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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs2535318
log Bayes Factor = 72.4951
Chromosome 6   position 31,051,388  (GRCh37) Explore rs2535318 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E03.9 Hypothyroidism, unspecified
1.000 0.000 0.000
K90.0 Coeliac disease
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
R31 Unspecified haematuria
1.000 0.000 0.000
E10-E14 Diabetes mellitus
0.000 0.000 1.000
L40.9 Psoriasis, unspecified
0.000 0.000 1.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.002 0.998
E10.1 With ketoacidosis
0.000 0.002 0.998
E16.2 Hypoglycaemia, unspecified
0.000 0.002 0.998
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.002 0.998
E16 Other disorders of pancreatic internal secretion
0.000 0.002 0.998
E10.9 Without complications
0.000 0.003 0.997
E10.3 With ophthalmic complications
0.000 0.005 0.995
L40 Psoriasis
0.000 0.013 0.987
D86.9 Sarcoidosis, unspecified
0.000 0.019 0.981
D86 Sarcoidosis
0.000 0.020 0.980
E00-E07 Disorders of thyroid gland
0.044 0.024 0.932
L40.5 Arthropathic psoriasis
0.000 0.029 0.971
D80-D89 Certain disorders involving the immune mechanism
0.000 0.033 0.967
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.000 0.041 0.959
D70-D77 Other diseases of blood and blood-forming organs
0.000 0.050 0.950
D70 Agranulocytosis
0.000 0.056 0.944
L40.0 Psoriasis vulgaris
0.000 0.060 0.940
E05 Thyrotoxicosis [hyperthyroidism]
0.007 0.063 0.930
E11 Non-insulin-dependent diabetes mellitus
0.000 0.066 0.934
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.067 0.933
D50-D53 Nutritional anaemias
0.000 0.077 0.923
E10.2 With renal complications
0.000 0.088 0.912
D86.1 Sarcoidosis of lymph nodes
0.000 0.097 0.903
D51 Vitamin B12 deficiency anaemia
0.000 0.105 0.895
E10.8 With unspecified complications
0.000 0.108 0.892
E10.4 With neurological complications
0.000 0.121 0.879
E50-E64 Other nutritional deficiencies
0.000 0.126 0.874
E11.5 With peripheral circulatory complications
0.000 0.128 0.872
E10.5 With peripheral circulatory complications
0.000 0.135 0.865
E11.3 With ophthalmic complications
0.000 0.144 0.856
D51.0 Vitamin B12 deficiency anaemia due to intrinsic factor deficiency
0.000 0.158 0.842
E55 Vitamin D deficiency
0.000 0.175 0.825
E11.4 With neurological complications
0.000 0.177 0.823
D86.0 Sarcoidosis of lung
0.000 0.179 0.821
E10.6 With other specified complications
0.000 0.186 0.814
D72 Other disorders of white blood cells
0.000 0.187 0.813
D80 Immunodeficiency with predominantly antibody defects
0.000 0.194 0.806
D51.9 Vitamin B12 deficiency anaemia, unspecified
0.000 0.203 0.797
E14 Unspecified diabetes mellitus
0.000 0.205 0.795
E55.9 Vitamin D deficiency, unspecified
0.000 0.209 0.791
D53 Other nutritional anaemias
0.000 0.211 0.789
D86.8 Sarcoidosis of other and combined sites
0.000 0.220 0.780
D55-D59 Haemolytic anaemias
0.000 0.224 0.775
D75 Other diseases of blood and blood-forming organs
0.000 0.230 0.770
E03 Other hypothyroidism
0.419 0.236 0.345
D83 Common variable immunodeficiency
0.000 0.236 0.763
E10.0 With coma
0.000 0.237 0.763
L40.4 Guttate psoriasis
0.000 0.239 0.761
D86.3 Sarcoidosis of skin
0.000 0.242 0.758
E11.8 With unspecified complications
0.000 0.244 0.756
E13 Other specified diabetes mellitus
0.000 0.247 0.753
D86.2 Sarcoidosis of lung with sarcoidosis of lymph nodes
0.000 0.250 0.750
L40.1 Generalised pustular psoriasis
0.000 0.265 0.735
D72.8 Other specified disorders of white blood cells
0.000 0.270 0.730
D59 Acquired haemolytic anaemia
0.000 0.271 0.729
E11.1 With ketoacidosis
0.000 0.279 0.721
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions
0.000 0.283 0.717
E10.7 With multiple complications
0.000 0.283 0.717
E12 Malnutrition-related diabetes mellitus
0.000 0.283 0.717
E15 Nondiabetic hypoglycaemic coma
0.000 0.285 0.715
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.285 0.715
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.285 0.715
E16.4 Abnormal secretion of gastrin
0.000 0.285 0.715
E16.3 Increased secretion of glucagon
0.000 0.285 0.715
L40.3 Pustulosis palmaris et plantaris
0.000 0.293 0.707
L40.2 Acrodermatitis continua
0.000 0.293 0.707
E14.3 With ophthalmic complications
0.000 0.297 0.703
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.032 0.300 0.668
E00 Congenital iodine-deficiency syndrome
0.032 0.300 0.668
D81 Combined immunodeficiencies
0.000 0.306 0.694
D53.9 Nutritional anaemia, unspecified
0.000 0.307 0.693
E11.6 With other specified complications
0.000 0.311 0.689
E40-E46 Malnutrition
0.000 0.314 0.686
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.317 0.683
E16.1 Other hypoglycaemia
0.000 0.319 0.681
D74 Methaemoglobinaemia
0.000 0.319 0.681
D77 Other disorders of blood and blood-forming organs in diseases classified elsewhere
0.000 0.319 0.681
D71 Functional disorders of polymorphonuclear neutrophils
0.000 0.319 0.681
E06 Thyroiditis
0.023 0.322 0.655
E02 Subclinical iodine-deficiency hypothyroidism
0.031 0.325 0.644
D80.1 Nonfamilial hypogammaglobulinaemia
0.000 0.328 0.672
E05.5 Thyroid crisis or storm
0.005 0.328 0.666
E05.4 Thyrotoxicosis factitia
0.005 0.328 0.666
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.005 0.328 0.666
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.005 0.328 0.666
D50 Iron deficiency anaemia
0.000 0.329 0.671
E11.7 With multiple complications
0.000 0.330 0.669
D82 Immunodeficiency associated with other major defects
0.000 0.336 0.664
E53 Deficiency of other B group vitamins
0.000 0.340 0.660
D59.9 Acquired haemolytic anaemia, unspecified
0.000 0.342 0.658
E51 Thiamine deficiency
0.000 0.343 0.657
D75.9 Disease of blood and blood-forming organs, unspecified
0.000 0.344 0.656
D51.8 Other vitamin B12 deficiency anaemias
0.000 0.358 0.642
D51.3 Other dietary vitamin B12 deficiency anaemia
0.000 0.358 0.642
D51.2 Transcobalamin II deficiency
0.000 0.358 0.642
D51.1 Vitamin B12 deficiency anaemia due to selective vitamin B12 malabsorption with proteinuria
0.000 0.358 0.642
D76 Certain diseases involving lymphoreticular tissue and reticulohistiocytic system
0.000 0.366 0.634
D80.2 Selective deficiency of immunoglobulin A [IgA]
0.000 0.369 0.631
E05.8 Other thyrotoxicosis
0.005 0.369 0.626
D59.1 Other autoimmune haemolytic anaemias
0.000 0.369 0.631
E14.8 With unspecified complications
0.000 0.370 0.630
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.373 0.626
E63 Other nutritional deficiencies
0.000 0.373 0.626
E50 Vitamin A deficiency
0.000 0.373 0.626
E60 Dietary zinc deficiency
0.000 0.373 0.626
E59 Dietary selenium deficiency
0.000 0.373 0.626
E52 Niacin deficiency [pellagra]
0.000 0.373 0.626
D80.3 Selective deficiency of immunoglobulin G [IgG] subclasses
0.000 0.376 0.624
D83.9 Common variable immunodeficiency, unspecified
0.000 0.383 0.617
E14.1 With ketoacidosis
0.000 0.385 0.615
E58 Dietary calcium deficiency
0.000 0.389 0.611
D75.0 Familial erythrocytosis
0.000 0.396 0.604
E54 Ascorbic acid deficiency
0.000 0.399 0.601
D69 Purpura and other haemorrhagic conditions
0.000 0.408 0.592
E55.0 Rickets, active
0.000 0.408 0.592
D84 Other immunodeficiencies
0.000 0.414 0.585
E13.9 Without complications
0.000 0.415 0.585
E14.6 With other specified complications
0.000 0.415 0.585
D72.9 Disorder of white blood cells, unspecified
0.000 0.417 0.583
D72.0 Genetic anomalies of leukocytes
0.000 0.417 0.583
D66 Hereditary factor VIII deficiency
0.000 0.418 0.582
D80.8 Other immunodeficiencies with predominantly antibody defects
0.000 0.422 0.578
D80.7 Transient hypogammaglobulinaemia of infancy
0.000 0.422 0.578
D80.6 Antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinaemia
0.000 0.422 0.578
D80.5 Immunodeficiency with increased immunoglobulin M [IgM]
0.000 0.422 0.578
D80.0 Hereditary hypogammaglobulinaemia
0.000 0.422 0.578
D80.9 Immunodeficiency with predominantly antibody defects, unspecified
0.000 0.429 0.571
E06.9 Thyroiditis, unspecified
0.010 0.430 0.561
E14.7 With multiple complications
0.000 0.430 0.570
E14.2 Withrenal complications
0.000 0.430 0.570
E14.0 With coma
0.000 0.430 0.570
E56 Other vitamin deficiencies
0.000 0.430 0.570
D53.8 Other specified nutritional anaemias
0.000 0.434 0.566
D53.2 Scorbutic anaemia
0.000 0.434 0.566
D53.1 Other megaloblastic anaemias, not elsewhere classified
0.000 0.434 0.566
D53.0 Protein deficiency anaemia
0.000 0.434 0.566
D50.9 Iron deficiency anaemia, unspecified
0.000 0.438 0.562
E14.5 With peripheral circulatory complications
0.000 0.442 0.558
E65-E68 Obesity and other hyperalimentation
0.000 0.443 0.557
D55 Anaemia due to enzyme disorders
0.000 0.444 0.556
D75.2 Essential thrombocytosis
0.000 0.444 0.556
D50.8 Other iron deficiency anaemias
0.000 0.444 0.556
D65 Disseminated intravascular coagulation [defibrination syndrome]
0.000 0.445 0.555
D89 Other disorders involving the immune mechanism, not elsewhere classified
0.000 0.450 0.550
E03.5 Myxoedema coma
0.301 0.452 0.247
E03.4 Atrophy of thyroid (acquired)
0.301 0.452 0.247
E03.3 Postinfectious hypothyroidism
0.301 0.452 0.247
D83.8 Other common variable immunodeficiencies
0.000 0.452 0.547
D83.2 Common variable immunodeficiency with autoantibodies to B- or T-cells
0.000 0.452 0.547
D83.1 Common variable immunodeficiency with predominant immunoregulatory T-cell disorders
0.000 0.452 0.547
D83.0 Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function
0.000 0.452 0.547
D72.1 Eosinophilia
0.000 0.457 0.543
E07 Other disorders of thyroid
0.056 0.457 0.487
E13.8 With unspecified complications
0.000 0.460 0.540
E13.7 With multiple complications
0.000 0.460 0.540
E13.6 With other specified complications
0.000 0.460 0.540
E13.5 With peripheral circulatory complications
0.000 0.460 0.540
E13.4 With neurological complications
0.000 0.460 0.540
E13.2 With renal complications
0.000 0.460 0.540
E13.1 With ketoacidosis
0.000 0.460 0.540
E13.0 With coma
0.000 0.460 0.540
E03.0 Congenital hypothyroidism with diffuse goitre
0.298 0.461 0.241
E03.1 Congenital hypothyroidism without goitre
0.266 0.470 0.265
D57 Sickle-cell disorders
0.000 0.470 0.530
E13.3 With ophthalmic complications
0.000 0.473 0.527
E14.4 With neurological complications
0.000 0.476 0.524
D67 Hereditary factor IX deficiency
0.000 0.476 0.524
D59.8 Other acquired haemolytic anaemias
0.000 0.477 0.522
D59.6 Haemoglobinuria due to haemolysis from other external causes
0.000 0.477 0.522
D59.5 Paroxysmal nocturnal haemoglobinuria [Marchiafava-Micheli]
0.000 0.477 0.522
D59.4 Other nonautoimmune haemolytic anaemias
0.000 0.477 0.522
D59.3 Haemolytic-uraemic syndrome
0.000 0.477 0.522
D59.2 Drug-induced nonautoimmune haemolytic anaemia
0.000 0.477 0.522
D59.0 Drug-induced autoimmune haemolytic anaemia
0.000 0.477 0.522
L40.8 Other psoriasis
0.000 0.478 0.522
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.005 0.479 0.515
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.312 0.481 0.207
E12.9 Without complications
0.000 0.486 0.514
E12.8 With unspecified complications
0.000 0.486 0.514
E12.7 With multiple complications
0.000 0.486 0.514
E12.6 With other specified complications
0.000 0.486 0.514
E12.5 With peripheral circulatory complications
0.000 0.486 0.514
E12.4 With neurological complications
0.000 0.486 0.514
E12.3 With ophthalmic complications
0.000 0.486 0.514
E12.2 With renal complications
0.000 0.486 0.514
E12.1 With ketoacidosis
0.000 0.486 0.514
E12.0 With coma
0.000 0.486 0.514
D75.8 Other specified diseases of blood and blood-forming organs
0.000 0.487 0.513
E53.9 Vitamin B deficiency, unspecified
0.000 0.493 0.507
E51.2 Wernicke's encephalopathy
0.000 0.498 0.502
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.023 0.498 0.479
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.023 0.498 0.479
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.023 0.498 0.479
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.023 0.498 0.479
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.023 0.498 0.479
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.023 0.498 0.479
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.023 0.498 0.479
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.023 0.498 0.479
E05.9 Thyrotoxicosis, unspecified
0.000 0.499 0.501
E20-E35 Disorders of other endocrine glands
0.000 0.502 0.498
D81.9 Combined immunodeficiency, unspecified
0.000 0.503 0.497
D81.8 Other combined immunodeficiencies
0.000 0.503 0.497
D81.7 Major histocompatibility complex class II deficiency
0.000 0.503 0.497
D81.6 Major histocompatibility complex class I deficiency
0.000 0.503 0.497
D81.5 Purine nucleoside phosphorylase [PNP] deficiency
0.000 0.503 0.497
D81.4 Nezelof's syndrome
0.000 0.503 0.497
D81.3 Adenosine deaminase [ADA] deficiency
0.000 0.503 0.497
D81.2 Severe combined immunodeficiency [SCID] with low or normal B-cell numbers
0.000 0.503 0.497
D81.1 Severe combined immunodeficiency [SCID] with low T- and B-cell numbers
0.000 0.503 0.497
D81.0 Severe combined immunodeficiency [SCID] with reticular dysgenesis
0.000 0.503 0.497
D75.1 Secondary polycythaemia
0.000 0.506 0.494
D69.2 Other nonthrombocytopenic purpura
0.000 0.506 0.494
D58 Other hereditary haemolytic anaemias
0.000 0.507 0.493
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.508 0.492
E45 Retarded development following protein-energy malnutrition
0.000 0.508 0.492
E43 Unspecified severe protein-energy malnutrition
0.000 0.508 0.492
E42 Marasmic kwashiorkor
0.000 0.508 0.492
E41 Nutritional marasmus
0.000 0.508 0.492
E40 Kwashiorkor
0.000 0.508 0.492
E27.1 Primary adrenocortical insufficiency
0.000 0.509 0.491
D80.4 Selective deficiency of immunoglobulin M [IgM]
0.000 0.510 0.489
E27 Other disorders of adrenal gland
0.000 0.511 0.489
D74.9 Methaemoglobinaemia, unspecified
0.000 0.512 0.488
D74.8 Other methaemoglobinaemias
0.000 0.512 0.488
D74.0 Congenital methaemoglobinaemia
0.000 0.512 0.488
D69.6 Thrombocytopenia, unspecified
0.000 0.512 0.488
E03.8 Other specified hypothyroidism
0.270 0.512 0.218
D69.5 Secondary thrombocytopenia
0.000 0.513 0.486
E06.4 Drug-induced thyroiditis
0.016 0.514 0.469
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.016 0.514 0.469
E06.0 Acute thyroiditis
0.016 0.514 0.469
D50.1 Sideropenic dysphagia
0.000 0.519 0.481
D82.9 Immunodeficiency associated with major defect, unspecified
0.000 0.524 0.476
D82.8 Immunodeficiency associated with other specified major defects
0.000 0.524 0.476
D82.4 Hyperimmunoglobulin E [IgE] syndrome
0.000 0.524 0.476
D82.3 Immunodeficiency following hereditary defective response to Epstein-Barr virus
0.000 0.524 0.476
D82.2 Immunodeficiency with short-limbed stature
0.000 0.524 0.476
D82.0 Wiskott-Aldrich syndrome
0.000 0.524 0.476
D69.3 Idiopathic thrombocytopenic purpura
