TreeWAS – Variant ID: rs2541522

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	Risk posterior probability	No effect posterior probability	Protective posterior probability
D51.0 Vitamin B12 deficiency anaemia due to intrinsic factor deficiency	0.148	0.852	0.000
D51 Vitamin B12 deficiency anaemia	0.134	0.866	0.000
D68 Other coagulation defects	0.130	0.870	0.000
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions	0.127	0.873	0.000
D68.9 Coagulation defect, unspecified	0.127	0.873	0.000
D50-D53 Nutritional anaemias	0.124	0.876	0.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	0.123	0.877	0.000
D55-D59 Haemolytic anaemias	0.119	0.881	0.000
D68.2 Hereditary deficiency of other clotting factors	0.117	0.883	0.000
D68.4 Acquired coagulation factor deficiency	0.115	0.885	0.000
D58 Other hereditary haemolytic anaemias	0.113	0.887	0.000
D66 Hereditary factor VIII deficiency	0.112	0.888	0.000
D53 Other nutritional anaemias	0.109	0.891	0.000
D65 Disseminated intravascular coagulation [defibrination syndrome]	0.107	0.893	0.000
D58.0 Hereditary spherocytosis	0.105	0.894	0.000
D59 Acquired haemolytic anaemia	0.101	0.899	0.000
D68.5 Primary Thrombophilia	0.099	0.901	0.000
D51.9 Vitamin B12 deficiency anaemia, unspecified	0.099	0.901	0.000
D68.8 Other specified coagulation defects	0.098	0.902	0.000
D53.9 Nutritional anaemia, unspecified	0.098	0.902	0.000
D68.0 Von Willebrand's disease	0.097	0.903	0.000
D51.8 Other vitamin B12 deficiency anaemias	0.097	0.903	0.000
D51.3 Other dietary vitamin B12 deficiency anaemia	0.097	0.903	0.000
D51.2 Transcobalamin II deficiency	0.097	0.903	0.000
D51.1 Vitamin B12 deficiency anaemia due to selective vitamin B12 malabsorption with proteinuria	0.097	0.903	0.000
D68.1 Hereditary factor XI deficiency	0.096	0.904	0.000
D58.9 Hereditary haemolytic anaemia, unspecified	0.095	0.905	0.000
D67 Hereditary factor IX deficiency	0.095	0.905	0.000
D57 Sickle-cell disorders	0.086	0.914	0.000
D55 Anaemia due to enzyme disorders	0.086	0.914	0.000
D59.4 Other nonautoimmune haemolytic anaemias	0.085	0.915	0.000
D56 Thalassaemia	0.085	0.915	0.000
D68.6 Other Thrombophilia	0.082	0.918	0.000
D58.8 Other specified hereditary haemolytic anaemias	0.081	0.918	0.000
D58.2 Other haemoglobinopathies	0.081	0.918	0.000
D58.1 Hereditary elliptocytosis	0.081	0.918	0.000
D53.8 Other specified nutritional anaemias	0.078	0.922	0.000
D53.2 Scorbutic anaemia	0.078	0.922	0.000
D53.1 Other megaloblastic anaemias, not elsewhere classified	0.078	0.922	0.000
D53.0 Protein deficiency anaemia	0.078	0.922	0.000
D59.1 Other autoimmune haemolytic anaemias	0.076	0.924	0.000
D59.9 Acquired haemolytic anaemia, unspecified	0.075	0.925	0.000
D59.8 Other acquired haemolytic anaemias	0.073	0.927	0.000
D59.6 Haemoglobinuria due to haemolysis from other external causes	0.073	0.927	0.000
D59.5 Paroxysmal nocturnal haemoglobinuria [Marchiafava-Micheli]	0.073	0.927	0.000
D59.3 Haemolytic-uraemic syndrome	0.073	0.927	0.000
D59.2 Drug-induced nonautoimmune haemolytic anaemia	0.073	0.927	0.000
D59.0 Drug-induced autoimmune haemolytic anaemia	0.073	0.927	0.000
D70-D77 Other diseases of blood and blood-forming organs	0.069	0.931	0.000
D80-D89 Certain disorders involving the immune mechanism	0.069	0.931	0.000
D60-D64 Aplastic and other anaemias	0.067	0.933	0.000
D56.1 Beta thalassaemia	0.064	0.936	0.000
D55.9 Anaemia due to enzyme disorder, unspecified	0.061	0.938	0.000
D55.8 Other anaemias due to enzyme disorders	0.061	0.938	0.000
D55.3 Anaemia due to disorders of nucleotide metabolism	0.061	0.938	0.000
D55.2 Anaemia due to disorders of glycolytic enzymes	0.061	0.938	0.000
D55.1 Anaemia due to other disorders of glutathione metabolism	0.061	0.938	0.000
D55.0 Anaemia due to glucose-6-phosphate dehydrogenase [G6PD] deficiency	0.061	0.938	0.000
D57.8 Other sickle-cell disorders	0.061	0.938	0.000
D57.3 Sickle-cell trait	0.061	0.938	0.000
