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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs2535306
log Bayes Factor = 72.2171
Chromosome 6   position 31,053,867  (GRCh37) Explore rs2535306 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E03.9 Hypothyroidism, unspecified
1.000 0.000 0.000
K90.0 Coeliac disease
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
R31 Unspecified haematuria
1.000 0.000 0.000
L40.9 Psoriasis, unspecified
0.000 0.000 1.000
E10-E14 Diabetes mellitus
0.000 0.001 0.999
E10.1 With ketoacidosis
0.000 0.003 0.997
E16.2 Hypoglycaemia, unspecified
0.000 0.003 0.997
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.003 0.997
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.004 0.996
E16 Other disorders of pancreatic internal secretion
0.000 0.004 0.996
E10.9 Without complications
0.000 0.004 0.996
E10.3 With ophthalmic complications
0.000 0.006 0.994
L40 Psoriasis
0.000 0.006 0.994
L40.5 Arthropathic psoriasis
0.000 0.018 0.982
D86 Sarcoidosis
0.000 0.023 0.977
D86.9 Sarcoidosis, unspecified
0.000 0.023 0.977
D80-D89 Certain disorders involving the immune mechanism
0.000 0.030 0.970
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.000 0.034 0.966
E00-E07 Disorders of thyroid gland
0.054 0.036 0.910
D70-D77 Other diseases of blood and blood-forming organs
0.000 0.039 0.961
D70 Agranulocytosis
0.000 0.043 0.957
L40.0 Psoriasis vulgaris
0.000 0.050 0.950
D50-D53 Nutritional anaemias
0.000 0.054 0.946
D51 Vitamin B12 deficiency anaemia
0.000 0.064 0.936
E10.2 With renal complications
0.000 0.079 0.921
E05 Thyrotoxicosis [hyperthyroidism]
0.009 0.085 0.906
D51.0 Vitamin B12 deficiency anaemia due to intrinsic factor deficiency
0.000 0.087 0.913
E11 Non-insulin-dependent diabetes mellitus
0.000 0.090 0.910
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.090 0.910
D86.1 Sarcoidosis of lymph nodes
0.000 0.102 0.898
E10.8 With unspecified complications
0.000 0.110 0.890
E10.4 With neurological complications
0.000 0.137 0.863
E10.5 With peripheral circulatory complications
0.000 0.149 0.851
E11.5 With peripheral circulatory complications
0.000 0.150 0.850
D51.9 Vitamin B12 deficiency anaemia, unspecified
0.000 0.157 0.843
D72 Other disorders of white blood cells
0.000 0.173 0.827
E10.6 With other specified complications
0.000 0.190 0.810
D86.0 Sarcoidosis of lung
0.000 0.191 0.809
D53 Other nutritional anaemias
0.000 0.194 0.806
D75 Other diseases of blood and blood-forming organs
0.000 0.201 0.799
E11.3 With ophthalmic complications
0.000 0.201 0.799
L40.1 Generalised pustular psoriasis
0.000 0.201 0.799
E11.4 With neurological complications
0.000 0.220 0.780
D80 Immunodeficiency with predominantly antibody defects
0.000 0.221 0.779
D55-D59 Haemolytic anaemias
0.000 0.224 0.776
D86.8 Sarcoidosis of other and combined sites
0.000 0.228 0.772
L40.4 Guttate psoriasis
0.000 0.234 0.766
E03 Other hypothyroidism
0.464 0.235 0.301
D83 Common variable immunodeficiency
0.000 0.236 0.764
E11.8 With unspecified complications
0.000 0.241 0.759
E10.0 With coma
0.000 0.241 0.759
D86.3 Sarcoidosis of skin
0.000 0.247 0.753
E50-E64 Other nutritional deficiencies
0.000 0.249 0.751
D86.2 Sarcoidosis of lung with sarcoidosis of lymph nodes
0.000 0.253 0.746
D72.8 Other specified disorders of white blood cells
0.000 0.266 0.734
D59 Acquired haemolytic anaemia
0.000 0.274 0.726
E10.7 With multiple complications
0.000 0.283 0.717
E12 Malnutrition-related diabetes mellitus
0.000 0.284 0.716
E15 Nondiabetic hypoglycaemic coma
0.000 0.286 0.714
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.286 0.714
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.286 0.714
E16.4 Abnormal secretion of gastrin
0.000 0.286 0.714
E16.3 Increased secretion of glucagon
0.000 0.286 0.714
L40.3 Pustulosis palmaris et plantaris
0.000 0.287 0.712
L40.2 Acrodermatitis continua
0.000 0.287 0.712
E11.1 With ketoacidosis
0.000 0.292 0.708
D75.9 Disease of blood and blood-forming organs, unspecified
0.000 0.292 0.708
E13 Other specified diabetes mellitus
0.000 0.293 0.707
D53.9 Nutritional anaemia, unspecified
0.000 0.295 0.705
E14 Unspecified diabetes mellitus
0.000 0.295 0.705
D81 Combined immunodeficiencies
0.000 0.304 0.695
E40-E46 Malnutrition
0.000 0.309 0.691
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.039 0.309 0.652
E00 Congenital iodine-deficiency syndrome
0.039 0.309 0.652
D74 Methaemoglobinaemia
0.000 0.311 0.689
D77 Other disorders of blood and blood-forming organs in diseases classified elsewhere
0.000 0.311 0.689
D71 Functional disorders of polymorphonuclear neutrophils
0.000 0.311 0.689
E55 Vitamin D deficiency
0.000 0.313 0.687
E16.1 Other hypoglycaemia
0.000 0.324 0.676
D51.8 Other vitamin B12 deficiency anaemias
0.000 0.329 0.671
D51.3 Other dietary vitamin B12 deficiency anaemia
0.000 0.329 0.671
D51.2 Transcobalamin II deficiency
0.000 0.329 0.671
D51.1 Vitamin B12 deficiency anaemia due to selective vitamin B12 malabsorption with proteinuria
0.000 0.329 0.671
E83.1 Disorders of iron metabolism
0.000 0.332 0.668
E06 Thyroiditis
0.028 0.333 0.639
E02 Subclinical iodine-deficiency hypothyroidism
0.038 0.335 0.627
D82 Immunodeficiency associated with other major defects
0.000 0.336 0.664
E11.6 With other specified complications
0.000 0.337 0.663
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.343 0.656
E05.5 Thyroid crisis or storm
0.007 0.344 0.650
E05.4 Thyrotoxicosis factitia
0.007 0.344 0.650
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.007 0.344 0.650
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.007 0.344 0.650
D59.9 Acquired haemolytic anaemia, unspecified
0.000 0.346 0.654
E11.7 With multiple complications
0.000 0.347 0.653
D80.1 Nonfamilial hypogammaglobulinaemia
0.000 0.356 0.644
E55.9 Vitamin D deficiency, unspecified
0.000 0.358 0.642
D76 Certain diseases involving lymphoreticular tissue and reticulohistiocytic system
0.000 0.363 0.637
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions
0.000 0.368 0.632
D75.0 Familial erythrocytosis
0.000 0.375 0.625
D59.1 Other autoimmune haemolytic anaemias
0.000 0.377 0.623
E70-E90 Metabolic disorders
0.000 0.381 0.619
D83.9 Common variable immunodeficiency, unspecified
0.000 0.384 0.616
E05.8 Other thyrotoxicosis
0.007 0.386 0.607
E83 Disorders of mineral metabolism
0.000 0.387 0.613
D80.2 Selective deficiency of immunoglobulin A [IgA]
0.000 0.392 0.608
D80.3 Selective deficiency of immunoglobulin G [IgG] subclasses
0.000 0.399 0.601
D72.9 Disorder of white blood cells, unspecified
0.000 0.407 0.593
D72.0 Genetic anomalies of leukocytes
0.000 0.407 0.593
D72.1 Eosinophilia
0.000 0.414 0.586
D84 Other immunodeficiencies
0.000 0.416 0.584
D50 Iron deficiency anaemia
0.000 0.419 0.581
D53.8 Other specified nutritional anaemias
0.000 0.422 0.578
D53.2 Scorbutic anaemia
0.000 0.422 0.578
D53.1 Other megaloblastic anaemias, not elsewhere classified
0.000 0.422 0.578
D53.0 Protein deficiency anaemia
0.000 0.422 0.578
E14.8 With unspecified complications
0.000 0.426 0.574
E14.3 With ophthalmic complications
0.000 0.428 0.572
D75.2 Essential thrombocytosis
0.000 0.432 0.568
E06.9 Thyroiditis, unspecified
0.011 0.432 0.556
E51 Thiamine deficiency
0.000 0.436 0.564
L40.8 Other psoriasis
0.000 0.439 0.561
D80.8 Other immunodeficiencies with predominantly antibody defects
0.000 0.442 0.558
D80.7 Transient hypogammaglobulinaemia of infancy
0.000 0.442 0.558
D80.6 Antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinaemia
0.000 0.442 0.558
D80.5 Immunodeficiency with increased immunoglobulin M [IgM]
0.000 0.442 0.558
D80.0 Hereditary hypogammaglobulinaemia
0.000 0.442 0.558
E88 Other metabolic disorders
0.000 0.442 0.558
D55 Anaemia due to enzyme disorders
0.000 0.443 0.557
E03.5 Myxoedema coma
0.333 0.451 0.216
E03.4 Atrophy of thyroid (acquired)
0.333 0.451 0.216
E03.3 Postinfectious hypothyroidism
0.333 0.451 0.216
D83.8 Other common variable immunodeficiencies
0.000 0.452 0.548
D83.2 Common variable immunodeficiency with autoantibodies to B- or T-cells
0.000 0.452 0.548
D83.1 Common variable immunodeficiency with predominant immunoregulatory T-cell disorders
0.000 0.452 0.548
D83.0 Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function
0.000 0.452 0.548
E14.1 With ketoacidosis
0.000 0.457 0.543
E65-E68 Obesity and other hyperalimentation
0.000 0.458 0.542
E03.0 Congenital hypothyroidism with diffuse goitre
0.331 0.459 0.210
E85 Amyloidosis
0.000 0.460 0.540
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.462 0.538
E63 Other nutritional deficiencies
0.000 0.462 0.538
E50 Vitamin A deficiency
0.000 0.462 0.538
E60 Dietary zinc deficiency
0.000 0.462 0.538
E59 Dietary selenium deficiency
0.000 0.462 0.538
E52 Niacin deficiency [pellagra]
0.000 0.462 0.538
D89 Other disorders involving the immune mechanism, not elsewhere classified
0.000 0.462 0.538
E14.6 With other specified complications
0.000 0.464 0.536
E13.9 Without complications
0.000 0.466 0.534
E07 Other disorders of thyroid
0.063 0.467 0.469
D57 Sickle-cell disorders
0.000 0.470 0.530
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.348 0.473 0.179
E03.1 Congenital hypothyroidism without goitre
0.295 0.475 0.231
E53 Deficiency of other B group vitamins
0.000 0.477 0.523
D59.8 Other acquired haemolytic anaemias
0.000 0.479 0.520
D59.6 Haemoglobinuria due to haemolysis from other external causes
0.000 0.479 0.520
D59.5 Paroxysmal nocturnal haemoglobinuria [Marchiafava-Micheli]
0.000 0.479 0.520
D59.4 Other nonautoimmune haemolytic anaemias
0.000 0.479 0.520
D59.3 Haemolytic-uraemic syndrome
0.000 0.479 0.520
D59.2 Drug-induced nonautoimmune haemolytic anaemia
0.000 0.479 0.520
D59.0 Drug-induced autoimmune haemolytic anaemia
0.000 0.479 0.520
D80.9 Immunodeficiency with predominantly antibody defects, unspecified
0.000 0.480 0.520
E20-E35 Disorders of other endocrine glands
0.000 0.481 0.519
D75.8 Other specified diseases of blood and blood-forming organs
0.000 0.482 0.518
E54 Ascorbic acid deficiency
0.000 0.484 0.516
E12.9 Without complications
0.000 0.486 0.513
E12.8 With unspecified complications
0.000 0.486 0.513
E12.7 With multiple complications
0.000 0.486 0.513
E12.6 With other specified complications
0.000 0.486 0.513
E12.5 With peripheral circulatory complications
0.000 0.486 0.513
E12.4 With neurological complications
0.000 0.486 0.513
E12.3 With ophthalmic complications
0.000 0.486 0.513
E12.2 With renal complications
0.000 0.486 0.513
E12.1 With ketoacidosis
0.000 0.486 0.513
E12.0 With coma
0.000 0.486 0.513
D66 Hereditary factor VIII deficiency
0.000 0.490 0.510
D75.1 Secondary polycythaemia
0.000 0.493 0.507
E88.0 Disorders of plasma-protein metabolism, not elsewhere classified
0.000 0.493 0.507
E13.8 With unspecified complications
0.000 0.493 0.507
E13.7 With multiple complications
0.000 0.493 0.507
E13.6 With other specified complications
0.000 0.493 0.507
E13.5 With peripheral circulatory complications
0.000 0.493 0.507
E13.4 With neurological complications
0.000 0.493 0.507
E13.2 With renal complications
0.000 0.493 0.507
E13.1 With ketoacidosis
0.000 0.493 0.507
E13.0 With coma
0.000 0.493 0.507
E11.2 With renal complications
0.000 0.494 0.506
E27.1 Primary adrenocortical insufficiency
0.000 0.494 0.506
E27 Other disorders of adrenal gland
0.000 0.495 0.505
E14.7 With multiple complications
0.000 0.495 0.505
E14.2 Withrenal complications
0.000 0.495 0.505
E14.0 With coma
0.000 0.495 0.505
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.007 0.500 0.493
D81.9 Combined immunodeficiency, unspecified
0.000 0.501 0.499
D81.8 Other combined immunodeficiencies
0.000 0.501 0.499
D81.7 Major histocompatibility complex class II deficiency
0.000 0.501 0.499
D81.6 Major histocompatibility complex class I deficiency
0.000 0.501 0.499
D81.5 Purine nucleoside phosphorylase [PNP] deficiency
0.000 0.501 0.499
D81.4 Nezelof's syndrome
0.000 0.501 0.499
D81.3 Adenosine deaminase [ADA] deficiency
0.000 0.501 0.499
D81.2 Severe combined immunodeficiency [SCID] with low or normal B-cell numbers
0.000 0.501 0.499
D81.1 Severe combined immunodeficiency [SCID] with low T- and B-cell numbers
0.000 0.501 0.499
D81.0 Severe combined immunodeficiency [SCID] with reticular dysgenesis
0.000 0.501 0.499
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.504 0.496
E45 Retarded development following protein-energy malnutrition
0.000 0.504 0.496
E43 Unspecified severe protein-energy malnutrition
0.000 0.504 0.496
E42 Marasmic kwashiorkor
0.000 0.504 0.496
E41 Nutritional marasmus
0.000 0.504 0.496
E40 Kwashiorkor
0.000 0.504 0.496
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.028 0.504 0.468
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.028 0.504 0.468
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.028 0.504 0.468
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.028 0.504 0.468
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.028 0.504 0.468
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.028 0.504 0.468
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.028 0.504 0.468
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.028 0.504 0.468
D74.9 Methaemoglobinaemia, unspecified
0.000 0.506 0.494
D74.8 Other methaemoglobinaemias
0.000 0.506 0.494
D74.0 Congenital methaemoglobinaemia
0.000 0.506 0.494
E03.8 Other specified hypothyroidism
0.312 0.506 0.182
E58 Dietary calcium deficiency
0.000 0.506 0.494
E55.0 Rickets, active
0.000 0.507 0.493
E56 Other vitamin deficiencies
0.000 0.511 0.489
E05.9 Thyrotoxicosis, unspecified
0.000 0.511 0.489
D58 Other hereditary haemolytic anaemias
0.000 0.512 0.487
D65 Disseminated intravascular coagulation [defibrination syndrome]
0.000 0.513 0.487
E85.4 Organ-limited amyloidosis
0.000 0.518 0.482
E06.4 Drug-induced thyroiditis
0.020 0.521 0.458
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.020 0.521 0.458
E06.0 Acute thyroiditis
0.020 0.521 0.458
D82.9 Immunodeficiency associated with major defect, unspecified
0.000 0.523 0.476
D82.8 Immunodeficiency associated with other specified major defects
0.000 0.523 0.476
D82.4 Hyperimmunoglobulin E [IgE] syndrome
0.000 0.523 0.476
D82.3 Immunodeficiency following hereditary defective response to Epstein-Barr virus
0.000 0.523 0.476
D82.2 Immunodeficiency with short-limbed stature
0.000 0.523 0.476
D82.0 Wiskott-Aldrich syndrome
0.000 0.523 0.476
E46 Unspecified protein-energy malnutrition
0.000 0.527 0.473
D80.4 Selective deficiency of immunoglobulin M [IgM]
0.000 0.528 0.472
D52 Folate deficiency anaemia
0.000 0.533 0.466
E13.3 With ophthalmic complications
0.000 0.534 0.466
E79 Disorders of purine and pyrimidine metabolism
0.000 0.534 0.465
E14.5 With peripheral circulatory complications
0.000 0.535 0.465
E14.4 With neurological complications
0.000 0.537 0.462
D50.9 Iron deficiency anaemia, unspecified
0.000 0.538 0.462
D67 Hereditary factor IX deficiency
0.000 0.539 0.461
E70 Disorders of aromatic amino-acid metabolism
0.000 0.540 0.460
D76.2 Haemophagocytic syndrome, infection-associated
0.000 0.543 0.457
D76.1 Haemophagocytic lymphohistiocytosis
0.000 0.543 0.457
D76.0 Langerhans' cell histiocytosis, not elsewhere classified
0.000 0.543 0.457
D84.1 Defects in the complement system
0.000 0.544 0.456
D50.8 Other iron deficiency anaemias
0.000 0.547 0.453
D69 Purpura and other haemorrhagic conditions
0.000 0.548 0.452
E88.1 Lipodystrophy, not elsewhere classified
0.000 0.553 0.447
E34 Other endocrine disorders
0.000 0.553 0.447
D82.1 Di George's syndrome
0.000 0.555 0.445
E77 Disorders of glycoprotein metabolism
0.000 0.556 0.444
E76 Disorders of glycosaminoglycan metabolism
0.000 0.556 0.444
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.000 0.556 0.444
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.000 0.556 0.444
E04 Other non-toxic goitre
0.004 0.557 0.439
E83.8 Other disorders of mineral metabolism
0.000 0.560 0.440
E83.2 Disorders of zinc metabolism
0.000 0.560 0.440
E83.0 Disorders of copper metabolism
0.000 0.560 0.440
E06.3 Autoimmune thyroiditis
0.011 0.562 0.428
E88.9 Metabolic disorder, unspecified
0.000 0.564 0.436
E51.2 Wernicke's encephalopathy
0.000 0.570 0.429
E83.9 Disorder of mineral metabolism, unspecified
0.000 0.579 0.421
K90 Intestinal malabsorption
0.000 0.579 0.421
D84.8 Other specified immunodeficiencies
0.000 0.581 0.419
D84.0 Lymphocyte function antigen-1 [LFA-1] defect
0.000 0.581 0.419
D50.1 Sideropenic dysphagia
0.000 0.583 0.417
E06.1 Subacute thyroiditis
0.023 0.584 0.393
E20 Hypoparathyroidism
0.000 0.585 0.415
E84 Cystic fibrosis
0.000 0.585 0.415
D89.8 Other specified disorders involving the immune mechanism, not elsewhere classified
0.000 0.592 0.408
E85.3 Secondary systemic amyloidosis
0.000 0.592 0.408
E07.8 Other specified disorders of thyroid
0.032 0.593 0.375
E72 Other disorders of amino-acid metabolism
0.000 0.593 0.407
D76.3 Other histiocytosis syndromes
0.000 0.595 0.405
E51.9 Thiamine deficiency, unspecified
0.000 0.596 0.404
E51.8 Other manifestations of thiamine deficiency
0.000 0.596 0.404
E51.1 Beriberi
0.000 0.596 0.404
E11.0 With coma
0.000 0.599 0.400
E34.9 Endocrine disorder, unspecified
0.000 0.600 0.400
E53.9 Vitamin B deficiency, unspecified
0.000 0.600 0.400
D55.9 Anaemia due to enzyme disorder, unspecified
0.000 0.601 0.399
D55.8 Other anaemias due to enzyme disorders
0.000 0.601 0.399
D55.3 Anaemia due to disorders of nucleotide metabolism
0.000 0.601 0.399
D55.2 Anaemia due to disorders of glycolytic enzymes
0.000 0.601 0.399
D55.1 Anaemia due to other disorders of glutathione metabolism
0.000 0.601 0.399
D55.0 Anaemia due to glucose-6-phosphate dehydrogenase [G6PD] deficiency
0.000 0.601 0.399
D89.9 Disorder involving the immune mechanism, unspecified
0.000 0.603 0.397
E88.3 Tumour lysis syndrome
0.000 0.603 0.397
E06.5 Other chronic thyroiditis
0.023 0.604 0.372
E67 Other hyperalimentation
0.000 0.611 0.389
E68 Sequelae of hyperalimentation
0.000 0.611 0.389
E85.8 Other amyloidosis
0.000 0.612 0.387
E85.2 Heredofamilial amyloidosis, unspecified
0.000 0.612 0.387
E85.1 Neuropathic heredofamilial amyloidosis
0.000 0.612 0.387
E85.0 Nonneuropathic heredofamilial amyloidosis
0.000 0.612 0.387
E27.3 Drug-induced adrenocortical insufficiency
0.000 0.613 0.387
E50.9 Vitamin A deficiency, unspecified
0.000 0.614 0.386
E50.8 Other manifestations of vitamin A deficiency
0.000 0.614 0.386
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.614 0.386
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.614 0.386
E50.5 Vitamin A deficiency with night blindness
0.000 0.614 0.386
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.614 0.386
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.614 0.386
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.614 0.386
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.614 0.386
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.614 0.386
E63.9 Nutritional deficiency, unspecified
0.000 0.614 0.386
E63.8 Other specified nutritional deficiencies
0.000 0.614 0.386
E63.1 Imbalance of constituents of food intake
0.000 0.614 0.386
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.614 0.386
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.614 0.386
E64.8 Sequelae of other nutritional deficiencies
0.000 0.614 0.386
E64.3 Sequelae of rickets
0.000 0.614 0.386
E64.2 Sequelae of vitamin C deficiency
0.000 0.614 0.386
E64.1 Sequelae of vitamin A deficiency
0.000 0.614 0.386
E64.0 Sequelae of protein-energy malnutrition
0.000 0.614 0.386
D89.3 Immune reconstitution syndrome
0.000 0.614 0.386
E25 Adrenogenital disorders
0.000 0.616 0.383
E07.1 Dyshormogenetic goitre
0.046 0.618 0.337
E07.0 Hypersecretion of calcitonin
0.046 0.618 0.337
D57.8 Other sickle-cell disorders
0.000 0.620 0.380
D57.3 Sickle-cell trait
0.000 0.620 0.380
D57.2 Double heterozygous sickling disorders
0.000 0.620 0.380
D57.0 Sickle-cell anaemia with crisis
0.000 0.620 0.380
E88.8 Other specified metabolic disorders
0.000 0.623 0.377
D56 Thalassaemia
0.001 0.624 0.376
D69.2 Other nonthrombocytopenic purpura
0.000 0.624 0.376
E53.1 Pyridoxine deficiency
0.000 0.625 0.375
E53.0 Riboflavin deficiency
0.000 0.625 0.375
E61 Deficiency of other nutrient elements
0.000 0.627 0.373
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.628 0.372
E32 Diseases of thymus
0.000 0.628 0.372
E31 Polyglandular dysfunction
0.000 0.628 0.372
E30 Disorders of puberty, not elsewhere classified
0.000 0.628 0.372
E74 Other disorders of carbohydrate metabolism
0.000 0.630 0.370
D89.1 Cryoglobulinaemia
0.000 0.630 0.370
E85.9 Amyloidosis, unspecified
0.000 0.631 0.369
D69.5 Secondary thrombocytopenia
0.000 0.632 0.368
E34.0 Carcinoid syndrome
0.000 0.634 0.366
D69.6 Thrombocytopenia, unspecified
0.000 0.634 0.366
E04.0 Non-toxic diffuse goitre
0.002 0.635 0.363
E27.5 Adrenomedullary hyperfunction
0.000 0.637 0.362
E27.0 Other adrenocortical overactivity
0.000 0.637 0.362
D58.2 Other haemoglobinopathies
0.000 0.640 0.360
E73 Lactose intolerance
0.000 0.641 0.359
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.000 0.644 0.356
E44.1 Mild protein-energy malnutrition
0.000 0.644 0.355
E44.0 Moderate protein-energy malnutrition
0.000 0.644 0.355
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
0.000 0.644 0.355
D57.1 Sickle-cell anaemia without crisis
0.000 0.647 0.353
E56.9 Vitamin deficiency, unspecified
0.000 0.649 0.351
E56.8 Deficiency of other vitamins
0.000 0.649 0.351
E56.0 Deficiency of vitamin E
0.000 0.649 0.351
D58.8 Other specified hereditary haemolytic anaemias
0.000 0.650 0.349
D58.1 Hereditary elliptocytosis
0.000 0.650 0.349
E86 Volume depletion
0.000 0.651 0.349
E70.3 Albinism
0.000 0.653 0.346
E27.2 Addisonian crisis
0.000 0.654 0.346
E27.8 Other specified disorders of adrenal gland
0.000 0.654 0.346
E20.9 Hypoparathyroidism, unspecified
0.000 0.659 0.341
E22 Hyperfunction of pituitary gland
0.000 0.660 0.340
E04.9 Non-toxic goitre, unspecified
0.000 0.661 0.339
E88.2 Lipomatosis, not elsewhere classified
0.000 0.662 0.338
D52.8 Other folate deficiency anaemias
0.000 0.665 0.335
D52.1 Drug-induced folate deficiency anaemia
0.000 0.665 0.335
D52.0 Dietary folate deficiency anaemia
0.000 0.665 0.335
E79.9 Disorder of purine and pyrimidine metabolism, unspecified
0.000 0.666 0.334
E79.8 Other disorders of purine and pyrimidine metabolism
0.000 0.666 0.334
E79.1 Lesch-Nyhan syndrome
0.000 0.666 0.334
K90.9 Intestinal malabsorption, unspecified
0.000 0.669 0.331
D69.9 Haemorrhagic condition, unspecified
0.000 0.670 0.330
E70.9 Disorder of aromatic amino-acid metabolism, unspecified
0.000 0.670 0.330
E70.8 Other disorders of aromatic amino-acid metabolism
0.000 0.670 0.330
E70.2 Disorders of tyrosine metabolism
0.000 0.670 0.330
E70.1 Other hyperphenylalaninaemias
0.000 0.670 0.330
E70.0 Classical phenylketonuria
0.000 0.670 0.330
E53.8 Deficiency of other specified B group vitamins
0.000 0.674 0.326
E66 Obesity
0.000 0.674 0.326
D69.8 Other specified haemorrhagic conditions
0.000 0.676 0.324
E34.5 Androgen resistance syndrome
0.000 0.680 0.320
E34.4 Constitutional tall stature
0.000 0.680 0.320
E34.2 Ectopic hormone secretion, not elsewhere classified
0.000 0.680 0.320
E34.1 Other hypersecretion of intestinal hormones
0.000 0.680 0.320
E71.3 Disorders of fatty-acid metabolism
0.000 0.681 0.318
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified
0.000 0.681 0.318
E71.1 Other disorders of branched-chain amino-acid metabolism
0.000 0.681 0.318
E71.0 Maple-syrup-urine disease
0.000 0.681 0.318
E76.9 Disorder of glucosaminoglycan metabolism, unspecified
0.000 0.681 0.318
E76.8 Other disorders of glucosaminoglycan metabolism
0.000 0.681 0.318
E76.3 Mucopolysaccharidosis, unspecified
0.000 0.681 0.318
E76.2 Other mucopolysaccharidoses
0.000 0.681 0.318
E76.1 Mucopolysaccharidosis, type II
0.000 0.681 0.318
E76.0 Mucopolysaccharidosis, type I
0.000 0.681 0.318
E77.9 Disorder of glycoprotein metabolism, unspecified
0.000 0.681 0.318
E77.8 Other disorders of glycoprotein metabolism
0.000 0.681 0.318
E77.1 Defects in glycoprotein degradation
0.000 0.681 0.318
E77.0 Defects in posttranslational modification of lysosomal enzymes
0.000 0.681 0.318
E04.8 Other specified non-toxic goitre
0.003 0.683 0.315
D58.9 Hereditary haemolytic anaemia, unspecified
0.000 0.683 0.317
D89.0 Polyclonal hypergammaglobulinaemia
0.000 0.684 0.316
E29 Testicular dysfunction
0.000 0.686 0.313
E65 Localised adiposity
0.000 0.688 0.312
D69.3 Idiopathic thrombocytopenic purpura
0.000 0.691 0.309
E34.3 Short stature, not elsewhere classified
0.000 0.693 0.307
D58.0 Hereditary spherocytosis
0.000 0.694 0.306
D69.1 Qualitative platelet defects
0.000 0.694 0.306
E24 Cushing's syndrome
0.000 0.695 0.305
K90.3 Pancreatic steatorrhoea
0.000 0.698 0.302
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.698 0.302
K90.1 Tropical sprue
0.000 0.698 0.302
E56.1 Deficiency of vitamin K
0.000 0.698 0.301
E20.8 Other hypoparathyroidism
0.000 0.702 0.298
E20.1 Pseudohypoparathyroidism
0.000 0.702 0.298
E20.0 Idiopathic hypoparathyroidism
0.000 0.702 0.298
E84.8 Cystic fibrosis with other manifestations
0.000 0.702 0.297
E84.1 Cystic fibrosis with intestinal manifestations
0.000 0.702 0.297
E84.0 Cystic fibrosis with pulmonary manifestations
0.000 0.702 0.297
D89.2 Hypergammaglobulinaemia, unspecified
0.000 0.706 0.294
E72.9 Disorder of amino-acid metabolism, unspecified
0.000 0.708 0.292
E72.8 Other specified disorders of amino-acid metabolism
0.000 0.708 0.292
E72.5 Disorders of glycine metabolism
0.000 0.708 0.292
E72.4 Disorders of ornithine metabolism
0.000 0.708 0.292
E72.3 Disorders of lysine and hydroxylysine metabolism
0.000 0.708 0.292
E72.2 Disorders of urea cycle metabolism
0.000 0.708 0.292
E72.1 Disorders of sulphur-bearing amino-acid metabolism
0.000 0.708 0.292
K90.8 Other intestinal malabsorption
0.000 0.711 0.289
D73 Diseases of spleen
0.000 0.713 0.287
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.000 0.713 0.286
D69.4 Other primary thrombocytopenia
0.000 0.716 0.284
E67.8 Other specified hyperalimentation
0.000 0.721 0.279
E67.3 Hypervitaminosis D
0.000 0.721 0.279
E67.2 Megavitamin-B6 syndrome
0.000 0.721 0.279
E67.1 Hypercarotenaemia
0.000 0.721 0.279
E67.0 Hypervitaminosis A
0.000 0.721 0.279
E80 Disorders of porphyrin and bilirubin metabolism
0.000 0.721 0.279
E66.0 Obesity due to excess calories
0.000 0.722 0.278
E27.4 Other and unspecified adrenocortical insufficiency
0.000 0.722 0.278
D60-D64 Aplastic and other anaemias
0.000 0.723 0.277
E66.2 Extreme obesity with alveolar hypoventilation
0.000 0.724 0.276
E25.9 Adrenogenital disorder, unspecified
0.000 0.725 0.275
E25.8 Other adrenogenital disorders
0.000 0.725 0.275
E22.1 Hyperprolactinaemia
0.000 0.729 0.270
D56.9 Thalassaemia, unspecified
0.001 0.730 0.269
D56.8 Other thalassaemias
0.001 0.730 0.269
D56.4 Hereditary persistence of foetal haemoglobin [HPFH]
0.001 0.730 0.269
D56.2 Delta-beta thalassaemia
0.001 0.730 0.269
D56.0 Alpha thalassaemia
0.001 0.730 0.269
E84.9 Cystic fibrosis, unspecified
0.000 0.731 0.268
E61.9 Deficiency of nutrient element, unspecified
0.000 0.732 0.267
E61.8 Deficiency of other specified nutrient elements
0.000 0.732 0.267
E61.7 Deficiency of multiple nutrient elements
0.000 0.732 0.267
E61.6 Vanadium deficiency
0.000 0.732 0.267
E61.5 Molybdenum deficiency
0.000 0.732 0.267
E61.4 Chromium deficiency
0.000 0.732 0.267
E61.3 Manganese deficiency
0.000 0.732 0.267
E61.0 Copper deficiency
0.000 0.732 0.267
E30.9 Disorder of puberty, unspecified
0.000 0.733 0.267
E30.8 Other disorders of puberty
0.000 0.733 0.267
E30.1 Precocious puberty
0.000 0.733 0.267
E30.0 Delayed puberty
0.000 0.733 0.267
E31.9 Polyglandular dysfunction, unspecified
0.000 0.733 0.267
E31.8 Other polyglandular dysfunction
0.000 0.733 0.267
E31.1 Polyglandular hyperfunction
0.000 0.733 0.267
E31.0 Autoimmune polyglandular failure
0.000 0.733 0.267
E32.9 Disease of thymus, unspecified
0.000 0.733 0.267
E32.8 Other diseases of thymus
0.000 0.733 0.267
E32.1 Abscess of thymus
0.000 0.733 0.267
E32.0 Persistent hyperplasia of thymus
0.000 0.733 0.267
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.733 0.267
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.733 0.267
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.733 0.267
E74.9 Disorder of carbohydrate metabolism, unspecified
0.000 0.735 0.265
E74.8 Other specified disorders of carbohydrate metabolism
0.000 0.735 0.265
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
0.000 0.735 0.265
E74.2 Disorders of galactose metabolism
0.000 0.735 0.265
E74.1 Disorders of fructose metabolism
0.000 0.735 0.265
E74.0 Glycogen storage disease
0.000 0.735 0.265
E26 Hyperaldosteronism
0.000 0.735 0.264
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.000 0.739 0.261
E73.8 Other lactose intolerance
0.000 0.742 0.258
E73.1 Secondary lactase deficiency
0.000 0.742 0.258
E73.0 Congenital lactase deficiency
0.000 0.742 0.258
E75.6 Lipid storage disorder, unspecified
0.000 0.745 0.255
E75.4 Neuronal ceroid lipofuscinosis
0.000 0.745 0.255
E75.3 Sphingolipidosis, unspecified
0.000 0.745 0.255
E75.1 Other gangliosidosis
0.000 0.745 0.255
E75.0 GM2 gangliosidosis
0.000 0.745 0.255
E72.0 Disorders of amino-acid transport
0.000 0.745 0.255
E34.8 Other specified endocrine disorders
0.000 0.750 0.249
E22.0 Acromegaly and pituitary gigantism
0.000 0.754 0.246
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.756 0.244
E22.8 Other hyperfunction of pituitary gland
0.000 0.756 0.244
E27.9 Disorder of adrenal gland, unspecified
0.000 0.757 0.242

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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