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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs2621379
log Bayes Factor = 53.1967
Chromosome 6   position 32,762,792  (GRCh37) Explore rs2621379 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E10.9 Without complications
0.000 0.000 1.000
K90.0 Coeliac disease
0.000 0.000 1.000
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
E10-E14 Diabetes mellitus
0.000 0.000 1.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.000 1.000
E10.3 With ophthalmic complications
0.000 0.000 1.000
G35 Multiple sclerosis
1.000 0.000 0.000
E00-E07 Disorders of thyroid gland
0.000 0.000 1.000
E11 Non-insulin-dependent diabetes mellitus
0.000 0.000 1.000
L40.5 Arthropathic psoriasis
0.000 0.000 1.000
E05.9 Thyrotoxicosis, unspecified
0.000 0.000 1.000
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.000 1.000
E11.3 With ophthalmic complications
0.000 0.001 0.999
E20-E35 Disorders of other endocrine glands
0.000 0.004 0.996
L40 Psoriasis
0.000 0.006 0.994
G35-G37 Demyelinating diseases of the central nervous system
0.991 0.009 0.000
H36.0 Diabetic retinopathy
0.000 0.011 0.989
G37 Other demyelinating diseases of central nervous system
0.989 0.011 0.000
E27 Other disorders of adrenal gland
0.000 0.015 0.985
G37.9 Demyelinating disease of central nervous system, unspecified
0.980 0.020 0.000
E03 Other hypothyroidism
0.000 0.020 0.980
L40.9 Psoriasis, unspecified
0.000 0.022 0.978
E27.1 Primary adrenocortical insufficiency
0.000 0.024 0.976
E11.9 Without complications
0.000 0.025 0.975
E03.9 Hypothyroidism, unspecified
0.000 0.028 0.972
E10.1 With ketoacidosis
0.000 0.030 0.970
E10.5 With peripheral circulatory complications
0.000 0.035 0.965
L57.0 Actinic keratosis
0.000 0.036 0.964
E10.2 With renal complications
0.000 0.038 0.962
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.042 0.958
C44 Other malignant neoplasms of skin
0.000 0.055 0.945
E10.4 With neurological complications
0.000 0.056 0.944
C44.6 Skin of upper limb, including shoulder
0.000 0.058 0.942
C44.7 Skin of lower limb, including hip
0.000 0.061 0.939
E16 Other disorders of pancreatic internal secretion
0.000 0.073 0.927
D04 Carcinoma in situ of skin
0.000 0.083 0.917
C43-C44 Melanoma and other malignant neoplasms of skin
0.000 0.084 0.916
E70-E90 Metabolic disorders
0.000 0.084 0.916
C81-C96 Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissue
0.000 0.085 0.915
C44.3 Skin of other and unspecified parts of face
0.000 0.085 0.915
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.000 0.086 0.914
C82 Follicular [nodular] non-Hodgkin's lymphoma
0.000 0.086 0.914
L40-L45 Papulosquamous disorders
0.000 0.093 0.907
C85 Other and unspecified types of non-Hodgkin's lymphoma
0.000 0.093 0.907
E89.0 Postprocedural hypothyroidism
0.000 0.095 0.905
D00-D09 In situ neoplasms
0.000 0.099 0.901
Chapter II Neoplasms
0.000 0.100 0.900
G37.8 Other specified demyelinating diseases of central nervous system
0.899 0.101 0.000
C85.9 Non-Hodgkin's lymphoma, unspecified type
0.000 0.101 0.899
D04.5 Skin of trunk
0.000 0.102 0.898
C82.9 Follicular non-Hodgkin's lymphoma, unspecified
0.000 0.106 0.894
L57 Skin changes due to chronic exposure to nonionising radiation
0.000 0.106 0.894
C44.4 Skin of scalp and neck
0.000 0.119 0.881
D04.7 Skin of lower limb, including hip
0.000 0.123 0.877
E24 Cushing's syndrome
0.000 0.124 0.876
L55-L59 Radiation-related disorders of the skin and subcutaneous tissue
0.000 0.127 0.873
E23 Hypofunction and other disorders of pituitary gland
0.000 0.127 0.873
E16.2 Hypoglycaemia, unspecified
0.000 0.132 0.868
H36 Retinal disorders in diseases classified elsewhere
0.000 0.133 0.867
Chapter XII Diseases of the skin and subcutaneous tissue
0.000 0.140 0.860
E28 Ovarian dysfunction
0.000 0.145 0.855
E27.4 Other and unspecified adrenocortical insufficiency
0.000 0.148 0.852
E11.5 With peripheral circulatory complications
0.000 0.156 0.844
E10.0 With coma
0.000 0.157 0.843
D04.3 Skin of other and unspecified parts of face
0.000 0.158 0.842
L40.3 Pustulosis palmaris et plantaris
0.000 0.159 0.841
E11.0 With coma
0.000 0.160 0.840
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.000 0.176 0.824
G37.3 Acute transverse myelitis in demyelinating disease of central nervous system
0.822 0.177 0.000
C83 Diffuse non-Hodgkin's lymphoma
0.000 0.186 0.814
L40.1 Generalised pustular psoriasis
0.000 0.192 0.808
C82.0 Small cleaved cell, follicular
0.000 0.192 0.808
E23.7 Disorder of pituitary gland, unspecified
0.000 0.196 0.804
C73-C75 Malignant neoplasms of thyroid and other endocrine glands
0.000 0.204 0.796
# Top node
0.000 0.205 0.795
C91 Lymphoid leukaemia
0.000 0.210 0.790
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.212 0.788
E10.7 With multiple complications
0.000 0.213 0.787
D09 Carcinoma in situ of other and unspecified sites
0.000 0.213 0.787
E13 Other specified diabetes mellitus
0.000 0.214 0.786
D04.4 Skin of scalp and neck
0.000 0.214 0.786
H30-H36 Disorders of choroid and retina
0.000 0.220 0.780
C83.3 Large cell (diffuse)
0.000 0.221 0.779
E65-E68 Obesity and other hyperalimentation
0.000 0.225 0.775
E23.6 Other disorders of pituitary gland
0.000 0.226 0.774
C82.2 Large cell, follicular
0.000 0.227 0.773
E24.2 Drug-induced Cushing's syndrome
0.000 0.230 0.770
G36 Other acute disseminated demyelination
0.770 0.230 0.000
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.000 0.237 0.763
E78.6 Lipoprotein deficiency
0.000 0.239 0.761
E89.3 Postprocedural hypopituitarism
0.000 0.241 0.759
E79 Disorders of purine and pyrimidine metabolism
0.000 0.243 0.757
C88 Malignant immunoproliferative diseases
0.000 0.246 0.754
H35 Other retinal disorders
0.000 0.247 0.753
L40.4 Guttate psoriasis
0.000 0.247 0.753
E10.6 With other specified complications
0.000 0.248 0.752
C82.4 Follicular lymphoma grade IIIb
0.000 0.248 0.752
E89.6 Postprocedural adrenocortical(-medullary) hypofunction
0.000 0.252 0.748
E16.1 Other hypoglycaemia
0.000 0.253 0.747
E78.2 Mixed hyperlipidaemia
0.000 0.257 0.743
D04.6 Skin of upper limb, including shoulder
0.000 0.257 0.743
E89.2 Postprocedural hypoparathyroidism
0.000 0.265 0.735
C73 Malignant neoplasm of thyroid gland
0.000 0.267 0.733
C85.2 Mediastinal (thymic) large B-cell lymphoma
0.000 0.267 0.733
Chapter VII Diseases of the eye and adnexa
0.000 0.269 0.731
E27.3 Drug-induced adrenocortical insufficiency
0.000 0.270 0.730
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.000 0.276 0.724
E40-E46 Malnutrition
0.000 0.279 0.721
M07.39 Other psoriatic arthropathies (Site unspecified)
0.000 0.280 0.720
E28.2 Polycystic ovarian syndrome
0.000 0.281 0.719
M07.3 Other psoriatic arthropathies
0.000 0.282 0.718
E05.5 Thyroid crisis or storm
0.000 0.283 0.717
E05.4 Thyrotoxicosis factitia
0.000 0.283 0.717
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.283 0.717
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.283 0.717
E12 Malnutrition-related diabetes mellitus
0.000 0.283 0.717
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.283 0.717
E00 Congenital iodine-deficiency syndrome
0.000 0.283 0.717
E11.7 With multiple complications
0.000 0.283 0.717
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.283 0.716
D04.9 Skin, unspecified
0.000 0.284 0.716
C91.9 Lymphoid leukaemia, unspecified
0.000 0.284 0.716
C82.7 Other types of follicular non-Hodgkin's lymphoma
0.000 0.285 0.715
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.286 0.714
E32 Diseases of thymus
0.000 0.286 0.714
E31 Polyglandular dysfunction
0.000 0.286 0.714
E30 Disorders of puberty, not elsewhere classified
0.000 0.286 0.714
E89.4 Postprocedural ovarian failure
0.000 0.287 0.713
L40.2 Acrodermatitis continua
0.000 0.287 0.713
E26 Hyperaldosteronism
0.000 0.289 0.711
G37.5 Concentric sclerosis [Balo]
0.709 0.291 0.000
G37.4 Subacute necrotising myelitis
0.709 0.291 0.000
G37.2 Central pontine myelinolysis
0.709 0.291 0.000
G37.1 Central demyelination of corpus callosum
0.709 0.291 0.000
G37.0 Diffuse sclerosis
0.709 0.291 0.000
M07.30 Other psoriatic arthropathies (Multiple sites)
0.000 0.292 0.708
E27.5 Adrenomedullary hyperfunction
0.000 0.294 0.706
E27.0 Other adrenocortical overactivity
0.000 0.294 0.706
E10.8 With unspecified complications
0.000 0.294 0.706
E88 Other metabolic disorders
0.000 0.294 0.706
Q80-Q89 Other congenital malformations
0.000 0.294 0.706
E03.1 Congenital hypothyroidism without goitre
0.000 0.295 0.705
H35.2 Other proliferative retinopathy
0.000 0.295 0.705
C82.1 Mixed small cleaved and large cell, follicular
0.000 0.295 0.705
D04.2 Skin of ear and external auricular canal
0.000 0.296 0.704
E03.5 Myxoedema coma
0.000 0.297 0.703
E03.4 Atrophy of thyroid (acquired)
0.000 0.297 0.703
E03.3 Postinfectious hypothyroidism
0.000 0.297 0.703
H35.8 Other specified retinal disorders
0.000 0.300 0.700
E24.0 Pituitary-dependent Cushing's disease
0.000 0.302 0.698
E65 Localised adiposity
0.000 0.303 0.697
E11.2 With renal complications
0.000 0.303 0.697
D09.0 Bladder
0.000 0.304 0.696
Q85 Phakomatoses, not elsewhere classified
0.000 0.310 0.690
C85.1 B-cell lymphoma, unspecified
0.000 0.313 0.687
E70 Disorders of aromatic amino-acid metabolism
0.000 0.313 0.687
E15 Nondiabetic hypoglycaemic coma
0.000 0.313 0.686
E05.8 Other thyrotoxicosis
0.000 0.314 0.685
E78.5 Hyperlipidaemia, unspecified
0.000 0.316 0.684
Q60-Q64 Congenital malformations of the urinary system
0.000 0.317 0.683
D37-D48 Neoplasms of uncertain or unknown behaviour
0.000 0.318 0.682
D06 Carcinoma in situ of cervix uteri
0.000 0.321 0.679
E89.8 Other postprocedural endocrine and metabolic disorders
0.000 0.322 0.678
C44.8 Overlapping lesion of skin
0.000 0.323 0.677
E28.3 Primary ovarian failure
0.000 0.324 0.676
C83.7 Burkitt's tumour
0.000 0.325 0.675
E06 Thyroiditis
0.000 0.325 0.674
E27.2 Addisonian crisis
0.000 0.326 0.674
Q61 Cystic kidney disease
0.000 0.327 0.673
C88.4 Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue [MALT-lymphoma]
0.000 0.328 0.672
E25 Adrenogenital disorders
0.000 0.330 0.670
D43 Neoplasm of uncertain or unknown behaviour of brain and central nervous system
0.000 0.332 0.668
E22 Hyperfunction of pituitary gland
0.000 0.332 0.667
D00 Carcinoma in situ of oral cavity, oesophagus and stomach
0.000 0.333 0.667
Q50-Q56 Congenital malformations of genital organs
0.000 0.333 0.667
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.335 0.665
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.335 0.665
E16.4 Abnormal secretion of gastrin
0.000 0.335 0.665
E16.3 Increased secretion of glucagon
0.000 0.335 0.665
D04.1 Skin of eyelid, including canthus
0.000 0.342 0.658
D04.8 Skin of other sites
0.000 0.342 0.657
D04.0 Skin of lip
0.000 0.342 0.657
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.342 0.657
E77 Disorders of glycoprotein metabolism
0.000 0.343 0.656
E76 Disorders of glycosaminoglycan metabolism
0.000 0.343 0.656
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.000 0.343 0.656
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.000 0.343 0.656
C96 Other and unspecified malignant neoplasms of lymphoid, haematopoietic and related tissue
0.000 0.344 0.656
E89.9 Postprocedural endocrine and metabolic disorder, unspecified
0.000 0.345 0.655
E89.5 Postprocedural testicular hypofunction
0.000 0.345 0.655
C82.6 Cutaneous follicle centre lymphoma
0.000 0.345 0.655
C82.5 Diffuse follicle centre lymphoma
0.000 0.345 0.655
M07.36 Other psoriatic arthropathies (Lower leg)
0.000 0.345 0.655
C91.0 Acute lymphoblastic leukaemia
0.000 0.346 0.654
E84 Cystic fibrosis
0.000 0.347 0.653
Q85.8 Other phakomatoses, not elsewhere classified
0.000 0.348 0.652
L44 Other papulosquamous disorders
0.000 0.350 0.650
L45 Papulosquamous disorders in diseases classified elsewhere
0.000 0.350 0.650
C85.0 Lymphosarcoma
0.000 0.350 0.650
E11.6 With other specified complications
0.000 0.351 0.649
C97-C97 Malignant neoplasms of independent (primary) multiple sites
0.000 0.353 0.647
H83.0 Labyrinthitis
0.000 0.354 0.646
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
0.000 0.356 0.644
Chapter VIII Diseases of the ear and mastoid process
0.000 0.357 0.643
L43 Lichen planus
0.000 0.357 0.643
H30 Chorioretinal inflammation
0.000 0.357 0.643
H83 Other diseases of inner ear
0.000 0.358 0.642
L57.5 Actinic granuloma
0.000 0.359 0.641
L57.3 Poikiloderma of Civatte
0.000 0.359 0.641
L57.2 Cutis rhomboidalis nuchae
0.000 0.359 0.641
L57.1 Actinic reticuloid
0.000 0.359 0.641
L59 Other disorders of skin and subcutaneous tissue related to radiation
0.000 0.360 0.640
H35.6 Retinal haemorrhage
0.000 0.360 0.640
E29 Testicular dysfunction
0.000 0.361 0.639
D43.0 Brain, supratentorial
0.000 0.363 0.637
E11.8 With unspecified complications
0.000 0.364 0.636
H80-H83 Diseases of inner ear
0.000 0.364 0.636
C94 Other leukaemias of specified cell type
0.000 0.365 0.635
C83.1 Small cleaved cell (diffuse)
0.000 0.365 0.635
E80 Disorders of porphyrin and bilirubin metabolism
0.000 0.366 0.633
C83.9 Diffuse non-Hodgkin's lymphoma, unspecified
0.000 0.367 0.633
E27.9 Disorder of adrenal gland, unspecified
0.000 0.368 0.632
L41 Parapsoriasis
0.000 0.369 0.631
D47 Other neoplasms of uncertain or unknown behaviour of lymphoid, haematopoietic and related tissue
0.000 0.369 0.631
E24.8 Other Cushing's syndrome
0.000 0.372 0.628
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.000 0.372 0.628
E24.3 Ectopic ACTH syndrome
0.000 0.372 0.628
E24.1 Nelson's syndrome
0.000 0.372 0.628
E27.8 Other specified disorders of adrenal gland
0.000 0.372 0.628
Q61.3 Polycystic kidney, unspecified
0.000 0.374 0.626
L55 Sunburn
0.000 0.374 0.626
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.000 0.374 0.626
E23.1 Drug-induced hypopituitarism
0.000 0.374 0.626
E78.1 Pure hyperglyceridaemia
0.000 0.375 0.625
E03.8 Other specified hypothyroidism
0.000 0.376 0.624
L56 Other acute skin changes due to ultraviolet radiation
0.000 0.376 0.623
D02 Carcinoma in situ of middle ear and respiratory system
0.000 0.377 0.623
C91.5 Adult T-cell leukaemia
0.000 0.378 0.622
H36.8 Other retinal disorders in diseases classified elsewhere
0.000 0.378 0.622
C00-C14 Malignant neoplasms of lip, oral cavity and pharynx
0.000 0.379 0.621
M07.37 Other psoriatic arthropathies (Ankle and foot)
0.000 0.379 0.621
E83.1 Disorders of iron metabolism
0.618 0.381 0.001
E89.1 Postprocedural hypoinsulinaemia
0.000 0.381 0.619
Q85.9 Phakomatosis, unspecified
0.000 0.383 0.617
C86 Other specified types of T/NK-cell lymphoma
0.000 0.383 0.616
C93 Monocytic leukaemia
0.000 0.385 0.615
E21.3 Hyperparathyroidism, unspecified
0.000 0.386 0.614
E34 Other endocrine disorders
0.000 0.386 0.614
E28.9 Ovarian dysfunction, unspecified
0.000 0.387 0.613
E28.8 Other ovarian dysfunction
0.000 0.387 0.613
E28.1 Androgen excess
0.000 0.387 0.613
E28.0 Oestrogen excess
0.000 0.387 0.613
E13.3 With ophthalmic complications
0.000 0.387 0.613
L10-L14 Bullous disorders
0.000 0.388 0.612
H35.0 Background retinopathy and retinal vascular changes
0.000 0.389 0.611
G36.0 Neuromyelitis optica [Devic]
0.611 0.389 0.000
C44.0 Skin of lip
0.000 0.393 0.607
Q61.0 Congenital single renal cyst
0.000 0.394 0.606
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.000 0.398 0.602
E88.8 Other specified metabolic disorders
0.000 0.398 0.602
L57.9 Skin changes due to chronic exposure to nonionising radiation, unspecified
0.000 0.399 0.601
D03 Melanoma in situ
0.000 0.399 0.601
E20 Hypoparathyroidism
0.000 0.400 0.599
Q61.9 Cystic kidney disease, unspecified
0.000 0.400 0.600
D43.2 Brain, unspecified
0.000 0.401 0.599
E24.9 Cushing's syndrome, unspecified
0.000 0.402 0.598
L42 Pityriasis rosea
0.000 0.405 0.595
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.000 0.409 0.591
L58 Radiodermatitis
0.000 0.409 0.591
E13.9 Without complications
0.000 0.410 0.590
C74 Malignant neoplasm of adrenal gland
0.000 0.411 0.589
E85 Amyloidosis
0.000 0.411 0.589
C44.2 Skin of ear and external auricular canal
0.000 0.413 0.587
C95 Leukaemia of unspecified cell type
0.000 0.413 0.586
L40.0 Psoriasis vulgaris
0.000 0.414 0.586
C83.6 Undifferentiated (diffuse)
0.000 0.416 0.584
C83.4 Immunoblastic (diffuse)
0.000 0.416 0.584
C83.2 Mixed small and large cell (diffuse)
0.000 0.416 0.584
D01 Carcinoma in situ of other and unspecified digestive organs
0.000 0.417 0.583
E06.3 Autoimmune thyroiditis
0.000 0.417 0.583
H49-H52 Disorders of ocular muscles, binocular movement, accommodation and refraction
0.000 0.417 0.583
E21.4 Other specified disorders of parathyroid gland
0.000 0.420 0.580
Q83 Congenital malformations of breast
0.000 0.421 0.578
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.422 0.578
D09.9 Carcinoma in situ, unspecified
0.000 0.422 0.578
C82.3 Follicular lymphoma grade IIIa
0.000 0.423 0.577
M07.34 Other psoriatic arthropathies (Hand)
0.000 0.424 0.576
Chapter XVI Certain conditions originating in the perinatal period
0.000 0.424 0.576
E73 Lactose intolerance
0.000 0.427 0.573
E78.9 Disorder of lipoprotein metabolism, unspecified
0.000 0.428 0.572
D09.1 Other and unspecified urinary organs
0.000 0.429 0.571
E26.9 Hyperaldosteronism, unspecified
0.000 0.429 0.571
C43 Malignant melanoma of skin
0.000 0.431 0.569
C91.8 Mature B-cell leukaemia Burkitt-type
0.000 0.433 0.567
C91.7 Other lymphoid leukaemia
0.000 0.433 0.567
C91.6 Prolymphocytic leukaemia of T-cell type
0.000 0.433 0.567
C91.3 Prolymphocytic leukaemia
0.000 0.433 0.567
C91.2 Subacute lymphocytic leukaemia
0.000 0.433 0.567
C85.7 Other specified types of non-Hodgkin's lymphoma
0.000 0.435 0.565
D09.7 Carcinoma in situ of other specified sites
0.000 0.436 0.564
D09.3 Thyroid and other endocrine glands
0.000 0.436 0.564
D09.2 Eye
0.000 0.436 0.564
E13.8 With unspecified complications
0.000 0.436 0.564
E13.7 With multiple complications
0.000 0.436 0.564
E13.6 With other specified complications
0.000 0.436 0.564
E13.5 With peripheral circulatory complications
0.000 0.436 0.564
E13.4 With neurological complications
0.000 0.436 0.564
E13.2 With renal complications
0.000 0.436 0.564
E13.1 With ketoacidosis
0.000 0.436 0.564
E13.0 With coma
0.000 0.436 0.564
H50 Other strabismus
0.000 0.439 0.561
C40-C41 Malignant neoplasms of bone and articular cartilage
0.000 0.441 0.559
H32 Chorioretinal disorders in diseases classified elsewhere
0.000 0.441 0.559
D06.9 Cervix, unspecified
0.000 0.443 0.557
C12 Malignant neoplasm of pyriform sinus
0.000 0.444 0.556
E67 Other hyperalimentation
0.000 0.444 0.556
E68 Sequelae of hyperalimentation
0.000 0.444 0.556
Q51 Congenital malformations of uterus and cervix
0.000 0.445 0.555
E21.2 Other hyperparathyroidism
0.000 0.445 0.555
L57.8 Other skin changes due to chronic exposure to nonionising radiation
0.000 0.446 0.554
G36.9 Acute disseminated demyelination, unspecified
0.552 0.448 0.000
G36.8 Other specified acute disseminated demyelination
0.552 0.448 0.000
G36.1 Acute and subacute haemorrhagic leukoencephalitis [Hurst]
0.552 0.448 0.000
D47.2 Monoclonal gammopathy
0.000 0.452 0.548
H53-H54 Visual disturbances and blindness
0.000 0.452 0.548
Q53 Undescended testicle
0.000 0.453 0.547
E11.1 With ketoacidosis
0.000 0.454 0.546
H30.9 Chorioretinal inflammation, unspecified
0.000 0.456 0.544
E79.9 Disorder of purine and pyrimidine metabolism, unspecified
0.000 0.457 0.543
E79.8 Other disorders of purine and pyrimidine metabolism
0.000 0.457 0.543
E79.1 Lesch-Nyhan syndrome
0.000 0.457 0.543
H50.0 Convergent concomitant strabismus
0.000 0.458 0.542
C84 Peripheral and cutaneous T-cell lymphomas
0.000 0.459 0.541
C88.9 Malignant immunoproliferative disease, unspecified
0.000 0.459 0.541
C88.7 Other malignant immunoproliferative diseases
0.000 0.459 0.541
C88.3 Immunoproliferative small intestinal disease
0.000 0.459 0.541
C88.2 Gamma heavy chain disease
0.000 0.459 0.541
C88.1 Alpha heavy chain disease
0.000 0.459 0.541
H35.1 Retinopathy of prematurity
0.000 0.460 0.540
C91.4 Hairy-cell leukaemia
0.000 0.460 0.540
E72 Other disorders of amino-acid metabolism
0.000 0.461 0.539
D47.9 Neoplasm of uncertain or unknown behaviour of lymphoid, haematopoietic and related tissue, unspecified
0.000 0.462 0.538
C90 Multiple myeloma and malignant plasma cell neoplasms
0.000 0.464 0.536
C83.5 Lymphoblastic (diffuse)
0.000 0.466 0.534
E22.1 Hyperprolactinaemia
0.000 0.468 0.532
D03.5 Melanoma in situ of trunk
0.000 0.470 0.530
Q85.0 Neurofibromatosis (nonmalignant)
0.000 0.471 0.529
Q50 Congenital malformations of ovaries, Fallopian tubes and broad ligaments
0.000 0.472 0.528
E88.9 Metabolic disorder, unspecified
0.000 0.474 0.526
C02 Malignant neoplasm of other and unspecified parts of tongue
0.000 0.475 0.525
D00.1 Oesophagus
0.000 0.476 0.524
Q52 Other congenital malformations of female genitalia
0.000 0.476 0.524
E70.3 Albinism
0.000 0.477 0.523
Q87 Other specified congenital malformation syndromes affecting multiple systems
0.000 0.477 0.523
Q61.5 Medullary cystic kidney
0.000 0.478 0.522
E88.1 Lipodystrophy, not elsewhere classified
0.000 0.478 0.522
E78.8 Other disorders of lipoprotein metabolism
0.000 0.479 0.520
E46 Unspecified protein-energy malnutrition
0.000 0.480 0.520
C81 Hodgkin's disease
0.000 0.480 0.520
H83.3 Noise effects on inner ear
0.000 0.482 0.518
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.483 0.517
E45 Retarded development following protein-energy malnutrition
0.000 0.483 0.517
E43 Unspecified severe protein-energy malnutrition
0.000 0.483 0.517
E42 Marasmic kwashiorkor
0.000 0.483 0.517
E41 Nutritional marasmus
0.000 0.483 0.517
E40 Kwashiorkor
0.000 0.483 0.517
E88.3 Tumour lysis syndrome
0.000 0.483 0.516
M07.38 Other psoriatic arthropathies (Other)
0.000 0.485 0.515
M07.33 Other psoriatic arthropathies (Forearm)
0.000 0.485 0.515
M07.32 Other psoriatic arthropathies (Upper arm)
0.000 0.485 0.515
M07.31 Other psoriatic arthropathies (Shoulder region)
0.000 0.485 0.515
E12.9 Without complications
0.000 0.486 0.514
E12.8 With unspecified complications
0.000 0.486 0.514
E12.7 With multiple complications
0.000 0.486 0.514
E12.6 With other specified complications
0.000 0.486 0.514
E12.5 With peripheral circulatory complications
0.000 0.486 0.514
E12.4 With neurological complications
0.000 0.486 0.514
E12.3 With ophthalmic complications
0.000 0.486 0.514
E12.2 With renal complications
0.000 0.486 0.514
E12.1 With ketoacidosis
0.000 0.486 0.514
E12.0 With coma
0.000 0.486 0.514
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.000 0.486 0.514
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.000 0.486 0.514
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.000 0.486 0.514
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.000 0.486 0.514
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.486 0.514
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.000 0.486 0.514
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.000 0.486 0.514
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.000 0.486 0.514
E30.9 Disorder of puberty, unspecified
0.000 0.488 0.512
E30.8 Other disorders of puberty
0.000 0.488 0.512
E30.1 Precocious puberty
0.000 0.488 0.512
E30.0 Delayed puberty
0.000 0.488 0.512
E31.9 Polyglandular dysfunction, unspecified
0.000 0.488 0.512
E31.8 Other polyglandular dysfunction
0.000 0.488 0.512
E31.1 Polyglandular hyperfunction
0.000 0.488 0.512
E31.0 Autoimmune polyglandular failure
0.000 0.488 0.512
E32.9 Disease of thymus, unspecified
0.000 0.488 0.512
E32.8 Other diseases of thymus
0.000 0.488 0.512
E32.1 Abscess of thymus
0.000 0.488 0.512
E32.0 Persistent hyperplasia of thymus
0.000 0.488 0.512
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.488 0.512
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.488 0.512
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.488 0.512
E07 Other disorders of thyroid
0.000 0.488 0.512
H83.9 Disease of inner ear, unspecified
0.000 0.489 0.511
E21.5 Disorder of parathyroid gland, unspecified
0.000 0.490 0.510
E26.8 Other hyperaldosteronism
0.000 0.490 0.510
E26.1 Secondary hyperaldosteronism
0.000 0.490 0.510
C43.3 Malignant melanoma of other and unspecified parts of face
0.000 0.491 0.509
D43.4 Spinal cord
0.000 0.491 0.509
L57.4 Cutis laxa senilis
0.000 0.493 0.507
E78.3 Hyperchylomicronaemia
0.000 0.493 0.506
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.494 0.506
Q86 Congenital malformation syndromes due to known exogenous causes, not elsewhere classified
0.000 0.494 0.506
Q84 Other congenital malformations of integument
0.000 0.494 0.506
Q81 Epidermolysis bullosa
0.000 0.494 0.506
Q80 Congenital ichthyosis
0.000 0.494 0.506
H35.5 Hereditary retinal dystrophy
0.000 0.496 0.504
C75 Malignant neoplasm of other endocrine glands and related structures
0.000 0.496 0.504
Q51.2 Other doubling of uterus
0.000 0.496 0.504
Q55 Other congenital malformations of male genital organs
0.000 0.496 0.504
H53 Visual disturbances
0.000 0.498 0.502
E88.2 Lipomatosis, not elsewhere classified
0.000 0.501 0.499
H50.8 Other specified strabismus
0.000 0.505 0.495
H35.3 Degeneration of macula and posterior pole
0.000 0.505 0.495
Q30-Q34 Congenital malformations of the respiratory system
0.000 0.505 0.495
Q85.1 Tuberous sclerosis
0.000 0.505 0.495
Q83.8 Other congenital malformations of breast
0.000 0.506 0.494
E70.9 Disorder of aromatic amino-acid metabolism, unspecified
0.000 0.507 0.492
E70.8 Other disorders of aromatic amino-acid metabolism
0.000 0.507 0.492
E70.2 Disorders of tyrosine metabolism
0.000 0.507 0.492
E70.1 Other hyperphenylalaninaemias
0.000 0.507 0.492
E70.0 Classical phenylketonuria
0.000 0.507 0.492
C11 Malignant neoplasm of nasopharynx
0.000 0.508 0.492
L43.8 Other lichen planus
0.000 0.508 0.492
C08 Malignant neoplasm of other and unspecified major salivary glands
0.000 0.508 0.492
D48 Neoplasm of uncertain or unknown behaviour of other and unspecified sites
0.000 0.508 0.492
L56.9 Acute skin change due to ultraviolet radiation, unspecified
0.000 0.509 0.491
D42 Neoplasm of uncertain or unknown behaviour of meninges
0.000 0.511 0.489
Q61.4 Renal dysplasia
0.000 0.511 0.489
D47.1 Chronic myeloproliferative disease
0.000 0.513 0.487
D06.7 Other parts of cervix
0.000 0.513 0.487
D03.2 Melanoma in situ of ear and external auricular canal
0.000 0.514 0.486
H35.4 Peripheral retinal degeneration
0.000 0.515 0.485
D47.3 Essential (haemorrhagic) thrombocythaemia
0.000 0.515 0.485
L40.8 Other psoriasis
0.001 0.515 0.484
E06.4 Drug-induced thyroiditis
0.000 0.516 0.484
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.516 0.484
E06.0 Acute thyroiditis
0.000 0.516 0.484
Q35-Q37 Cleft lip and cleft palate
0.000 0.516 0.483
Q61.8 Other cystic kidney diseases
0.000 0.517 0.483
Q61.1 Polycystic kidney, infantile type
0.000 0.517 0.483
H35.9 Retinal disorder, unspecified
0.000 0.519 0.481
D48.5 Skin
0.000 0.519 0.481
E25.9 Adrenogenital disorder, unspecified
0.000 0.520 0.480
E25.8 Other adrenogenital disorders
0.000 0.520 0.480
D43.9 Central nervous system, unspecified
0.000 0.521 0.479
D43.7 Other parts of central nervous system
0.000 0.521 0.479
D43.3 Cranial nerves
0.000 0.521 0.479
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.521 0.479
E22.8 Other hyperfunction of pituitary gland
0.000 0.521 0.479
D00.2 Stomach
0.000 0.522 0.478
Q56 Indeterminate sex and pseudohermaphroditism
0.000 0.522 0.478
Q00-Q07 Congenital malformations of the nervous system
0.000 0.523 0.477
E34.8 Other specified endocrine disorders
0.000 0.523 0.477
Q89 Other congenital malformations, not elsewhere classified
0.000 0.524 0.476
L12 Pemphigoid
0.000 0.524 0.476
D06.1 Exocervix
0.000 0.524 0.476
C03 Malignant neoplasm of gum
0.000 0.524 0.476
D01.0 Colon
0.000 0.524 0.476
E14 Unspecified diabetes mellitus
0.000 0.524 0.476
L59.8 Other specified disorders of skin and subcutaneous tissue related to radiation
0.000 0.528 0.472
Q64 Other congenital malformations of urinary system
0.000 0.529 0.471
E71.3 Disorders of fatty-acid metabolism
0.000 0.529 0.471
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified
0.000 0.529 0.471
E71.1 Other disorders of branched-chain amino-acid metabolism
0.000 0.529 0.471
E71.0 Maple-syrup-urine disease
0.000 0.529 0.471
E76.9 Disorder of glucosaminoglycan metabolism, unspecified
0.000 0.529 0.471
E76.8 Other disorders of glucosaminoglycan metabolism
0.000 0.529 0.471
E76.3 Mucopolysaccharidosis, unspecified
0.000 0.529 0.471
E76.2 Other mucopolysaccharidoses
0.000 0.529 0.471
E76.1 Mucopolysaccharidosis, type II
0.000 0.529 0.471
E76.0 Mucopolysaccharidosis, type I
0.000 0.529 0.471
E77.9 Disorder of glycoprotein metabolism, unspecified
0.000 0.529 0.471
E77.8 Other disorders of glycoprotein metabolism
0.000 0.529 0.471
E77.1 Defects in glycoprotein degradation
0.000 0.529 0.471
E77.0 Defects in posttranslational modification of lysosomal enzymes
0.000 0.529 0.471
C96.9 Malignant neoplasms of lymphoid, haematopoietic and related tissue, unspecified
0.000 0.529 0.470
C96.8 Histiocytic sarcoma
0.000 0.529 0.470
C96.7 Other specified malignant neoplasms of lymphoid, haematopoietic and related tissue
0.000 0.529 0.470
C96.6 Unifocal Langerhans-cell histiocytosis
0.000 0.529 0.470
C96.5 Multifocal and unisystemic Langerhans-cell histiocytosis
0.000 0.529 0.470
C96.4 Sarcoma of dendritic cells (accessory cells)
0.000 0.529 0.470
C96.3 True histiocytic lymphoma
0.000 0.529 0.470
C96.2 Malignant mast cell tumour
0.000 0.529 0.470
C96.1 Malignant histiocytosis
0.000 0.529 0.470
C96.0 Letterer-Siwe disease
0.000 0.529 0.470
E80.4 Gilbert's syndrome
0.000 0.531 0.469

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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