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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs2621382
log Bayes Factor = 53.5832
Chromosome 6   position 32,760,445  (GRCh37) Explore rs2621382 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E10.9 Without complications
0.000 0.000 1.000
K90.0 Coeliac disease
0.000 0.000 1.000
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
E10-E14 Diabetes mellitus
0.000 0.000 1.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.000 1.000
E10.3 With ophthalmic complications
0.000 0.000 1.000
G35 Multiple sclerosis
1.000 0.000 0.000
E00-E07 Disorders of thyroid gland
0.000 0.000 1.000
L40.5 Arthropathic psoriasis
0.000 0.000 1.000
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.000 1.000
E11 Non-insulin-dependent diabetes mellitus
0.000 0.000 1.000
E05.9 Thyrotoxicosis, unspecified
0.000 0.000 1.000
E11.3 With ophthalmic complications
0.000 0.001 0.999
L40 Psoriasis
0.000 0.007 0.993
G35-G37 Demyelinating diseases of the central nervous system
0.989 0.011 0.000
H36.0 Diabetic retinopathy
0.000 0.012 0.988
G37 Other demyelinating diseases of central nervous system
0.987 0.013 0.000
E20-E35 Disorders of other endocrine glands
0.000 0.014 0.986
E10.1 With ketoacidosis
0.000 0.021 0.979
G37.9 Demyelinating disease of central nervous system, unspecified
0.978 0.022 0.000
L40.9 Psoriasis, unspecified
0.000 0.025 0.975
C44 Other malignant neoplasms of skin
0.000 0.027 0.973
C44.6 Skin of upper limb, including shoulder
0.000 0.029 0.971
E03 Other hypothyroidism
0.000 0.029 0.971
C44.7 Skin of lower limb, including hip
0.000 0.031 0.969
C81-C96 Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissue
0.000 0.033 0.967
E27 Other disorders of adrenal gland
0.000 0.035 0.965
C82 Follicular [nodular] non-Hodgkin's lymphoma
0.000 0.037 0.963
E10.2 With renal complications
0.000 0.037 0.963
C85 Other and unspecified types of non-Hodgkin's lymphoma
0.000 0.037 0.963
E10.5 With peripheral circulatory complications
0.000 0.040 0.960
E03.9 Hypothyroidism, unspecified
0.000 0.042 0.958
C85.9 Non-Hodgkin's lymphoma, unspecified type
0.000 0.043 0.957
E11.9 Without complications
0.000 0.045 0.955
C43-C44 Melanoma and other malignant neoplasms of skin
0.000 0.046 0.954
E27.1 Primary adrenocortical insufficiency
0.000 0.047 0.953
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.047 0.953
D04 Carcinoma in situ of skin
0.000 0.051 0.949
Chapter II Neoplasms
0.000 0.058 0.942
D00-D09 In situ neoplasms
0.000 0.058 0.942
C82.9 Follicular non-Hodgkin's lymphoma, unspecified
0.000 0.060 0.940
C44.3 Skin of other and unspecified parts of face
0.000 0.060 0.940
E10.4 With neurological complications
0.000 0.062 0.938
L57.0 Actinic keratosis
0.000 0.064 0.936
D04.5 Skin of trunk
0.000 0.070 0.930
E16 Other disorders of pancreatic internal secretion
0.000 0.081 0.919
C83 Diffuse non-Hodgkin's lymphoma
0.000 0.083 0.917
G37.8 Other specified demyelinating diseases of central nervous system
0.896 0.104 0.000
C83.3 Large cell (diffuse)
0.000 0.105 0.895
D04.7 Skin of lower limb, including hip
0.000 0.108 0.892
L40-L45 Papulosquamous disorders
0.000 0.111 0.889
D04.3 Skin of other and unspecified parts of face
0.000 0.115 0.885
E23 Hypofunction and other disorders of pituitary gland
0.000 0.126 0.874
L57 Skin changes due to chronic exposure to nonionising radiation
0.000 0.136 0.864
C44.4 Skin of scalp and neck
0.000 0.141 0.859
C82.0 Small cleaved cell, follicular
0.000 0.147 0.853
E16.2 Hypoglycaemia, unspecified
0.000 0.149 0.851
E10.0 With coma
0.000 0.156 0.844
E11.0 With coma
0.000 0.158 0.842
L55-L59 Radiation-related disorders of the skin and subcutaneous tissue
0.000 0.159 0.841
L40.3 Pustulosis palmaris et plantaris
0.000 0.160 0.840
D09 Carcinoma in situ of other and unspecified sites
0.000 0.162 0.838
C91 Lymphoid leukaemia
0.000 0.162 0.838
L40.1 Generalised pustular psoriasis
0.000 0.170 0.830
E70-E90 Metabolic disorders
0.000 0.170 0.830
H36 Retinal disorders in diseases classified elsewhere
0.000 0.170 0.830
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.000 0.172 0.828
Chapter XII Diseases of the skin and subcutaneous tissue
0.000 0.175 0.825
E89.0 Postprocedural hypothyroidism
0.000 0.184 0.816
C82.2 Large cell, follicular
0.000 0.185 0.815
C73-C75 Malignant neoplasms of thyroid and other endocrine glands
0.000 0.188 0.812
E28 Ovarian dysfunction
0.000 0.193 0.807
E23.7 Disorder of pituitary gland, unspecified
0.000 0.195 0.805
M07.39 Other psoriatic arthropathies (Site unspecified)
0.000 0.197 0.803
M07.3 Other psoriatic arthropathies
0.000 0.200 0.800
C88 Malignant immunoproliferative diseases
0.000 0.202 0.798
E24 Cushing's syndrome
0.000 0.203 0.797
G37.3 Acute transverse myelitis in demyelinating disease of central nervous system
0.797 0.203 0.000
C85.1 B-cell lymphoma, unspecified
0.000 0.204 0.796
D04.4 Skin of scalp and neck
0.000 0.205 0.795
E11.5 With peripheral circulatory complications
0.000 0.205 0.795
C82.4 Follicular lymphoma grade IIIb
0.000 0.207 0.793
M07.30 Other psoriatic arthropathies (Multiple sites)
0.000 0.209 0.791
E10.7 With multiple complications
0.000 0.212 0.787
E27.4 Other and unspecified adrenocortical insufficiency
0.000 0.213 0.787
E13 Other specified diabetes mellitus
0.000 0.214 0.786
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.219 0.781
C85.2 Mediastinal (thymic) large B-cell lymphoma
0.000 0.221 0.779
E23.6 Other disorders of pituitary gland
0.000 0.224 0.776
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.000 0.226 0.774
D04.6 Skin of upper limb, including shoulder
0.000 0.227 0.773
G36 Other acute disseminated demyelination
0.769 0.231 0.000
C83.7 Burkitt's tumour
0.000 0.239 0.761
C91.9 Lymphoid leukaemia, unspecified
0.000 0.240 0.760
E10.6 With other specified complications
0.000 0.243 0.757
D09.0 Bladder
0.000 0.244 0.756
C83.9 Diffuse non-Hodgkin's lymphoma, unspecified
0.000 0.245 0.755
L40.4 Guttate psoriasis
0.000 0.247 0.753
C82.1 Mixed small cleaved and large cell, follicular
0.000 0.256 0.744
E16.1 Other hypoglycaemia
0.000 0.259 0.741
D04.9 Skin, unspecified
0.000 0.261 0.739
# Top node
0.000 0.263 0.737
C73 Malignant neoplasm of thyroid gland
0.000 0.267 0.733
D37-D48 Neoplasms of uncertain or unknown behaviour
0.000 0.267 0.733
C82.7 Other types of follicular non-Hodgkin's lymphoma
0.000 0.269 0.731
M07.36 Other psoriatic arthropathies (Lower leg)
0.000 0.269 0.731
D04.2 Skin of ear and external auricular canal
0.000 0.270 0.730
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.000 0.272 0.728
C44.0 Skin of lip
0.000 0.274 0.726
E11.2 With renal complications
0.000 0.275 0.725
E40-E46 Malnutrition
0.000 0.275 0.725
E65-E68 Obesity and other hyperalimentation
0.000 0.279 0.721
E05.5 Thyroid crisis or storm
0.000 0.283 0.717
E05.4 Thyrotoxicosis factitia
0.000 0.283 0.717
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.283 0.717
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.283 0.717
E12 Malnutrition-related diabetes mellitus
0.000 0.283 0.717
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.283 0.717
E00 Congenital iodine-deficiency syndrome
0.000 0.283 0.717
E11.7 With multiple complications
0.000 0.283 0.717
C97-C97 Malignant neoplasms of independent (primary) multiple sites
0.000 0.283 0.717
H30-H36 Disorders of choroid and retina
0.000 0.283 0.717
E27.3 Drug-induced adrenocortical insufficiency
0.000 0.284 0.716
C83.1 Small cleaved cell (diffuse)
0.000 0.284 0.716
L40.2 Acrodermatitis continua
0.000 0.288 0.712
C88.4 Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue [MALT-lymphoma]
0.000 0.289 0.711
D43 Neoplasm of uncertain or unknown behaviour of brain and central nervous system
0.000 0.289 0.711
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.290 0.710
E10.8 With unspecified complications
0.000 0.292 0.708
G37.5 Concentric sclerosis [Balo]
0.707 0.293 0.000
G37.4 Subacute necrotising myelitis
0.707 0.293 0.000
G37.2 Central pontine myelinolysis
0.707 0.293 0.000
G37.1 Central demyelination of corpus callosum
0.707 0.293 0.000
G37.0 Diffuse sclerosis
0.707 0.293 0.000
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.293 0.707
E32 Diseases of thymus
0.000 0.293 0.707
E31 Polyglandular dysfunction
0.000 0.293 0.707
E30 Disorders of puberty, not elsewhere classified
0.000 0.293 0.707
D00 Carcinoma in situ of oral cavity, oesophagus and stomach
0.000 0.299 0.701
E03.1 Congenital hypothyroidism without goitre
0.000 0.301 0.699
D47 Other neoplasms of uncertain or unknown behaviour of lymphoid, haematopoietic and related tissue
0.000 0.301 0.699
C44.8 Overlapping lesion of skin
0.000 0.302 0.698
E03.5 Myxoedema coma
0.000 0.304 0.696
E03.4 Atrophy of thyroid (acquired)
0.000 0.304 0.696
E03.3 Postinfectious hypothyroidism
0.000 0.304 0.696
C91.0 Acute lymphoblastic leukaemia
0.000 0.305 0.695
D06 Carcinoma in situ of cervix uteri
0.000 0.306 0.694
E06 Thyroiditis
0.000 0.307 0.693
C96 Other and unspecified malignant neoplasms of lymphoid, haematopoietic and related tissue
0.000 0.307 0.693
M07.37 Other psoriatic arthropathies (Ankle and foot)
0.000 0.307 0.693
E27.5 Adrenomedullary hyperfunction
0.000 0.308 0.692
E27.0 Other adrenocortical overactivity
0.000 0.308 0.692
E26 Hyperaldosteronism
0.000 0.309 0.691
C82.6 Cutaneous follicle centre lymphoma
0.000 0.309 0.691
C82.5 Diffuse follicle centre lymphoma
0.000 0.309 0.691
C85.0 Lymphosarcoma
0.000 0.310 0.690
H35 Other retinal disorders
0.000 0.310 0.690
E79 Disorders of purine and pyrimidine metabolism
0.000 0.313 0.687
E05.8 Other thyrotoxicosis
0.000 0.313 0.687
E15 Nondiabetic hypoglycaemic coma
0.000 0.317 0.683
D04.1 Skin of eyelid, including canthus
0.000 0.318 0.682
D04.8 Skin of other sites
0.000 0.319 0.681
D04.0 Skin of lip
0.000 0.319 0.681
E89.6 Postprocedural adrenocortical(-medullary) hypofunction
0.000 0.322 0.678
D43.0 Brain, supratentorial
0.000 0.322 0.678
E78.6 Lipoprotein deficiency
0.000 0.328 0.672
E89.3 Postprocedural hypopituitarism
0.000 0.329 0.671
C94 Other leukaemias of specified cell type
0.000 0.329 0.671
E24.2 Drug-induced Cushing's syndrome
0.000 0.330 0.670
E11.8 With unspecified complications
0.000 0.332 0.668
L43 Lichen planus
0.000 0.336 0.664
E25 Adrenogenital disorders
0.000 0.337 0.663
Chapter VII Diseases of the eye and adnexa
0.000 0.340 0.660
C91.5 Adult T-cell leukaemia
0.000 0.340 0.660
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.341 0.659
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.341 0.659
E16.4 Abnormal secretion of gastrin
0.000 0.341 0.659
E16.3 Increased secretion of glucagon
0.000 0.341 0.659
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.341 0.658
C83.6 Undifferentiated (diffuse)
0.000 0.343 0.657
C83.4 Immunoblastic (diffuse)
0.000 0.343 0.657
C83.2 Mixed small and large cell (diffuse)
0.000 0.343 0.657
C43 Malignant melanoma of skin
0.000 0.344 0.656
E29 Testicular dysfunction
0.000 0.347 0.653
E28.2 Polycystic ovarian syndrome
0.000 0.348 0.652
C86 Other specified types of T/NK-cell lymphoma
0.000 0.348 0.651
C93 Monocytic leukaemia
0.000 0.350 0.650
E78.2 Mixed hyperlipidaemia
0.000 0.350 0.650
D02 Carcinoma in situ of middle ear and respiratory system
0.000 0.351 0.649
E22 Hyperfunction of pituitary gland
0.000 0.351 0.649
C00-C14 Malignant neoplasms of lip, oral cavity and pharynx
0.000 0.352 0.648
E89.4 Postprocedural ovarian failure
0.000 0.353 0.646
H35.2 Other proliferative retinopathy
0.000 0.354 0.646
E21.3 Hyperparathyroidism, unspecified
0.000 0.356 0.644
E89.2 Postprocedural hypoparathyroidism
0.000 0.357 0.643
M07.34 Other psoriatic arthropathies (Hand)
0.000 0.357 0.643
E27.2 Addisonian crisis
0.000 0.362 0.638
L44 Other papulosquamous disorders
0.000 0.362 0.637
L45 Papulosquamous disorders in diseases classified elsewhere
0.000 0.362 0.637
H35.8 Other specified retinal disorders
0.000 0.365 0.635
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.000 0.366 0.634
E88 Other metabolic disorders
0.000 0.367 0.633
C85.7 Other specified types of non-Hodgkin's lymphoma
0.000 0.369 0.631
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.000 0.373 0.627
E23.1 Drug-induced hypopituitarism
0.000 0.373 0.627
E65 Localised adiposity
0.000 0.374 0.626
E11.6 With other specified complications
0.000 0.376 0.624
Q80-Q89 Other congenital malformations
0.000 0.379 0.621
E03.8 Other specified hypothyroidism
0.000 0.379 0.621
C44.2 Skin of ear and external auricular canal
0.000 0.379 0.621
C95 Leukaemia of unspecified cell type
0.000 0.379 0.621
D47.2 Monoclonal gammopathy
0.000 0.379 0.621
E28.3 Primary ovarian failure
0.000 0.380 0.620
L57.5 Actinic granuloma
0.000 0.380 0.620
L57.3 Poikiloderma of Civatte
0.000 0.380 0.620
L57.2 Cutis rhomboidalis nuchae
0.000 0.380 0.620
L57.1 Actinic reticuloid
0.000 0.380 0.620
L41 Parapsoriasis
0.000 0.381 0.619
E27.8 Other specified disorders of adrenal gland
0.000 0.382 0.618
D09.9 Carcinoma in situ, unspecified
0.000 0.383 0.616
L59 Other disorders of skin and subcutaneous tissue related to radiation
0.000 0.384 0.616
D43.2 Brain, unspecified
0.000 0.384 0.616
E24.0 Pituitary-dependent Cushing's disease
0.000 0.384 0.616
E89.8 Other postprocedural endocrine and metabolic disorders
0.000 0.386 0.614
E27.9 Disorder of adrenal gland, unspecified
0.000 0.386 0.614
E13.3 With ophthalmic complications
0.000 0.387 0.612
D03 Melanoma in situ
0.000 0.388 0.612
G36.0 Neuromyelitis optica [Devic]
0.611 0.389 0.000
D47.9 Neoplasm of uncertain or unknown behaviour of lymphoid, haematopoietic and related tissue, unspecified
0.000 0.389 0.611
E78.5 Hyperlipidaemia, unspecified
0.000 0.390 0.610
D09.1 Other and unspecified urinary organs
0.000 0.390 0.609
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.000 0.390 0.609
C82.3 Follicular lymphoma grade IIIa
0.000 0.391 0.609
Q85 Phakomatoses, not elsewhere classified
0.000 0.391 0.609
E70 Disorders of aromatic amino-acid metabolism
0.000 0.392 0.608
E06.3 Autoimmune thyroiditis
0.000 0.394 0.606
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.397 0.603
L55 Sunburn
0.000 0.397 0.603
C74 Malignant neoplasm of adrenal gland
0.000 0.398 0.602
L56 Other acute skin changes due to ultraviolet radiation
0.000 0.398 0.602
C83.5 Lymphoblastic (diffuse)
0.000 0.398 0.601
D09.7 Carcinoma in situ of other specified sites
0.000 0.399 0.601
D09.3 Thyroid and other endocrine glands
0.000 0.399 0.601
D09.2 Eye
0.000 0.399 0.601
C91.8 Mature B-cell leukaemia Burkitt-type
0.000 0.399 0.601
C91.7 Other lymphoid leukaemia
0.000 0.399 0.601
C91.6 Prolymphocytic leukaemia of T-cell type
0.000 0.399 0.601
C91.3 Prolymphocytic leukaemia
0.000 0.399 0.601
C91.2 Subacute lymphocytic leukaemia
0.000 0.399 0.601
C43.3 Malignant melanoma of other and unspecified parts of face
0.000 0.402 0.598
H83.0 Labyrinthitis
0.000 0.404 0.596
E77 Disorders of glycoprotein metabolism
0.000 0.404 0.595
E76 Disorders of glycosaminoglycan metabolism
0.000 0.404 0.595
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.000 0.404 0.595
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.000 0.404 0.595
H36.8 Other retinal disorders in diseases classified elsewhere
0.000 0.405 0.595
E20 Hypoparathyroidism
0.000 0.405 0.595
E89.9 Postprocedural endocrine and metabolic disorder, unspecified
0.000 0.407 0.593
E89.5 Postprocedural testicular hypofunction
0.000 0.407 0.593
E84 Cystic fibrosis
0.000 0.408 0.592
H83 Other diseases of inner ear
0.000 0.408 0.591
H30 Chorioretinal inflammation
0.000 0.409 0.591
Chapter VIII Diseases of the ear and mastoid process
0.000 0.409 0.591
L40.0 Psoriasis vulgaris
0.000 0.410 0.590
L10-L14 Bullous disorders
0.000 0.411 0.589
E21.4 Other specified disorders of parathyroid gland
0.000 0.411 0.589
E13.9 Without complications
0.000 0.412 0.588
H35.6 Retinal haemorrhage
0.000 0.413 0.587
L42 Pityriasis rosea
0.000 0.415 0.585
H80-H83 Diseases of inner ear
0.000 0.415 0.585
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
0.000 0.415 0.585
C40-C41 Malignant neoplasms of bone and articular cartilage
0.000 0.416 0.584
D01 Carcinoma in situ of other and unspecified digestive organs
0.000 0.416 0.584
E85 Amyloidosis
0.000 0.417 0.583
L57.9 Skin changes due to chronic exposure to nonionising radiation, unspecified
0.000 0.418 0.582
Q50-Q56 Congenital malformations of genital organs
0.000 0.420 0.580
C12 Malignant neoplasm of pyriform sinus
0.000 0.420 0.580
Q60-Q64 Congenital malformations of the urinary system
0.000 0.421 0.579
E28.9 Ovarian dysfunction, unspecified
0.000 0.421 0.579
E28.8 Other ovarian dysfunction
0.000 0.421 0.579
E28.1 Androgen excess
0.000 0.421 0.579
E28.0 Oestrogen excess
0.000 0.421 0.579
E07 Other disorders of thyroid
0.000 0.422 0.578
C84 Peripheral and cutaneous T-cell lymphomas
0.000 0.424 0.575
Q85.8 Other phakomatoses, not elsewhere classified
0.000 0.425 0.575
M07.38 Other psoriatic arthropathies (Other)
0.000 0.426 0.574
M07.33 Other psoriatic arthropathies (Forearm)
0.000 0.426 0.574
M07.32 Other psoriatic arthropathies (Upper arm)
0.000 0.426 0.574
M07.31 Other psoriatic arthropathies (Shoulder region)
0.000 0.426 0.574
C88.9 Malignant immunoproliferative disease, unspecified
0.000 0.427 0.572
C88.7 Other malignant immunoproliferative diseases
0.000 0.427 0.572
C88.3 Immunoproliferative small intestinal disease
0.000 0.427 0.572
C88.2 Gamma heavy chain disease
0.000 0.427 0.572
C88.1 Alpha heavy chain disease
0.000 0.427 0.572
E24.8 Other Cushing's syndrome
0.000 0.428 0.572
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.000 0.428 0.572
E24.3 Ectopic ACTH syndrome
0.000 0.428 0.572
E24.1 Nelson's syndrome
0.000 0.428 0.572
E80 Disorders of porphyrin and bilirubin metabolism
0.000 0.431 0.569
L58 Radiodermatitis
0.000 0.431 0.569
Q61 Cystic kidney disease
0.000 0.432 0.568
L57.8 Other skin changes due to chronic exposure to nonionising radiation
0.000 0.433 0.567
D00.1 Oesophagus
0.000 0.434 0.566
E21.2 Other hyperparathyroidism
0.000 0.436 0.564
E13.8 With unspecified complications
0.000 0.437 0.563
E13.7 With multiple complications
0.000 0.437 0.563
E13.6 With other specified complications
0.000 0.437 0.563
E13.5 With peripheral circulatory complications
0.000 0.437 0.563
E13.4 With neurological complications
0.000 0.437 0.563
E13.2 With renal complications
0.000 0.437 0.563
E13.1 With ketoacidosis
0.000 0.437 0.563
E13.0 With coma
0.000 0.437 0.563
D47.1 Chronic myeloproliferative disease
0.000 0.439 0.561
E89.1 Postprocedural hypoinsulinaemia
0.000 0.440 0.560
D06.9 Cervix, unspecified
0.000 0.442 0.558
C97 Malignant neoplasms of independent (primary) multiple sites
0.000 0.445 0.555
E26.9 Hyperaldosteronism, unspecified
0.000 0.445 0.555
G36.9 Acute disseminated demyelination, unspecified
0.551 0.448 0.000
G36.8 Other specified acute disseminated demyelination
0.551 0.448 0.000
G36.1 Acute and subacute haemorrhagic leukoencephalitis [Hurst]
0.551 0.448 0.000
E78.1 Pure hyperglyceridaemia
0.000 0.449 0.551
C91.4 Hairy-cell leukaemia
0.000 0.450 0.550
C02 Malignant neoplasm of other and unspecified parts of tongue
0.000 0.450 0.550
Q85.9 Phakomatosis, unspecified
0.000 0.455 0.545
E34 Other endocrine disorders
0.000 0.456 0.543
C81 Hodgkin's disease
0.000 0.456 0.543
D47.3 Essential (haemorrhagic) thrombocythaemia
0.000 0.459 0.541
H35.0 Background retinopathy and retinal vascular changes
0.000 0.460 0.540
D43.4 Spinal cord
0.000 0.461 0.539
Chapter XVI Certain conditions originating in the perinatal period
0.000 0.467 0.533
C43.6 Malignant melanoma of upper limb, including shoulder
0.000 0.467 0.533
D03.5 Melanoma in situ of trunk
0.000 0.468 0.532
E46 Unspecified protein-energy malnutrition
0.000 0.473 0.527
E88.8 Other specified metabolic disorders
0.000 0.474 0.526
D42 Neoplasm of uncertain or unknown behaviour of meninges
0.000 0.475 0.525
C90 Multiple myeloma and malignant plasma cell neoplasms
0.000 0.476 0.524
Q61.3 Polycystic kidney, unspecified
0.000 0.478 0.522
E83.1 Disorders of iron metabolism
0.521 0.478 0.001
E11.1 With ketoacidosis
0.000 0.479 0.521
E73 Lactose intolerance
0.000 0.480 0.520
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.480 0.519
E45 Retarded development following protein-energy malnutrition
0.000 0.480 0.519
E43 Unspecified severe protein-energy malnutrition
0.000 0.480 0.519
E42 Marasmic kwashiorkor
0.000 0.480 0.519
E41 Nutritional marasmus
0.000 0.480 0.519
E40 Kwashiorkor
0.000 0.480 0.519
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.000 0.480 0.519
E14 Unspecified diabetes mellitus
0.000 0.481 0.519
E21.5 Disorder of parathyroid gland, unspecified
0.000 0.481 0.518
E22.1 Hyperprolactinaemia
0.000 0.482 0.518
E67 Other hyperalimentation
0.000 0.483 0.517
E68 Sequelae of hyperalimentation
0.000 0.483 0.517
C43.2 Malignant melanoma of ear and external auricular canal
0.000 0.483 0.517
E12.9 Without complications
0.000 0.486 0.514
E12.8 With unspecified complications
0.000 0.486 0.514
E12.7 With multiple complications
0.000 0.486 0.514
E12.6 With other specified complications
0.000 0.486 0.514
E12.5 With peripheral circulatory complications
0.000 0.486 0.514
E12.4 With neurological complications
0.000 0.486 0.514
E12.3 With ophthalmic complications
0.000 0.486 0.514
E12.2 With renal complications
0.000 0.486 0.514
E12.1 With ketoacidosis
0.000 0.486 0.514
E12.0 With coma
0.000 0.486 0.514
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.000 0.486 0.514
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.000 0.486 0.514
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.000 0.486 0.514
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.000 0.486 0.514
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.486 0.514
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.000 0.486 0.514
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.000 0.486 0.514
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.000 0.486 0.514
H32 Chorioretinal disorders in diseases classified elsewhere
0.000 0.486 0.514
D46 Myelodysplastic syndromes
0.000 0.486 0.514
C75 Malignant neoplasm of other endocrine glands and related structures
0.000 0.487 0.513
C11 Malignant neoplasm of nasopharynx
0.000 0.487 0.513
C08 Malignant neoplasm of other and unspecified major salivary glands
0.000 0.487 0.513
Q61.0 Congenital single renal cyst
0.000 0.487 0.513
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.489 0.511
Q83 Congenital malformations of breast
0.000 0.489 0.511
D43.9 Central nervous system, unspecified
0.000 0.490 0.509
D43.7 Other parts of central nervous system
0.000 0.490 0.509
D43.3 Cranial nerves
0.000 0.490 0.509
L43.8 Other lichen planus
0.000 0.491 0.509
H49-H52 Disorders of ocular muscles, binocular movement, accommodation and refraction
0.000 0.492 0.508
E30.9 Disorder of puberty, unspecified
0.000 0.493 0.507
E30.8 Other disorders of puberty
0.000 0.493 0.507
E30.1 Precocious puberty
0.000 0.493 0.507
E30.0 Delayed puberty
0.000 0.493 0.507
E31.9 Polyglandular dysfunction, unspecified
0.000 0.493 0.507
E31.8 Other polyglandular dysfunction
0.000 0.493 0.507
E31.1 Polyglandular hyperfunction
0.000 0.493 0.507
E31.0 Autoimmune polyglandular failure
0.000 0.493 0.507
E32.9 Disease of thymus, unspecified
0.000 0.493 0.507
E32.8 Other diseases of thymus
0.000 0.493 0.507
E32.1 Abscess of thymus
0.000 0.493 0.507
E32.0 Persistent hyperplasia of thymus
0.000 0.493 0.507
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.493 0.507
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.493 0.507
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.493 0.507
D00.2 Stomach
0.000 0.497 0.503
D45 Polycythaemia vera
0.000 0.498 0.502
D47.7 Other specified neoplasms of uncertain or unknown behaviour of lymphoid, haematopoietic and related tissue
0.000 0.499 0.501
D47.5 Chronic eosinophilic leukaemia [hypereosinophilic syndrome]
0.000 0.499 0.501
D47.0 Histiocytic and mast cell tumours of uncertain and unknown behaviour
0.000 0.499 0.501
H30.9 Chorioretinal inflammation, unspecified
0.000 0.499 0.501
E24.9 Cushing's syndrome, unspecified
0.000 0.499 0.501
D06.7 Other parts of cervix
0.000 0.502 0.497
E06.4 Drug-induced thyroiditis
0.000 0.503 0.497
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.503 0.497
E06.0 Acute thyroiditis
0.000 0.503 0.497
C96.9 Malignant neoplasms of lymphoid, haematopoietic and related tissue, unspecified
0.000 0.503 0.497
C96.8 Histiocytic sarcoma
0.000 0.503 0.497
C96.7 Other specified malignant neoplasms of lymphoid, haematopoietic and related tissue
0.000 0.503 0.497
C96.6 Unifocal Langerhans-cell histiocytosis
0.000 0.503 0.497
C96.5 Multifocal and unisystemic Langerhans-cell histiocytosis
0.000 0.503 0.497
C96.4 Sarcoma of dendritic cells (accessory cells)
0.000 0.503 0.497
C96.3 True histiocytic lymphoma
0.000 0.503 0.497
C96.2 Malignant mast cell tumour
0.000 0.503 0.497
C96.1 Malignant histiocytosis
0.000 0.503 0.497
C96.0 Letterer-Siwe disease
0.000 0.503 0.497
D03.2 Melanoma in situ of ear and external auricular canal
0.000 0.504 0.496
C03 Malignant neoplasm of gum
0.000 0.504 0.496
E26.8 Other hyperaldosteronism
0.000 0.504 0.495
E26.1 Secondary hyperaldosteronism
0.000 0.504 0.495
Q61.9 Cystic kidney disease, unspecified
0.000 0.505 0.495
H35.1 Retinopathy of prematurity
0.000 0.505 0.494
E79.9 Disorder of purine and pyrimidine metabolism, unspecified
0.000 0.507 0.493
E79.8 Other disorders of purine and pyrimidine metabolism
0.000 0.507 0.493
E79.1 Lesch-Nyhan syndrome
0.000 0.507 0.493
L57.4 Cutis laxa senilis
0.000 0.508 0.492
E78.9 Disorder of lipoprotein metabolism, unspecified
0.000 0.510 0.490
E72 Other disorders of amino-acid metabolism
0.000 0.511 0.489
H50 Other strabismus
0.000 0.513 0.487
D06.1 Exocervix
0.000 0.513 0.487
Q51 Congenital malformations of uterus and cervix
0.000 0.514 0.486
C88.0 Waldenstrom's macroglobulinaemia
0.000 0.515 0.485
H35.3 Degeneration of macula and posterior pole
0.000 0.516 0.484
E78.8 Other disorders of lipoprotein metabolism
0.000 0.516 0.484
E06.5 Other chronic thyroiditis
0.000 0.518 0.482
C02.9 Tongue, unspecified
0.000 0.518 0.482
L40.8 Other psoriasis
0.001 0.518 0.481
C94.7 Other specified leukaemias
0.000 0.519 0.481
C94.5 Acute myelofibrosis
0.000 0.519 0.481
C94.4 Acute panmyelosis
0.000 0.519 0.481
C94.3 Mast cell leukaemia
0.000 0.519 0.481
C94.2 Acute megakaryoblastic leukaemia
0.000 0.519 0.481
C94.1 Chronic erythraemia
0.000 0.519 0.481
C94.0 Acute erythraemia and erythroleukaemia
0.000 0.519 0.481
M07.35 Other psoriatic arthropathies (Pelvic region and thigh)
0.000 0.520 0.480
Q85.0 Neurofibromatosis (nonmalignant)
0.000 0.520 0.480
D40 Neoplasm of uncertain or unknown behaviour of male genital organs
0.000 0.521 0.479
H83.3 Noise effects on inner ear
0.000 0.523 0.477
Q53 Undescended testicle
0.000 0.523 0.477
L43.3 Subacute (active) lichen planus
0.000 0.524 0.476
L43.2 Lichenoid drug reaction
0.000 0.524 0.476
L43.1 Bullous lichen planus
0.000 0.524 0.476
L43.0 Hypertrophic lichen planus
0.000 0.524 0.476
C40 Malignant neoplasm of bone and articular cartilage of limbs
0.000 0.524 0.476
E25.9 Adrenogenital disorder, unspecified
0.000 0.524 0.475
E25.8 Other adrenogenital disorders
0.000 0.524 0.475
L56.9 Acute skin change due to ultraviolet radiation, unspecified
0.000 0.525 0.475
H53-H54 Visual disturbances and blindness
0.000 0.528 0.472
E88.9 Metabolic disorder, unspecified
0.000 0.528 0.471
H83.9 Disease of inner ear, unspecified
0.000 0.528 0.471
C14 Malignant neoplasm of other and ill-defined sites in the lip, oral cavity and pharynx
0.000 0.529 0.471
H50.0 Convergent concomitant strabismus
0.000 0.529 0.471
D43.1 Brain, infratentorial
0.000 0.529 0.471
C43.8 Overlapping malignant melanoma of skin
0.000 0.530 0.470
C43.0 Malignant melanoma of lip
0.000 0.530 0.470
E88.1 Lipodystrophy, not elsewhere classified
0.000 0.532 0.468
E29.8 Other testicular dysfunction
0.000 0.532 0.468
E29.0 Testicular hyperfunction
0.000 0.532 0.468
L43.9 Lichen planus, unspecified
0.000 0.532 0.468
C95.0 Acute leukaemia of unspecified cell type
0.000 0.532 0.467
C86.6 Primary cutaneous CD30-positive T-cell proliferations
0.000 0.533 0.467
C86.4 Blastic NK-cell lymphoma
0.000 0.533 0.467
C86.3 Subcutaneous panniculitis-like T-cell lymphoma
0.000 0.533 0.467
C86.2 Enteropathy-type (intestinal) T-cell lymphoma
0.000 0.533 0.467
C86.1 Hepatosplenic T-cell lymphoma
0.000 0.533 0.467
C86.0 Extranodal NK/T-cell lymphoma, nasal type
0.000 0.533 0.467
C93.9 Monocytic leukaemia, unspecified
0.000 0.534 0.466
C93.7 Other monocytic leukaemia
0.000 0.534 0.466
C93.3 Juvenile myelomonocytic leukaemia
0.000 0.534 0.466
C93.2 Subacute monocytic leukaemia
0.000 0.534 0.466
C93.0 Acute monocytic leukaemia
0.000 0.534 0.466
D02.4 Respiratory system, unspecified
0.000 0.534 0.466
D02.3 Other parts of respiratory system
0.000 0.534 0.466
D02.2 Bronchus and lung
0.000 0.534 0.466
D02.1 Trachea
0.000 0.534 0.466
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.535 0.465
E22.8 Other hyperfunction of pituitary gland
0.000 0.535 0.465
C81.1 Nodular sclerosis
0.000 0.535 0.465
Q87 Other specified congenital malformation syndromes affecting multiple systems
0.000 0.536 0.464
H35.5 Hereditary retinal dystrophy
0.000 0.536 0.464
E88.3 Tumour lysis syndrome
0.000 0.537 0.463
C02.2 Ventral surface of tongue
0.000 0.537 0.463
D01.0 Colon
0.000 0.537 0.462
D48 Neoplasm of uncertain or unknown behaviour of other and unspecified sites
0.000 0.539 0.461
C43.7 Malignant melanoma of lower limb, including hip
0.000 0.539 0.461

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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