D57.2 Double heterozygous sickling disorders	0.061	0.938	0.000
D57.1 Sickle-cell anaemia without crisis	0.061	0.938	0.000
D57.0 Sickle-cell anaemia with crisis	0.061	0.938	0.000
D56.9 Thalassaemia, unspecified	0.061	0.939	0.000
D56.8 Other thalassaemias	0.061	0.939	0.000
D56.4 Hereditary persistence of foetal haemoglobin [HPFH]	0.061	0.939	0.000
D56.2 Delta-beta thalassaemia	0.061	0.939	0.000
D56.0 Alpha thalassaemia	0.061	0.939	0.000
D63 Anaemia in chronic diseases classified elsewhere	0.061	0.939	0.000
D52 Folate deficiency anaemia	0.059	0.940	0.001
D63.0 Anaemia in neoplastic disease	0.059	0.941	0.000
D68.3 Haemorrhagic disorder due to circulating anticoagulants	0.059	0.941	0.000
D56.3 Thalassaemia trait	0.056	0.943	0.000
D89 Other disorders involving the immune mechanism, not elsewhere classified	0.053	0.947	0.000
D76 Certain diseases involving lymphoreticular tissue and reticulohistiocytic system	0.053	0.947	0.000
D83 Common variable immunodeficiency	0.050	0.950	0.000
D74 Methaemoglobinaemia	0.050	0.950	0.000
D77 Other disorders of blood and blood-forming organs in diseases classified elsewhere	0.050	0.950	0.000
D71 Functional disorders of polymorphonuclear neutrophils	0.050	0.950	0.000
D72 Other disorders of white blood cells	0.050	0.950	0.000
D82 Immunodeficiency associated with other major defects	0.049	0.950	0.000
D81 Combined immunodeficiencies	0.049	0.950	0.000
D84 Other immunodeficiencies	0.049	0.951	0.000
D60 Acquired pure red cell aplasia [erythroblastopenia]	0.048	0.952	0.000
D89.2 Hypergammaglobulinaemia, unspecified	0.046	0.954	0.000
D70 Agranulocytosis	0.046	0.954	0.000
D75 Other diseases of blood and blood-forming organs	0.045	0.955	0.000
D63.1 Anaemia in other chronic diseases classified elsewhere	0.044	0.956	0.000
D52.8 Other folate deficiency anaemias	0.043	0.957	0.001
D52.1 Drug-induced folate deficiency anaemia	0.043	0.957	0.001
D52.0 Dietary folate deficiency anaemia	0.043	0.957	0.001
D72.1 Eosinophilia	0.043	0.957	0.000
D86 Sarcoidosis	0.041	0.959	0.000
D75.1 Secondary polycythaemia	0.041	0.959	0.000
D89.0 Polyclonal hypergammaglobulinaemia	0.041	0.959	0.000
D76.3 Other histiocytosis syndromes	0.041	0.959	0.000
D73 Diseases of spleen	0.040	0.960	0.000
D89.8 Other specified disorders involving the immune mechanism, not elsewhere classified	0.038	0.962	0.000
D89.3 Immune reconstitution syndrome	0.038	0.962	0.000
D76.2 Haemophagocytic syndrome, infection-associated	0.038	0.962	0.000
D76.1 Haemophagocytic lymphohistiocytosis	0.038	0.962	0.000
D76.0 Langerhans' cell histiocytosis, not elsewhere classified	0.038	0.962	0.000
D83.9 Common variable immunodeficiency, unspecified	0.037	0.963	0.000
D83.8 Other common variable immunodeficiencies	0.036	0.964	0.000
D83.2 Common variable immunodeficiency with autoantibodies to B- or T-cells	0.036	0.964	0.000
D83.1 Common variable immunodeficiency with predominant immunoregulatory T-cell disorders	0.036	0.964	0.000
D83.0 Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function	0.036	0.964	0.000
D74.9 Methaemoglobinaemia, unspecified	0.036	0.964	0.000
D74.8 Other methaemoglobinaemias	0.036	0.964	0.000
D74.0 Congenital methaemoglobinaemia	0.036	0.964	0.000
D84.1 Defects in the complement system	0.036	0.964	0.000
D72.9 Disorder of white blood cells, unspecified	0.036	0.964	0.000
D72.0 Genetic anomalies of leukocytes	0.036	0.964	0.000
D81.9 Combined immunodeficiency, unspecified	0.036	0.964	0.000
D81.8 Other combined immunodeficiencies	0.036	0.964	0.000
D81.7 Major histocompatibility complex class II deficiency	0.036	0.964	0.000
D81.6 Major histocompatibility complex class I deficiency	0.036	0.964	0.000
D81.5 Purine nucleoside phosphorylase [PNP] deficiency	0.036	0.964	0.000
D81.4 Nezelof's syndrome	0.036	0.964	0.000
D81.3 Adenosine deaminase [ADA] deficiency	0.036	0.964	0.000
D81.2 Severe combined immunodeficiency [SCID] with low or normal B-cell numbers	0.036	0.964	0.000
