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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs2596531
log Bayes Factor = 89.5215
Chromosome 6   position 31,387,557  (GRCh37) Explore rs2596531 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E03.9 Hypothyroidism, unspecified
0.000 0.000 1.000
K90.0 Coeliac disease
0.000 0.000 1.000
M45.X9 Ankylosing spondylitis (Site unspecified)
1.000 0.000 0.000
R31 Unspecified haematuria
1.000 0.000 0.000
E00-E07 Disorders of thyroid gland
0.000 0.000 1.000
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.000 1.000
L40 Psoriasis
1.000 0.000 0.000
E03 Other hypothyroidism
0.000 0.000 1.000
L40.5 Arthropathic psoriasis
1.000 0.000 0.000
E05.9 Thyrotoxicosis, unspecified
0.000 0.000 1.000
L40.9 Psoriasis, unspecified
1.000 0.000 0.000
E27.1 Primary adrenocortical insufficiency
0.000 0.000 1.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.002 0.998
E27 Other disorders of adrenal gland
0.000 0.002 0.998
E10 Insulin-dependent diabetes mellitus
0.000 0.006 0.994
E10.9 Without complications
0.000 0.006 0.994
E20-E35 Disorders of other endocrine glands
0.000 0.006 0.994
E10-E14 Diabetes mellitus
0.000 0.006 0.994
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.011 0.989
I77.1 Stricture of artery
0.000 0.017 0.983
I77 Other disorders of arteries and arterioles
0.000 0.021 0.979
I70-I79 Diseases of arteries, arterioles and capillaries
0.000 0.028 0.972
I73 Other peripheral vascular diseases
0.000 0.033 0.967
I73.0 Raynaud's syndrome
0.000 0.044 0.956
L40.0 Psoriasis vulgaris
0.950 0.050 0.000
E10.1 With ketoacidosis
0.000 0.052 0.948
M45 Ankylosing spondylitis
0.935 0.065 0.000
E27.2 Addisonian crisis
0.000 0.078 0.922
M45.X0 Ankylosing spondylitis (Multiple sites in spine)
0.919 0.081 0.000
E27.4 Other and unspecified adrenocortical insufficiency
0.000 0.103 0.897
I77.6 Arteritis, unspecified
0.000 0.119 0.881
I73.9 Peripheral vascular disease, unspecified
0.000 0.126 0.874
L40.4 Guttate psoriasis
0.861 0.139 0.000
I74 Arterial embolism and thrombosis
0.000 0.145 0.855
I72 Other aneurysm
0.000 0.167 0.833
L40.8 Other psoriasis
0.831 0.169 0.000
I79 Disorders of arteries, arterioles and capillaries in diseases classified elsewhere
0.000 0.181 0.819
K90 Intestinal malabsorption
0.000 0.188 0.812
E07 Other disorders of thyroid
0.000 0.191 0.809
E20 Hypoparathyroidism
0.000 0.192 0.808
I71 Aortic aneurysm and dissection
0.000 0.196 0.804
D69.6 Thrombocytopenia, unspecified
0.000 0.197 0.803
D69 Purpura and other haemorrhagic conditions
0.000 0.197 0.803
D69.3 Idiopathic thrombocytopenic purpura
0.000 0.203 0.797
I77.8 Other specified disorders of arteries and arterioles
0.000 0.208 0.792
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.217 0.783
I74.8 Embolism and thrombosis of other arteries
0.000 0.225 0.775
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.231 0.769
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.235 0.765
E28 Ovarian dysfunction
0.000 0.242 0.758
E07.8 Other specified disorders of thyroid
0.000 0.244 0.756
K90.9 Intestinal malabsorption, unspecified
0.000 0.245 0.755
E10.0 With coma
0.000 0.245 0.755
I71.3 Abdominal aortic aneurysm, ruptured
0.000 0.245 0.755
E10.2 With renal complications
0.000 0.247 0.753
I73.1 Thromboangiitis obliterans [Buerger]
0.000 0.249 0.751
I72.8 Aneurysm of other specified arteries
0.000 0.262 0.738
L40.1 Generalised pustular psoriasis
0.737 0.262 0.000
E06 Thyroiditis
0.000 0.262 0.737
E50-E64 Other nutritional deficiencies
0.000 0.263 0.737
E10.3 With ophthalmic complications
0.000 0.270 0.730
I74.0 Embolism and thrombosis of abdominal aorta
0.000 0.270 0.730
D69.5 Secondary thrombocytopenia
0.000 0.271 0.729
I79.2 Peripheral angiopathy in diseases classified elsewhere
0.000 0.274 0.726
I77.2 Rupture of artery
0.000 0.275 0.725
E10.7 With multiple complications
0.000 0.282 0.718
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.283 0.717
E00 Congenital iodine-deficiency syndrome
0.000 0.283 0.717
E05.5 Thyroid crisis or storm
0.000 0.283 0.717
E05.4 Thyrotoxicosis factitia
0.000 0.283 0.717
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.283 0.717
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.283 0.717
L40.2 Acrodermatitis continua
0.717 0.283 0.000
E03.5 Myxoedema coma
0.000 0.283 0.717
E03.4 Atrophy of thyroid (acquired)
0.000 0.283 0.717
E03.3 Postinfectious hypothyroidism
0.000 0.283 0.717
I72.3 Aneurysm of iliac artery
0.000 0.284 0.716
E27.5 Adrenomedullary hyperfunction
0.000 0.285 0.715
E27.0 Other adrenocortical overactivity
0.000 0.285 0.715
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.287 0.713
E32 Diseases of thymus
0.000 0.287 0.713
E31 Polyglandular dysfunction
0.000 0.287 0.713
E30 Disorders of puberty, not elsewhere classified
0.000 0.287 0.713
E12 Malnutrition-related diabetes mellitus
0.000 0.288 0.712
E10.6 With other specified complications
0.000 0.288 0.712
L40.3 Pustulosis palmaris et plantaris
0.710 0.290 0.000
E03.8 Other specified hypothyroidism
0.000 0.296 0.704
I77.5 Necrosis of artery
0.000 0.298 0.702
I77.4 Coeliac artery compression syndrome
0.000 0.298 0.702
I77.3 Arterial fibromuscular dysplasia
0.000 0.298 0.702
E53 Deficiency of other B group vitamins
0.000 0.301 0.699
E25 Adrenogenital disorders
0.000 0.302 0.698
M45.X6 Ankylosing spondylitis (Lumbar region)
0.686 0.314 0.000
I74.3 Embolism and thrombosis of arteries of the lower extremities
0.000 0.324 0.676
E20.9 Hypoparathyroidism, unspecified
0.000 0.325 0.675
M45.X8 Ankylosing spondylitis (Sacral and sacrococcygeal region)
0.670 0.330 0.000
M45.X7 Ankylosing spondylitis (Lumbosacral region)
0.670 0.330 0.000
M45.X5 Ankylosing spondylitis (Thoracolumbar region)
0.670 0.330 0.000
M45.X4 Ankylosing spondylitis (Thoracic region)
0.670 0.330 0.000
M45.X3 Ankylosing spondylitis (Cervicothoracic region)
0.670 0.330 0.000
M45.X1 Ankylosing spondylitis (Occipito-atlanto-axial region)
0.670 0.330 0.000
E28.3 Primary ovarian failure
0.000 0.330 0.670
I71.0 Dissection of aorta [any part]
0.000 0.330 0.670
E03.1 Congenital hypothyroidism without goitre
0.000 0.333 0.667
E53.8 Deficiency of other specified B group vitamins
0.000 0.333 0.667
E06.3 Autoimmune thyroiditis
0.000 0.334 0.666
M45.X2 Ankylosing spondylitis (Cervical region)
0.666 0.334 0.000
I71.1 Thoracic aortic aneurysm, ruptured
0.000 0.335 0.665
E34 Other endocrine disorders
0.000 0.337 0.662
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.000 0.340 0.660
L40-L45 Papulosquamous disorders
0.659 0.340 0.000
E40-E46 Malnutrition
0.000 0.346 0.654
D69.4 Other primary thrombocytopenia
0.000 0.360 0.640
J84.9 Interstitial pulmonary disease, unspecified
0.000 0.369 0.631
E22 Hyperfunction of pituitary gland
0.000 0.370 0.630
J84 Other interstitial pulmonary diseases
0.000 0.376 0.624
I74.4 Embolism and thrombosis of arteries of extremities, unspecified
0.000 0.376 0.624
D69.2 Other nonthrombocytopenic purpura
0.000 0.377 0.623
I71.6 Thoracoabdominal aortic aneurysm, without mention of rupture
0.000 0.379 0.621
J84.1 Other interstitial pulmonary diseases with fibrosis
0.000 0.383 0.617
I72.4 Aneurysm of artery of lower extremity
0.000 0.387 0.613
I73.8 Other specified peripheral vascular diseases
0.000 0.389 0.610
I72.9 Aneurysm of unspecified site
0.000 0.391 0.609
E05.8 Other thyrotoxicosis
0.000 0.391 0.608
E10.8 With unspecified complications
0.000 0.392 0.608
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.393 0.606
E10.5 With peripheral circulatory complications
0.000 0.394 0.606
I72.6 Aneurysm and dissection of vertebral artery
0.000 0.402 0.597
E16 Other disorders of pancreatic internal secretion
0.000 0.403 0.597
D69.0 Allergic purpura
0.000 0.405 0.594
I77.9 Disorder of arteries and arterioles, unspecified
0.000 0.409 0.591
I79.1 Aortitis in diseases classified elsewhere
0.000 0.413 0.587
I79.0 Aneurysm of aorta in diseases classified elsewhere
0.000 0.413 0.587
K90.3 Pancreatic steatorrhoea
0.000 0.417 0.582
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.417 0.582
K90.1 Tropical sprue
0.000 0.417 0.582
I72.2 Aneurysm of renal artery
0.000 0.419 0.581
E07.1 Dyshormogenetic goitre
0.000 0.420 0.580
E07.0 Hypersecretion of calcitonin
0.000 0.420 0.580
E20.8 Other hypoparathyroidism
0.000 0.421 0.579
E20.1 Pseudohypoparathyroidism
0.000 0.421 0.579
E20.0 Idiopathic hypoparathyroidism
0.000 0.421 0.579
I71.8 Aortic aneurysm of unspecified site, ruptured
0.000 0.423 0.577
I71.5 Thoracoabdominal aortic aneurysm, ruptured
0.000 0.423 0.577
D69.8 Other specified haemorrhagic conditions
0.000 0.424 0.575
I77.0 Arteriovenous fistula, acquired
0.000 0.425 0.575
I74.5 Embolism and thrombosis of iliac artery
0.000 0.426 0.574
E13 Other specified diabetes mellitus
0.000 0.428 0.572
E27.9 Disorder of adrenal gland, unspecified
0.000 0.430 0.570
K90.8 Other intestinal malabsorption
0.000 0.431 0.569
I74.9 Embolism and thrombosis of unspecified artery
0.000 0.432 0.568
E27.8 Other specified disorders of adrenal gland
0.000 0.437 0.563
E29 Testicular dysfunction
0.000 0.438 0.562
I72.1 Aneurysm of artery of upper extremity
0.000 0.439 0.561
E23 Hypofunction and other disorders of pituitary gland
0.000 0.445 0.555
J84.8 Other specified interstitial pulmonary diseases
0.000 0.451 0.549
E15 Nondiabetic hypoglycaemic coma
0.000 0.452 0.548
I79.8 Other disorders of arteries, arterioles and capillaries in diseases classified elsewhere
0.000 0.453 0.547
E14 Unspecified diabetes mellitus
0.000 0.454 0.546
E34.8 Other specified endocrine disorders
0.000 0.456 0.544
E28.9 Ovarian dysfunction, unspecified
0.000 0.456 0.544
E28.8 Other ovarian dysfunction
0.000 0.456 0.544
E28.1 Androgen excess
0.000 0.456 0.544
E28.0 Oestrogen excess
0.000 0.456 0.544
L43 Lichen planus
0.542 0.458 0.000
I72.5 Aneurysm and dissection of other precerebral arteries
0.000 0.463 0.537
D69.1 Qualitative platelet defects
0.000 0.464 0.536
I74.1 Embolism and thrombosis of other and unspecified parts of aorta
0.000 0.465 0.535
E06.4 Drug-induced thyroiditis
0.000 0.471 0.529
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.471 0.529
E06.0 Acute thyroiditis
0.000 0.471 0.529
E27.3 Drug-induced adrenocortical insufficiency
0.000 0.471 0.528
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.471 0.528
E63 Other nutritional deficiencies
0.000 0.471 0.528
E50 Vitamin A deficiency
0.000 0.471 0.528
E60 Dietary zinc deficiency
0.000 0.471 0.528
E59 Dietary selenium deficiency
0.000 0.471 0.528
E52 Niacin deficiency [pellagra]
0.000 0.471 0.528
D69.9 Haemorrhagic condition, unspecified
0.000 0.474 0.526
L42 Pityriasis rosea
0.526 0.474 0.000
E53.9 Vitamin B deficiency, unspecified
0.000 0.474 0.526
L41 Parapsoriasis
0.525 0.474 0.000
E10.4 With neurological complications
0.000 0.482 0.518
E56 Other vitamin deficiencies
0.000 0.483 0.517
I71.4 Abdominal aortic aneurysm, without mention of rupture
0.000 0.486 0.514
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.000 0.486 0.514
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.000 0.486 0.514
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.000 0.486 0.514
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.000 0.486 0.514
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.486 0.514
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.000 0.486 0.514
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.000 0.486 0.514
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.000 0.486 0.514
E34.9 Endocrine disorder, unspecified
0.000 0.486 0.514
E51 Thiamine deficiency
0.000 0.486 0.514
E30.9 Disorder of puberty, unspecified
0.000 0.489 0.511
E30.8 Other disorders of puberty
0.000 0.489 0.511
E30.1 Precocious puberty
0.000 0.489 0.511
E30.0 Delayed puberty
0.000 0.489 0.511
E31.9 Polyglandular dysfunction, unspecified
0.000 0.489 0.511
E31.8 Other polyglandular dysfunction
0.000 0.489 0.511
E31.1 Polyglandular hyperfunction
0.000 0.489 0.511
E31.0 Autoimmune polyglandular failure
0.000 0.489 0.511
E32.9 Disease of thymus, unspecified
0.000 0.489 0.511
E32.8 Other diseases of thymus
0.000 0.489 0.511
E32.1 Abscess of thymus
0.000 0.489 0.511
E32.0 Persistent hyperplasia of thymus
0.000 0.489 0.511
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.489 0.511
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.489 0.511
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.489 0.511
E12.9 Without complications
0.000 0.489 0.511
E12.8 With unspecified complications
0.000 0.489 0.511
E12.7 With multiple complications
0.000 0.489 0.511
E12.6 With other specified complications
0.000 0.489 0.511
E12.5 With peripheral circulatory complications
0.000 0.489 0.511
E12.4 With neurological complications
0.000 0.489 0.511
E12.3 With ophthalmic complications
0.000 0.489 0.511
E12.2 With renal complications
0.000 0.489 0.511
E12.1 With ketoacidosis
0.000 0.489 0.511
E12.0 With coma
0.000 0.489 0.511
E16.2 Hypoglycaemia, unspecified
0.000 0.490 0.510
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.491 0.508
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions
0.000 0.498 0.502
E53.1 Pyridoxine deficiency
0.000 0.499 0.501
E53.0 Riboflavin deficiency
0.000 0.499 0.501
E25.9 Adrenogenital disorder, unspecified
0.000 0.499 0.501
E25.8 Other adrenogenital disorders
0.000 0.499 0.501
I70 Atherosclerosis
0.000 0.502 0.498
E54 Ascorbic acid deficiency
0.000 0.507 0.493
E23.2 Diabetes insipidus
0.000 0.508 0.492
E06.5 Other chronic thyroiditis
0.000 0.512 0.488
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.000 0.514 0.486
E34.5 Androgen resistance syndrome
0.000 0.525 0.475
E34.4 Constitutional tall stature
0.000 0.525 0.475
E34.2 Ectopic hormone secretion, not elsewhere classified
0.000 0.525 0.475
E34.1 Other hypersecretion of intestinal hormones
0.000 0.525 0.475
I72.0 Aneurysm of carotid artery
0.000 0.526 0.474
L45 Papulosquamous disorders in diseases classified elsewhere
0.473 0.527 0.000
E06.9 Thyroiditis, unspecified
0.000 0.531 0.469
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.531 0.469
E45 Retarded development following protein-energy malnutrition
0.000 0.531 0.469
E43 Unspecified severe protein-energy malnutrition
0.000 0.531 0.469
E42 Marasmic kwashiorkor
0.000 0.531 0.469
E41 Nutritional marasmus
0.000 0.531 0.469
E40 Kwashiorkor
0.000 0.531 0.469
I74.2 Embolism and thrombosis of arteries of the upper extremities
0.000 0.531 0.469
E26 Hyperaldosteronism
0.001 0.540 0.459
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.000 0.548 0.452
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.548 0.452
E22.8 Other hyperfunction of pituitary gland
0.000 0.548 0.452
L44 Other papulosquamous disorders
0.445 0.555 0.000
E34.3 Short stature, not elsewhere classified
0.000 0.556 0.444
E22.1 Hyperprolactinaemia
0.000 0.556 0.444
E58 Dietary calcium deficiency
0.000 0.558 0.442
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.000 0.563 0.437
