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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs28366266
log Bayes Factor = 92.0158
Chromosome 6   position 32,559,753  (GRCh37) Explore rs28366266 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)
0.000 0.000 1.000
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)
0.000 0.000 1.000
E03.9 Hypothyroidism, unspecified
0.000 0.000 1.000
E05.9 Thyrotoxicosis, unspecified
0.000 0.000 1.000
E10.9 Without complications
0.000 0.000 1.000
E10.3 With ophthalmic complications
0.000 0.000 1.000
L40.9 Psoriasis, unspecified
1.000 0.000 0.000
M06.9 Rheumatoid arthritis, unspecified
0.000 0.000 1.000
M35.3 Polymyalgia rheumatica
0.000 0.000 1.000
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
M06 Other rheumatoid arthritis
0.000 0.000 1.000
M35 Other systemic involvement of connective tissue
0.000 0.000 1.000
E00-E07 Disorders of thyroid gland
0.000 0.000 1.000
M05-M14 Inflammatory polyarthropathies
0.000 0.000 1.000
Chapter X Diseases of the respiratory system
0.000 0.000 1.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.000 1.000
# Top node
0.000 0.000 1.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue
0.000 0.000 1.000
Chapter VII Diseases of the eye and adnexa
0.000 0.000 1.000
H36.0 Diabetic retinopathy
0.000 0.000 1.000
L40 Psoriasis
1.000 0.000 0.000
E03 Other hypothyroidism
0.000 0.000 1.000
M20-M25 Other joint disorders
0.000 0.000 1.000
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.000 1.000
M05.9 Seropositive rheumatoid arthritis, unspecified
0.000 0.000 1.000
L40.5 Arthropathic psoriasis
1.000 0.000 0.000
M05 Seropositive rheumatoid arthritis
0.000 0.000 1.000
E10-E14 Diabetes mellitus
0.000 0.000 1.000
M05.90 Seropositive rheumatoid arthritis, unspecified (Multiple sites)
0.000 0.000 1.000
H00-H06 Disorders of eyelid, lacrimal system and orbit
0.000 0.000 1.000
M35.0 Sicca syndrome [Sjogren]
0.000 0.001 0.999
H36 Retinal disorders in diseases classified elsewhere
0.000 0.001 0.999
H30-H36 Disorders of choroid and retina
0.000 0.001 0.999
E10.1 With ketoacidosis
0.000 0.001 0.999
J80-J84 Other respiratory diseases principally affecting the interstitium
0.000 0.001 0.999
J47 Bronchiectasis
0.000 0.002 0.998
Chapter XII Diseases of the skin and subcutaneous tissue
0.000 0.002 0.998
J40-J47 Chronic lower respiratory diseases
0.000 0.003 0.997
G35 Multiple sclerosis
0.000 0.003 0.997
M06.94 Rheumatoid arthritis, unspecified (Hand)
0.000 0.005 0.995
M06.97 Rheumatoid arthritis, unspecified (Ankle and foot)
0.000 0.011 0.989
L55-L59 Radiation-related disorders of the skin and subcutaneous tissue
0.000 0.011 0.989
J20-J22 Other acute lower respiratory infections
0.000 0.012 0.988
L80-L99 Other disorders of the skin and subcutaneous tissue
0.000 0.012 0.988
M34 Systemic sclerosis
0.000 0.014 0.986
H02 Other disorders of eyelid
0.000 0.014 0.986
L57 Skin changes due to chronic exposure to nonionising radiation
0.000 0.017 0.983
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.000 0.019 0.981
J22 Unspecified acute lower respiratory infection
0.000 0.025 0.975
J84 Other interstitial pulmonary diseases
0.000 0.029 0.971
H02.0 Entropion and trichiasis of eyelid
0.000 0.030 0.970
H02.1 Ectropion of eyelid
0.000 0.032 0.968
J80 Adult respiratory distress syndrome
0.000 0.034 0.966
J95-J99 Other diseases of the respiratory system
0.000 0.039 0.961
M06.96 Rheumatoid arthritis, unspecified (Lower leg)
0.000 0.039 0.961
L57.8 Other skin changes due to chronic exposure to nonionising radiation
0.000 0.040 0.960
H06 Disorders of lachrymal system and orbit in diseases classified elsewhere
0.000 0.042 0.958
E10.4 With neurological complications
0.000 0.043 0.957
D50-D53 Nutritional anaemias
0.000 0.044 0.956
H04 Disorders of lachrymal system
0.000 0.044 0.956
M05.99 Seropositive rheumatoid arthritis, unspecified (Site unspecified)
0.000 0.045 0.955
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions
0.000 0.049 0.951
E06 Thyroiditis
0.000 0.052 0.948
M34.9 Systemic sclerosis, unspecified
0.000 0.055 0.945
H55-H59 Other disorders of eye and adnexa
0.000 0.056 0.944
L40.0 Psoriasis vulgaris
0.943 0.057 0.000
E20-E35 Disorders of other endocrine glands
0.000 0.058 0.941
M06.0 Seronegative rheumatoid arthritis
0.000 0.063 0.937
H06.2 Dysthyroid exophthalmos
0.000 0.072 0.928
L57.0 Actinic keratosis
0.000 0.073 0.927
M06.91 Rheumatoid arthritis, unspecified (Shoulder region)
0.000 0.076 0.924
E10.2 With renal complications
0.000 0.080 0.920
L81 Other disorders of pigmentation
0.000 0.080 0.920
L20-L30 Dermatitis and eczema
0.000 0.082 0.918
D68 Other coagulation defects
0.000 0.082 0.918
D50 Iron deficiency anaemia
0.000 0.083 0.917
E10.5 With peripheral circulatory complications
0.000 0.084 0.916
E27 Other disorders of adrenal gland
0.000 0.084 0.916
G35-G37 Demyelinating diseases of the central nervous system
0.000 0.086 0.914
H57 Other disorders of eye and adnexa
0.000 0.092 0.908
D50.8 Other iron deficiency anaemias
0.000 0.092 0.908
J95 Postprocedural respiratory disorders, not elsewhere classified
0.000 0.092 0.908
E06.3 Autoimmune thyroiditis
0.000 0.100 0.900
M35.1 Other overlap syndromes
0.000 0.101 0.899
L98 Other disorders of skin and subcutaneous tissue, not elsewhere classified
0.000 0.103 0.897
J84.9 Interstitial pulmonary disease, unspecified
0.000 0.103 0.897
E27.1 Primary adrenocortical insufficiency
0.000 0.104 0.896
L97 Ulcer of lower limb, not elsewhere classified
0.000 0.104 0.896
L81.4 Other melanin hyperpigmentation
0.000 0.113 0.887
N48 Other disorders of penis
0.885 0.115 0.000
L82 Seborrhoeic keratosis
0.000 0.116 0.884
M34.1 CR(E)ST syndrome
0.000 0.118 0.882
N48.6 Balanitis xerotica obliterans
0.881 0.119 0.000
H04.5 Stenosis and insufficiency of lachrymal passages
0.000 0.121 0.879
J81 Pulmonary oedema
0.000 0.122 0.878
L83 Acanthosis nigricans
0.000 0.131 0.869
M06.3 Rheumatoid nodule
0.000 0.134 0.866
J84.1 Other interstitial pulmonary diseases with fibrosis
0.000 0.134 0.866
E04 Other non-toxic goitre
0.000 0.136 0.864
E07 Other disorders of thyroid
0.000 0.139 0.861
H57.0 Anomalies of pupillary function
0.000 0.142 0.858
M06.09 Seronegative rheumatoid arthritis (Site unspecified)
0.000 0.146 0.854
N48.8 Other specified disorders of penis
0.850 0.150 0.000
D52 Folate deficiency anaemia
0.000 0.153 0.847
D69 Purpura and other haemorrhagic conditions
0.000 0.154 0.846
Chapter VI Diseases of the nervous system
0.000 0.160 0.840
M06.93 Rheumatoid arthritis, unspecified (Forearm)
0.000 0.160 0.840
J95.8 Other postprocedural respiratory disorders
0.000 0.160 0.840
M06.4 Inflammatory polyarthropathy
0.000 0.164 0.836
M06.92 Rheumatoid arthritis, unspecified (Upper arm)
0.000 0.169 0.831
E04.2 Non-toxic multinodular goitre
0.000 0.176 0.824
H04.3 Acute and unspecified inflammation of lachrymal passages
0.000 0.177 0.823
D68.5 Primary Thrombophilia
0.000 0.178 0.822
L98.8 Other specified disorders of skin and subcutaneous tissue
0.000 0.178 0.822
L94 Other localised connective tissue disorders
0.000 0.182 0.818
N48.0 Leukoplakia of penis
0.814 0.186 0.000
M60-M63 Disorders of muscles
0.000 0.188 0.812
H05 Disorders of orbit
0.000 0.189 0.811
L29 Pruritus
0.000 0.189 0.811
M34.8 Other forms of systemic sclerosis
0.000 0.193 0.807
J99 Respiratory disorders in diseases classified elsewhere
0.000 0.193 0.807
J95.0 Tracheostomy malfunction
0.000 0.196 0.804
L93 Lupus erythematosus
0.000 0.199 0.801
D68.8 Other specified coagulation defects
0.000 0.200 0.800
M32 Systemic lupus erythematosus
0.000 0.201 0.799
D60-D64 Aplastic and other anaemias
0.000 0.201 0.799
H04.1 Other disorders of lachrymal gland
0.000 0.201 0.799
H04.8 Other disorders of lachrymal system
0.000 0.206 0.794
J82 Pulmonary eosinophilia, not elsewhere classified
0.000 0.206 0.794
M06.00 Seronegative rheumatoid arthritis (Multiple sites)
0.000 0.206 0.794
N48.9 Disorder of penis, unspecified
0.793 0.207 0.000
J44 Other chronic obstructive pulmonary disease
0.000 0.207 0.793
E28 Ovarian dysfunction
0.000 0.207 0.793
H01 Other inflammation of eyelid
0.000 0.209 0.791
L40-L45 Papulosquamous disorders
0.466 0.211 0.324
L98.4 Chronic ulcer of skin, not elsewhere classified
0.000 0.211 0.789
E20 Hypoparathyroidism
0.000 0.212 0.788
E23 Hypofunction and other disorders of pituitary gland
0.000 0.212 0.788
D68.9 Coagulation defect, unspecified
0.000 0.213 0.787
J84.8 Other specified interstitial pulmonary diseases
0.000 0.216 0.784
J20 Acute bronchitis
0.000 0.217 0.783
M06.34 Rheumatoid nodule (Hand)
0.000 0.220 0.780
L95 Vasculitis limited to skin, not elsewhere classified
0.000 0.220 0.780
N48.4 Impotence of organic origin
0.774 0.226 0.000
D52.9 Folate deficiency anaemia, unspecified
0.000 0.232 0.768
L40.1 Generalised pustular psoriasis
0.766 0.234 0.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.234 0.766
M35.7 Hypermobility syndrome
0.000 0.235 0.765
L30 Other dermatitis
0.000 0.236 0.764
D61 Other aplastic anaemias
0.000 0.242 0.758
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.000 0.242 0.757
L29.0 Pruritus ani
0.000 0.247 0.753
D68.0 Von Willebrand's disease
0.000 0.248 0.752
L56 Other acute skin changes due to ultraviolet radiation
0.000 0.250 0.750
E07.9 Disorder of thyroid, unspecified
0.000 0.250 0.750
J21 Acute bronchiolitis
0.000 0.252 0.748
H57.9 Disorder of eye and adnexa, unspecified
0.000 0.255 0.745
E29 Testicular dysfunction
0.000 0.256 0.743
E06.9 Thyroiditis, unspecified
0.000 0.258 0.742
D69.5 Secondary thrombocytopenia
0.000 0.260 0.740
H33 Retinal detachments and breaks
0.000 0.261 0.739
J44.8 Other specified chronic obstructive pulmonary disease
0.000 0.265 0.735
H02.6 Xanthelasma of eyelid
0.000 0.266 0.734
M30 Polyarteritis nodosa and related conditions
0.000 0.266 0.734
D65 Disseminated intravascular coagulation [defibrination syndrome]
0.000 0.267 0.733
L21 Seborrhoeic dermatitis
0.000 0.267 0.733
M05.97 Seropositive rheumatoid arthritis, unspecified (Ankle and foot)
0.000 0.269 0.731
L84 Corns and callosities
0.000 0.269 0.731
M06.40 Inflammatory polyarthropathy (Multiple sites)
0.000 0.272 0.728
L57.4 Cutis laxa senilis
0.000 0.273 0.727
H57.8 Other specified disorders of eye and adnexa
0.000 0.273 0.727
D61.9 Aplastic anaemia, unspecified
0.000 0.273 0.727
H55 Nystagmus and other irregular eye movements
0.000 0.275 0.725
L80 Vitiligo
0.000 0.275 0.725
J99.1 Respiratory disorders in other diffuse connective tissue disorders
0.000 0.276 0.724
N48.1 Balanoposthitis
0.723 0.277 0.000
H02.2 Lagophthalmos
0.000 0.282 0.718
E05.8 Other thyrotoxicosis
0.000 0.283 0.717
E05.5 Thyroid crisis or storm
0.000 0.283 0.717
E05.4 Thyrotoxicosis factitia
0.000 0.283 0.717
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.283 0.717
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.283 0.717
E10.7 With multiple complications
0.000 0.283 0.717
E10.0 With coma
0.000 0.283 0.717
M06.8 Other specified rheumatoid arthritis
0.000 0.283 0.717
M06.2 Rheumatoid bursitis
0.000 0.283 0.717
M06.1 Adult-onset Still's disease
0.000 0.283 0.717
M35.9 Systemic involvement of connective tissue, unspecified
0.000 0.283 0.717
M35.8 Other specified systemic involvement of connective tissue
0.000 0.283 0.717
M35.6 Relapsing panniculitis [Weber-Christian]
0.000 0.283 0.717
M35.5 Multifocal fibrosclerosis
0.000 0.283 0.717
M35.4 Diffuse (eosinophilic) fasciitis
0.000 0.283 0.717
M35.2 Behcet's disease
0.000 0.283 0.717
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.283 0.717
E00 Congenital iodine-deficiency syndrome
0.000 0.283 0.717
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.283 0.717
M09 Juvenile arthritis in diseases classified elsewhere
0.000 0.283 0.717
M08 Juvenile arthritis
0.000 0.283 0.717
Chapter XVI Certain conditions originating in the perinatal period
0.000 0.283 0.717
L40.4 Guttate psoriasis
0.717 0.283 0.000
L40.3 Pustulosis palmaris et plantaris
0.717 0.283 0.000
L40.2 Acrodermatitis continua
0.717 0.283 0.000
M36 Systemic disorders of connective tissue in diseases classified elsewhere
0.000 0.283 0.717
E03.5 Myxoedema coma
0.000 0.283 0.717
E03.4 Atrophy of thyroid (acquired)
0.000 0.283 0.717
E03.3 Postinfectious hypothyroidism
0.000 0.283 0.717
E03.1 Congenital hypothyroidism without goitre
0.000 0.283 0.717
M05.98 Seropositive rheumatoid arthritis, unspecified (Other)
0.000 0.283 0.717
M05.96 Seropositive rheumatoid arthritis, unspecified (Lower leg)
0.000 0.283 0.717
M05.95 Seropositive rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.000 0.283 0.717
M05.94 Seropositive rheumatoid arthritis, unspecified (Hand)
0.000 0.283 0.717
M05.93 Seropositive rheumatoid arthritis, unspecified (Forearm)
0.000 0.283 0.717
M05.92 Seropositive rheumatoid arthritis, unspecified (Upper arm)
0.000 0.283 0.717
M05.91 Seropositive rheumatoid arthritis, unspecified (Shoulder region)
0.000 0.283 0.717
M05.8 Other seropositive rheumatoid arthritis
0.000 0.283 0.717
M05.3 Rheumatoid arthritis with involvement of other organs and systems
0.000 0.283 0.717
M05.2 Rheumatoid vasculitis
0.000 0.283 0.717
M05.1 Rheumatoid lung disease
0.000 0.283 0.717
M05.0 Felty's syndrome
0.000 0.283 0.717
E12 Malnutrition-related diabetes mellitus
0.000 0.283 0.717
M22 Disorders of patella
0.000 0.283 0.717
E03.8 Other specified hypothyroidism
0.000 0.283 0.717
H36.8 Other retinal disorders in diseases classified elsewhere
0.000 0.283 0.716
H32 Chorioretinal disorders in diseases classified elsewhere
0.000 0.284 0.716
E10.8 With unspecified complications
0.000 0.284 0.716
J41 Simple and mucopurulent chronic bronchitis
0.000 0.285 0.715
H05.0 Acute inflammation of orbit
0.000 0.288 0.712
J98 Other respiratory disorders
0.000 0.289 0.711
L58 Radiodermatitis
0.000 0.291 0.709
L55 Sunburn
0.000 0.291 0.709
L99 Other disorders of skin and subcutaneous tissue in diseases classified elsewhere
0.000 0.292 0.708
L87 Transepidermal elimination disorders
0.000 0.292 0.708
L88 Pyoderma gangrenosum
0.000 0.292 0.708
L86 Keratoderma in diseases classified elsewhere
0.000 0.292 0.708
M34.2 Systemic sclerosis induced by drugs and chemicals
0.000 0.293 0.707
M34.0 Progressive systemic sclerosis
0.000 0.293 0.707
E14 Unspecified diabetes mellitus
0.000 0.293 0.707
H02.7 Other degenerative disorders of eyelid and periocular area
0.000 0.293 0.707
G37 Other demyelinating diseases of central nervous system
0.000 0.295 0.705
L57.9 Skin changes due to chronic exposure to nonionising radiation, unspecified
0.000 0.295 0.705
L57.5 Actinic granuloma
0.000 0.295 0.705
L57.3 Poikiloderma of Civatte
0.000 0.295 0.705
L57.2 Cutis rhomboidalis nuchae
0.000 0.295 0.705
L57.1 Actinic reticuloid
0.000 0.295 0.705
H02.8 Other specified disorders of eyelid
0.000 0.295 0.705
H30 Chorioretinal inflammation
0.000 0.296 0.704
E27.8 Other specified disorders of adrenal gland
0.000 0.296 0.704
L25 Unspecified contact dermatitis
0.000 0.298 0.702
E50-E64 Other nutritional deficiencies
0.000 0.299 0.701
E04.0 Non-toxic diffuse goitre
0.000 0.300 0.700
N48.5 Ulcer of penis
0.699 0.301 0.000
J84.0 Alveolar and parietoalveolar conditions
0.000 0.303 0.696
H03 Disorders of eyelid in diseases classified elsewhere
0.000 0.304 0.696
H40-H42 Glaucoma
0.000 0.304 0.696
H33.2 Serous retinal detachment
0.000 0.305 0.695
N40-N51 Diseases of male genital organs
0.694 0.306 0.000
H02.5 Other disorders affecting eyelid function
0.000 0.306 0.694
L93.0 Discoid lupus erythematosus
0.000 0.306 0.694
M12 Other specific arthropathies
0.000 0.308 0.692
D69.3 Idiopathic thrombocytopenic purpura
0.000 0.309 0.691
J96 Respiratory failure, not elsewhere classified
0.000 0.311 0.689
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.311 0.688
H58 Other disorders of eye and adnexa in diseases classified elsewhere
0.000 0.312 0.688
D69.0 Allergic purpura
0.000 0.312 0.688
N47 Redundant prepuce, phimosis and paraphimosis
0.688 0.312 0.000
H06.3 Other disorders of orbit in diseases classified elsewhere
0.000 0.313 0.687
H06.1 Parasitic infestation of orbit in diseases classified elsewhere
0.000 0.313 0.687
H06.0 Disorders of lachrymal system in diseases classified elsewhere
0.000 0.313 0.687
M86-M90 Other osteopathies
0.000 0.314 0.686
H04.6 Other changes in lachrymal passages
0.000 0.315 0.685
H04.0 Dacryoadenitis
0.000 0.315 0.685
H04.9 Disorder of lachrymal system, unspecified
0.000 0.316 0.684
E10.6 With other specified complications
0.000 0.317 0.683
D53 Other nutritional anaemias
0.000 0.318 0.682
D67 Hereditary factor IX deficiency
0.000 0.318 0.682
E06.5 Other chronic thyroiditis
0.000 0.320 0.680
E06.4 Drug-induced thyroiditis
0.000 0.320 0.680
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.320 0.680
E06.1 Subacute thyroiditis
0.000 0.320 0.680
E06.0 Acute thyroiditis
0.000 0.320 0.680
E20.9 Hypoparathyroidism, unspecified
0.000 0.322 0.678
E27.9 Disorder of adrenal gland, unspecified
0.000 0.323 0.677
D68.6 Other Thrombophilia
0.000 0.324 0.676
J60-J70 Lung diseases due to external agents
0.000 0.325 0.675
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.325 0.675
E32 Diseases of thymus
0.000 0.325 0.675
E31 Polyglandular dysfunction
0.000 0.325 0.675
E30 Disorders of puberty, not elsewhere classified
0.000 0.325 0.675
M06.98 Rheumatoid arthritis, unspecified (Other)
0.000 0.325 0.675
M62 Other disorders of muscle
0.000 0.326 0.674
M06.08 Seronegative rheumatoid arthritis (Other)
0.000 0.328 0.672
M06.07 Seronegative rheumatoid arthritis (Ankle and foot)
0.000 0.328 0.672
M06.06 Seronegative rheumatoid arthritis (Lower leg)
0.000 0.328 0.672
M06.05 Seronegative rheumatoid arthritis (Pelvic region and thigh)
0.000 0.328 0.672
M06.04 Seronegative rheumatoid arthritis (Hand)
0.000 0.328 0.672
M06.03 Seronegative rheumatoid arthritis (Forearm)
0.000 0.328 0.672
M06.02 Seronegative rheumatoid arthritis (Upper arm)
0.000 0.328 0.672
M06.01 Seronegative rheumatoid arthritis (Shoulder region)
0.000 0.328 0.672
M00-M03 Infectious arthropathies
0.000 0.329 0.671
L30.8 Other specified dermatitis
0.000 0.332 0.668
H01.8 Other specified inflammation of eyelid
0.000 0.333 0.667
L27 Dermatitis due to substances taken internally
0.000 0.335 0.665
D68.1 Hereditary factor XI deficiency
0.000 0.335 0.664
L40.8 Other psoriasis
0.664 0.335 0.000
E26 Hyperaldosteronism
0.000 0.337 0.663
H04.4 Chronic inflammation of lachrymal passages
0.000 0.337 0.662
L81.8 Other specified disorders of pigmentation
0.000 0.338 0.661
M20 Acquired deformities of fingers and toes
0.000 0.339 0.661
L85 Other epidermal thickening
0.000 0.340 0.660
L81.7 Pigmented purpuric dermatosis
0.000 0.340 0.660
L81.6 Other disorders of diminished melanin formation
0.000 0.340 0.660
L81.5 Leukoderma, not elsewhere classified
0.000 0.340 0.660
L81.3 Cafe au lait spots
0.000 0.340 0.660
L81.2 Freckles
0.000 0.340 0.660
L81.1 Chloasma
0.000 0.340 0.660
L81.0 Postinflammatory hyperpigmentation
0.000 0.340 0.660
L24 Irritant contact dermatitis
0.000 0.341 0.658
L26 Exfoliative dermatitis
0.000 0.341 0.658
L22 Diaper [napkin] dermatitis
0.000 0.341 0.658
D68.4 Acquired coagulation factor deficiency
0.000 0.342 0.658
D50.1 Sideropenic dysphagia
0.000 0.342 0.658
J98.1 Pulmonary collapse
0.000 0.342 0.658
L98.9 Disorder of skin and subcutaneous tissue, unspecified
0.000 0.343 0.657
E27.5 Adrenomedullary hyperfunction
0.000 0.343 0.657
E27.0 Other adrenocortical overactivity
0.000 0.343 0.657
D51 Vitamin B12 deficiency anaemia
0.000 0.345 0.655
G36 Other acute disseminated demyelination
0.000 0.345 0.655
M32.1 Systemic lupus erythematosus with organ or system involvement
0.000 0.345 0.655
L94.2 Calcinosis cutis
0.000 0.345 0.655
M24 Other specific joint derangements
0.000 0.346 0.654
J40 Bronchitis, not specified as acute or chronic
0.000 0.346 0.654
E28.2 Polycystic ovarian syndrome
0.000 0.348 0.652
J95.5 Postprocedural subglottic stenosis
0.000 0.349 0.651
J95.4 Mendelson's syndrome
0.000 0.349 0.651
J95.3 Chronic pulmonary insufficiency following surgery
0.000 0.349 0.651
J95.2 Acute pulmonary insufficiency following nonthoracic surgery
0.000 0.349 0.651
J95.1 Acute pulmonary insufficiency following thoracic surgery
0.000 0.349 0.651
E27.4 Other and unspecified adrenocortical insufficiency
0.000 0.349 0.650
M22.2 Patellofemoral disorders
0.000 0.349 0.651
L94.0 Localised scleroderma [morphea]
0.000 0.351 0.649
L10-L14 Bullous disorders
0.000 0.352 0.648
H15-H22 Disorders of sclera, cornea, iris and ciliary body
0.000 0.353 0.647
H05.2 Exophthalmic conditions
0.000 0.353 0.647
L29.2 Pruritus vulvae
0.000 0.353 0.647
E07.8 Other specified disorders of thyroid
0.000 0.355 0.644
E14.3 With ophthalmic complications
0.000 0.356 0.644
L28 Lichen simplex chronicus and prurigo
0.000 0.356 0.643
L98.7 Excessive and redundant skin and subcutaneous tissue
0.000 0.357 0.643
L98.6 Other infiltrative disorders of skin and subcutaneous tissue
0.000 0.357 0.643
L98.3 Eosinophilic cellulitis [Wells]
0.000 0.357 0.643
L98.1 Factitial dermatitis
0.000 0.357 0.643
E27.2 Addisonian crisis
0.000 0.357 0.643
J20.9 Acute bronchitis, unspecified
0.000 0.359 0.641
D69.6 Thrombocytopenia, unspecified
0.000 0.363 0.637
E23.0 Hypopituitarism
0.000 0.363 0.637
L20 Atopic dermatitis
0.000 0.363 0.636
N48.3 Priapism
0.635 0.365 0.000
H35 Other retinal disorders
0.000 0.366 0.634
M91-M94 Chondropathies
0.000 0.367 0.633
E23.2 Diabetes insipidus
0.000 0.368 0.632
E34 Other endocrine disorders
0.000 0.369 0.631
M20.6 Acquired deformity of toe(s), unspecified
0.000 0.372 0.628
L59 Other disorders of skin and subcutaneous tissue related to radiation
0.000 0.372 0.628
L95.8 Other vasculitis limited to skin
0.000 0.376 0.624
D68.3 Haemorrhagic disorder due to circulating anticoagulants
0.000 0.378 0.622
E28.3 Primary ovarian failure
0.000 0.378 0.622
M06.32 Rheumatoid nodule (Upper arm)
0.000 0.378 0.622
M06.39 Rheumatoid nodule (Site unspecified)
0.000 0.379 0.621
M06.38 Rheumatoid nodule (Other)
0.000 0.379 0.621
M06.36 Rheumatoid nodule (Lower leg)
0.000 0.379 0.621
M06.35 Rheumatoid nodule (Pelvic region and thigh)
0.000 0.379 0.621
M06.33 Rheumatoid nodule (Forearm)
0.000 0.379 0.621
M06.31 Rheumatoid nodule (Shoulder region)
0.000 0.379 0.621
M06.30 Rheumatoid nodule (Multiple sites)
0.000 0.379 0.621
E04.8 Other specified non-toxic goitre
0.000 0.380 0.619
M33 Dermatopolymyositis
0.000 0.382 0.618
E07.1 Dyshormogenetic goitre
0.000 0.382 0.618
E07.0 Hypersecretion of calcitonin
0.000 0.382 0.618
M31 Other necrotising vasculopathies
0.000 0.383 0.617
E27.3 Drug-induced adrenocortical insufficiency
0.000 0.383 0.616
H35.4 Peripheral retinal degeneration
0.000 0.385 0.615
H57.1 Ocular pain
0.000 0.387 0.613
E65-E68 Obesity and other hyperalimentation
0.000 0.387 0.613
D52.8 Other folate deficiency anaemias
0.000 0.393 0.607
D52.1 Drug-induced folate deficiency anaemia
0.000 0.393 0.607
D52.0 Dietary folate deficiency anaemia
0.000 0.393 0.607
D69.8 Other specified haemorrhagic conditions
0.000 0.393 0.607
D69.4 Other primary thrombocytopenia
0.000 0.393 0.607
D69.1 Qualitative platelet defects
0.000 0.393 0.607
J44.0 Chronic obstructive pulmonary disease with acute lower respiratory infection
0.000 0.394 0.606
H33.4 Traction detachment of retina
0.000 0.395 0.605
M62.8 Other specified disorders of muscle
0.000 0.395 0.605
J98.9 Respiratory disorder, unspecified
0.000 0.395 0.605
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.395 0.604
M11 Other crystal arthropathies
0.000 0.397 0.603
M14 Arthropathies in other diseases classified elsewhere
0.000 0.398 0.602
E29.1 Testicular hypofunction
0.000 0.398 0.602
L21.9 Seborrhoeic dermatitis, unspecified
0.000 0.400 0.600
M06.48 Inflammatory polyarthropathy (Other)
0.000 0.401 0.599
M06.47 Inflammatory polyarthropathy (Ankle and foot)
0.000 0.401 0.599
M06.46 Inflammatory polyarthropathy (Lower leg)
0.000 0.401 0.599
M06.45 Inflammatory polyarthropathy (Pelvic region and thigh)
0.000 0.401 0.599
M06.44 Inflammatory polyarthropathy (Hand)
0.000 0.401 0.599
M06.43 Inflammatory polyarthropathy (Forearm)
0.000 0.401 0.599
M06.42 Inflammatory polyarthropathy (Upper arm)
0.000 0.401 0.599
M06.41 Inflammatory polyarthropathy (Shoulder region)
0.000 0.401 0.599
E16 Other disorders of pancreatic internal secretion
0.000 0.401 0.598
M45-M49 Spondylopathies
0.000 0.402 0.598
M20.3 Other deformity of hallux (acquired)
0.000 0.403 0.597
L98.5 Mucinosis of skin
0.000 0.404 0.596
L56.8 Other specified acute skin changes due to ultraviolet radiation
0.000 0.407 0.593
M06.37 Rheumatoid nodule (Ankle and foot)
0.000 0.407 0.593
M21 Other acquired deformities of limbs
0.000 0.407 0.593
J99.0 Rheumatoid lung disease
0.000 0.407 0.593
H05.8 Other disorders of orbit
0.000 0.408 0.592
J44.1 Chronic obstructive pulmonary disease with acute exacerbation, unspecified
0.000 0.408 0.592
L98.0 Pyogenic granuloma
0.000 0.409 0.591
J98.0 Diseases of bronchus, not elsewhere classified
0.000 0.411 0.589
M60 Myositis
0.000 0.412 0.588
M45 Ankylosing spondylitis
0.000 0.413 0.587
L94.8 Other specified localised connective tissue disorders
0.000 0.413 0.586
L94.6 Ainhum
0.000 0.413 0.586
L94.5 Poikiloderma vasculare atrophicans
0.000 0.413 0.586
L94.4 Gottron's papules
0.000 0.413 0.586
L94.3 Sclerodactyly
0.000 0.413 0.586
L94.1 Linear scleroderma
0.000 0.413 0.586
M65-M68 Disorders of synovium and tendon
0.000 0.415 0.585
H16 Keratitis
0.000 0.415 0.585
L94.9 Localised connective tissue disorder, unspecified
0.000 0.417 0.583
M63 Disorders of muscle in diseases classified elsewhere
0.000 0.418 0.582
M61 Calcification and ossification of muscle
0.000 0.418 0.582
H05.5 Retained (old) foreign body following penetrating wound of orbit
0.000 0.418 0.582
H05.3 Deformity of orbit
0.000 0.418 0.582
L29.1 Pruritus scroti
0.000 0.418 0.582
E40-E46 Malnutrition
0.000 0.418 0.581
E22 Hyperfunction of pituitary gland
0.000 0.419 0.581
E23.7 Disorder of pituitary gland, unspecified
0.000 0.420 0.579
M06.49 Inflammatory polyarthropathy (Site unspecified)
0.000 0.422 0.578
J21.9 Acute bronchiolitis, unspecified
0.000 0.423 0.576
L93.1 Subacute cutaneous lupus erythematosus
0.000 0.426 0.574
H01.0 Blepharitis
0.000 0.426 0.574
H53-H54 Visual disturbances and blindness
0.000 0.426 0.574
M45.X9 Ankylosing spondylitis (Site unspecified)
0.000 0.427 0.573
M32.9 Systemic lupus erythematosus, unspecified
0.000 0.427 0.573
M32.8 Other forms of systemic lupus erythematosus
0.000 0.427 0.573
M32.0 Drug-induced systemic lupus erythematosus
0.000 0.427 0.573
D60 Acquired pure red cell aplasia [erythroblastopenia]
0.000 0.427 0.573
H59 Postprocedural disorders of eye and adnexa, not elsewhere classified
0.000 0.430 0.570
E61 Deficiency of other nutrient elements
0.000 0.430 0.570
L23 Allergic contact dermatitis
0.000 0.430 0.569
J67 Hypersensitivity pneumonitis due to organic dust
0.000 0.431 0.569
L95.9 Vasculitis limited to skin, unspecified
0.000 0.431 0.569
L30.9 Dermatitis, unspecified
0.000 0.431 0.569
E28.9 Ovarian dysfunction, unspecified
0.000 0.432 0.568
E28.8 Other ovarian dysfunction
0.000 0.432 0.568
E28.1 Androgen excess
0.000 0.432 0.568
E28.0 Oestrogen excess
0.000 0.432 0.568
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.432 0.567
M95-M99 Other disorders of the musculoskeletal system and connective tissue
0.000 0.433 0.567
L44 Other papulosquamous disorders
0.334 0.434 0.232
L41 Parapsoriasis
0.334 0.434 0.232
L45 Papulosquamous disorders in diseases classified elsewhere
0.334 0.434 0.232
M24.8 Other specific joint derangements, not elsewhere classified
0.000 0.435 0.565
E20.8 Other hypoparathyroidism
0.000 0.435 0.565
E20.1 Pseudohypoparathyroidism
0.000 0.435 0.565
E20.0 Idiopathic hypoparathyroidism
0.000 0.435 0.565
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.000 0.435 0.565
E23.1 Drug-induced hypopituitarism
0.000 0.435 0.565
L29.9 Pruritus, unspecified
0.000 0.437 0.563
D50.0 Iron deficiency anaemia secondary to blood loss (chronic)
0.000 0.437 0.563
N41 Inflammatory diseases of prostate
0.562 0.438 0.000
J20.7 Acute bronchitis due to echovirus
0.000 0.438 0.562
J20.6 Acute bronchitis due to rhinovirus
0.000 0.438 0.562
J20.5 Acute bronchitis due to respiratory syncytial virus
0.000 0.438 0.562
J20.4 Acute bronchitis due to parainfluenza virus
0.000 0.438 0.562
J20.3 Acute bronchitis due to coxsackie virus
0.000 0.438 0.562
J20.2 Acute bronchitis due to streptococcus
0.000 0.438 0.562
J20.1 Acute bronchitis due to Haemophilus influenzae
0.000 0.438 0.562
J20.0 Acute bronchitis due to Mycoplasma pneumoniae
0.000 0.438 0.562
M86 Osteomyelitis
0.000 0.439 0.560
L95.1 Erythema elevatum diutinum
0.000 0.441 0.559
L95.0 Livedoid vasculitis
0.000 0.441 0.559
E25 Adrenogenital disorders
0.000 0.441 0.558
J00-J06 Acute upper respiratory infections
0.000 0.443 0.557
N45 Orchitis and epididymitis
0.557 0.443 0.000
D51.9 Vitamin B12 deficiency anaemia, unspecified
0.000 0.445 0.555
D61.1 Drug-induced aplastic anaemia
0.000 0.445 0.555
J20.8 Acute bronchitis due to other specified organisms
0.000 0.446 0.554
M30.0 Polyarteritis nodosa
0.000 0.447 0.553
H05.4 Enophthalmos
0.000 0.448 0.552
H35.8 Other specified retinal disorders
0.000 0.448 0.552
J95.9 Postprocedural respiratory disorder, unspecified
0.000 0.448 0.552
D62 Acute posthaemorrhagic anaemia
0.000 0.448 0.552
M21.0 Valgus deformity, not elsewhere classified
0.000 0.449 0.551
E15 Nondiabetic hypoglycaemic coma
0.000 0.451 0.549
N44 Torsion of testis
0.549 0.451 0.000
N48.2 Other inflammatory disorders of penis
0.549 0.451 0.000
M89 Other disorders of bone
0.000 0.451 0.549
J42 Unspecified chronic bronchitis
0.000 0.452 0.548

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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