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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs2535311
log Bayes Factor = 72.2065
Chromosome 6   position 31,052,684  (GRCh37) Explore rs2535311 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E03.9 Hypothyroidism, unspecified
1.000 0.000 0.000
K90.0 Coeliac disease
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
R31 Unspecified haematuria
1.000 0.000 0.000
L40.9 Psoriasis, unspecified
0.000 0.000 1.000
E10-E14 Diabetes mellitus
0.000 0.001 0.999
E10.1 With ketoacidosis
0.000 0.002 0.998
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.003 0.997
E16.2 Hypoglycaemia, unspecified
0.000 0.003 0.997
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.003 0.997
E10.9 Without complications
0.000 0.004 0.996
E16 Other disorders of pancreatic internal secretion
0.000 0.004 0.996
E10.3 With ophthalmic complications
0.000 0.006 0.994
L40 Psoriasis
0.000 0.009 0.991
L40.5 Arthropathic psoriasis
0.000 0.022 0.978
D86.9 Sarcoidosis, unspecified
0.000 0.024 0.976
D86 Sarcoidosis
0.000 0.025 0.975
E00-E07 Disorders of thyroid gland
0.063 0.026 0.911
D80-D89 Certain disorders involving the immune mechanism
0.000 0.044 0.956
L40.0 Psoriasis vulgaris
0.000 0.053 0.947
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.000 0.055 0.945
D70-D77 Other diseases of blood and blood-forming organs
0.000 0.061 0.939
D70 Agranulocytosis
0.000 0.066 0.934
E05 Thyrotoxicosis [hyperthyroidism]
0.011 0.080 0.909
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.086 0.914
D50-D53 Nutritional anaemias
0.000 0.089 0.911
E10.2 With renal complications
0.000 0.092 0.908
E11 Non-insulin-dependent diabetes mellitus
0.000 0.095 0.905
D86.1 Sarcoidosis of lymph nodes
0.000 0.104 0.896
D51 Vitamin B12 deficiency anaemia
0.000 0.109 0.891
E10.8 With unspecified complications
0.000 0.110 0.890
D51.0 Vitamin B12 deficiency anaemia due to intrinsic factor deficiency
0.000 0.147 0.853
E10.4 With neurological complications
0.000 0.149 0.851
E11.5 With peripheral circulatory complications
0.000 0.158 0.842
E10.5 With peripheral circulatory complications
0.000 0.162 0.838
D86.0 Sarcoidosis of lung
0.000 0.162 0.838
D72 Other disorders of white blood cells
0.000 0.182 0.818
E10.6 With other specified complications
0.000 0.190 0.810
E11.3 With ophthalmic complications
0.000 0.201 0.799
D51.9 Vitamin B12 deficiency anaemia, unspecified
0.000 0.202 0.798
E11.4 With neurological complications
0.000 0.211 0.789
E50-E64 Other nutritional deficiencies
0.000 0.218 0.782
D53 Other nutritional anaemias
0.000 0.225 0.775
D75 Other diseases of blood and blood-forming organs
0.000 0.230 0.770
D86.8 Sarcoidosis of other and combined sites
0.000 0.230 0.770
E03 Other hypothyroidism
0.449 0.231 0.321
D80 Immunodeficiency with predominantly antibody defects
0.000 0.233 0.767
L40.4 Guttate psoriasis
0.000 0.237 0.763
L40.1 Generalised pustular psoriasis
0.000 0.237 0.763
E10.0 With coma
0.000 0.241 0.759
D83 Common variable immunodeficiency
0.000 0.247 0.753
D86.3 Sarcoidosis of skin
0.000 0.249 0.751
D55-D59 Haemolytic anaemias
0.000 0.254 0.746
D86.2 Sarcoidosis of lung with sarcoidosis of lymph nodes
0.000 0.255 0.745
E11.8 With unspecified complications
0.000 0.265 0.735
D72.8 Other specified disorders of white blood cells
0.000 0.267 0.733
E55 Vitamin D deficiency
0.000 0.278 0.722
E14 Unspecified diabetes mellitus
0.000 0.280 0.720
E10.7 With multiple complications
0.000 0.283 0.717
E12 Malnutrition-related diabetes mellitus
0.000 0.284 0.716
E15 Nondiabetic hypoglycaemic coma
0.000 0.285 0.714
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.286 0.714
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.286 0.714
E16.4 Abnormal secretion of gastrin
0.000 0.286 0.714
E16.3 Increased secretion of glucagon
0.000 0.286 0.714
L40.3 Pustulosis palmaris et plantaris
0.000 0.290 0.710
L40.2 Acrodermatitis continua
0.000 0.290 0.710
E13 Other specified diabetes mellitus
0.000 0.292 0.708
E11.1 With ketoacidosis
0.000 0.296 0.704
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.045 0.302 0.653
E00 Congenital iodine-deficiency syndrome
0.045 0.302 0.653
D59 Acquired haemolytic anaemia
0.000 0.306 0.694
E06 Thyroiditis
0.032 0.307 0.661
E40-E46 Malnutrition
0.000 0.308 0.692
D81 Combined immunodeficiencies
0.000 0.315 0.685
D53.9 Nutritional anaemia, unspecified
0.000 0.322 0.678
E55.9 Vitamin D deficiency, unspecified
0.000 0.322 0.678
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.323 0.677
E16.1 Other hypoglycaemia
0.000 0.324 0.676
D74 Methaemoglobinaemia
0.000 0.327 0.673
D77 Other disorders of blood and blood-forming organs in diseases classified elsewhere
0.000 0.327 0.673
D71 Functional disorders of polymorphonuclear neutrophils
0.000 0.327 0.673
E02 Subclinical iodine-deficiency hypothyroidism
0.044 0.328 0.628
D75.9 Disease of blood and blood-forming organs, unspecified
0.000 0.335 0.665
E05.5 Thyroid crisis or storm
0.008 0.340 0.652
E05.4 Thyrotoxicosis factitia
0.008 0.340 0.652
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.008 0.340 0.652
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.008 0.340 0.652
E11.6 With other specified complications
0.000 0.341 0.659
E83.1 Disorders of iron metabolism
0.000 0.342 0.658
D82 Immunodeficiency associated with other major defects
0.000 0.345 0.655
E11.7 With multiple complications
0.000 0.351 0.649
D51.8 Other vitamin B12 deficiency anaemias
0.000 0.361 0.639
D51.3 Other dietary vitamin B12 deficiency anaemia
0.000 0.361 0.639
D51.2 Transcobalamin II deficiency
0.000 0.361 0.639
D51.1 Vitamin B12 deficiency anaemia due to selective vitamin B12 malabsorption with proteinuria
0.000 0.361 0.639
D80.1 Nonfamilial hypogammaglobulinaemia
0.000 0.365 0.635
D59.9 Acquired haemolytic anaemia, unspecified
0.000 0.375 0.625
D76 Certain diseases involving lymphoreticular tissue and reticulohistiocytic system
0.000 0.377 0.623
E70-E90 Metabolic disorders
0.000 0.381 0.619
E05.8 Other thyrotoxicosis
0.008 0.383 0.609
E83 Disorders of mineral metabolism
0.000 0.388 0.612
D83.9 Common variable immunodeficiency, unspecified
0.000 0.393 0.607
E14.3 With ophthalmic complications
0.000 0.397 0.603
D75.0 Familial erythrocytosis
0.000 0.398 0.602
D80.2 Selective deficiency of immunoglobulin A [IgA]
0.000 0.401 0.599
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions
0.000 0.405 0.595
D80.3 Selective deficiency of immunoglobulin G [IgG] subclasses
0.000 0.407 0.593
E20-E35 Disorders of other endocrine glands
0.000 0.408 0.592
E06.9 Thyroiditis, unspecified
0.013 0.412 0.575
E51 Thiamine deficiency
0.000 0.413 0.587
E14.8 With unspecified complications
0.000 0.413 0.587
D59.1 Other autoimmune haemolytic anaemias
0.000 0.413 0.587
D72.9 Disorder of white blood cells, unspecified
0.000 0.414 0.586
D72.0 Genetic anomalies of leukocytes
0.000 0.414 0.586
E27.1 Primary adrenocortical insufficiency
0.000 0.417 0.583
E27 Other disorders of adrenal gland
0.000 0.419 0.581
D72.1 Eosinophilia
0.000 0.421 0.579
D84 Other immunodeficiencies
0.000 0.424 0.575
E88 Other metabolic disorders
0.000 0.437 0.563
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.439 0.561
E63 Other nutritional deficiencies
0.000 0.439 0.561
E50 Vitamin A deficiency
0.000 0.439 0.561
E60 Dietary zinc deficiency
0.000 0.439 0.561
E59 Dietary selenium deficiency
0.000 0.439 0.561
E52 Niacin deficiency [pellagra]
0.000 0.439 0.561
D50 Iron deficiency anaemia
0.000 0.440 0.560
D53.8 Other specified nutritional anaemias
0.000 0.444 0.556
D53.2 Scorbutic anaemia
0.000 0.444 0.556
D53.1 Other megaloblastic anaemias, not elsewhere classified
0.000 0.444 0.556
D53.0 Protein deficiency anaemia
0.000 0.444 0.556
E53 Deficiency of other B group vitamins
0.000 0.445 0.555
E14.1 With ketoacidosis
0.000 0.445 0.555
E03.5 Myxoedema coma
0.322 0.448 0.230
E03.4 Atrophy of thyroid (acquired)
0.322 0.448 0.230
E03.3 Postinfectious hypothyroidism
0.322 0.448 0.230
D80.8 Other immunodeficiencies with predominantly antibody defects
0.000 0.450 0.550
D80.7 Transient hypogammaglobulinaemia of infancy
0.000 0.450 0.550
D80.6 Antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinaemia
0.000 0.450 0.550
D80.5 Immunodeficiency with increased immunoglobulin M [IgM]
0.000 0.450 0.550
D80.0 Hereditary hypogammaglobulinaemia
0.000 0.450 0.550
E14.6 With other specified complications
0.000 0.452 0.548
D75.2 Essential thrombocytosis
0.000 0.452 0.548
E03.0 Congenital hypothyroidism with diffuse goitre
0.320 0.457 0.224
E85 Amyloidosis
0.000 0.460 0.540
D83.8 Other common variable immunodeficiencies
0.000 0.460 0.540
D83.2 Common variable immunodeficiency with autoantibodies to B- or T-cells
0.000 0.460 0.540
D83.1 Common variable immunodeficiency with predominant immunoregulatory T-cell disorders
0.000 0.460 0.540
D83.0 Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function
0.000 0.460 0.540
E54 Ascorbic acid deficiency
0.000 0.462 0.537
D55 Anaemia due to enzyme disorders
0.000 0.465 0.535
E65-E68 Obesity and other hyperalimentation
0.000 0.466 0.534
E13.9 Without complications
0.000 0.466 0.534
E07 Other disorders of thyroid
0.079 0.468 0.453
D89 Other disorders involving the immune mechanism, not elsewhere classified
0.000 0.470 0.530
E03.1 Congenital hypothyroidism without goitre
0.285 0.470 0.246
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.336 0.473 0.191
L40.8 Other psoriasis
0.000 0.480 0.520
E55.0 Rickets, active
0.000 0.482 0.517
E14.7 With multiple complications
0.000 0.484 0.516
E14.2 Withrenal complications
0.000 0.484 0.516
E14.0 With coma
0.000 0.484 0.516
D75.1 Secondary polycythaemia
0.000 0.484 0.516
E58 Dietary calcium deficiency
0.000 0.485 0.514
E12.9 Without complications
0.000 0.486 0.514
E12.8 With unspecified complications
0.000 0.486 0.514
E12.7 With multiple complications
0.000 0.486 0.514
E12.6 With other specified complications
0.000 0.486 0.514
E12.5 With peripheral circulatory complications
0.000 0.486 0.514
E12.4 With neurological complications
0.000 0.486 0.514
E12.3 With ophthalmic complications
0.000 0.486 0.514
E12.2 With renal complications
0.000 0.486 0.514
E12.1 With ketoacidosis
0.000 0.486 0.514
E12.0 With coma
0.000 0.486 0.514
E88.0 Disorders of plasma-protein metabolism, not elsewhere classified
0.000 0.487 0.513
D80.9 Immunodeficiency with predominantly antibody defects, unspecified
0.000 0.488 0.512
E56 Other vitamin deficiencies
0.000 0.490 0.509
D57 Sickle-cell disorders
0.000 0.491 0.509
E34 Other endocrine disorders
0.000 0.491 0.509
E13.8 With unspecified complications
0.000 0.492 0.507
E13.7 With multiple complications
0.000 0.492 0.507
E13.6 With other specified complications
0.000 0.492 0.507
E13.5 With peripheral circulatory complications
0.000 0.492 0.507
E13.4 With neurological complications
0.000 0.492 0.507
E13.2 With renal complications
0.000 0.492 0.507
E13.1 With ketoacidosis
0.000 0.492 0.507
E13.0 With coma
0.000 0.492 0.507
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.008 0.498 0.495
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.033 0.499 0.468
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.033 0.499 0.468
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.033 0.499 0.468
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.033 0.499 0.468
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.033 0.499 0.468
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.033 0.499 0.468
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.033 0.499 0.468
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.033 0.499 0.468
D75.8 Other specified diseases of blood and blood-forming organs
0.000 0.501 0.499
D59.8 Other acquired haemolytic anaemias
0.000 0.502 0.498
D59.6 Haemoglobinuria due to haemolysis from other external causes
0.000 0.502 0.498
D59.5 Paroxysmal nocturnal haemoglobinuria [Marchiafava-Micheli]
0.000 0.502 0.498
D59.4 Other nonautoimmune haemolytic anaemias
0.000 0.502 0.498
D59.3 Haemolytic-uraemic syndrome
0.000 0.502 0.498
D59.2 Drug-induced nonautoimmune haemolytic anaemia
0.000 0.502 0.498
D59.0 Drug-induced autoimmune haemolytic anaemia
0.000 0.502 0.498
E06.4 Drug-induced thyroiditis
0.023 0.503 0.474
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.023 0.503 0.474
E06.0 Acute thyroiditis
0.023 0.503 0.474
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.504 0.496
E45 Retarded development following protein-energy malnutrition
0.000 0.504 0.496
E43 Unspecified severe protein-energy malnutrition
0.000 0.504 0.496
E42 Marasmic kwashiorkor
0.000 0.504 0.496
E41 Nutritional marasmus
0.000 0.504 0.496
E40 Kwashiorkor
0.000 0.504 0.496
E03.8 Other specified hypothyroidism
0.292 0.508 0.200
D81.9 Combined immunodeficiency, unspecified
0.000 0.508 0.491
D81.8 Other combined immunodeficiencies
0.000 0.508 0.491
D81.7 Major histocompatibility complex class II deficiency
0.000 0.508 0.491
D81.6 Major histocompatibility complex class I deficiency
0.000 0.508 0.491
D81.5 Purine nucleoside phosphorylase [PNP] deficiency
0.000 0.508 0.491
D81.4 Nezelof's syndrome
0.000 0.508 0.491
D81.3 Adenosine deaminase [ADA] deficiency
0.000 0.508 0.491
D81.2 Severe combined immunodeficiency [SCID] with low or normal B-cell numbers
0.000 0.508 0.491
D81.1 Severe combined immunodeficiency [SCID] with low T- and B-cell numbers
0.000 0.508 0.491
D81.0 Severe combined immunodeficiency [SCID] with reticular dysgenesis
0.000 0.508 0.491
E05.9 Thyrotoxicosis, unspecified
0.000 0.513 0.486
D74.9 Methaemoglobinaemia, unspecified
0.000 0.517 0.483
D74.8 Other methaemoglobinaemias
0.000 0.517 0.483
D74.0 Congenital methaemoglobinaemia
0.000 0.517 0.483
E85.4 Organ-limited amyloidosis
0.000 0.518 0.482
D66 Hereditary factor VIII deficiency
0.000 0.521 0.479
E11.2 With renal complications
0.000 0.521 0.479
E06.3 Autoimmune thyroiditis
0.011 0.523 0.466
E14.5 With peripheral circulatory complications
0.000 0.525 0.475
E46 Unspecified protein-energy malnutrition
0.000 0.527 0.473
E20 Hypoparathyroidism
0.000 0.527 0.473
E14.4 With neurological complications
0.000 0.527 0.472
D82.9 Immunodeficiency associated with major defect, unspecified
0.000 0.530 0.469
D82.8 Immunodeficiency associated with other specified major defects
0.000 0.530 0.469
D82.4 Hyperimmunoglobulin E [IgE] syndrome
0.000 0.530 0.469
D82.3 Immunodeficiency following hereditary defective response to Epstein-Barr virus
0.000 0.530 0.469
D82.2 Immunodeficiency with short-limbed stature
0.000 0.530 0.469
D82.0 Wiskott-Aldrich syndrome
0.000 0.530 0.469
D58 Other hereditary haemolytic anaemias
0.000 0.531 0.469
E13.3 With ophthalmic complications
0.000 0.533 0.466
E79 Disorders of purine and pyrimidine metabolism
0.000 0.534 0.465
D80.4 Selective deficiency of immunoglobulin M [IgM]
0.000 0.535 0.465
D52 Folate deficiency anaemia
0.000 0.539 0.461
E70 Disorders of aromatic amino-acid metabolism
0.000 0.540 0.460
D65 Disseminated intravascular coagulation [defibrination syndrome]
0.000 0.542 0.458
E34.9 Endocrine disorder, unspecified
0.000 0.544 0.456
E88.1 Lipodystrophy, not elsewhere classified
0.000 0.548 0.452
D84.1 Defects in the complement system
0.000 0.550 0.449
E51.2 Wernicke's encephalopathy
0.000 0.553 0.447
E04 Other non-toxic goitre
0.004 0.553 0.443
D76.2 Haemophagocytic syndrome, infection-associated
0.000 0.553 0.446
D76.1 Haemophagocytic lymphohistiocytosis
0.000 0.553 0.446
D76.0 Langerhans' cell histiocytosis, not elsewhere classified
0.000 0.553 0.446
D50.8 Other iron deficiency anaemias
0.000 0.555 0.445
E27.3 Drug-induced adrenocortical insufficiency
0.000 0.555 0.445
E77 Disorders of glycoprotein metabolism
0.000 0.556 0.444
E76 Disorders of glycosaminoglycan metabolism
0.000 0.556 0.444
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.000 0.556 0.444
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.000 0.556 0.444
E88.9 Metabolic disorder, unspecified
0.000 0.560 0.440
E83.8 Other disorders of mineral metabolism
0.000 0.561 0.439
E83.2 Disorders of zinc metabolism
0.000 0.561 0.439
E83.0 Disorders of copper metabolism
0.000 0.561 0.439
D82.1 Di George's syndrome
0.000 0.561 0.439
E25 Adrenogenital disorders
0.000 0.563 0.437
D50.9 Iron deficiency anaemia, unspecified
0.000 0.565 0.435
E06.1 Subacute thyroiditis
0.026 0.568 0.407
E53.9 Vitamin B deficiency, unspecified
0.000 0.575 0.425
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.576 0.424
E32 Diseases of thymus
0.000 0.576 0.424
E31 Polyglandular dysfunction
0.000 0.576 0.424
E30 Disorders of puberty, not elsewhere classified
0.000 0.576 0.424
D69 Purpura and other haemorrhagic conditions
0.000 0.577 0.423
D67 Hereditary factor IX deficiency
0.000 0.578 0.422
E51.9 Thiamine deficiency, unspecified
0.000 0.579 0.421
E51.8 Other manifestations of thiamine deficiency
0.000 0.579 0.421
E51.1 Beriberi
0.000 0.579 0.421
K90 Intestinal malabsorption
0.000 0.579 0.421
E83.9 Disorder of mineral metabolism, unspecified
0.000 0.580 0.420
E34.0 Carcinoid syndrome
0.000 0.583 0.417
E27.5 Adrenomedullary hyperfunction
0.000 0.583 0.417
E27.0 Other adrenocortical overactivity
0.000 0.583 0.417
E88.3 Tumour lysis syndrome
0.000 0.583 0.417
E84 Cystic fibrosis
0.000 0.585 0.415
D84.8 Other specified immunodeficiencies
0.000 0.587 0.413
D84.0 Lymphocyte function antigen-1 [LFA-1] defect
0.000 0.587 0.413
E06.5 Other chronic thyroiditis
0.026 0.588 0.385
E27.2 Addisonian crisis
0.000 0.591 0.409
E85.3 Secondary systemic amyloidosis
0.000 0.592 0.408
E72 Other disorders of amino-acid metabolism
0.000 0.593 0.407
E61 Deficiency of other nutrient elements
0.000 0.595 0.405
E50.9 Vitamin A deficiency, unspecified
0.000 0.598 0.402
E50.8 Other manifestations of vitamin A deficiency
0.000 0.598 0.402
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.598 0.402
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.598 0.402
E50.5 Vitamin A deficiency with night blindness
0.000 0.598 0.402
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.598 0.402
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.598 0.402
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.598 0.402
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.598 0.402
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.598 0.402
E63.9 Nutritional deficiency, unspecified
0.000 0.598 0.402
E63.8 Other specified nutritional deficiencies
0.000 0.598 0.402
E63.1 Imbalance of constituents of food intake
0.000 0.598 0.402
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.598 0.402
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.598 0.402
E64.8 Sequelae of other nutritional deficiencies
0.000 0.598 0.402
E64.3 Sequelae of rickets
0.000 0.598 0.402
E64.2 Sequelae of vitamin C deficiency
0.000 0.598 0.402
E64.1 Sequelae of vitamin A deficiency
0.000 0.598 0.402
E64.0 Sequelae of protein-energy malnutrition
0.000 0.598 0.402
D89.8 Other specified disorders involving the immune mechanism, not elsewhere classified
0.000 0.598 0.402
D50.1 Sideropenic dysphagia
0.000 0.598 0.402
E53.1 Pyridoxine deficiency
0.000 0.602 0.398
E53.0 Riboflavin deficiency
0.000 0.602 0.398
E11.0 With coma
0.000 0.602 0.398
E07.8 Other specified disorders of thyroid
0.042 0.604 0.355
D76.3 Other histiocytosis syndromes
0.000 0.604 0.396
E27.8 Other specified disorders of adrenal gland
0.000 0.608 0.392
D89.9 Disorder involving the immune mechanism, unspecified
0.000 0.608 0.392
E20.9 Hypoparathyroidism, unspecified
0.000 0.612 0.388
E85.8 Other amyloidosis
0.000 0.612 0.387
E85.2 Heredofamilial amyloidosis, unspecified
0.000 0.612 0.387
E85.1 Neuropathic heredofamilial amyloidosis
0.000 0.612 0.387
E85.0 Nonneuropathic heredofamilial amyloidosis
0.000 0.612 0.387
E22 Hyperfunction of pituitary gland
0.000 0.613 0.386
D55.9 Anaemia due to enzyme disorder, unspecified
0.000 0.616 0.384
D55.8 Other anaemias due to enzyme disorders
0.000 0.616 0.384
D55.3 Anaemia due to disorders of nucleotide metabolism
0.000 0.616 0.384
D55.2 Anaemia due to disorders of glycolytic enzymes
0.000 0.616 0.384
D55.1 Anaemia due to other disorders of glutathione metabolism
0.000 0.616 0.384
D55.0 Anaemia due to glucose-6-phosphate dehydrogenase [G6PD] deficiency
0.000 0.616 0.384
E67 Other hyperalimentation
0.000 0.617 0.383
E68 Sequelae of hyperalimentation
0.000 0.617 0.383
E07.1 Dyshormogenetic goitre
0.057 0.618 0.325
E07.0 Hypersecretion of calcitonin
0.057 0.618 0.325
E88.8 Other specified metabolic disorders
0.000 0.619 0.381
D89.3 Immune reconstitution syndrome
0.000 0.620 0.380
E74 Other disorders of carbohydrate metabolism
0.000 0.624 0.376
E85.9 Amyloidosis, unspecified
0.000 0.631 0.369
E04.0 Non-toxic diffuse goitre
0.002 0.632 0.366
E56.9 Vitamin deficiency, unspecified
0.000 0.634 0.365
E56.8 Deficiency of other vitamins
0.000 0.634 0.365
E56.0 Deficiency of vitamin E
0.000 0.634 0.365
D57.8 Other sickle-cell disorders
0.000 0.635 0.365
D57.3 Sickle-cell trait
0.000 0.635 0.365
D57.2 Double heterozygous sickling disorders
0.000 0.635 0.365
D57.0 Sickle-cell anaemia with crisis
0.000 0.635 0.365
E34.5 Androgen resistance syndrome
0.000 0.635 0.365
E34.4 Constitutional tall stature
0.000 0.635 0.365
E34.2 Ectopic hormone secretion, not elsewhere classified
0.000 0.635 0.365
E34.1 Other hypersecretion of intestinal hormones
0.000 0.635 0.365
D89.1 Cryoglobulinaemia
0.000 0.635 0.365
E53.8 Deficiency of other specified B group vitamins
0.000 0.640 0.360
E73 Lactose intolerance
0.000 0.641 0.359
D56 Thalassaemia
0.001 0.641 0.358
E44.1 Mild protein-energy malnutrition
0.000 0.644 0.356
E44.0 Moderate protein-energy malnutrition
0.000 0.644 0.356
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.000 0.644 0.356
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
0.000 0.644 0.355
D69.2 Other nonthrombocytopenic purpura
0.000 0.648 0.352
E34.3 Short stature, not elsewhere classified
0.000 0.650 0.350
E04.9 Non-toxic goitre, unspecified
0.000 0.652 0.348
E24 Cushing's syndrome
0.000 0.652 0.347
E29 Testicular dysfunction
0.000 0.653 0.347
E70.3 Albinism
0.000 0.653 0.346
D58.2 Other haemoglobinopathies
0.000 0.654 0.346
D69.5 Secondary thrombocytopenia
0.000 0.655 0.345
E88.2 Lipomatosis, not elsewhere classified
0.000 0.658 0.342
D57.1 Sickle-cell anaemia without crisis
0.000 0.660 0.339
E20.8 Other hypoparathyroidism
0.000 0.661 0.339
E20.1 Pseudohypoparathyroidism
0.000 0.661 0.339
E20.0 Idiopathic hypoparathyroidism
0.000 0.661 0.339
D69.6 Thrombocytopenia, unspecified
0.000 0.663 0.337
D58.8 Other specified hereditary haemolytic anaemias
0.000 0.664 0.336
D58.1 Hereditary elliptocytosis
0.000 0.664 0.336
E79.9 Disorder of purine and pyrimidine metabolism, unspecified
0.000 0.666 0.334
E79.8 Other disorders of purine and pyrimidine metabolism
0.000 0.666 0.334
E79.1 Lesch-Nyhan syndrome
0.000 0.666 0.334
K90.9 Intestinal malabsorption, unspecified
0.000 0.669 0.331
E27.4 Other and unspecified adrenocortical insufficiency
0.000 0.669 0.331
D52.8 Other folate deficiency anaemias
0.000 0.669 0.330
D52.1 Drug-induced folate deficiency anaemia
0.000 0.669 0.330
D52.0 Dietary folate deficiency anaemia
0.000 0.669 0.330
E70.9 Disorder of aromatic amino-acid metabolism, unspecified
0.000 0.670 0.330
E70.8 Other disorders of aromatic amino-acid metabolism
0.000 0.670 0.330
E70.2 Disorders of tyrosine metabolism
0.000 0.670 0.330
E70.1 Other hyperphenylalaninaemias
0.000 0.670 0.330
E70.0 Classical phenylketonuria
0.000 0.670 0.330
E86 Volume depletion
0.000 0.672 0.328
E66 Obesity
0.000 0.672 0.328
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.000 0.673 0.327
E04.8 Other specified non-toxic goitre
0.003 0.679 0.317
E71.3 Disorders of fatty-acid metabolism
0.000 0.682 0.318
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified
0.000 0.682 0.318
E71.1 Other disorders of branched-chain amino-acid metabolism
0.000 0.682 0.318
E71.0 Maple-syrup-urine disease
0.000 0.682 0.318
E76.9 Disorder of glucosaminoglycan metabolism, unspecified
0.000 0.682 0.318
E76.8 Other disorders of glucosaminoglycan metabolism
0.000 0.682 0.318
E76.3 Mucopolysaccharidosis, unspecified
0.000 0.682 0.318
E76.2 Other mucopolysaccharidoses
0.000 0.682 0.318
E76.1 Mucopolysaccharidosis, type II
0.000 0.682 0.318
E76.0 Mucopolysaccharidosis, type I
0.000 0.682 0.318
E77.9 Disorder of glycoprotein metabolism, unspecified
0.000 0.682 0.318
E77.8 Other disorders of glycoprotein metabolism
0.000 0.682 0.318
E77.1 Defects in glycoprotein degradation
0.000 0.682 0.318
E77.0 Defects in posttranslational modification of lysosomal enzymes
0.000 0.682 0.318
E56.1 Deficiency of vitamin K
0.000 0.686 0.314
E25.9 Adrenogenital disorder, unspecified
0.000 0.686 0.314
E25.8 Other adrenogenital disorders
0.000 0.686 0.314
D89.0 Polyclonal hypergammaglobulinaemia
0.000 0.688 0.311
D69.9 Haemorrhagic condition, unspecified
0.000 0.691 0.309
E22.1 Hyperprolactinaemia
0.000 0.693 0.307
D58.9 Hereditary haemolytic anaemia, unspecified
0.000 0.695 0.305
E30.9 Disorder of puberty, unspecified
0.000 0.696 0.304
E30.8 Other disorders of puberty
0.000 0.696 0.304
E30.1 Precocious puberty
0.000 0.696 0.304
E30.0 Delayed puberty
0.000 0.696 0.304
E31.9 Polyglandular dysfunction, unspecified
0.000 0.696 0.304
E31.8 Other polyglandular dysfunction
0.000 0.696 0.304
E31.1 Polyglandular hyperfunction
0.000 0.696 0.304
E31.0 Autoimmune polyglandular failure
0.000 0.696 0.304
E32.9 Disease of thymus, unspecified
0.000 0.696 0.304
E32.8 Other diseases of thymus
0.000 0.696 0.304
E32.1 Abscess of thymus
0.000 0.696 0.304
E32.0 Persistent hyperplasia of thymus
0.000 0.696 0.304
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.696 0.304
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.696 0.304
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.696 0.304
D69.8 Other specified haemorrhagic conditions
0.000 0.696 0.304
E26 Hyperaldosteronism
0.000 0.698 0.301
K90.3 Pancreatic steatorrhoea
0.000 0.698 0.302
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.698 0.302
K90.1 Tropical sprue
0.000 0.698 0.302
E84.8 Cystic fibrosis with other manifestations
0.000 0.702 0.297
E84.1 Cystic fibrosis with intestinal manifestations
0.000 0.702 0.297
E84.0 Cystic fibrosis with pulmonary manifestations
0.000 0.702 0.297
D69.3 Idiopathic thrombocytopenic purpura
0.000 0.704 0.296
D58.0 Hereditary spherocytosis
0.000 0.705 0.294
E72.9 Disorder of amino-acid metabolism, unspecified
0.000 0.708 0.292
E72.8 Other specified disorders of amino-acid metabolism
0.000 0.708 0.292
E72.5 Disorders of glycine metabolism
0.000 0.708 0.292
E72.4 Disorders of ornithine metabolism
0.000 0.708 0.292
E72.3 Disorders of lysine and hydroxylysine metabolism
0.000 0.708 0.292
E72.2 Disorders of urea cycle metabolism
0.000 0.708 0.292
E72.1 Disorders of sulphur-bearing amino-acid metabolism
0.000 0.708 0.292
E65 Localised adiposity
0.000 0.708 0.292
E61.9 Deficiency of nutrient element, unspecified
0.000 0.710 0.290
E61.8 Deficiency of other specified nutrient elements
0.000 0.710 0.290
E61.7 Deficiency of multiple nutrient elements
0.000 0.710 0.290
E61.6 Vanadium deficiency
0.000 0.710 0.290
E61.5 Molybdenum deficiency
0.000 0.710 0.290
E61.4 Chromium deficiency
0.000 0.710 0.290
E61.3 Manganese deficiency
0.000 0.710 0.290
E61.0 Copper deficiency
0.000 0.710 0.290
D89.2 Hypergammaglobulinaemia, unspecified
0.000 0.710 0.290
K90.8 Other intestinal malabsorption
0.000 0.711 0.289
D69.1 Qualitative platelet defects
0.000 0.713 0.287
E34.8 Other specified endocrine disorders
0.000 0.715 0.284
E27.9 Disorder of adrenal gland, unspecified
0.000 0.721 0.279
E66.2 Extreme obesity with alveolar hypoventilation
0.000 0.722 0.278
E66.0 Obesity due to excess calories
0.000 0.722 0.278
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.723 0.277
E22.8 Other hyperfunction of pituitary gland
0.000 0.723 0.277
E22.0 Acromegaly and pituitary gigantism
0.000 0.724 0.275
E67.8 Other specified hyperalimentation
0.000 0.725 0.275
E67.3 Hypervitaminosis D
0.000 0.725 0.275
E67.2 Megavitamin-B6 syndrome
0.000 0.725 0.275
E67.1 Hypercarotenaemia
0.000 0.725 0.275
E67.0 Hypervitaminosis A
0.000 0.725 0.275
E74.9 Disorder of carbohydrate metabolism, unspecified
0.000 0.730 0.270
E74.8 Other specified disorders of carbohydrate metabolism
0.000 0.730 0.270
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
0.000 0.730 0.270
E74.2 Disorders of galactose metabolism
0.000 0.730 0.270
E74.1 Disorders of fructose metabolism
0.000 0.730 0.270
E74.0 Glycogen storage disease
0.000 0.730 0.270
D60-D64 Aplastic and other anaemias
0.000 0.731 0.269
E80 Disorders of porphyrin and bilirubin metabolism
0.000 0.731 0.269
E24.0 Pituitary-dependent Cushing's disease
0.000 0.731 0.269
E84.9 Cystic fibrosis, unspecified
0.000 0.731 0.268
D69.4 Other primary thrombocytopenia
0.000 0.734 0.266
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.000 0.739 0.261
E73.8 Other lactose intolerance
0.000 0.742 0.258
E73.1 Secondary lactase deficiency
0.000 0.742 0.258
E73.0 Congenital lactase deficiency
0.000 0.742 0.258
D56.9 Thalassaemia, unspecified
0.001 0.743 0.257
D56.8 Other thalassaemias
0.001 0.743 0.257
D56.4 Hereditary persistence of foetal haemoglobin [HPFH]
0.001 0.743 0.257
D56.2 Delta-beta thalassaemia
0.001 0.743 0.257
D56.0 Alpha thalassaemia
0.001 0.743 0.257
E75.6 Lipid storage disorder, unspecified
0.000 0.745 0.255
E75.4 Neuronal ceroid lipofuscinosis
0.000 0.745 0.255
E75.3 Sphingolipidosis, unspecified
0.000 0.745 0.255
E75.1 Other gangliosidosis
0.000 0.745 0.255
E75.0 GM2 gangliosidosis
0.000 0.745 0.255
E72.0 Disorders of amino-acid transport
0.000 0.745 0.255

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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