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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs28360994
log Bayes Factor = 34.9957
Chromosome 6   position 31,186,208  (GRCh37) Explore rs28360994 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E03.9 Hypothyroidism, unspecified
1.000 0.000 0.000
K90.0 Coeliac disease
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.008 0.992
E10-E14 Diabetes mellitus
0.000 0.009 0.991
E10.3 With ophthalmic complications
0.000 0.011 0.989
E11 Non-insulin-dependent diabetes mellitus
0.000 0.023 0.977
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.062 0.938
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.065 0.935
E16.2 Hypoglycaemia, unspecified
0.000 0.065 0.935
E16 Other disorders of pancreatic internal secretion
0.000 0.066 0.934
E11.4 With neurological complications
0.000 0.077 0.923
E13 Other specified diabetes mellitus
0.000 0.094 0.906
E10.2 With renal complications
0.000 0.123 0.877
E11.3 With ophthalmic complications
0.000 0.126 0.874
E13.9 Without complications
0.000 0.155 0.845
E10.4 With neurological complications
0.000 0.156 0.844
M13.99 Arthritis, unspecified (Site unspecified)
0.000 0.157 0.843
E11.8 With unspecified complications
0.000 0.169 0.831
E10.1 With ketoacidosis
0.000 0.176 0.824
E11.5 With peripheral circulatory complications
0.000 0.181 0.819
E11.6 With other specified complications
0.000 0.193 0.807
E65-E68 Obesity and other hyperalimentation
0.000 0.197 0.803
E10.8 With unspecified complications
0.000 0.218 0.782
E11.2 With renal complications
0.000 0.228 0.772
E10.9 Without complications
0.000 0.240 0.760
E14 Unspecified diabetes mellitus
0.000 0.249 0.751
E00-E07 Disorders of thyroid gland
0.024 0.276 0.700
E10.6 With other specified complications
0.000 0.286 0.714
E10.7 With multiple complications
0.000 0.289 0.711
E12 Malnutrition-related diabetes mellitus
0.000 0.289 0.711
E50-E64 Other nutritional deficiencies
0.000 0.290 0.710
E10.0 With coma
0.000 0.292 0.708
E03 Other hypothyroidism
0.479 0.293 0.229
E40-E46 Malnutrition
0.000 0.294 0.705
E11.7 With multiple complications
0.000 0.300 0.700
E11.0 With coma
0.000 0.306 0.694
E14.3 With ophthalmic complications
0.000 0.318 0.682
E11.1 With ketoacidosis
0.000 0.325 0.675
E15 Nondiabetic hypoglycaemic coma
0.000 0.330 0.670
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.330 0.669
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.330 0.669
E16.4 Abnormal secretion of gastrin
0.000 0.330 0.669
E16.3 Increased secretion of glucagon
0.000 0.330 0.669
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.330 0.669
E05 Thyrotoxicosis [hyperthyroidism]
0.003 0.341 0.656
E66 Obesity
0.000 0.341 0.659
E10.5 With peripheral circulatory complications
0.000 0.346 0.654
E65 Localised adiposity
0.000 0.349 0.651
E13.8 With unspecified complications
0.000 0.350 0.650
E13.7 With multiple complications
0.000 0.350 0.650
E13.6 With other specified complications
0.000 0.350 0.650
E13.5 With peripheral circulatory complications
0.000 0.350 0.650
E13.4 With neurological complications
0.000 0.350 0.650
E13.3 With ophthalmic complications
0.000 0.350 0.650
E13.2 With renal complications
0.000 0.350 0.650
E13.1 With ketoacidosis
0.000 0.350 0.650
E13.0 With coma
0.000 0.350 0.650
E16.1 Other hypoglycaemia
0.000 0.382 0.618
E05.0 Thyrotoxicosis with diffuse goitre
0.001 0.392 0.608
E66.8 Other obesity
0.000 0.397 0.603
E06 Thyroiditis
0.011 0.404 0.585
E55 Vitamin D deficiency
0.000 0.410 0.590
E67 Other hyperalimentation
0.000 0.424 0.576
E68 Sequelae of hyperalimentation
0.000 0.424 0.576
E66.0 Obesity due to excess calories
0.000 0.441 0.559