D81.1 Severe combined immunodeficiency [SCID] with low T- and B-cell numbers	0.036	0.964	0.000
D81.0 Severe combined immunodeficiency [SCID] with reticular dysgenesis	0.036	0.964	0.000
D82.9 Immunodeficiency associated with major defect, unspecified	0.036	0.964	0.000
D82.8 Immunodeficiency associated with other specified major defects	0.036	0.964	0.000
D82.4 Hyperimmunoglobulin E [IgE] syndrome	0.036	0.964	0.000
D82.3 Immunodeficiency following hereditary defective response to Epstein-Barr virus	0.036	0.964	0.000
D82.2 Immunodeficiency with short-limbed stature	0.036	0.964	0.000
D82.1 Di George's syndrome	0.036	0.964	0.000
D82.0 Wiskott-Aldrich syndrome	0.036	0.964	0.000
D84.8 Other specified immunodeficiencies	0.035	0.965	0.000
D84.0 Lymphocyte function antigen-1 [LFA-1] defect	0.035	0.965	0.000
D86.1 Sarcoidosis of lymph nodes	0.035	0.965	0.000
D60.9 Acquired pure red cell aplasia, unspecified	0.035	0.965	0.000
D60.8 Other acquired pure red cell aplasias	0.035	0.965	0.000
D60.1 Transient acquired pure red cell aplasia	0.035	0.965	0.000
D60.0 Chronic acquired pure red cell aplasia	0.035	0.965	0.000
D61 Other aplastic anaemias	0.035	0.965	0.000
D89.1 Cryoglobulinaemia	0.034	0.966	0.000
D84.9 Immunodeficiency, unspecified	0.034	0.966	0.000
D80 Immunodeficiency with predominantly antibody defects	0.033	0.966	0.000
D75.0 Familial erythrocytosis	0.032	0.968	0.000
D89.9 Disorder involving the immune mechanism, unspecified	0.031	0.968	0.000
D62 Acute posthaemorrhagic anaemia	0.031	0.969	0.000
D73.3 Abscess of spleen	0.031	0.969	0.000
M54.46 Lumbago with sciatica (Lumbar region)	0.000	0.969	0.031
D64 Other anaemias	0.031	0.969	0.000
D69 Purpura and other haemorrhagic conditions	0.030	0.970	0.000
D73.9 Disease of spleen, unspecified	0.030	0.970	0.000
D86.2 Sarcoidosis of lung with sarcoidosis of lymph nodes	0.030	0.970	0.000
D86.8 Sarcoidosis of other and combined sites	0.030	0.970	0.000
D73.0 Hyposplenism	0.030	0.970	0.000
D75.2 Essential thrombocytosis	0.029	0.971	0.000
D73.4 Cyst of spleen	0.029	0.971	0.000
D73.2 Chronic congestive splenomegaly	0.029	0.971	0.000
D63.8 Anaemia in other chronic diseases classified elsewhere	0.028	0.971	0.000
D61.0 Constitutional aplastic anaemia	0.028	0.972	0.000
D73.8 Other diseases of spleen	0.028	0.972	0.000
D86.3 Sarcoidosis of skin	0.028	0.972	0.000
D75.8 Other specified diseases of blood and blood-forming organs	0.027	0.973	0.000
D61.8 Other specified aplastic anaemias	0.025	0.975	0.000
D61.3 Idiopathic aplastic anaemia	0.025	0.975	0.000
D61.2 Aplastic anaemia due to other external agents	0.025	0.975	0.000
D73.1 Hypersplenism	0.025	0.975	0.000
D69.9 Haemorrhagic condition, unspecified	0.025	0.975	0.000
D80.8 Other immunodeficiencies with predominantly antibody defects	0.024	0.976	0.000
D80.7 Transient hypogammaglobulinaemia of infancy	0.024	0.976	0.000
D80.6 Antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinaemia	0.024	0.976	0.000
D80.5 Immunodeficiency with increased immunoglobulin M [IgM]	0.024	0.976	0.000
D80.4 Selective deficiency of immunoglobulin M [IgM]	0.024	0.976	0.000
D80.0 Hereditary hypogammaglobulinaemia	0.024	0.976	0.000
D86.0 Sarcoidosis of lung	0.024	0.976	0.000
D80.3 Selective deficiency of immunoglobulin G [IgG] subclasses	0.024	0.976	0.000
D50 Iron deficiency anaemia	0.024	0.976	0.000
D64.8 Other specified anaemias	0.023	0.977	0.000
D80.9 Immunodeficiency with predominantly antibody defects, unspecified	0.023	0.977	0.000
D64.4 Congenital dyserythropoietic anaemia	0.022	0.978	0.000
D64.3 Other sideroblastic anaemias	0.022	0.978	0.000
D64.2 Secondary sideroblastic anaemia due to drugs and toxins	0.022	0.978	0.000
D64.1 Secondary sideroblastic anaemia due to disease	0.022	0.978	0.000
D64.0 Hereditary sideroblastic anaemia	0.022	0.978	0.000
D80.1 Nonfamilial hypogammaglobulinaemia	0.022	0.978	0.000
D69.8 Other specified haemorrhagic conditions	0.022	0.978	0.000
D69.1 Qualitative platelet defects	0.022	0.978	0.000
D86.9 Sarcoidosis, unspecified	0.022	0.978	0.000
D69.2 Other nonthrombocytopenic purpura	0.021	0.979	0.000
D61.1 Drug-induced aplastic anaemia	0.021	0.979	0.000
D72.8 Other specified disorders of white blood cells	0.021	0.979	0.000
D69.4 Other primary thrombocytopenia	0.020	0.979	0.000
D69.0 Allergic purpura	0.020	0.980	0.000
D69.5 Secondary thrombocytopenia	0.019	0.981	0.000
D73.5 Infarction of spleen	0.019	0.981	0.000
D75.9 Disease of blood and blood-forming organs, unspecified	0.018	0.982	0.000
D80.2 Selective deficiency of immunoglobulin A [IgA]	0.017	0.983	0.001
D50.1 Sideropenic dysphagia	0.017	0.983	0.000
D50.0 Iron deficiency anaemia secondary to blood loss (chronic)	0.017	0.983	0.000
D69.3 Idiopathic thrombocytopenic purpura	0.016	0.984	0.000
M54.4 Lumbago with sciatica	0.000	0.985	0.015
R06.8 Other and unspecified abnormalities of breathing	0.014	0.986	0.000
M54.49 Lumbago with sciatica (Site unspecified)	0.000	0.986	0.014
D52.9 Folate deficiency anaemia, unspecified	0.013	0.986	0.001
H66.9 Otitis media, unspecified	0.000	0.986	0.014
M54.48 Lumbago with sciatica (Sacral and sacrococcygeal region)	0.000	0.989	0.011
M54.45 Lumbago with sciatica (Thoracolumbar region)	0.000	0.989	0.011
M54.44 Lumbago with sciatica-Thoracic	0.000	0.989	0.011
M54.43 Lumbago with sciatica-Cervicothoracic	0.000	0.989	0.011
M54.42 Lumbago with sciatica-Cervical	0.000	0.989	0.011
M54.41 Lumbago with sciatica-Occipit-atl-axl	0.000	0.989	0.011
M54.40 Lumbago with sciatica (Multiple sites in spine)	0.000	0.989	0.011
D61.9 Aplastic anaemia, unspecified	0.011	0.989	0.000
M54.36 Sciatica (Lumbar region)	0.000	0.990	0.010
G35 Multiple sclerosis	0.010	0.990	0.000
S42.30 Fracture of shaft of humerus (closed)	0.000	0.991	0.009
Q64.3 Other atresia and stenosis of urethra and bladder neck	0.009	0.991	0.000
M54.47 Lumbago with sciatica (Lumbosacral region)	0.000	0.992	0.008
Q64 Other congenital malformations of urinary system	0.007	0.993	0.000
C83.1 Small cleaved cell (diffuse)	0.006	0.994	0.000
M20.0 Deformity of finger(s)	0.000	0.994	0.006
I05 Rheumatic mitral valve diseases	0.006	0.994	0.000
G62.9 Polyneuropathy, unspecified	0.006	0.994	0.000
I05.0 Mitral stenosis	0.006	0.994	0.000
C83.8 Other types of diffuse non-Hodgkin's lymphoma	0.006	0.994	0.000
Q12.0 Congenital cataract	0.005	0.994	0.000
C83 Diffuse non-Hodgkin's lymphoma	0.006	0.994	0.000
Q63.0 Accessory kidney	0.005	0.995	0.000
I08.3 Combined disorders of mitral, aortic and tricuspid valves	0.005	0.995	0.000
H90.5 Sensorineural hearing loss, unspecified	0.000	0.995	0.005
I05.1 Rheumatic mitral insufficiency	0.005	0.995	0.000
Q60-Q64 Congenital malformations of the urinary system	0.005	0.995	0.000
I05.9 Mitral valve disease, unspecified	0.005	0.995	0.000
I08.1 Disorders of both mitral and tricuspid valves	0.005	0.995	0.000
Q12 Congenital lens malformations	0.005	0.995	0.000
Q63 Other congenital malformations of kidney	0.005	0.995	0.000
I05.2 Mitral stenosis with insufficiency	0.005	0.995	0.000
Q64.9 Congenital malformation of urinary system, unspecified	0.005	0.995	0.000
Q64.8 Other specified congenital malformations of urinary system	0.005	0.995	0.000
Q64.6 Congenital diverticulum of bladder	0.005	0.995	0.000
Q64.5 Congenital absence of bladder and urethra	0.005	0.995	0.000
Q64.4 Malformation of urachus	0.005	0.995	0.000
Q64.2 Congenital posterior urethral valves	0.005	0.995	0.000
Q64.1 Exstrophy of urinary bladder	0.005	0.995	0.000
Q64.0 Epispadias	0.005	0.995	0.000
I08 Multiple valve diseases	0.005	0.995	0.000
Q64.7 Other congenital malformations of bladder and urethra	0.005	0.995	0.000
Q10-Q18 Congenital malformations of eye, ear, face and neck	0.005	0.995	0.000
G62 Other polyneuropathies	0.005	0.995	0.000
C83.3 Large cell (diffuse)	0.005	0.995	0.000
C83.5 Lymphoblastic (diffuse)	0.005	0.995	0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities	0.005	0.995	0.000