L41.1 Pityriasis lichenoides chronica
0.429 0.571 0.000
L43.8 Other lichen planus
0.428 0.571 0.000
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.571 0.428
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.571 0.428
E16.4 Abnormal secretion of gastrin
0.000 0.571 0.428
E16.3 Increased secretion of glucagon
0.000 0.571 0.428
D80-D89 Certain disorders involving the immune mechanism
0.000 0.576 0.424
E14.5 With peripheral circulatory complications
0.000 0.578 0.422
L43.9 Lichen planus, unspecified
0.422 0.578 0.000
E14.2 Withrenal complications
0.000 0.580 0.420
E55 Vitamin D deficiency
0.000 0.581 0.419
J84.0 Alveolar and parietoalveolar conditions
0.000 0.583 0.417
E29.9 Testicular dysfunction, unspecified
0.000 0.587 0.413
E16.1 Other hypoglycaemia
0.000 0.589 0.411
E13.8 With unspecified complications
0.000 0.590 0.410
E13.7 With multiple complications
0.000 0.590 0.410
E13.6 With other specified complications
0.000 0.590 0.410
E13.5 With peripheral circulatory complications
0.000 0.590 0.410
E13.4 With neurological complications
0.000 0.590 0.410
E13.2 With renal complications
0.000 0.590 0.410
E13.1 With ketoacidosis
0.000 0.590 0.410
E13.0 With coma
0.000 0.590 0.410
E46 Unspecified protein-energy malnutrition
0.000 0.593 0.407
E29.8 Other testicular dysfunction
0.000 0.597 0.403
E29.0 Testicular hyperfunction
0.000 0.597 0.403
D50-D53 Nutritional anaemias
0.000 0.598 0.402
E14.6 With other specified complications
0.000 0.598 0.402
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.000 0.602 0.398
E23.1 Drug-induced hypopituitarism
0.000 0.602 0.398
D86.9 Sarcoidosis, unspecified
0.000 0.603 0.397
L43.0 Hypertrophic lichen planus
0.397 0.603 0.000
D86 Sarcoidosis
0.000 0.604 0.396
E14.7 With multiple complications
0.000 0.608 0.392
E14.0 With coma
0.000 0.608 0.392
D55-D59 Haemolytic anaemias
0.000 0.609 0.391
L43.3 Subacute (active) lichen planus
0.389 0.611 0.000
L43.2 Lichenoid drug reaction
0.389 0.611 0.000
L43.1 Bullous lichen planus
0.389 0.611 0.000
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.611 0.388
E61 Deficiency of other nutrient elements
0.000 0.616 0.384
E13.3 With ophthalmic complications
0.000 0.618 0.381
I70.9 Generalised and unspecified atherosclerosis
0.000 0.619 0.381
E06.1 Subacute thyroiditis
0.001 0.620 0.380
E14.3 With ophthalmic complications
0.000 0.620 0.380
E50.9 Vitamin A deficiency, unspecified
0.000 0.621 0.379
E50.8 Other manifestations of vitamin A deficiency
0.000 0.621 0.379
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.621 0.379
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.621 0.379
E50.5 Vitamin A deficiency with night blindness
0.000 0.621 0.379
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.621 0.379
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.621 0.379
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.621 0.379
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.621 0.379
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.621 0.379
E63.9 Nutritional deficiency, unspecified
0.000 0.621 0.379
E63.8 Other specified nutritional deficiencies
0.000 0.621 0.379
E63.1 Imbalance of constituents of food intake
0.000 0.621 0.379
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.621 0.379
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.621 0.379
E64.8 Sequelae of other nutritional deficiencies
0.000 0.621 0.379
E64.3 Sequelae of rickets
0.000 0.621 0.379
E64.2 Sequelae of vitamin C deficiency
0.000 0.621 0.379
E64.1 Sequelae of vitamin A deficiency
0.000 0.621 0.379
E64.0 Sequelae of protein-energy malnutrition
0.000 0.621 0.379
E22.0 Acromegaly and pituitary gigantism
0.000 0.621 0.379
D50 Iron deficiency anaemia
0.000 0.621 0.379
J80-J84 Other respiratory diseases principally affecting the interstitium
0.000 0.622 0.378
I78 Diseases of capillaries
0.000 0.623 0.377
L41.9 Parapsoriasis, unspecified
0.377 0.623 0.000
L41.8 Other parapsoriasis
0.377 0.623 0.000
L41.5 Retiform parapsoriasis
0.377 0.623 0.000
L41.4 Large plaque parapsoriasis
0.377 0.623 0.000
L41.3 Small plaque parapsoriasis
0.377 0.623 0.000
L41.2 Lymphomatoid papulosis
0.377 0.623 0.000
L41.0 Pityriasis lichenoides et varioliformis acuta
0.377 0.623 0.000
E23.6 Other disorders of pituitary gland
0.000 0.624 0.375
D59 Acquired haemolytic anaemia
0.000 0.628 0.372
E56.9 Vitamin deficiency, unspecified
0.000 0.629 0.371
E56.8 Deficiency of other vitamins
0.000 0.629 0.371
E56.0 Deficiency of vitamin E
0.000 0.629 0.371
E14.1 With ketoacidosis
0.000 0.630 0.370
E51.9 Thiamine deficiency, unspecified
0.000 0.631 0.368
E51.8 Other manifestations of thiamine deficiency
0.000 0.631 0.368
E51.1 Beriberi
0.000 0.631 0.368
D80 Immunodeficiency with predominantly antibody defects
0.000 0.636 0.363
E56.1 Deficiency of vitamin K
0.000 0.641 0.359
E51.2 Wernicke's encephalopathy
0.000 0.646 0.354
J33.0 Polyp of nasal cavity
0.000 0.647 0.353
D59.1 Other autoimmune haemolytic anaemias
0.000 0.648 0.352
E24 Cushing's syndrome
0.001 0.650 0.349
I70.1 Atherosclerosis of renal artery
0.000 0.650 0.350
I70.8 Atherosclerosis of other arteries
0.000 0.651 0.349
E28.2 Polycystic ovarian syndrome
0.000 0.652 0.348
D68 Other coagulation defects
0.000 0.653 0.347
E14.4 With neurological complications
0.000 0.654 0.346
D50.9 Iron deficiency anaemia, unspecified
0.000 0.656 0.344
E44.1 Mild protein-energy malnutrition
0.000 0.664 0.336
E44.0 Moderate protein-energy malnutrition
0.000 0.664 0.336
E26.8 Other hyperaldosteronism
0.001 0.670 0.329
E26.1 Secondary hyperaldosteronism
0.001 0.670 0.329
D68.3 Haemorrhagic disorder due to circulating anticoagulants
0.000 0.670 0.330
D83 Common variable immunodeficiency
0.000 0.670 0.330
E14.8 With unspecified complications
0.000 0.677 0.323
D89 Other disorders involving the immune mechanism, not elsewhere classified
0.000 0.679 0.321
D52 Folate deficiency anaemia
0.000 0.680 0.320
E14.9 Without complications
0.000 0.680 0.320
L44.9 Papulosquamous disorder, unspecified
0.319 0.681 0.000
L44.8 Other specified papulosquamous disorders
0.319 0.681 0.000
L44.4 Infantile papular acrodermatitis [Giannotti-Crosti]
0.319 0.681 0.000
L44.3 Lichen ruber moniliformis
0.319 0.681 0.000
L44.2 Lichen striatus
0.319 0.681 0.000
L44.1 Lichen nitidus
0.319 0.681 0.000
D84 Other immunodeficiencies
0.000 0.685 0.315
E13.9 Without complications
0.000 0.685 0.315
D50.0 Iron deficiency anaemia secondary to blood loss (chronic)
0.000 0.687 0.313
D66 Hereditary factor VIII deficiency
0.000 0.688 0.311
J81 Pulmonary oedema
0.000 0.690 0.310
D80.2 Selective deficiency of immunoglobulin A [IgA]
0.000 0.692 0.308
E23.7 Disorder of pituitary gland, unspecified
0.000 0.693 0.307
D59.9 Acquired haemolytic anaemia, unspecified
0.000 0.694 0.306
D81 Combined immunodeficiencies
0.000 0.696 0.304
D65 Disseminated intravascular coagulation [defibrination syndrome]
0.000 0.696 0.304
D80.1 Nonfamilial hypogammaglobulinaemia
0.000 0.697 0.303
D53 Other nutritional anaemias
0.000 0.697 0.303
E55.0 Rickets, active
0.000 0.699 0.301
J82 Pulmonary eosinophilia, not elsewhere classified
0.000 0.699 0.301
I70.90 Generalized and unspecified atherosclerosis (without gangrene)
0.000 0.702 0.297
D50.8 Other iron deficiency anaemias
0.000 0.707 0.293
L44.0 Pityriasis rubra pilaris
0.291 0.709 0.000
D82 Immunodeficiency associated with other major defects
0.000 0.709 0.290
E65-E68 Obesity and other hyperalimentation
0.000 0.710 0.290
I70.0 Atherosclerosis of aorta
0.000 0.710 0.290
I78.9 Disease of capillaries, unspecified
0.000 0.714 0.286
D86.2 Sarcoidosis of lung with sarcoidosis of lymph nodes
0.000 0.715 0.285
D80.4 Selective deficiency of immunoglobulin M [IgM]
0.000 0.716 0.284
E26.9 Hyperaldosteronism, unspecified
0.001 0.718 0.281
D55 Anaemia due to enzyme disorders
0.000 0.719 0.281
E04 Other non-toxic goitre
0.000 0.722 0.278
D67 Hereditary factor IX deficiency
0.000 0.723 0.277
E61.9 Deficiency of nutrient element, unspecified
0.000 0.725 0.275
E61.8 Deficiency of other specified nutrient elements
0.000 0.725 0.275
E61.7 Deficiency of multiple nutrient elements
0.000 0.725 0.275
E61.6 Vanadium deficiency
0.000 0.725 0.275
E61.5 Molybdenum deficiency
0.000 0.725 0.275
E61.4 Chromium deficiency
0.000 0.725 0.275
E61.3 Manganese deficiency
0.000 0.725 0.275
E61.0 Copper deficiency
0.000 0.725 0.275
I71.9 Aortic aneurysm of unspecified site, without mention of rupture
0.000 0.725 0.275
I70.91 Generalized and unspecified atherosclerosis (with gangrene)
0.000 0.727 0.273
D86.1 Sarcoidosis of lymph nodes
0.000 0.727 0.273
D50.1 Sideropenic dysphagia
0.000 0.728 0.272
E61.2 Magnesium deficiency
0.000 0.730 0.269
J80 Adult respiratory distress syndrome
0.000 0.732 0.268
D59.8 Other acquired haemolytic anaemias
0.000 0.733 0.267
D59.6 Haemoglobinuria due to haemolysis from other external causes
0.000 0.733 0.267
D59.5 Paroxysmal nocturnal haemoglobinuria [Marchiafava-Micheli]
0.000 0.733 0.267
D59.3 Haemolytic-uraemic syndrome
0.000 0.733 0.267
D59.2 Drug-induced nonautoimmune haemolytic anaemia
0.000 0.733 0.267
D57 Sickle-cell disorders
0.000 0.734 0.266
D58 Other hereditary haemolytic anaemias
0.000 0.734 0.266
D59.4 Other nonautoimmune haemolytic anaemias
0.000 0.738 0.262
D83.9 Common variable immunodeficiency, unspecified
0.000 0.738 0.262
D89.9 Disorder involving the immune mechanism, unspecified
0.000 0.738 0.262
D59.0 Drug-induced autoimmune haemolytic anaemia
0.000 0.739 0.261
D80.8 Other immunodeficiencies with predominantly antibody defects
0.000 0.739 0.261
D80.7 Transient hypogammaglobulinaemia of infancy
0.000 0.739 0.261
D80.6 Antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinaemia
0.000 0.739 0.261
D80.5 Immunodeficiency with increased immunoglobulin M [IgM]
0.000 0.739 0.261
D80.0 Hereditary hypogammaglobulinaemia
0.000 0.739 0.261
D52.9 Folate deficiency anaemia, unspecified
0.000 0.739 0.260
I78.8 Other diseases of capillaries
0.000 0.740 0.259
D86.3 Sarcoidosis of skin
0.000 0.744 0.256
D68.5 Primary Thrombophilia
0.000 0.744 0.256
E34.0 Carcinoid syndrome
0.001 0.744 0.255
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.001 0.749 0.250
E24.3 Ectopic ACTH syndrome
0.001 0.749 0.250
E24.1 Nelson's syndrome
0.001 0.749 0.250
I70.11 Atherosclerosis of renal artery (with gangrene)
0.000 0.749 0.251
I70.81 Atherosclerosis of other arteries (with gangrene)
0.000 0.749 0.250
D56 Thalassaemia
0.000 0.751 0.249
D68.9 Coagulation defect, unspecified
0.000 0.753 0.247
I70.2 Atherosclerosis of arteries of the extremities
0.000 0.754 0.246
D89.8 Other specified disorders involving the immune mechanism, not elsewhere classified
0.000 0.755 0.245
I70.10 Atherosclerosis of renal artery (without gangrene)
0.000 0.756 0.244
I70.80 Atherosclerosis of other arteries (without gangrene)
0.000 0.757 0.243
E24.8 Other Cushing's syndrome
0.001 0.763 0.236
D83.8 Other common variable immunodeficiencies
0.000 0.763 0.236
D83.2 Common variable immunodeficiency with autoantibodies to B- or T-cells
0.000 0.763 0.236
D83.1 Common variable immunodeficiency with predominant immunoregulatory T-cell disorders
0.000 0.763 0.236
D83.0 Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function
0.000 0.763 0.236
E24.2 Drug-induced Cushing's syndrome
0.001 0.763 0.236
D84.1 Defects in the complement system
0.000 0.764 0.236
D68.1 Hereditary factor XI deficiency
0.000 0.764 0.236
D84.9 Immunodeficiency, unspecified
0.000 0.766 0.233
E29.1 Testicular hypofunction
0.000 0.768 0.232
D53.9 Nutritional anaemia, unspecified
0.000 0.769 0.231
D80.9 Immunodeficiency with predominantly antibody defects, unspecified
0.000 0.769 0.231
D68.4 Acquired coagulation factor deficiency
0.000 0.769 0.231
D89.3 Immune reconstitution syndrome
0.000 0.769 0.231
D89.0 Polyclonal hypergammaglobulinaemia
0.000 0.770 0.229
D52.8 Other folate deficiency anaemias
0.000 0.771 0.229
D52.1 Drug-induced folate deficiency anaemia
0.000 0.771 0.229
D52.0 Dietary folate deficiency anaemia
0.000 0.771 0.229
D89.2 Hypergammaglobulinaemia, unspecified
0.000 0.771 0.229
D80.3 Selective deficiency of immunoglobulin G [IgG] subclasses
0.000 0.772 0.228
E04.0 Non-toxic diffuse goitre
0.000 0.773 0.227
D84.0 Lymphocyte function antigen-1 [LFA-1] defect
0.000 0.774 0.226
D68.2 Hereditary deficiency of other clotting factors
0.000 0.776 0.224
D58.0 Hereditary spherocytosis
0.000 0.777 0.223
D84.8 Other specified immunodeficiencies
0.000 0.780 0.220
D81.9 Combined immunodeficiency, unspecified
0.000 0.782 0.218
D81.8 Other combined immunodeficiencies
0.000 0.782 0.218
D81.7 Major histocompatibility complex class II deficiency
0.000 0.782 0.218
D81.6 Major histocompatibility complex class I deficiency
0.000 0.782 0.218
D81.5 Purine nucleoside phosphorylase [PNP] deficiency
0.000 0.782 0.218
D81.4 Nezelof's syndrome
0.000 0.782 0.218
D81.3 Adenosine deaminase [ADA] deficiency
0.000 0.782 0.218
D81.2 Severe combined immunodeficiency [SCID] with low or normal B-cell numbers
0.000 0.782 0.218
D81.1 Severe combined immunodeficiency [SCID] with low T- and B-cell numbers
0.000 0.782 0.218
D81.0 Severe combined immunodeficiency [SCID] with reticular dysgenesis
0.000 0.782 0.218
D51 Vitamin B12 deficiency anaemia
0.000 0.782 0.218
D53.8 Other specified nutritional anaemias
0.000 0.783 0.217
D53.2 Scorbutic anaemia
0.000 0.783 0.217
D53.1 Other megaloblastic anaemias, not elsewhere classified
0.000 0.783 0.217
D53.0 Protein deficiency anaemia
0.000 0.783 0.217
D68.6 Other Thrombophilia
0.000 0.784 0.216
E07.9 Disorder of thyroid, unspecified
0.000 0.785 0.214
D68.0 Von Willebrand's disease
0.000 0.789 0.211
I78.0 Hereditary haemorrhagic telangiectasia
0.000 0.791 0.209
D82.9 Immunodeficiency associated with major defect, unspecified
0.000 0.791 0.208
D82.8 Immunodeficiency associated with other specified major defects
0.000 0.791 0.208
D82.4 Hyperimmunoglobulin E [IgE] syndrome
0.000 0.791 0.208
D82.3 Immunodeficiency following hereditary defective response to Epstein-Barr virus
0.000 0.791 0.208
D82.2 Immunodeficiency with short-limbed stature
0.000 0.791 0.208
D82.0 Wiskott-Aldrich syndrome
0.000 0.791 0.208
E67 Other hyperalimentation
0.000 0.792 0.208
E68 Sequelae of hyperalimentation
0.000 0.792 0.208
I70.01 Atherosclerosis of aorta (with gangrene)
0.000 0.792 0.208
D55.9 Anaemia due to enzyme disorder, unspecified
0.000 0.799 0.201
D55.8 Other anaemias due to enzyme disorders
0.000 0.799 0.201
D55.3 Anaemia due to disorders of nucleotide metabolism
0.000 0.799 0.201
D55.2 Anaemia due to disorders of glycolytic enzymes
0.000 0.799 0.201
D55.1 Anaemia due to other disorders of glutathione metabolism
0.000 0.799 0.201
D55.0 Anaemia due to glucose-6-phosphate dehydrogenase [G6PD] deficiency
0.000 0.799 0.201
E04.8 Other specified non-toxic goitre
0.000 0.800 0.200

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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