E46 Unspecified protein-energy malnutrition
0.000 0.461 0.539
E14.8 With unspecified complications
0.000 0.461 0.539
E14.7 With multiple complications
0.000 0.461 0.539
E14.5 With peripheral circulatory complications
0.000 0.461 0.539
E14.4 With neurological complications
0.000 0.461 0.539
E14.2 Withrenal complications
0.000 0.461 0.539
E14.1 With ketoacidosis
0.000 0.461 0.539
E14.0 With coma
0.000 0.461 0.539
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.002 0.467 0.531
E06.9 Thyroiditis, unspecified
0.005 0.480 0.515
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.017 0.481 0.502
E00 Congenital iodine-deficiency syndrome
0.017 0.481 0.502
E12.9 Without complications
0.000 0.490 0.510
E12.8 With unspecified complications
0.000 0.490 0.510
E12.7 With multiple complications
0.000 0.490 0.510
E12.6 With other specified complications
0.000 0.490 0.510
E12.5 With peripheral circulatory complications
0.000 0.490 0.510
E12.4 With neurological complications
0.000 0.490 0.510
E12.3 With ophthalmic complications
0.000 0.490 0.510
E12.2 With renal complications
0.000 0.490 0.510
E12.1 With ketoacidosis
0.000 0.490 0.510
E12.0 With coma
0.000 0.490 0.510
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.491 0.509
E63 Other nutritional deficiencies
0.000 0.491 0.509
E56 Other vitamin deficiencies
0.000 0.491 0.509
E51 Thiamine deficiency
0.000 0.491 0.509
E50 Vitamin A deficiency
0.000 0.491 0.509
E60 Dietary zinc deficiency
0.000 0.491 0.509
E59 Dietary selenium deficiency
0.000 0.491 0.509
E58 Dietary calcium deficiency
0.000 0.491 0.509
E54 Ascorbic acid deficiency
0.000 0.491 0.509
E52 Niacin deficiency [pellagra]
0.000 0.491 0.509
E03.5 Myxoedema coma
0.343 0.493 0.164
E03.4 Atrophy of thyroid (acquired)
0.343 0.493 0.164
E03.3 Postinfectious hypothyroidism
0.343 0.493 0.164
E03.1 Congenital hypothyroidism without goitre
0.343 0.493 0.164
E03.0 Congenital hypothyroidism with diffuse goitre
0.343 0.493 0.164
E14.6 With other specified complications
0.000 0.493 0.507
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.494 0.506
E45 Retarded development following protein-energy malnutrition
0.000 0.494 0.506
E43 Unspecified severe protein-energy malnutrition
0.000 0.494 0.506
E42 Marasmic kwashiorkor
0.000 0.494 0.506
E41 Nutritional marasmus
0.000 0.494 0.506
E40 Kwashiorkor
0.000 0.494 0.506
E55.9 Vitamin D deficiency, unspecified
0.000 0.496 0.504
E02 Subclinical iodine-deficiency hypothyroidism
0.017 0.501 0.482
E03.8 Other specified hypothyroidism
0.355 0.505 0.140
E61 Deficiency of other nutrient elements
0.000 0.506 0.494
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.332 0.508 0.160
E05.9 Thyrotoxicosis, unspecified
0.000 0.526 0.474
E05.8 Other thyrotoxicosis
0.002 0.527 0.470
E05.5 Thyroid crisis or storm
0.002 0.527 0.470
E05.4 Thyrotoxicosis factitia
0.002 0.527 0.470
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.002 0.527 0.470
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.002 0.527 0.470
E66.2 Extreme obesity with alveolar hypoventilation
0.000 0.528 0.472
E66.1 Drug-induced obesity
0.000 0.528 0.472
E53 Deficiency of other B group vitamins
0.000 0.543 0.457
K90 Intestinal malabsorption
0.000 0.551 0.449
E06.5 Other chronic thyroiditis
0.008 0.572 0.420
E06.4 Drug-induced thyroiditis
0.008 0.572 0.420
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.008 0.572 0.420
E06.1 Subacute thyroiditis
0.008 0.572 0.420
E06.0 Acute thyroiditis
0.008 0.572 0.420
E55.0 Rickets, active
0.000 0.577 0.423
E67.8 Other specified hyperalimentation
0.000 0.587 0.413
E67.3 Hypervitaminosis D
0.000 0.587 0.413
E67.2 Megavitamin-B6 syndrome
0.000 0.587 0.413
E67.1 Hypercarotenaemia
0.000 0.587 0.413
E67.0 Hypervitaminosis A
0.000 0.587 0.413
E06.3 Autoimmune thyroiditis
0.006 0.604 0.390
E07 Other disorders of thyroid
0.019 0.613 0.368
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.012 0.627 0.360
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.012 0.627 0.360
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.012 0.627 0.360
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.012 0.627 0.360
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.012 0.627 0.360
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.012 0.627 0.360
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.012 0.627 0.360
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.012 0.627 0.360
E50.9 Vitamin A deficiency, unspecified
0.000 0.635 0.365
E50.8 Other manifestations of vitamin A deficiency
0.000 0.635 0.365
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.635 0.365
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.635 0.365
E50.5 Vitamin A deficiency with night blindness
0.000 0.635 0.365
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.635 0.365
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.635 0.365
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.635 0.365
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.635 0.365
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.635 0.365
E51.9 Thiamine deficiency, unspecified
0.000 0.635 0.365
E51.8 Other manifestations of thiamine deficiency
0.000 0.635 0.365
E51.2 Wernicke's encephalopathy
0.000 0.635 0.365
E51.1 Beriberi
0.000 0.635 0.365
E56.9 Vitamin deficiency, unspecified
0.000 0.635 0.365
E56.8 Deficiency of other vitamins
0.000 0.635 0.365
E56.1 Deficiency of vitamin K
0.000 0.635 0.365
E56.0 Deficiency of vitamin E
0.000 0.635 0.365
E63.9 Nutritional deficiency, unspecified
0.000 0.635 0.365
E63.8 Other specified nutritional deficiencies
0.000 0.635 0.365
E63.1 Imbalance of constituents of food intake
0.000 0.635 0.365
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.635 0.365
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.635 0.365
E64.8 Sequelae of other nutritional deficiencies
0.000 0.635 0.365
E64.3 Sequelae of rickets
0.000 0.635 0.365
E64.2 Sequelae of vitamin C deficiency
0.000 0.635 0.365
E64.1 Sequelae of vitamin A deficiency
0.000 0.635 0.365
E64.0 Sequelae of protein-energy malnutrition
0.000 0.635 0.365
E44.1 Mild protein-energy malnutrition
0.000 0.637 0.363
E44.0 Moderate protein-energy malnutrition
0.000 0.637 0.363
E61.9 Deficiency of nutrient element, unspecified
0.000 0.646 0.354
E61.8 Deficiency of other specified nutrient elements
0.000 0.646 0.354
E61.7 Deficiency of multiple nutrient elements
0.000 0.646 0.354
E61.6 Vanadium deficiency
0.000 0.646 0.354
E61.5 Molybdenum deficiency
0.000 0.646 0.354
E61.4 Chromium deficiency
0.000 0.646 0.354
E61.3 Manganese deficiency
0.000 0.646 0.354
E61.2 Magnesium deficiency
0.000 0.646 0.354
E61.0 Copper deficiency
0.000 0.646 0.354
E61.1 Iron deficiency
0.000 0.662 0.338
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.000 0.671 0.329
K90.8 Other intestinal malabsorption
0.000 0.672 0.328
E53.9 Vitamin B deficiency, unspecified
0.000 0.672 0.328
E53.1 Pyridoxine deficiency
0.000 0.672 0.328
E53.0 Riboflavin deficiency
0.000 0.672 0.328
K90.3 Pancreatic steatorrhoea
0.000 0.678 0.322
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.678 0.322
K90.1 Tropical sprue
0.000 0.678 0.322
K90.9 Intestinal malabsorption, unspecified
0.000 0.696 0.304
E14.9 Without complications
0.000 0.711 0.289
E07.8 Other specified disorders of thyroid
0.012 0.714 0.274
M13.9 Arthritis, unspecified
0.000 0.720 0.280
E07.1 Dyshormogenetic goitre
0.013 0.722 0.264
E07.0 Hypersecretion of calcitonin
0.013 0.722 0.264
E53.8 Deficiency of other specified B group vitamins
0.000 0.725 0.275
M13.93 Arthritis, unspecified (Forearm)
0.000 0.780 0.220
M13.96 Arthritis, unspecified (Lower leg)
0.000 0.784 0.216
M13.91 Arthritis, unspecified (Shoulder region)
0.000 0.784 0.216
M13.94 Arthritis, unspecified (Hand)
0.000 0.788 0.212
M13.92 Arthritis, unspecified (Upper arm)
0.000 0.788 0.211
M13.97 Arthritis, unspecified (Ankle and foot)
0.000 0.805 0.195
E04 Other non-toxic goitre
0.009 0.843 0.148
M13.90 Arthritis, unspecified (Multiple sites)
0.000 0.846 0.154
E20-E35 Disorders of other endocrine glands
0.000 0.850 0.150
M13 Other arthritis
0.000 0.853 0.147
E34 Other endocrine disorders
0.000 0.876 0.123
E07.9 Disorder of thyroid, unspecified
0.016 0.878 0.106
M13.0 Polyarthritis, unspecified
0.000 0.881 0.119
E04.0 Non-toxic diffuse goitre
0.006 0.884 0.110
E04.8 Other specified non-toxic goitre
0.007 0.887 0.106
E26 Hyperaldosteronism
0.000 0.888 0.112
E24 Cushing's syndrome
0.000 0.890 0.110
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.892 0.107
E32 Diseases of thymus
0.000 0.892 0.107
E31 Polyglandular dysfunction
0.000 0.892 0.107
E30 Disorders of puberty, not elsewhere classified
0.000 0.892 0.107
E25 Adrenogenital disorders
0.000 0.892 0.107
M13.1 Monoarthritis, not elsewhere classified
0.000 0.892 0.107
M13.95 Arthritis, unspecified (Pelvic region and thigh)
0.000 0.895 0.105
E29 Testicular dysfunction
0.000 0.895 0.105
E22 Hyperfunction of pituitary gland
0.000 0.898 0.101
M13.98 Arthritis, unspecified (Other)
0.000 0.899 0.101
E20 Hypoparathyroidism
0.000 0.900 0.100
M13.09 Polyarthritis, unspecified (Site unspecified)
0.000 0.903 0.096
E34.8 Other specified endocrine disorders
0.000 0.904 0.096
E34.0 Carcinoid syndrome
0.000 0.904 0.096
E34.9 Endocrine disorder, unspecified
0.000 0.906 0.094
M13.00 Polyarthritis, unspecified (Multiple sites)
0.000 0.910 0.090
E34.5 Androgen resistance syndrome
0.000 0.911 0.089
E34.4 Constitutional tall stature
0.000 0.911 0.089
E34.3 Short stature, not elsewhere classified
0.000 0.911 0.089
E34.2 Ectopic hormone secretion, not elsewhere classified
0.000 0.911 0.089
E34.1 Other hypersecretion of intestinal hormones
0.000 0.911 0.089
M13.08 Polyarthritis, unspecified (Other)
0.000 0.914 0.085
M13.07 Polyarthritis, unspecified (Ankle and foot)
0.000 0.914 0.085
M13.06 Polyarthritis, unspecified (Lower leg)
0.000 0.914 0.085
M13.05 Polyarthritis, unspecified (Pelvic region and thigh)
0.000 0.914 0.085
M13.04 Polyarthritis, unspecified (Hand)
0.000 0.914 0.085
M13.03 Polyarthritis, unspecified (Forearm)
0.000 0.914 0.085
M13.02 Polyarthritis, unspecified (Upper arm)
0.000 0.914 0.085
M13.01 Polyarthritis, unspecified (Shoulder region)
0.000 0.914 0.085
E26.0 Primary hyperaldosteronism
0.000 0.914 0.085
E24.9 Cushing's syndrome, unspecified
0.000 0.914 0.085
M13.8 Other specified arthritis
0.000 0.914 0.085
E22.1 Hyperprolactinaemia
0.000 0.917 0.083
E26.9 Hyperaldosteronism, unspecified
0.000 0.919 0.081
E26.8 Other hyperaldosteronism
0.000 0.919 0.081
E26.1 Secondary hyperaldosteronism
0.000 0.919 0.081
E22.0 Acromegaly and pituitary gigantism
0.000 0.920 0.080
M13.16 Monoarthritis, not elsewhere classified (Lower leg)
0.000 0.921 0.079
E24.8 Other Cushing's syndrome
0.000 0.921 0.079
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.000 0.921 0.079
E24.3 Ectopic ACTH syndrome
0.000 0.921 0.079
E24.1 Nelson's syndrome
0.000 0.921 0.079
E24.0 Pituitary-dependent Cushing's disease
0.000 0.921 0.079
E25.9 Adrenogenital disorder, unspecified
0.000 0.923 0.077
E25.8 Other adrenogenital disorders
0.000 0.923 0.077
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.000 0.923 0.077
E30.9 Disorder of puberty, unspecified
0.000 0.923 0.077
E30.8 Other disorders of puberty
0.000 0.923 0.077
E30.1 Precocious puberty
0.000 0.923 0.077
E30.0 Delayed puberty
0.000 0.923 0.077
E31.9 Polyglandular dysfunction, unspecified
0.000 0.923 0.077
E31.8 Other polyglandular dysfunction
0.000 0.923 0.077
E31.1 Polyglandular hyperfunction
0.000 0.923 0.077
E31.0 Autoimmune polyglandular failure
0.000 0.923 0.077
E32.9 Disease of thymus, unspecified
0.000 0.923 0.077
E32.8 Other diseases of thymus
0.000 0.923 0.077
E32.1 Abscess of thymus
0.000 0.923 0.077
E32.0 Persistent hyperplasia of thymus
0.000 0.923 0.077
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.923 0.077
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.923 0.077
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.923 0.077
M13.19 Monoarthritis, not elsewhere classified (Site unspecified)
0.000 0.923 0.077
M13.18 Monoarthritis, not elsewhere classified (Other)
0.000 0.923 0.077
M13.17 Monoarthritis, not elsewhere classified (Ankle and foot)
0.000 0.923 0.077
M13.15 Monoarthritis, not elsewhere classified (Pelvic region and thigh)
0.000 0.923 0.077
M13.14 Monoarthritis, not elsewhere classified (Hand)
0.000 0.923 0.077
M13.13 Monoarthritis, not elsewhere classified (Forearm)
0.000 0.923 0.077
M13.12 Monoarthritis, not elsewhere classified (Upper arm)
0.000 0.923 0.077
M13.11 Monoarthritis, not elsewhere classified (Shoulder region)
0.000 0.923 0.077
M13.10 Monoarthritis, not elsewhere classified (Multiple sites)
0.000 0.923 0.077
E29.9 Testicular dysfunction, unspecified
0.000 0.925 0.075
E29.8 Other testicular dysfunction
0.000 0.925 0.075
E29.0 Testicular hyperfunction
0.000 0.925 0.075
E24.2 Drug-induced Cushing's syndrome
0.000 0.926 0.074
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.927 0.073
E22.8 Other hyperfunction of pituitary gland
0.000 0.927 0.073
E70-E90 Metabolic disorders
0.000 0.927 0.073
E29.1 Testicular hypofunction
0.000 0.927 0.072
E20.8 Other hypoparathyroidism
0.000 0.928 0.072
E20.1 Pseudohypoparathyroidism
0.000 0.928 0.072
E20.0 Idiopathic hypoparathyroidism
0.000 0.928 0.072
E27 Other disorders of adrenal gland
0.000 0.928 0.071
K90-K93 Other diseases of the digestive system
0.000 0.933 0.067
E04.2 Non-toxic multinodular goitre
0.004 0.933 0.063
E20.9 Hypoparathyroidism, unspecified
0.000 0.936 0.064
E23 Hypofunction and other disorders of pituitary gland
0.001 0.936 0.063
E83.1 Disorders of iron metabolism
0.000 0.936 0.064
E83 Disorders of mineral metabolism
0.000 0.937 0.063
E04.9 Non-toxic goitre, unspecified
0.005 0.938 0.056
M13.89 Other specified arthritis (Site unspecified)
0.000 0.938 0.061
M13.88 Other specified arthritis (Other)
0.000 0.938 0.061
M13.87 Other specified arthritis (Ankle and foot)
0.000 0.938 0.061
M13.85 Other specified arthritis (Pelvic region and thigh)
0.000 0.938 0.061
M13.84 Other specified arthritis (Hand)
0.000 0.938 0.061
M13.83 Other specified arthritis (Forearm)
0.000 0.938 0.061
M13.82 Other specified arthritis (Upper arm)
0.000 0.938 0.061
M13.81 Other specified arthritis (Shoulder region)
0.000 0.938 0.061
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.000 0.939 0.060
E85 Amyloidosis
0.000 0.942 0.058
E27.1 Primary adrenocortical insufficiency
0.000 0.944 0.055
E04.1 Non-toxic single thyroid nodule
0.007 0.945 0.049
E28 Ovarian dysfunction
0.001 0.946 0.053
M13.80 Other specified arthritis (Multiple sites)
0.001 0.946 0.053
E84 Cystic fibrosis
0.000 0.947 0.053
E79 Disorders of purine and pyrimidine metabolism
0.000 0.947 0.053
E77 Disorders of glycoprotein metabolism
0.000 0.947 0.053
E76 Disorders of glycosaminoglycan metabolism
0.000 0.947 0.053
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.000 0.947 0.053
E72 Other disorders of amino-acid metabolism
0.000 0.947 0.053
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.000 0.947 0.053
E70 Disorders of aromatic amino-acid metabolism
0.000 0.947 0.053
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.000 0.947 0.053
M13.86 Other specified arthritis (Lower leg)
0.001 0.948 0.052
E74 Other disorders of carbohydrate metabolism
0.000 0.948 0.052
E27.5 Adrenomedullary hyperfunction
0.000 0.948 0.051
E27.3 Drug-induced adrenocortical insufficiency
0.000 0.948 0.051
E27.0 Other adrenocortical overactivity
0.000 0.948 0.051
E23.6 Other disorders of pituitary gland
0.000 0.950 0.050
E80 Disorders of porphyrin and bilirubin metabolism
0.000 0.951 0.049
K93 Disorders of other digestive organs in diseases classified elsewhere
0.000 0.952 0.048
E88 Other metabolic disorders
0.000 0.952 0.048
E85.4 Organ-limited amyloidosis
0.000 0.952 0.047
E27.9 Disorder of adrenal gland, unspecified
0.000 0.953 0.047
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.001 0.954 0.046
E23.1 Drug-induced hypopituitarism
0.001 0.954 0.046
E27.4 Other and unspecified adrenocortical insufficiency
0.000 0.954 0.046
M05-M14 Inflammatory polyarthropathies
0.000 0.954 0.046
E83.9 Disorder of mineral metabolism, unspecified
0.000 0.955 0.045
E83.8 Other disorders of mineral metabolism
0.000 0.955 0.045
E83.2 Disorders of zinc metabolism
0.000 0.955 0.045
E83.0 Disorders of copper metabolism
0.000 0.955 0.045
I84.9 Unspecified haemorrhoids without complication
0.044 0.956 0.000
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.000 0.956 0.044
E27.8 Other specified disorders of adrenal gland
0.000 0.956 0.044
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.000 0.956 0.044
K91 Postprocedural disorders of digestive system, not elsewhere classified
0.000 0.956 0.044
E21.5 Disorder of parathyroid gland, unspecified
0.000 0.956 0.043
E21.4 Other specified disorders of parathyroid gland
0.000 0.956 0.043
E21.2 Other hyperparathyroidism
0.000 0.956 0.043
E23.7 Disorder of pituitary gland, unspecified
0.001 0.957 0.043
E85.9 Amyloidosis, unspecified
0.000 0.958 0.042
E85.8 Other amyloidosis
0.000 0.958 0.042
E85.3 Secondary systemic amyloidosis
0.000 0.958 0.042
E85.2 Heredofamilial amyloidosis, unspecified
0.000 0.958 0.042
E85.1 Neuropathic heredofamilial amyloidosis
0.000 0.958 0.042
E85.0 Nonneuropathic heredofamilial amyloidosis
0.000 0.958 0.042
E83.5 Disorders of calcium metabolism
0.000 0.961 0.039
E28.9 Ovarian dysfunction, unspecified
0.001 0.961 0.038
E28.8 Other ovarian dysfunction
0.001 0.961 0.038
E28.1 Androgen excess
0.001 0.961 0.038
E28.0 Oestrogen excess
0.001 0.961 0.038
E27.2 Addisonian crisis
0.001 0.961 0.038
E70.9 Disorder of aromatic amino-acid metabolism, unspecified
0.000 0.962 0.038
E70.8 Other disorders of aromatic amino-acid metabolism
0.000 0.962 0.038
E70.3 Albinism
0.000 0.962 0.038
E70.2 Disorders of tyrosine metabolism
0.000 0.962 0.038
E70.1 Other hyperphenylalaninaemias
0.000 0.962 0.038
E70.0 Classical phenylketonuria
0.000 0.962 0.038
E71.3 Disorders of fatty-acid metabolism
0.000 0.962 0.038
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified
0.000 0.962 0.038
E71.1 Other disorders of branched-chain amino-acid metabolism
0.000 0.962 0.038
E71.0 Maple-syrup-urine disease
0.000 0.962 0.038
E72.9 Disorder of amino-acid metabolism, unspecified
0.000 0.962 0.038
E72.8 Other specified disorders of amino-acid metabolism
0.000 0.962 0.038
E72.5 Disorders of glycine metabolism
0.000 0.962 0.038
E72.4 Disorders of ornithine metabolism
0.000 0.962 0.038
E72.3 Disorders of lysine and hydroxylysine metabolism
0.000 0.962 0.038
E72.2 Disorders of urea cycle metabolism
0.000 0.962 0.038
E72.1 Disorders of sulphur-bearing amino-acid metabolism
0.000 0.962 0.038
E72.0 Disorders of amino-acid transport
0.000 0.962 0.038
E75.6 Lipid storage disorder, unspecified
0.000 0.962 0.038
E75.5 Other lipid storage disorders
0.000 0.962 0.038
E75.4 Neuronal ceroid lipofuscinosis
0.000 0.962 0.038
E75.3 Sphingolipidosis, unspecified
0.000 0.962 0.038
E75.2 Other sphingolipidosis
0.000 0.962 0.038
E75.1 Other gangliosidosis
0.000 0.962 0.038
E75.0 GM2 gangliosidosis
0.000 0.962 0.038
E76.9 Disorder of glucosaminoglycan metabolism, unspecified
0.000 0.962 0.038
E76.8 Other disorders of glucosaminoglycan metabolism
0.000 0.962 0.038
E76.3 Mucopolysaccharidosis, unspecified
0.000 0.962 0.038
E76.2 Other mucopolysaccharidoses
0.000 0.962 0.038
E76.1 Mucopolysaccharidosis, type II
0.000 0.962 0.038
E76.0 Mucopolysaccharidosis, type I
0.000 0.962 0.038
E77.9 Disorder of glycoprotein metabolism, unspecified
0.000 0.962 0.038
E77.8 Other disorders of glycoprotein metabolism
0.000 0.962 0.038
E77.1 Defects in glycoprotein degradation
0.000 0.962 0.038
E77.0 Defects in posttranslational modification of lysosomal enzymes
0.000 0.962 0.038
E79.9 Disorder of purine and pyrimidine metabolism, unspecified
0.000 0.962 0.038
E79.8 Other disorders of purine and pyrimidine metabolism
0.000 0.962 0.038
E79.1 Lesch-Nyhan syndrome
0.000 0.962 0.038
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
0.000 0.962 0.038
E84.9 Cystic fibrosis, unspecified
0.000 0.962 0.038
E84.8 Cystic fibrosis with other manifestations
0.000 0.962 0.038
E84.1 Cystic fibrosis with intestinal manifestations
0.000 0.962 0.038
E84.0 Cystic fibrosis with pulmonary manifestations
0.000 0.962 0.038
M11 Other crystal arthropathies
0.000 0.962 0.038
K91.8 Other postprocedural disorders of digestive system, not elsewhere classified
0.000 0.962 0.038
E73 Lactose intolerance
0.001 0.963 0.036
E74.9 Disorder of carbohydrate metabolism, unspecified
0.000 0.963 0.037
E74.8 Other specified disorders of carbohydrate metabolism
0.000 0.963 0.037
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
0.000 0.963 0.037
E74.2 Disorders of galactose metabolism
0.000 0.963 0.037
E74.1 Disorders of fructose metabolism
0.000 0.963 0.037
E74.0 Glycogen storage disease
0.000 0.963 0.037
E74.3 Other disorders of intestinal carbohydrate absorption
0.000 0.963 0.036
M07 Psoriatic and enteropathic arthropathies
0.000 0.964 0.035
E80.7 Disorder of bilirubin metabolism, unspecified
0.000 0.964 0.035
E80.6 Other disorders of bilirubin metabolism
0.000 0.964 0.035
E80.5 Crigler-Najjar syndrome
0.000 0.964 0.035
E80.3 Defects of catalase and peroxydase
0.000 0.964 0.035
E80.2 Other porphyria
0.000 0.964 0.035
E80.1 Porphyria cutanea tarda
0.000 0.964 0.035
E80.0 Hereditary erythropoietic porphyria
0.000 0.964 0.035
M14 Arthropathies in other diseases classified elsewhere
0.000 0.965 0.035
K93.8 Disorders of other specified digestive organs in diseases classified elsewhere
0.000 0.965 0.035
K93.1 Megacolon in Chagas' disease
0.000 0.965 0.035
K93.0 Tuberculous disorders of intestines, peritoneum and mesenteric glands
0.000 0.965 0.035
E89.2 Postprocedural hypoparathyroidism
0.000 0.965 0.035
E88.9 Metabolic disorder, unspecified
0.000 0.965 0.034
E88.8 Other specified metabolic disorders
0.000 0.965 0.034
E88.3 Tumour lysis syndrome
0.000 0.965 0.034
E88.1 Lipodystrophy, not elsewhere classified
0.000 0.965 0.034
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.001 0.966 0.034
M10 Gout
0.000 0.966 0.034
M12 Other specific arthropathies
0.000 0.967 0.033
M09 Juvenile arthritis in diseases classified elsewhere
0.000 0.967 0.033
M08 Juvenile arthritis
0.000 0.967 0.033
M11.2 Other chondrocalcinosis
0.000 0.968 0.032
E88.2 Lipomatosis, not elsewhere classified
0.000 0.968 0.032
E88.0 Disorders of plasma-protein metabolism, not elsewhere classified
0.000 0.968 0.032
K91.9 Postprocedural disorder of digestive system, unspecified
0.000 0.968 0.032
E80.4 Gilbert's syndrome
0.000 0.968 0.032
K91.0 Vomiting following gastro-intestinal surgery
0.000 0.968 0.032
E89.9 Postprocedural endocrine and metabolic disorder, unspecified
0.000 0.968 0.032
E89.8 Other postprocedural endocrine and metabolic disorders
0.000 0.968 0.032
E89.5 Postprocedural testicular hypofunction
0.000 0.968 0.032
E89.4 Postprocedural ovarian failure
0.000 0.968 0.032
E89.1 Postprocedural hypoinsulinaemia
0.000 0.968 0.032
K91.2 Postsurgical malabsorption, not elsewhere classified
0.000 0.968 0.032
K91.4 Colostomy and enterostomy malfunction
0.000 0.970 0.030
E89.3 Postprocedural hypopituitarism
0.000 0.970 0.030
E21.0 Primary hyperparathyroidism
0.000 0.970 0.030
E89.6 Postprocedural adrenocortical(-medullary) hypofunction
0.000 0.970 0.030
K91.5 Postcholecystectomy syndrome
0.000 0.971 0.029
E23.0 Hypopituitarism
0.001 0.971 0.029
K91.1 Postgastric surgery syndromes
0.000 0.971 0.029
M11.26 Other chondrocalcinosis (Lower leg)
0.000 0.972 0.028
E23.2 Diabetes insipidus
0.001 0.972 0.027
M07.3 Other psoriatic arthropathies
0.000 0.972 0.028
E11.9 Without complications
0.000 0.972 0.028
M10.9 Gout, unspecified
0.000 0.972 0.028
M14.6 Neuropathic arthropathy
0.000 0.972 0.027
M11.9 Crystal arthropathy, unspecified
0.000 0.972 0.027
M11.8 Other specified crystal arthropathies
0.000 0.972 0.027
M11.1 Familial chondrocalcinosis
0.000 0.972 0.027
M11.0 Hydroxyapatite deposition disease
0.000 0.972 0.027
E73.8 Other lactose intolerance
0.001 0.973 0.026
E73.1 Secondary lactase deficiency
0.001 0.973 0.026
E73.0 Congenital lactase deficiency
0.001 0.973 0.026
E83.4 Disorders of magnesium metabolism
0.000 0.974 0.026
M07.6 Other enteropathic arthropathies
0.000 0.974 0.025
M07.5 Arthropathy in ulcerative colitis
0.000 0.974 0.025
M07.4 Arthropathy in Crohn's disease [regional enteritis]
0.000 0.974 0.025
M07.2 Psoriatic spondylitis
0.000 0.974 0.025
M07.1 Arthritis mutilans
0.000 0.974 0.025
M07.0 Distal interphalangeal psoriatic arthropathy
0.000 0.974 0.025
M05 Seropositive rheumatoid arthritis
0.000 0.974 0.025
M14.8 Arthropathies in other specified diseases classified elsewhere
0.000 0.974 0.025
M14.5 Arthropathies in other endocrine, nutritional and metabolic disorders
0.000 0.974 0.025
M14.4 Arthropathy in amyloidosis
0.000 0.974 0.025
M14.3 Lipoid dermatoarthritis
0.000 0.974 0.025
M14.2 Diabetic arthropathy
0.000 0.974 0.025
M14.1 Crystal arthropathy in other metabolic disorders
0.000 0.974 0.025
M14.0 Gouty arthropathy due to enzyme defects and other inherited disorders
0.000 0.974 0.025
E28.3 Primary ovarian failure
0.002 0.975 0.023
M10.99 Gout, unspecified (Site unspecified)
0.000 0.975 0.025
E83.3 Disorders of phosphorus metabolism
0.000 0.975 0.025
M10.4 Other secondary gout
0.000 0.975 0.025
M10.3 Gout due to impairment of renal function
0.000 0.975 0.025
M10.2 Drug-induced gout
0.000 0.975 0.025
M10.1 Lead-induced gout
0.000 0.975 0.025
E86 Volume depletion
0.000 0.975 0.025
E21.3 Hyperparathyroidism, unspecified
0.000 0.976 0.024

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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