TreeWAS – Variant ID: rs2645424

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	Risk posterior probability	No effect posterior probability	Protective posterior probability
S81.8 Open wound of other parts of lower leg	0.000	0.963	0.037
S81.0 Open wound of knee	0.000	0.964	0.036
S81 Open wound of lower leg	0.000	0.964	0.036
S81.9 Open wound of lower leg, part unspecified	0.000	0.966	0.033
Z03.1 Observation for suspected malignant neoplasm	0.000	0.975	0.025
S81.7 Multiple open wounds of lower leg	0.000	0.976	0.024
L90.0 Lichen sclerosus et atrophicus	0.000	0.977	0.023
K62.6 Ulcer of anus and rectum	0.000	0.977	0.023
T39 Poisoning by nonopioid analgesics, antipyretics and antirheumatics	0.000	0.986	0.014
T45 Poisoning by primarily systemic and haematological agents, not elsewhere classified	0.000	0.986	0.014
T36-T50 Poisoning by drugs, medicaments and biological substances	0.000	0.986	0.014
T39.0 Salicylates	0.000	0.986	0.014
T40.2 Other opioids	0.000	0.986	0.014
T45.2 Vitamins, not elsewhere classified	0.000	0.986	0.014
S42.30 Fracture of shaft of humerus (closed)	0.013	0.987	0.000
T39.3 Other nonsteroidal anti-inflammatory drugs [NSAID]	0.000	0.987	0.013
T40 Poisoning by narcotics and psychodysleptics [hallucinogens]	0.000	0.987	0.013
T45.5 Anticoagulants	0.000	0.987	0.013
T38 Poisoning by hormones and their synthetic substitutes and antagonists, not elsewhere classified	0.000	0.987	0.013
T39.8 Other nonopioid analgesics and antipyretics, not elsewhere classified	0.000	0.988	0.012
T50 Poisoning by diuretics and other and unspecified drugs, medicaments and biological substances	0.000	0.988	0.012
T47 Poisoning by agents primarily affecting gastro-intestinal system	0.000	0.988	0.012
T43 Poisoning by psychotropic drugs, not elsewhere classified	0.000	0.988	0.012
S52.10 Fracture of upper end of radius (closed)	0.000	0.989	0.011
T38.6 Antigonadotrophins. antioestrogens, antiandrogens, not elsewhere classified	0.000	0.989	0.011
T45.0 Antiallergic and antiemetic drugs	0.000	0.989	0.011
T38.1 Thyroid hormones and substitutes	0.000	0.989	0.011
T42 Poisoning by antiepileptic, sedative-hypnotic and anti-Parkinsonism drugs	0.000	0.989	0.011
T46 Poisoning by agents primarily affecting the cardiovascular system	0.000	0.989	0.011
T43.6 Psychostimulants with abuse potential	0.000	0.989	0.011
T36 Poisoning by systemic antibiotics	0.000	0.989	0.010
T39.4 Antirheumatics, not elsewhere classified	0.000	0.989	0.010
T39.2 Pyrazolone derivatives	0.000	0.989	0.010
T45.9 Primarily systemic and haematological agent, unspecified	0.000	0.989	0.010
T45.8 Other primarily systemic and haematological agents	0.000	0.989	0.010
T45.7 Anticoagulant antagonists, vitamin K and other coagulants	0.000	0.989	0.010
T45.6 Fibrinolysis-affecting drugs	0.000	0.989	0.010
T45.4 Iron and its compounds	0.000	0.989	0.010
T45.3 Enzymes, not elsewhere classified	0.000	0.989	0.010
T48 Poisoning by agents primarily acting on smooth and skeletal muscles and the respiratory system	0.000	0.989	0.010
T40.5 Cocaine	0.000	0.990	0.010
T47.1 Other antacids and anti-gastric-secretion drugs	0.000	0.990	0.010
T50.6 Antidotes and chelating agents, not elsewhere classified	0.000	0.990	0.010
T43.2 Other and unspecified antidepressants	0.000	0.990	0.010
T50.8 Diagnostic agents	0.000	0.990	0.010
T39.9 Nonopioid analgesic, antipyretic and antirheumatic, unspecified	0.000	0.990	0.010
T40.1 Heroin	0.000	0.990	0.010
T41 Poisoning by anaesthetics and therapeutic gases	0.000	0.990	0.010
T38.0 Glucocorticoids and synthetic analogues	0.000	0.990	0.010
T45.1 Antineoplastic and immunosuppressive drugs	0.000	0.990	0.009
T40.9 Other and unspecified psychodysleptics [hallucinogens]	0.000	0.991	0.009
T40.8 Lysergide [LSD]	0.000	0.991	0.009
T40.7 Cannabis (derivatives)	0.000	0.991	0.009
T40.0 Opium	0.000	0.991	0.009
T43.3 Phenothiazine antipsychotics and neuroleptics	0.000	0.991	0.009
T38.9 Other and unspecified hormone antagonists	0.000	0.991	0.009
T38.7 Androgens and anabolic congeners	0.000	0.991	0.009
T38.5 Other oestrogens and progestogens	0.000	0.991	0.009
T38.4 Oral contraceptives	0.000	0.991	0.009
T38.2 Antithyroid drugs	0.000	0.991	0.009
T49 Poisoning by topical agents primarily affecting skin and mucous membrane and by ophthalmological, otorhinolarygological and dental drugs	0.000	0.991	0.009
T38.3 Insulin and oral hypoglycaemic [antidiabetic] drugs	0.000	0.991	0.009
T46.1 Calcium-channel blockers	0.000	0.991	0.009
T47.0 Histamine H(2)-receptor antagonists	0.000	0.991	0.009
C18.3 Hepatic flexure	0.009	0.991	0.000
T43.4 Butyrophenone and thioxanthene neuroleptics	0.000	0.991	0.009
T50.9 Other and unspecified drugs, medicaments and biological substances	0.000	0.991	0.009
T50.2 Carbonic-anhydrase inhibitors, benzothiadiazides and other diuretics	0.000	0.991	0.009
T50.7 Analeptics and opioid receptor antagonists	0.000	0.991	0.009
T50.5 Appetite depressants	0.000	0.991	0.009
T50.3 Electrolytic, caloric and water-balance agents	0.000	0.991	0.009
T50.0 Mineralocorticoids and their antagonists	0.000	0.991	0.009
T37 Poisoning by other systemic anti-infectives and antiparasitics	0.000	0.991	0.009
T47.2 Stimulant laxatives	0.000	0.991	0.009
T43.9 Psychotropic drug, unspecified	0.000	0.991	0.009
T42.1 Iminostilbenes	0.000	0.991	0.009
T50.4 Drugs affecting uric acid metabolism	0.000	0.991	0.009
T43.8 Other psychotropic drugs, not elsewhere classified	0.000	0.991	0.009
T47.9 Agent primarily affecting the gastro-intestinal system, unspecified	0.000	0.991	0.009
T47.8 Other agents primarily affecting the gastro-intestinal system	0.000	0.991	0.009
T47.7 Emetics	0.000	0.991	0.009
T47.5 Digestants	0.000	0.991	0.009
T47.3 Saline and osmotic laxatives	0.000	0.991	0.009
T48.6 Antiasthmatics, not elsewhere classified	0.000	0.991	0.008
T43.1 Monoamine-oxidase-inhibitor antidepressants	0.000	0.991	0.008
T46.5 Other antihypertensive drugs, not elsewhere classified	0.000	0.991	0.008
T42.8 Anti-Parkinsonism drugs and other central muscle-tone depressants	0.000	0.992	0.008
T40.3 Methadone	0.000	0.992	0.008
T42.4 Benzodiazepines	0.000	0.992	0.008
T36.3 Macrolides	0.000	0.992	0.008
T50.1 Loop [high-ceiling] diuretics	0.000	0.992	0.008
T47.4 Other laxatives	0.000	0.992	0.008
T38.8 Other and unspecified hormones and their synthetic substitutes	0.000	0.992	0.008
T42.3 Barbiturates	0.000	0.992	0.008
T46.2 Other antidysrhythmic drugs, not elsewhere classified	0.000	0.992	0.008
T42.5 Mixed antiepileptics, not elsewhere classified	0.000	0.992	0.008
T42.2 Succinimides and oxazolidinediones	0.000	0.992	0.008
T46.8 Antivaricose drugs, including sclerosing agents	0.000	0.992	0.008
T46.7 Peripheral vasodilators	0.000	0.992	0.008
T46.0 Cardiac-stimulant glycosides and drugs of similar action	0.000	0.992	0.008
T36.9 Systemic antibiotic, unspecified	0.000	0.992	0.008
T36.8 Other systemic antibiotics	0.000	0.992	0.008
T36.7 Antifungal antibiotics, systemically used	0.000	0.992	0.008
T36.6 Rifamycins	0.000	0.992	0.008
T36.5 Aminoglycosides	0.000	0.992	0.008
T36.2 Chloramphenicol group	0.000	0.992	0.008
T36.1 Cefalosporins and other Beta-lactam antibiotics	0.000	0.992	0.008
T48.7 Other and unspecified agents primarily acting on the respiratory system	0.000	0.992	0.008
T48.4 Expectorants	0.000	0.992	0.008
T48.3 Antitussives	0.000	0.992	0.008
T48.2 Other and unspecified agents primarily acting on muscles	0.000	0.992	0.008
T48.1 Skeletal muscle relaxants [neuromuscular blocking agents]	0.000	0.992	0.008
T48.0 Oxytocic drugs	0.000	0.992	0.008
T47.6 Antidiarrhoeal drugs	0.000	0.992	0.007
T36.4 Tetracyclines	0.000	0.992	0.007
J34.8 Other specified disorders of nose and nasal sinuses	0.000	0.992	0.008
T36.0 Penicillins	0.000	0.992	0.007
T46.9 Other and unspecified agents primarily affecting the cardiovascular system	0.000	0.992	0.007
Y84.8 Other medical procedures	0.008	0.992	0.000
T46.3 Coronary vasodilators, not elsewhere classified	0.000	0.993	0.007
T41.5 Therapeutic gases	0.000	0.993	0.007
T41.4 Anaesthetic, unspecified	0.000	0.993	0.007
T41.3 Local anaesthetics	0.000	0.993	0.007
T41.1 Intravenous anaesthetics	0.000	0.993	0.007
T41.0 Inhaled anaesthetics	0.000	0.993	0.007
T46.4 Angiotensin-converting-enzyme inhibitors	0.000	0.993	0.007
C77.8 Lymph nodes of multiple regions	0.000	0.993	0.007
T42.0 Hydantoin derivatives	0.000	0.993	0.007
T42.6 Other antiepileptic and sedative-hypnotic drugs	0.000	0.993	0.007
G93.8 Other specified disorders of brain	0.000	0.993	0.007
T49.9 Topical agent, unspecified	0.000	0.993	0.007
T49.8 Other topical agents	0.000	0.993	0.007
T49.7 Dental drugs, topically applied	0.000	0.993	0.007
T49.6 Otorhinolaryngological drugs and preparations	0.000	0.993	0.007
T49.5 Ophthalmological drugs and preparations	0.000	0.993	0.007
T49.4 Keratolytics, keratoplastics and other hair treatment drugs and preparations	0.000	0.993	0.007
T49.3 Emollients, demulcents and protectants	0.000	0.993	0.007
T49.2 Local astringents and local detergents	0.000	0.993	0.007
T49.1 Antipruritics	0.000	0.993	0.007
T44 Poisoning by drugs primarily affecting the autonomic nervous system	0.000	0.993	0.007
T42.7 Antiepileptic and sedative-hypnotic drugs, unspecified	0.000	0.993	0.007
T40.6 Other and unspecified narcotics	0.000	0.993	0.007
T41.2 Other and unspecified general anaesthetics	0.000	0.993	0.006
T48.5 Anti-common-cold drugs	0.000	0.993	0.006
T37.9 Systemic anti-infective and antiparasitic, unspecified	0.000	0.993	0.006
T37.5 Antiviral drugs	0.000	0.993	0.006
T37.4 Anthelminthics	0.000	0.993	0.006
T37.3 Other antiprotozoal drugs	0.000	0.993	0.006
T37.2 Antimalarials and drugs acting on other blood protozoa	0.000	0.993	0.006
T37.1 Antimycobacterial drugs	0.000	0.993	0.006
T37.0 Sulphonamides	0.000	0.993	0.006
I21.0 Acute transmural myocardial infarction of anterior wall	0.000	0.993	0.007
T46.6 Antihyperlipidaemic and antiarteriosclerotic drugs	0.000	0.994	0.006
T43.5 Other and unspecified antipsychotics and neuroleptics	0.000	0.994	0.006
L72.1 Trichilemmal cyst	0.006	0.994	0.000
F20.9 Schizophrenia, unspecified	0.000	0.994	0.006
T49.0 Local antifungal, anti-infective and anti-inflammatory drugs, not elsewhere classified	0.000	0.994	0.005
S42.3 Fracture of shaft of humerus	0.006	0.994	0.000
T44.9 Other and unspecified drugs primarily affecting the nervous system	0.000	0.994	0.005
O72.2 Delayed and secondary postpartum haemorrhage	0.000	0.995	0.005
T44.8 Centrally acting and afrenergic-neuron-blocking agents, not elsewhere classified	0.000	0.995	0.005
T44.5 Predominantly Beta-adrenoreceptor agonists, not elsewhere classified	0.000	0.995	0.005
T44.4 Predominantly Alpha-adrenoreceptor agonists, not elsewhere classified	0.000	0.995	0.005
T44.2 Ganglionic blocking drugs, not elsewhere classified	0.000	0.995	0.005
T44.1 Other parasympathomimetics [cholinergics]	0.000	0.995	0.005
T44.0 Anticholinesterase agents	0.000	0.995	0.005
T37.8 Other specified systemic anti-infectives and antiparasitics	0.000	0.995	0.005
F20 Schizophrenia	0.000	0.995	0.005
F22.0 Delusional disorder	0.000	0.995	0.005
T39.1 4-Aminophenol derivatives	0.000	0.995	0.005
T43.0 Tricyclic and tetracyclic antidepressants	0.000	0.995	0.005
F22 Persistent delusional disorders	0.000	0.995	0.005
T44.7 Beta-Adrenoreceeptor antagonists, not elsewhere classified	0.000	0.995	0.004
S52.80 Fracture of other parts of forearm (closed)	0.005	0.995	0.000
F20.5 Residual schizophrenia	0.000	0.995	0.005
J35.8 Other chronic diseases of tonsils and adenoids	0.000	0.996	0.004
F20-F29 Schizophrenia, schizotypal and delusional disorders	0.000	0.996	0.004
S52.1 Fracture of upper end of radius	0.000	0.996	0.004
T40.4 Other synthetic narcotics	0.001	0.996	0.004
T44.6 Alpha-Adrenoreceeptor antagonists, not elsewhere classified	0.000	0.996	0.004
L90 Atrophic disorders of skin	0.000	0.996	0.004
F29 Unspecified nonorganic psychosis	0.000	0.996	0.004
F22.9 Persistent delusional disorder, unspecified	0.000	0.996	0.004
H80.9 Otosclerosis, unspecified	0.000	0.996	0.004
H66.3 Other chronic suppurative otitis media	0.000	0.996	0.004
S42.31 Fracture of shaft of humerus (open)	0.004	0.996	0.000
S86.8 Injury of other muscles and tendons at lower leg level	0.004	0.996	0.000
F20.8 Other schizophrenia	0.000	0.996	0.004
F20.6 Simple schizophrenia	0.000	0.996	0.004
F20.4 Postschizophrenic depression	0.000	0.996	0.004
F20.3 Undifferentiated schizophrenia	0.000	0.996	0.004
F20.1 Hebephrenic schizophrenia	0.000	0.996	0.004
T44.3 Other parasympatholytics [anticholinergics and antimuscarines] and spasmolytics, not elsewhere classified	0.000	0.996	0.003
F25 Schizoaffective disorders	0.000	0.996	0.004
F22.8 Other persistent delusional disorders	0.000	0.996	0.004
S82.40 Fracture of fibula alone (closed)	0.000	0.996	0.004
M65.96 Synovitis and tenosynovitis, unspecified (Lower leg)	0.004	0.996	0.000
F28 Other nonorganic psychotic disorders	0.000	0.997	0.003
F24 Induced delusional disorder	0.000	0.997	0.003
F21 Schizotypal disorder	0.000	0.997	0.003
C02.9 Tongue, unspecified	0.003	0.997	0.000
F20.2 Catatonic schizophrenia	0.000	0.997	0.003
L90.9 Atrophic disorder of skin, unspecified	0.000	0.997	0.003
L90.6 Striae atrophicae	0.000	0.997	0.003
L90.4 Acrodermatitis chronica atrophicans	0.000	0.997	0.003
L90.3 Atrophoderma of Pasini and Pierini	0.000	0.997	0.003
L90.2 Anetoderma of Jadassohn-Pellizzari	0.000	0.997	0.003
L90.1 Anetoderma of Schweninger-Buzzi	0.000	0.997	0.003
F20.0 Paranoid schizophrenia	0.000	0.997	0.003
F25.9 Schizoaffective disorder, unspecified	0.000	0.997	0.003
Y40.9 Systemic antibiotic, unspecified	0.000	0.997	0.003
L90.8 Other atrophic disorders of skin	0.000	0.997	0.003
S52.11 Fracture of upper end of radius (open)	0.000	0.997	0.003
J04.0 Acute laryngitis	0.000	0.997	0.003
J20.9 Acute bronchitis, unspecified	0.003	0.997	0.000
F25.0 Schizoaffective disorder, manic type	0.000	0.997	0.003
F25.8 Other schizoaffective disorders	0.000	0.997	0.003
H66.0 Acute suppurative otitis media	0.000	0.997	0.003
F25.2 Schizoaffective disorder, mixed type	0.000	0.997	0.003
F25.1 Schizoaffective disorder, depressive type	0.000	0.997	0.003
H66 Suppurative and unspecified otitis media	0.000	0.997	0.003
F23 Acute and transient psychotic disorders	0.000	0.997	0.003
S02.60 Fracture of mandible (closed)	0.000	0.997	0.003
H66.9 Otitis media, unspecified	0.000	0.997	0.003
S20.8 Superficial injuries of other and unspecified parts of thorax	0.000	0.997	0.003
J35 Chronic diseases of tonsils and adenoids	0.000	0.997	0.003
F10.1 Harmful use	0.000	0.997	0.003
Z95.0 Presence of cardiac pacemaker	0.000	0.997	0.003
J35.0 Chronic tonsillitis	0.000	0.997	0.003
T68 Hypothermia	0.003	0.997	0.000
M21.37 Wrist or foot drop (acquired) (Ankle and foot)	0.003	0.997	0.000
C16.5 Lesser curvature of stomach, unspecified	0.003	0.997	0.000
M77.47 Metatarsalgia-Ankle/Foot	0.000	0.997	0.003
L72.9 Follicular cyst of skin and subcutaneous tissue, unspecified	0.003	0.997	0.000
O62.3 Precipitate labour	0.000	0.998	0.002
S52.8 Fracture of other parts of forearm	0.002	0.998	0.000
H66.2 Chronic atticoantral suppurative otitis media	0.000	0.998	0.002
O72 Postpartum haemorrhage	0.000	0.998	0.002
F23.3 Other acute predominantly delusional psychotic disorders	0.000	0.998	0.002
J35.2 Hypertrophy of adenoids	0.000	0.998	0.002
L72 Follicular cysts of skin and subcutaneous tissue	0.002	0.998	0.000
M96.0 Pseudarthrosis after fusion or arthrodesis	0.000	0.998	0.002
S86 Injury of muscle and tendon at lower leg level	0.002	0.998	0.001
F23.8 Other acute and transient psychotic disorders	0.000	0.998	0.002
F23.2 Acute schizophrenia-like psychotic disorder	0.000	0.998	0.002
F23.1 Acute polymorphic psychotic disorder with symptoms of schizophrenia	0.000	0.998	0.002
S89 Other and unspecified injuries of lower leg	0.000	0.998	0.002
S89.9 Unspecified injury of lower leg	0.000	0.998	0.002
S50.9 Superficial injury of forearm, unspecified	0.000	0.998	0.002
J35.3 Hypertrophy of tonsils with hypertrophy of adenoids	0.000	0.998	0.002
H66.1 Chronic tubotympanic suppurative otitis media	0.000	0.998	0.002
S82.4 Fracture of fibula alone	0.000	0.998	0.002
S80-S89 Injuries to the knee and lower leg	0.000	0.998	0.002
J35.1 Hypertrophy of tonsils	0.000	0.998	0.002
S27.30 Other injuries of lung (without open wound into thoracic cavity)	0.000	0.998	0.002
Y77.3 Surgical instruments, materials and devices (including sutures)	0.000	0.998	0.002
S52.81 Fracture of other parts of forearm (open)	0.002	0.998	0.000
C02 Malignant neoplasm of other and unspecified parts of tongue	0.002	0.998	0.000
S89.8 Other specified injuries of lower leg	0.000	0.998	0.002
B16.9 Acute hepatitis B without delta-agent and without hepatic coma	0.002	0.998	0.000
S86.3 Injury of muscle(s) and tendon(s) of peroneal muscle group at lower leg level	0.002	0.998	0.000
W29.9 Unspecified place	0.002	0.998	0.000
F23.0 Acute polymorphic psychotic disorder without symptoms of schizophrenia	0.000	0.998	0.002
L72.2 Steatocystoma multiplex	0.002	0.998	0.000
X59.3 Sports and athletics area	0.002	0.998	0.000
C02.3 Anterior two-thirds of tongue, part unspecified	0.002	0.998	0.000
O72.3 Postpartum coagulation defects	0.000	0.998	0.002
G82.5 Tetraplegia, unspecified	0.000	0.998	0.002
L57.8 Other skin changes due to chronic exposure to nonionising radiation	0.002	0.998	0.000
Z75.3 Unavailability and inaccessibility of health-care facilities	0.000	0.998	0.002
O72.0 Third-stage haemorrhage	0.000	0.998	0.002
S86.0 Injury of Achilles tendon	0.001	0.998	0.001
S86.7 Injury of multiple muscles and tendons at lower leg level	0.001	0.998	0.001
M20.3 Other deformity of hallux (acquired)	0.000	0.998	0.002
N49.2 Inflammatory disorders of scrotum	0.002	0.998	0.000
J35.9 Chronic disease of tonsils and adenoids, unspecified	0.000	0.998	0.002
L72.8 Other follicular cysts of skin and subcutaneous tissue	0.002	0.998	0.000
S89.7 Multiple injuries of lower leg	0.000	0.998	0.002
S89.1 Other specified injuries of lower leg	0.000	0.998	0.002
S89.0 Multiple injuries of lower leg	0.000	0.998	0.002
Z50.5 Speech therapy	0.002	0.998	0.000
M21.07 Valgus deformity, not elsewhere classified (Ankle and foot)	0.002	0.998	0.000
S82.50 Fracture of medial malleolus (closed)	0.002	0.998	0.000
C02.1 Border of tongue	0.002	0.998	0.000
D16.2 Long bones of lower limb	0.000	0.998	0.002
K86.1 Other chronic pancreatitis	0.000	0.998	0.002
O72.1 Other immediate postpartum haemorrhage	0.000	0.998	0.002
S86.1 Injury of other muscle(s) and tendon(s) of posterior muscle group at lower leg level	0.001	0.998	0.001
Y76.2 Prosthetic and other implants, materials and accessory devices	0.000	0.998	0.002
S82.41 Fracture of fibula alone (open)	0.000	0.998	0.002
A41.5 Septicaemia due to other Gram-negative organisms	0.002	0.998	0.000
S86.2 Injury of muscle(s) and tendon(s) of anterior muscle group at lower leg level	0.001	0.998	0.001
J61 Pneumoconiosis due to asbestos and other mineral fibres	0.000	0.998	0.002
S88 Traumatic amputation of lower leg	0.000	0.998	0.002
S85 Injury of blood vessels at lower leg level	0.000	0.998	0.002
S84 Injury of nerves at lower leg level	0.000	0.998	0.002
F23.9 Acute and transient psychotic disorder, unspecified	0.000	0.998	0.002
C02.8 Overlapping lesion of tongue	0.002	0.998	0.000
C02.0 Dorsal surface of tongue	0.002	0.998	0.000
C51.9 Vulva, unspecified	0.000	0.998	0.002
G31.2 Degeneration of nervous system due to alcohol	0.000	0.998	0.002
H80 Otosclerosis	0.000	0.998	0.002
S87 Crushing injury of lower leg	0.000	0.998	0.002
C02.4 Lingual tonsil	0.002	0.998	0.000
H66.4 Suppurative otitis media, unspecified	0.000	0.998	0.002
I69.4 Sequelae of stroke, not specified as haemorrhage or infarction	0.000	0.998	0.002
S86.9 Injury of unspecified muscle and tendon at lower leg level	0.001	0.998	0.001
M77.97 Enthesopathy, unspecified (Ankle and foot)	0.000	0.998	0.002
K41.9 Unilateral or unspecified femoral hernia, without obstruction or gangrene	0.000	0.998	0.002
C16.9 Stomach, unspecified	0.002	0.998	0.000
N92.5 Other specified irregular menstruation	0.000	0.998	0.002
T85.3 Mechanical complication of other ocular prosthetic devices, imnplants and grafts	0.000	0.998	0.002
S86.00 Unspecified injury of Achilles tendon	0.001	0.998	0.001
C02.2 Ventral surface of tongue	0.002	0.998	0.000
I69.3 Sequelae of cerebral infarction	0.000	0.998	0.002
C16.2 Body of stomach	0.002	0.998	0.000
H21.8 Other specified disorders of iris and ciliary body	0.000	0.998	0.002
Z75.8 Other problems related to medical facilities and other health care	0.000	0.998	0.002
J20 Acute bronchitis	0.002	0.998	0.000
S52.00 Fracture of upper end of ulna (closed)	0.000	0.998	0.002
I47.2 Ventricular tachycardia	0.000	0.998	0.002
S20.2 Contusion of thorax	0.001	0.998	0.000
V48.4 Person injured while boarding or alighting	0.000	0.998	0.002
M94.96 Disorder of cartilage, unspecified (Lower leg)	0.000	0.998	0.002
L28.0 Lichen simplex chronicus	0.002	0.998	0.000
M77.4 Metatarsalgia	0.000	0.998	0.002
S61.7 Multiple open wounds of wrist and hand	0.002	0.998	0.000
S84.9 Injury of unspecified nerve at lower leg level	0.000	0.998	0.001
S84.8 Injury of other nerves at lower leg level	0.000	0.998	0.001
S84.7 Injury of multiple nerves at lower leg level	0.000	0.998	0.001
S84.2 Injury of cutaneous sensory nerve at lower leg level	0.000	0.998	0.001
S84.1 Injury of peroneal nerve at lower leg level	0.000	0.998	0.001
S84.0 Injury of tibial nerve at lower leg level	0.000	0.998	0.001
S85.9 Injury of unspecified blood vessel at lower leg level	0.000	0.998	0.001
S85.8 Injury of other blood vessels at lower leg level	0.000	0.998	0.001
S85.7 Injury of multiple blood vessels at lower leg level	0.000	0.998	0.001
S85.5 Injury of popliteal vein	0.000	0.998	0.001
S85.4 Injury of lesser saphenous vein at lower leg level	0.000	0.998	0.001
S85.3 Injury of greater saphenous vein at lower leg level	0.000	0.998	0.001
S85.2 Injury of peroneal artery	0.000	0.998	0.001
S85.1 Injury of (anterior)(posterior) tibial artery	0.000	0.998	0.001
S85.0 Injury of popliteal artery	0.000	0.998	0.001
S88.9 Traumatic amputation of lower leg, level unspecified	0.000	0.998	0.001
S88.1 Traumatic amputation at level between knee and ankle	0.000	0.998	0.001
S88.0 Traumatic amputation at knee level	0.000	0.998	0.001
Y77.2 Prosthetic and other implants, materials and accessory devices	0.000	0.998	0.001
Y85.9 Sequelae of other and unspecified transport accidents	0.000	0.998	0.002
M89.86 Other specified disorders of bone (Lower leg)	0.002	0.998	0.000
Y77 Ophthalmic devices associated with adverse incidents	0.000	0.998	0.002
H80.8 Other otosclerosis	0.000	0.998	0.001
H80.2 Cochlear otosclerosis	0.000	0.998	0.001
H80.1 Otosclerosis involving oval window, obliterative	0.000	0.998	0.001
K86.2 Cyst of pancreas	0.000	0.998	0.002
S87.0 Crushing injury of knee	0.000	0.998	0.001
Z91.0 Personal history of allergy, other than to drugs and biological substances	0.000	0.998	0.002
X59 Exposure to unspecified factor	0.002	0.998	0.000
M89.85 Other specified disorders of bone (Pelvic region and thigh)	0.002	0.998	0.000
S20.4 Other superficial injuries of back wall of thorax	0.000	0.998	0.001
Y04.8 Other specified place	0.000	0.998	0.002
Y52.3 Coronary vasodilators, not elsewhere classified	0.000	0.998	0.002
I69.8 Sequelae of other and unspecified cerebrovascular diseases	0.000	0.998	0.002
J20.8 Acute bronchitis due to other specified organisms	0.001	0.998	0.000
Z75.2 Other waiting period for investigation and treatment	0.000	0.998	0.002
I69 Sequelae of cerebrovascular disease	0.000	0.998	0.002
S87.8 Crushing injury of other and unspecified parts of lower leg	0.000	0.998	0.001
I69.1 Sequelae of intracerebral haemorrhage	0.000	0.998	0.001
N87.9 Dysplasia of cervix uteri, unspecified	0.000	0.998	0.002
Q18.1 Preauricular sinus and cyst	0.000	0.998	0.001
X59.2 School, other institution and public administrative area	0.001	0.998	0.000
H10.9 Conjunctivitis, unspecified	0.000	0.998	0.001
G36.0 Neuromyelitis optica [Devic]	0.000	0.999	0.001
H80.0 Otosclerosis involving oval window, nonobliterative	0.000	0.999	0.001
J20.7 Acute bronchitis due to echovirus	0.001	0.999	0.000
J20.6 Acute bronchitis due to rhinovirus	0.001	0.999	0.000
J20.5 Acute bronchitis due to respiratory syncytial virus	0.001	0.999	0.000
J20.4 Acute bronchitis due to parainfluenza virus	0.001	0.999	0.000
J20.3 Acute bronchitis due to coxsackie virus	0.001	0.999	0.000
J20.2 Acute bronchitis due to streptococcus	0.001	0.999	0.000
J20.1 Acute bronchitis due to Haemophilus influenzae	0.001	0.999	0.000
J20.0 Acute bronchitis due to Mycoplasma pneumoniae	0.001	0.999	0.000
T71 Asphyxiation	0.001	0.999	0.000
M89.81 Other specified disorders of bone (Shoulder region)	0.001	0.999	0.000
S32.10 Fracture of sacrum (closed)	0.001	0.999	0.000
C16.1 Fundus of stomach	0.001	0.999	0.000
F33.0 Recurrent depressive disorder, current episode mild	0.000	0.999	0.001
I45.9 Conduction disorder, unspecified	0.000	0.999	0.001
S63.6 Sprain and strain of finger(s)	0.001	0.999	0.000
C16 Malignant neoplasm of stomach	0.001	0.999	0.000
M77.49 Metatarsalgia-Site unspec	0.000	0.999	0.001
M77.48 Metatarsalgia-Other	0.000	0.999	0.001
M77.46 Metatarsalgia-Lower Leg	0.000	0.999	0.001
M77.45 Metatarsalgia-Pelvic/Thigh	0.000	0.999	0.001
M77.44 Metatarsalgia-Hand	0.000	0.999	0.001
M77.43 Metatarsalgia-Forearm	0.000	0.999	0.001
M77.42 Metatarsalgia-Upper arm	0.000	0.999	0.001
M77.41 Metatarsalgia-Shldr region	0.000	0.999	0.001
M77.40 Metatarsalgia-Mult sites	0.000	0.999	0.001
X59.6 Industrial and construction area	0.001	0.999	0.000
Z75.4 Unavailability and inaccessibility of other helping agencies	0.000	0.999	0.001
M23.51 Chronic instability of knee (Anterior cruciate ligament or Anterior horn of medial meniscus)	0.000	0.999	0.001
D11.0 Parotid gland	0.000	0.999	0.001
F05.9 Delirium, unspecified	0.000	0.999	0.001
I69.2 Sequelae of other nontraumatic intracranial haemorrhage	0.000	0.999	0.001
S02.6 Fracture of mandible	0.000	0.999	0.001
X59.4 Street and highway	0.001	0.999	0.000
Y77.8 Miscellaneous devices, not elsewhere classified	0.000	0.999	0.001
Y77.1 Therapeutic (nonsurgical) and rehabilitative devices	0.000	0.999	0.001
Y77.0 Diagnostic and monitoring devices	0.000	0.999	0.001
B16 Acute hepatitis B	0.001	0.999	0.000
H47.2 Optic atrophy	0.000	0.999	0.001
T65.9 Toxic effect of unspecified substance	0.000	0.999	0.001
X59.9 Unspecified place	0.001	0.999	0.000
X59.8 Other specified place	0.001	0.999	0.000
X59.0 Home	0.001	0.999	0.000
X59.7 Farm	0.001	0.999	0.000
X59.5 Trade and service area	0.001	0.999	0.000
X59.1 Residential institution	0.001	0.999	0.000
S20 Superficial injury of thorax	0.000	0.999	0.001
D47.2 Monoclonal gammopathy	0.001	0.999	0.000
L92.9 Granulomatous disorder of skin and subcutaneous tissue, unspecified	0.000	0.999	0.001
B17.2 Acute hepatitis E	0.001	0.999	0.000
S42.70 Multiple fractures of clavicle, scapula and humerus (closed)	0.001	0.999	0.000
S20.0 Contusion of breast	0.000	0.999	0.001
M81.40 Drug-induced osteoporosis (Multiple sites)	0.000	0.999	0.001
K86.8 Other specified diseases of pancreas	0.000	0.999	0.001
Y88.3 Sequelae of surgical and medical procedures as the cause of abnormal reaction of the patient or of later complication, without mention of misadventure at the time of the procedure	0.000	0.999	0.001
Z11.2 Special screening examination for other bacterial diseases	0.001	0.999	0.000
C16.3 Pyloric antrum	0.001	0.999	0.000
Y48.4 Anaesthetic, unspecified	0.000	0.999	0.001
Z75 Problems related to medical facilities and other health care	0.000	0.999	0.001
S63.4 Traumatic rupture of ligament of finger at metacarpophalangeal and interphalangeal joint(s)	0.001	0.999	0.000
W29.5 Trade and service area	0.001	0.999	0.000
Y76 Obstetric and gynaecological devices associated with adverse incidents	0.000	0.999	0.001
S02.61 Fracture of mandible (open)	0.000	0.999	0.001
X59.09 Exposure to unspecified factor causing fracture; Unspecified place;	0.001	0.999	0.000
X59.88 Exposure to unspecified factor; Other specified places ;While engaged in other specified activities	0.001	0.999	0.000
X59.99 Exposure to unspecified factor causing other and unspecified injury, Unspecified place	0.001	0.999	0.000
B16.2 Acute hepatitis B without delta-agent with hepatic coma	0.001	0.999	0.000
B16.1 Acute hepatitis B with delta-agent (coinfection) without hepatic coma	0.001	0.999	0.000
B16.0 Acute hepatitis B with delta-agent (coinfection) with hepatic coma	0.001	0.999	0.000
C57.0 Fallopian tube	0.000	0.999	0.001
H10.4 Chronic conjunctivitis	0.000	0.999	0.001
O99.0 Anaemia complicating pregnancy, childbirth and the puerperium	0.000	0.999	0.001
V48.0 Driver injured in nontraffic accident	0.000	0.999	0.001
Y52.1 Calcium-channel blockers	0.000	0.999	0.001
S20.7 Multiple superficial injuries of thorax	0.000	0.999	0.001
S20.3 Other superficial injuries of front wall of thorax	0.000	0.999	0.001
T63.4 Venom of other arthropods	0.000	0.999	0.001
W20.8 Other specified place	0.001	0.999	0.000
Y52.6 Antihyperlipidaemic and antiarteriosclerotic drugs	0.000	0.999	0.001
M77.95 Enthesopathy, unspecified (Pelvic region and thigh)	0.000	0.999	0.001
E22.1 Hyperprolactinaemia	0.001	0.999	0.000
M89.8 Other specified disorders of bone	0.001	0.999	0.000
S20.1 Other and unspecified superficial injuries of breast	0.000	0.999	0.001
S96.8 Injury of other muscles and tendons at ankle and foot level	0.001	0.999	0.000
V48.6 Passenger injured in traffic accident	0.000	0.999	0.001
W29 Contact with other powered hand tools and household machinery	0.001	0.999	0.000
C16.8 Overlapping lesion of stomach	0.001	0.999	0.000
M21.3 Wrist or foot drop (acquired)	0.001	0.999	0.000
Y52 Agents primarily affecting the cardiovascular system	0.000	0.999	0.001
T66-T78 Other and unspecified effects of external causes	0.001	0.999	0.000
M40.29 Other and unspecified kyphosis (Site unspecified)	0.000	0.999	0.001
D16.3 Short bones of lower limb	0.000	0.999	0.001
T09.3 Injury of spinal cord, level unspecified	0.000	0.999	0.001
X58.3 Sports and athletics area	0.001	0.999	0.000
Y52.7 Peripheral vasodilators	0.000	0.999	0.001
Z50.2 Alcohol rehabilitation	0.000	0.999	0.001
K86 Other diseases of pancreas	0.000	0.999	0.001
S82.5 Fracture of medial malleolus	0.001	0.999	0.001
Y52.0 Cardiac-stimulant glycosides and drugs of similar action	0.000	0.999	0.001
Y76.8 Miscellaneous devices, not elsewhere classified	0.000	0.999	0.001
Y76.3 Surgical instruments, materials and devices (including sutures)	0.000	0.999	0.001
Y76.1 Therapeutic (nonsurgical) and rehabilitative devices	0.000	0.999	0.001
Y76.0 Diagnostic and monitoring devices	0.000	0.999	0.001
Z75.9 Unspecified problem related to medical facilities and other health care	0.000	0.999	0.001
T66 Unspecified effects of radiation	0.001	0.999	0.000
I69.0 Sequelae of subarachnoid haemorrhage	0.000	0.999	0.001
T78.0 Anaphylactic shock due to adverse food reaction	0.001	0.999	0.000
M89.82 Other specified disorders of bone (Upper arm)	0.001	0.999	0.000
M89.80 Other specified disorders of bone (Multiple sites)	0.001	0.999	0.000
B17.1 Acute hepatitis C	0.001	0.999	0.000
D16.9 Bone and articular cartilage, unspecified	0.000	0.999	0.001
J92.0 Pleural plaque with presence of asbestos	0.000	0.999	0.001
K83.8 Other specified diseases of biliary tract	0.001	0.999	0.000
Q24.9 Congenital malformation of the heart, unspecified	0.000	0.999	0.001
Q76.4 Other congenital malformations of spine, not associated with scoliosis	0.000	0.999	0.001
S27.3 Other injuries of lung	0.000	0.999	0.001
S40.0 Contusion of shoulder and upper arm	0.000	0.999	0.001
W29.8 Other specified place	0.001	0.999	0.000
W29.6 Industrial and construction area	0.001	0.999	0.000
W29.0 Home	0.001	0.999	0.000
W29.7 Farm	0.001	0.999	0.000
W29.4 Street and highway	0.001	0.999	0.000
W29.3 Sports and athletics area	0.001	0.999	0.000
W29.2 School, other institution and public administrative area	0.001	0.999	0.000
W29.1 Residential institution	0.001	0.999	0.000
V48 Car occupant injured in noncollision transport accident	0.000	0.999	0.001
M21.39 Wrist or foot drop (acquired)-Site unspec	0.001	0.999	0.000
M21.38 Wrist or foot drop (acquired)-Other	0.001	0.999	0.000
M21.36 Wrist or foot drop (acquired)-Lower leg	0.001	0.999	0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations