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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs2621387
log Bayes Factor = 80.6034
Chromosome 6   position 32,757,971  (GRCh37) Explore rs2621387 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)
0.000 0.000 1.000
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)
0.000 0.000 1.000
E03.9 Hypothyroidism, unspecified
0.000 0.000 1.000
E10.9 Without complications
0.000 0.000 1.000
M06.9 Rheumatoid arthritis, unspecified
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
G35 Multiple sclerosis
1.000 0.000 0.000
M06 Other rheumatoid arthritis
0.000 0.000 1.000
E10-E14 Diabetes mellitus
0.000 0.000 1.000
E00-E07 Disorders of thyroid gland
0.000 0.000 1.000
M05-M14 Inflammatory polyarthropathies
0.000 0.000 1.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.000 1.000
M05.9 Seropositive rheumatoid arthritis, unspecified
0.000 0.000 1.000
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.000 1.000
E11 Non-insulin-dependent diabetes mellitus
0.000 0.000 1.000
M05 Seropositive rheumatoid arthritis
0.000 0.000 1.000
E10.3 With ophthalmic complications
0.000 0.000 1.000
E03 Other hypothyroidism
0.000 0.000 1.000
M07.3 Other psoriatic arthropathies
0.000 0.000 1.000
M07 Psoriatic and enteropathic arthropathies
0.000 0.000 1.000
E05.9 Thyrotoxicosis, unspecified
0.000 0.000 1.000
K90.0 Coeliac disease
0.000 0.000 1.000
M05.90 Seropositive rheumatoid arthritis, unspecified (Multiple sites)
0.000 0.000 1.000
D04 Carcinoma in situ of skin
0.000 0.001 0.999
D00-D09 In situ neoplasms
0.000 0.001 0.999
E11.3 With ophthalmic complications
0.000 0.001 0.999
E11.9 Without complications
0.000 0.002 0.998
M07.39 Other psoriatic arthropathies (Site unspecified)
0.000 0.002 0.998
G35-G37 Demyelinating diseases of the central nervous system
0.997 0.003 0.000
G37 Other demyelinating diseases of central nervous system
0.997 0.003 0.000
M05.99 Seropositive rheumatoid arthritis, unspecified (Site unspecified)
0.000 0.003 0.997
G37.9 Demyelinating disease of central nervous system, unspecified
0.995 0.005 0.000
M06.94 Rheumatoid arthritis, unspecified (Hand)
0.000 0.005 0.995
C81-C96 Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissue
0.000 0.005 0.995
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.006 0.994
C44 Other malignant neoplasms of skin
0.000 0.007 0.993
C43-C44 Melanoma and other malignant neoplasms of skin
0.000 0.007 0.993
C85 Other and unspecified types of non-Hodgkin's lymphoma
0.000 0.007 0.993
Chapter II Neoplasms
0.000 0.008 0.992
C85.9 Non-Hodgkin's lymphoma, unspecified type
0.000 0.009 0.991
C44.7 Skin of lower limb, including hip
0.000 0.010 0.990
L57.0 Actinic keratosis
0.000 0.010 0.990
E70-E90 Metabolic disorders
0.000 0.016 0.984
C44.6 Skin of upper limb, including shoulder
0.000 0.018 0.982
D04.7 Skin of lower limb, including hip
0.000 0.021 0.979
C82 Follicular [nodular] non-Hodgkin's lymphoma
0.000 0.021 0.979
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.000 0.021 0.979
D04.5 Skin of trunk
0.000 0.022 0.978
D06 Carcinoma in situ of cervix uteri
0.000 0.025 0.975
C83 Diffuse non-Hodgkin's lymphoma
0.000 0.026 0.974
M07.30 Other psoriatic arthropathies (Multiple sites)
0.000 0.027 0.973
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.000 0.030 0.970
L40.5 Arthropathic psoriasis
0.000 0.032 0.968
C83.3 Large cell (diffuse)
0.000 0.032 0.968
E10.1 With ketoacidosis
0.000 0.035 0.965
E89.0 Postprocedural hypothyroidism
0.000 0.037 0.963
E20-E35 Disorders of other endocrine glands
0.000 0.038 0.962
D06.9 Cervix, unspecified
0.000 0.044 0.956
M06.0 Seronegative rheumatoid arthritis
0.000 0.045 0.955
L40 Psoriasis
0.000 0.048 0.952
M06.96 Rheumatoid arthritis, unspecified (Lower leg)
0.000 0.049 0.951
H36.0 Diabetic retinopathy
0.000 0.053 0.947
E27 Other disorders of adrenal gland
0.000 0.058 0.942
C44.3 Skin of other and unspecified parts of face
0.000 0.063 0.937
E78.0 Pure hypercholesterolaemia
0.000 0.064 0.936
E83.1 Disorders of iron metabolism
0.934 0.066 0.000
E10.5 With peripheral circulatory complications
0.000 0.066 0.934
E27.1 Primary adrenocortical insufficiency
0.000 0.069 0.931
D04.3 Skin of other and unspecified parts of face
0.000 0.071 0.929
L40.9 Psoriasis, unspecified
0.000 0.076 0.924
C82.9 Follicular non-Hodgkin's lymphoma, unspecified
0.000 0.077 0.923
D09 Carcinoma in situ of other and unspecified sites
0.000 0.085 0.915
M06.3 Rheumatoid nodule
0.000 0.086 0.914
M06.97 Rheumatoid arthritis, unspecified (Ankle and foot)
0.000 0.086 0.914
M06.09 Seronegative rheumatoid arthritis (Site unspecified)
0.000 0.089 0.911
E10.0 With coma
0.000 0.111 0.889
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.113 0.887
L40-L45 Papulosquamous disorders
0.000 0.117 0.883
L57 Skin changes due to chronic exposure to nonionising radiation
0.000 0.119 0.881
M07.36 Other psoriatic arthropathies (Lower leg)
0.000 0.123 0.877
D04.4 Skin of scalp and neck
0.000 0.124 0.876
M06.92 Rheumatoid arthritis, unspecified (Upper arm)
0.000 0.131 0.869
E23 Hypofunction and other disorders of pituitary gland
0.000 0.132 0.868
E10.2 With renal complications
0.000 0.132 0.868
E10.4 With neurological complications
0.000 0.135 0.864
G37.8 Other specified demyelinating diseases of central nervous system
0.861 0.139 0.000
E78.6 Lipoprotein deficiency
0.000 0.140 0.860
C85.1 B-cell lymphoma, unspecified
0.000 0.141 0.859
C91 Lymphoid leukaemia
0.000 0.141 0.859
C43 Malignant melanoma of skin
0.000 0.145 0.855
D03 Melanoma in situ
0.000 0.146 0.854
G37.3 Acute transverse myelitis in demyelinating disease of central nervous system
0.853 0.147 0.000
C82.0 Small cleaved cell, follicular
0.000 0.150 0.850
L55-L59 Radiation-related disorders of the skin and subcutaneous tissue
0.000 0.160 0.840
C82.2 Large cell, follicular
0.000 0.160 0.840
D09.0 Bladder
0.000 0.163 0.837
E10.8 With unspecified complications
0.000 0.165 0.835
E11.5 With peripheral circulatory complications
0.000 0.166 0.834
C73-C75 Malignant neoplasms of thyroid and other endocrine glands
0.000 0.167 0.833
M07.37 Other psoriatic arthropathies (Ankle and foot)
0.000 0.168 0.832
M06.98 Rheumatoid arthritis, unspecified (Other)
0.000 0.170 0.830
M06.93 Rheumatoid arthritis, unspecified (Forearm)
0.000 0.174 0.826
M06.00 Seronegative rheumatoid arthritis (Multiple sites)
0.000 0.176 0.824
E06 Thyroiditis
0.000 0.176 0.824
E78.9 Disorder of lipoprotein metabolism, unspecified
0.000 0.179 0.821
D00 Carcinoma in situ of oral cavity, oesophagus and stomach
0.000 0.182 0.818
D04.9 Skin, unspecified
0.000 0.184 0.816
Chapter XII Diseases of the skin and subcutaneous tissue
0.000 0.187 0.813
E89.3 Postprocedural hypopituitarism
0.000 0.189 0.811
E16 Other disorders of pancreatic internal secretion
0.000 0.194 0.806
E10.6 With other specified complications
0.000 0.200 0.800
E78.2 Mixed hyperlipidaemia
0.000 0.200 0.800
E88 Other metabolic disorders
0.000 0.201 0.799
E11.1 With ketoacidosis
0.000 0.203 0.797
C44.4 Skin of scalp and neck
0.000 0.204 0.796
E79 Disorders of purine and pyrimidine metabolism
0.000 0.211 0.789
E89.2 Postprocedural hypoparathyroidism
0.000 0.213 0.787
M05.97 Seropositive rheumatoid arthritis, unspecified (Ankle and foot)
0.000 0.214 0.786
E89.4 Postprocedural ovarian failure
0.000 0.215 0.785
H36 Retinal disorders in diseases classified elsewhere
0.000 0.217 0.783
E11.0 With coma
0.000 0.217 0.783
C43.3 Malignant melanoma of other and unspecified parts of face
0.000 0.220 0.780
E23.7 Disorder of pituitary gland, unspecified
0.000 0.223 0.777
E28 Ovarian dysfunction
0.000 0.223 0.777
C44.0 Skin of lip
0.000 0.227 0.773
G36 Other acute disseminated demyelination
0.770 0.230 0.000
L40.1 Generalised pustular psoriasis
0.000 0.231 0.769
C83.9 Diffuse non-Hodgkin's lymphoma, unspecified
0.000 0.232 0.768
E06.3 Autoimmune thyroiditis
0.000 0.232 0.768
M07.34 Other psoriatic arthropathies (Hand)
0.000 0.234 0.766
D02 Carcinoma in situ of middle ear and respiratory system
0.000 0.236 0.764
C83.1 Small cleaved cell (diffuse)
0.000 0.236 0.764
D07 Carcinoma in situ of other and unspecified genital organs
0.000 0.238 0.762
E78.1 Pure hyperglyceridaemia
0.000 0.242 0.757
E23.6 Other disorders of pituitary gland
0.000 0.243 0.757
D03.5 Melanoma in situ of trunk
0.000 0.244 0.756
C73 Malignant neoplasm of thyroid gland
0.000 0.245 0.755
E13 Other specified diabetes mellitus
0.000 0.245 0.755
C82.7 Other types of follicular non-Hodgkin's lymphoma
0.000 0.246 0.754
C91.9 Lymphoid leukaemia, unspecified
0.000 0.246 0.754
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.000 0.247 0.753
C00-C14 Malignant neoplasms of lip, oral cavity and pharynx
0.000 0.247 0.753
M06.34 Rheumatoid nodule (Hand)
0.000 0.248 0.752
D04.2 Skin of ear and external auricular canal
0.000 0.249 0.751
E89.6 Postprocedural adrenocortical(-medullary) hypofunction
0.000 0.250 0.750
M06.32 Rheumatoid nodule (Upper arm)
0.000 0.251 0.749
M05.96 Seropositive rheumatoid arthritis, unspecified (Lower leg)
0.000 0.251 0.748
E27.4 Other and unspecified adrenocortical insufficiency
0.000 0.254 0.746
C43.6 Malignant melanoma of upper limb, including shoulder
0.000 0.260 0.740
D01 Carcinoma in situ of other and unspecified digestive organs
0.000 0.261 0.739
M10 Gout
0.000 0.262 0.738
M06.4 Inflammatory polyarthropathy
0.000 0.263 0.737
C83.7 Burkitt's tumour
0.000 0.264 0.736
E70 Disorders of aromatic amino-acid metabolism
0.000 0.269 0.731
E78.5 Hyperlipidaemia, unspecified
0.000 0.270 0.730
C82.1 Mixed small cleaved and large cell, follicular
0.000 0.271 0.729
M06.8 Other specified rheumatoid arthritis
0.000 0.271 0.729
E05.8 Other thyrotoxicosis
0.000 0.271 0.728
M06.07 Seronegative rheumatoid arthritis (Ankle and foot)
0.000 0.274 0.726
M05.92 Seropositive rheumatoid arthritis, unspecified (Upper arm)
0.000 0.277 0.723
E84 Cystic fibrosis
0.000 0.277 0.723
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.279 0.721
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.000 0.280 0.720
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.283 0.717
E10.7 With multiple complications
0.000 0.283 0.717
M06.2 Rheumatoid bursitis
0.000 0.283 0.717
M06.1 Adult-onset Still's disease
0.000 0.283 0.717
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.283 0.717
E00 Congenital iodine-deficiency syndrome
0.000 0.283 0.717
E12 Malnutrition-related diabetes mellitus
0.000 0.283 0.717
M09 Juvenile arthritis in diseases classified elsewhere
0.000 0.283 0.717
M08 Juvenile arthritis
0.000 0.283 0.717
M05.98 Seropositive rheumatoid arthritis, unspecified (Other)
0.000 0.283 0.717
M05.95 Seropositive rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.000 0.283 0.717
M05.94 Seropositive rheumatoid arthritis, unspecified (Hand)
0.000 0.283 0.717
M05.93 Seropositive rheumatoid arthritis, unspecified (Forearm)
0.000 0.283 0.717
E05.5 Thyroid crisis or storm
0.000 0.283 0.717
E05.4 Thyrotoxicosis factitia
0.000 0.283 0.717
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.283 0.717
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.283 0.717
E11.7 With multiple complications
0.000 0.283 0.717
M05.8 Other seropositive rheumatoid arthritis
0.000 0.283 0.717
M05.3 Rheumatoid arthritis with involvement of other organs and systems
0.000 0.283 0.717
M05.1 Rheumatoid lung disease
0.000 0.283 0.717
M05.0 Felty's syndrome
0.000 0.283 0.717
E03.5 Myxoedema coma
0.000 0.283 0.717
E03.4 Atrophy of thyroid (acquired)
0.000 0.283 0.717
E03.3 Postinfectious hypothyroidism
0.000 0.283 0.717
M07.38 Other psoriatic arthropathies (Other)
0.000 0.283 0.717
M07.33 Other psoriatic arthropathies (Forearm)
0.000 0.283 0.717
M07.32 Other psoriatic arthropathies (Upper arm)
0.000 0.283 0.717
M07.31 Other psoriatic arthropathies (Shoulder region)
0.000 0.283 0.717
M07.6 Other enteropathic arthropathies
0.000 0.283 0.717
M07.5 Arthropathy in ulcerative colitis
0.000 0.283 0.717
M07.4 Arthropathy in Crohn's disease [regional enteritis]
0.000 0.283 0.717
M07.2 Psoriatic spondylitis
0.000 0.283 0.717
M07.1 Arthritis mutilans
0.000 0.283 0.717
M07.0 Distal interphalangeal psoriatic arthropathy
0.000 0.283 0.717
D04.8 Skin of other sites
0.000 0.283 0.716
D04.0 Skin of lip
0.000 0.283 0.716
G37.5 Concentric sclerosis [Balo]
0.715 0.285 0.000
G37.4 Subacute necrotising myelitis
0.715 0.285 0.000
G37.2 Central pontine myelinolysis
0.715 0.285 0.000
G37.1 Central demyelination of corpus callosum
0.715 0.285 0.000
G37.0 Diffuse sclerosis
0.715 0.285 0.000
M06.30 Rheumatoid nodule (Multiple sites)
0.000 0.286 0.714
M06.37 Rheumatoid nodule (Ankle and foot)
0.000 0.286 0.714
D09.1 Other and unspecified urinary organs
0.000 0.286 0.714
C96 Other and unspecified malignant neoplasms of lymphoid, haematopoietic and related tissue
0.000 0.287 0.713
C44.8 Overlapping lesion of skin
0.000 0.288 0.712
D04.6 Skin of upper limb, including shoulder
0.000 0.288 0.712
C85.2 Mediastinal (thymic) large B-cell lymphoma
0.000 0.288 0.712
C85.0 Lymphosarcoma
0.000 0.288 0.712
D06.0 Endocervix
0.000 0.289 0.711
C43.7 Malignant melanoma of lower limb, including hip
0.000 0.289 0.711
M05.91 Seropositive rheumatoid arthritis, unspecified (Shoulder region)
0.000 0.293 0.706
E77 Disorders of glycoprotein metabolism
0.000 0.294 0.706
E76 Disorders of glycosaminoglycan metabolism
0.000 0.294 0.706
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.000 0.294 0.706
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.000 0.294 0.706
E03.1 Congenital hypothyroidism without goitre
0.000 0.297 0.703
C82.6 Cutaneous follicle centre lymphoma
0.000 0.298 0.702
C82.5 Diffuse follicle centre lymphoma
0.000 0.298 0.702
C82.4 Follicular lymphoma grade IIIb
0.000 0.298 0.702
E89.9 Postprocedural endocrine and metabolic disorder, unspecified
0.000 0.298 0.702
E89.5 Postprocedural testicular hypofunction
0.000 0.298 0.702
C69-C72 Malignant neoplasms of eye, brain and other parts of central nervous system
0.000 0.298 0.702
C88 Malignant immunoproliferative diseases
0.000 0.299 0.701
E80 Disorders of porphyrin and bilirubin metabolism
0.000 0.301 0.699
E24 Cushing's syndrome
0.000 0.301 0.699
E89.8 Other postprocedural endocrine and metabolic disorders
0.000 0.301 0.699
D06.7 Other parts of cervix
0.000 0.301 0.699
D06.1 Exocervix
0.000 0.301 0.699
C83.6 Undifferentiated (diffuse)
0.000 0.301 0.699
C83.5 Lymphoblastic (diffuse)
0.000 0.301 0.699
C83.4 Immunoblastic (diffuse)
0.000 0.301 0.699
C83.2 Mixed small and large cell (diffuse)
0.000 0.301 0.699
C91.5 Adult T-cell leukaemia
0.000 0.304 0.696
L42 Pityriasis rosea
0.000 0.305 0.695
C86 Other specified types of T/NK-cell lymphoma
0.000 0.306 0.694
M06.91 Rheumatoid arthritis, unspecified (Shoulder region)
0.000 0.306 0.694
M11 Other crystal arthropathies
0.000 0.309 0.691
C91.0 Acute lymphoblastic leukaemia
0.000 0.309 0.691
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.310 0.690
E32 Diseases of thymus
0.000 0.310 0.690
E31 Polyglandular dysfunction
0.000 0.310 0.690
E30 Disorders of puberty, not elsewhere classified
0.000 0.310 0.690
E89.1 Postprocedural hypoinsulinaemia
0.000 0.315 0.685
M06.08 Seronegative rheumatoid arthritis (Other)
0.000 0.315 0.684
M06.05 Seronegative rheumatoid arthritis (Pelvic region and thigh)
0.000 0.315 0.684
M06.03 Seronegative rheumatoid arthritis (Forearm)
0.000 0.315 0.684
M06.02 Seronegative rheumatoid arthritis (Upper arm)
0.000 0.315 0.684
L40.3 Pustulosis palmaris et plantaris
0.000 0.317 0.682
L40.2 Acrodermatitis continua
0.000 0.317 0.682
L40.4 Guttate psoriasis
0.000 0.319 0.681
E27.3 Drug-induced adrenocortical insufficiency
0.000 0.319 0.681
E03.8 Other specified hypothyroidism
0.000 0.320 0.680
C43.2 Malignant melanoma of ear and external auricular canal
0.000 0.320 0.680
M12 Other specific arthropathies
0.000 0.322 0.678
E88.8 Other specified metabolic disorders
0.000 0.324 0.676
E27.5 Adrenomedullary hyperfunction
0.000 0.325 0.675
E27.0 Other adrenocortical overactivity
0.000 0.325 0.675
E29 Testicular dysfunction
0.000 0.326 0.674
E11.8 With unspecified complications
0.000 0.327 0.673
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.327 0.672
C94 Other leukaemias of specified cell type
0.000 0.328 0.671
D07.2 Vagina
0.000 0.330 0.670
D03.2 Melanoma in situ of ear and external auricular canal
0.000 0.330 0.670
E11.2 With renal complications
0.000 0.331 0.669
L43 Lichen planus
0.000 0.333 0.667
M06.01 Seronegative rheumatoid arthritis (Shoulder region)
0.000 0.333 0.667
E20 Hypoparathyroidism
0.000 0.334 0.666
H30-H36 Disorders of choroid and retina
0.000 0.335 0.665
C12 Malignant neoplasm of pyriform sinus
0.000 0.336 0.664
E16.1 Other hypoglycaemia
0.000 0.337 0.663
C82.3 Follicular lymphoma grade IIIa
0.000 0.339 0.661
D00.1 Oesophagus
0.000 0.342 0.657
D09.9 Carcinoma in situ, unspecified
0.000 0.344 0.656
D09.7 Carcinoma in situ of other specified sites
0.000 0.344 0.656
D09.3 Thyroid and other endocrine glands
0.000 0.344 0.656
D09.2 Eye
0.000 0.344 0.656
C97-C97 Malignant neoplasms of independent (primary) multiple sites
0.000 0.344 0.656
M06.39 Rheumatoid nodule (Site unspecified)
0.000 0.345 0.655
M06.38 Rheumatoid nodule (Other)
0.000 0.345 0.655
M06.36 Rheumatoid nodule (Lower leg)
0.000 0.345 0.655
M06.35 Rheumatoid nodule (Pelvic region and thigh)
0.000 0.345 0.655
M06.33 Rheumatoid nodule (Forearm)
0.000 0.345 0.655
M06.31 Rheumatoid nodule (Shoulder region)
0.000 0.345 0.655
C93 Monocytic leukaemia
0.000 0.345 0.654
H35 Other retinal disorders
0.000 0.347 0.653
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
0.000 0.352 0.648
D04.1 Skin of eyelid, including canthus
0.000 0.353 0.647
E23.2 Diabetes insipidus
0.000 0.356 0.644
E88.9 Metabolic disorder, unspecified
0.000 0.356 0.644
E26 Hyperaldosteronism
0.000 0.356 0.643
E85 Amyloidosis
0.000 0.362 0.638
E15 Nondiabetic hypoglycaemic coma
0.000 0.364 0.636
M05.2 Rheumatoid vasculitis
0.000 0.364 0.636
D03.4 Melanoma in situ of scalp and neck
0.000 0.364 0.636
L57.9 Skin changes due to chronic exposure to nonionising radiation, unspecified
0.000 0.364 0.635
D03.3 Melanoma in situ of other and unspecified parts of face
0.000 0.365 0.635
E73 Lactose intolerance
0.000 0.366 0.634
L44 Other papulosquamous disorders
0.000 0.367 0.633
L45 Papulosquamous disorders in diseases classified elsewhere
0.000 0.367 0.633
E25 Adrenogenital disorders
0.000 0.367 0.633
L57.5 Actinic granuloma
0.000 0.368 0.632
L57.3 Poikiloderma of Civatte
0.000 0.368 0.632
L57.2 Cutis rhomboidalis nuchae
0.000 0.368 0.632
L57.1 Actinic reticuloid
0.000 0.368 0.632
D00.0 Lip, oral cavity and pharynx
0.000 0.369 0.630
D07.4 Penis
0.000 0.371 0.629
C91.4 Hairy-cell leukaemia
0.000 0.372 0.627
H35.8 Other specified retinal disorders
0.000 0.374 0.626
L56 Other acute skin changes due to ultraviolet radiation
0.000 0.376 0.624
E28.2 Polycystic ovarian syndrome
0.000 0.376 0.624
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.000 0.377 0.622
E23.1 Drug-induced hypopituitarism
0.000 0.377 0.622
E27.9 Disorder of adrenal gland, unspecified
0.000 0.378 0.622
M06.40 Inflammatory polyarthropathy (Multiple sites)
0.000 0.379 0.621
M14 Arthropathies in other diseases classified elsewhere
0.000 0.379 0.621
E27.8 Other specified disorders of adrenal gland
0.000 0.380 0.620
L40.0 Psoriasis vulgaris
0.000 0.382 0.618
L41 Parapsoriasis
0.000 0.382 0.618
C02 Malignant neoplasm of other and unspecified parts of tongue
0.000 0.382 0.618
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.000 0.382 0.617
# Top node
0.000 0.383 0.617
C91.8 Mature B-cell leukaemia Burkitt-type
0.000 0.384 0.616
C91.7 Other lymphoid leukaemia
0.000 0.384 0.616
C91.6 Prolymphocytic leukaemia of T-cell type
0.000 0.384 0.616
C91.3 Prolymphocytic leukaemia
0.000 0.384 0.616
C91.2 Subacute lymphocytic leukaemia
0.000 0.384 0.616
M06.06 Seronegative rheumatoid arthritis (Lower leg)
0.000 0.386 0.613
C43.8 Overlapping malignant melanoma of skin
0.000 0.387 0.613
C43.0 Malignant melanoma of lip
0.000 0.387 0.613
H35.6 Retinal haemorrhage
0.000 0.387 0.613
M07.35 Other psoriatic arthropathies (Pelvic region and thigh)
0.000 0.387 0.613
D03.9 Melanoma in situ, unspecified
0.000 0.388 0.612
D03.8 Melanoma in situ of other sites
0.000 0.388 0.612
C95 Leukaemia of unspecified cell type
0.000 0.389 0.611
D03.7 Melanoma in situ of lower limb, including hip
0.000 0.391 0.609
E78.8 Other disorders of lipoprotein metabolism
0.000 0.393 0.607
G36.0 Neuromyelitis optica [Devic]
0.606 0.393 0.000
E27.2 Addisonian crisis
0.000 0.394 0.606
E06.5 Other chronic thyroiditis
0.000 0.394 0.606
L55 Sunburn
0.000 0.397 0.602
C08 Malignant neoplasm of other and unspecified major salivary glands
0.000 0.400 0.600
L59 Other disorders of skin and subcutaneous tissue related to radiation
0.000 0.401 0.599
C43.4 Malignant melanoma of scalp and neck
0.000 0.404 0.596
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.404 0.596
D02.0 Larynx
0.000 0.404 0.596
E78.3 Hyperchylomicronaemia
0.000 0.405 0.595
D03.0 Melanoma in situ of lip
0.000 0.407 0.593
E65-E68 Obesity and other hyperalimentation
0.000 0.407 0.593
M10.0 Idiopathic gout
0.000 0.408 0.592
H35.2 Other proliferative retinopathy
0.000 0.409 0.591
E06.4 Drug-induced thyroiditis
0.000 0.409 0.591
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.409 0.591
E06.0 Acute thyroiditis
0.000 0.409 0.591
C03 Malignant neoplasm of gum
0.000 0.410 0.590
E88.3 Tumour lysis syndrome
0.000 0.412 0.588
E88.1 Lipodystrophy, not elsewhere classified
0.000 0.412 0.588
M06.04 Seronegative rheumatoid arthritis (Hand)
0.000 0.412 0.588
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.000 0.412 0.588
D00.2 Stomach
0.000 0.413 0.586
C88.4 Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue [MALT-lymphoma]
0.000 0.414 0.586
E28.3 Primary ovarian failure
0.000 0.415 0.585
D07.1 Vulva
0.000 0.415 0.585
D01.0 Colon
0.000 0.417 0.583
E72 Other disorders of amino-acid metabolism
0.000 0.420 0.580
E83 Disorders of mineral metabolism
0.048 0.420 0.532
E13.9 Without complications
0.000 0.421 0.579
C71 Malignant neoplasm of brain
0.000 0.422 0.578
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.422 0.578
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.422 0.578
E16.4 Abnormal secretion of gastrin
0.000 0.422 0.578
E16.3 Increased secretion of glucagon
0.000 0.422 0.578
E11.6 With other specified complications
0.000 0.423 0.576
C40-C41 Malignant neoplasms of bone and articular cartilage
0.000 0.424 0.576
M13 Other arthritis
0.000 0.424 0.576
C14 Malignant neoplasm of other and ill-defined sites in the lip, oral cavity and pharynx
0.000 0.425 0.575
C13 Malignant neoplasm of hypopharynx
0.000 0.426 0.573
E40-E46 Malnutrition
0.000 0.429 0.571
C81 Hodgkin's disease
0.000 0.430 0.569
E16.2 Hypoglycaemia, unspecified
0.000 0.431 0.569
L58 Radiodermatitis
0.000 0.432 0.568
C74 Malignant neoplasm of adrenal gland
0.000 0.432 0.568
D37-D48 Neoplasms of uncertain or unknown behaviour
0.000 0.432 0.568
E88.2 Lipomatosis, not elsewhere classified
0.000 0.433 0.567
C11 Malignant neoplasm of nasopharynx
0.000 0.433 0.567
D03.1 Melanoma in situ of eyelid, including canthus
0.000 0.434 0.566
E79.9 Disorder of purine and pyrimidine metabolism, unspecified
0.000 0.434 0.565
E79.8 Other disorders of purine and pyrimidine metabolism
0.000 0.434 0.565
E79.1 Lesch-Nyhan syndrome
0.000 0.434 0.565
L57.4 Cutis laxa senilis
0.000 0.434 0.565
M11.9 Crystal arthropathy, unspecified
0.000 0.437 0.563
H36.8 Other retinal disorders in diseases classified elsewhere
0.000 0.439 0.561
C44.2 Skin of ear and external auricular canal
0.000 0.439 0.561
C07 Malignant neoplasm of parotid gland
0.000 0.439 0.560
E07 Other disorders of thyroid
0.000 0.440 0.560
D01.3 Anus and anal canal
0.000 0.440 0.560
E24.2 Drug-induced Cushing's syndrome
0.000 0.442 0.558
E28.9 Ovarian dysfunction, unspecified
0.000 0.443 0.557
E28.8 Other ovarian dysfunction
0.000 0.443 0.557
E28.1 Androgen excess
0.000 0.443 0.557
E28.0 Oestrogen excess
0.000 0.443 0.557
H30 Chorioretinal inflammation
0.000 0.445 0.555
L43.8 Other lichen planus
0.000 0.446 0.554
G36.9 Acute disseminated demyelination, unspecified
0.552 0.448 0.000
G36.8 Other specified acute disseminated demyelination
0.552 0.448 0.000
G36.1 Acute and subacute haemorrhagic leukoencephalitis [Hurst]
0.552 0.448 0.000
C83.8 Other types of diffuse non-Hodgkin's lymphoma
0.000 0.448 0.552
Chapter VII Diseases of the eye and adnexa
0.000 0.448 0.552
M06.80 Other specified rheumatoid arthritis (Multiple sites)
0.000 0.449 0.551
E70.3 Albinism
0.000 0.451 0.549
E80.1 Porphyria cutanea tarda
0.000 0.451 0.548
D02.4 Respiratory system, unspecified
0.000 0.452 0.548
D02.3 Other parts of respiratory system
0.000 0.452 0.548
D02.2 Bronchus and lung
0.000 0.452 0.548
D02.1 Trachea
0.000 0.452 0.548
D07.6 Other and unspecified male genital organs
0.000 0.454 0.546
D07.3 Other and unspecified female genital organs
0.000 0.454 0.546
C85.7 Other specified types of non-Hodgkin's lymphoma
0.000 0.456 0.544
D43 Neoplasm of uncertain or unknown behaviour of brain and central nervous system
0.000 0.457 0.543
E13.8 With unspecified complications
0.000 0.459 0.541
E13.7 With multiple complications
0.000 0.459 0.541
E13.6 With other specified complications
0.000 0.459 0.541
E13.5 With peripheral circulatory complications
0.000 0.459 0.541
E13.4 With neurological complications
0.000 0.459 0.541
E13.3 With ophthalmic complications
0.000 0.459 0.541
E13.2 With renal complications
0.000 0.459 0.541
E13.1 With ketoacidosis
0.000 0.459 0.541
E13.0 With coma
0.000 0.459 0.541
C84 Peripheral and cutaneous T-cell lymphomas
0.000 0.463 0.537
D03.6 Melanoma in situ of upper limb, including shoulder
0.000 0.463 0.536
C05 Malignant neoplasm of palate
0.000 0.464 0.536
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.464 0.536
E84.9 Cystic fibrosis, unspecified
0.000 0.464 0.536
D01.9 Digestive organ, unspecified
0.000 0.470 0.530
D01.7 Other specified digestive organs
0.000 0.470 0.530
D01.5 Liver, gallbladder and bile ducts
0.000 0.470 0.530
D01.4 Other and unspecified parts of intestine
0.000 0.470 0.530
D01.1 Rectosigmoid junction
0.000 0.470 0.530
M10.4 Other secondary gout
0.000 0.471 0.529
M10.2 Drug-induced gout
0.000 0.471 0.529
M10.1 Lead-induced gout
0.000 0.471 0.529
M10.3 Gout due to impairment of renal function
0.000 0.471 0.529
M06.48 Inflammatory polyarthropathy (Other)
0.000 0.472 0.528
M06.47 Inflammatory polyarthropathy (Ankle and foot)
0.000 0.472 0.528
M06.46 Inflammatory polyarthropathy (Lower leg)
0.000 0.472 0.528
M06.45 Inflammatory polyarthropathy (Pelvic region and thigh)
0.000 0.472 0.528
M06.44 Inflammatory polyarthropathy (Hand)
0.000 0.472 0.528
M06.43 Inflammatory polyarthropathy (Forearm)
0.000 0.472 0.528
M06.42 Inflammatory polyarthropathy (Upper arm)
0.000 0.472 0.528
M06.41 Inflammatory polyarthropathy (Shoulder region)
0.000 0.472 0.528
C75 Malignant neoplasm of other endocrine glands and related structures
0.000 0.473 0.527
C02.9 Tongue, unspecified
0.000 0.473 0.527
D47 Other neoplasms of uncertain or unknown behaviour of lymphoid, haematopoietic and related tissue
0.000 0.474 0.526
E70.9 Disorder of aromatic amino-acid metabolism, unspecified
0.000 0.476 0.524
E70.8 Other disorders of aromatic amino-acid metabolism
0.000 0.476 0.524
E70.2 Disorders of tyrosine metabolism
0.000 0.476 0.524
E70.1 Other hyperphenylalaninaemias
0.000 0.476 0.524
E70.0 Classical phenylketonuria
0.000 0.476 0.524
E21.4 Other specified disorders of parathyroid gland
0.000 0.476 0.524
M06.88 Other specified rheumatoid arthritis (Other)
0.000 0.477 0.523
M06.87 Other specified rheumatoid arthritis (Ankle and foot)
0.000 0.477 0.523
M06.86 Other specified rheumatoid arthritis (Lower leg)
0.000 0.477 0.523
M06.85 Other specified rheumatoid arthritis (Pelvic region and thigh)
0.000 0.477 0.523
M06.84 Other specified rheumatoid arthritis (Hand)
0.000 0.477 0.523
M06.83 Other specified rheumatoid arthritis (Forearm)
0.000 0.477 0.523
M06.82 Other specified rheumatoid arthritis (Upper arm)
0.000 0.477 0.523
M06.81 Other specified rheumatoid arthritis (Shoulder region)
0.000 0.477 0.523
E84.8 Cystic fibrosis with other manifestations
0.000 0.481 0.518
E84.1 Cystic fibrosis with intestinal manifestations
0.000 0.481 0.518
E84.0 Cystic fibrosis with pulmonary manifestations
0.000 0.481 0.518
C04 Malignant neoplasm of floor of mouth
0.000 0.482 0.518
D43.0 Brain, supratentorial
0.000 0.485 0.515
L10-L14 Bullous disorders
0.000 0.485 0.514
E21.2 Other hyperparathyroidism
0.000 0.486 0.514
M06.19 Adult-onset Still's disease (Site unspecified)
0.000 0.486 0.514
M06.18 Adult-onset Still's disease (Other)
0.000 0.486 0.514
M06.17 Adult-onset Still's disease (Ankle and foot)
0.000 0.486 0.514
M06.16 Adult-onset Still's disease (Lower leg)
0.000 0.486 0.514
M06.15 Adult-onset Still's disease (Pelvic region and thigh)
0.000 0.486 0.514
M06.14 Adult-onset Still's disease (Hand)
0.000 0.486 0.514
M06.13 Adult-onset Still's disease (Forearm)
0.000 0.486 0.514
M06.12 Adult-onset Still's disease (Upper arm)
0.000 0.486 0.514
M06.11 Adult-onset Still's disease (Shoulder region)
0.000 0.486 0.514
M06.10 Adult-onset Still's disease (Multiple sites)
0.000 0.486 0.514
M06.29 Rheumatoid bursitis (Site unspecified)
0.000 0.486 0.514
M06.28 Rheumatoid bursitis (Other)
0.000 0.486 0.514
M06.27 Rheumatoid bursitis (Ankle and foot)
0.000 0.486 0.514
M06.26 Rheumatoid bursitis (Lower leg)
0.000 0.486 0.514
M06.25 Rheumatoid bursitis (Pelvic region and thigh)
0.000 0.486 0.514
M06.24 Rheumatoid bursitis (Hand)
0.000 0.486 0.514
M06.23 Rheumatoid bursitis (Forearm)
0.000 0.486 0.514
M06.22 Rheumatoid bursitis (Upper arm)
0.000 0.486 0.514
M06.21 Rheumatoid bursitis (Shoulder region)
0.000 0.486 0.514
M06.20 Rheumatoid bursitis (Multiple sites)
0.000 0.486 0.514
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.000 0.486 0.514
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.000 0.486 0.514

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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