G62.0 Drug-induced polyneuropathy	0.005	0.995	0.000
I05.8 Other mitral valve diseases	0.004	0.995	0.000
H66 Suppurative and unspecified otitis media	0.000	0.996	0.004
S52.10 Fracture of upper end of radius (closed)	0.000	0.996	0.004
I05-I09 Chronic rheumatic heart diseases	0.004	0.996	0.000
Q65-Q79 Congenital malformations and deformations of the musculoskeletal system	0.004	0.996	0.000
C83.6 Undifferentiated (diffuse)	0.004	0.996	0.000
C83.4 Immunoblastic (diffuse)	0.004	0.996	0.000
C83.2 Mixed small and large cell (diffuse)	0.004	0.996	0.000
G62.8 Other specified polyneuropathies	0.004	0.996	0.000
I08.0 Disorders of both mitral and aortic valves	0.004	0.996	0.000
H90.2 Conductive hearing loss, unspecified	0.000	0.996	0.004
C83.0 Small cell (diffuse)	0.004	0.996	0.000
I08.9 Multiple valve disease, unspecified	0.004	0.996	0.000
Q18 Other congenital malformations of face and neck	0.004	0.996	0.000
C83.7 Burkitt's tumour	0.004	0.996	0.000
S42.3 Fracture of shaft of humerus	0.000	0.996	0.004
Q00-Q07 Congenital malformations of the nervous system	0.004	0.996	0.000
C83.9 Diffuse non-Hodgkin's lymphoma, unspecified	0.004	0.996	0.000
R76.8 Other specified abnormal immunological findings in serum	0.004	0.996	0.000
Q62 Congenital obstructive defects of renal pelvis and congenital malformations of ureter	0.004	0.996	0.000
Q15 Other congenital malformations of eye	0.004	0.996	0.000
Q18.0 Sinus, fistula and cyst of branchial cleft	0.004	0.996	0.000
Q65 Congenital deformities of hip	0.004	0.996	0.000
Q12.9 Congenital lens malformation, unspecified	0.004	0.996	0.000
Q12.8 Other congenital lens malformations	0.004	0.996	0.000
Q12.4 Spherophakia	0.004	0.996	0.000
Q12.3 Congenital aphakia	0.004	0.996	0.000
Q12.2 Coloboma of lens	0.004	0.996	0.000
Q12.1 Congenital displaced lens	0.004	0.996	0.000
Q63.9 Congenital malformation of kidney, unspecified	0.004	0.996	0.000
Q63.8 Other specified congenital malformations of kidney	0.004	0.996	0.000
Q63.3 Hyperplastic and giant kidney	0.004	0.996	0.000
Q63.2 Ectopic kidney	0.004	0.996	0.000
Q80-Q89 Other congenital malformations	0.004	0.996	0.000
M20.3 Other deformity of hallux (acquired)	0.004	0.996	0.000
M72.27 Plantar fascial fibromatosis-Ankle/Foot	0.000	0.996	0.004
R74.8 Abnormal levels of other serum enzymes	0.004	0.996	0.000
Q17 Other congenital malformations of ear	0.004	0.996	0.000
D50.8 Other iron deficiency anaemias	0.004	0.996	0.000
Q79 Congenital malformations of musculoskeletal system, not elsewhere classified	0.004	0.996	0.000
H66.1 Chronic tubotympanic suppurative otitis media	0.000	0.996	0.004
Q65.8 Other congenital deformities of hip	0.004	0.996	0.000
Q87 Other specified congenital malformation syndromes affecting multiple systems	0.004	0.996	0.000
Q16 Congenital malformations of ear causing impairment of hearing	0.004	0.996	0.000
Q14 Congenital malformations of posterior segment of eye	0.004	0.996	0.000
Q13 Congenital malformations of anterior segment of eye	0.004	0.996	0.000
Q11 Anophthalmos, microphthalmos and macrophthalmos	0.004	0.996	0.000
R76 Other abnormal immunological findings in serum	0.004	0.996	0.000
Q87.8 Other specified congenital malformation syndromes, not elsewhere classified	0.004	0.996	0.000
Q07 Other congenital malformations of nervous system	0.004	0.996	0.000
H90 Conductive and sensorineural hearing loss	0.000	0.996	0.004
Q90-Q99 Chromosomal abnormalities, not elsewhere classified	0.004	0.996	0.000
Q30-Q34 Congenital malformations of the respiratory system	0.004	0.996	0.000
G62.2 Polyneuropathy due to other toxic agents	0.003	0.996	0.000
H66.4 Suppurative otitis media, unspecified	0.000	0.996	0.004
Q62.1 Atresia and stenosis of ureter	0.003	0.996	0.000
Q63.1 Lobulated, fused and horseshoe kidney	0.003	0.996	0.000
Q70 Syndactyly	0.003	0.996	0.000
Q67 Congenital musculoskeletal deformities of head, face, spine and chest	0.003	0.996	0.000
Q68 Other congenital musculoskeletal deformities	0.003	0.996	0.000