0.000 0.526 0.474
E53.1 Pyridoxine deficiency
0.000 0.526 0.473
E53.0 Riboflavin deficiency
0.000 0.526 0.473
E53.8 Deficiency of other specified B group vitamins
0.000 0.527 0.473
E51.9 Thiamine deficiency, unspecified
0.000 0.529 0.471
E51.8 Other manifestations of thiamine deficiency
0.000 0.529 0.471
E51.1 Beriberi
0.000 0.529 0.471
E06.3 Autoimmune thyroiditis
0.008 0.533 0.459
E04 Other non-toxic goitre
0.003 0.534 0.463
E83.1 Disorders of iron metabolism
0.000 0.536 0.464
E46 Unspecified protein-energy malnutrition
0.000 0.538 0.462
D84.1 Defects in the complement system
0.000 0.542 0.458
E11.2 With renal complications
0.000 0.544 0.456
E61 Deficiency of other nutrient elements
0.000 0.544 0.455
D76.2 Haemophagocytic syndrome, infection-associated
0.000 0.545 0.455
D76.1 Haemophagocytic lymphohistiocytosis
0.000 0.545 0.455
D76.0 Langerhans' cell histiocytosis, not elsewhere classified
0.000 0.545 0.455
K90 Intestinal malabsorption
0.000 0.550 0.450
E50.9 Vitamin A deficiency, unspecified
0.000 0.551 0.449
E50.8 Other manifestations of vitamin A deficiency
0.000 0.551 0.449
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.551 0.449
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.551 0.449
E50.5 Vitamin A deficiency with night blindness
0.000 0.551 0.449
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.551 0.449
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.551 0.449
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.551 0.449
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.551 0.449
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.551 0.449
E63.9 Nutritional deficiency, unspecified
0.000 0.551 0.449
E63.8 Other specified nutritional deficiencies
0.000 0.551 0.449
E63.1 Imbalance of constituents of food intake
0.000 0.551 0.449
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.551 0.449
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.551 0.449
E64.8 Sequelae of other nutritional deficiencies
0.000 0.551 0.449
E64.3 Sequelae of rickets
0.000 0.551 0.449
E64.2 Sequelae of vitamin C deficiency
0.000 0.551 0.449
E64.1 Sequelae of vitamin A deficiency
0.000 0.551 0.449
E64.0 Sequelae of protein-energy malnutrition
0.000 0.551 0.449
D52 Folate deficiency anaemia
0.001 0.551 0.449
D82.1 Di George's syndrome
0.000 0.554 0.446
E70-E90 Metabolic disorders
0.000 0.560 0.440
D69.9 Haemorrhagic condition, unspecified
0.000 0.564 0.436
E83 Disorders of mineral metabolism
0.000 0.570 0.430
E34 Other endocrine disorders
0.000 0.574 0.426
D69.8 Other specified haemorrhagic conditions
0.000 0.575 0.424
E06.1 Subacute thyroiditis
0.018 0.578 0.404
D84.8 Other specified immunodeficiencies
0.000 0.580 0.420
D84.0 Lymphocyte function antigen-1 [LFA-1] defect
0.000 0.580 0.420
E07.8 Other specified disorders of thyroid
0.028 0.580 0.392
E11.0 With coma
0.000 0.581 0.418
D89.8 Other specified disorders involving the immune mechanism, not elsewhere classified
0.000 0.582 0.418
E56.9 Vitamin deficiency, unspecified
0.000 0.591 0.409
E56.8 Deficiency of other vitamins
0.000 0.591 0.409
E56.0 Deficiency of vitamin E
0.000 0.591 0.409
D89.9 Disorder involving the immune mechanism, unspecified
0.000 0.592 0.408
D76.3 Other histiocytosis syndromes
0.000 0.592 0.407
D69.1 Qualitative platelet defects
0.000 0.598 0.401
E06.5 Other chronic thyroiditis
0.019 0.599 0.383
E67 Other hyperalimentation
0.000 0.600 0.400
E68 Sequelae of hyperalimentation
0.000 0.600 0.400
D55.9 Anaemia due to enzyme disorder, unspecified
0.000 0.601 0.399
D55.8 Other anaemias due to enzyme disorders
0.000 0.601 0.399
D55.3 Anaemia due to disorders of nucleotide metabolism
0.000 0.601 0.399
