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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs2596473
log Bayes Factor = 136.398
Chromosome 6   position 31,430,799  (GRCh37) Explore rs2596473 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E05.9 Thyrotoxicosis, unspecified
0.000 0.000 1.000
E10.9 Without complications
0.000 0.000 1.000
E10.3 With ophthalmic complications
0.000 0.000 1.000
K90.0 Coeliac disease
0.000 0.000 1.000
M45.X9 Ankylosing spondylitis (Site unspecified)
1.000 0.000 0.000
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
G35 Multiple sclerosis
0.000 0.000 1.000
E00-E07 Disorders of thyroid gland
0.000 0.000 1.000
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.000 1.000
E10-E14 Diabetes mellitus
0.000 0.000 1.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.000 1.000
E03 Other hypothyroidism
0.000 0.000 1.000
E03.9 Hypothyroidism, unspecified
0.000 0.001 0.999
E10.1 With ketoacidosis
0.000 0.001 0.999
M45 Ankylosing spondylitis
0.998 0.002 0.000
L40.9 Psoriasis, unspecified
0.997 0.003 0.000
E10.2 With renal complications
0.000 0.003 0.997
M45.X0 Ankylosing spondylitis (Multiple sites in spine)
0.995 0.005 0.000
H36.0 Diabetic retinopathy
0.000 0.009 0.991
E10.4 With neurological complications
0.000 0.010 0.990
E50-E64 Other nutritional deficiencies
0.000 0.022 0.978
G35-G37 Demyelinating diseases of the central nervous system
0.000 0.027 0.973
E53 Deficiency of other B group vitamins
0.000 0.032 0.968
E14 Unspecified diabetes mellitus
0.000 0.033 0.967
G37 Other demyelinating diseases of central nervous system
0.000 0.034 0.966
G37.9 Demyelinating disease of central nervous system, unspecified
0.000 0.043 0.957
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.045 0.955
E53.8 Deficiency of other specified B group vitamins
0.000 0.051 0.949
M45.X2 Ankylosing spondylitis (Cervical region)
0.942 0.058 0.000
E14.3 With ophthalmic complications
0.000 0.063 0.937
E16 Other disorders of pancreatic internal secretion
0.000 0.077 0.923
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.110 0.890
E16.2 Hypoglycaemia, unspecified
0.000 0.114 0.886
E10.0 With coma
0.000 0.115 0.885
E06 Thyroiditis
0.000 0.119 0.881
E53.9 Vitamin B deficiency, unspecified
0.000 0.132 0.868
E11 Non-insulin-dependent diabetes mellitus
0.000 0.137 0.863
E11.3 With ophthalmic complications
0.000 0.146 0.854
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.161 0.839
E10.5 With peripheral circulatory complications
0.000 0.163 0.837
E55 Vitamin D deficiency
0.000 0.184 0.816
E06.3 Autoimmune thyroiditis
0.000 0.190 0.810
G37.3 Acute transverse myelitis in demyelinating disease of central nervous system
0.000 0.191 0.809
M45.X7 Ankylosing spondylitis (Lumbosacral region)
0.799 0.201 0.000
K90 Intestinal malabsorption
0.000 0.205 0.795
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.206 0.794
E40-E46 Malnutrition
0.000 0.210 0.789
E03.8 Other specified hypothyroidism
0.000 0.214 0.786
E10.6 With other specified complications
0.000 0.215 0.785
E14.2 Withrenal complications
0.000 0.220 0.780
E14.6 With other specified complications
0.000 0.228 0.772
H36 Retinal disorders in diseases classified elsewhere
0.000 0.229 0.771
G36 Other acute disseminated demyelination
0.000 0.229 0.771
E14.1 With ketoacidosis
0.000 0.233 0.767
E14.8 With unspecified complications
0.000 0.234 0.766
M45.X6 Ankylosing spondylitis (Lumbar region)
0.751 0.249 0.000
E51 Thiamine deficiency
0.000 0.249 0.751
E11.1 With ketoacidosis
0.000 0.251 0.749
E10.8 With unspecified complications
0.000 0.256 0.744
M35.0 Sicca syndrome [Sjogren]
0.000 0.265 0.735
K90.9 Intestinal malabsorption, unspecified
0.000 0.283 0.717
E05.5 Thyroid crisis or storm
0.000 0.283 0.717
E05.4 Thyrotoxicosis factitia
0.000 0.283 0.717
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.283 0.717
E10.7 With multiple complications
0.000 0.283 0.717
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.283 0.717
E00 Congenital iodine-deficiency syndrome
0.000 0.283 0.717
E12 Malnutrition-related diabetes mellitus
0.000 0.283 0.717
E03.5 Myxoedema coma
0.000 0.283 0.717
E03.4 Atrophy of thyroid (acquired)
0.000 0.283 0.717
E03.3 Postinfectious hypothyroidism
0.000 0.283 0.717
M45.X8 Ankylosing spondylitis (Sacral and sacrococcygeal region)
0.716 0.284 0.000
M45.X5 Ankylosing spondylitis (Thoracolumbar region)
0.716 0.284 0.000
M45.X4 Ankylosing spondylitis (Thoracic region)
0.716 0.284 0.000
M45.X3 Ankylosing spondylitis (Cervicothoracic region)
0.716 0.284 0.000
M45.X1 Ankylosing spondylitis (Occipito-atlanto-axial region)
0.716 0.284 0.000
E20-E35 Disorders of other endocrine glands
0.000 0.285 0.715
E27 Other disorders of adrenal gland
0.000 0.295 0.705
E06.9 Thyroiditis, unspecified
0.000 0.297 0.703
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.298 0.701
E63 Other nutritional deficiencies
0.000 0.298 0.701
E50 Vitamin A deficiency
0.000 0.298 0.701
E60 Dietary zinc deficiency
0.000 0.298 0.701
E59 Dietary selenium deficiency
0.000 0.298 0.701
E52 Niacin deficiency [pellagra]
0.000 0.298 0.701
G37.8 Other specified demyelinating diseases of central nervous system
0.000 0.300 0.700
E55.9 Vitamin D deficiency, unspecified
0.000 0.300 0.700
E14.4 With neurological complications
0.000 0.300 0.700
E14.5 With peripheral circulatory complications
0.000 0.302 0.698
E11.8 With unspecified complications
0.000 0.304 0.696
E53.1 Pyridoxine deficiency
0.000 0.306 0.694
E53.0 Riboflavin deficiency
0.000 0.306 0.694
E14.7 With multiple complications
0.000 0.307 0.693
E14.0 With coma
0.000 0.307 0.693
G37.5 Concentric sclerosis [Balo]
0.000 0.307 0.692
G37.4 Subacute necrotising myelitis
0.000 0.307 0.692
G37.2 Central pontine myelinolysis
0.000 0.307 0.692
G37.1 Central demyelination of corpus callosum
0.000 0.307 0.692
G37.0 Diffuse sclerosis
0.000 0.307 0.692
E05.8 Other thyrotoxicosis
0.000 0.310 0.690
E27.1 Primary adrenocortical insufficiency
0.000 0.311 0.689
E15 Nondiabetic hypoglycaemic coma
0.000 0.315 0.685
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.316 0.684
E03.1 Congenital hypothyroidism without goitre
0.000 0.321 0.679
E11.6 With other specified complications
0.000 0.334 0.666
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.000 0.337 0.663
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.337 0.662
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.338 0.661
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.338 0.661
E16.4 Abnormal secretion of gastrin
0.000 0.338 0.661
E16.3 Increased secretion of glucagon
0.000 0.338 0.661
E54 Ascorbic acid deficiency
0.000 0.354 0.646
E46 Unspecified protein-energy malnutrition
0.000 0.361 0.639
E06.4 Drug-induced thyroiditis
0.000 0.368 0.632
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.368 0.632
E06.0 Acute thyroiditis
0.000 0.368 0.632
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.371 0.628
E58 Dietary calcium deficiency
0.000 0.372 0.628
G36.0 Neuromyelitis optica [Devic]
0.000 0.374 0.626
E11.7 With multiple complications
0.000 0.381 0.619
H30-H36 Disorders of choroid and retina
0.000 0.387 0.613
E20 Hypoparathyroidism
0.000 0.390 0.610
H34 Retinal vascular occlusions
0.000 0.401 0.599
E51.2 Wernicke's encephalopathy
0.000 0.413 0.587
E55.0 Rickets, active
0.000 0.415 0.585
E61 Deficiency of other nutrient elements
0.000 0.417 0.583
L40 Psoriasis
0.581 0.419 0.000
E27.3 Drug-induced adrenocortical insufficiency
0.000 0.425 0.575
K90.8 Other intestinal malabsorption
0.000 0.425 0.575
E56 Other vitamin deficiencies
0.000 0.426 0.573
K90.3 Pancreatic steatorrhoea
0.000 0.430 0.570
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.430 0.570
K90.1 Tropical sprue
0.000 0.430 0.570
E06.5 Other chronic thyroiditis
0.000 0.431 0.569
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.434 0.566
E45 Retarded development following protein-energy malnutrition
0.000 0.434 0.566
E43 Unspecified severe protein-energy malnutrition
0.000 0.434 0.566
E42 Marasmic kwashiorkor
0.000 0.434 0.566
E41 Nutritional marasmus
0.000 0.434 0.566
E40 Kwashiorkor
0.000 0.434 0.566
E27.8 Other specified disorders of adrenal gland
0.000 0.437 0.563
H34.2 Other retinal artery occlusions
0.000 0.437 0.563
E27.4 Other and unspecified adrenocortical insufficiency
0.000 0.442 0.558
H36.8 Other retinal disorders in diseases classified elsewhere
0.000 0.447 0.553
G36.9 Acute disseminated demyelination, unspecified
0.000 0.447 0.553
G36.8 Other specified acute disseminated demyelination
0.000 0.447 0.553
G36.1 Acute and subacute haemorrhagic leukoencephalitis [Hurst]
0.000 0.447 0.553
E06.1 Subacute thyroiditis
0.000 0.448 0.552
H34.8 Other retinal vascular occlusions
0.000 0.452 0.548
E20.9 Hypoparathyroidism, unspecified
0.000 0.454 0.546
H30 Chorioretinal inflammation
0.000 0.454 0.546
E31 Polyglandular dysfunction
0.000 0.458 0.542
E24 Cushing's syndrome
0.000 0.461 0.539
E51.9 Thiamine deficiency, unspecified
0.000 0.462 0.538
E51.8 Other manifestations of thiamine deficiency
0.000 0.462 0.538
E51.1 Beriberi
0.000 0.462 0.538
E65-E68 Obesity and other hyperalimentation
0.000 0.463 0.537
H31 Other disorders of choroid
0.000 0.481 0.519
E11.5 With peripheral circulatory complications
0.000 0.481 0.519
L40.8 Other psoriasis
0.519 0.481 0.000
E11.0 With coma
0.000 0.485 0.515
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.000 0.486 0.514
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.000 0.486 0.514
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.000 0.486 0.514
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.000 0.486 0.514
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.486 0.514
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.000 0.486 0.514
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.000 0.486 0.514
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.000 0.486 0.514
E12.9 Without complications
0.000 0.486 0.514
E12.8 With unspecified complications
0.000 0.486 0.514
E12.7 With multiple complications
0.000 0.486 0.514
E12.6 With other specified complications
0.000 0.486 0.514
E12.5 With peripheral circulatory complications
0.000 0.486 0.514
E12.4 With neurological complications
0.000 0.486 0.514
E12.3 With ophthalmic complications
0.000 0.486 0.514
E12.2 With renal complications
0.000 0.486 0.514
E12.1 With ketoacidosis
0.000 0.486 0.514
E12.0 With coma
0.000 0.486 0.514
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.488 0.512
E32 Diseases of thymus
0.000 0.488 0.512
E30 Disorders of puberty, not elsewhere classified
0.000 0.488 0.512
E13 Other specified diabetes mellitus
0.000 0.488 0.511
E27.2 Addisonian crisis
0.000 0.489 0.511
E27.5 Adrenomedullary hyperfunction
0.000 0.494 0.505
E27.0 Other adrenocortical overactivity
0.000 0.494 0.505
E25 Adrenogenital disorders
0.000 0.495 0.505
E50.9 Vitamin A deficiency, unspecified
0.000 0.497 0.503
E50.8 Other manifestations of vitamin A deficiency
0.000 0.497 0.503
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.497 0.503
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.497 0.503
E50.5 Vitamin A deficiency with night blindness
0.000 0.497 0.503
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.497 0.503
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.497 0.503
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.497 0.503
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.497 0.503
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.497 0.503
E63.9 Nutritional deficiency, unspecified
0.000 0.497 0.503
E63.8 Other specified nutritional deficiencies
0.000 0.497 0.503
E63.1 Imbalance of constituents of food intake
0.000 0.497 0.503
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.497 0.503
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.497 0.503
E64.8 Sequelae of other nutritional deficiencies
0.000 0.497 0.503
E64.3 Sequelae of rickets
0.000 0.497 0.503
E64.2 Sequelae of vitamin C deficiency
0.000 0.497 0.503
E64.1 Sequelae of vitamin A deficiency
0.000 0.497 0.503
E64.0 Sequelae of protein-energy malnutrition
0.000 0.497 0.503
I10 Essential (primary) hypertension
0.493 0.507 0.000
H30.9 Chorioretinal inflammation, unspecified
0.000 0.509 0.491
H31.0 Chorioretinal scars
0.000 0.516 0.484
E61.2 Magnesium deficiency
0.000 0.528 0.471
E26 Hyperaldosteronism
0.000 0.533 0.466
E07 Other disorders of thyroid
0.000 0.544 0.456
H34.1 Central retinal artery occlusion
0.000 0.552 0.448
H32 Chorioretinal disorders in diseases classified elsewhere
0.000 0.560 0.440
E11.2 With renal complications
0.000 0.560 0.440
L40.1 Generalised pustular psoriasis
0.439 0.561 0.000
E20.1 Pseudohypoparathyroidism
0.000 0.562 0.438
E20.0 Idiopathic hypoparathyroidism
0.000 0.562 0.438
L40.5 Arthropathic psoriasis
0.435 0.565 0.000
E27.9 Disorder of adrenal gland, unspecified
0.000 0.569 0.431
H34.0 Transient retinal artery occlusion
0.000 0.570 0.430
H34.9 Retinal vascular occlusion, unspecified
0.000 0.576 0.424
E31.0 Autoimmune polyglandular failure
0.000 0.581 0.418
E61.9 Deficiency of nutrient element, unspecified
0.000 0.582 0.418
E61.8 Deficiency of other specified nutrient elements
0.000 0.582 0.418
E61.7 Deficiency of multiple nutrient elements
0.000 0.582 0.418
E61.6 Vanadium deficiency
0.000 0.582 0.418
E61.5 Molybdenum deficiency
0.000 0.582 0.418
E61.4 Chromium deficiency
0.000 0.582 0.418
E61.3 Manganese deficiency
0.000 0.582 0.418
E61.0 Copper deficiency
0.000 0.582 0.418
E24.8 Other Cushing's syndrome
0.000 0.582 0.418
L40.2 Acrodermatitis continua
0.417 0.583 0.000
E56.9 Vitamin deficiency, unspecified
0.000 0.588 0.411
E56.8 Deficiency of other vitamins
0.000 0.588 0.411
E56.0 Deficiency of vitamin E
0.000 0.588 0.411
H30.2 Posterior cyclitis
0.000 0.589 0.411
E20.8 Other hypoparathyroidism
0.000 0.592 0.408
E44.1 Mild protein-energy malnutrition
0.000 0.594 0.406
E44.0 Moderate protein-energy malnutrition
0.000 0.594 0.406
E28 Ovarian dysfunction
0.003 0.594 0.403
E16.1 Other hypoglycaemia
0.001 0.596 0.404
E24.2 Drug-induced Cushing's syndrome
0.000 0.604 0.396
H30.8 Other chorioretinal inflammations
0.000 0.608 0.392
H30.1 Disseminated chorioretinal inflammation
0.000 0.608 0.392
H30.0 Focal chorioretinal inflammation
0.000 0.608 0.392
E31.9 Polyglandular dysfunction, unspecified
0.000 0.611 0.389
E31.8 Other polyglandular dysfunction
0.000 0.611 0.389
E31.1 Polyglandular hyperfunction
0.000 0.611 0.389
L40.4 Guttate psoriasis
0.386 0.613 0.000
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.000 0.614 0.386
E24.3 Ectopic ACTH syndrome
0.000 0.614 0.386
E24.1 Nelson's syndrome
0.000 0.614 0.386
E67 Other hyperalimentation
0.000 0.614 0.385
E68 Sequelae of hyperalimentation
0.000 0.614 0.385
E24.0 Pituitary-dependent Cushing's disease
0.000 0.615 0.385
H31.8 Other specified disorders of choroid
0.000 0.623 0.377
E22 Hyperfunction of pituitary gland
0.000 0.627 0.373
H31.4 Choroidal detachment
0.000 0.628 0.372
H31.2 Hereditary choroidal dystrophy
0.000 0.628 0.372
E24.9 Cushing's syndrome, unspecified
0.000 0.629 0.371
L40.3 Pustulosis palmaris et plantaris
0.369 0.630 0.000
E30.9 Disorder of puberty, unspecified
0.000 0.632 0.367
E30.8 Other disorders of puberty
0.000 0.632 0.367
E30.1 Precocious puberty
0.000 0.632 0.367
E30.0 Delayed puberty
0.000 0.632 0.367
E32.9 Disease of thymus, unspecified
0.000 0.632 0.367
E32.8 Other diseases of thymus
0.000 0.632 0.367
E32.1 Abscess of thymus
0.000 0.632 0.367
E32.0 Persistent hyperplasia of thymus
0.000 0.632 0.367
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.632 0.367
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.632 0.367
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.632 0.367
E13.8 With unspecified complications
0.000 0.633 0.367
E13.7 With multiple complications
0.000 0.633 0.367
E13.6 With other specified complications
0.000 0.633 0.367
E13.5 With peripheral circulatory complications
0.000 0.633 0.367
E13.4 With neurological complications
0.000 0.633 0.367
E13.2 With renal complications
0.000 0.633 0.367
E13.1 With ketoacidosis
0.000 0.633 0.367
E13.0 With coma
0.000 0.633 0.367
E13.3 With ophthalmic complications
0.000 0.636 0.364
H31.3 Choroidal haemorrhage and rupture
0.000 0.637 0.363
E25.9 Adrenogenital disorder, unspecified
0.000 0.638 0.362
E25.8 Other adrenogenital disorders
0.000 0.638 0.362
E34 Other endocrine disorders
0.000 0.640 0.360
H31.9 Disorder of choroid, unspecified
0.000 0.644 0.356
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.000 0.645 0.355
E26.9 Hyperaldosteronism, unspecified
0.000 0.654 0.346
E29 Testicular dysfunction
0.001 0.658 0.341
E28.3 Primary ovarian failure
0.001 0.664 0.334
E26.8 Other hyperaldosteronism
0.000 0.665 0.334
E26.1 Secondary hyperaldosteronism
0.000 0.665 0.334
E07.1 Dyshormogenetic goitre
0.000 0.673 0.327
E07.0 Hypersecretion of calcitonin
0.000 0.673 0.327
E66 Obesity
0.000 0.679 0.321
L40.0 Psoriasis vulgaris
0.320 0.680 0.000
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.000 0.684 0.316
H32.8 Other chorioretinal disorders in diseases classified elsewhere
0.000 0.684 0.315
H32.0 Chorioretinal inflammation in infectious and parasitic diseases classified elsewhere
0.000 0.684 0.315
E22.1 Hyperprolactinaemia
0.000 0.692 0.308
E65 Localised adiposity
0.000 0.696 0.304
E28.9 Ovarian dysfunction, unspecified
0.002 0.709 0.289
E28.8 Other ovarian dysfunction
0.002 0.709 0.289
E28.1 Androgen excess
0.002 0.709 0.289
E28.0 Oestrogen excess
0.002 0.709 0.289
E66.8 Other obesity
0.000 0.715 0.285
E56.1 Deficiency of vitamin K
0.001 0.716 0.283
E67.8 Other specified hyperalimentation
0.000 0.723 0.276
E67.3 Hypervitaminosis D
0.000 0.723 0.276
E67.2 Megavitamin-B6 syndrome
0.000 0.723 0.276
E67.1 Hypercarotenaemia
0.000 0.723 0.276
E67.0 Hypervitaminosis A
0.000 0.723 0.276
E26.0 Primary hyperaldosteronism
0.000 0.727 0.272
H31.1 Choroidal degeneration
0.000 0.728 0.272
E07.8 Other specified disorders of thyroid
0.000 0.731 0.269
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.732 0.267
E22.8 Other hyperfunction of pituitary gland
0.000 0.732 0.267
E34.3 Short stature, not elsewhere classified
0.000 0.741 0.259
E34.5 Androgen resistance syndrome
0.000 0.741 0.258
E34.4 Constitutional tall stature
0.000 0.741 0.258
E34.2 Ectopic hormone secretion, not elsewhere classified
0.000 0.741 0.258
E34.1 Other hypersecretion of intestinal hormones
0.000 0.741 0.258
E66.0 Obesity due to excess calories
0.000 0.742 0.258
E29.9 Testicular dysfunction, unspecified
0.001 0.755 0.245
E29.8 Other testicular dysfunction
0.001 0.755 0.245
E29.0 Testicular hyperfunction
0.001 0.755 0.245
E21.4 Other specified disorders of parathyroid gland
0.000 0.756 0.244
E34.8 Other specified endocrine disorders
0.000 0.767 0.233
E66.1 Drug-induced obesity
0.000 0.769 0.231
E34.9 Endocrine disorder, unspecified
0.000 0.772 0.228
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.000 0.772 0.228
E23 Hypofunction and other disorders of pituitary gland
0.000 0.772 0.227
E21.2 Other hyperparathyroidism
0.000 0.785 0.215
E22.0 Acromegaly and pituitary gigantism
0.000 0.790 0.210
E34.0 Carcinoid syndrome
0.000 0.798 0.202
E21.0 Primary hyperparathyroidism
0.000 0.810 0.190
E07.9 Disorder of thyroid, unspecified
0.000 0.813 0.187
E21.5 Disorder of parathyroid gland, unspecified
0.000 0.819 0.181
E66.2 Extreme obesity with alveolar hypoventilation
0.000 0.831 0.169
E13.9 Without complications
0.001 0.831 0.168
E21.3 Hyperparathyroidism, unspecified
0.000 0.834 0.166
L40-L45 Papulosquamous disorders
0.164 0.835 0.001
E23.1 Drug-induced hypopituitarism
0.000 0.837 0.163
E61.1 Iron deficiency
0.000 0.837 0.163
M35 Other systemic involvement of connective tissue
0.000 0.837 0.163
E23.2 Diabetes insipidus
0.000 0.843 0.157
E23.7 Disorder of pituitary gland, unspecified
0.000 0.843 0.157
E23.6 Other disorders of pituitary gland
0.000 0.850 0.149
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.000 0.854 0.145
L41 Parapsoriasis
0.132 0.868 0.001
E04 Other non-toxic goitre
0.000 0.875 0.125
M45-M49 Spondylopathies
0.123 0.877 0.000
L44 Other papulosquamous disorders
0.118 0.881 0.001
L45 Papulosquamous disorders in diseases classified elsewhere
0.118 0.882 0.001
M35.9 Systemic involvement of connective tissue, unspecified
0.000 0.883 0.117
M35.6 Relapsing panniculitis [Weber-Christian]
0.000 0.883 0.117
M35.5 Multifocal fibrosclerosis
0.000 0.883 0.117
M35.4 Diffuse (eosinophilic) fasciitis
0.000 0.883 0.117
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.000 0.883 0.116
L42 Pityriasis rosea
0.116 0.883 0.001
M35.1 Other overlap syndromes
0.000 0.887 0.113
M35.8 Other specified systemic involvement of connective tissue
0.000 0.887 0.112
L41.1 Pityriasis lichenoides chronica
0.109 0.891 0.000
M35.7 Hypermobility syndrome
0.000 0.891 0.109
M35.2 Behcet's disease
0.000 0.895 0.104
E14.9 Without complications
0.000 0.896 0.104
E11.4 With neurological complications
0.001 0.899 0.101
M49 Spondylopathies in diseases classified elsewhere
0.100 0.900 0.000
E04.0 Non-toxic diffuse goitre
0.000 0.903 0.097
L41.9 Parapsoriasis, unspecified
0.095 0.905 0.001
L41.8 Other parapsoriasis
0.095 0.905 0.001
L41.5 Retiform parapsoriasis
0.095 0.905 0.001
L41.4 Large plaque parapsoriasis
0.095 0.905 0.001
L41.3 Small plaque parapsoriasis
0.095 0.905 0.001
L41.2 Lymphomatoid papulosis
0.095 0.905 0.001
L41.0 Pityriasis lichenoides et varioliformis acuta
0.095 0.905 0.001
M35.3 Polymyalgia rheumatica
0.000 0.905 0.095
I10-I15 Hypertensive diseases
0.093 0.907 0.000
D61.9 Aplastic anaemia, unspecified
0.000 0.909 0.091
E04.8 Other specified non-toxic goitre
0.000 0.910 0.090
H33 Retinal detachments and breaks
0.000 0.912 0.088
M46 Other inflammatory spondylopathies
0.088 0.912 0.000
L44.0 Pityriasis rubra pilaris
0.085 0.914 0.001
L44.9 Papulosquamous disorder, unspecified
0.085 0.915 0.001
L44.8 Other specified papulosquamous disorders
0.085 0.915 0.001
L44.4 Infantile papular acrodermatitis [Giannotti-Crosti]
0.085 0.915 0.001
L44.3 Lichen ruber moniliformis
0.085 0.915 0.001
L44.2 Lichen striatus
0.085 0.915 0.001
L44.1 Lichen nitidus
0.085 0.915 0.001
M35.99 Systemic involvement of connective tissue, unspecified, Site unspecified
0.000 0.916 0.084
M49.5 Collapsed vertebra in diseases classified elsewhere
0.083 0.917 0.000
M46.4 Discitis, unspecified
0.079 0.921 0.000
D61 Other aplastic anaemias
0.000 0.921 0.079
H33.4 Traction detachment of retina
0.000 0.922 0.078
M46.46 Discitis, unspecified (Lumbar region)
0.075 0.924 0.000
I13 Hypertensive heart and renal disease
0.075 0.925 0.000
E29.1 Testicular hypofunction
0.001 0.925 0.074
M49.8 Spondylopathy in other diseases classified elsewhere
0.072 0.928 0.000
M49.4 Neuropathic spondylopathy
0.072 0.928 0.000
M49.3 Spondylopathy in other infectious and parasitic diseases classified elsewhere
0.072 0.928 0.000
M49.2 Enterobacterial spondylitis
0.072 0.928 0.000
M49.1 Brucella spondylitis
0.072 0.928 0.000
M49.0 Tuberculosis of spine
0.072 0.928 0.000
M49.54 Collapsed vertebra in diseases classified elsewhere (Thoracic region)
0.072 0.928 0.000
M46.3 Infection of intervertebral disk (pyogenic)
0.066 0.934 0.000
I15 Secondary hypertension
0.064 0.936 0.000
D61.0 Constitutional aplastic anaemia
0.000 0.936 0.063
M46.8 Other specified inflammatory spondylopathies
0.063 0.937 0.000
M46.5 Other infective spondylopathies
0.063 0.937 0.000
M49.50 Collapsed vertebra in diseases classified elsewhere (Multiple sites in spine)
0.063 0.937 0.000
M46.2 Osteomyelitis of vertebra
0.063 0.937 0.000
D61.1 Drug-induced aplastic anaemia
0.000 0.937 0.063
I13.9 Hypertensive heart and renal disease, unspecified
0.062 0.937 0.000
D60-D64 Aplastic and other anaemias
0.000 0.938 0.062
M49.59 Collapsed vertebra in diseases classified elsewhere (Site unspecified)
0.060 0.940 0.000
M49.58 Collapsed vertebra in diseases classified elsewhere (Sacral and sacrococcygeal region)
0.060 0.940 0.000
M49.57 Collapsed vertebra in diseases classified elsewhere (Lumbosacral region)
0.060 0.940 0.000
M49.55 Collapsed vertebra in diseases classified elsewhere (Thoracolumbar region)
0.060 0.940 0.000
M49.53 Collapsed vertebra in diseases classified elsewhere (Cervicothoracic region)
0.060 0.940 0.000
M49.52 Collapsed vertebra in diseases classified elsewhere (Cervical region)
0.060 0.940 0.000
M49.51 Collapsed vertebra in diseases classified elsewhere (Occipito-atlanto-axial region)
0.060 0.940 0.000
M46.1 Sacro-iliitis, not elsewhere classified
0.058 0.942 0.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.000 0.943 0.057
M46.48 Discitis, unspecified (Sacral and sacrococcygeal region)
0.057 0.943 0.000
M46.45 Discitis, unspecified (Thoracolumbar region)
0.057 0.943 0.000
M46.43 Discitis, unspecified (Cervicothoracic region)
0.057 0.943 0.000
M46.41 Discitis, unspecified (Occipito-atlanto-axial region)
0.057 0.943 0.000
M46.40 Discitis, unspecified (Multiple sites in spine)
0.057 0.943 0.000
D61.8 Other specified aplastic anaemias
0.000 0.943 0.057
D61.3 Idiopathic aplastic anaemia
0.000 0.943 0.057
D61.2 Aplastic anaemia due to other external agents
0.000 0.943 0.057
I15.9 Seconday hypertension, unspecified
0.056 0.944 0.000
M49.56 Collapsed vertebra in diseases classified elsewhere (Lumbar region)
0.056 0.944 0.000
M46.44 Discitis, unspecified (Thoracic region)
0.055 0.945 0.000
M46.49 Discitis, unspecified (Site unspecified)
0.055 0.945 0.000
M46.47 Discitis, unspecified (Lumbosacral region)
0.055 0.945 0.000
I13.2 Hypertensive heart and renal disease with both (congestive) heart failure and renal failure
0.054 0.946 0.000
I13.1 Hypertensive heart and renal disease with renal failure
0.054 0.946 0.000
I13.0 Hypertensive heart and renal disease with (congestive) heart failure
0.054 0.946 0.000
M46.0 Spinal enthesopathy
0.054 0.946 0.000
D50-D53 Nutritional anaemias
0.000 0.947 0.053
M46.42 Discitis, unspecified (Cervical region)
0.053 0.947 0.000
M49.09 Tuberculosis of spine (Site unspecified)
0.052 0.948 0.000
M49.08 Tuberculosis of spine (Sacral and sacrococcygeal region)
0.052 0.948 0.000
M49.07 Tuberculosis of spine (Lumbosacral region)
0.052 0.948 0.000
M49.06 Tuberculosis of spine (Lumbar region)
0.052 0.948 0.000
M49.05 Tuberculosis of spine (Thoracolumbar region)
0.052 0.948 0.000
M49.04 Tuberculosis of spine (Thoracic region)
0.052 0.948 0.000
M49.03 Tuberculosis of spine (Cervicothoracic region)
0.052 0.948 0.000
M49.02 Tuberculosis of spine (Cervical region)
0.052 0.948 0.000
M49.01 Tuberculosis of spine (Occipito-atlanto-axial region)
0.052 0.948 0.000
M49.00 Tuberculosis of spine (Multiple sites in spine)
0.052 0.948 0.000
M49.19 Brucella spondylitis (Site unspecified)
0.052 0.948 0.000
M49.18 Brucella spondylitis (Sacral and sacrococcygeal region)
0.052 0.948 0.000
M49.17 Brucella spondylitis (Lumbosacral region)
0.052 0.948 0.000
M49.16 Brucella spondylitis (Lumbar region)
0.052 0.948 0.000
M49.15 Brucella spondylitis (Thoracolumbar region)
0.052 0.948 0.000
M49.14 Brucella spondylitis (Thoracic region)
0.052 0.948 0.000
M49.13 Brucella spondylitis (Cervicothoracic region)
0.052 0.948 0.000
M49.12 Brucella spondylitis (Cervical region)
0.052 0.948 0.000
M49.11 Brucella spondylitis (Occipito-atlanto-axial region)
0.052 0.948 0.000
M49.10 Brucella spondylitis (Multiple sites in spine)
0.052 0.948 0.000
M49.29 Enterobacterial spondylitis (Site unspecified)
0.052 0.948 0.000
M49.28 Enterobacterial spondylitis (Sacral and sacrococcygeal region)
0.052 0.948 0.000
M49.27 Enterobacterial spondylitis (Lumbosacral region)
0.052 0.948 0.000
M49.26 Enterobacterial spondylitis (Lumbar region)
0.052 0.948 0.000
M49.25 Enterobacterial spondylitis (Thoracolumbar region)
0.052 0.948 0.000
M49.24 Enterobacterial spondylitis (Thoracic region)
0.052 0.948 0.000
M49.23 Enterobacterial spondylitis (Cervicothoracic region)
0.052 0.948 0.000
M49.22 Enterobacterial spondylitis (Cervical region)
0.052 0.948 0.000
M49.21 Enterobacterial spondylitis (Occipito-atlanto-axial region)
0.052 0.948 0.000
M49.20 Enterobacterial spondylitis (Multiple sites in spine)
0.052 0.948 0.000
M49.39 Spondylopathy in other infectious and parasitic diseases classified elsewhere (Site unspecified)
0.052 0.948 0.000
M49.38 Spondylopathy in other infectious and parasitic diseases classified elsewhere (Sacral and sacrococcygeal region)
0.052 0.948 0.000
M49.37 Spondylopathy in other infectious and parasitic diseases classified elsewhere (Lumbosacral region)
0.052 0.948 0.000
M49.36 Spondylopathy in other infectious and parasitic diseases classified elsewhere (Lumbar region)
0.052 0.948 0.000
M49.35 Spondylopathy in other infectious and parasitic diseases classified elsewhere (Thoracolumbar region)
0.052 0.948 0.000
M49.34 Spondylopathy in other infectious and parasitic diseases classified elsewhere (Thoracic region)
0.052 0.948 0.000
M49.33 Spondylopathy in other infectious and parasitic diseases classified elsewhere (Cervicothoracic region)
0.052 0.948 0.000
M49.32 Spondylopathy in other infectious and parasitic diseases classified elsewhere (Cervical region)
0.052 0.948 0.000
M49.31 Spondylopathy in other infectious and parasitic diseases classified elsewhere (Occipito-atlanto-axial region)
0.052 0.948 0.000
M49.30 Spondylopathy in other infectious and parasitic diseases classified elsewhere (Multiple sites in spine)
0.052 0.948 0.000
M49.49 Neuropathic spondylopathy (Site unspecified)
0.052 0.948 0.000
M49.48 Neuropathic spondylopathy (Sacral and sacrococcygeal region)
0.052 0.948 0.000
M49.47 Neuropathic spondylopathy (Lumbosacral region)
0.052 0.948 0.000
M49.46 Neuropathic spondylopathy (Lumbar region)
0.052 0.948 0.000
M49.45 Neuropathic spondylopathy (Thoracolumbar region)
0.052 0.948 0.000
M49.44 Neuropathic spondylopathy (Thoracic region)
0.052 0.948 0.000
M49.43 Neuropathic spondylopathy (Cervicothoracic region)
0.052 0.948 0.000
M49.42 Neuropathic spondylopathy (Cervical region)
0.052 0.948 0.000
M49.41 Neuropathic spondylopathy (Occipito-atlanto-axial region)
0.052 0.948 0.000
M49.40 Neuropathic spondylopathy (Multiple sites in spine)
0.052 0.948 0.000
M49.89 Spondylopathy in other diseases classified elsewhere (Site unspecified)
0.052 0.948 0.000
M49.88 Spondylopathy in other diseases classified elsewhere (Sacral and sacrococcygeal region)
0.052 0.948 0.000
M49.87 Spondylopathy in other diseases classified elsewhere (Lumbosacral region)
0.052 0.948 0.000
M49.86 Spondylopathy in other diseases classified elsewhere (Lumbar region)
0.052 0.948 0.000
M49.85 Spondylopathy in other diseases classified elsewhere (Thoracolumbar region)
0.052 0.948 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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