Q35-Q37 Cleft lip and cleft palate	0.003	0.996	0.000
Q79.6 Ehlers-Danlos syndrome	0.003	0.996	0.000
Q83 Congenital malformations of breast	0.003	0.996	0.000
R74 Abnormal serum enzyme levels	0.003	0.996	0.000
I06 Rheumatic aortic valve diseases	0.003	0.997	0.000
Q10 Congenital malformations of eyelid, lachrymal apparatus and orbit	0.003	0.997	0.000
H66.2 Chronic atticoantral suppurative otitis media	0.000	0.997	0.003
I08.2 Disorders of both aortic and tricuspid valves	0.003	0.997	0.000
Q15.0 Congenital glaucoma	0.003	0.997	0.000
G62.1 Alcoholic polyneuropathy	0.003	0.997	0.000
Q05 Spina bifida	0.003	0.997	0.000
Q27 Other congenital malformations of peripheral vascular system	0.003	0.997	0.000
Q77 Osteochondrodysplasia with defects of growth of tubular bones and spine	0.003	0.997	0.000
Q75 Other congenital malformations of skull and face bones	0.003	0.997	0.000
Q73 Reduction defects of unspecified limb	0.003	0.997	0.000
Q72 Reduction defects of lower limb	0.003	0.997	0.000
Q71 Reduction defects of upper limb	0.003	0.997	0.000
Q69 Polydactyly	0.003	0.997	0.000
Q20-Q28 Congenital malformations of the circulatory system	0.003	0.997	0.000
Q07.8 Other specified congenital malformations of nervous system	0.003	0.997	0.000
I38 Endocarditis, valve unspecified	0.000	0.997	0.003
Q04 Other congenital malformations of brain	0.003	0.997	0.000
Q65.2 Congenital dislocation of hip, unspecified	0.003	0.997	0.000
R70-R79 Abnormal findings on examination of blood, without diagnosis	0.003	0.997	0.000
Q18.9 Congenital malformation of face and neck, unspecified	0.003	0.997	0.000
Q18.8 Other specified congenital malformations of face and neck	0.003	0.997	0.000
Q18.7 Microcheilia	0.003	0.997	0.000
Q18.6 Macrocheilia	0.003	0.997	0.000
Q18.5 Microstomia	0.003	0.997	0.000
Q18.4 Macrostomia	0.003	0.997	0.000
Q18.3 Webbing of neck	0.003	0.997	0.000
Q18.2 Other branchial cleft malformations	0.003	0.997	0.000
R76.0 Raised antibody titer	0.003	0.997	0.000
Q06 Other congenital malformations of spinal cord	0.003	0.997	0.000
Q03 Congenital hydrocephalus	0.003	0.997	0.000
Q01 Encephalocele	0.003	0.997	0.000
Q00 Anencephaly and similar malformations	0.003	0.997	0.000
Q02 Microcephaly	0.003	0.997	0.000
R70 Elevated erythrocyte sedimentation rate and abnormality of plasma viscosity	0.003	0.997	0.000
O30.0 Twin pregnancy	0.000	0.997	0.003
Q07.0 Arnold-Chiari syndrome	0.003	0.997	0.000
R70.0 Elevated erythrocyte sedimentation rate	0.003	0.997	0.000
Q78 Other osteochondrodysplasias	0.003	0.997	0.000
H90.7 Mixed conductive and sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side	0.000	0.997	0.003
Q62.8 Other congenital malformations of ureter	0.003	0.997	0.000
Q62.7 Congenital vesico-uretero-renal reflux	0.003	0.997	0.000
Q62.6 Malposition of ureter	0.003	0.997	0.000
Q62.4 Agenesis of ureter	0.003	0.997	0.000
Q62.3 Other obstructive defects of renal pelvis and ureter	0.003	0.997	0.000
Q62.2 Congenital megaloureter	0.003	0.997	0.000
Q62.0 Congenital hydronephrosis	0.003	0.997	0.000
Q15.9 Congenital malformation of eye, unspecified	0.003	0.997	0.000
Q15.8 Other specified congenital malformations of eye	0.003	0.997	0.000
S52.1 Fracture of upper end of radius	0.000	0.997	0.003
Q65.9 Congenital deformity of hip, unspecified	0.003	0.997	0.000
Q65.6 Unstable hip	0.003	0.997	0.000
Q65.5 Congenital subluxation of hip, unspecified	0.003	0.997	0.000
Q65.4 Congenital subluxation of hip, bilateral	0.003	0.997	0.000
Q65.3 Congenital subluxation of hip, unilateral	0.003	0.997	0.000
Q65.1 Congenital dislocation of hip, bilateral	0.003	0.997	0.000
Q65.0 Congenital dislocation of hip, unilateral	0.003	0.997	0.000
H90.6 Mixed conductive and sensorineural hearing loss, bilateral	0.000	0.997	0.003
Q17.5 Prominent ear	0.003	0.997	0.000
Q25 Congenital malformations of great arteries	0.003	0.997	0.000
Q70.3 Webbed toes	0.003	0.997	0.000
R76.9 Abnormal immunological finding in serum, unspecified	0.003	0.997	0.000
Q86 Congenital malformation syndromes due to known exogenous causes, not elsewhere classified	0.003	0.997	0.000
Q84 Other congenital malformations of integument	0.003	0.997	0.000
Q81 Epidermolysis bullosa	0.003	0.997	0.000
Q80 Congenital ichthyosis	0.003	0.997	0.000
Q79.8 Other congenital malformations of musculoskeletal system	0.003	0.997	0.000
Q25.6 Stenosis of pulmonary artery	0.003	0.997	0.000
Q83.8 Other congenital malformations of breast	0.003	0.997	0.000
Q89 Other congenital malformations, not elsewhere classified	0.003	0.997	0.000
Q90 Down's syndrome	0.003	0.997	0.000
R78 Findings of drugs and other substances, not normally found in blood	0.003	0.997	0.000
Q17.9 Congenital malformation of ear, unspecified	0.003	0.997	0.000
Q17.8 Other specified congenital malformations of ear	0.003	0.997	0.000
Q17.4 Misplaced ear	0.003	0.997	0.000
Q17.3 Other misshapen ear	0.003	0.997	0.000
Q17.2 Microtia	0.003	0.997	0.000
Q17.1 Macrotia	0.003	0.997	0.000
Q17.0 Accessory auricle	0.003	0.997	0.000
Q68.8 Other specified congenital musculoskeletal deformities	0.003	0.997	0.000
Q87.4 Marfan's syndrome	0.003	0.997	0.000
Q79.9 Congenital malformation of musculoskeletal system, unspecified	0.003	0.997	0.000
Q79.5 Other congenital malformations of abdominal wall	0.003	0.997	0.000
Q79.4 Prune belly syndrome	0.003	0.997	0.000
Q79.3 Gastroschisis	0.003	0.997	0.000
Q79.2 Exomphalos	0.003	0.997	0.000
Q79.1 Other congenital malformations of diaphragm	0.003	0.997	0.000
Q79.0 Congenital diaphragmatic hernia	0.003	0.997	0.000
Q60 Renal agenesis and other reduction defects of kidney	0.003	0.997	0.000
D03.6 Melanoma in situ of upper limb, including shoulder	0.000	0.997	0.003
H66.0 Acute suppurative otitis media	0.000	0.997	0.003
Q87.5 Other congenital malformation syndromes with other skeletal changes	0.003	0.997	0.000
Q87.3 Congenital malformation syndromes involving early overgrowth	0.003	0.997	0.000
Q87.2 Congenital malformation syndromes predominantly involving limbs	0.003	0.997	0.000
Q87.1 Congenital malformation syndromes predominantly associated with short stature	0.003	0.997	0.000
I09 Other rheumatic heart diseases	0.003	0.997	0.000
Q31 Congenital malformations of larynx	0.003	0.997	0.000
Q66 Congenital deformities of feet	0.003	0.997	0.000
H90.0 Conductive hearing loss, bilateral	0.000	0.997	0.003
Q11.3 Macrophthalmos	0.003	0.997	0.000
Q11.2 Microphthalmos	0.003	0.997	0.000
Q11.1 Other anophthalmos	0.003	0.997	0.000
Q11.0 Cystic eyeball	0.003	0.997	0.000
Q13.9 Congenital malformation of anterior segment of eye, unspecified	0.003	0.997	0.000
Q13.8 Other congenital malformations of anterior segment of eye	0.003	0.997	0.000
Q13.5 Blue sclera	0.003	0.997	0.000
Q13.4 Other congenital corneal malformations	0.003	0.997	0.000
Q13.3 Congenital corneal opacity	0.003	0.997	0.000
Q13.2 Other congenital malformations of iris	0.003	0.997	0.000
Q13.1 Absence of iris	0.003	0.997	0.000
Q13.0 Coloboma of iris	0.003	0.997	0.000
Q14.9 Congenital malformation of posterior segment of eye, unspecified	0.003	0.997	0.000
Q14.8 Other congenital malformations of posterior segment of eye	0.003	0.997	0.000
Q14.3 Congenital malformation of choroid	0.003	0.997	0.000
Q14.2 Congenital malformation of optic disk	0.003	0.997	0.000
Q14.1 Congenital malformation of retina	0.003	0.997	0.000
Q14.0 Congenital malformation of vitreous humour	0.003	0.997	0.000
Q16.9 Congenital malformation of ear causing impairment of hearing, unspecified	0.003	0.997	0.000
Q16.5 Congenital malformation of inner ear	0.003	0.997	0.000
Q16.4 Other congenital malformations of middle ear	0.003	0.997	0.000
Q16.3 Congenital malformation of ear ossicles	0.003	0.997	0.000
Q16.2 Absence of eustachian tube	0.003	0.997	0.000
Q16.1 Congenital absence, atresia and stricture of auditory canal (external)	0.003	0.997	0.000
Q16.0 Congenital absence of (ear) auricle	0.003	0.997	0.000
Q27.8 Other specified congenital malformations of peripheral vascular system	0.003	0.997	0.000
Q27.3 Peripheral arteriovenous malformation	0.003	0.997	0.000
Q87.0 Congenital malformation syndromes predominantly affecting facial appearance	0.003	0.997	0.000
R76.2 False-positive serological test for syphilis	0.003	0.997	0.000
R76.1 Abnormal reaction to tuberculin test	0.003	0.997	0.000
H90.8 Mixed conductive and sensorineural hearing loss, unspecified	0.000	0.997	0.003
M54.3 Sciatica	0.000	0.997	0.003
Q67.6 Pectus excavatum	0.003	0.997	0.000
N94.6 Dysmenorrhoea, unspecified	0.000	0.997	0.003
Q07.9 Congenital malformation of nervous system, unspecified	0.003	0.997	0.000
Q67.5 Congenital deformity of spine	0.003	0.997	0.000
R71 Abnormality of red blood cells	0.003	0.997	0.000
Q83.1 Accessory breast	0.003	0.997	0.000
Q76 Congenital malformations of spine and bony thorax	0.003	0.997	0.000
Q38-Q45 Other congenital malformations of the digestive system	0.003	0.997	0.000
Q34 Other congenital malformations of respiratory system	0.003	0.997	0.000
Q33 Congenital malformations of lung	0.003	0.997	0.000
Q32 Congenital malformations of trachea and bronchus	0.003	0.997	0.000
Q30 Congenital malformations of nose	0.003	0.997	0.000
Q99 Other chromosome abnormalities, not elsewhere classified	0.003	0.997	0.000
Q97 Other sex chromosome abnormalities, female phenotype, not elsewhere classified	0.003	0.997	0.000
Q95 Balanced rearrangements and structural markers, not elsewhere classified	0.003	0.997	0.000
Q93 Monosomies and deletions from the autosomes, not elsewhere classified	0.003	0.997	0.000
Q92 Other trisomies and partial trisomies of the autosomes, not elsewhere classified	0.003	0.997	0.000
Q91 Edwards' syndrome and Patau's syndrome	0.003	0.997	0.000
Q27.9 Congenital malformation of peripheral vascular system, unspecified	0.003	0.997	0.000
Q98 Other sex chromosome abnormalities, male phenotype, not elsewhere classified	0.003	0.997	0.000
R77 Other abnormalities of plasma proteins	0.003	0.997	0.000
F52.2 Failure of genital response	0.000	0.997	0.003
Q83.3 Accessory nipple	0.003	0.997	0.000
G35-G37 Demyelinating diseases of the central nervous system	0.003	0.997	0.000
I06.0 Rheumatic aortic stenosis	0.003	0.997	0.000
Q67.8 Other congenital deformities of chest	0.003	0.997	0.000
Q67.7 Pectus carinatum	0.003	0.997	0.000
Q67.4 Other congenital deformities of skull, face and jaw	0.003	0.997	0.000
Q67.3 Plagiocephaly	0.003	0.997	0.000
Q67.2 Dolichocephaly	0.003	0.997	0.000
Q67.1 Compression facies	0.003	0.997	0.000
Q67.0 Facial asymmetry	0.003	0.997	0.000
Q70.9 Syndactyly, unspecified	0.003	0.997	0.000
Q70.4 Polysyndactyly	0.003	0.997	0.000
Q70.2 Fused toes	0.003	0.997	0.000
Q70.1 Webbed fingers	0.003	0.997	0.000
Q70.0 Fused fingers	0.003	0.997	0.000
M23.26 Derangement of meniscus due to old tear or injury (Other and unspecified lateral meniscus)	0.000	0.997	0.003
K43.0 Ventral hernia with obstruction, without gangrene	0.003	0.997	0.000
Q68.5 Congenital bowing of long bones of leg, unspecified	0.003	0.997	0.000
Q68.4 Congenital bowing of tibia and fibula	0.003	0.997	0.000
Q68.3 Congenital bowing of femur	0.003	0.997	0.000
Q68.2 Congenital deformity of knee	0.003	0.997	0.000
Q68.1 Congenital deformity of hand	0.003	0.997	0.000
Q68.0 Congenital deformity of sternocleidomastoid muscle	0.003	0.997	0.000
Q37 Cleft palate with cleft lip	0.003	0.997	0.000
Q36 Cleft lip	0.003	0.997	0.000
Q35 Cleft palate	0.003	0.997	0.000
Q83.9 Congenital malformation of breast, unspecified	0.003	0.997	0.000
Q83.2 Absent nipple	0.003	0.997	0.000
Q83.0 Congenital absence of breast with absent nipple	0.003	0.997	0.000
R74.9 Abnormal level of unspecified serum enzyme	0.003	0.997	0.000
R78.0 Finding of alcohol in blood	0.003	0.997	0.000
Q96 Turner's syndrome	0.003	0.997	0.000
Q66.3 Other congenital varus deformities of feet	0.003	0.997	0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations