TreeWAS – Variant ID: rs2738446

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	Risk posterior probability	No effect posterior probability	Protective posterior probability
E78.0 Pure hypercholesterolaemia	1.000	0.000	0.000
T36-T50 Poisoning by drugs, medicaments and biological substances	0.990	0.010	0.000
T44 Poisoning by drugs primarily affecting the autonomic nervous system	0.981	0.019	0.000
T43 Poisoning by psychotropic drugs, not elsewhere classified	0.979	0.021	0.000
I25 Chronic ischaemic heart disease	0.972	0.028	0.000
I25.1 Atherosclerotic heart disease	0.970	0.030	0.000
T42 Poisoning by antiepileptic, sedative-hypnotic and anti-Parkinsonism drugs	0.969	0.031	0.000
I25.2 Old myocardial infarction	0.969	0.031	0.000
T42.4 Benzodiazepines	0.962	0.038	0.000
T43.2 Other and unspecified antidepressants	0.959	0.041	0.000
T44.7 Beta-Adrenoreceeptor antagonists, not elsewhere classified	0.958	0.042	0.000
T39 Poisoning by nonopioid analgesics, antipyretics and antirheumatics	0.944	0.056	0.000
I20-I25 Ischaemic heart diseases	0.944	0.056	0.000
T39.1 4-Aminophenol derivatives	0.911	0.089	0.000
I22 Subsequent myocardial infarction	0.909	0.091	0.000
T47 Poisoning by agents primarily affecting gastro-intestinal system	0.901	0.099	0.000
T43.5 Other and unspecified antipsychotics and neuroleptics	0.891	0.109	0.000
I25.3 Aneurysm of heart	0.871	0.129	0.000
I20 Angina pectoris	0.867	0.133	0.000
I22.9 Subsequent myocardial infarction of unspecified site	0.865	0.135	0.000
I22.0 Subsequent myocardial infarction of anterior wall	0.863	0.137	0.000
T43.3 Phenothiazine antipsychotics and neuroleptics	0.859	0.141	0.000
T44.3 Other parasympatholytics [anticholinergics and antimuscarines] and spasmolytics, not elsewhere classified	0.838	0.162	0.000
I25.5 Ischaemic cardiomyopathy	0.834	0.166	0.000
I20.0 Unstable angina	0.824	0.176	0.000
T46 Poisoning by agents primarily affecting the cardiovascular system	0.822	0.178	0.000
T43.6 Psychostimulants with abuse potential	0.789	0.211	0.000
T50 Poisoning by diuretics and other and unspecified drugs, medicaments and biological substances	0.774	0.226	0.000
I23 Certain current complications following acute myocardial infarction	0.772	0.227	0.000
T44.6 Alpha-Adrenoreceeptor antagonists, not elsewhere classified	0.771	0.229	0.000
T44.9 Other and unspecified drugs primarily affecting the nervous system	0.771	0.229	0.000
I20.1 Angina pectoris with documented spasm	0.764	0.236	0.000
T49 Poisoning by topical agents primarily affecting skin and mucous membrane and by ophthalmological, otorhinolarygological and dental drugs	0.762	0.238	0.000
T37 Poisoning by other systemic anti-infectives and antiparasitics	0.760	0.240	0.000
T48 Poisoning by agents primarily acting on smooth and skeletal muscles and the respiratory system	0.755	0.245	0.000
T38 Poisoning by hormones and their synthetic substitutes and antagonists, not elsewhere classified	0.753	0.246	0.000
T46.6 Antihyperlipidaemic and antiarteriosclerotic drugs	0.751	0.249	0.000
T40 Poisoning by narcotics and psychodysleptics [hallucinogens]	0.748	0.252	0.000
T47.1 Other antacids and anti-gastric-secretion drugs	0.747	0.253	0.000
T43.9 Psychotropic drug, unspecified	0.741	0.259	0.000
T39.0 Salicylates	0.737	0.263	0.000
T47.6 Antidiarrhoeal drugs	0.728	0.272	0.000
T39.8 Other nonopioid analgesics and antipyretics, not elsewhere classified	0.726	0.274	0.000
T42.8 Anti-Parkinsonism drugs and other central muscle-tone depressants	0.713	0.287	0.000
T42.7 Antiepileptic and sedative-hypnotic drugs, unspecified	0.711	0.289	0.000
T41 Poisoning by anaesthetics and therapeutic gases	0.710	0.290	0.000
T47.2 Stimulant laxatives	0.709	0.291	0.000
T45 Poisoning by primarily systemic and haematological agents, not elsewhere classified	0.708	0.292	0.000
T42.3 Barbiturates	0.707	0.293	0.000
T44.8 Centrally acting and afrenergic-neuron-blocking agents, not elsewhere classified	0.703	0.297	0.000
T44.5 Predominantly Beta-adrenoreceptor agonists, not elsewhere classified	0.703	0.297	0.000
T44.4 Predominantly Alpha-adrenoreceptor agonists, not elsewhere classified	0.703	0.297	0.000
T44.2 Ganglionic blocking drugs, not elsewhere classified	0.703	0.297	0.000
T44.1 Other parasympathomimetics [cholinergics]	0.703	0.297	0.000
T44.0 Anticholinesterase agents	0.703	0.297	0.000
T43.8 Other psychotropic drugs, not elsewhere classified	0.702	0.298	0.000
T42.5 Mixed antiepileptics, not elsewhere classified	0.695	0.305	0.000
T42.2 Succinimides and oxazolidinediones	0.695	0.305	0.000
T47.4 Other laxatives	0.684	0.316	0.000
T39.4 Antirheumatics, not elsewhere classified	0.677	0.323	0.000
T39.2 Pyrazolone derivatives	0.677	0.323	0.000
I25.0 Atherosclerotic cardiovascular disease, so described	0.671	0.329	0.000
I24 Other acute ischaemic heart diseases	0.668	0.332	0.000
T47.0 Histamine H(2)-receptor antagonists	0.662	0.338	0.000
I23.8 Other current complications following acute myocardial infarction	0.650	0.350	0.000
T47.9 Agent primarily affecting the gastro-intestinal system, unspecified	0.646	0.354	0.000
T47.8 Other agents primarily affecting the gastro-intestinal system	0.646	0.354	0.000
T47.7 Emetics	0.646	0.354	0.000
T47.5 Digestants	0.646	0.354	0.000
T47.3 Saline and osmotic laxatives	0.646	0.354	0.000
T43.4 Butyrophenone and thioxanthene neuroleptics	0.638	0.362	0.000
T46.3 Coronary vasodilators, not elsewhere classified	0.632	0.368	0.000
T50.2 Carbonic-anhydrase inhibitors, benzothiadiazides and other diuretics	0.630	0.370	0.000
T39.9 Nonopioid analgesic, antipyretic and antirheumatic, unspecified	0.627	0.373	0.000
I20.9 Angina pectoris, unspecified	0.627	0.373	0.000
I25.6 Silent myocardial ischaemia	0.626	0.374	0.000
T42.6 Other antiepileptic and sedative-hypnotic drugs	0.624	0.376	0.000
T42.1 Iminostilbenes	0.619	0.381	0.000
I25.8 Other forms of chronic ischaemic heart disease	0.613	0.387	0.000
T37.2 Antimalarials and drugs acting on other blood protozoa	0.612	0.388	0.000
T50.6 Antidotes and chelating agents, not elsewhere classified	0.608	0.392	0.000
T36 Poisoning by systemic antibiotics	0.605	0.395	0.000
T43.1 Monoamine-oxidase-inhibitor antidepressants	0.601	0.399	0.000
T49.0 Local antifungal, anti-infective and anti-inflammatory drugs, not elsewhere classified	0.598	0.402	0.000
T50.9 Other and unspecified drugs, medicaments and biological substances	0.598	0.402	0.000
T48.6 Antiasthmatics, not elsewhere classified	0.595	0.405	0.000
I21 Acute myocardial infarction	0.595	0.405	0.000
T38.6 Antigonadotrophins. antioestrogens, antiandrogens, not elsewhere classified	0.594	0.406	0.000
I21.9 Acute myocardial infarction, unspecified	0.594	0.406	0.000
T46.9 Other and unspecified agents primarily affecting the cardiovascular system	0.589	0.411	0.000
T46.8 Antivaricose drugs, including sclerosing agents	0.589	0.411	0.000
T46.7 Peripheral vasodilators	0.589	0.411	0.000
T46.2 Other antidysrhythmic drugs, not elsewhere classified	0.589	0.411	0.000
T46.0 Cardiac-stimulant glycosides and drugs of similar action	0.589	0.411	0.000
T45.0 Antiallergic and antiemetic drugs	0.589	0.411	0.000
T39.3 Other nonsteroidal anti-inflammatory drugs [NSAID]	0.588	0.412	0.000
T40.4 Other synthetic narcotics	0.575	0.425	0.000
I25.4 Coronary artery aneurysm	0.575	0.425	0.000
I22.8 Subsequent myocardial infarction of other sites	0.574	0.426	0.000
T46.1 Calcium-channel blockers	0.570	0.430	0.000
T40.5 Cocaine	0.570	0.430	0.000
T40.1 Heroin	0.567	0.433	0.000
T38.1 Thyroid hormones and substitutes	0.563	0.437	0.000
T42.0 Hydantoin derivatives	0.561	0.439	0.000
T50.7 Analeptics and opioid receptor antagonists	0.555	0.445	0.000
T50.5 Appetite depressants	0.555	0.445	0.000
T50.3 Electrolytic, caloric and water-balance agents	0.555	0.445	0.000
T50.1 Loop [high-ceiling] diuretics	0.555	0.445	0.000
T50.0 Mineralocorticoids and their antagonists	0.555	0.445	0.000
I23.6 Thrombosis of atrium, auricular appendage and ventricle as current complications following acute myocardial infarction	0.554	0.446	0.000
I23.5 Rupture of papillary muscle as current complication following acute myocardial infarction	0.554	0.446	0.000
I23.4 Rupture of chordae tendineae as current complication following acute myocardial infarction	0.554	0.446	0.000
I23.3 Rupture of cardiac wall without haemopericardium as current complication following acute myocardial infarction	0.554	0.446	0.000
I23.2 Ventricular septal defect as current complication following acute myocardial infarction	0.554	0.446	0.000
I23.1 Atrial septal defect as current complication following acute myocardial infarction	0.554	0.446	0.000
I23.0 Haemopericardium as current complication following acute myocardial infarction	0.554	0.446	0.000
I24.9 Acute ischaemic heart disease, unspecified	0.552	0.448	0.000
I24.0 Coronary thrombosis not resulting in myocardial infarction	0.548	0.452	0.000
T49.9 Topical agent, unspecified	0.546	0.454	0.000
T49.8 Other topical agents	0.546	0.454	0.000
T49.7 Dental drugs, topically applied	0.546	0.454	0.000
T49.6 Otorhinolaryngological drugs and preparations	0.546	0.454	0.000
T49.5 Ophthalmological drugs and preparations	0.546	0.454	0.000
T49.4 Keratolytics, keratoplastics and other hair treatment drugs and preparations	0.546	0.454	0.000
T49.3 Emollients, demulcents and protectants	0.546	0.454	0.000
T49.2 Local astringents and local detergents	0.546	0.454	0.000
T49.1 Antipruritics	0.546	0.454	0.000
T37.9 Systemic anti-infective and antiparasitic, unspecified	0.545	0.455	0.000
T37.5 Antiviral drugs	0.545	0.455	0.000
T37.4 Anthelminthics	0.545	0.455	0.000
T37.3 Other antiprotozoal drugs	0.545	0.455	0.000
T37.1 Antimycobacterial drugs	0.545	0.455	0.000
T37.0 Sulphonamides	0.545	0.455	0.000
T48.7 Other and unspecified agents primarily acting on the respiratory system	0.541	0.459	0.000
T48.4 Expectorants	0.541	0.459	0.000
T48.3 Antitussives	0.541	0.459	0.000
T48.2 Other and unspecified agents primarily acting on muscles	0.541	0.459	0.000
T48.1 Skeletal muscle relaxants [neuromuscular blocking agents]	0.541	0.459	0.000
T48.0 Oxytocic drugs	0.541	0.459	0.000
T38.9 Other and unspecified hormone antagonists	0.540	0.460	0.000
T38.7 Androgens and anabolic congeners	0.540	0.460	0.000
T38.5 Other oestrogens and progestogens	0.540	0.460	0.000
T38.4 Oral contraceptives	0.540	0.460	0.000
T38.2 Antithyroid drugs	0.540	0.460	0.000
T38.0 Glucocorticoids and synthetic analogues	0.540	0.460	0.000
T40.9 Other and unspecified psychodysleptics [hallucinogens]	0.536	0.464	0.000
T40.8 Lysergide [LSD]	0.536	0.464	0.000
T40.7 Cannabis (derivatives)	0.536	0.464	0.000
T40.3 Methadone	0.536	0.464	0.000
T40.0 Opium	0.536	0.464	0.000
T38.3 Insulin and oral hypoglycaemic [antidiabetic] drugs	0.532	0.468	0.000
T48.5 Anti-common-cold drugs	0.530	0.470	0.000
I73.9 Peripheral vascular disease, unspecified	0.523	0.477	0.000
T37.8 Other specified systemic anti-infectives and antiparasitics	0.521	0.479	0.000
T46.5 Other antihypertensive drugs, not elsewhere classified	0.521	0.479	0.000
T38.8 Other and unspecified hormones and their synthetic substitutes	0.509	0.491	0.000
T41.5 Therapeutic gases	0.509	0.491	0.000
T41.4 Anaesthetic, unspecified	0.509	0.491	0.000
T41.3 Local anaesthetics	0.509	0.491	0.000
T41.2 Other and unspecified general anaesthetics	0.509	0.491	0.000
T41.1 Intravenous anaesthetics	0.509	0.491	0.000
T41.0 Inhaled anaesthetics	0.509	0.491	0.000
T40.2 Other opioids	0.508	0.492	0.000
T45.9 Primarily systemic and haematological agent, unspecified	0.507	0.492	0.000
T45.8 Other primarily systemic and haematological agents	0.507	0.492	0.000
T45.7 Anticoagulant antagonists, vitamin K and other coagulants	0.507	0.492	0.000
T45.6 Fibrinolysis-affecting drugs	0.507	0.492	0.000
T45.4 Iron and its compounds	0.507	0.492	0.000
T45.3 Enzymes, not elsewhere classified	0.507	0.492	0.000
T50.4 Drugs affecting uric acid metabolism	0.505	0.495	0.000
T45.2 Vitamins, not elsewhere classified	0.487	0.513	0.000
T40.6 Other and unspecified narcotics	0.486	0.514	0.000
I24.1 Dressler's syndrome	0.486	0.514	0.000
T46.4 Angiotensin-converting-enzyme inhibitors	0.476	0.524	0.000
T36.3 Macrolides	0.475	0.525	0.000
T45.5 Anticoagulants	0.474	0.526	0.000
T50.8 Diagnostic agents	0.459	0.541	0.000
T36.8 Other systemic antibiotics	0.457	0.542	0.000
T45.1 Antineoplastic and immunosuppressive drugs	0.443	0.557	0.000
T36.9 Systemic antibiotic, unspecified	0.434	0.566	0.000
T36.7 Antifungal antibiotics, systemically used	0.434	0.566	0.000
T36.6 Rifamycins	0.434	0.566	0.000
T36.5 Aminoglycosides	0.434	0.566	0.000
T36.2 Chloramphenicol group	0.434	0.566	0.000
T36.1 Cefalosporins and other Beta-lactam antibiotics	0.434	0.566	0.000
I21.X Presumed acute myicardial infaction (unconfirmed)	0.426	0.573	0.000
T36.4 Tetracyclines	0.388	0.612	0.000
I73 Other peripheral vascular diseases	0.380	0.620	0.000
I70-I79 Diseases of arteries, arterioles and capillaries	0.346	0.654	0.000
Chapter IX Diseases of the circulatory system	0.319	0.681	0.000
I21.2 Acute transmural myocardial infarction of other sites	0.319	0.681	0.000
I25.9 Chronic ischaemic heart disease, unspecified	0.296	0.704	0.000
I72 Other aneurysm	0.295	0.705	0.000
I79 Disorders of arteries, arterioles and capillaries in diseases classified elsewhere	0.293	0.707	0.000
I21.3 Acute transmural myocardial infarction of unspecified site	0.287	0.713	0.000
I22.1 Subsequent myocardial infarction of inferior wall	0.284	0.715	0.001
I73.1 Thromboangiitis obliterans [Buerger]	0.281	0.719	0.000
I72.9 Aneurysm of unspecified site	0.279	0.721	0.000
I73.8 Other specified peripheral vascular diseases	0.275	0.725	0.000
T36.0 Penicillins	0.273	0.726	0.001
I77 Other disorders of arteries and arterioles	0.269	0.731	0.000
I77.1 Stricture of artery	0.261	0.739	0.000
I00-I02 Acute rheumatic fever	0.261	0.739	0.000
I74 Arterial embolism and thrombosis	0.258	0.742	0.000
I83.9 Varicose veins of lower extremities without ulcer or inflammation	0.239	0.761	0.000
I83 Varicose veins of lower extremities	0.239	0.761	0.000
I79.8 Other disorders of arteries, arterioles and capillaries in diseases classified elsewhere	0.238	0.762	0.000
I21.0 Acute transmural myocardial infarction of anterior wall	0.238	0.762	0.000
I80-I89 Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified	0.238	0.762	0.000
I79.2 Peripheral angiopathy in diseases classified elsewhere	0.235	0.765	0.000
I72.2 Aneurysm of renal artery	0.231	0.769	0.000
I74.1 Embolism and thrombosis of other and unspecified parts of aorta	0.224	0.776	0.000
I77.2 Rupture of artery	0.223	0.777	0.000
I72.4 Aneurysm of artery of lower extremity	0.221	0.779	0.000
I00 Rheumatic fever without mention of heart involvement	0.219	0.781	0.000
I72.6 Aneurysm and dissection of vertebral artery	0.212	0.788	0.000
I72.5 Aneurysm and dissection of other precerebral arteries	0.212	0.788	0.000
I79.1 Aortitis in diseases classified elsewhere	0.210	0.790	0.000
I79.0 Aneurysm of aorta in diseases classified elsewhere	0.210	0.790	0.000
I83.1 Varicose veins of lower extremities with inflammation	0.207	0.793	0.000
I70 Atherosclerosis	0.207	0.793	0.000
I82 Other venous embolism and thrombosis	0.206	0.794	0.000
T43.0 Tricyclic and tetracyclic antidepressants	0.205	0.795	0.000
I74.3 Embolism and thrombosis of arteries of the lower extremities	0.204	0.796	0.000
I81 Portal vein thrombosis	0.204	0.796	0.000
I74.2 Embolism and thrombosis of arteries of the upper extremities	0.198	0.802	0.000
I74.0 Embolism and thrombosis of abdominal aorta	0.194	0.805	0.000
I74.4 Embolism and thrombosis of arteries of extremities, unspecified	0.193	0.807	0.000
I77.5 Necrosis of artery	0.193	0.807	0.000
I77.4 Coeliac artery compression syndrome	0.193	0.807	0.000
I72.8 Aneurysm of other specified arteries	0.193	0.807	0.000
I77.3 Arterial fibromuscular dysplasia	0.189	0.811	0.000
I83.2 Varicose veins of lower extremities with both ulcer and inflammation	0.188	0.812	0.000
I82.9 Embolism and thrombosis of unspecified vein	0.188	0.812	0.000
I02 Rheumatic chorea	0.187	0.813	0.000
I01 Rheumatic fever with heart involvement	0.187	0.813	0.000
I72.0 Aneurysm of carotid artery	0.185	0.815	0.000
I72.3 Aneurysm of iliac artery	0.183	0.817	0.000
I71 Aortic aneurysm and dissection	0.180	0.820	0.000
I77.9 Disorder of arteries and arterioles, unspecified	0.176	0.824	0.000
I70.0 Atherosclerosis of aorta	0.174	0.826	0.000
I72.1 Aneurysm of artery of upper extremity	0.172	0.827	0.000
I88 Nonspecific lymphadenitis	0.170	0.830	0.000
I71.0 Dissection of aorta [any part]	0.164	0.836	0.000
I78 Diseases of capillaries	0.160	0.840	0.000
I82.0 Budd-Chiari syndrome	0.157	0.843	0.000
I82.2 Embolism and thrombosis of vena cava	0.156	0.844	0.000
I74.5 Embolism and thrombosis of iliac artery	0.155	0.845	0.000
I82.3 Embolism and thrombosis of renal vein	0.154	0.846	0.000
I70.00 Atherosclerosis of aorta (without gangrene)	0.150	0.850	0.000
I86 Varicose veins of other sites	0.149	0.851	0.000
I74.9 Embolism and thrombosis of unspecified artery	0.149	0.851	0.000
I82.1 Thrombophlebitis migrans	0.148	0.852	0.000
I77.8 Other specified disorders of arteries and arterioles	0.143	0.857	0.000
I70.1 Atherosclerosis of renal artery	0.140	0.860	0.000
I70.8 Atherosclerosis of other arteries	0.139	0.861	0.000
I24.8 Other forms of acute ischaemic heart disease	0.139	0.861	0.000
I87 Other disorders of veins	0.139	0.861	0.000
I77.0 Arteriovenous fistula, acquired	0.139	0.861	0.000
I71.1 Thoracic aortic aneurysm, ruptured	0.137	0.863	0.000
I70.9 Generalised and unspecified atherosclerosis	0.135	0.865	0.000
I01.9 Acute rheumatic heart disease, unspecified	0.134	0.865	0.000
I01.8 Other acute rheumatic heart disease	0.134	0.865	0.000
I01.2 Acute rheumatic myocarditis	0.134	0.865	0.000
I01.1 Acute rheumatic endocarditis	0.134	0.865	0.000
I01.0 Acute rheumatic pericarditis	0.134	0.865	0.000
I02.9 Rheumatic chorea without heart involvement	0.134	0.865	0.000
I02.0 Rheumatic chorea with heart involvement	0.134	0.865	0.000
I71.6 Thoracoabdominal aortic aneurysm, without mention of rupture	0.134	0.866	0.000
I88.0 Nonspecific mesenteric lymphadenitis	0.131	0.869	0.000
I88.8 Other nonspecific lymphadenitis	0.130	0.870	0.000
I71.8 Aortic aneurysm of unspecified site, ruptured	0.129	0.871	0.000
I71.5 Thoracoabdominal aortic aneurysm, ruptured	0.129	0.871	0.000
I74.8 Embolism and thrombosis of other arteries	0.127	0.873	0.000
I89 Other non-infective disorders of lymphatic vessels and lymph nodes	0.125	0.875	0.000
I70.01 Atherosclerosis of aorta (with gangrene)	0.125	0.875	0.000
I71.4 Abdominal aortic aneurysm, without mention of rupture	0.125	0.875	0.000
I88.1 Chronic lymphadenitis, except mesenteric	0.122	0.878	0.000
I20.8 Other forms of angina pectoris	0.117	0.883	0.000
I78.8 Other diseases of capillaries	0.115	0.885	0.000
I87.0 Postphlebitic syndrome	0.112	0.887	0.000
I86.2 Pelvic varices	0.112	0.888	0.000
I86.8 Varicose veins of other specified sites	0.110	0.890	0.000
I78.9 Disease of capillaries, unspecified	0.107	0.893	0.000
I86.4 Gastric varices	0.107	0.893	0.000
I86.0 Sublingual varices	0.107	0.893	0.000
I71.3 Abdominal aortic aneurysm, ruptured	0.104	0.896	0.000
I83.0 Varicose veins of lower extremities with ulcer	0.103	0.897	0.000
I87.9 Disorder of vein, unspecified	0.103	0.897	0.000
I78.0 Hereditary haemorrhagic telangiectasia	0.102	0.898	0.000
I10-I15 Hypertensive diseases	0.101	0.899	0.000
I88.9 Nonspecific lymphadenitis, unspecified	0.101	0.899	0.000
I70.11 Atherosclerosis of renal artery (with gangrene)	0.100	0.899	0.000
I70.81 Atherosclerosis of other arteries (with gangrene)	0.100	0.900	0.000
I70.2 Atherosclerosis of arteries of the extremities	0.100	0.900	0.000
I89.0 Lymphoedema, not elsewhere classified	0.099	0.901	0.000
I70.91 Generalized and unspecified atherosclerosis (with gangrene)	0.097	0.903	0.000
I82.8 Embolism and thrombosis of other specified veins	0.097	0.903	0.000
I86.3 Vulval varices	0.097	0.903	0.000
I89.1 Lymphangitis	0.094	0.905	0.000
I70.10 Atherosclerosis of renal artery (without gangrene)	0.092	0.908	0.000
I70.80 Atherosclerosis of other arteries (without gangrene)	0.091	0.909	0.000
I26-I28 Pulmonary heart disease and diseases of pulmonary circulation	0.089	0.910	0.000
I87.2 Venous insufficiency (chronic) (peripheral)	0.089	0.911	0.000
C34.3 Lower lobe, bronchus or lung	0.000	0.911	0.089
I95-I99 Other and unspecified disorders of the circulatory system	0.088	0.912	0.000
I87.1 Compression of vein	0.087	0.913	0.000
I86.1 Scrotal varices	0.087	0.913	0.000
I21.4 Acute subendocardial myocardial infarction	0.086	0.914	0.000
I21.1 Acute transmural myocardial infarction of inferior wall	0.084	0.916	0.000
I70.90 Generalized and unspecified atherosclerosis (without gangrene)	0.083	0.916	0.000
I85 Oesophageal varices	0.081	0.918	0.000
I89.9 Non-infective disorder of lymphatic vessels and lymph nodes, unspecified	0.081	0.919	0.000
I11 Hypertensive heart disease	0.077	0.923	0.000
I97 Postprocedural disorders of circulatory system, not elsewhere classified	0.077	0.923	0.000
C34 Malignant neoplasm of bronchus and lung	0.000	0.923	0.077
E78 Disorders of lipoprotein metabolism and other lipidaemias	0.077	0.923	0.000
I05-I09 Chronic rheumatic heart diseases	0.076	0.924	0.000
I15 Secondary hypertension	0.074	0.926	0.000
I70.21 Atherosclerosis of arteries of extremities (with gangrene)	0.074	0.926	0.000
I87.8 Other specified disorders of veins	0.073	0.927	0.000
I13 Hypertensive heart and renal disease	0.073	0.927	0.000
C34.0 Main bronchus	0.000	0.928	0.072
I97.1 Other functional disturbances following cardiac surgery	0.070	0.930	0.000
I78.1 Naevus, nonneoplastic	0.070	0.930	0.000
I11.9 Hypertensive heart disease without (congestive) heart failure	0.067	0.933	0.000
I28 Other diseases of pulmonary vessels	0.066	0.934	0.000
I77.6 Arteritis, unspecified	0.065	0.935	0.000
I71.9 Aortic aneurysm of unspecified site, without mention of rupture	0.063	0.937	0.000
I15.0 Renovascular hypertension	0.061	0.939	0.000
C30-C39 Malignant neoplasms of respiratory and intrathoracic organs	0.000	0.940	0.060
C34.9 Bronchus or lung, unspecified	0.000	0.940	0.060
I97.2 Postmastectomy lymphoedema syndrome	0.059	0.941	0.000
C34.2 Middle lobe, bronchus or lung	0.000	0.942	0.058
E78.6 Lipoprotein deficiency	0.057	0.942	0.000
C32 Malignant neoplasm of larynx	0.000	0.944	0.056
E78.3 Hyperchylomicronaemia	0.056	0.944	0.000
I06 Rheumatic aortic valve diseases	0.056	0.944	0.000
I97.9 Postprocedural disorder of circulatory system, unspecified	0.055	0.945	0.000
I97.0 Postcardiotomy syndrome	0.055	0.945	0.000
E78.4 Other hyperlipidaemia	0.055	0.945	0.000
I15.9 Seconday hypertension, unspecified	0.055	0.945	0.000
E78.1 Pure hyperglyceridaemia	0.054	0.945	0.000
I15.2 Hypertension secondary to endocrine disorders	0.054	0.946	0.000
I15.8 Other secondary hypertension	0.054	0.946	0.000
C32.0 Glottis	0.000	0.946	0.054
C34.8 Overlapping lesion of bronchus and lung	0.000	0.947	0.053
I13.9 Hypertensive heart and renal disease, unspecified	0.052	0.948	0.000
I13.2 Hypertensive heart and renal disease with both (congestive) heart failure and renal failure	0.052	0.948	0.000
I13.1 Hypertensive heart and renal disease with renal failure	0.052	0.948	0.000
I13.0 Hypertensive heart and renal disease with (congestive) heart failure	0.052	0.948	0.000
I09 Other rheumatic heart diseases	0.050	0.950	0.000
I28.8 Other specified diseases of pulmonary vessels	0.048	0.951	0.000
I28.9 Disease of pulmonary vessels, unspecified	0.047	0.953	0.000
I28.1 Aneurysm of pulmonary artery	0.047	0.953	0.000
I28.0 Arteriovenous fistula of pulmonary vessels	0.047	0.953	0.000
I97.8 Other postprocedural disorders of circulatory system, not elsewhere classified	0.046	0.953	0.000
C37 Malignant neoplasm of thymus	0.000	0.954	0.046
I71.2 Thoracic aortic aneurysm, without mention of rupture	0.046	0.954	0.000
C32.9 Larynx, unspecified	0.000	0.954	0.046
I12 Hypertensive renal disease	0.046	0.954	0.000
C38 Malignant neoplasm of heart, mediastinum and pleura	0.000	0.955	0.045
C31 Malignant neoplasm of accessory sinuses	0.000	0.955	0.045
E78.2 Mixed hyperlipidaemia	0.044	0.956	0.000
I85.0 Oesophageal varices with bleeding	0.044	0.956	0.000
C33 Malignant neoplasm of trachea	0.000	0.956	0.044
I07 Rheumatic tricuspid valve diseases	0.044	0.956	0.000
C39 Malignant neoplasm of other and ill-defined sites in the respiratory system and intrathoracic organs	0.000	0.957	0.043
N75.1 Abscess of Bartholin's gland	0.043	0.957	0.000
I06.9 Rheumatic aortic valve disease, unspecified	0.042	0.957	0.000
I06.2 Rheumatic aortic stenosis with insufficiency	0.042	0.958	0.000
I06.0 Rheumatic aortic stenosis	0.042	0.958	0.000
I11.0 Hypertensive heart disease with (congestive) heart failure	0.042	0.958	0.000
E78.9 Disorder of lipoprotein metabolism, unspecified	0.042	0.958	0.000
C32.8 Overlapping lesion of larynx	0.000	0.959	0.041
C32.3 Laryngeal cartilage	0.000	0.959	0.041
C32.2 Subglottis	0.000	0.959	0.041
I06.8 Other rheumatic aortic valve diseases	0.040	0.960	0.000
I08 Multiple valve diseases	0.040	0.960	0.000
I08.1 Disorders of both mitral and tricuspid valves	0.040	0.960	0.000
I15.1 Hypertension secondary to other renal disorders	0.039	0.961	0.000
I98 Other disorders of circulatory system in diseases classified elsewhere	0.038	0.962	0.000
E78.8 Other disorders of lipoprotein metabolism	0.037	0.962	0.000
I09.8 Other specified rheumatic heart diseases	0.036	0.964	0.000
I09.2 Chronic rheumatic pericarditis	0.036	0.964	0.000
I09.1 Rheumatic diseases of endocardium, valve unspecified	0.036	0.964	0.000
I09.0 Rheumatic myocarditis	0.036	0.964	0.000
C30 Malignant neoplasm of nasal cavity and middle ear	0.000	0.964	0.036
I51.9 Heart disease, unspecified	0.036	0.964	0.000
C38.3 Mediastinum, part unspecified	0.000	0.965	0.035
I06.1 Rheumatic aortic insufficiency	0.034	0.965	0.000
C31.0 Maxillary sinus	0.000	0.965	0.034
C32.1 Supraglottis	0.000	0.966	0.034
I26 Pulmonary embolism	0.034	0.966	0.000
I12.9 Hypertensive renal disease without renal failure	0.034	0.966	0.000
I08.9 Multiple valve disease, unspecified	0.033	0.967	0.000
C38.4 Pleura	0.000	0.967	0.033
C38.8 Overlapping lesion of heart, mediastinum and pleura	0.000	0.967	0.033
C38.2 Posterior mediastinum	0.000	0.967	0.033
C38.1 Anterior mediastinum	0.000	0.967	0.033
C38.0 Heart	0.000	0.967	0.033
C31.9 Accessory sinus, unspecified	0.000	0.967	0.032
C31.8 Overlapping lesion of accessory sinuses	0.000	0.967	0.032
C31.3 Sphenoidal sinus	0.000	0.967	0.032
C31.2 Frontal sinus	0.000	0.967	0.032
C31.1 Ethmoidal sinus	0.000	0.967	0.032
I73.0 Raynaud's syndrome	0.032	0.968	0.000
I07.9 Tricuspid valve disease, unspecified	0.031	0.968	0.000
I07.8 Other tricuspid valve diseases	0.031	0.968	0.000
I07.2 Tricuspid stenosis with insufficiency	0.031	0.968	0.000
I07.0 Tricuspid stenosis	0.031	0.968	0.000
I09.9 Rheumatic heart disease, unspecified	0.031	0.969	0.000
C39.9 Ill-defined sites within the respiratory system	0.000	0.969	0.031
C39.8 Overlapping lesion of respiratory and intrathoracic organs	0.000	0.969	0.031
C39.0 Upper respiratory tract, part unspecified	0.000	0.969	0.031
I99 Other and unspecified disorders of circulatory system	0.029	0.971	0.000
N75 Diseases of Bartholin's gland	0.029	0.971	0.000
I98.8 Other specified disorders of circulatory system in diseases classified elsewhere	0.028	0.972	0.000
I98.1 Cardiovascular disorders in other infectious and parasitic diseases classified elsewhere	0.028	0.972	0.000
I98.0 Cardiovascular syphilis	0.028	0.972	0.000
I60-I69 Cerebrovascular diseases	0.028	0.972	0.000
I61 Intracerebral haemorrhage	0.027	0.973	0.000
I98.3 Oesophageal varices with bleeding in diseases classified elsewhere	0.026	0.974	0.000
C30.1 Middle ear	0.000	0.974	0.026
N75.0 Cyst of Bartholin's gland	0.026	0.974	0.000
I89.8 Other specified non-infective disorders of lymphatic vessels and lymph nodes	0.024	0.974	0.002
I61.5 Intracerebral haemorrhage, intraventricular	0.024	0.976	0.000
I61.3 Intracerebral haemorrhage in brain stem	0.024	0.976	0.000
I61.4 Intracerebral haemorrhage in cerebellum	0.023	0.977	0.000
I61.0 Intracerebral haemorrhage in hemisphere, subcortical	0.023	0.977	0.000
I61.1 Intracerebral haemorrhage in hemisphere, cortical	0.023	0.977	0.000
I61.6 Intracerebral haemorrhage, multiple localised	0.022	0.977	0.000
I26.0 Pulmonary embolism with mention of acute cor pulmonale	0.022	0.978	0.000
D18.0 Haemangioma, any site	0.022	0.978	0.000
N75.8 Other diseases of Bartholin's gland	0.022	0.978	0.000
I07.1 Tricuspid insufficiency	0.021	0.979	0.000
N75.9 Disease of Bartholin's gland, unspecified	0.021	0.979	0.000
I65 Occlusion and stenosis of precerebral arteries, not resulting in cerebral infarction	0.021	0.979	0.000
E70-E90 Metabolic disorders	0.020	0.980	0.000
C30.0 Nasal cavity	0.000	0.981	0.018
I65.3 Occlusion and stenosis of multiple and bilateral precerebral arteries	0.018	0.982	0.000
I62 Other nontraumatic intracranial haemorrhage	0.018	0.982	0.000
I08.8 Other multiple valve diseases	0.018	0.982	0.000
I61.2 Intracerebral haemorrhage in hemisphere, unspecified	0.018	0.982	0.000
I08.2 Disorders of both aortic and tricuspid valves	0.018	0.982	0.000
I66 Occlusion and stenosis of cerebral arteries, not resulting in cerebral infarction	0.018	0.982	0.000
E73 Lactose intolerance	0.018	0.982	0.000
I70.20 Atherosclerosis of arteries of extremities (without gangrene)	0.017	0.982	0.001
I68 Cerebrovascular disorders in diseases classified elsewhere	0.017	0.983	0.000
E84 Cystic fibrosis	0.017	0.983	0.000
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified	0.017	0.983	0.000
I65.0 Occlusion and stenosis of vertebral artery	0.017	0.983	0.000
I65.8 Occlusion and stenosis of other precerebral artery	0.017	0.983	0.000
E73.9 Lactose intolerance, unspecified	0.017	0.983	0.000
Y83.4 Other reconstructive surgery	0.016	0.984	0.000
E74 Other disorders of carbohydrate metabolism	0.016	0.984	0.000
I62.9 Intracranial haemorrhage (nontraumatic), unspecified	0.016	0.984	0.000
E70 Disorders of aromatic amino-acid metabolism	0.015	0.985	0.000
I65.9 Occlusion and stenosis of unspecified precerebral artery	0.015	0.985	0.000
I60 Subarachnoid haemorrhage	0.015	0.985	0.000
E88 Other metabolic disorders	0.015	0.985	0.000
E79 Disorders of purine and pyrimidine metabolism	0.015	0.985	0.000
E89.3 Postprocedural hypopituitarism	0.015	0.985	0.000
E72 Other disorders of amino-acid metabolism	0.015	0.985	0.000
I61.8 Other intracerebral haemorrhage	0.015	0.985	0.000
E89.5 Postprocedural testicular hypofunction	0.015	0.985	0.000
E77 Disorders of glycoprotein metabolism	0.014	0.985	0.000
E76 Disorders of glycosaminoglycan metabolism	0.014	0.985	0.000
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism	0.014	0.985	0.000
E90 Nutritional and metabolic disorders in diseases classified elsewhere	0.014	0.985	0.000
E84.9 Cystic fibrosis, unspecified	0.014	0.986	0.000
I08.0 Disorders of both mitral and aortic valves	0.014	0.986	0.000
E84.0 Cystic fibrosis with pulmonary manifestations	0.014	0.986	0.000
E89.4 Postprocedural ovarian failure	0.014	0.986	0.000
I05 Rheumatic mitral valve diseases	0.013	0.986	0.001
E89.6 Postprocedural adrenocortical(-medullary) hypofunction	0.014	0.986	0.000
I65.1 Occlusion and stenosis of basilar artery	0.014	0.986	0.000
C34.1 Upper lobe, bronchus or lung	0.000	0.986	0.014
I66.8 Occlusion and stenosis of other cerebral artery	0.013	0.987	0.000
I66.2 Occlusion and stenosis of posterior cerebral artery	0.013	0.987	0.000
I66.1 Occlusion and stenosis of anterior cerebral artery	0.013	0.987	0.000
I66.0 Occlusion and stenosis of middle cerebral artery	0.013	0.987	0.000
E73.8 Other lactose intolerance	0.013	0.987	0.000
E73.1 Secondary lactase deficiency	0.013	0.987	0.000
E73.0 Congenital lactase deficiency	0.013	0.987	0.000
I66.3 Occlusion and stenosis of cerebellar arteries	0.013	0.987	0.000
E83 Disorders of mineral metabolism	0.013	0.987	0.000
E89.8 Other postprocedural endocrine and metabolic disorders	0.013	0.987	0.000
E89.2 Postprocedural hypoparathyroidism	0.013	0.987	0.000
I66.9 Occlusion and stenosis of unspecified cerebral artery	0.013	0.987	0.000
I68.8 Other cerebrovascular disorders in diseases classified elsewhere	0.012	0.987	0.000
I68.2 Cerebral arteritis in other diseases classified elsewhere	0.012	0.987	0.000
I68.1 Cerebral arteritis in infectious and parasitic diseases classified elsewhere	0.012	0.987	0.000
E84.8 Cystic fibrosis with other manifestations	0.013	0.987	0.000
E84.1 Cystic fibrosis with intestinal manifestations	0.013	0.987	0.000
E89.9 Postprocedural endocrine and metabolic disorder, unspecified	0.013	0.987	0.000
I85.9 Oesophageal varices without bleeding	0.012	0.987	0.000
I60.0 Subarachnoid haemorrhage from carotid siphon and bifurcation	0.013	0.987	0.000
E80 Disorders of porphyrin and bilirubin metabolism	0.013	0.987	0.000
I60.1 Subarachnoid haemorrhage from middle cerebral artery	0.013	0.987	0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations