 Disorders of lysine and hydroxylysine metabolism
0.000 0.734 0.266
E72.2 Disorders of urea cycle metabolism
0.000 0.734 0.266
E72.1 Disorders of sulphur-bearing amino-acid metabolism
0.000 0.734 0.266
E26 Hyperaldosteronism
0.000 0.736 0.264
E66.1 Drug-induced obesity
0.000 0.736 0.264
E34.8 Other specified endocrine disorders
0.000 0.749 0.251
D56.9 Thalassaemia, unspecified
0.001 0.749 0.249
D56.8 Other thalassaemias
0.001 0.749 0.249
D56.4 Hereditary persistence of foetal haemoglobin [HPFH]
0.001 0.749 0.249
D56.2 Delta-beta thalassaemia
0.001 0.749 0.249
D56.0 Alpha thalassaemia
0.001 0.749 0.249
E74.9 Disorder of carbohydrate metabolism, unspecified
0.000 0.752 0.247
E74.8 Other specified disorders of carbohydrate metabolism
0.000 0.752 0.247
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
0.000 0.752 0.247
E74.2 Disorders of galactose metabolism
0.000 0.752 0.247
E74.1 Disorders of fructose metabolism
0.000 0.752 0.247
E74.0 Glycogen storage disease
0.000 0.752 0.247
E24.0 Pituitary-dependent Cushing's disease
0.000 0.753 0.247
E84.9 Cystic fibrosis, unspecified
0.000 0.754 0.246
E22.1 Hyperprolactinaemia
0.000 0.759 0.241
E27.9 Disorder of adrenal gland, unspecified
0.000 0.760 0.240
E66.8 Other obesity
0.000 0.761 0.239
D84.9 Immunodeficiency, unspecified
0.001 0.763 0.236
E72.0 Disorders of amino-acid transport
0.000 0.767 0.233
E14.9 Without complications
0.000 0.768 0.232
E80 Disorders of porphyrin and bilirubin metabolism
0.000 0.770 0.230
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.000 0.772 0.228
E24.3 Ectopic ACTH syndrome
0.000 0.772 0.228
E24.1 Nelson's syndrome
0.000 0.772 0.228
E73.8 Other lactose intolerance
0.000 0.773 0.227

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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