D55.2 Anaemia due to disorders of glycolytic enzymes
0.000 0.601 0.399
D55.1 Anaemia due to other disorders of glutathione metabolism
0.000 0.601 0.399
D55.0 Anaemia due to glucose-6-phosphate dehydrogenase [G6PD] deficiency
0.000 0.601 0.399
E88 Other metabolic disorders
0.000 0.602 0.398
D89.3 Immune reconstitution syndrome
0.000 0.606 0.394
E20 Hypoparathyroidism
0.000 0.610 0.390
E07.1 Dyshormogenetic goitre
0.040 0.610 0.349
E07.0 Hypersecretion of calcitonin
0.040 0.610 0.349
E85 Amyloidosis
0.000 0.612 0.388
E04.0 Non-toxic diffuse goitre
0.001 0.614 0.385
D57.8 Other sickle-cell disorders
0.000 0.620 0.380
D57.3 Sickle-cell trait
0.000 0.620 0.380
D57.2 Double heterozygous sickling disorders
0.000 0.620 0.380
D57.0 Sickle-cell anaemia with crisis
0.000 0.620 0.380
D89.1 Cryoglobulinaemia
0.000 0.621 0.379
E34.9 Endocrine disorder, unspecified
0.000 0.624 0.376
E27.3 Drug-induced adrenocortical insufficiency
0.000 0.625 0.375
D69.4 Other primary thrombocytopenia
0.000 0.626 0.374
E66 Obesity
0.000 0.628 0.372
E25 Adrenogenital disorders
0.000 0.631 0.369
D58.2 Other haemoglobinopathies
0.000 0.635 0.365
E88.0 Disorders of plasma-protein metabolism, not elsewhere classified
0.000 0.637 0.362
K90.9 Intestinal malabsorption, unspecified
0.000 0.638 0.362
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.643 0.357
E32 Diseases of thymus
0.000 0.643 0.357
E31 Polyglandular dysfunction
0.000 0.643 0.357
E30 Disorders of puberty, not elsewhere classified
0.000 0.643 0.357
E04.9 Non-toxic goitre, unspecified
0.000 0.646 0.354
D57.1 Sickle-cell anaemia without crisis
0.000 0.646 0.353
D58.8 Other specified hereditary haemolytic anaemias
0.000 0.646 0.353
D58.1 Hereditary elliptocytosis
0.000 0.646 0.353
E44.1 Mild protein-energy malnutrition
0.000 0.647 0.353
E44.0 Moderate protein-energy malnutrition
0.000 0.647 0.353
E56.1 Deficiency of vitamin K
0.000 0.647 0.352
D56 Thalassaemia
0.001 0.649 0.350
E27.5 Adrenomedullary hyperfunction
0.000 0.649 0.350
E27.0 Other adrenocortical overactivity
0.000 0.649 0.350
E85.4 Organ-limited amyloidosis
0.000 0.652 0.348
E27.2 Addisonian crisis
0.000 0.654 0.346
E34.0 Carcinoid syndrome
0.000 0.656 0.344
E04.8 Other specified non-toxic goitre
0.002 0.666 0.332
E79 Disorders of purine and pyrimidine metabolism
0.000 0.668 0.332
E70 Disorders of aromatic amino-acid metabolism
0.000 0.672 0.328
E61.9 Deficiency of nutrient element, unspecified
0.000 0.673 0.327
E61.8 Deficiency of other specified nutrient elements
0.000 0.673 0.327
E61.7 Deficiency of multiple nutrient elements
0.000 0.673 0.327
E61.6 Vanadium deficiency
0.000 0.673 0.327
E61.5 Molybdenum deficiency
0.000 0.673 0.327
E61.4 Chromium deficiency
0.000 0.673 0.327
E61.3 Manganese deficiency
0.000 0.673 0.327
E61.0 Copper deficiency
0.000 0.673 0.327
D89.0 Polyclonal hypergammaglobulinaemia
0.000 0.676 0.324
K90.3 Pancreatic steatorrhoea
0.000 0.677 0.323
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.677 0.323
K90.1 Tropical sprue
0.000 0.677 0.323
D58.9 Hereditary haemolytic anaemia, unspecified
0.000 0.677 0.323
D52.8 Other folate deficiency anaemias
0.001 0.678 0.322
D52.1 Drug-induced folate deficiency anaemia
0.001 0.678 0.322
D52.0 Dietary folate deficiency anaemia
0.001 0.678 0.322
E88.1 Lipodystrophy, not elsewhere classified
0.000 0.680 0.320
E27.8 Other specified disorders of adrenal gland
0.000 0.680 0.320
E66.2 Extreme obesity with alveolar hypoventilation
0.000 0.683 0.317
E77 Disorders of glycoprotein metabolism
0.000 0.684 0.316
E76 Disorders of glycosaminoglycan metabolism
0.000 0.684 0.316
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.000 0.684 0.316
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.000 0.684 0.316
E20.9 Hypoparathyroidism, unspecified
0.000 0.687 0.313
D58.0 Hereditary spherocytosis
0.000 0.688 0.312
E88.9 Metabolic disorder, unspecified
0.000 0.688 0.312
K90.8 Other intestinal malabsorption
0.000 0.689 0.311
E66.0 Obesity due to excess calories
0.000 0.691 0.309
E83.8 Other disorders of mineral metabolism
0.000 0.691 0.308
E83.2 Disorders of zinc metabolism
0.000 0.691 0.308
E83.0 Disorders of copper metabolism
0.000 0.691 0.308
D89.2 Hypergammaglobulinaemia, unspecified
0.000 0.693 0.307
D60-D64 Aplastic and other anaemias
0.000 0.693 0.307
E34.5 Androgen resistance syndrome
0.000 0.695 0.305
E34.4 Constitutional tall stature
0.000 0.695 0.305
E34.2 Ectopic hormone secretion, not elsewhere classified
0.000 0.695 0.305
E34.1 Other hypersecretion of intestinal hormones
0.000 0.695 0.305
E22 Hyperfunction of pituitary gland
0.000 0.700 0.300
E24 Cushing's syndrome
0.000 0.702 0.298
E83.9 Disorder of mineral metabolism, unspecified
0.000 0.704 0.296
E84 Cystic fibrosis
0.000 0.704 0.295
E85.3 Secondary systemic amyloidosis
0.000 0.706 0.294
E34.3 Short stature, not elsewhere classified
0.000 0.707 0.293
E72 Other disorders of amino-acid metabolism
0.000 0.710 0.290
E65 Localised adiposity
0.000 0.712 0.288
E27.4 Other and unspecified adrenocortical insufficiency
0.000 0.712 0.288
E61.2 Magnesium deficiency
0.000 0.713 0.287
E67.8 Other specified hyperalimentation
0.000 0.713 0.287
E67.3 Hypervitaminosis D
0.000 0.713 0.287
E67.2 Megavitamin-B6 syndrome
0.000 0.713 0.287
E67.1 Hypercarotenaemia
0.000 0.713 0.287
E67.0 Hypervitaminosis A
0.000 0.713 0.287
E88.3 Tumour lysis syndrome
0.000 0.716 0.284
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.000 0.716 0.284
E29 Testicular dysfunction
0.000 0.716 0.283
E14.9 Without complications
0.000 0.720 0.280
E20.8 Other hypoparathyroidism
0.000 0.720 0.280
E20.1 Pseudohypoparathyroidism
0.000 0.720 0.280
E20.0 Idiopathic hypoparathyroidism
0.000 0.720 0.280
E85.8 Other amyloidosis
0.000 0.722 0.278
E85.2 Heredofamilial amyloidosis, unspecified
0.000 0.722 0.278
E85.1 Neuropathic heredofamilial amyloidosis
0.000 0.722 0.278
E85.0 Nonneuropathic heredofamilial amyloidosis
0.000 0.722 0.278
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.000 0.724 0.276
E88.8 Other specified metabolic disorders
0.000 0.730 0.270
E74 Other disorders of carbohydrate metabolism
0.000 0.731 0.269
E85.9 Amyloidosis, unspecified
0.000 0.732 0.268
E66.1 Drug-induced obesity
0.000 0.733 0.267
E25.9 Adrenogenital disorder, unspecified
0.000 0.735 0.264
E25.8 Other adrenogenital disorders
0.000 0.735 0.264
E34.8 Other specified endocrine disorders
0.000 0.743 0.257
E30.9 Disorder of puberty, unspecified
0.000 0.744 0.256
E30.8 Other disorders of puberty
0.000 0.744 0.256
E30.1 Precocious puberty
0.000 0.744 0.256
E30.0 Delayed puberty
0.000 0.744 0.256
E31.9 Polyglandular dysfunction, unspecified
0.000 0.744 0.256
E31.8 Other polyglandular dysfunction
0.000 0.744 0.256
E31.1 Polyglandular hyperfunction
0.000 0.744 0.256
E31.0 Autoimmune polyglandular failure
0.000 0.744 0.256
E32.9 Disease of thymus, unspecified
0.000 0.744 0.256
E32.8 Other diseases of thymus
0.000 0.744 0.256
E32.1 Abscess of thymus
0.000 0.744 0.256
E32.0 Persistent hyperplasia of thymus
0.000 0.744 0.256
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.744 0.256
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.744 0.256
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.744 0.256
D73 Diseases of spleen
0.000 0.744 0.256
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
0.000 0.746 0.254
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.000 0.746 0.254
D56.9 Thalassaemia, unspecified
0.001 0.748 0.251
D56.8 Other thalassaemias
0.001 0.748 0.251
D56.4 Hereditary persistence of foetal haemoglobin [HPFH]
0.001 0.748 0.251
D56.2 Delta-beta thalassaemia
0.001 0.748 0.251
D56.0 Alpha thalassaemia
0.001 0.748 0.251
E66.8 Other obesity
0.000 0.751 0.249
E26 Hyperaldosteronism
0.000 0.751 0.248
E70.3 Albinism
0.000 0.753 0.247
E73 Lactose intolerance
0.000 0.753 0.246
E88.2 Lipomatosis, not elsewhere classified
0.000 0.757 0.243
E22.1 Hyperprolactinaemia
0.000 0.759 0.240
E79.9 Disorder of purine and pyrimidine metabolism, unspecified
0.000 0.762 0.238
E79.8 Other disorders of purine and pyrimidine metabolism
0.000 0.762 0.238
E79.1 Lesch-Nyhan syndrome
0.000 0.762 0.238
E70.9 Disorder of aromatic amino-acid metabolism, unspecified
0.000 0.765 0.235
E70.8 Other disorders of aromatic amino-acid metabolism
0.000 0.765 0.235
E70.2 Disorders of tyrosine metabolism
0.000 0.765 0.235
E70.1 Other hyperphenylalaninaemias
0.000 0.765 0.235
E70.0 Classical phenylketonuria
0.000 0.765 0.235
E24.0 Pituitary-dependent Cushing's disease
0.000 0.769 0.231
D84.9 Immunodeficiency, unspecified
0.001 0.769 0.230
E71.3 Disorders of fatty-acid metabolism
0.000 0.773 0.226
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified
0.000 0.773 0.226
E71.1 Other disorders of branched-chain amino-acid metabolism
0.000 0.773 0.226
E71.0 Maple-syrup-urine disease
0.000 0.773 0.226
E76.9 Disorder of glucosaminoglycan metabolism, unspecified
0.000 0.773 0.226
E76.8 Other disorders of glucosaminoglycan metabolism
0.000 0.773 0.226
E76.3 Mucopolysaccharidosis, unspecified
0.000 0.773 0.226
E76.2 Other mucopolysaccharidoses
0.000 0.773 0.226
E76.1 Mucopolysaccharidosis, type II
0.000 0.773 0.226
E76.0 Mucopolysaccharidosis, type I
0.000 0.773 0.226
E77.9 Disorder of glycoprotein metabolism, unspecified
0.000 0.773 0.226
E77.8 Other disorders of glycoprotein metabolism
0.000 0.773 0.226
E77.1 Defects in glycoprotein degradation
0.000 0.773 0.226
E77.0 Defects in posttranslational modification of lysosomal enzymes
0.000 0.773 0.226
E61.1 Iron deficiency
0.000 0.774 0.226
D61 Other aplastic anaemias
0.000 0.774 0.226
E27.9 Disorder of adrenal gland, unspecified
0.000 0.775 0.224
E86 Volume depletion
0.000 0.781 0.219
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.784 0.215
E22.8 Other hyperfunction of pituitary gland
0.000 0.784 0.215
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.000 0.786 0.214
E24.3 Ectopic ACTH syndrome
0.000 0.786 0.214
E24.1 Nelson's syndrome
0.000 0.786 0.214
E84.8 Cystic fibrosis with other manifestations
0.000 0.788 0.212
E84.1 Cystic fibrosis with intestinal manifestations
0.000 0.788 0.212
E84.0 Cystic fibrosis with pulmonary manifestations
0.000 0.788 0.212
D60 Acquired pure red cell aplasia [erythroblastopenia]
0.000 0.788 0.212
E04.1 Non-toxic single thyroid nodule
0.001 0.791 0.208
E72.9 Disorder of amino-acid metabolism, unspecified
0.000 0.792 0.208
E72.8 Other specified disorders of amino-acid metabolism
0.000 0.792 0.208
E72.5 Disorders of glycine metabolism
0.000 0.792 0.208
E72.4 Disorders of ornithine metabolism
0.000 0.792 0.208
E72.3 Disorders of lysine and hydroxylysine metabolism
0.000 0.792 0.208
E72.2 Disorders of urea cycle metabolism
0.000 0.792 0.208
E72.1 Disorders of sulphur-bearing amino-acid metabolism
0.000 0.792 0.208
E24.8 Other Cushing's syndrome
0.000 0.794 0.206
E29.9 Testicular dysfunction, unspecified
0.000 0.796 0.203
E29.8 Other testicular dysfunction
0.000 0.796 0.203
E29.0 Testicular hyperfunction
0.000 0.796 0.203
D56.3 Thalassaemia trait
0.001 0.798 0.201

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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