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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs28383438
log Bayes Factor = 87.6743
Chromosome 6   position 32,609,038  (GRCh37) Explore rs28383438 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)
0.000 0.000 1.000
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)
0.000 0.000 1.000
E03.9 Hypothyroidism, unspecified
0.000 0.000 1.000
E10.9 Without complications
0.000 0.000 1.000
L40.9 Psoriasis, unspecified
1.000 0.000 0.000
M06.9 Rheumatoid arthritis, unspecified
0.000 0.000 1.000
M35.3 Polymyalgia rheumatica
0.000 0.000 1.000
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
M06 Other rheumatoid arthritis
0.000 0.000 1.000
M35 Other systemic involvement of connective tissue
0.000 0.000 1.000
E00-E07 Disorders of thyroid gland
0.000 0.000 1.000
M05-M14 Inflammatory polyarthropathies
0.000 0.000 1.000
Chapter X Diseases of the respiratory system
0.000 0.000 1.000
Chapter VII Diseases of the eye and adnexa
0.000 0.000 1.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.000 1.000
# Top node
0.000 0.000 1.000
E10.3 With ophthalmic complications
0.000 0.000 1.000
J33 Nasal polyp
0.000 0.000 1.000
L40 Psoriasis
1.000 0.000 0.000
E05.9 Thyrotoxicosis, unspecified
0.000 0.000 1.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue
0.000 0.000 1.000
L40.5 Arthropathic psoriasis
1.000 0.000 0.000
E03 Other hypothyroidism
0.000 0.000 1.000
H00-H06 Disorders of eyelid, lacrimal system and orbit
0.000 0.000 1.000
Chapter XII Diseases of the skin and subcutaneous tissue
0.000 0.000 1.000
J33.0 Polyp of nasal cavity
0.000 0.000 1.000
J30-J39 Other diseases of upper respiratory tract
0.000 0.000 1.000
M05 Seropositive rheumatoid arthritis
0.000 0.000 1.000
J47 Bronchiectasis
0.000 0.000 1.000
M20-M25 Other joint disorders
0.000 0.001 0.999
H36.0 Diabetic retinopathy
0.000 0.001 0.999
M05.9 Seropositive rheumatoid arthritis, unspecified
0.000 0.001 0.999
E10-E14 Diabetes mellitus
0.000 0.001 0.999
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.001 0.999
M35.0 Sicca syndrome [Sjogren]
0.000 0.001 0.999
H36 Retinal disorders in diseases classified elsewhere
0.000 0.001 0.999
M05.90 Seropositive rheumatoid arthritis, unspecified (Multiple sites)
0.000 0.001 0.999
H30-H36 Disorders of choroid and retina
0.000 0.001 0.999
J40-J47 Chronic lower respiratory diseases
0.000 0.001 0.999
G35 Multiple sclerosis
0.000 0.002 0.998
E10.1 With ketoacidosis
0.000 0.003 0.997
J80-J84 Other respiratory diseases principally affecting the interstitium
0.000 0.003 0.997
L80-L99 Other disorders of the skin and subcutaneous tissue
0.000 0.003 0.997
J33.9 Nasal polyp, unspecified
0.000 0.004 0.996
M06.94 Rheumatoid arthritis, unspecified (Hand)
0.000 0.012 0.988
L20-L30 Dermatitis and eczema
0.000 0.013 0.987
H02 Other disorders of eyelid
0.000 0.013 0.987
J20-J22 Other acute lower respiratory infections
0.000 0.016 0.984
M34 Systemic sclerosis
0.000 0.016 0.984
M06.97 Rheumatoid arthritis, unspecified (Ankle and foot)
0.000 0.017 0.983
H04 Disorders of lachrymal system
0.000 0.029 0.971
H02.0 Entropion and trichiasis of eyelid
0.000 0.029 0.971
H55-H59 Other disorders of eye and adnexa
0.000 0.030 0.970
L98 Other disorders of skin and subcutaneous tissue, not elsewhere classified
0.000 0.031 0.969
G35-G37 Demyelinating diseases of the central nervous system
0.000 0.032 0.968
H02.1 Ectropion of eyelid
0.000 0.033 0.967
J22 Unspecified acute lower respiratory infection
0.000 0.035 0.965
E20-E35 Disorders of other endocrine glands
0.000 0.040 0.960
N48 Other disorders of penis
0.960 0.040 0.000
J80 Adult respiratory distress syndrome
0.000 0.040 0.960
N48.6 Balanitis xerotica obliterans
0.958 0.042 0.000
E10.4 With neurological complications
0.000 0.043 0.957
M06.96 Rheumatoid arthritis, unspecified (Lower leg)
0.000 0.043 0.957
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.000 0.048 0.952
J32 Chronic sinusitis
0.000 0.055 0.945
M34.9 Systemic sclerosis, unspecified
0.000 0.058 0.942
L55-L59 Radiation-related disorders of the skin and subcutaneous tissue
0.000 0.062 0.938
E10.5 With peripheral circulatory complications
0.000 0.062 0.938
L98.9 Disorder of skin and subcutaneous tissue, unspecified
0.000 0.063 0.937
H57 Other disorders of eye and adnexa
0.000 0.065 0.935
L40.0 Psoriasis vulgaris
0.935 0.065 0.000
L81 Other disorders of pigmentation
0.000 0.068 0.932
L85 Other epidermal thickening
0.000 0.071 0.929
M05.99 Seropositive rheumatoid arthritis, unspecified (Site unspecified)
0.000 0.072 0.928
M06.0 Seronegative rheumatoid arthritis
0.000 0.072 0.928
L30 Other dermatitis
0.000 0.073 0.927
Chapter VI Diseases of the nervous system
0.000 0.073 0.927
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions
0.000 0.077 0.923
E06 Thyroiditis
0.000 0.077 0.923
H06 Disorders of lachrymal system and orbit in diseases classified elsewhere
0.000 0.080 0.920
J31 Chronic rhinitis, nasopharyngitis and pharyngitis
0.000 0.082 0.918
J81 Pulmonary oedema
0.000 0.088 0.912
E27 Other disorders of adrenal gland
0.000 0.089 0.911
J33.8 Other polyp of sinus
0.000 0.089 0.911
E10.2 With renal complications
0.000 0.094 0.906
J84 Other interstitial pulmonary diseases
0.000 0.097 0.903
L57 Skin changes due to chronic exposure to nonionising radiation
0.000 0.098 0.902
H04.5 Stenosis and insufficiency of lachrymal passages
0.000 0.100 0.900
H15-H22 Disorders of sclera, cornea, iris and ciliary body
0.000 0.101 0.899
M06.91 Rheumatoid arthritis, unspecified (Shoulder region)
0.000 0.102 0.898
L81.4 Other melanin hyperpigmentation
0.000 0.103 0.897
N48.8 Other specified disorders of penis
0.897 0.103 0.000
N48.1 Balanoposthitis
0.895 0.105 0.000
L85.9 Epidermal thickening, unspecified
0.000 0.111 0.889
E27.1 Primary adrenocortical insufficiency
0.000 0.118 0.882
L29 Pruritus
0.000 0.118 0.882
H57.0 Anomalies of pupillary function
0.000 0.122 0.878
M35.1 Other overlap syndromes
0.000 0.125 0.875
N48.0 Leukoplakia of penis
0.867 0.133 0.000
D68 Other coagulation defects
0.000 0.134 0.866
E07 Other disorders of thyroid
0.000 0.135 0.865
H06.2 Dysthyroid exophthalmos
0.000 0.137 0.863
E06.3 Autoimmune thyroiditis
0.000 0.137 0.863
H05 Disorders of orbit
0.000 0.139 0.861
D69 Purpura and other haemorrhagic conditions
0.000 0.139 0.861
L93 Lupus erythematosus
0.000 0.141 0.858
N48.4 Impotence of organic origin
0.858 0.142 0.000
L98.4 Chronic ulcer of skin, not elsewhere classified
0.000 0.142 0.858
M06.3 Rheumatoid nodule
0.000 0.143 0.857
M34.1 CR(E)ST syndrome
0.000 0.145 0.855
J32.0 Chronic maxillary sinusitis
0.000 0.146 0.854
J44 Other chronic obstructive pulmonary disease
0.000 0.148 0.852
J31.0 Chronic rhinitis
0.000 0.148 0.852
L57.8 Other skin changes due to chronic exposure to nonionising radiation
0.000 0.148 0.852
M06.09 Seronegative rheumatoid arthritis (Site unspecified)
0.000 0.152 0.847
L97 Ulcer of lower limb, not elsewhere classified
0.000 0.158 0.842
N48.9 Disorder of penis, unspecified
0.842 0.158 0.000
H04.3 Acute and unspecified inflammation of lachrymal passages
0.000 0.163 0.837
L30.9 Dermatitis, unspecified
0.000 0.166 0.834
M06.4 Inflammatory polyarthropathy
0.000 0.166 0.834
L83 Acanthosis nigricans
0.000 0.167 0.833
J32.9 Chronic sinusitis, unspecified
0.000 0.167 0.833
L21 Seborrhoeic dermatitis
0.000 0.168 0.832
G37 Other demyelinating diseases of central nervous system
0.000 0.172 0.828
H16 Keratitis
0.000 0.176 0.824
E28 Ovarian dysfunction
0.000 0.176 0.824
M34.8 Other forms of systemic sclerosis
0.000 0.177 0.823
E23 Hypofunction and other disorders of pituitary gland
0.000 0.177 0.823
L94 Other localised connective tissue disorders
0.000 0.178 0.822
H55 Nystagmus and other irregular eye movements
0.000 0.179 0.821
D69.3 Idiopathic thrombocytopenic purpura
0.000 0.181 0.819
J82 Pulmonary eosinophilia, not elsewhere classified
0.000 0.184 0.816
M06.93 Rheumatoid arthritis, unspecified (Forearm)
0.000 0.184 0.816
M06.92 Rheumatoid arthritis, unspecified (Upper arm)
0.000 0.187 0.813
H57.8 Other specified disorders of eye and adnexa
0.000 0.192 0.808
D50-D53 Nutritional anaemias
0.000 0.193 0.807
L30.8 Other specified dermatitis
0.000 0.194 0.806
J44.8 Other specified chronic obstructive pulmonary disease
0.000 0.198 0.802
L27 Dermatitis due to substances taken internally
0.000 0.199 0.801
H20 Iridocyclitis
0.000 0.202 0.798
L40-L45 Papulosquamous disorders
0.566 0.203 0.231
J20 Acute bronchitis
0.000 0.203 0.797
J84.9 Interstitial pulmonary disease, unspecified
0.000 0.204 0.796
H33 Retinal detachments and breaks
0.000 0.206 0.794
H04.8 Other disorders of lachrymal system
0.000 0.206 0.794
L98.8 Other specified disorders of skin and subcutaneous tissue
0.000 0.206 0.794
E20 Hypoparathyroidism
0.000 0.210 0.790
L95 Vasculitis limited to skin, not elsewhere classified
0.000 0.211 0.789
H04.1 Other disorders of lachrymal gland
0.000 0.215 0.785
E29 Testicular dysfunction
0.000 0.216 0.784
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.218 0.782
H02.6 Xanthelasma of eyelid
0.000 0.220 0.780
H05.0 Acute inflammation of orbit
0.000 0.221 0.779
H33.2 Serous retinal detachment
0.000 0.221 0.779
E04 Other non-toxic goitre
0.000 0.222 0.778
J32.8 Other chronic sinusitis
0.000 0.222 0.778
H01 Other inflammation of eyelid
0.000 0.225 0.775
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.000 0.227 0.773
G90-G99 Other disorders of the nervous system
0.000 0.228 0.772
M06.34 Rheumatoid nodule (Hand)
0.000 0.229 0.771
L57.0 Actinic keratosis
0.000 0.230 0.770
L29.0 Pruritus ani
0.000 0.234 0.766
E05.8 Other thyrotoxicosis
0.000 0.235 0.765
D68.8 Other specified coagulation defects
0.000 0.239 0.761
H16.0 Corneal ulcer
0.000 0.240 0.760
L93.0 Discoid lupus erythematosus
0.000 0.240 0.760
M06.00 Seronegative rheumatoid arthritis (Multiple sites)
0.000 0.242 0.758
D68.9 Coagulation defect, unspecified
0.000 0.244 0.756
L00-L08 Infections of the skin and subcutaneous tissue
0.000 0.245 0.755
L40.1 Generalised pustular psoriasis
0.755 0.245 0.000
E27.8 Other specified disorders of adrenal gland
0.000 0.251 0.749
M35.7 Hypermobility syndrome
0.000 0.255 0.745
L80 Vitiligo
0.000 0.256 0.744
H03 Disorders of eyelid in diseases classified elsewhere
0.000 0.256 0.744
N40-N51 Diseases of male genital organs
0.741 0.259 0.000
E07.9 Disorder of thyroid, unspecified
0.000 0.261 0.739
J00-J06 Acute upper respiratory infections
0.000 0.262 0.738
G91 Hydrocephalus
0.000 0.262 0.738
N47 Redundant prepuce, phimosis and paraphimosis
0.738 0.262 0.000
L20 Atopic dermatitis
0.000 0.262 0.738
L29.2 Pruritus vulvae
0.000 0.264 0.736
D68.5 Primary Thrombophilia
0.000 0.266 0.734
M45-M49 Spondylopathies
0.001 0.267 0.732
E04.2 Non-toxic multinodular goitre
0.000 0.269 0.731
J21 Acute bronchiolitis
0.000 0.270 0.730
L25 Unspecified contact dermatitis
0.000 0.270 0.730
H04.9 Disorder of lachrymal system, unspecified
0.000 0.271 0.729
J95-J99 Other diseases of the respiratory system
0.000 0.273 0.727
H58 Other disorders of eye and adnexa in diseases classified elsewhere
0.000 0.273 0.727
M45 Ankylosing spondylitis
0.000 0.276 0.724
L21.9 Seborrhoeic dermatitis, unspecified
0.000 0.279 0.721
E26 Hyperaldosteronism
0.000 0.280 0.720
N48.5 Ulcer of penis
0.719 0.281 0.000
M86-M90 Other osteopathies
0.000 0.282 0.718
E05.5 Thyroid crisis or storm
0.000 0.283 0.717
E05.4 Thyrotoxicosis factitia
0.000 0.283 0.717
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.283 0.717
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.283 0.717
E10.8 With unspecified complications
0.000 0.283 0.717
E10.7 With multiple complications
0.000 0.283 0.717
E10.0 With coma
0.000 0.283 0.717
M06.8 Other specified rheumatoid arthritis
0.000 0.283 0.717
M06.2 Rheumatoid bursitis
0.000 0.283 0.717
M06.1 Adult-onset Still's disease
0.000 0.283 0.717
M35.9 Systemic involvement of connective tissue, unspecified
0.000 0.283 0.717
M35.8 Other specified systemic involvement of connective tissue
0.000 0.283 0.717
M35.6 Relapsing panniculitis [Weber-Christian]
0.000 0.283 0.717
M35.5 Multifocal fibrosclerosis
0.000 0.283 0.717
M35.4 Diffuse (eosinophilic) fasciitis
0.000 0.283 0.717
M35.2 Behcet's disease
0.000 0.283 0.717
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.283 0.717
E00 Congenital iodine-deficiency syndrome
0.000 0.283 0.717
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.283 0.717
M09 Juvenile arthritis in diseases classified elsewhere
0.000 0.283 0.717
M08 Juvenile arthritis
0.000 0.283 0.717
Chapter XVI Certain conditions originating in the perinatal period
0.000 0.283 0.717
J33.1 Polypoid sinus degeneration
0.000 0.283 0.717
L40.4 Guttate psoriasis
0.717 0.283 0.000
L40.3 Pustulosis palmaris et plantaris
0.717 0.283 0.000
L40.2 Acrodermatitis continua
0.717 0.283 0.000
E03.5 Myxoedema coma
0.000 0.283 0.717
E03.4 Atrophy of thyroid (acquired)
0.000 0.283 0.717
E03.3 Postinfectious hypothyroidism
0.000 0.283 0.717
E03.1 Congenital hypothyroidism without goitre
0.000 0.283 0.717
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.283 0.717
M05.8 Other seropositive rheumatoid arthritis
0.000 0.283 0.717
M05.3 Rheumatoid arthritis with involvement of other organs and systems
0.000 0.283 0.717
M05.2 Rheumatoid vasculitis
0.000 0.283 0.717
M05.1 Rheumatoid lung disease
0.000 0.283 0.717
M05.0 Felty's syndrome
0.000 0.283 0.717
M36 Systemic disorders of connective tissue in diseases classified elsewhere
0.000 0.283 0.717
M32 Systemic lupus erythematosus
0.000 0.283 0.717
M05.98 Seropositive rheumatoid arthritis, unspecified (Other)
0.000 0.283 0.717
M05.96 Seropositive rheumatoid arthritis, unspecified (Lower leg)
0.000 0.283 0.717
M05.95 Seropositive rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.000 0.283 0.717
M05.94 Seropositive rheumatoid arthritis, unspecified (Hand)
0.000 0.283 0.717
M05.93 Seropositive rheumatoid arthritis, unspecified (Forearm)
0.000 0.283 0.717
M05.92 Seropositive rheumatoid arthritis, unspecified (Upper arm)
0.000 0.283 0.717
M05.91 Seropositive rheumatoid arthritis, unspecified (Shoulder region)
0.000 0.283 0.717
E12 Malnutrition-related diabetes mellitus
0.000 0.283 0.716
H36.8 Other retinal disorders in diseases classified elsewhere
0.000 0.284 0.716
H32 Chorioretinal disorders in diseases classified elsewhere
0.000 0.284 0.716
J41 Simple and mucopurulent chronic bronchitis
0.000 0.284 0.716
E22 Hyperfunction of pituitary gland
0.000 0.285 0.715
L99 Other disorders of skin and subcutaneous tissue in diseases classified elsewhere
0.000 0.285 0.714
L87 Transepidermal elimination disorders
0.000 0.285 0.714
L88 Pyoderma gangrenosum
0.000 0.285 0.714
L86 Keratoderma in diseases classified elsewhere
0.000 0.285 0.714
M45.X9 Ankylosing spondylitis (Site unspecified)
0.000 0.286 0.714
E03.8 Other specified hypothyroidism
0.000 0.286 0.714
M06.98 Rheumatoid arthritis, unspecified (Other)
0.000 0.286 0.714
M60-M63 Disorders of muscles
0.000 0.288 0.711
M22 Disorders of patella
0.000 0.289 0.711
L84 Corns and callosities
0.000 0.290 0.710
M05.97 Seropositive rheumatoid arthritis, unspecified (Ankle and foot)
0.000 0.290 0.710
D69.5 Secondary thrombocytopenia
0.000 0.291 0.709
D80-D89 Certain disorders involving the immune mechanism
0.000 0.291 0.709
D60-D64 Aplastic and other anaemias
0.000 0.291 0.708
D65 Disseminated intravascular coagulation [defibrination syndrome]
0.000 0.292 0.708
L24 Irritant contact dermatitis
0.000 0.292 0.708
L26 Exfoliative dermatitis
0.000 0.292 0.708
L22 Diaper [napkin] dermatitis
0.000 0.292 0.708
J84.8 Other specified interstitial pulmonary diseases
0.000 0.292 0.708
H02.7 Other degenerative disorders of eyelid and periocular area
0.000 0.292 0.707
L28 Lichen simplex chronicus and prurigo
0.000 0.292 0.708
H04.4 Chronic inflammation of lachrymal passages
0.000 0.293 0.707
H57.9 Disorder of eye and adnexa, unspecified
0.000 0.294 0.706
M34.2 Systemic sclerosis induced by drugs and chemicals
0.000 0.295 0.705
M34.0 Progressive systemic sclerosis
0.000 0.295 0.705
M06.40 Inflammatory polyarthropathy (Multiple sites)
0.000 0.296 0.704
H05.2 Exophthalmic conditions
0.000 0.296 0.704
N48.2 Other inflammatory disorders of penis
0.703 0.296 0.000
M30 Polyarteritis nodosa and related conditions
0.000 0.302 0.697
J44.1 Chronic obstructive pulmonary disease with acute exacerbation, unspecified
0.000 0.302 0.698
H04.6 Other changes in lachrymal passages
0.000 0.304 0.696
H04.0 Dacryoadenitis
0.000 0.304 0.696
L98.7 Excessive and redundant skin and subcutaneous tissue
0.000 0.305 0.695
L98.6 Other infiltrative disorders of skin and subcutaneous tissue
0.000 0.305 0.695
L98.3 Eosinophilic cellulitis [Wells]
0.000 0.305 0.695
L98.1 Factitial dermatitis
0.000 0.305 0.695
D69.0 Allergic purpura
0.000 0.305 0.695
G36 Other acute disseminated demyelination
0.000 0.306 0.694
E28.2 Polycystic ovarian syndrome
0.000 0.306 0.694
L56 Other acute skin changes due to ultraviolet radiation
0.000 0.307 0.692
L29.9 Pruritus, unspecified
0.000 0.307 0.693
J84.1 Other interstitial pulmonary diseases with fibrosis
0.000 0.308 0.692
D68.0 Von Willebrand's disease
0.000 0.309 0.691
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.311 0.688
E32 Diseases of thymus
0.000 0.311 0.688
E31 Polyglandular dysfunction
0.000 0.311 0.688
E30 Disorders of puberty, not elsewhere classified
0.000 0.311 0.688
N48.3 Priapism
0.688 0.312 0.000
H30 Chorioretinal inflammation
0.000 0.312 0.687
G37.9 Demyelinating disease of central nervous system, unspecified
0.000 0.312 0.688
J31.2 Chronic pharyngitis
0.000 0.313 0.687
M12 Other specific arthropathies
0.000 0.313 0.687
G91.9 Hydrocephalus, unspecified
0.000 0.317 0.683
E06.9 Thyroiditis, unspecified
0.000 0.320 0.680
H20.8 Other iridocyclitis
0.000 0.321 0.679
L10-L14 Bullous disorders
0.000 0.321 0.678
J32.3 Chronic sphenoidal sinusitis
0.000 0.323 0.677
E07.8 Other specified disorders of thyroid
0.000 0.323 0.677
H18 Other disorders of cornea
0.000 0.323 0.677
J00 Acute nasopharyngitis [common cold]
0.000 0.324 0.676
E10.6 With other specified complications
0.000 0.324 0.676
J20.9 Acute bronchitis, unspecified
0.000 0.324 0.676
L27.0 Generalised skin eruption due to drugs and medicaments
0.000 0.325 0.675
L94.0 Localised scleroderma [morphea]
0.000 0.325 0.675
L02 Cutaneous abscess, furuncle and carbuncle
0.000 0.326 0.674
D50 Iron deficiency anaemia
0.000 0.327 0.673
L58 Radiodermatitis
0.000 0.327 0.672
L55 Sunburn
0.000 0.327 0.672
D52 Folate deficiency anaemia
0.000 0.328 0.672
L81.8 Other specified disorders of pigmentation
0.000 0.329 0.671
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.330 0.670
L81.7 Pigmented purpuric dermatosis
0.000 0.332 0.668
L81.6 Other disorders of diminished melanin formation
0.000 0.332 0.668
L81.5 Leukoderma, not elsewhere classified
0.000 0.332 0.668
L81.3 Cafe au lait spots
0.000 0.332 0.668
L81.2 Freckles
0.000 0.332 0.668
L81.1 Chloasma
0.000 0.332 0.668
L81.0 Postinflammatory hyperpigmentation
0.000 0.332 0.668
L08 Other local infections of skin and subcutaneous tissue
0.000 0.333 0.667
E20.9 Hypoparathyroidism, unspecified
0.000 0.333 0.667
E23.2 Diabetes insipidus
0.000 0.333 0.667
L85.3 Xerosis cutis
0.000 0.334 0.666
L85.2 Keratosis punctata (palmaris et plantaris)
0.000 0.334 0.666
L85.1 Acquired keratosis [keratoderma] palmaris et plantaris
0.000 0.334 0.666
L85.0 Acquired ichthyosis
0.000 0.334 0.666
H57.1 Ocular pain
0.000 0.334 0.666
M06.08 Seronegative rheumatoid arthritis (Other)
0.000 0.335 0.665
M06.07 Seronegative rheumatoid arthritis (Ankle and foot)
0.000 0.335 0.665
M06.06 Seronegative rheumatoid arthritis (Lower leg)
0.000 0.335 0.665
M06.05 Seronegative rheumatoid arthritis (Pelvic region and thigh)
0.000 0.335 0.665
M06.04 Seronegative rheumatoid arthritis (Hand)
0.000 0.335 0.665
M06.03 Seronegative rheumatoid arthritis (Forearm)
0.000 0.335 0.665
M06.02 Seronegative rheumatoid arthritis (Upper arm)
0.000 0.335 0.665
M06.01 Seronegative rheumatoid arthritis (Shoulder region)
0.000 0.335 0.665
L30.5 Pityriasis alba
0.000 0.335 0.665
L30.4 Erythema intertrigo
0.000 0.335 0.665
L30.3 Infective dermatitis
0.000 0.335 0.665
L30.2 Cutaneous autosensitisation
0.000 0.335 0.665
L30.1 Dyshidrosis [pompholyx]
0.000 0.335 0.665
L30.0 Nummular dermatitis
0.000 0.335 0.665
J32.1 Chronic frontal sinusitis
0.000 0.337 0.663
D67 Hereditary factor IX deficiency
0.000 0.338 0.662
E06.5 Other chronic thyroiditis
0.000 0.338 0.661
E06.4 Drug-induced thyroiditis
0.000 0.338 0.661
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.338 0.661
E06.1 Subacute thyroiditis
0.000 0.338 0.661
E06.0 Acute thyroiditis
0.000 0.338 0.661
G37.3 Acute transverse myelitis in demyelinating disease of central nervous system
0.000 0.338 0.661
H06.3 Other disorders of orbit in diseases classified elsewhere
0.000 0.340 0.660
H06.1 Parasitic infestation of orbit in diseases classified elsewhere
0.000 0.340 0.660
H06.0 Disorders of lachrymal system in diseases classified elsewhere
0.000 0.340 0.660
E29.1 Testicular hypofunction
0.000 0.342 0.658
H19 Disorders of sclera and cornea in diseases classified elsewhere
0.000 0.342 0.658
J31.1 Chronic nasopharyngitis
0.000 0.342 0.658
M00-M03 Infectious arthropathies
0.000 0.342 0.658
H31 Other disorders of choroid
0.000 0.345 0.654
E27.5 Adrenomedullary hyperfunction
0.000 0.347 0.653
E27.0 Other adrenocortical overactivity
0.000 0.347 0.653
G91.1 Obstructive hydrocephalus
0.000 0.347 0.653
L98.5 Mucinosis of skin
0.000 0.348 0.652
H02.2 Lagophthalmos
0.000 0.348 0.651
H01.8 Other specified inflammation of eyelid
0.000 0.350 0.650
L82 Seborrhoeic keratosis
0.000 0.350 0.650
E27.9 Disorder of adrenal gland, unspecified
0.000 0.350 0.650
E28.3 Primary ovarian failure
0.000 0.351 0.649
H20.9 Iridocyclitis, unspecified
0.000 0.352 0.648
L57.4 Cutis laxa senilis
0.000 0.353 0.647
J84.0 Alveolar and parietoalveolar conditions
0.000 0.353 0.647
H02.5 Other disorders affecting eyelid function
0.000 0.353 0.647
L57.9 Skin changes due to chronic exposure to nonionising radiation, unspecified
0.000 0.353 0.647
L57.5 Actinic granuloma
0.000 0.353 0.647
L57.3 Poikiloderma of Civatte
0.000 0.353 0.647
L57.2 Cutis rhomboidalis nuchae
0.000 0.353 0.647
L57.1 Actinic reticuloid
0.000 0.353 0.647
M95-M99 Other disorders of the musculoskeletal system and connective tissue
0.000 0.354 0.646
H16.9 Keratitis, unspecified
0.000 0.354 0.646
L40.8 Other psoriasis
0.645 0.354 0.000
E23.6 Other disorders of pituitary gland
0.000 0.355 0.645
L02.2 Cutaneous abscess, furuncle and carbuncle of trunk
0.000 0.357 0.643
L94.2 Calcinosis cutis
0.000 0.360 0.640
M22.2 Patellofemoral disorders
0.000 0.365 0.635
J37 Chronic laryngitis and laryngotracheitis
0.000 0.366 0.634
L23 Allergic contact dermatitis
0.000 0.367 0.632
L29.1 Pruritus scroti
0.000 0.368 0.632
N45 Orchitis and epididymitis
0.632 0.368 0.000
D68.6 Other Thrombophilia
0.000 0.370 0.630
J44.0 Chronic obstructive pulmonary disease with acute lower respiratory infection
0.000 0.371 0.629
D61 Other aplastic anaemias
0.000 0.372 0.628
J32.4 Chronic pansinusitis
0.000 0.373 0.627
L29.8 Other pruritus
0.000 0.374 0.626
E16 Other disorders of pancreatic internal secretion
0.000 0.374 0.626
M89 Other disorders of bone
0.000 0.374 0.626
H15 Disorders of sclera
0.000 0.375 0.625
M21 Other acquired deformities of limbs
0.000 0.375 0.625
E14 Unspecified diabetes mellitus
0.000 0.376 0.624
M33 Dermatopolymyositis
0.000 0.376 0.623
J95 Postprocedural respiratory disorders, not elsewhere classified
0.000 0.377 0.623
G80-G83 Cerebral palsy and other paralytic syndromes
0.000 0.378 0.622
D68.4 Acquired coagulation factor deficiency
0.000 0.379 0.621
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.379 0.620
E07.1 Dyshormogenetic goitre
0.000 0.380 0.620
E07.0 Hypersecretion of calcitonin
0.000 0.380 0.620
H05.8 Other disorders of orbit
0.000 0.380 0.620
E22.0 Acromegaly and pituitary gigantism
0.000 0.380 0.620
L08.9 Local infection of skin and subcutaneous tissue, unspecified
0.000 0.380 0.620
H05.5 Retained (old) foreign body following penetrating wound of orbit
0.000 0.383 0.617
H05.3 Deformity of orbit
0.000 0.383 0.617
E50-E64 Other nutritional deficiencies
0.000 0.383 0.617
M06.49 Inflammatory polyarthropathy (Site unspecified)
0.000 0.383 0.617
D69.8 Other specified haemorrhagic conditions
0.000 0.383 0.617
D69.4 Other primary thrombocytopenia
0.000 0.383 0.617
D69.1 Qualitative platelet defects
0.000 0.383 0.617
E27.3 Drug-induced adrenocortical insufficiency
0.000 0.384 0.616
M11 Other crystal arthropathies
0.000 0.384 0.616
L93.2 Other local lupus erythematosus
0.000 0.384 0.615
L93.1 Subacute cutaneous lupus erythematosus
0.000 0.384 0.615
E04.0 Non-toxic diffuse goitre
0.000 0.384 0.616
M06.39 Rheumatoid nodule (Site unspecified)
0.000 0.386 0.614
M06.38 Rheumatoid nodule (Other)
0.000 0.386 0.614
M06.36 Rheumatoid nodule (Lower leg)
0.000 0.386 0.614
M06.35 Rheumatoid nodule (Pelvic region and thigh)
0.000 0.386 0.614
M06.33 Rheumatoid nodule (Forearm)
0.000 0.386 0.614
M06.31 Rheumatoid nodule (Shoulder region)
0.000 0.386 0.614
M06.30 Rheumatoid nodule (Multiple sites)
0.000 0.386 0.614
H02.9 Disorder of eyelid, unspecified
0.000 0.386 0.614
E34 Other endocrine disorders
0.000 0.387 0.613
E23.7 Disorder of pituitary gland, unspecified
0.000 0.388 0.612
L44 Other papulosquamous disorders
0.471 0.389 0.140
H33.4 Traction detachment of retina
0.000 0.389 0.611
L85.8 Other specified epidermal thickening
0.000 0.389 0.611
D68.1 Hereditary factor XI deficiency
0.000 0.389 0.610
L95.8 Other vasculitis limited to skin
0.000 0.390 0.610
M31 Other necrotising vasculopathies
0.000 0.390 0.610
E23.0 Hypopituitarism
0.000 0.391 0.609
H59 Postprocedural disorders of eye and adnexa, not elsewhere classified
0.000 0.392 0.608
L98.0 Pyogenic granuloma
0.000 0.393 0.607
J01 Acute sinusitis
0.000 0.395 0.605
H10-H13 Disorders of conjunctiva
0.000 0.395 0.605
E27.2 Addisonian crisis
0.000 0.395 0.605
H02.4 Ptosis of eyelid
0.000 0.396 0.604
L95.9 Vasculitis limited to skin, unspecified
0.000 0.396 0.603
J60-J70 Lung diseases due to external agents
0.000 0.397 0.602
H18.6 Keratoconus
0.000 0.398 0.602
D50.8 Other iron deficiency anaemias
0.000 0.398 0.602
M06.48 Inflammatory polyarthropathy (Other)
0.000 0.402 0.598
M06.47 Inflammatory polyarthropathy (Ankle and foot)
0.000 0.402 0.598
M06.46 Inflammatory polyarthropathy (Lower leg)
0.000 0.402 0.598
M06.45 Inflammatory polyarthropathy (Pelvic region and thigh)
0.000 0.402 0.598
M06.44 Inflammatory polyarthropathy (Hand)
0.000 0.402 0.598
M06.43 Inflammatory polyarthropathy (Forearm)
0.000 0.402 0.598
M06.42 Inflammatory polyarthropathy (Upper arm)
0.000 0.402 0.598
M06.41 Inflammatory polyarthropathy (Shoulder region)
0.000 0.402 0.598
L21.8 Other seborrhoeic dermatitis
0.000 0.403 0.597
L21.1 Seborrhoeic infantile dermatitis
0.000 0.403 0.597
L21.0 Seborrhoea capitis
0.000 0.403 0.597
M06.32 Rheumatoid nodule (Upper arm)
0.000 0.405 0.595
G37.8 Other specified demyelinating diseases of central nervous system
0.000 0.406 0.594
G37.5 Concentric sclerosis [Balo]
0.000 0.406 0.594
G37.4 Subacute necrotising myelitis
0.000 0.406 0.594
G37.2 Central pontine myelinolysis
0.000 0.406 0.594
G37.1 Central demyelination of corpus callosum
0.000 0.406 0.594
G37.0 Diffuse sclerosis
0.000 0.406 0.594
M14 Arthropathies in other diseases classified elsewhere
0.000 0.406 0.593
H20.0 Acute and subacute iridocyclitis
0.000 0.409 0.591
H16.8 Other keratitis
0.000 0.409 0.591
H16.4 Corneal neovascularisation
0.000 0.409 0.591
H16.3 Interstitial and deep keratitis
0.000 0.409 0.591
H16.1 Other superficial keratitis without conjunctivitis
0.000 0.409 0.591
E28.9 Ovarian dysfunction, unspecified
0.000 0.409 0.591
E28.8 Other ovarian dysfunction
0.000 0.409 0.591
E28.1 Androgen excess
0.000 0.409 0.591
E28.0 Oestrogen excess
0.000 0.409 0.591
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.000 0.410 0.590
E23.1 Drug-induced hypopituitarism
0.000 0.410 0.590
L94.8 Other specified localised connective tissue disorders
0.000 0.410 0.589
L94.6 Ainhum
0.000 0.410 0.589
L94.5 Poikiloderma vasculare atrophicans
0.000 0.410 0.589
L94.4 Gottron's papules
0.000 0.410 0.589
L94.3 Sclerodactyly
0.000 0.410 0.589
L94.1 Linear scleroderma
0.000 0.410 0.589
L02.4 Cutaneous abscess, furuncle and carbuncle of limb
0.000 0.412 0.588
L59 Other disorders of skin and subcutaneous tissue related to radiation
0.000 0.412 0.588
J32.2 Chronic ethmoidal sinusitis
0.000 0.412 0.587
E40-E46 Malnutrition
0.000 0.413 0.587
M06.37 Rheumatoid nodule (Ankle and foot)
0.000 0.413 0.587
E65-E68 Obesity and other hyperalimentation
0.000 0.414 0.586
N44 Torsion of testis
0.582 0.418 0.000
E25 Adrenogenital disorders
0.000 0.418 0.581
M45.X0 Ankylosing spondylitis (Multiple sites in spine)
0.000 0.418 0.581
H02.8 Other specified disorders of eyelid
0.000 0.419 0.581
G97 Postprocedural disorders of nervous system, not elsewhere classified
0.000 0.421 0.579
M65-M68 Disorders of synovium and tendon
0.000 0.422 0.578
G80 Infantile cerebral palsy
0.000 0.423 0.577
D52.9 Folate deficiency anaemia, unspecified
0.000 0.425 0.575
J85-J86 Suppurative and necrotic conditions of lower respiratory tract
0.000 0.425 0.575

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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