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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs2844494
log Bayes Factor = 89.3891
Chromosome 6   position 31,483,415  (GRCh37) Explore rs2844494 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E03.9 Hypothyroidism, unspecified
0.000 0.000 1.000
E10.9 Without complications
0.000 0.000 1.000
E10.3 With ophthalmic complications
0.000 0.000 1.000
K90.0 Coeliac disease
0.000 0.000 1.000
L40.9 Psoriasis, unspecified
1.000 0.000 0.000
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
E00-E07 Disorders of thyroid gland
0.000 0.000 1.000
E10-E14 Diabetes mellitus
0.000 0.000 1.000
E05.9 Thyrotoxicosis, unspecified
0.000 0.000 1.000
E03 Other hypothyroidism
0.000 0.000 1.000
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.000 1.000
E14 Unspecified diabetes mellitus
0.000 0.001 0.999
M06.9 Rheumatoid arthritis, unspecified
0.000 0.001 0.999
M45.X9 Ankylosing spondylitis (Site unspecified)
0.000 0.001 0.999
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.001 0.999
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)
0.000 0.003 0.997
E10.1 With ketoacidosis
0.000 0.005 0.995
E10.4 With neurological complications
0.000 0.006 0.994
M45 Ankylosing spondylitis
0.000 0.009 0.991
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)
0.000 0.014 0.986
E14.9 Without complications
0.000 0.016 0.984
E14.3 With ophthalmic complications
0.000 0.017 0.983
I20.9 Angina pectoris, unspecified
0.000 0.029 0.971
I20 Angina pectoris
0.000 0.031 0.969
I20-I25 Ischaemic heart diseases
0.000 0.032 0.968
I22 Subsequent myocardial infarction
0.000 0.037 0.963
M45.X0 Ankylosing spondylitis (Multiple sites in spine)
0.000 0.044 0.956
M06.94 Rheumatoid arthritis, unspecified (Hand)
0.000 0.048 0.952
M35.0 Sicca syndrome [Sjogren]
0.000 0.050 0.950
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.051 0.949
M45.X2 Ankylosing spondylitis (Cervical region)
0.000 0.053 0.947
M35 Other systemic involvement of connective tissue
0.000 0.058 0.942
I25 Chronic ischaemic heart disease
0.000 0.064 0.936
M06.92 Rheumatoid arthritis, unspecified (Upper arm)
0.000 0.068 0.932
I22.9 Subsequent myocardial infarction of unspecified site
0.000 0.068 0.932
I22.1 Subsequent myocardial infarction of inferior wall
0.000 0.071 0.929
I25.1 Atherosclerotic heart disease
0.000 0.072 0.928
L40 Psoriasis
0.926 0.074 0.000
E06 Thyroiditis
0.000 0.080 0.920
E16 Other disorders of pancreatic internal secretion
0.000 0.086 0.914
M06.96 Rheumatoid arthritis, unspecified (Lower leg)
0.000 0.088 0.912
I25.5 Ischaemic cardiomyopathy
0.000 0.089 0.911
E10.2 With renal complications
0.000 0.093 0.907
L40.0 Psoriasis vulgaris
0.895 0.105 0.000
E10.0 With coma
0.000 0.122 0.878
M35.1 Other overlap syndromes
0.000 0.124 0.876
M06.98 Rheumatoid arthritis, unspecified (Other)
0.000 0.135 0.865
E10.5 With peripheral circulatory complications
0.000 0.142 0.858
E06.3 Autoimmune thyroiditis
0.000 0.145 0.855
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.147 0.853
I20.0 Unstable angina
0.000 0.158 0.842
M06.97 Rheumatoid arthritis, unspecified (Ankle and foot)
0.000 0.162 0.838
M34 Systemic sclerosis
0.000 0.164 0.836
M20-M25 Other joint disorders
0.000 0.169 0.831
M35.2 Behcet's disease
0.000 0.172 0.828
E16.2 Hypoglycaemia, unspecified
0.000 0.173 0.827
M06 Other rheumatoid arthritis
0.000 0.174 0.826
M34.1 CR(E)ST syndrome
0.000 0.182 0.818
E14.6 With other specified complications
0.000 0.183 0.817
E14.8 With unspecified complications
0.000 0.186 0.814
M35.3 Polymyalgia rheumatica
0.000 0.189 0.811
I23 Certain current complications following acute myocardial infarction
0.000 0.191 0.809
M34.9 Systemic sclerosis, unspecified
0.000 0.201 0.799
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.000 0.202 0.798
I20.1 Angina pectoris with documented spasm
0.000 0.214 0.786
M06.91 Rheumatoid arthritis, unspecified (Shoulder region)
0.000 0.234 0.766
I22.0 Subsequent myocardial infarction of anterior wall
0.000 0.243 0.757
M23.33 Other meniscus derangements (Medial collateral ligament or Other and unspecified medial meniscus)
0.000 0.246 0.754
M23.3 Other meniscus derangements
0.000 0.249 0.751
L40.5 Arthropathic psoriasis
0.751 0.249 0.000
M34.8 Other forms of systemic sclerosis
0.000 0.254 0.746
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.255 0.745
M23 Internal derangement of knee
0.000 0.258 0.742
I24 Other acute ischaemic heart diseases
0.000 0.270 0.730
E14.4 With neurological complications
0.000 0.277 0.723
E14.1 With ketoacidosis
0.000 0.279 0.721
E05.5 Thyroid crisis or storm
0.000 0.283 0.717
E05.4 Thyrotoxicosis factitia
0.000 0.283 0.717
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.283 0.717
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.283 0.717
E10.7 With multiple complications
0.000 0.283 0.717
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.283 0.717
E00 Congenital iodine-deficiency syndrome
0.000 0.283 0.717
E12 Malnutrition-related diabetes mellitus
0.000 0.283 0.717
E03.5 Myxoedema coma
0.000 0.283 0.717
E03.4 Atrophy of thyroid (acquired)
0.000 0.283 0.717
E03.3 Postinfectious hypothyroidism
0.000 0.283 0.717
E14.7 With multiple complications
0.000 0.283 0.716
E14.5 With peripheral circulatory complications
0.000 0.284 0.716
E10.8 With unspecified complications
0.000 0.284 0.716
E13 Other specified diabetes mellitus
0.000 0.288 0.712
E14.2 Withrenal complications
0.000 0.289 0.711
M45.X8 Ankylosing spondylitis (Sacral and sacrococcygeal region)
0.000 0.290 0.710
M45.X7 Ankylosing spondylitis (Lumbosacral region)
0.000 0.290 0.710
M45.X6 Ankylosing spondylitis (Lumbar region)
0.000 0.290 0.710
M45.X5 Ankylosing spondylitis (Thoracolumbar region)
0.000 0.290 0.710
M45.X4 Ankylosing spondylitis (Thoracic region)
0.000 0.290 0.710
M45.X3 Ankylosing spondylitis (Cervicothoracic region)
0.000 0.290 0.710
M45.X1 Ankylosing spondylitis (Occipito-atlanto-axial region)
0.000 0.290 0.710
E83.1 Disorders of iron metabolism
0.709 0.291 0.000
L40.1 Generalised pustular psoriasis
0.701 0.299 0.000
I23.8 Other current complications following acute myocardial infarction
0.000 0.305 0.695
M06.93 Rheumatoid arthritis, unspecified (Forearm)
0.000 0.311 0.689
E06.9 Thyroiditis, unspecified
0.000 0.311 0.689
M45-M49 Spondylopathies
0.000 0.315 0.685
M35.8 Other specified systemic involvement of connective tissue
0.000 0.316 0.684
M22 Disorders of patella
0.000 0.316 0.684
E15 Nondiabetic hypoglycaemic coma
0.000 0.319 0.681
M35.9 Systemic involvement of connective tissue, unspecified
0.000 0.325 0.675
M35.6 Relapsing panniculitis [Weber-Christian]
0.000 0.325 0.675
M35.5 Multifocal fibrosclerosis
0.000 0.325 0.675
M35.4 Diffuse (eosinophilic) fasciitis
0.000 0.325 0.675
Chapter XIII Diseases of the musculoskeletal system and connective tissue
0.000 0.328 0.672
M05-M14 Inflammatory polyarthropathies
0.000 0.328 0.672
I25.6 Silent myocardial ischaemia
0.000 0.329 0.671
M35.7 Hypermobility syndrome
0.000 0.330 0.670
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.331 0.669
L40.4 Guttate psoriasis
0.664 0.336 0.000
L40.2 Acrodermatitis continua
0.664 0.336 0.000
M06.0 Seronegative rheumatoid arthritis
0.000 0.336 0.664
E06.5 Other chronic thyroiditis
0.000 0.340 0.659
E06.4 Drug-induced thyroiditis
0.000 0.340 0.659
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.340 0.659
E06.1 Subacute thyroiditis
0.000 0.340 0.659
E06.0 Acute thyroiditis
0.000 0.340 0.659
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.345 0.655
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.345 0.655
E16.4 Abnormal secretion of gastrin
0.000 0.345 0.655
E16.3 Increased secretion of glucagon
0.000 0.345 0.655
M23.34 Other meniscus derangements (Lateral collateral ligament or Anterior horn of lateral meniscus)
0.000 0.348 0.652
L40.3 Pustulosis palmaris et plantaris
0.651 0.349 0.000
E10.6 With other specified complications
0.000 0.349 0.651
M32 Systemic lupus erythematosus
0.000 0.349 0.650
M06.3 Rheumatoid nodule
0.000 0.350 0.650
M23.36 Other meniscus derangements (Other and unspecified lateral meniscus)
0.000 0.355 0.645
E40-E46 Malnutrition
0.000 0.365 0.635
L40.8 Other psoriasis
0.634 0.365 0.000
M06.09 Seronegative rheumatoid arthritis (Site unspecified)
0.000 0.367 0.633
I21 Acute myocardial infarction
0.000 0.367 0.633
M23.39 Other meniscus derangements (Unspecified ligament or Unspecified meniscus)
0.000 0.370 0.630
I25.8 Other forms of chronic ischaemic heart disease
0.000 0.377 0.623
E65-E68 Obesity and other hyperalimentation
0.000 0.377 0.623
E14.0 With coma
0.000 0.381 0.619
M23.35 Other meniscus derangements (Posterior horn of lateral meniscus)
0.000 0.382 0.618
I21.2 Acute transmural myocardial infarction of other sites
0.000 0.387 0.613
M34.0 Progressive systemic sclerosis
0.000 0.387 0.613
I24.9 Acute ischaemic heart disease, unspecified
0.000 0.388 0.612
M22.8 Other disorders of patella
0.000 0.394 0.606
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.394 0.606
I22.8 Subsequent myocardial infarction of other sites
0.000 0.397 0.603
E07 Other disorders of thyroid
0.000 0.401 0.599
M34.2 Systemic sclerosis induced by drugs and chemicals
0.000 0.401 0.599
E16.1 Other hypoglycaemia
0.000 0.405 0.595
G35 Multiple sclerosis
0.595 0.405 0.000
M06.8 Other specified rheumatoid arthritis
0.000 0.408 0.592
M06.2 Rheumatoid bursitis
0.000 0.408 0.592
M06.1 Adult-onset Still's disease
0.000 0.408 0.592
M06.34 Rheumatoid nodule (Hand)
0.000 0.414 0.586
E03.1 Congenital hypothyroidism without goitre
0.000 0.415 0.585
M36 Systemic disorders of connective tissue in diseases classified elsewhere
0.000 0.416 0.584
M22.9 Disorder of patella, unspecified
0.000 0.419 0.581
I23.6 Thrombosis of atrium, auricular appendage and ventricle as current complications following acute myocardial infarction
0.000 0.420 0.580
I23.5 Rupture of papillary muscle as current complication following acute myocardial infarction
0.000 0.420 0.580
I23.4 Rupture of chordae tendineae as current complication following acute myocardial infarction
0.000 0.420 0.580
I23.3 Rupture of cardiac wall without haemopericardium as current complication following acute myocardial infarction
0.000 0.420 0.580
I23.2 Ventricular septal defect as current complication following acute myocardial infarction
0.000 0.420 0.580
I23.1 Atrial septal defect as current complication following acute myocardial infarction
0.000 0.420 0.580
I23.0 Haemopericardium as current complication following acute myocardial infarction
0.000 0.420 0.580
I25.3 Aneurysm of heart
0.000 0.424 0.576
I25.4 Coronary artery aneurysm
0.000 0.449 0.551
M22.3 Other derangements of patella
0.000 0.450 0.550
E05.8 Other thyrotoxicosis
0.000 0.451 0.549
I21.9 Acute myocardial infarction, unspecified
0.000 0.453 0.547
E03.8 Other specified hypothyroidism
0.000 0.454 0.546
M23.37 Other meniscus derangements-Capsular lig
0.000 0.461 0.539
E65 Localised adiposity
0.000 0.467 0.533
M23.32 Other meniscus derangements (Posterior cruciate ligament or Posterior horn of medial meniscus)
0.000 0.468 0.532
E13.3 With ophthalmic complications
0.000 0.468 0.532
I24.0 Coronary thrombosis not resulting in myocardial infarction
0.000 0.475 0.525
I25.0 Atherosclerotic cardiovascular disease, so described
0.000 0.482 0.518
M49 Spondylopathies in diseases classified elsewhere
0.000 0.482 0.518
M32.1 Systemic lupus erythematosus with organ or system involvement
0.000 0.485 0.515
G35-G37 Demyelinating diseases of the central nervous system
0.515 0.485 0.000
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.000 0.486 0.514
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.000 0.486 0.514
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.000 0.486 0.514
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.000 0.486 0.514
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.486 0.514
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.000 0.486 0.514
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.000 0.486 0.514
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.000 0.486 0.514
E12.9 Without complications
0.000 0.486 0.514
E12.8 With unspecified complications
0.000 0.486 0.514
E12.7 With multiple complications
0.000 0.486 0.514
E12.6 With other specified complications
0.000 0.486 0.514
E12.5 With peripheral circulatory complications
0.000 0.486 0.514
E12.4 With neurological complications
0.000 0.486 0.514
E12.3 With ophthalmic complications
0.000 0.486 0.514
E12.2 With renal complications
0.000 0.486 0.514
E12.1 With ketoacidosis
0.000 0.486 0.514
E12.0 With coma
0.000 0.486 0.514
M30 Polyarteritis nodosa and related conditions
0.000 0.486 0.514
E13.8 With unspecified complications
0.000 0.489 0.511
E13.7 With multiple complications
0.000 0.489 0.511
E13.6 With other specified complications
0.000 0.489 0.511
E13.5 With peripheral circulatory complications
0.000 0.489 0.511
E13.4 With neurological complications
0.000 0.489 0.511
E13.2 With renal complications
0.000 0.489 0.511
E13.1 With ketoacidosis
0.000 0.489 0.511
E13.0 With coma
0.000 0.489 0.511
G37 Other demyelinating diseases of central nervous system
0.502 0.498 0.000
M22.0 Recurrent dislocation of patella
0.000 0.504 0.496
I24.1 Dressler's syndrome
0.000 0.505 0.495
M22.1 Recurrent subluxation of patella
0.000 0.510 0.490
G37.9 Demyelinating disease of central nervous system, unspecified
0.489 0.511 0.000
M06.32 Rheumatoid nodule (Upper arm)
0.000 0.514 0.486
M35.99 Systemic involvement of connective tissue, unspecified, Site unspecified
0.000 0.516 0.484
M33 Dermatopolymyositis
0.000 0.517 0.482
E13.9 Without complications
0.000 0.518 0.482
M09 Juvenile arthritis in diseases classified elsewhere
0.000 0.518 0.482
M80-M85 Disorders of bone density and structure
0.000 0.520 0.480
M23.6 Other spontaneous disruption of ligament(s) of knee
0.000 0.521 0.478
M06.08 Seronegative rheumatoid arthritis (Other)
0.000 0.524 0.476
M06.05 Seronegative rheumatoid arthritis (Pelvic region and thigh)
0.000 0.524 0.476
M06.04 Seronegative rheumatoid arthritis (Hand)
0.000 0.524 0.476
M06.03 Seronegative rheumatoid arthritis (Forearm)
0.000 0.524 0.476
M06.02 Seronegative rheumatoid arthritis (Upper arm)
0.000 0.524 0.476
M23.5 Chronic instability of knee
0.000 0.524 0.476
E11 Non-insulin-dependent diabetes mellitus
0.000 0.525 0.475
M32.8 Other forms of systemic lupus erythematosus
0.000 0.526 0.474
M23.4 Loose body in knee
0.000 0.529 0.471
M06.07 Seronegative rheumatoid arthritis (Ankle and foot)
0.000 0.531 0.469
M06.4 Inflammatory polyarthropathy
0.000 0.532 0.467
I24.8 Other forms of acute ischaemic heart disease
0.000 0.533 0.467
M32.9 Systemic lupus erythematosus, unspecified
0.000 0.533 0.466
M32.0 Drug-induced systemic lupus erythematosus
0.000 0.533 0.466
M06.39 Rheumatoid nodule (Site unspecified)
0.000 0.534 0.466
M06.38 Rheumatoid nodule (Other)
0.000 0.534 0.466
M06.36 Rheumatoid nodule (Lower leg)
0.000 0.534 0.466
M06.35 Rheumatoid nodule (Pelvic region and thigh)
0.000 0.534 0.466
M06.31 Rheumatoid nodule (Shoulder region)
0.000 0.534 0.466
M08 Juvenile arthritis
0.000 0.535 0.465
M23.9 Internal derangement of knee, unspecified
0.000 0.536 0.464
M05 Seropositive rheumatoid arthritis
0.000 0.544 0.456
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.545 0.455
E45 Retarded development following protein-energy malnutrition
0.000 0.545 0.455
E43 Unspecified severe protein-energy malnutrition
0.000 0.545 0.455
E42 Marasmic kwashiorkor
0.000 0.545 0.455
E41 Nutritional marasmus
0.000 0.545 0.455
E40 Kwashiorkor
0.000 0.545 0.455
I21.X Presumed acute myicardial infaction (unconfirmed)
0.000 0.546 0.454
M82 Osteoporosis in diseases classified elsewhere
0.000 0.550 0.450
K90 Intestinal malabsorption
0.000 0.551 0.449
M23.0 Cystic meniscus
0.000 0.552 0.448
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.552 0.447
E67 Other hyperalimentation
0.000 0.553 0.447
E68 Sequelae of hyperalimentation
0.000 0.553 0.447
M80 Osteoporosis with pathological fracture
0.000 0.554 0.446
M06.30 Rheumatoid nodule (Multiple sites)
0.000 0.565 0.435
E11.0 With coma
0.000 0.565 0.435
M80.9 Unspecified osteoporosis with pathological fracture
0.000 0.569 0.431
E07.1 Dyshormogenetic goitre
0.000 0.570 0.430
E07.0 Hypersecretion of calcitonin
0.000 0.570 0.430
M82.1 Osteoporosis in endocrine disorders
0.000 0.571 0.429
M06.19 Adult-onset Still's disease (Site unspecified)
0.000 0.575 0.425
M06.18 Adult-onset Still's disease (Other)
0.000 0.575 0.425
M06.17 Adult-onset Still's disease (Ankle and foot)
0.000 0.575 0.425
M06.16 Adult-onset Still's disease (Lower leg)
0.000 0.575 0.425
M06.15 Adult-onset Still's disease (Pelvic region and thigh)
0.000 0.575 0.425
M06.14 Adult-onset Still's disease (Hand)
0.000 0.575 0.425
M06.13 Adult-onset Still's disease (Forearm)
0.000 0.575 0.425
M06.12 Adult-onset Still's disease (Upper arm)
0.000 0.575 0.425
M06.11 Adult-onset Still's disease (Shoulder region)
0.000 0.575 0.425
M06.10 Adult-onset Still's disease (Multiple sites)
0.000 0.575 0.425
M06.29 Rheumatoid bursitis (Site unspecified)
0.000 0.575 0.425
M06.28 Rheumatoid bursitis (Other)
0.000 0.575 0.425
M06.27 Rheumatoid bursitis (Ankle and foot)
0.000 0.575 0.425
M06.26 Rheumatoid bursitis (Lower leg)
0.000 0.575 0.425
M06.25 Rheumatoid bursitis (Pelvic region and thigh)
0.000 0.575 0.425
M06.24 Rheumatoid bursitis (Hand)
0.000 0.575 0.425
M06.23 Rheumatoid bursitis (Forearm)
0.000 0.575 0.425
M06.22 Rheumatoid bursitis (Upper arm)
0.000 0.575 0.425
M06.21 Rheumatoid bursitis (Shoulder region)
0.000 0.575 0.425
M06.20 Rheumatoid bursitis (Multiple sites)
0.000 0.575 0.425
M06.89 Other specified rheumatoid arthritis (Site unspecified)
0.000 0.575 0.425
M06.88 Other specified rheumatoid arthritis (Other)
0.000 0.575 0.425
M06.87 Other specified rheumatoid arthritis (Ankle and foot)
0.000 0.575 0.425
M06.86 Other specified rheumatoid arthritis (Lower leg)
0.000 0.575 0.425
M06.85 Other specified rheumatoid arthritis (Pelvic region and thigh)
0.000 0.575 0.425
M06.84 Other specified rheumatoid arthritis (Hand)
0.000 0.575 0.425
M06.83 Other specified rheumatoid arthritis (Forearm)
0.000 0.575 0.425
M06.82 Other specified rheumatoid arthritis (Upper arm)
0.000 0.575 0.425
M06.81 Other specified rheumatoid arthritis (Shoulder region)
0.000 0.575 0.425
M06.80 Other specified rheumatoid arthritis (Multiple sites)
0.000 0.575 0.425
M23.1 Discoid meniscus (congenital)
0.000 0.580 0.420
E50-E64 Other nutritional deficiencies
0.000 0.581 0.419
M23.31 Other meniscus derangements (Anterior cruciate ligament or Anterior horn of medial meniscus)
0.000 0.581 0.419
M36.4 Arthropathy in hypersensitivity reactions classified elsewhere
0.000 0.581 0.418
M36.3 Arthropathy in other blood disorders
0.000 0.581 0.418
M36.2 Haemophilic arthropathy
0.000 0.581 0.418
M36.1 Arthropathy in neoplastic disease
0.000 0.581 0.418
M36.0 Dermato(poly)myositis in neoplastic disease
0.000 0.581 0.418
M06.00 Seronegative rheumatoid arthritis (Multiple sites)
0.000 0.584 0.416
E11.9 Without complications
0.000 0.589 0.411
M80.98 Unspecified osteoporosis with pathological fracture (Other)
0.000 0.591 0.409
M36.8 Systemic disorders of connective tissue in other diseases classified elsewhere
0.000 0.594 0.406
M70-M79 Other soft tissue disorders
0.000 0.594 0.406
M11 Other crystal arthropathies
0.000 0.596 0.404
M12 Other specific arthropathies
0.000 0.596 0.404
M30.0 Polyarteritis nodosa
0.000 0.596 0.403
M06.33 Rheumatoid nodule (Forearm)
0.000 0.598 0.402
M49.5 Collapsed vertebra in diseases classified elsewhere
0.000 0.602 0.398
M82.10 Osteoporosis in endocrine disorders (Multiple sites)
0.000 0.608 0.392
M06.37 Rheumatoid nodule (Ankle and foot)
0.000 0.608 0.391
M06.01 Seronegative rheumatoid arthritis (Shoulder region)
0.000 0.612 0.388
G37.8 Other specified demyelinating diseases of central nervous system
0.388 0.612 0.000
H36.0 Diabetic retinopathy
0.000 0.618 0.382
M70 Soft tissue disorders related to use, overuse and pressure
0.000 0.620 0.380
E07.8 Other specified disorders of thyroid
0.000 0.621 0.379
E07.9 Disorder of thyroid, unspecified
0.000 0.623 0.377
M82.11 Osteoporosis in endocrine disorders (Shoulder region)
0.000 0.623 0.377
E46 Unspecified protein-energy malnutrition
0.000 0.626 0.374
G37.3 Acute transverse myelitis in demyelinating disease of central nervous system
0.374 0.626 0.000
M49.8 Spondylopathy in other diseases classified elsewhere
0.000 0.629 0.371
M49.4 Neuropathic spondylopathy
0.000 0.629 0.371
M49.3 Spondylopathy in other infectious and parasitic diseases classified elsewhere
0.000 0.629 0.371
M49.2 Enterobacterial spondylitis
0.000 0.629 0.371
M49.1 Brucella spondylitis
0.000 0.629 0.371
M49.0 Tuberculosis of spine
0.000 0.629 0.371
M30.8 Other conditions related to polyarteritis nodosa
0.000 0.631 0.369
M30.3 Mucocutaneous lymph node syndrome [Kawasaki]
0.000 0.631 0.369
M30.2 Juvenile polyarteritis
0.000 0.631 0.369
M80.90 Unspecified osteoporosis with pathological fracture (Multiple sites)
0.000 0.632 0.368
K90.9 Intestinal malabsorption, unspecified
0.000 0.634 0.366
M80.1 Postoophorectomy osteoporosis with pathological fracture
0.000 0.635 0.365
M00-M03 Infectious arthropathies
0.000 0.638 0.362
M70.4 Prepatellar bursitis
0.000 0.640 0.360
G37.5 Concentric sclerosis [Balo]
0.360 0.640 0.000
G37.4 Subacute necrotising myelitis
0.360 0.640 0.000
G37.2 Central pontine myelinolysis
0.360 0.640 0.000
G37.1 Central demyelination of corpus callosum
0.360 0.640 0.000
G37.0 Diffuse sclerosis
0.360 0.640 0.000
M10 Gout
0.000 0.643 0.357
M23.51 Chronic instability of knee (Anterior cruciate ligament or Anterior horn of medial meniscus)
0.000 0.645 0.355
M14 Arthropathies in other diseases classified elsewhere
0.000 0.645 0.355
M23.46 Loose body in knee-O/unsp lat men
0.000 0.646 0.354
M23.04 Cystic meniscus (Lateral collateral ligament or Anterior horn of lateral meniscus)
0.000 0.646 0.353
M22.10 Recurrent subluxation of patella, unspecified knee
0.000 0.648 0.351
M95-M99 Other disorders of the musculoskeletal system and connective tissue
0.000 0.649 0.351
M05.8 Other seropositive rheumatoid arthritis
0.000 0.652 0.348
M23.43 Loose body in knee-Med lig/oth men
0.000 0.652 0.348
M06.40 Inflammatory polyarthropathy (Multiple sites)
0.000 0.652 0.347
M23.41 Loose body in knee-Ant lig/hrn men
0.000 0.653 0.347
M33.9 Dermatopolymyositis, unspecified
0.000 0.654 0.346
M33.0 Juvenile dermatomyositis
0.000 0.654 0.346
M70.46 Prepatellar bursitis-Lower Leg
0.000 0.654 0.346
M09.8 Juvenile arthritis in other diseases classified elsewhere
0.000 0.654 0.345
M09.2 Juvenile arthritis in ulcerative colitis
0.000 0.654 0.345
M09.1 Juvenile arthritis in Crohn's disease [regional enteritis]
0.000 0.654 0.345
M09.0 Juvenile arthritis in psoriasis
0.000 0.654 0.345
G36 Other acute disseminated demyelination
0.345 0.655 0.000
M23.99 Internal derangement of knee, unspecified (Unspecified ligament or Unspecified meniscus)
0.000 0.655 0.345
M23.69 Other spontaneous disruption of ligament(s) of knee (Unspecified ligament or Unspecified meniscus)
0.000 0.657 0.343
M23.67 Other spontaneous disruption of ligament(s) of knee (Capsular ligament)
0.000 0.657 0.343
M23.66 Other spontaneous disruption of ligament(s) of knee-O/unsp
0.000 0.657 0.343
M23.65 Other spontaneous disruption of ligament(s) of knee-Pst hrn
0.000 0.657 0.343
M23.64 Other spontaneous disruption of ligament(s) of knee (Lateral collateral ligament or Anterior horn of lateral meniscus)
0.000 0.657 0.343
M23.63 Other spontaneous disruption of ligament(s) of knee (Medial collateral ligament or Other and unspecified medial meniscus)
0.000 0.657 0.343
M23.62 Other spontaneous disruption of ligament(s) of knee (Posterior cruciate ligament or Posterior horn of medial meniscus)
0.000 0.657 0.343
M23.60 Other spontaneous disruption of ligament(s) of knee (Multiple sites)
0.000 0.657 0.343
E51 Thiamine deficiency
0.000 0.658 0.342
M23.57 Chronic instability of knee (Capsular ligament)
0.000 0.659 0.341
M23.56 Chronic instability of knee (Other and unspecified lateral meniscus)
0.000 0.659 0.341
M23.55 Chronic instability of knee (Posterior horn of lateral meniscus)
0.000 0.659 0.341
M23.54 Chronic instability of knee (Lateral collateral ligament or Anterior horn of lateral meniscus)
0.000 0.659 0.341
M23.53 Chronic instability of knee (Medial collateral ligament or Other and unspecified medial meniscus)
0.000 0.659 0.341
M23.52 Chronic instability of knee (Posterior cruciate ligament or Posterior horn of medial meniscus)
0.000 0.659 0.341
M23.50 Chronic instability of knee (Multiple sites)
0.000 0.659 0.341
E11.7 With multiple complications
0.000 0.660 0.340
E11.1 With ketoacidosis
0.000 0.660 0.340
M60-M63 Disorders of muscles
0.000 0.662 0.338
M23.47 Loose body in knee-Capsular lig
0.000 0.662 0.337
M23.45 Loose body in knee-Pst hrn lat men
0.000 0.662 0.337
M23.44 Loose body in knee-Lat lig/ant men
0.000 0.662 0.337
M23.42 Loose body in knee-Pst lig/hrn men
0.000 0.662 0.337
M23.40 Loose body in knee-Mult sites
0.000 0.662 0.337
M83 Adult osteomalacia
0.000 0.663 0.337
M06.48 Inflammatory polyarthropathy (Other)
0.000 0.664 0.335
M06.47 Inflammatory polyarthropathy (Ankle and foot)
0.000 0.664 0.335
M06.46 Inflammatory polyarthropathy (Lower leg)
0.000 0.664 0.335
M06.45 Inflammatory polyarthropathy (Pelvic region and thigh)
0.000 0.664 0.335
M06.44 Inflammatory polyarthropathy (Hand)
0.000 0.664 0.335
M06.43 Inflammatory polyarthropathy (Forearm)
0.000 0.664 0.335
M06.42 Inflammatory polyarthropathy (Upper arm)
0.000 0.664 0.335
M06.41 Inflammatory polyarthropathy (Shoulder region)
0.000 0.664 0.335
M32.90 Systemic lupus erythematosus, unspecified, Multiple sites
0.000 0.665 0.334
M08.9 Juvenile arthritis, unspecified
0.000 0.666 0.334
M08.8 Other juvenile arthritis
0.000 0.666 0.334
M08.4 Pauciarticular juvenile arthritis
0.000 0.666 0.334
M08.3 Juvenile polyarthritis (seronegative)
0.000 0.666 0.334
M08.2 Juvenile arthritis with systemic onset
0.000 0.666 0.334
M08.1 Juvenile ankylosing spondylitis
0.000 0.666 0.334
M23.97 Internal derangement of knee, unspecified (Capsular ligament)
0.000 0.667 0.333
M23.96 Internal derangement of knee, unspecified (Other and unspecified lateral meniscus)
0.000 0.667 0.333
M23.95 Internal derangement of knee, unspecified (Posterior horn of lateral meniscus)
0.000 0.667 0.333
M23.94 Internal derangement of knee, unspecified (Lateral collateral ligament or Anterior horn of lateral meniscus)
0.000 0.667 0.333
M23.92 Internal derangement of knee, unspecified (Posterior cruciate ligament or Posterior horn of medial meniscus)
0.000 0.667 0.333
M23.90 Internal derangement of knee, unspecified (Multiple sites)
0.000 0.667 0.333
M22.4 Chondromalacia patellae
0.000 0.670 0.330
I21.3 Acute transmural myocardial infarction of unspecified site
0.000 0.671 0.329
M05.3 Rheumatoid arthritis with involvement of other organs and systems
0.000 0.673 0.327
M05.1 Rheumatoid lung disease
0.000 0.673 0.327
M05.0 Felty's syndrome
0.000 0.673 0.327
E44.1 Mild protein-energy malnutrition
0.000 0.673 0.326
E44.0 Moderate protein-energy malnutrition
0.000 0.673 0.326
K90.8 Other intestinal malabsorption
0.000 0.677 0.323
M82.8 Osteoporosis in other diseases classified elsewhere
0.000 0.677 0.323
M82.0 Osteoporosis in multiple myelomatosis
0.000 0.677 0.323
M82.3 Osteoporosis in diseases classified elsewhere, Forearm
0.000 0.677 0.323
K90.3 Pancreatic steatorrhoea
0.000 0.678 0.322
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.678 0.322
K90.1 Tropical sprue
0.000 0.678 0.322
M23.07 Cystic meniscus-Capsular lig
0.000 0.678 0.321
M23.05 Cystic meniscus (Posterior horn of lateral meniscus)
0.000 0.678 0.321
M23.01 Cystic meniscus (Anterior cruciate ligament or Anterior horn of medial meniscus)
0.000 0.678 0.321
M23.00 Cystic meniscus (Multiple sites)
0.000 0.678 0.321
M70.6 Trochanteric bursitis
0.000 0.679 0.321
E67.8 Other specified hyperalimentation
0.000 0.679 0.320
E67.3 Hypervitaminosis D
0.000 0.679 0.320
E67.2 Megavitamin-B6 syndrome
0.000 0.679 0.320
E67.1 Hypercarotenaemia
0.000 0.679 0.320
E67.0 Hypervitaminosis A
0.000 0.679 0.320
M80.4 Drug-induced osteoporosis with pathological fracture
0.000 0.680 0.320
M80.3 Postsurgical malabsorption osteoporosis with pathological fracture
0.000 0.680 0.320
M80.2 Osteoporosis of disuse with pathological fracture
0.000 0.680 0.320
E11.2 With renal complications
0.000 0.681 0.319
M08.0 Juvenile rheumatoid arthritis
0.000 0.683 0.317
M06.06 Seronegative rheumatoid arthritis (Lower leg)
0.001 0.683 0.316
M79 Other soft tissue disorders, not elsewhere classified
0.000 0.683 0.317
M05.9 Seropositive rheumatoid arthritis, unspecified
0.000 0.686 0.314
M33.2 Polymyositis
0.000 0.687 0.312
M49.50 Collapsed vertebra in diseases classified elsewhere (Multiple sites in spine)
0.000 0.688 0.312
M23.03 Cystic meniscus (Medial collateral ligament or Other and unspecified medial meniscus)
0.000 0.688 0.312
E11.8 With unspecified complications
0.000 0.688 0.312
I21.0 Acute transmural myocardial infarction of anterior wall
0.000 0.690 0.310
M80.97 Unspecified osteoporosis with pathological fracture (Ankle and foot)
0.000 0.691 0.309
M80.96 Unspecified osteoporosis with pathological fracture (Lower leg)
0.000 0.691 0.309
M80.95 Unspecified osteoporosis with pathological fracture (Pelvic region and thigh)
0.000 0.691 0.309
M80.94 Unspecified osteoporosis with pathological fracture (Hand)
0.000 0.691 0.309
M80.93 Unspecified osteoporosis with pathological fracture (Forearm)
0.000 0.691 0.309
M80.92 Unspecified osteoporosis with pathological fracture (Upper arm)
0.000 0.691 0.309
M80.91 Unspecified osteoporosis with pathological fracture (Shoulder region)
0.000 0.691 0.309
M23.91 Internal derangement of knee, unspecified (Anterior cruciate ligament or Anterior horn of medial meniscus)
0.000 0.691 0.309
M25 Other joint disorders, not elsewhere classified
0.000 0.692 0.308
M80.99 Unspecified osteoporosis with pathological fracture (Site unspecified)
0.000 0.692 0.307
M82.19 Osteoporosis in endocrine disorders (Site unspecified)
0.000 0.693 0.307
M82.18 Osteoporosis in endocrine disorders (Other)
0.000 0.693 0.307
M82.17 Osteoporosis in endocrine disorders (Ankle and foot)
0.000 0.693 0.307
M82.16 Osteoporosis in endocrine disorders (Lower leg)
0.000 0.693 0.307
M82.15 Osteoporosis in endocrine disorders (Pelvic region and thigh)
0.000 0.693 0.307
M82.14 Osteoporosis in endocrine disorders (Hand)
0.000 0.693 0.307
M82.13 Osteoporosis in endocrine disorders (Forearm)
0.000 0.693 0.307
M82.12 Osteoporosis in endocrine disorders (Upper arm)
0.000 0.693 0.307
M49.54 Collapsed vertebra in diseases classified elsewhere (Thoracic region)
0.000 0.693 0.307
M80.10 Postoophorectomy osteoporosis with pathological fracture (Multiple sites)
0.000 0.693 0.307
M23.02 Cystic meniscus (Posterior cruciate ligament or Posterior horn of medial meniscus)
0.000 0.696 0.304
M23.19 Discoid meniscus (congenital) (Unspecified ligament or Unspecified meniscus)
0.000 0.698 0.301
M23.17 Discoid meniscus (congenital)-Capsular lig
0.000 0.698 0.301
M23.15 Discoid meniscus (congenital) (Posterior horn of lateral meniscus)
0.000 0.698 0.301
M23.14 Discoid meniscus (congenital) (Lateral collateral ligament or Anterior horn of lateral meniscus)
0.000 0.698 0.301
M23.13 Discoid meniscus (congenital) (Medial collateral ligament or Other and unspecified medial meniscus)
0.000 0.698 0.301
M23.12 Discoid meniscus (congenital) (Posterior cruciate ligament or Posterior horn of medial meniscus)
0.000 0.698 0.301
M23.11 Discoid meniscus (congenital) (Anterior cruciate ligament or Anterior horn of medial meniscus)
0.000 0.698 0.301
M23.10 Discoid meniscus (congenital) (Multiple sites)
0.000 0.698 0.301
E58 Dietary calcium deficiency
0.000 0.699 0.301
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.699 0.301
E63 Other nutritional deficiencies
0.000 0.699 0.301
E50 Vitamin A deficiency
0.000 0.699 0.301
E60 Dietary zinc deficiency
0.000 0.699 0.301
E59 Dietary selenium deficiency
0.000 0.699 0.301
E52 Niacin deficiency [pellagra]
0.000 0.699 0.301
E11.3 With ophthalmic complications
0.000 0.701 0.299
E56 Other vitamin deficiencies
0.000 0.701 0.298
M80.0 Postmenopausal osteoporosis with pathological fracture
0.000 0.703 0.297
M79.9 Soft tissue disorder, unspecified
0.000 0.704 0.296
M76 Enthesopathies of lower limb, excluding foot
0.000 0.708 0.292
M73 Soft tissue disorders in diseases classified elsewhere
0.000 0.709 0.291
M80.8 Other osteoporosis with pathological fracture
0.000 0.709 0.291
M25.4 Effusion of joint
0.000 0.709 0.291
M11.1 Familial chondrocalcinosis
0.000 0.710 0.290
M11.0 Hydroxyapatite deposition disease
0.000 0.710 0.290
M79.1 Myalgia
0.000 0.710 0.290
M12.8 Other specific arthropathies, not elsewhere classified
0.000 0.710 0.289
M12.5 Traumatic arthropathy
0.000 0.710 0.289
M12.4 Intermittent hydrarthrosis
0.000 0.710 0.289
M12.1 Kaschin-Beck disease
0.000 0.710 0.289
M12.0 Chronic postrheumatic arthropathy [Jaccoud]
0.000 0.710 0.289
M23.61 Other spontaneous disruption of ligament(s) of knee (Anterior cruciate ligament or Anterior horn of medial meniscus)
0.000 0.710 0.289
E61 Deficiency of other nutrient elements
0.000 0.713 0.287

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

This website was created, designed, and edited by ORCID iD iconPatrick K. Albers

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