TreeWAS – Variant ID: rs28362677

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	Risk posterior probability	No effect posterior probability	Protective posterior probability
C44.3 Skin of other and unspecified parts of face	1.000	0.000	0.000
E10.9 Without complications	0.000	0.000	1.000
K51.9 Ulcerative colitis, unspecified	1.000	0.000	0.000
K90.0 Coeliac disease	0.000	0.000	1.000
C44 Other malignant neoplasms of skin	1.000	0.000	0.000
K51 Ulcerative colitis	1.000	0.000	0.000
J45.9 Asthma, unspecified	0.000	0.000	1.000
E10 Insulin-dependent diabetes mellitus	0.000	0.000	1.000
C44.7 Skin of lower limb, including hip	0.999	0.001	0.000
K50-K52 Noninfective enteritis and colitis	0.999	0.001	0.000
K50 Crohn's disease [regional enteritis]	0.999	0.001	0.000
K50.1 Crohn's disease of large intestine	0.999	0.001	0.000
C44.4 Skin of scalp and neck	0.996	0.004	0.000
Z93.2 Ileostomy status	0.995	0.005	0.000
C82.9 Follicular non-Hodgkin's lymphoma, unspecified	0.994	0.006	0.000
D86.9 Sarcoidosis, unspecified	0.000	0.006	0.994
D86 Sarcoidosis	0.000	0.007	0.993
K51.4 Pseudopolyposis of colon	0.990	0.010	0.000
E10.1 With ketoacidosis	0.000	0.010	0.990
C82 Follicular [nodular] non-Hodgkin's lymphoma	0.990	0.010	0.000
E10.3 With ophthalmic complications	0.000	0.011	0.989
D86.0 Sarcoidosis of lung	0.000	0.017	0.983
C44.2 Skin of ear and external auricular canal	0.974	0.026	0.000
C44.5 Skin of trunk	0.969	0.031	0.000
C44.6 Skin of upper limb, including shoulder	0.969	0.031	0.000
C81-C96 Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissue	0.966	0.034	0.000
K51.8 Other ulcerative colitis	0.957	0.043	0.000
C44.0 Skin of lip	0.956	0.044	0.000
K51.2 Ulcerative (chronic) proctitis	0.954	0.046	0.000
C83 Diffuse non-Hodgkin's lymphoma	0.949	0.051	0.000
C85 Other and unspecified types of non-Hodgkin's lymphoma	0.946	0.054	0.000
C83.3 Large cell (diffuse)	0.943	0.057	0.000
C85.9 Non-Hodgkin's lymphoma, unspecified type	0.933	0.067	0.000
K50.9 Crohn's disease, unspecified	0.930	0.070	0.000
D86.8 Sarcoidosis of other and combined sites	0.000	0.084	0.916
C82.0 Small cleaved cell, follicular	0.910	0.090	0.000
D86.1 Sarcoidosis of lymph nodes	0.000	0.104	0.896
E10-E14 Diabetes mellitus	0.000	0.104	0.896
D51 Vitamin B12 deficiency anaemia	0.000	0.127	0.873
D50-D53 Nutritional anaemias	0.000	0.129	0.871
D51.0 Vitamin B12 deficiency anaemia due to intrinsic factor deficiency	0.000	0.131	0.869
E16.2 Hypoglycaemia, unspecified	0.000	0.137	0.863
E16 Other disorders of pancreatic internal secretion	0.000	0.139	0.861
D80-D89 Certain disorders involving the immune mechanism	0.000	0.140	0.860
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion	0.000	0.141	0.859
Chapter IV Endocrine, nutritional and metabolic diseases	0.000	0.142	0.858
K52 Other non-infective gastro-enteritis and colitis	0.852	0.148	0.000
D50 Iron deficiency anaemia	0.000	0.150	0.850
D50.9 Iron deficiency anaemia, unspecified	0.000	0.151	0.849
E10.8 With unspecified complications	0.000	0.158	0.842
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	0.000	0.160	0.840
K51.5 Mucosal proctocolitis	0.836	0.164	0.000
C82.7 Other types of follicular non-Hodgkin's lymphoma	0.830	0.170	0.000
E20-E35 Disorders of other endocrine glands	0.000	0.187	0.813
E27 Other disorders of adrenal gland	0.000	0.195	0.805
D51.9 Vitamin B12 deficiency anaemia, unspecified	0.000	0.196	0.804
E27.1 Primary adrenocortical insufficiency	0.000	0.199	0.801
C82.3 Follicular lymphoma grade IIIa	0.797	0.203	0.000
C44.1 Skin of eyelid, including canthus	0.793	0.207	0.000
E10.4 With neurological complications	0.000	0.221	0.779
K90 Intestinal malabsorption	0.000	0.223	0.777
E10.0 With coma	0.000	0.226	0.774
C44.9 Malignant neoplasm of skin, unspecified	0.765	0.235	0.000
K52.1 Toxic gastro-enteritis and colitis	0.754	0.246	0.000
E10.6 With other specified complications	0.000	0.246	0.754
C83.1 Small cleaved cell (diffuse)	0.750	0.250	0.000
K52.8 Other specified non-infective gastro-enteritis and colitis	0.748	0.252	0.000
C85.1 B-cell lymphoma, unspecified	0.746	0.254	0.000
K50.8 Other Crohn's disease	0.741	0.259	0.000
K51.3 Ulcerative (chronic) rectosigmoiditis	0.732	0.268	0.000
C44.8 Overlapping lesion of skin	0.717	0.283	0.000
E10.7 With multiple complications	0.000	0.283	0.717
E22 Hyperfunction of pituitary gland	0.000	0.284	0.716
C81 Hodgkin's disease	0.716	0.284	0.000
C83.9 Diffuse non-Hodgkin's lymphoma, unspecified	0.716	0.284	0.000
E10.2 With renal complications	0.000	0.286	0.714
K52.3 Indeterminate colitis	0.713	0.287	0.000
C82.2 Large cell, follicular	0.713	0.287	0.000
D86.3 Sarcoidosis of skin	0.000	0.288	0.712
D86.2 Sarcoidosis of lung with sarcoidosis of lymph nodes	0.000	0.288	0.712
C82.6 Cutaneous follicle centre lymphoma	0.709	0.290	0.000
C82.5 Diffuse follicle centre lymphoma	0.709	0.290	0.000
C82.4 Follicular lymphoma grade IIIb	0.709	0.290	0.000
K51.0 Ulcerative (chronic) enterocolitis	0.709	0.291	0.000
E16.1 Other hypoglycaemia	0.000	0.305	0.695
K90.4 Malabsorption due to intolerance, not elsewhere classified	0.000	0.305	0.695
C96 Other and unspecified malignant neoplasms of lymphoid, haematopoietic and related tissue	0.693	0.307	0.000
C94 Other leukaemias of specified cell type	0.693	0.307	0.000
C93 Monocytic leukaemia	0.693	0.307	0.000
C86 Other specified types of T/NK-cell lymphoma	0.693	0.307	0.000
C84 Peripheral and cutaneous T-cell lymphomas	0.689	0.311	0.000
D52 Folate deficiency anaemia	0.000	0.317	0.683
C95 Leukaemia of unspecified cell type	0.683	0.317	0.000
C83.6 Undifferentiated (diffuse)	0.681	0.319	0.000
C83.5 Lymphoblastic (diffuse)	0.681	0.319	0.000
C83.4 Immunoblastic (diffuse)	0.681	0.319	0.000
C83.2 Mixed small and large cell (diffuse)	0.681	0.319	0.000
C85.2 Mediastinal (thymic) large B-cell lymphoma	0.678	0.321	0.000
C85.0 Lymphosarcoma	0.678	0.321	0.000
C82.1 Mixed small cleaved and large cell, follicular	0.668	0.332	0.000
E13 Other specified diabetes mellitus	0.000	0.332	0.668
E14 Unspecified diabetes mellitus	0.000	0.333	0.667
E16.0 Drug-induced hypoglycaemia without coma	0.000	0.335	0.665
E21 Hyperparathyroidism and other disorders of parathyroid gland	0.000	0.345	0.655
C83.7 Burkitt's tumour	0.653	0.346	0.000
E10.5 With peripheral circulatory complications	0.000	0.355	0.645
E12 Malnutrition-related diabetes mellitus	0.000	0.357	0.643
K51.1 Ulcerative (chronic) ileocolitis	0.640	0.360	0.000
E27.4 Other and unspecified adrenocortical insufficiency	0.000	0.364	0.636
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone	0.000	0.365	0.635
E24 Cushing's syndrome	0.000	0.366	0.634
E27.2 Addisonian crisis	0.000	0.366	0.634
D51.8 Other vitamin B12 deficiency anaemias	0.000	0.374	0.626
D51.3 Other dietary vitamin B12 deficiency anaemia	0.000	0.374	0.626
D51.2 Transcobalamin II deficiency	0.000	0.374	0.626
D51.1 Vitamin B12 deficiency anaemia due to selective vitamin B12 malabsorption with proteinuria	0.000	0.374	0.626
K90.9 Intestinal malabsorption, unspecified	0.000	0.376	0.624
C90 Multiple myeloma and malignant plasma cell neoplasms	0.622	0.377	0.000
K52.2 Allergic and dietetic gastro-enteritis and colitis	0.622	0.378	0.000
C88 Malignant immunoproliferative diseases	0.620	0.379	0.000
E16.9 Disorder of pancreatic internal secretion, unspecified	0.000	0.382	0.618
E16.8 Other specified disorders of pancreatic internal secretion	0.000	0.382	0.618
E16.4 Abnormal secretion of gastrin	0.000	0.382	0.618
E16.3 Increased secretion of glucagon	0.000	0.382	0.618
D82 Immunodeficiency associated with other major defects	0.000	0.383	0.617
D81 Combined immunodeficiencies	0.000	0.383	0.617
E15 Nondiabetic hypoglycaemic coma	0.000	0.384	0.616
D50.1 Sideropenic dysphagia	0.000	0.390	0.610
D53 Other nutritional anaemias	0.000	0.396	0.604
C83.8 Other types of diffuse non-Hodgkin's lymphoma	0.597	0.403	0.000
E20 Hypoparathyroidism	0.000	0.412	0.588
K90.8 Other intestinal malabsorption	0.000	0.412	0.588
C81.1 Nodular sclerosis	0.584	0.416	0.000
E35 Disorders of endocrine glands in diseases classified elsewhere	0.000	0.417	0.583
E32 Diseases of thymus	0.000	0.417	0.583
E31 Polyglandular dysfunction	0.000	0.417	0.583
E30 Disorders of puberty, not elsewhere classified	0.000	0.417	0.583
E25 Adrenogenital disorders	0.000	0.417	0.583
E27.3 Drug-induced adrenocortical insufficiency	0.000	0.422	0.578
E27.5 Adrenomedullary hyperfunction	0.000	0.423	0.577
E27.0 Other adrenocortical overactivity	0.000	0.423	0.577
C85.7 Other specified types of non-Hodgkin's lymphoma	0.572	0.428	0.000
D55-D59 Haemolytic anaemias	0.000	0.438	0.562
K90.3 Pancreatic steatorrhoea	0.000	0.443	0.557
K90.2 Blind loop syndrome, not elsewhere classified	0.000	0.443	0.557
K90.1 Tropical sprue	0.000	0.443	0.557
E40-E46 Malnutrition	0.000	0.445	0.554
D52.9 Folate deficiency anaemia, unspecified	0.000	0.452	0.548
C81.2 Mixed cellularity	0.545	0.455	0.000
E14.9 Without complications	0.000	0.455	0.545
C43-C44 Melanoma and other malignant neoplasms of skin	0.543	0.457	0.000
E21.0 Primary hyperparathyroidism	0.000	0.457	0.543
C81.0 Lymphocytic predominance	0.540	0.460	0.000
D83 Common variable immunodeficiency	0.000	0.460	0.540
E34 Other endocrine disorders	0.000	0.464	0.536
E27.8 Other specified disorders of adrenal gland	0.000	0.465	0.535
E22.0 Acromegaly and pituitary gigantism	0.000	0.467	0.533
C95.0 Acute leukaemia of unspecified cell type	0.530	0.469	0.000
D80 Immunodeficiency with predominantly antibody defects	0.000	0.470	0.530
E22.1 Hyperprolactinaemia	0.000	0.473	0.527
E22.9 Hyperfunction of pituitary gland, unspecified	0.000	0.486	0.514
E22.8 Other hyperfunction of pituitary gland	0.000	0.486	0.514
C81.7 Other Hodgkin's disease	0.513	0.487	0.000
C81.4 Lymphocyte-rich classical Hodgkin lymphoma	0.513	0.487	0.000
C81.3 Lymphocytic depletion	0.513	0.487	0.000
E65-E68 Obesity and other hyperalimentation	0.000	0.487	0.513
C84.0 Mycosis fungoides	0.507	0.493	0.000
E24.9 Cushing's syndrome, unspecified	0.000	0.494	0.505
E13.9 Without complications	0.000	0.496	0.504
E21.1 Secondary hyperparathyroidism, not elsewhere classified	0.000	0.496	0.504
E14.3 With ophthalmic complications	0.000	0.499	0.501
D84 Other immunodeficiencies	0.001	0.501	0.499
C84.4 Peripheral T-cell lymphoma	0.497	0.503	0.000
C86.6 Primary cutaneous CD30-positive T-cell proliferations	0.497	0.503	0.000
C86.5 Angioimmunoblastic T-cell lymphoma	0.497	0.503	0.000
C86.4 Blastic NK-cell lymphoma	0.497	0.503	0.000
C86.3 Subcutaneous panniculitis-like T-cell lymphoma	0.497	0.503	0.000
C86.2 Enteropathy-type (intestinal) T-cell lymphoma	0.497	0.503	0.000
C86.1 Hepatosplenic T-cell lymphoma	0.497	0.503	0.000
C86.0 Extranodal NK/T-cell lymphoma, nasal type	0.497	0.503	0.000
C93.9 Monocytic leukaemia, unspecified	0.497	0.503	0.000
C93.7 Other monocytic leukaemia	0.497	0.503	0.000
C93.3 Juvenile myelomonocytic leukaemia	0.497	0.503	0.000
C93.2 Subacute monocytic leukaemia	0.497	0.503	0.000
C93.1 Chronic monocytic leukaemia	0.497	0.503	0.000
C93.0 Acute monocytic leukaemia	0.497	0.503	0.000
C94.7 Other specified leukaemias	0.497	0.503	0.000
C94.6 Myelodysplastic and myeloproliferative disease, not elsewhere classified	0.497	0.503	0.000
C94.5 Acute myelofibrosis	0.497	0.503	0.000
C94.4 Acute panmyelosis	0.497	0.503	0.000
C94.3 Mast cell leukaemia	0.497	0.503	0.000
C94.2 Acute megakaryoblastic leukaemia	0.497	0.503	0.000
C94.1 Chronic erythraemia	0.497	0.503	0.000
C94.0 Acute erythraemia and erythroleukaemia	0.497	0.503	0.000
C96.9 Malignant neoplasms of lymphoid, haematopoietic and related tissue, unspecified	0.497	0.503	0.000
C96.8 Histiocytic sarcoma	0.497	0.503	0.000
C96.7 Other specified malignant neoplasms of lymphoid, haematopoietic and related tissue	0.497	0.503	0.000
C96.6 Unifocal Langerhans-cell histiocytosis	0.497	0.503	0.000
C96.5 Multifocal and unisystemic Langerhans-cell histiocytosis	0.497	0.503	0.000
C96.4 Sarcoma of dendritic cells (accessory cells)	0.497	0.503	0.000
C96.3 True histiocytic lymphoma	0.497	0.503	0.000
C96.2 Malignant mast cell tumour	0.497	0.503	0.000
C96.1 Malignant histiocytosis	0.497	0.503	0.000
C96.0 Letterer-Siwe disease	0.497	0.503	0.000
C84.9 Mature T/NK-cell lymphoma, unspecified	0.494	0.506	0.000
C84.8 Cutaneous T-cell lymphoma, unspecified	0.494	0.506	0.000
C84.7 Anaplastic large cell lymphoma, ALK-negative	0.494	0.506	0.000
C84.6 Anaplastic large cell lymphoma, ALK-positive	0.494	0.506	0.000
C84.3 Lymphoepithelioid lymphoma	0.494	0.506	0.000
C84.2 T-zone lymphoma	0.494	0.506	0.000
C84.1 Sezary's diease	0.494	0.506	0.000
D52.8 Other folate deficiency anaemias	0.000	0.510	0.490
D52.1 Drug-induced folate deficiency anaemia	0.000	0.510	0.490
D52.0 Dietary folate deficiency anaemia	0.000	0.510	0.490
C95.7 Other leukaemia of unspecified cell type	0.489	0.510	0.000
C95.2 Subacute leukaemia of unspecified cell type	0.489	0.510	0.000
C95.1 Chronic leukaemia of unspecified cell type	0.489	0.510	0.000
E29 Testicular dysfunction	0.000	0.511	0.489
E13.8 With unspecified complications	0.000	0.521	0.479
E13.7 With multiple complications	0.000	0.521	0.479
E13.6 With other specified complications	0.000	0.521	0.479
E13.5 With peripheral circulatory complications	0.000	0.521	0.479
E13.4 With neurological complications	0.000	0.521	0.479
E13.3 With ophthalmic complications	0.000	0.521	0.479
E13.2 With renal complications	0.000	0.521	0.479
E13.1 With ketoacidosis	0.000	0.521	0.479
E13.0 With coma	0.000	0.521	0.479
E14.8 With unspecified complications	0.000	0.522	0.478
E14.7 With multiple complications	0.000	0.522	0.478
E14.2 Withrenal complications	0.000	0.522	0.478
E14.1 With ketoacidosis	0.000	0.522	0.478
E14.0 With coma	0.000	0.522	0.478
C84.5 Other and unspecified T-cell lymphomas	0.472	0.528	0.000
E21.5 Disorder of parathyroid gland, unspecified	0.000	0.530	0.470
E21.4 Other specified disorders of parathyroid gland	0.000	0.530	0.470
E21.2 Other hyperparathyroidism	0.000	0.530	0.470
K52.0 Gastro-enteritis and colitis due to radiation	0.464	0.536	0.000
E14.6 With other specified complications	0.000	0.537	0.463
D59 Acquired haemolytic anaemia	0.000	0.537	0.463
E50-E64 Other nutritional deficiencies	0.000	0.538	0.462
E12.9 Without complications	0.000	0.539	0.461
E12.8 With unspecified complications	0.000	0.539	0.461
E12.7 With multiple complications	0.000	0.539	0.461
E12.6 With other specified complications	0.000	0.539	0.461
E12.5 With peripheral circulatory complications	0.000	0.539	0.461
E12.4 With neurological complications	0.000	0.539	0.461
E12.3 With ophthalmic complications	0.000	0.539	0.461
E12.2 With renal complications	0.000	0.539	0.461
E12.1 With ketoacidosis	0.000	0.539	0.461
E12.0 With coma	0.000	0.539	0.461
E14.5 With peripheral circulatory complications	0.000	0.542	0.458
E24.8 Other Cushing's syndrome	0.000	0.545	0.454
E24.4 Alcohol-induced pseudo-Cushing's syndrome	0.000	0.545	0.454
E24.3 Ectopic ACTH syndrome	0.000	0.545	0.454
E24.2 Drug-induced Cushing's syndrome	0.000	0.545	0.454
E24.1 Nelson's syndrome	0.000	0.545	0.454
E24.0 Pituitary-dependent Cushing's disease	0.000	0.545	0.454
E34.0 Carcinoid syndrome	0.000	0.553	0.447
C90.3 Solitary plasmacytoma	0.446	0.553	0.000
C90.1 Plasma cell leukaemia	0.446	0.553	0.000
C91 Lymphoid leukaemia	0.444	0.554	0.001
C88.9 Malignant immunoproliferative disease, unspecified	0.445	0.555	0.000
C88.7 Other malignant immunoproliferative diseases	0.445	0.555	0.000
C88.4 Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue [MALT-lymphoma]	0.445	0.555	0.000
C88.3 Immunoproliferative small intestinal disease	0.445	0.555	0.000
C88.2 Gamma heavy chain disease	0.445	0.555	0.000
C88.1 Alpha heavy chain disease	0.445	0.555	0.000
D81.9 Combined immunodeficiency, unspecified	0.000	0.558	0.442
D81.8 Other combined immunodeficiencies	0.000	0.558	0.442
D81.7 Major histocompatibility complex class II deficiency	0.000	0.558	0.442
D81.6 Major histocompatibility complex class I deficiency	0.000	0.558	0.442
D81.5 Purine nucleoside phosphorylase [PNP] deficiency	0.000	0.558	0.442
D81.4 Nezelof's syndrome	0.000	0.558	0.442
D81.3 Adenosine deaminase [ADA] deficiency	0.000	0.558	0.442
D81.2 Severe combined immunodeficiency [SCID] with low or normal B-cell numbers	0.000	0.558	0.442
D81.1 Severe combined immunodeficiency [SCID] with low T- and B-cell numbers	0.000	0.558	0.442
D81.0 Severe combined immunodeficiency [SCID] with reticular dysgenesis	0.000	0.558	0.442
D82.9 Immunodeficiency associated with major defect, unspecified	0.000	0.558	0.442
D82.8 Immunodeficiency associated with other specified major defects	0.000	0.558	0.442
D82.4 Hyperimmunoglobulin E [IgE] syndrome	0.000	0.558	0.442
D82.3 Immunodeficiency following hereditary defective response to Epstein-Barr virus	0.000	0.558	0.442
D82.2 Immunodeficiency with short-limbed stature	0.000	0.558	0.442
D82.1 Di George's syndrome	0.000	0.558	0.442
D82.0 Wiskott-Aldrich syndrome	0.000	0.558	0.442
C90.0 Multiple myeloma	0.440	0.560	0.000
D53.8 Other specified nutritional anaemias	0.000	0.567	0.433
D53.2 Scorbutic anaemia	0.000	0.567	0.433
D53.1 Other megaloblastic anaemias, not elsewhere classified	0.000	0.567	0.433
D53.0 Protein deficiency anaemia	0.000	0.567	0.433
E00-E07 Disorders of thyroid gland	0.000	0.567	0.433
D89 Other disorders involving the immune mechanism, not elsewhere classified	0.000	0.568	0.431
D50.0 Iron deficiency anaemia secondary to blood loss (chronic)	0.000	0.570	0.430
C83.0 Small cell (diffuse)	0.429	0.571	0.001
E14.4 With neurological complications	0.000	0.573	0.427
E20.9 Hypoparathyroidism, unspecified	0.000	0.573	0.426
E21.3 Hyperparathyroidism, unspecified	0.000	0.575	0.425
C95.9 Leukaemia, unspecified	0.425	0.575	0.000
E20.8 Other hypoparathyroidism	0.000	0.578	0.421
E20.1 Pseudohypoparathyroidism	0.000	0.578	0.421
E20.0 Idiopathic hypoparathyroidism	0.000	0.578	0.421
E25.9 Adrenogenital disorder, unspecified	0.000	0.582	0.418
E25.8 Other adrenogenital disorders	0.000	0.582	0.418
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency	0.000	0.582	0.418
E30.9 Disorder of puberty, unspecified	0.000	0.582	0.418
E30.8 Other disorders of puberty	0.000	0.582	0.418
E30.1 Precocious puberty	0.000	0.582	0.418
E30.0 Delayed puberty	0.000	0.582	0.418
E31.9 Polyglandular dysfunction, unspecified	0.000	0.582	0.418
E31.8 Other polyglandular dysfunction	0.000	0.582	0.418
E31.1 Polyglandular hyperfunction	0.000	0.582	0.418
E31.0 Autoimmune polyglandular failure	0.000	0.582	0.418
E32.9 Disease of thymus, unspecified	0.000	0.582	0.418
E32.8 Other diseases of thymus	0.000	0.582	0.418
E32.1 Abscess of thymus	0.000	0.582	0.418
E32.0 Persistent hyperplasia of thymus	0.000	0.582	0.418
E35.8 Disorders of other endocrine glands in diseases classified elsewhere	0.000	0.582	0.418
E35.1 Disorders of adrenal glands in diseases classified elsewhere	0.000	0.582	0.418
E35.0 Disorders of thyroid gland in diseases classified elsewhere	0.000	0.582	0.418
D53.9 Nutritional anaemia, unspecified	0.000	0.588	0.412
D57 Sickle-cell disorders	0.000	0.597	0.403
D55 Anaemia due to enzyme disorders	0.000	0.597	0.403
C92 Myeloid leukaemia	0.399	0.600	0.000
E44 Protein-energy malnutrition of moderate and mild degree	0.000	0.602	0.398
E45 Retarded development following protein-energy malnutrition	0.000	0.602	0.398
E43 Unspecified severe protein-energy malnutrition	0.000	0.602	0.398
E42 Marasmic kwashiorkor	0.000	0.602	0.398
E41 Nutritional marasmus	0.000	0.602	0.398
E40 Kwashiorkor	0.000	0.602	0.398
D59.1 Other autoimmune haemolytic anaemias	0.000	0.607	0.393
E53 Deficiency of other B group vitamins	0.000	0.612	0.388
D83.8 Other common variable immunodeficiencies	0.000	0.613	0.387
D83.2 Common variable immunodeficiency with autoantibodies to B- or T-cells	0.000	0.613	0.387
D83.1 Common variable immunodeficiency with predominant immunoregulatory T-cell disorders	0.000	0.613	0.387
D83.0 Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function	0.000	0.613	0.387
C90.2 Plasmacytoma, extramedullary	0.385	0.615	0.000
E34.5 Androgen resistance syndrome	0.000	0.615	0.384
E34.4 Constitutional tall stature	0.000	0.615	0.384
E34.3 Short stature, not elsewhere classified	0.000	0.615	0.384
E34.2 Ectopic hormone secretion, not elsewhere classified	0.000	0.615	0.384
E34.1 Other hypersecretion of intestinal hormones	0.000	0.615	0.384
E03 Other hypothyroidism	0.000	0.618	0.382
C91.5 Adult T-cell leukaemia	0.380	0.619	0.001
D80.9 Immunodeficiency with predominantly antibody defects, unspecified	0.000	0.620	0.380
D80.8 Other immunodeficiencies with predominantly antibody defects	0.000	0.620	0.380
D80.7 Transient hypogammaglobulinaemia of infancy	0.000	0.620	0.380
D80.6 Antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinaemia	0.000	0.620	0.380
D80.5 Immunodeficiency with increased immunoglobulin M [IgM]	0.000	0.620	0.380
D80.4 Selective deficiency of immunoglobulin M [IgM]	0.000	0.620	0.380
D80.3 Selective deficiency of immunoglobulin G [IgG] subclasses	0.000	0.620	0.380
D80.0 Hereditary hypogammaglobulinaemia	0.000	0.620	0.380
E28 Ovarian dysfunction	0.000	0.624	0.375
E66 Obesity	0.000	0.626	0.374
C88.0 Waldenstrom's macroglobulinaemia	0.372	0.627	0.000
E67 Other hyperalimentation	0.000	0.632	0.368
E68 Sequelae of hyperalimentation	0.000	0.632	0.368
J45 Asthma	0.000	0.632	0.368
D84.8 Other specified immunodeficiencies	0.001	0.642	0.358
D84.1 Defects in the complement system	0.001	0.642	0.358
D84.0 Lymphocyte function antigen-1 [LFA-1] defect	0.001	0.642	0.358
C91.9 Lymphoid leukaemia, unspecified	0.356	0.644	0.001
Chapter II Neoplasms	0.354	0.646	0.000
D80.1 Nonfamilial hypogammaglobulinaemia	0.000	0.647	0.353
C73-C75 Malignant neoplasms of thyroid and other endocrine glands	0.351	0.649	0.000
E29.9 Testicular dysfunction, unspecified	0.000	0.649	0.350
E29.8 Other testicular dysfunction	0.000	0.649	0.350
E29.0 Testicular hyperfunction	0.000	0.649	0.350
C73 Malignant neoplasm of thyroid gland	0.349	0.651	0.000
E03.9 Hypothyroidism, unspecified	0.000	0.652	0.348
E26 Hyperaldosteronism	0.002	0.654	0.344
E05 Thyrotoxicosis [hyperthyroidism]	0.000	0.655	0.345
D56 Thalassaemia	0.000	0.655	0.344
E34.8 Other specified endocrine disorders	0.000	0.658	0.342
E27.9 Disorder of adrenal gland, unspecified	0.001	0.659	0.341
C81.9 Hodgkin's disease, unspecified	0.339	0.660	0.000
E53.8 Deficiency of other specified B group vitamins	0.000	0.662	0.338
E46 Unspecified protein-energy malnutrition	0.000	0.663	0.337
M06.9 Rheumatoid arthritis, unspecified	0.335	0.665	0.000
D59.8 Other acquired haemolytic anaemias	0.000	0.668	0.332
D59.6 Haemoglobinuria due to haemolysis from other external causes	0.000	0.668	0.332
D59.5 Paroxysmal nocturnal haemoglobinuria [Marchiafava-Micheli]	0.000	0.668	0.332
D59.4 Other nonautoimmune haemolytic anaemias	0.000	0.668	0.332
D59.3 Haemolytic-uraemic syndrome	0.000	0.668	0.332
D59.2 Drug-induced nonautoimmune haemolytic anaemia	0.000	0.668	0.332
D59.0 Drug-induced autoimmune haemolytic anaemia	0.000	0.668	0.332
E64 Sequelae of malnutrition and other nutritional deficiencies	0.000	0.668	0.331
E63 Other nutritional deficiencies	0.000	0.668	0.331
E56 Other vitamin deficiencies	0.000	0.668	0.331
E50 Vitamin A deficiency	0.000	0.668	0.331
E60 Dietary zinc deficiency	0.000	0.668	0.331
E59 Dietary selenium deficiency	0.000	0.668	0.331
E54 Ascorbic acid deficiency	0.000	0.668	0.331
E52 Niacin deficiency [pellagra]	0.000	0.668	0.331
D80.2 Selective deficiency of immunoglobulin A [IgA]	0.000	0.670	0.329
D59.9 Acquired haemolytic anaemia, unspecified	0.000	0.671	0.329
M06 Other rheumatoid arthritis	0.328	0.672	0.000
D58 Other hereditary haemolytic anaemias	0.000	0.672	0.328
M06.0 Seronegative rheumatoid arthritis	0.327	0.673	0.000
E05.0 Thyrotoxicosis with diffuse goitre	0.000	0.674	0.326
M06.00 Seronegative rheumatoid arthritis (Multiple sites)	0.323	0.677	0.000
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)	0.322	0.678	0.000
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)	0.320	0.680	0.000
C91.8 Mature B-cell leukaemia Burkitt-type	0.319	0.680	0.001
C91.7 Other lymphoid leukaemia	0.319	0.680	0.001
C91.6 Prolymphocytic leukaemia of T-cell type	0.319	0.680	0.001
C91.3 Prolymphocytic leukaemia	0.319	0.680	0.001
C91.2 Subacute lymphocytic leukaemia	0.319	0.680	0.001
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions	0.000	0.684	0.316
E01 Iodine-deficiency-related thyroid disorders and allied conditions	0.000	0.689	0.310
E00 Congenital iodine-deficiency syndrome	0.000	0.689	0.310
D83.9 Common variable immunodeficiency, unspecified	0.001	0.690	0.310
D89.9 Disorder involving the immune mechanism, unspecified	0.000	0.690	0.309
D89.8 Other specified disorders involving the immune mechanism, not elsewhere classified	0.000	0.690	0.309
D89.3 Immune reconstitution syndrome	0.000	0.690	0.309
D89.0 Polyclonal hypergammaglobulinaemia	0.000	0.690	0.309
E51 Thiamine deficiency	0.000	0.693	0.307
E58 Dietary calcium deficiency	0.000	0.694	0.305
M06.96 Rheumatoid arthritis, unspecified (Lower leg)	0.300	0.700	0.000
E06 Thyroiditis	0.000	0.709	0.291
E11 Non-insulin-dependent diabetes mellitus	0.000	0.709	0.291
D55.9 Anaemia due to enzyme disorder, unspecified	0.000	0.711	0.289
D55.8 Other anaemias due to enzyme disorders	0.000	0.711	0.289
D55.3 Anaemia due to disorders of nucleotide metabolism	0.000	0.711	0.289
D55.2 Anaemia due to disorders of glycolytic enzymes	0.000	0.711	0.289
D55.1 Anaemia due to other disorders of glutathione metabolism	0.000	0.711	0.289
D55.0 Anaemia due to glucose-6-phosphate dehydrogenase [G6PD] deficiency	0.000	0.711	0.289
D57.8 Other sickle-cell disorders	0.000	0.711	0.289
D57.3 Sickle-cell trait	0.000	0.711	0.289
D57.2 Double heterozygous sickling disorders	0.000	0.711	0.289
D57.1 Sickle-cell anaemia without crisis	0.000	0.711	0.289
D57.0 Sickle-cell anaemia with crisis	0.000	0.711	0.289
E66.8 Other obesity	0.000	0.711	0.289
C00-C14 Malignant neoplasms of lip, oral cavity and pharynx	0.288	0.712	0.000
C92.9 Myeloid leukaemia, unspecified	0.286	0.713	0.000
C92.8 Acute myeloid leukaemia with multilineage dysplasia	0.286	0.713	0.000
C92.7 Other myeloid leukaemia	0.286	0.713	0.000
C92.6 Acute myeloid leukaemia with 11q23-abnormality	0.286	0.713	0.000
C92.5 Acute myelomonocytic leukaemia	0.286	0.713	0.000
C92.4 Acute promyelocytic leukaemia	0.286	0.713	0.000
C92.3 Myeloid sarcoma	0.286	0.713	0.000
C92.2 Subacute myeloid leukaemia	0.286	0.713	0.000
E44.1 Mild protein-energy malnutrition	0.000	0.715	0.285
E44.0 Moderate protein-energy malnutrition	0.000	0.715	0.285
E03.2 Hypothyroidism due to medicaments and other exogenous substances	0.000	0.718	0.282
E66.2 Extreme obesity with alveolar hypoventilation	0.000	0.720	0.280
E53.1 Pyridoxine deficiency	0.000	0.721	0.279
E53.0 Riboflavin deficiency	0.000	0.721	0.279
M06.98 Rheumatoid arthritis, unspecified (Other)	0.278	0.721	0.000
M06.09 Seronegative rheumatoid arthritis (Site unspecified)	0.277	0.723	0.000
C43 Malignant melanoma of skin	0.276	0.724	0.000
E53.9 Vitamin B deficiency, unspecified	0.000	0.725	0.274
C74 Malignant neoplasm of adrenal gland	0.274	0.726	0.000
E03.5 Myxoedema coma	0.000	0.726	0.274
E03.4 Atrophy of thyroid (acquired)	0.000	0.726	0.274
E03.3 Postinfectious hypothyroidism	0.000	0.726	0.274
E03.1 Congenital hypothyroidism without goitre	0.000	0.726	0.274
E03.0 Congenital hypothyroidism with diffuse goitre	0.000	0.726	0.274
E34.9 Endocrine disorder, unspecified	0.001	0.727	0.272
D89.1 Cryoglobulinaemia	0.000	0.730	0.270
E28.9 Ovarian dysfunction, unspecified	0.000	0.730	0.269
E28.8 Other ovarian dysfunction	0.000	0.730	0.269
E28.1 Androgen excess	0.000	0.730	0.269
E28.0 Oestrogen excess	0.000	0.730	0.269
E66.9 Obesity, unspecified	0.000	0.731	0.269
E02 Subclinical iodine-deficiency hypothyroidism	0.000	0.731	0.269
E66.1 Drug-induced obesity	0.000	0.732	0.268
M45.X9 Ankylosing spondylitis (Site unspecified)	0.267	0.733	0.000
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)	0.265	0.735	0.000
E67.8 Other specified hyperalimentation	0.000	0.736	0.264
E67.3 Hypervitaminosis D	0.000	0.736	0.264
E67.2 Megavitamin-B6 syndrome	0.000	0.736	0.264
E67.1 Hypercarotenaemia	0.000	0.736	0.264
E67.0 Hypervitaminosis A	0.000	0.736	0.264
J45.8 Mixed asthma	0.000	0.736	0.264
J45.1 Nonallergic asthma	0.000	0.736	0.264
E61 Deficiency of other nutrient elements	0.000	0.736	0.263
C02 Malignant neoplasm of other and unspecified parts of tongue	0.263	0.737	0.000
M06.97 Rheumatoid arthritis, unspecified (Ankle and foot)	0.261	0.739	0.000
E11.1 With ketoacidosis	0.000	0.741	0.259
K50.0 Crohn's disease of small intestine	0.257	0.742	0.001
D50.8 Other iron deficiency anaemias	0.000	0.743	0.257
E23 Hypofunction and other disorders of pituitary gland	0.001	0.743	0.256
E03.8 Other specified hypothyroidism	0.000	0.743	0.257
E29.1 Testicular hypofunction	0.000	0.744	0.256
C91.0 Acute lymphoblastic leukaemia	0.255	0.744	0.001
E65 Localised adiposity	0.000	0.745	0.255
D70-D77 Other diseases of blood and blood-forming organs	0.000	0.747	0.253
C75 Malignant neoplasm of other endocrine glands and related structures	0.252	0.748	0.000
C40-C41 Malignant neoplasms of bone and articular cartilage	0.249	0.751	0.000
E05.8 Other thyrotoxicosis	0.000	0.752	0.248
E26.8 Other hyperaldosteronism	0.001	0.752	0.247
E26.1 Secondary hyperaldosteronism	0.001	0.752	0.247
E05.5 Thyroid crisis or storm	0.000	0.752	0.248
E05.4 Thyrotoxicosis factitia	0.000	0.752	0.248
E05.3 Thyrotoxicosis from ectopic thyroid tissue	0.000	0.752	0.248
E05.1 Thyrotoxicosis with toxic single thyroid nodule	0.000	0.752	0.248
D56.9 Thalassaemia, unspecified	0.000	0.753	0.247
D56.8 Other thalassaemias	0.000	0.753	0.247
D56.4 Hereditary persistence of foetal haemoglobin [HPFH]	0.000	0.753	0.247
D56.2 Delta-beta thalassaemia	0.000	0.753	0.247
D56.0 Alpha thalassaemia	0.000	0.753	0.247

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations