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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs2765219
log Bayes Factor = 52.865
Chromosome 6   position 28,770,349  (GRCh37) Explore rs2765219 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E83.1 Disorders of iron metabolism
1.000 0.000 0.000
K90.0 Coeliac disease
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
E05.9 Thyrotoxicosis, unspecified
0.000 0.001 0.999
E10.9 Without complications
0.000 0.002 0.998
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.004 0.996
E10-E14 Diabetes mellitus
0.000 0.004 0.996
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.006 0.994
E16.2 Hypoglycaemia, unspecified
0.000 0.006 0.994
E16 Other disorders of pancreatic internal secretion
0.000 0.006 0.994
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.006 0.994
E10.3 With ophthalmic complications
0.000 0.007 0.993
E00-E07 Disorders of thyroid gland
0.000 0.009 0.991
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.057 0.943
E10.2 With renal complications
0.000 0.065 0.935
E10.1 With ketoacidosis
0.000 0.083 0.917
E10.4 With neurological complications
0.000 0.112 0.888
I83.9 Varicose veins of lower extremities without ulcer or inflammation
0.858 0.142 0.000
E13 Other specified diabetes mellitus
0.000 0.173 0.827
E05.8 Other thyrotoxicosis
0.000 0.187 0.813
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.210 0.790
E16.1 Other hypoglycaemia
0.000 0.222 0.778
E10.7 With multiple complications
0.000 0.250 0.749
E10.0 With coma
0.000 0.277 0.723
E05.5 Thyroid crisis or storm
0.000 0.286 0.714
E05.4 Thyrotoxicosis factitia
0.000 0.286 0.714
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.286 0.714
E12 Malnutrition-related diabetes mellitus
0.000 0.286 0.714
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.287 0.712
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.287 0.712
E16.4 Abnormal secretion of gastrin
0.000 0.287 0.712
E16.3 Increased secretion of glucagon
0.000 0.287 0.712
E15 Nondiabetic hypoglycaemic coma
0.000 0.288 0.712
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.289 0.711
E00 Congenital iodine-deficiency syndrome
0.000 0.289 0.711
E13.9 Without complications
0.000 0.296 0.704
E40-E46 Malnutrition
0.000 0.306 0.694
E14 Unspecified diabetes mellitus
0.000 0.310 0.690
E10.6 With other specified complications
0.000 0.358 0.642
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.364 0.636
E07 Other disorders of thyroid
0.000 0.377 0.623
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.394 0.606
E13.3 With ophthalmic complications
0.000 0.402 0.598
E10.5 With peripheral circulatory complications
0.000 0.407 0.593
E13.8 With unspecified complications
0.000 0.407 0.593
E13.7 With multiple complications
0.000 0.407 0.593
E13.6 With other specified complications
0.000 0.407 0.593
E13.5 With peripheral circulatory complications
0.000 0.407 0.593
E13.4 With neurological complications
0.000 0.407 0.593
E13.2 With renal complications
0.000 0.407 0.593
E13.1 With ketoacidosis
0.000 0.407 0.593
E13.0 With coma
0.000 0.407 0.593
E06 Thyroiditis
0.000 0.411 0.589
E14.3 With ophthalmic complications
0.000 0.421 0.579
E14.1 With ketoacidosis
0.000 0.443 0.557
E14.6 With other specified complications
0.000 0.475 0.525
E14.4 With neurological complications
0.000 0.486 0.514
E12.9 Without complications
0.000 0.488 0.512
E12.8 With unspecified complications
0.000 0.488 0.512
E12.7 With multiple complications
0.000 0.488 0.512
E12.6 With other specified complications
0.000 0.488 0.512
E12.5 With peripheral circulatory complications
0.000 0.488 0.512
E12.4 With neurological complications
0.000 0.488 0.512
E12.3 With ophthalmic complications
0.000 0.488 0.512
E12.2 With renal complications
0.000 0.488 0.512
E12.1 With ketoacidosis
0.000 0.488 0.512
E12.0 With coma
0.000 0.488 0.512
E10.8 With unspecified complications
0.000 0.490 0.510
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.000 0.490 0.510
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.000 0.490 0.510
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.000 0.490 0.510
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.000 0.490 0.510
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.490 0.510
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.000 0.490 0.510
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.000 0.490 0.510
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.000 0.490 0.510
E14.8 With unspecified complications
0.000 0.499 0.501
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.502 0.498
E45 Retarded development following protein-energy malnutrition
0.000 0.502 0.498
E43 Unspecified severe protein-energy malnutrition
0.000 0.502 0.498
E42 Marasmic kwashiorkor
0.000 0.502 0.498
E41 Nutritional marasmus
0.000 0.502 0.498
E40 Kwashiorkor
0.000 0.502 0.498
E14.7 With multiple complications
0.000 0.505 0.494
E07.8 Other specified disorders of thyroid
0.000 0.506 0.494
E46 Unspecified protein-energy malnutrition
0.000 0.521 0.479
E06.9 Thyroiditis, unspecified
0.000 0.523 0.477
E14.2 Withrenal complications
0.000 0.528 0.472
E14.5 With peripheral circulatory complications
0.000 0.532 0.467
E14.0 With coma
0.000 0.537 0.463
E07.1 Dyshormogenetic goitre
0.000 0.553 0.447
E07.0 Hypersecretion of calcitonin
0.000 0.553 0.447
E06.1 Subacute thyroiditis
0.000 0.557 0.443
E06.4 Drug-induced thyroiditis
0.000 0.578 0.422
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.578 0.422
E06.0 Acute thyroiditis
0.000 0.578 0.422
E06.5 Other chronic thyroiditis
0.000 0.594 0.405
K90 Intestinal malabsorption
0.000 0.597 0.403
E11 Non-insulin-dependent diabetes mellitus
0.000 0.611 0.389
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.001 0.612 0.387
E03 Other hypothyroidism
0.000 0.613 0.387
E11.6 With other specified complications
0.000 0.640 0.360
E44.1 Mild protein-energy malnutrition
0.000 0.643 0.357
E44.0 Moderate protein-energy malnutrition
0.000 0.643 0.357
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.000 0.656 0.344
E11.1 With ketoacidosis
0.000 0.664 0.336
E11.0 With coma
0.000 0.668 0.332
E65-E68 Obesity and other hyperalimentation
0.000 0.689 0.311
E50-E64 Other nutritional deficiencies
0.000 0.691 0.309
C19 Malignant neoplasm of rectosigmoid junction
0.000 0.702 0.298
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.710 0.289
K90.3 Pancreatic steatorrhoea
0.000 0.711 0.289
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.711 0.289
K90.1 Tropical sprue
0.000 0.711 0.289
E11.2 With renal complications
0.000 0.715 0.285
E11.7 With multiple complications
0.000 0.721 0.279
E03.5 Myxoedema coma
0.000 0.723 0.277
E03.4 Atrophy of thyroid (acquired)
0.000 0.723 0.277
E03.3 Postinfectious hypothyroidism
0.000 0.723 0.277
K90.8 Other intestinal malabsorption
0.000 0.723 0.277
E03.1 Congenital hypothyroidism without goitre
0.000 0.733 0.267
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.733 0.267
E07.9 Disorder of thyroid, unspecified
0.000 0.739 0.261
E03.8 Other specified hypothyroidism
0.000 0.763 0.237
E54 Ascorbic acid deficiency
0.000 0.774 0.225
E67 Other hyperalimentation
0.000 0.777 0.223
E68 Sequelae of hyperalimentation
0.000 0.777 0.223
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.778 0.222
E63 Other nutritional deficiencies
0.000 0.778 0.222
E50 Vitamin A deficiency
0.000 0.778 0.222
E60 Dietary zinc deficiency
0.000 0.778 0.222
E59 Dietary selenium deficiency
0.000 0.778 0.222
E52 Niacin deficiency [pellagra]
0.000 0.778 0.222
E51 Thiamine deficiency
0.000 0.779 0.221
E11.8 With unspecified complications
0.000 0.780 0.220
E56 Other vitamin deficiencies
0.000 0.790 0.210
C15-C26 Malignant neoplasms of digestive organs
0.000 0.798 0.202
E11.5 With peripheral circulatory complications
0.000 0.798 0.201
I83 Varicose veins of lower extremities
0.200 0.800 0.000
E55 Vitamin D deficiency
0.000 0.800 0.200
C20 Malignant neoplasm of rectum
0.000 0.801 0.199
C15 Malignant neoplasm of oesophagus
0.000 0.803 0.197
E20-E35 Disorders of other endocrine glands
0.000 0.804 0.196
E58 Dietary calcium deficiency
0.000 0.807 0.193
K90.9 Intestinal malabsorption, unspecified
0.000 0.820 0.180
C25 Malignant neoplasm of pancreas
0.000 0.821 0.179
E83 Disorders of mineral metabolism
0.157 0.822 0.021
E24 Cushing's syndrome
0.000 0.823 0.177
C15.4 Middle third of oesophagus
0.000 0.827 0.173
C15.5 Lower third of oesophagus
0.000 0.830 0.170
M45.X9 Ankylosing spondylitis (Site unspecified)
0.167 0.833 0.000
C15.9 Oesophagus, unspecified
0.000 0.834 0.166
E67.8 Other specified hyperalimentation
0.000 0.840 0.160
E67.3 Hypervitaminosis D
0.000 0.840 0.160
E67.2 Megavitamin-B6 syndrome
0.000 0.840 0.160
E67.1 Hypercarotenaemia
0.000 0.840 0.160
E67.0 Hypervitaminosis A
0.000 0.840 0.160
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.000 0.840 0.160
E61 Deficiency of other nutrient elements
0.000 0.840 0.160
E50.9 Vitamin A deficiency, unspecified
0.000 0.841 0.159
E50.8 Other manifestations of vitamin A deficiency
0.000 0.841 0.159
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.841 0.159
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.841 0.159
E50.5 Vitamin A deficiency with night blindness
0.000 0.841 0.159
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.841 0.159
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.841 0.159
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.841 0.159
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.841 0.159
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.841 0.159
E63.9 Nutritional deficiency, unspecified
0.000 0.841 0.159
E63.8 Other specified nutritional deficiencies
0.000 0.841 0.159
E63.1 Imbalance of constituents of food intake
0.000 0.841 0.159
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.841 0.159
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.841 0.159
E64.8 Sequelae of other nutritional deficiencies
0.000 0.841 0.159
E64.3 Sequelae of rickets
0.000 0.841 0.159
E64.2 Sequelae of vitamin C deficiency
0.000 0.841 0.159
E64.1 Sequelae of vitamin A deficiency
0.000 0.841 0.159
E64.0 Sequelae of protein-energy malnutrition
0.000 0.841 0.159
E65 Localised adiposity
0.000 0.841 0.159
E14.9 Without complications
0.000 0.841 0.159
E51.9 Thiamine deficiency, unspecified
0.000 0.841 0.158
E51.8 Other manifestations of thiamine deficiency
0.000 0.841 0.158
E51.1 Beriberi
0.000 0.841 0.158
E51.2 Wernicke's encephalopathy
0.000 0.843 0.157
E53 Deficiency of other B group vitamins
0.000 0.845 0.155
C15.0 Cervical part of oesophagus
0.000 0.847 0.152
C25.2 Tail of pancreas
0.000 0.848 0.152
E21.3 Hyperparathyroidism, unspecified
0.000 0.849 0.151
E56.9 Vitamin deficiency, unspecified
0.000 0.849 0.150
E56.8 Deficiency of other vitamins
0.000 0.849 0.150
E56.0 Deficiency of vitamin E
0.000 0.849 0.150
E28 Ovarian dysfunction
0.000 0.850 0.150
I83.0 Varicose veins of lower extremities with ulcer
0.150 0.850 0.000
C17 Malignant neoplasm of small intestine
0.000 0.851 0.149
C25.3 Pancreatic duct
0.000 0.851 0.149
C15.3 Upper third of oesophagus
0.000 0.851 0.149
E24.9 Cushing's syndrome, unspecified
0.000 0.852 0.148
E20 Hypoparathyroidism
0.000 0.853 0.147
E24.0 Pituitary-dependent Cushing's disease
0.000 0.853 0.147
C25.1 Body of pancreas
0.000 0.854 0.146
E06.3 Autoimmune thyroiditis
0.001 0.856 0.143
C25.4 Endocrine pancreas
0.000 0.856 0.144
E55.0 Rickets, active
0.000 0.856 0.143
C15.1 Thoracic part of oesophagus
0.000 0.856 0.143
C15.8 Overlapping lesion of oesophagus
0.000 0.858 0.142
C15.2 Abdominal part of oesophagus
0.000 0.858 0.142
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.859 0.141
E32 Diseases of thymus
0.000 0.859 0.141
E30 Disorders of puberty, not elsewhere classified
0.000 0.859 0.141
C17.0 Duodenum
0.000 0.859 0.141
E25 Adrenogenital disorders
0.000 0.860 0.140
C25.8 Overlapping lesion of pancreas
0.000 0.860 0.140
C24 Malignant neoplasm of other and unspecified parts of biliary tract
0.000 0.861 0.139
E31 Polyglandular dysfunction
0.000 0.861 0.138
E56.1 Deficiency of vitamin K
0.000 0.862 0.138
E83.3 Disorders of phosphorus metabolism
0.131 0.863 0.006
E24.2 Drug-induced Cushing's syndrome
0.000 0.867 0.133
C25.9 Pancreas, unspecified
0.000 0.867 0.133
C21 Malignant neoplasm of anus and anal canal
0.000 0.872 0.128
E24.8 Other Cushing's syndrome
0.000 0.872 0.128
E83.8 Other disorders of mineral metabolism
0.113 0.872 0.015
E83.2 Disorders of zinc metabolism
0.113 0.872 0.015
E83.0 Disorders of copper metabolism
0.113 0.872 0.015
E83.9 Disorder of mineral metabolism, unspecified
0.112 0.873 0.015
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.000 0.873 0.127
E24.3 Ectopic ACTH syndrome
0.000 0.873 0.127
E24.1 Nelson's syndrome
0.000 0.873 0.127
C24.0 Extrahepatic bile duct
0.000 0.878 0.122
E29 Testicular dysfunction
0.000 0.878 0.122
E28.2 Polycystic ovarian syndrome
0.000 0.879 0.121
E55.9 Vitamin D deficiency, unspecified
0.000 0.879 0.121
I83.2 Varicose veins of lower extremities with both ulcer and inflammation
0.118 0.882 0.000
C25.7 Other parts of pancreas
0.000 0.883 0.117
E21.2 Other hyperparathyroidism
0.000 0.885 0.115
E21.4 Other specified disorders of parathyroid gland
0.000 0.885 0.115
E61.9 Deficiency of nutrient element, unspecified
0.000 0.885 0.115
E61.8 Deficiency of other specified nutrient elements
0.000 0.885 0.115
E61.7 Deficiency of multiple nutrient elements
0.000 0.885 0.115
E61.6 Vanadium deficiency
0.000 0.885 0.115
E61.5 Molybdenum deficiency
0.000 0.885 0.115
E61.4 Chromium deficiency
0.000 0.885 0.115
E61.3 Manganese deficiency
0.000 0.885 0.115
E61.0 Copper deficiency
0.000 0.885 0.115
E53.9 Vitamin B deficiency, unspecified
0.000 0.886 0.114
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.000 0.887 0.112
E20.9 Hypoparathyroidism, unspecified
0.000 0.888 0.112
E53.1 Pyridoxine deficiency
0.000 0.889 0.111
E53.0 Riboflavin deficiency
0.000 0.889 0.111
E34 Other endocrine disorders
0.000 0.889 0.111
E11.3 With ophthalmic complications
0.000 0.890 0.110
E28.9 Ovarian dysfunction, unspecified
0.000 0.892 0.108
E28.8 Other ovarian dysfunction
0.000 0.892 0.108
E28.1 Androgen excess
0.000 0.892 0.108
E28.0 Oestrogen excess
0.000 0.892 0.108
C17.8 Overlapping lesion of small intestine
0.000 0.893 0.107
C17.3 Meckel's diverticulum
0.000 0.893 0.107
E20.8 Other hypoparathyroidism
0.000 0.894 0.106
E20.1 Pseudohypoparathyroidism
0.000 0.894 0.106
E20.0 Idiopathic hypoparathyroidism
0.000 0.894 0.106
E28.3 Primary ovarian failure
0.000 0.898 0.102
E30.9 Disorder of puberty, unspecified
0.000 0.899 0.101
E30.8 Other disorders of puberty
0.000 0.899 0.101
E30.1 Precocious puberty
0.000 0.899 0.101
E30.0 Delayed puberty
0.000 0.899 0.101
E32.9 Disease of thymus, unspecified
0.000 0.899 0.101
E32.8 Other diseases of thymus
0.000 0.899 0.101
E32.1 Abscess of thymus
0.000 0.899 0.101
E32.0 Persistent hyperplasia of thymus
0.000 0.899 0.101
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.899 0.101
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.899 0.101
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.899 0.101
E61.2 Magnesium deficiency
0.000 0.899 0.101
E25.9 Adrenogenital disorder, unspecified
0.000 0.899 0.101
E25.8 Other adrenogenital disorders
0.000 0.899 0.101
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.000 0.900 0.100
C24.8 Overlapping lesion of biliary tract
0.000 0.900 0.100
E31.9 Polyglandular dysfunction, unspecified
0.000 0.900 0.099
E31.8 Other polyglandular dysfunction
0.000 0.900 0.099
E31.1 Polyglandular hyperfunction
0.000 0.900 0.099
C21.8 Overlapping lesion of rectum, anus and anal canal
0.000 0.900 0.099
E31.0 Autoimmune polyglandular failure
0.000 0.903 0.097
E70-E90 Metabolic disorders
0.002 0.904 0.095
C17.1 Jejunum
0.000 0.904 0.095
C23 Malignant neoplasm of gallbladder
0.000 0.905 0.094
E21.5 Disorder of parathyroid gland, unspecified
0.000 0.906 0.093
E26 Hyperaldosteronism
0.000 0.907 0.092
C21.2 Cloacogenic zone
0.000 0.908 0.092
C26 Malignant neoplasm of other and ill-defined digestive organs
0.000 0.909 0.091
C24.9 Biliary tract, unspecified
0.000 0.910 0.090
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.000 0.910 0.090
E29.9 Testicular dysfunction, unspecified
0.000 0.911 0.089
E03.9 Hypothyroidism, unspecified
0.000 0.911 0.089
E29.8 Other testicular dysfunction
0.000 0.912 0.088
E29.0 Testicular hyperfunction
0.000 0.912 0.088
E78.2 Mixed hyperlipidaemia
0.000 0.912 0.088
E11.4 With neurological complications
0.000 0.915 0.085
C22 Malignant neoplasm of liver and intrahepatic bile ducts
0.000 0.919 0.081
E34.3 Short stature, not elsewhere classified
0.000 0.919 0.081
C21.0 Anus, unspecified
0.000 0.920 0.080
E34.5 Androgen resistance syndrome
0.000 0.920 0.080
E34.4 Constitutional tall stature
0.000 0.920 0.080
E34.2 Ectopic hormone secretion, not elsewhere classified
0.000 0.920 0.080
E34.1 Other hypersecretion of intestinal hormones
0.000 0.920 0.080
M45 Ankylosing spondylitis
0.079 0.921 0.000
E78.1 Pure hyperglyceridaemia
0.000 0.921 0.079
C21.1 Anal canal
0.000 0.921 0.078
E21.0 Primary hyperparathyroidism
0.000 0.921 0.078
E23 Hypofunction and other disorders of pituitary gland
0.000 0.923 0.077
E61.1 Iron deficiency
0.000 0.923 0.077
E88 Other metabolic disorders
0.001 0.924 0.076
E22 Hyperfunction of pituitary gland
0.000 0.924 0.076
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.001 0.925 0.074
E78.5 Hyperlipidaemia, unspecified
0.000 0.925 0.075
E34.8 Other specified endocrine disorders
0.000 0.925 0.074
E74 Other disorders of carbohydrate metabolism
0.001 0.926 0.073
E34.9 Endocrine disorder, unspecified
0.000 0.927 0.073
E78.6 Lipoprotein deficiency
0.000 0.927 0.073
C17.9 Small intestine, unspecified
0.000 0.929 0.071
C17.2 Ileum
0.000 0.930 0.070
I83.1 Varicose veins of lower extremities with inflammation
0.070 0.930 0.000
E84 Cystic fibrosis
0.001 0.930 0.069
E77 Disorders of glycoprotein metabolism
0.001 0.931 0.068
E76 Disorders of glycosaminoglycan metabolism
0.001 0.931 0.068
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.001 0.931 0.068
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.001 0.931 0.068
E83.4 Disorders of magnesium metabolism
0.061 0.931 0.008
E73 Lactose intolerance
0.001 0.931 0.068
E78.3 Hyperchylomicronaemia
0.000 0.932 0.068
E23.7 Disorder of pituitary gland, unspecified
0.000 0.933 0.067
E29.1 Testicular hypofunction
0.000 0.933 0.067
E79 Disorders of purine and pyrimidine metabolism
0.001 0.933 0.065
E26.8 Other hyperaldosteronism
0.000 0.933 0.066
E26.1 Secondary hyperaldosteronism
0.000 0.933 0.066
E85 Amyloidosis
0.001 0.934 0.065
E34.0 Carcinoid syndrome
0.000 0.934 0.066
E88.9 Metabolic disorder, unspecified
0.000 0.934 0.066
E70 Disorders of aromatic amino-acid metabolism
0.001 0.934 0.065
C26.8 Overlapping lesion of digestive system
0.000 0.934 0.065
C26.1 Spleen
0.000 0.934 0.065
E72 Other disorders of amino-acid metabolism
0.001 0.937 0.062
E78.9 Disorder of lipoprotein metabolism, unspecified
0.000 0.938 0.061
M45.X6 Ankylosing spondylitis (Lumbar region)
0.061 0.939 0.000
M45.X2 Ankylosing spondylitis (Cervical region)
0.061 0.939 0.000
E88.2 Lipomatosis, not elsewhere classified
0.000 0.940 0.060
E75.5 Other lipid storage disorders
0.001 0.940 0.059
E74.3 Other disorders of intestinal carbohydrate absorption
0.001 0.941 0.058
C22.7 Other specified carcinomas of liver
0.000 0.941 0.058
C22.4 Other sarcomas of liver
0.000 0.941 0.058
C22.3 Angiosarcoma of liver
0.000 0.941 0.058
C22.2 Hepatoblastoma
0.000 0.941 0.058
E26.9 Hyperaldosteronism, unspecified
0.001 0.941 0.058
E88.1 Lipodystrophy, not elsewhere classified
0.000 0.942 0.058
C25.0 Head of pancreas
0.000 0.942 0.058
E78.4 Other hyperlipidaemia
0.000 0.942 0.058
R31 Unspecified haematuria
0.058 0.942 0.000
M45.X8 Ankylosing spondylitis (Sacral and sacrococcygeal region)
0.057 0.943 0.000
M45.X7 Ankylosing spondylitis (Lumbosacral region)
0.057 0.943 0.000
M45.X5 Ankylosing spondylitis (Thoracolumbar region)
0.057 0.943 0.000
M45.X4 Ankylosing spondylitis (Thoracic region)
0.057 0.943 0.000
M45.X3 Ankylosing spondylitis (Cervicothoracic region)
0.057 0.943 0.000
M45.X1 Ankylosing spondylitis (Occipito-atlanto-axial region)
0.057 0.943 0.000
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.000 0.944 0.056
E23.1 Drug-induced hypopituitarism
0.000 0.944 0.056
E75.2 Other sphingolipidosis
0.001 0.945 0.054
E22.8 Other hyperfunction of pituitary gland
0.000 0.945 0.055
C24.1 Ampulla of Vater
0.001 0.945 0.054
C22.9 Liver, unspecified
0.000 0.945 0.054
E75.6 Lipid storage disorder, unspecified
0.001 0.946 0.053
E75.4 Neuronal ceroid lipofuscinosis
0.001 0.946 0.053
E75.3 Sphingolipidosis, unspecified
0.001 0.946 0.053
E75.1 Other gangliosidosis
0.001 0.946 0.053
E75.0 GM2 gangliosidosis
0.001 0.946 0.053
C22.1 Intrahepatic bile duct carcinoma
0.000 0.946 0.054
E74.9 Disorder of carbohydrate metabolism, unspecified
0.001 0.947 0.052
E74.8 Other specified disorders of carbohydrate metabolism
0.001 0.947 0.052
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
0.001 0.947 0.052
E74.2 Disorders of galactose metabolism
0.001 0.947 0.052
E74.1 Disorders of fructose metabolism
0.001 0.947 0.052
E85.4 Organ-limited amyloidosis
0.001 0.947 0.052
E22.1 Hyperprolactinaemia
0.000 0.948 0.052
E74.0 Glycogen storage disease
0.001 0.948 0.051
E88.8 Other specified metabolic disorders
0.001 0.948 0.051
E84.0 Cystic fibrosis with pulmonary manifestations
0.001 0.949 0.051
E84.8 Cystic fibrosis with other manifestations
0.001 0.950 0.049
E84.1 Cystic fibrosis with intestinal manifestations
0.001 0.950 0.049
E84.9 Cystic fibrosis, unspecified
0.001 0.950 0.049
E71.3 Disorders of fatty-acid metabolism
0.001 0.950 0.049
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified
0.001 0.950 0.049
E71.1 Other disorders of branched-chain amino-acid metabolism
0.001 0.950 0.049
E71.0 Maple-syrup-urine disease
0.001 0.950 0.049
E76.9 Disorder of glucosaminoglycan metabolism, unspecified
0.001 0.950 0.049
E76.8 Other disorders of glucosaminoglycan metabolism
0.001 0.950 0.049
E76.3 Mucopolysaccharidosis, unspecified
0.001 0.950 0.049
E76.2 Other mucopolysaccharidoses
0.001 0.950 0.049
E76.1 Mucopolysaccharidosis, type II
0.001 0.950 0.049
E76.0 Mucopolysaccharidosis, type I
0.001 0.950 0.049
E77.9 Disorder of glycoprotein metabolism, unspecified
0.001 0.950 0.049
E77.8 Other disorders of glycoprotein metabolism
0.001 0.950 0.049
E77.1 Defects in glycoprotein degradation
0.001 0.950 0.049
E77.0 Defects in posttranslational modification of lysosomal enzymes
0.001 0.950 0.049
E85.3 Secondary systemic amyloidosis
0.001 0.950 0.049
E73.8 Other lactose intolerance
0.001 0.950 0.049
E73.1 Secondary lactase deficiency
0.001 0.950 0.049
E73.0 Congenital lactase deficiency
0.001 0.950 0.049
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.951 0.049
E73.9 Lactose intolerance, unspecified
0.001 0.951 0.048
E88.0 Disorders of plasma-protein metabolism, not elsewhere classified
0.000 0.951 0.049
E79.9 Disorder of purine and pyrimidine metabolism, unspecified
0.001 0.952 0.047
E79.8 Other disorders of purine and pyrimidine metabolism
0.001 0.952 0.047
E79.1 Lesch-Nyhan syndrome
0.001 0.952 0.047
E85.8 Other amyloidosis
0.001 0.952 0.047
E85.2 Heredofamilial amyloidosis, unspecified
0.001 0.952 0.047
E85.1 Neuropathic heredofamilial amyloidosis
0.001 0.952 0.047
E85.0 Nonneuropathic heredofamilial amyloidosis
0.001 0.952 0.047
E70.9 Disorder of aromatic amino-acid metabolism, unspecified
0.001 0.952 0.046
E70.8 Other disorders of aromatic amino-acid metabolism
0.001 0.952 0.046
E70.2 Disorders of tyrosine metabolism
0.001 0.952 0.046
E70.1 Other hyperphenylalaninaemias
0.001 0.952 0.046
E70.0 Classical phenylketonuria
0.001 0.952 0.046
C26.9 Ill-defined sites within the digestive system
0.001 0.953 0.046
E04 Other non-toxic goitre
0.002 0.954 0.044
E72.9 Disorder of amino-acid metabolism, unspecified
0.001 0.954 0.044
E72.8 Other specified disorders of amino-acid metabolism
0.001 0.954 0.044
E72.5 Disorders of glycine metabolism
0.001 0.954 0.044
E72.4 Disorders of ornithine metabolism
0.001 0.954 0.044
E72.3 Disorders of lysine and hydroxylysine metabolism
0.001 0.954 0.044
E72.2 Disorders of urea cycle metabolism
0.001 0.954 0.044
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
0.001 0.954 0.044
C26.0 Intestinal tract, part unspecified
0.000 0.955 0.045
E88.3 Tumour lysis syndrome
0.001 0.955 0.045
M45.X0 Ankylosing spondylitis (Multiple sites in spine)
0.044 0.955 0.000
E72.0 Disorders of amino-acid transport
0.001 0.956 0.043
E70.3 Albinism
0.001 0.956 0.043
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.000 0.957 0.043
I80-I89 Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified
0.042 0.958 0.000
C18 Malignant neoplasm of colon
0.000 0.959 0.041
E72.1 Disorders of sulphur-bearing amino-acid metabolism
0.001 0.959 0.040
C18.1 Appendix
0.000 0.960 0.040
E23.6 Other disorders of pituitary gland
0.000 0.960 0.039
E23.2 Diabetes insipidus
0.000 0.961 0.038
C18.9 Colon, unspecified
0.000 0.962 0.038
E80 Disorders of porphyrin and bilirubin metabolism
0.001 0.962 0.037
E22.0 Acromegaly and pituitary gigantism
0.000 0.963 0.037
E78.8 Other disorders of lipoprotein metabolism
0.000 0.963 0.037
I86 Varicose veins of other sites
0.037 0.963 0.000
I89 Other non-infective disorders of lymphatic vessels and lymph nodes
0.037 0.963 0.000
E53.8 Deficiency of other specified B group vitamins
0.000 0.964 0.036
E26.0 Primary hyperaldosteronism
0.001 0.964 0.035
I86.8 Varicose veins of other specified sites
0.034 0.966 0.000
I81 Portal vein thrombosis
0.034 0.966 0.000
I89.9 Non-infective disorder of lymphatic vessels and lymph nodes, unspecified
0.033 0.967 0.000
E04.8 Other specified non-toxic goitre
0.002 0.967 0.032
I89.0 Lymphoedema, not elsewhere classified
0.032 0.968 0.000
I85 Oesophageal varices
0.032 0.968 0.000
E85.9 Amyloidosis, unspecified
0.001 0.970 0.029
E78.0 Pure hypercholesterolaemia
0.000 0.970 0.030
C16 Malignant neoplasm of stomach
0.000 0.970 0.030
C18.8 Overlapping lesion of colon
0.000 0.970 0.030
I86.4 Gastric varices
0.030 0.970 0.000
E80.2 Other porphyria
0.001 0.971 0.028
I89.1 Lymphangitis
0.029 0.971 0.000
I82 Other venous embolism and thrombosis
0.028 0.972 0.000
E27 Other disorders of adrenal gland
0.000 0.972 0.028
I86.3 Vulval varices
0.028 0.972 0.000
I86.2 Pelvic varices
0.027 0.972 0.000
E80.7 Disorder of bilirubin metabolism, unspecified
0.001 0.973 0.026
E80.5 Crigler-Najjar syndrome
0.001 0.973 0.026
E80.3 Defects of catalase and peroxydase
0.001 0.973 0.026
E80.0 Hereditary erythropoietic porphyria
0.001 0.973 0.026
I85.9 Oesophageal varices without bleeding
0.027 0.973 0.000
E66 Obesity
0.000 0.973 0.027
I87 Other disorders of veins
0.027 0.973 0.000
I86.0 Sublingual varices
0.027 0.973 0.000
C18.6 Descending colon
0.000 0.974 0.026
E11.9 Without complications
0.000 0.974 0.026
I88 Nonspecific lymphadenitis
0.025 0.975 0.000
K90-K93 Other diseases of the digestive system
0.000 0.975 0.025
C18.4 Transverse colon
0.000 0.976 0.024
E04.0 Non-toxic diffuse goitre
0.002 0.976 0.022
E80.6 Other disorders of bilirubin metabolism
0.001 0.977 0.022
I82.8 Embolism and thrombosis of other specified veins
0.023 0.977 0.000
E80.1 Porphyria cutanea tarda
0.001 0.977 0.022
C18.3 Hepatic flexure
0.000 0.978 0.022
I82.0 Budd-Chiari syndrome
0.022 0.978 0.000
I87.8 Other specified disorders of veins
0.022 0.978 0.000
E83.5 Disorders of calcium metabolism
0.005 0.979 0.016
I77 Other disorders of arteries and arterioles
0.000 0.979 0.021
C16.2 Body of stomach
0.000 0.979 0.021
I77.6 Arteritis, unspecified
0.000 0.979 0.021
M45-M49 Spondylopathies
0.021 0.979 0.000
I82.1 Thrombophlebitis migrans
0.020 0.979 0.000
E27.5 Adrenomedullary hyperfunction
0.000 0.980 0.020
E27.0 Other adrenocortical overactivity
0.000 0.980 0.020
I77.9 Disorder of arteries and arterioles, unspecified
0.000 0.980 0.020
C16.6 Greater curvature of stomach, unspecified
0.000 0.980 0.020
E23.0 Hypopituitarism
0.000 0.980 0.020
I73.9 Peripheral vascular disease, unspecified
0.000 0.980 0.020
E66.1 Drug-induced obesity
0.000 0.980 0.020
I87.0 Postphlebitic syndrome
0.019 0.980 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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