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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs2596573
log Bayes Factor = 68.1198
Chromosome 6   position 31,347,930  (GRCh37) Explore rs2596573 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E03.9 Hypothyroidism, unspecified
0.000 0.000 1.000
E10.9 Without complications
0.000 0.000 1.000
M06.9 Rheumatoid arthritis, unspecified
0.000 0.000 1.000
M45.X9 Ankylosing spondylitis (Site unspecified)
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
E10-E14 Diabetes mellitus
0.000 0.000 1.000
E00-E07 Disorders of thyroid gland
0.000 0.000 1.000
I20-I25 Ischaemic heart diseases
0.000 0.000 1.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.000 1.000
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)
0.000 0.000 1.000
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)
0.000 0.000 1.000
E10.3 With ophthalmic complications
0.000 0.000 1.000
E78.0 Pure hypercholesterolaemia
0.000 0.000 1.000
I25 Chronic ischaemic heart disease
0.000 0.000 1.000
E83.1 Disorders of iron metabolism
1.000 0.000 0.000
E03 Other hypothyroidism
0.000 0.000 1.000
M45 Ankylosing spondylitis
0.000 0.000 1.000
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.000 0.000 1.000
I25.1 Atherosclerotic heart disease
0.000 0.000 1.000
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.000 1.000
M06 Other rheumatoid arthritis
0.000 0.000 1.000
Chapter IX Diseases of the circulatory system
0.000 0.000 1.000
E14 Unspecified diabetes mellitus
0.000 0.001 0.999
E11 Non-insulin-dependent diabetes mellitus
0.000 0.001 0.999
I10-I15 Hypertensive diseases
0.000 0.001 0.999
M05-M14 Inflammatory polyarthropathies
0.000 0.001 0.999
G35 Multiple sclerosis
0.999 0.001 0.000
E14.9 Without complications
0.000 0.001 0.999
E70-E90 Metabolic disorders
0.000 0.002 0.998
E11.9 Without complications
0.000 0.002 0.998
I10 Essential (primary) hypertension
0.000 0.002 0.998
E05.9 Thyrotoxicosis, unspecified
0.000 0.002 0.998
Chapter XIII Diseases of the musculoskeletal system and connective tissue
0.000 0.003 0.997
M45-M49 Spondylopathies
0.000 0.003 0.997
E10.1 With ketoacidosis
0.000 0.004 0.996
L40 Psoriasis
0.000 0.005 0.995
L40.5 Arthropathic psoriasis
0.000 0.006 0.994
# Top node
0.000 0.006 0.994
I21 Acute myocardial infarction
0.000 0.006 0.994
I22 Subsequent myocardial infarction
0.000 0.008 0.992
L40-L45 Papulosquamous disorders
0.000 0.011 0.989
L40.9 Psoriasis, unspecified
0.000 0.012 0.988
I21.9 Acute myocardial infarction, unspecified
0.000 0.014 0.986
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.014 0.986
I22.1 Subsequent myocardial infarction of inferior wall
0.000 0.020 0.980
Chapter XII Diseases of the skin and subcutaneous tissue
0.000 0.022 0.978
M07 Psoriatic and enteropathic arthropathies
0.000 0.027 0.973
I25.5 Ischaemic cardiomyopathy
0.000 0.028 0.972
E20-E35 Disorders of other endocrine glands
0.000 0.029 0.971
I12 Hypertensive renal disease
0.000 0.032 0.968
M45.X0 Ankylosing spondylitis (Multiple sites in spine)
0.000 0.038 0.962
E10.4 With neurological complications
0.000 0.042 0.958
M07.3 Other psoriatic arthropathies
0.000 0.043 0.957
M06.96 Rheumatoid arthritis, unspecified (Lower leg)
0.000 0.043 0.957
I21.2 Acute transmural myocardial infarction of other sites
0.000 0.045 0.955
I12.9 Hypertensive renal disease without renal failure
0.000 0.053 0.946
M06.94 Rheumatoid arthritis, unspecified (Hand)
0.000 0.058 0.942
M05 Seropositive rheumatoid arthritis
0.000 0.060 0.940
M45.X2 Ankylosing spondylitis (Cervical region)
0.000 0.066 0.934
M07.30 Other psoriatic arthropathies (Multiple sites)
0.000 0.066 0.934
I25.8 Other forms of chronic ischaemic heart disease
0.000 0.066 0.934
M06.91 Rheumatoid arthritis, unspecified (Shoulder region)
0.000 0.076 0.924
M06.3 Rheumatoid nodule
0.000 0.078 0.922
I24 Other acute ischaemic heart diseases
0.000 0.083 0.917
Chapter V Mental and behavioural disorders
0.000 0.083 0.917
F30-F39 Mood [affective] disorders
0.000 0.083 0.917
F31 Bipolar affective disorder
0.000 0.087 0.913
M05.9 Seropositive rheumatoid arthritis, unspecified
0.000 0.090 0.910
E11.1 With ketoacidosis
0.000 0.090 0.910
E78.2 Mixed hyperlipidaemia
0.000 0.097 0.903
Chapter VIII Diseases of the ear and mastoid process
0.000 0.100 0.900
I70-I79 Diseases of arteries, arterioles and capillaries
0.000 0.102 0.898
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.000 0.102 0.898
L43 Lichen planus
0.000 0.103 0.897
M06.93 Rheumatoid arthritis, unspecified (Forearm)
0.000 0.105 0.895
E06 Thyroiditis
0.000 0.110 0.890
E10.2 With renal complications
0.000 0.110 0.890
F30 Manic episode
0.000 0.111 0.889
M06.97 Rheumatoid arthritis, unspecified (Ankle and foot)
0.000 0.115 0.885
H60-H62 Diseases of external ear
0.000 0.117 0.883
I70 Atherosclerosis
0.000 0.121 0.879
M70-M79 Other soft tissue disorders
0.000 0.124 0.876
E28 Ovarian dysfunction
0.000 0.126 0.874
M07.36 Other psoriatic arthropathies (Lower leg)
0.000 0.130 0.870
I70.2 Atherosclerosis of arteries of the extremities
0.000 0.132 0.868
E07 Other disorders of thyroid
0.000 0.132 0.868
E78.1 Pure hyperglyceridaemia
0.000 0.134 0.866
I24.8 Other forms of acute ischaemic heart disease
0.000 0.134 0.866
M70 Soft tissue disorders related to use, overuse and pressure
0.000 0.142 0.858
H60 Otitis externa
0.000 0.143 0.857
I70.20 Atherosclerosis of arteries of extremities (without gangrene)
0.000 0.145 0.855
M05.99 Seropositive rheumatoid arthritis, unspecified (Site unspecified)
0.000 0.146 0.854
E23 Hypofunction and other disorders of pituitary gland
0.000 0.147 0.853
I15 Secondary hypertension
0.000 0.151 0.849
M70.4 Prepatellar bursitis
0.000 0.153 0.847
E27 Other disorders of adrenal gland
0.000 0.156 0.844
I20 Angina pectoris
0.000 0.156 0.844
L40.8 Other psoriasis
0.000 0.159 0.841
M70.46 Prepatellar bursitis-Lower Leg
0.000 0.160 0.840
M35 Other systemic involvement of connective tissue
0.000 0.161 0.839
M05.90 Seropositive rheumatoid arthritis, unspecified (Multiple sites)
0.000 0.162 0.838
M20-M25 Other joint disorders
0.000 0.163 0.837
F30.0 Hypomania
0.000 0.164 0.836
M06.92 Rheumatoid arthritis, unspecified (Upper arm)
0.000 0.168 0.832
E10.8 With unspecified complications
0.000 0.169 0.831
E78.8 Other disorders of lipoprotein metabolism
0.000 0.169 0.831
M35.3 Polymyalgia rheumatica
0.000 0.170 0.830
M75 Shoulder lesions
0.000 0.176 0.824
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.178 0.822
E11.0 With coma
0.000 0.180 0.820
F31.1 Bipolar affective disorder, current episode manic without psychotic symptoms
0.000 0.180 0.820
I22.8 Subsequent myocardial infarction of other sites
0.000 0.180 0.820
I22.9 Subsequent myocardial infarction of unspecified site
0.000 0.181 0.819
I23 Certain current complications following acute myocardial infarction
0.000 0.181 0.819
E11.3 With ophthalmic complications
0.000 0.181 0.819
I05-I09 Chronic rheumatic heart diseases
0.000 0.183 0.817
E10.5 With peripheral circulatory complications
0.000 0.184 0.816
F31.3 Bipolar affective disorder, current episode mild or moderate depression
0.000 0.185 0.815
F31.0 Bipolar affective disorder, current episode hypomanic
0.000 0.186 0.814
E78.6 Lipoprotein deficiency
0.000 0.186 0.814
E06.3 Autoimmune thyroiditis
0.000 0.188 0.812
E11.5 With peripheral circulatory complications
0.000 0.190 0.810
M75.0 Adhesive capsulitis of shoulder
0.000 0.193 0.807
E74 Other disorders of carbohydrate metabolism
0.000 0.193 0.807
E14.3 With ophthalmic complications
0.000 0.193 0.807
I20.0 Unstable angina
0.000 0.195 0.805
F80-F89 Disorders of psychological development
0.000 0.200 0.800
E22 Hyperfunction of pituitary gland
0.000 0.201 0.799
M06.32 Rheumatoid nodule (Upper arm)
0.000 0.208 0.792
E14.1 With ketoacidosis
0.000 0.208 0.792
H60.9 Otitis externa, unspecified
0.000 0.216 0.784
I21.4 Acute subendocardial myocardial infarction
0.000 0.216 0.784
E78.4 Other hyperlipidaemia
0.000 0.216 0.784
K90.0 Coeliac disease
0.000 0.222 0.778
L40.1 Generalised pustular psoriasis
0.000 0.222 0.778
E28.2 Polycystic ovarian syndrome
0.000 0.223 0.777
E23.7 Disorder of pituitary gland, unspecified
0.000 0.223 0.777
E78.9 Disorder of lipoprotein metabolism, unspecified
0.000 0.223 0.777
L43.9 Lichen planus, unspecified
0.000 0.228 0.772
E10.0 With coma
0.000 0.229 0.771
E85 Amyloidosis
0.000 0.229 0.771
M34 Systemic sclerosis
0.000 0.229 0.771
M06.98 Rheumatoid arthritis, unspecified (Other)
0.000 0.230 0.770
E27.1 Primary adrenocortical insufficiency
0.000 0.230 0.770
F30.9 Manic episode, unspecified
0.000 0.231 0.769
I08 Multiple valve diseases
0.000 0.231 0.769
E14.4 With neurological complications
0.000 0.232 0.768
M06.34 Rheumatoid nodule (Hand)
0.000 0.232 0.768
E11.2 With renal complications
0.000 0.233 0.767
I79 Disorders of arteries, arterioles and capillaries in diseases classified elsewhere
0.000 0.234 0.766
F31.9 Bipolar affective disorder, unspecified
0.000 0.235 0.765
F31.5 Bipolar affective disorder, current episode severe depression with psychotic symptoms
0.000 0.237 0.763
L43.8 Other lichen planus
0.000 0.238 0.762
I25.2 Old myocardial infarction
0.000 0.239 0.761
F31.6 Bipolar affective disorder, current episode mixed
0.000 0.242 0.758
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.000 0.242 0.758
E07.9 Disorder of thyroid, unspecified
0.000 0.243 0.757
H61 Other disorders of external ear
0.000 0.245 0.755
M49 Spondylopathies in diseases classified elsewhere
0.000 0.245 0.755
E14.5 With peripheral circulatory complications
0.000 0.253 0.747
M35.1 Other overlap syndromes
0.000 0.254 0.746
G35-G37 Demyelinating diseases of the central nervous system
0.745 0.255 0.000
I73 Other peripheral vascular diseases
0.000 0.256 0.744
H60.3 Other infective otitis externa
0.000 0.263 0.737
M07.37 Other psoriatic arthropathies (Ankle and foot)
0.000 0.267 0.733
M06.37 Rheumatoid nodule (Ankle and foot)
0.000 0.267 0.733
E73 Lactose intolerance
0.000 0.268 0.732
I15.9 Seconday hypertension, unspecified
0.000 0.270 0.730
E79 Disorders of purine and pyrimidine metabolism
0.000 0.270 0.730
M75.4 Impingement syndrome of shoulder
0.000 0.273 0.727
E27.9 Disorder of adrenal gland, unspecified
0.000 0.274 0.726
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.000 0.279 0.721
E84 Cystic fibrosis
0.000 0.280 0.720
I70.21 Atherosclerosis of arteries of extremities (with gangrene)
0.000 0.281 0.719
I08.1 Disorders of both mitral and tricuspid valves
0.000 0.282 0.718
E29 Testicular dysfunction
0.000 0.282 0.718
I74 Arterial embolism and thrombosis
0.000 0.283 0.717
E10.7 With multiple complications
0.000 0.283 0.717
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.283 0.717
E00 Congenital iodine-deficiency syndrome
0.000 0.283 0.717
E12 Malnutrition-related diabetes mellitus
0.000 0.283 0.717
I25.6 Silent myocardial ischaemia
0.000 0.283 0.717
E03.5 Myxoedema coma
0.000 0.283 0.717
E03.4 Atrophy of thyroid (acquired)
0.000 0.283 0.717
E03.3 Postinfectious hypothyroidism
0.000 0.283 0.717
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.283 0.717
M45.X8 Ankylosing spondylitis (Sacral and sacrococcygeal region)
0.000 0.283 0.717
M45.X7 Ankylosing spondylitis (Lumbosacral region)
0.000 0.283 0.717
M45.X6 Ankylosing spondylitis (Lumbar region)
0.000 0.283 0.717
M45.X5 Ankylosing spondylitis (Thoracolumbar region)
0.000 0.283 0.717
M45.X4 Ankylosing spondylitis (Thoracic region)
0.000 0.283 0.717
M45.X3 Ankylosing spondylitis (Cervicothoracic region)
0.000 0.283 0.717
M45.X1 Ankylosing spondylitis (Occipito-atlanto-axial region)
0.000 0.283 0.717
E78.3 Hyperchylomicronaemia
0.000 0.283 0.717
E05.5 Thyroid crisis or storm
0.000 0.283 0.717
E05.4 Thyrotoxicosis factitia
0.000 0.283 0.717
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.283 0.717
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.283 0.717
M06.8 Other specified rheumatoid arthritis
0.000 0.283 0.717
M06.2 Rheumatoid bursitis
0.000 0.283 0.717
M06.1 Adult-onset Still's disease
0.000 0.283 0.717
E14.8 With unspecified complications
0.000 0.283 0.716
E14.7 With multiple complications
0.000 0.283 0.716
E14.0 With coma
0.000 0.283 0.716
E11.7 With multiple complications
0.000 0.283 0.716
M09 Juvenile arthritis in diseases classified elsewhere
0.000 0.284 0.716
M08 Juvenile arthritis
0.000 0.284 0.716
H65-H75 Diseases of middle ear and mastoid
0.000 0.284 0.716
E77 Disorders of glycoprotein metabolism
0.000 0.284 0.716
E76 Disorders of glycosaminoglycan metabolism
0.000 0.284 0.716
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.000 0.284 0.716
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.000 0.284 0.716
M91-M94 Chondropathies
0.000 0.286 0.714
M35.0 Sicca syndrome [Sjogren]
0.000 0.286 0.714
E74.3 Other disorders of intestinal carbohydrate absorption
0.000 0.286 0.714
L40.4 Guttate psoriasis
0.000 0.286 0.713
L40.2 Acrodermatitis continua
0.000 0.286 0.713
Chapter XVI Certain conditions originating in the perinatal period
0.000 0.287 0.713
I21.X Presumed acute myicardial infaction (unconfirmed)
0.000 0.287 0.713
E14.6 With other specified complications
0.000 0.289 0.711
E70 Disorders of aromatic amino-acid metabolism
0.000 0.290 0.710
L44 Other papulosquamous disorders
0.000 0.291 0.709
L41 Parapsoriasis
0.000 0.291 0.709
L45 Papulosquamous disorders in diseases classified elsewhere
0.000 0.291 0.709
F34 Persistent mood [affective] disorders
0.000 0.292 0.708
E23.6 Other disorders of pituitary gland
0.000 0.293 0.707
I08.0 Disorders of both mitral and aortic valves
0.000 0.294 0.706
H60.5 Acute otitis externa, non-infective
0.000 0.295 0.705
E21.3 Hyperparathyroidism, unspecified
0.000 0.298 0.702
H61.1 Non-infective disorders of pinna
0.000 0.301 0.699
G37 Other demyelinating diseases of central nervous system
0.698 0.301 0.000
E10.6 With other specified complications
0.000 0.302 0.698
M07.5 Arthropathy in ulcerative colitis
0.000 0.302 0.698
M07.4 Arthropathy in Crohn's disease [regional enteritis]
0.000 0.302 0.698
M07.2 Psoriatic spondylitis
0.000 0.302 0.698
M07.1 Arthritis mutilans
0.000 0.302 0.698
M07.0 Distal interphalangeal psoriatic arthropathy
0.000 0.302 0.698
E28.3 Primary ovarian failure
0.000 0.303 0.697
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.304 0.696
E32 Diseases of thymus
0.000 0.304 0.696
E31 Polyglandular dysfunction
0.000 0.304 0.696
E30 Disorders of puberty, not elsewhere classified
0.000 0.304 0.696
E25 Adrenogenital disorders
0.000 0.304 0.696
E16 Other disorders of pancreatic internal secretion
0.000 0.305 0.695
I24.9 Acute ischaemic heart disease, unspecified
0.000 0.308 0.692
F30.2 Mania with psychotic symptoms
0.000 0.309 0.691
I71 Aortic aneurysm and dissection
0.000 0.309 0.691
M34.1 CR(E)ST syndrome
0.000 0.309 0.691
I23.8 Other current complications following acute myocardial infarction
0.000 0.311 0.689
L42 Pityriasis rosea
0.000 0.312 0.688
I20.9 Angina pectoris, unspecified
0.000 0.313 0.687
M35.2 Behcet's disease
0.000 0.313 0.687
M07.38 Other psoriatic arthropathies (Other)
0.000 0.313 0.686
M07.34 Other psoriatic arthropathies (Hand)
0.000 0.313 0.686
M07.33 Other psoriatic arthropathies (Forearm)
0.000 0.313 0.686
M07.32 Other psoriatic arthropathies (Upper arm)
0.000 0.313 0.686
M07.31 Other psoriatic arthropathies (Shoulder region)
0.000 0.313 0.686
M32 Systemic lupus erythematosus
0.000 0.316 0.684
I12.0 Hypertensive renal disease with renal failure
0.000 0.316 0.684
E22.0 Acromegaly and pituitary gigantism
0.000 0.318 0.682
M95-M99 Other disorders of the musculoskeletal system and connective tissue
0.000 0.318 0.681
H60.1 Cellulitis of external ear
0.000 0.321 0.679
F32 Depressive episode
0.000 0.323 0.677
I71.9 Aortic aneurysm of unspecified site, without mention of rupture
0.000 0.323 0.677
M05.8 Other seropositive rheumatoid arthritis
0.000 0.326 0.674
M05.3 Rheumatoid arthritis with involvement of other organs and systems
0.000 0.326 0.674
M05.1 Rheumatoid lung disease
0.000 0.326 0.674
M05.0 Felty's syndrome
0.000 0.326 0.674
M75.2 Bicipital tendinitis
0.000 0.326 0.674
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.326 0.673
I79.2 Peripheral angiopathy in diseases classified elsewhere
0.000 0.328 0.672
E26 Hyperaldosteronism
0.000 0.332 0.668
H60.8 Other otitis externa
0.000 0.333 0.667
M06.30 Rheumatoid nodule (Multiple sites)
0.000 0.334 0.666
E14.2 Withrenal complications
0.000 0.335 0.665
E85.4 Organ-limited amyloidosis
0.000 0.335 0.664
G37.9 Demyelinating disease of central nervous system, unspecified
0.664 0.336 0.000
F80 Specific developmental disorders of speech and language
0.000 0.337 0.663
M12 Other specific arthropathies
0.000 0.338 0.662
I00-I02 Acute rheumatic fever
0.000 0.338 0.662
F31.7 Bipolar affective disorder, currently in remission
0.000 0.338 0.661
M06.39 Rheumatoid nodule (Site unspecified)
0.000 0.339 0.661
M06.38 Rheumatoid nodule (Other)
0.000 0.339 0.661
M06.36 Rheumatoid nodule (Lower leg)
0.000 0.339 0.661
M06.35 Rheumatoid nodule (Pelvic region and thigh)
0.000 0.339 0.661
M06.33 Rheumatoid nodule (Forearm)
0.000 0.339 0.661
M06.31 Rheumatoid nodule (Shoulder region)
0.000 0.339 0.661
M70.6 Trochanteric bursitis
0.000 0.341 0.659
E24 Cushing's syndrome
0.000 0.342 0.658
F90-F98 Behavioural and emotional disorders with onset usually occurring in childhood and adolescence
0.000 0.342 0.657
F38 Other mood [affective] disorders
0.000 0.343 0.657
M46 Other inflammatory spondylopathies
0.000 0.344 0.656
E07.8 Other specified disorders of thyroid
0.000 0.344 0.656
I74.3 Embolism and thrombosis of arteries of the lower extremities
0.000 0.345 0.655
F31.8 Other bipolar affective disorders
0.000 0.345 0.655
F31.2 Bipolar affective disorder, current episode manic with psychotic symptoms
0.000 0.346 0.654
E27.3 Drug-induced adrenocortical insufficiency
0.000 0.346 0.654
I22.0 Subsequent myocardial infarction of anterior wall
0.000 0.347 0.653
M05.98 Seropositive rheumatoid arthritis, unspecified (Other)
0.000 0.347 0.653
M05.95 Seropositive rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.000 0.347 0.653
M05.94 Seropositive rheumatoid arthritis, unspecified (Hand)
0.000 0.347 0.653
M05.93 Seropositive rheumatoid arthritis, unspecified (Forearm)
0.000 0.347 0.653
M05.92 Seropositive rheumatoid arthritis, unspecified (Upper arm)
0.000 0.347 0.653
M05.91 Seropositive rheumatoid arthritis, unspecified (Shoulder region)
0.000 0.347 0.653
E40-E46 Malnutrition
0.000 0.347 0.653
M35.7 Hypermobility syndrome
0.000 0.351 0.649
I15.1 Hypertension secondary to other renal disorders
0.000 0.351 0.649
E72 Other disorders of amino-acid metabolism
0.000 0.352 0.648
I24.1 Dressler's syndrome
0.000 0.352 0.648
I13 Hypertensive heart and renal disease
0.000 0.352 0.648
L10-L14 Bullous disorders
0.000 0.352 0.647
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.353 0.647
F81 Specific developmental disorders of scholastic skills
0.000 0.353 0.646
H62 Disorders of external ear in diseases classified elsewhere
0.000 0.354 0.646
E03.1 Congenital hypothyroidism without goitre
0.000 0.356 0.644
L43.3 Subacute (active) lichen planus
0.000 0.357 0.643
L43.2 Lichenoid drug reaction
0.000 0.357 0.643
L43.1 Bullous lichen planus
0.000 0.357 0.643
L43.0 Hypertrophic lichen planus
0.000 0.357 0.643
M07.6 Other enteropathic arthropathies
0.000 0.358 0.642
E06.5 Other chronic thyroiditis
0.000 0.362 0.638
E06.4 Drug-induced thyroiditis
0.000 0.362 0.638
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.362 0.638
E06.1 Subacute thyroiditis
0.000 0.362 0.638
E06.0 Acute thyroiditis
0.000 0.362 0.638
E03.8 Other specified hypothyroidism
0.000 0.362 0.638
F99-F99 Unspecified mental disorder
0.000 0.362 0.638
F30.8 Other manic episodes
0.000 0.362 0.637
F30.1 Mania without psychotic symptoms
0.000 0.362 0.637
M70.5 Other bursitis of knee
0.000 0.363 0.637
E06.9 Thyroiditis, unspecified
0.000 0.363 0.637
M34.9 Systemic sclerosis, unspecified
0.000 0.366 0.634
M11 Other crystal arthropathies
0.000 0.368 0.632
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.000 0.368 0.631
L00-L08 Infections of the skin and subcutaneous tissue
0.000 0.370 0.630
I70.9 Generalised and unspecified atherosclerosis
0.000 0.370 0.630
L40.3 Pustulosis palmaris et plantaris
0.000 0.371 0.629
I70.0 Atherosclerosis of aorta
0.000 0.372 0.628
M73 Soft tissue disorders in diseases classified elsewhere
0.000 0.372 0.628
E28.9 Ovarian dysfunction, unspecified
0.000 0.373 0.627
E28.8 Other ovarian dysfunction
0.000 0.373 0.627
E28.1 Androgen excess
0.000 0.373 0.627
E28.0 Oestrogen excess
0.000 0.373 0.627
E89.3 Postprocedural hypopituitarism
0.000 0.374 0.626
E23.2 Diabetes insipidus
0.000 0.377 0.623
E11.6 With other specified complications
0.000 0.377 0.623
M05.97 Seropositive rheumatoid arthritis, unspecified (Ankle and foot)
0.000 0.378 0.622
E07.1 Dyshormogenetic goitre
0.000 0.378 0.622
E07.0 Hypersecretion of calcitonin
0.000 0.378 0.622
I09 Other rheumatic heart diseases
0.000 0.378 0.622
M24 Other specific joint derangements
0.000 0.381 0.619
E11.8 With unspecified complications
0.000 0.383 0.617
H61.3 Acquired stenosis of external ear canal
0.000 0.384 0.616
M07.35 Other psoriatic arthropathies (Pelvic region and thigh)
0.000 0.384 0.616
M70.2 Olecranon bursitis
0.000 0.384 0.616
M75.3 Calcific tendinitis of shoulder
0.000 0.384 0.616
M70.9 Unspecified soft tissue disorder related to use, overuse and pressure
0.000 0.385 0.615
M70.8 Other soft tissue disorders related to use, overuse and pressure
0.000 0.385 0.615
M70.1 Bursitis of hand
0.000 0.385 0.615
M70.0 Chronic crepitant synovitis of hand and wrist
0.000 0.385 0.615
M06.4 Inflammatory polyarthropathy
0.000 0.385 0.615
H60.2 Malignant otitis externa
0.000 0.386 0.614
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.000 0.388 0.611
E23.1 Drug-induced hypopituitarism
0.000 0.388 0.611
H66 Suppurative and unspecified otitis media
0.000 0.389 0.611
E20 Hypoparathyroidism
0.000 0.391 0.609
I15.8 Other secondary hypertension
0.000 0.391 0.609
I15.2 Hypertension secondary to endocrine disorders
0.000 0.391 0.609
I70.1 Atherosclerosis of renal artery
0.000 0.392 0.607
M70.49 Prepatellar bursitis-Site unspec
0.000 0.393 0.607
M70.48 Prepatellar bursitis-Other
0.000 0.393 0.607
M70.47 Prepatellar bursitis-Ankle/Foot
0.000 0.393 0.607
M70.45 Prepatellar bursitis-Pelvic/Thigh
0.000 0.393 0.607
M70.44 Prepatellar bursitis-Hand
0.000 0.393 0.607
M70.43 Prepatellar bursitis-Forearm
0.000 0.393 0.607
M70.42 Prepatellar bursitis-Upper arm
0.000 0.393 0.607
M70.41 Prepatellar bursitis-Shldr region
0.000 0.393 0.607
M70.40 Prepatellar bursitis-Mult sites
0.000 0.393 0.607
E80 Disorders of porphyrin and bilirubin metabolism
0.000 0.393 0.607
I08.8 Other multiple valve diseases
0.000 0.393 0.607
F60-F69 Disorders of adult personality and behaviour
0.000 0.393 0.607
E27.5 Adrenomedullary hyperfunction
0.000 0.395 0.605
E27.0 Other adrenocortical overactivity
0.000 0.395 0.605
F70-F79 Mental retardation
0.000 0.396 0.604
M00-M03 Infectious arthropathies
0.000 0.397 0.603
M33 Dermatopolymyositis
0.000 0.398 0.602
I73.9 Peripheral vascular disease, unspecified
0.000 0.398 0.602
M35.9 Systemic involvement of connective tissue, unspecified
0.000 0.398 0.602
M35.6 Relapsing panniculitis [Weber-Christian]
0.000 0.398 0.602
M35.5 Multifocal fibrosclerosis
0.000 0.398 0.602
M35.4 Diffuse (eosinophilic) fasciitis
0.000 0.398 0.602
H66.3 Other chronic suppurative otitis media
0.000 0.399 0.601
I21.0 Acute transmural myocardial infarction of anterior wall
0.000 0.400 0.600
M36 Systemic disorders of connective tissue in diseases classified elsewhere
0.000 0.400 0.599
I11 Hypertensive heart disease
0.000 0.402 0.598
M05.96 Seropositive rheumatoid arthritis, unspecified (Lower leg)
0.000 0.404 0.596
E85.9 Amyloidosis, unspecified
0.000 0.405 0.595
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.000 0.405 0.595
F84 Pervasive developmental disorders
0.000 0.407 0.593
M75.8 Other shoulder lesions
0.000 0.409 0.590
E15 Nondiabetic hypoglycaemic coma
0.000 0.410 0.590
E05.8 Other thyrotoxicosis
0.000 0.411 0.589
I70.8 Atherosclerosis of other arteries
0.000 0.412 0.587
I23.6 Thrombosis of atrium, auricular appendage and ventricle as current complications following acute myocardial infarction
0.000 0.413 0.587
I23.5 Rupture of papillary muscle as current complication following acute myocardial infarction
0.000 0.413 0.587
I23.4 Rupture of chordae tendineae as current complication following acute myocardial infarction
0.000 0.413 0.587
I23.3 Rupture of cardiac wall without haemopericardium as current complication following acute myocardial infarction
0.000 0.413 0.587
I23.2 Ventricular septal defect as current complication following acute myocardial infarction
0.000 0.413 0.587
I23.1 Atrial septal defect as current complication following acute myocardial infarction
0.000 0.413 0.587
I23.0 Haemopericardium as current complication following acute myocardial infarction
0.000 0.413 0.587
I15.0 Renovascular hypertension
0.000 0.414 0.586
I24.0 Coronary thrombosis not resulting in myocardial infarction
0.000 0.414 0.586
H71 Cholesteatoma of middle ear
0.000 0.416 0.584
E13 Other specified diabetes mellitus
0.000 0.416 0.583
E27.4 Other and unspecified adrenocortical insufficiency
0.000 0.419 0.581
M49.5 Collapsed vertebra in diseases classified elsewhere
0.000 0.419 0.581
I73.0 Raynaud's syndrome
0.000 0.419 0.581
F31.4 Bipolar affective disorder, current episode severe depression without psychotic symptoms
0.000 0.420 0.580
E74.9 Disorder of carbohydrate metabolism, unspecified
0.000 0.421 0.579
E74.8 Other specified disorders of carbohydrate metabolism
0.000 0.421 0.579
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
0.000 0.421 0.579
E74.2 Disorders of galactose metabolism
0.000 0.421 0.579
E74.1 Disorders of fructose metabolism
0.000 0.421 0.579
M07.39 Other psoriatic arthropathies (Site unspecified)
0.000 0.421 0.579
E83 Disorders of mineral metabolism
0.101 0.421 0.478
M70.3 Other bursitis of elbow
0.000 0.423 0.577
H73 Other disorders of tympanic membrane
0.000 0.423 0.577
M32.1 Systemic lupus erythematosus with organ or system involvement
0.000 0.425 0.575
M46.9 Inflammatory spondylopathy, unspecified
0.000 0.426 0.574
E16.2 Hypoglycaemia, unspecified
0.000 0.426 0.574
F89 Unspecified disorder of psychological development
0.000 0.427 0.573
F88 Other disorders of psychological development
0.000 0.427 0.573
F83 Mixed specific developmental disorders
0.000 0.427 0.573
F82 Specific developmental disorder of motor function
0.000 0.427 0.573
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.427 0.573
E22.8 Other hyperfunction of pituitary gland
0.000 0.427 0.573
H60.4 Cholesteatoma of external ear
0.000 0.429 0.571
M93 Other osteochondropathies
0.000 0.429 0.571
M05.2 Rheumatoid vasculitis
0.000 0.430 0.569
E65-E68 Obesity and other hyperalimentation
0.000 0.432 0.568
F80.1 Expressive language disorder
0.000 0.434 0.566
H74 Other disorders of middle ear and mastoid
0.000 0.435 0.565
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.436 0.564
M34.8 Other forms of systemic sclerosis
0.000 0.437 0.563
E50-E64 Other nutritional deficiencies
0.000 0.439 0.561
F34.1 Dysthymia
0.000 0.441 0.559
E34 Other endocrine disorders
0.000 0.442 0.558
H61.8 Other specified disorders of external ear
0.000 0.442 0.558
H60.0 Abscess of external ear
0.000 0.444 0.556
F32.3 Severe depressive episode with psychotic symptoms
0.000 0.444 0.556
M35.8 Other specified systemic involvement of connective tissue
0.000 0.444 0.556
F50-F59 Behavioural syndromes associated with physiological disturbances and physical factors
0.000 0.446 0.554
M14 Arthropathies in other diseases classified elsewhere
0.000 0.447 0.553
E85.2 Heredofamilial amyloidosis, unspecified
0.000 0.447 0.553
E85.1 Neuropathic heredofamilial amyloidosis
0.000 0.447 0.553
E85.0 Nonneuropathic heredofamilial amyloidosis
0.000 0.447 0.553
M34.2 Systemic sclerosis induced by drugs and chemicals
0.000 0.447 0.552
M34.0 Progressive systemic sclerosis
0.000 0.447 0.552
M79 Other soft tissue disorders, not elsewhere classified
0.000 0.449 0.551
M06.0 Seronegative rheumatoid arthritis
0.000 0.449 0.550
I79.8 Other disorders of arteries, arterioles and capillaries in diseases classified elsewhere
0.000 0.450 0.549
I79.1 Aortitis in diseases classified elsewhere
0.000 0.450 0.549
I79.0 Aneurysm of aorta in diseases classified elsewhere
0.000 0.450 0.549
M70.7 Other bursitis of hip
0.000 0.451 0.549
E89.6 Postprocedural adrenocortical(-medullary) hypofunction
0.000 0.452 0.548
I25.3 Aneurysm of heart
0.000 0.452 0.548
I73.1 Thromboangiitis obliterans [Buerger]
0.000 0.453 0.547
E21.2 Other hyperparathyroidism
0.000 0.453 0.547
F32.1 Moderate depressive episode
0.000 0.454 0.546
E21.5 Disorder of parathyroid gland, unspecified
0.000 0.455 0.545
F32.0 Mild depressive episode
0.000 0.455 0.545
E21.4 Other specified disorders of parathyroid gland
0.000 0.456 0.543
E16.1 Other hypoglycaemia
0.000 0.459 0.541
M49.8 Spondylopathy in other diseases classified elsewhere
0.000 0.459 0.541
M49.4 Neuropathic spondylopathy
0.000 0.459 0.541
M49.3 Spondylopathy in other infectious and parasitic diseases classified elsewhere
0.000 0.459 0.541
M49.2 Enterobacterial spondylitis
0.000 0.459 0.541
M49.1 Brucella spondylitis
0.000 0.459 0.541
M49.0 Tuberculosis of spine
0.000 0.459 0.541
E73.9 Lactose intolerance, unspecified
0.000 0.459 0.541
I74.5 Embolism and thrombosis of iliac artery
0.000 0.460 0.540
E86 Volume depletion
0.000 0.460 0.540
I21.3 Acute transmural myocardial infarction of unspecified site
0.000 0.461 0.539
E22.1 Hyperprolactinaemia
0.000 0.462 0.538
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
0.000 0.462 0.538
E29.1 Testicular hypofunction
0.000 0.463 0.537
I74.1 Embolism and thrombosis of other and unspecified parts of aorta
0.000 0.463 0.537
F81.9 Developmental disorder of scholastic skills, unspecified
0.000 0.463 0.537
M60-M63 Disorders of muscles
0.000 0.464 0.535
M24.0 Loose body in joint
0.000 0.472 0.528
F39 Unspecified mood [affective] disorder
0.000 0.472 0.528
I74.9 Embolism and thrombosis of unspecified artery
0.000 0.474 0.526
E73.8 Other lactose intolerance
0.000 0.475 0.525
E73.1 Secondary lactase deficiency
0.000 0.475 0.525
E73.0 Congenital lactase deficiency
0.000 0.475 0.525
L55-L59 Radiation-related disorders of the skin and subcutaneous tissue
0.000 0.475 0.525
E79.9 Disorder of purine and pyrimidine metabolism, unspecified
0.000 0.476 0.523
E79.8 Other disorders of purine and pyrimidine metabolism
0.000 0.476 0.523
E79.1 Lesch-Nyhan syndrome
0.000 0.476 0.523
E24.2 Drug-induced Cushing's syndrome
0.000 0.478 0.522

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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