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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs2844505
log Bayes Factor = 77.5322
Chromosome 6   position 31,439,063  (GRCh37) Explore rs2844505 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E03.9 Hypothyroidism, unspecified
0.000 0.000 1.000
E10.9 Without complications
0.000 0.000 1.000
K90.0 Coeliac disease
0.000 0.000 1.000
M45.X9 Ankylosing spondylitis (Site unspecified)
1.000 0.000 0.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
E10-E14 Diabetes mellitus
0.000 0.000 1.000
E00-E07 Disorders of thyroid gland
0.000 0.000 1.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.000 1.000
E03 Other hypothyroidism
0.000 0.000 1.000
E78.0 Pure hypercholesterolaemia
0.000 0.000 1.000
G35 Multiple sclerosis
1.000 0.000 0.000
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.000 0.000 1.000
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.001 0.999
E10.3 With ophthalmic complications
0.000 0.001 0.999
E05.9 Thyrotoxicosis, unspecified
0.000 0.001 0.999
E14 Unspecified diabetes mellitus
0.000 0.002 0.998
E11 Non-insulin-dependent diabetes mellitus
0.000 0.002 0.998
E11.9 Without complications
0.000 0.003 0.997
E10.1 With ketoacidosis
0.000 0.003 0.997
E70-E90 Metabolic disorders
0.000 0.005 0.995
E07 Other disorders of thyroid
0.000 0.010 0.990
E78.2 Mixed hyperlipidaemia
0.000 0.014 0.986
E14.9 Without complications
0.000 0.016 0.984
M45 Ankylosing spondylitis
0.982 0.018 0.000
E07.9 Disorder of thyroid, unspecified
0.000 0.019 0.981
E10.4 With neurological complications
0.000 0.021 0.979
M45.X0 Ankylosing spondylitis (Multiple sites in spine)
0.976 0.024 0.000
E10.2 With renal complications
0.000 0.058 0.942
E14.3 With ophthalmic complications
0.000 0.066 0.934
E83.1 Disorders of iron metabolism
0.930 0.070 0.000
E78.8 Other disorders of lipoprotein metabolism
0.000 0.081 0.919
I83.9 Varicose veins of lower extremities without ulcer or inflammation
0.882 0.118 0.000
I83 Varicose veins of lower extremities
0.876 0.124 0.000
I83.0 Varicose veins of lower extremities with ulcer
0.874 0.126 0.000
E13 Other specified diabetes mellitus
0.000 0.134 0.866
G35-G37 Demyelinating diseases of the central nervous system
0.859 0.141 0.000
E11.5 With peripheral circulatory complications
0.000 0.142 0.858
E10.0 With coma
0.000 0.145 0.855
E78.4 Other hyperlipidaemia
0.000 0.146 0.854
H20.9 Iridocyclitis, unspecified
0.846 0.154 0.000
E10.8 With unspecified complications
0.000 0.155 0.845
G37 Other demyelinating diseases of central nervous system
0.828 0.172 0.000
E10.6 With other specified complications
0.000 0.178 0.822
E14.4 With neurological complications
0.000 0.189 0.811
E40-E46 Malnutrition
0.000 0.199 0.801
E13.9 Without complications
0.000 0.210 0.790
E74 Other disorders of carbohydrate metabolism
0.000 0.210 0.789
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.213 0.787
E14.1 With ketoacidosis
0.000 0.214 0.786
E78.6 Lipoprotein deficiency
0.000 0.214 0.786
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.000 0.217 0.783
M45.X2 Ankylosing spondylitis (Cervical region)
0.777 0.222 0.000
E14.5 With peripheral circulatory complications
0.000 0.227 0.773
E14.8 With unspecified complications
0.000 0.228 0.772
E07.8 Other specified disorders of thyroid
0.000 0.235 0.765
K90 Intestinal malabsorption
0.000 0.236 0.764
E88 Other metabolic disorders
0.000 0.242 0.758
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.247 0.753
E11.6 With other specified complications
0.000 0.249 0.750
E79 Disorders of purine and pyrimidine metabolism
0.000 0.255 0.745
E11.2 With renal complications
0.000 0.255 0.745
G37.8 Other specified demyelinating diseases of central nervous system
0.740 0.260 0.000
E11.0 With coma
0.000 0.265 0.735
E05.8 Other thyrotoxicosis
0.000 0.266 0.734
M45.X6 Ankylosing spondylitis (Lumbar region)
0.733 0.267 0.000
E11.1 With ketoacidosis
0.000 0.273 0.727
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.279 0.721
I83.1 Varicose veins of lower extremities with inflammation
0.719 0.281 0.000
E10.7 With multiple complications
0.000 0.283 0.717
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.283 0.717
E00 Congenital iodine-deficiency syndrome
0.000 0.283 0.717
E12 Malnutrition-related diabetes mellitus
0.000 0.283 0.717
E03.5 Myxoedema coma
0.000 0.283 0.717
E03.4 Atrophy of thyroid (acquired)
0.000 0.283 0.717
E03.3 Postinfectious hypothyroidism
0.000 0.283 0.717
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.283 0.717
E78.3 Hyperchylomicronaemia
0.000 0.283 0.717
E05.5 Thyroid crisis or storm
0.000 0.283 0.717
E05.4 Thyrotoxicosis factitia
0.000 0.283 0.717
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.283 0.717
E14.7 With multiple complications
0.000 0.284 0.716
E14.2 Withrenal complications
0.000 0.284 0.716
E14.0 With coma
0.000 0.284 0.716
E11.7 With multiple complications
0.000 0.284 0.715
E77 Disorders of glycoprotein metabolism
0.000 0.287 0.713
E76 Disorders of glycosaminoglycan metabolism
0.000 0.287 0.713
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.000 0.287 0.713
E70 Disorders of aromatic amino-acid metabolism
0.000 0.287 0.713
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.000 0.287 0.713
G37.3 Acute transverse myelitis in demyelinating disease of central nervous system
0.712 0.288 0.000
E07.1 Dyshormogenetic goitre
0.000 0.290 0.710
E07.0 Hypersecretion of calcitonin
0.000 0.290 0.710
G37.9 Demyelinating disease of central nervous system, unspecified
0.709 0.291 0.000
M45.X8 Ankylosing spondylitis (Sacral and sacrococcygeal region)
0.704 0.296 0.000
M45.X7 Ankylosing spondylitis (Lumbosacral region)
0.704 0.296 0.000
M45.X5 Ankylosing spondylitis (Thoracolumbar region)
0.704 0.296 0.000
M45.X4 Ankylosing spondylitis (Thoracic region)
0.704 0.296 0.000
M45.X3 Ankylosing spondylitis (Cervicothoracic region)
0.704 0.296 0.000
M45.X1 Ankylosing spondylitis (Occipito-atlanto-axial region)
0.704 0.296 0.000
H20 Iridocyclitis
0.701 0.299 0.000
K90.9 Intestinal malabsorption, unspecified
0.000 0.309 0.691
I83.2 Varicose veins of lower extremities with both ulcer and inflammation
0.689 0.311 0.000
E73 Lactose intolerance
0.000 0.312 0.688
E89.6 Postprocedural adrenocortical(-medullary) hypofunction
0.000 0.316 0.684
E72 Other disorders of amino-acid metabolism
0.000 0.316 0.683
E74.3 Other disorders of intestinal carbohydrate absorption
0.000 0.318 0.682
E10.5 With peripheral circulatory complications
0.000 0.327 0.673
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.330 0.670
E03.8 Other specified hypothyroidism
0.000 0.338 0.662
E46 Unspecified protein-energy malnutrition
0.000 0.342 0.658
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.342 0.658
E84 Cystic fibrosis
0.000 0.344 0.656
H20.1 Chronic iridocyclitis
0.655 0.345 0.000
E78.5 Hyperlipidaemia, unspecified
0.000 0.350 0.650
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.000 0.354 0.645
E89.2 Postprocedural hypoparathyroidism
0.000 0.357 0.643
E03.1 Congenital hypothyroidism without goitre
0.000 0.357 0.642
E88.2 Lipomatosis, not elsewhere classified
0.000 0.359 0.641
G36 Other acute disseminated demyelination
0.635 0.365 0.000
E83 Disorders of mineral metabolism
0.559 0.379 0.062
E13.8 With unspecified complications
0.000 0.379 0.621
E13.7 With multiple complications
0.000 0.379 0.621
E13.6 With other specified complications
0.000 0.379 0.621
E13.5 With peripheral circulatory complications
0.000 0.379 0.621
E13.4 With neurological complications
0.000 0.379 0.621
E13.2 With renal complications
0.000 0.379 0.621
E13.1 With ketoacidosis
0.000 0.379 0.621
E13.0 With coma
0.000 0.379 0.621
E14.6 With other specified complications
0.000 0.386 0.614
E06 Thyroiditis
0.000 0.389 0.611
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.000 0.399 0.601
H20.0 Acute and subacute iridocyclitis
0.598 0.402 0.000
G37.5 Concentric sclerosis [Balo]
0.594 0.406 0.000
G37.4 Subacute necrotising myelitis
0.594 0.406 0.000
G37.2 Central pontine myelinolysis
0.594 0.406 0.000
G37.1 Central demyelination of corpus callosum
0.594 0.406 0.000
G37.0 Diffuse sclerosis
0.594 0.406 0.000
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.417 0.582
E89.3 Postprocedural hypopituitarism
0.000 0.421 0.579
E88.8 Other specified metabolic disorders
0.000 0.423 0.577
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.426 0.574
E45 Retarded development following protein-energy malnutrition
0.000 0.426 0.574
E43 Unspecified severe protein-energy malnutrition
0.000 0.426 0.574
E42 Marasmic kwashiorkor
0.000 0.426 0.574
E41 Nutritional marasmus
0.000 0.426 0.574
E40 Kwashiorkor
0.000 0.426 0.574
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
0.000 0.434 0.566
E74.9 Disorder of carbohydrate metabolism, unspecified
0.000 0.434 0.566
E74.8 Other specified disorders of carbohydrate metabolism
0.000 0.434 0.566
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
0.000 0.434 0.566
E74.2 Disorders of galactose metabolism
0.000 0.434 0.566
E74.1 Disorders of fructose metabolism
0.000 0.434 0.566
E78.1 Pure hyperglyceridaemia
0.000 0.438 0.562
E89.9 Postprocedural endocrine and metabolic disorder, unspecified
0.000 0.438 0.562
E89.8 Other postprocedural endocrine and metabolic disorders
0.000 0.438 0.562
E89.5 Postprocedural testicular hypofunction
0.000 0.438 0.562
E89.1 Postprocedural hypoinsulinaemia
0.000 0.438 0.562
K90.8 Other intestinal malabsorption
0.000 0.439 0.561
E13.3 With ophthalmic complications
0.000 0.443 0.557
E11.4 With neurological complications
0.000 0.451 0.549
K90.3 Pancreatic steatorrhoea
0.000 0.452 0.548
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.452 0.548
K90.1 Tropical sprue
0.000 0.452 0.548
E88.9 Metabolic disorder, unspecified
0.000 0.456 0.544
E89.4 Postprocedural ovarian failure
0.000 0.461 0.539
E88.0 Disorders of plasma-protein metabolism, not elsewhere classified
0.000 0.463 0.536
E83.3 Disorders of phosphorus metabolism
0.523 0.465 0.012
E79.9 Disorder of purine and pyrimidine metabolism, unspecified
0.000 0.465 0.534
E79.8 Other disorders of purine and pyrimidine metabolism
0.000 0.465 0.534
E79.1 Lesch-Nyhan syndrome
0.000 0.465 0.534
E16 Other disorders of pancreatic internal secretion
0.000 0.479 0.521
E15 Nondiabetic hypoglycaemic coma
0.000 0.483 0.517
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.000 0.486 0.514
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.000 0.486 0.514
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.000 0.486 0.514
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.000 0.486 0.514
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.486 0.514
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.000 0.486 0.514
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.000 0.486 0.514
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.000 0.486 0.514
E12.9 Without complications
0.000 0.486 0.514
E12.8 With unspecified complications
0.000 0.486 0.514
E12.7 With multiple complications
0.000 0.486 0.514
E12.6 With other specified complications
0.000 0.486 0.514
E12.5 With peripheral circulatory complications
0.000 0.486 0.514
E12.4 With neurological complications
0.000 0.486 0.514
E12.3 With ophthalmic complications
0.000 0.486 0.514
E12.2 With renal complications
0.000 0.486 0.514
E12.1 With ketoacidosis
0.000 0.486 0.514
E12.0 With coma
0.000 0.486 0.514
E70.9 Disorder of aromatic amino-acid metabolism, unspecified
0.000 0.488 0.511
E70.8 Other disorders of aromatic amino-acid metabolism
0.000 0.488 0.511
E70.3 Albinism
0.000 0.488 0.511
E70.2 Disorders of tyrosine metabolism
0.000 0.488 0.511
E70.1 Other hyperphenylalaninaemias
0.000 0.488 0.511
E70.0 Classical phenylketonuria
0.000 0.488 0.511
E71.3 Disorders of fatty-acid metabolism
0.000 0.488 0.511
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified
0.000 0.488 0.511
E71.1 Other disorders of branched-chain amino-acid metabolism
0.000 0.488 0.511
E71.0 Maple-syrup-urine disease
0.000 0.488 0.511
E76.9 Disorder of glucosaminoglycan metabolism, unspecified
0.000 0.488 0.511
E76.8 Other disorders of glucosaminoglycan metabolism
0.000 0.488 0.511
E76.3 Mucopolysaccharidosis, unspecified
0.000 0.488 0.511
E76.2 Other mucopolysaccharidoses
0.000 0.488 0.511
E76.1 Mucopolysaccharidosis, type II
0.000 0.488 0.511
E76.0 Mucopolysaccharidosis, type I
0.000 0.488 0.511
E77.9 Disorder of glycoprotein metabolism, unspecified
0.000 0.488 0.511
E77.8 Other disorders of glycoprotein metabolism
0.000 0.488 0.511
E77.1 Defects in glycoprotein degradation
0.000 0.488 0.511
E77.0 Defects in posttranslational modification of lysosomal enzymes
0.000 0.488 0.511
E50-E64 Other nutritional deficiencies
0.000 0.489 0.511
H20.2 Lens-induced iridocyclitis
0.502 0.497 0.000
E11.3 With ophthalmic complications
0.000 0.503 0.497
E73.8 Other lactose intolerance
0.000 0.507 0.493
E73.1 Secondary lactase deficiency
0.000 0.507 0.493
E73.0 Congenital lactase deficiency
0.000 0.507 0.493
E72.9 Disorder of amino-acid metabolism, unspecified
0.000 0.510 0.490
E72.8 Other specified disorders of amino-acid metabolism
0.000 0.510 0.490
E72.5 Disorders of glycine metabolism
0.000 0.510 0.490
E72.4 Disorders of ornithine metabolism
0.000 0.510 0.490
E72.3 Disorders of lysine and hydroxylysine metabolism
0.000 0.510 0.490
E72.2 Disorders of urea cycle metabolism
0.000 0.510 0.490
E72.1 Disorders of sulphur-bearing amino-acid metabolism
0.000 0.510 0.490
E88.1 Lipodystrophy, not elsewhere classified
0.000 0.511 0.488
E74.0 Glycogen storage disease
0.000 0.516 0.483
E80 Disorders of porphyrin and bilirubin metabolism
0.001 0.519 0.480
E88.3 Tumour lysis syndrome
0.000 0.524 0.475
G36.0 Neuromyelitis optica [Devic]
0.474 0.526 0.000
E84.8 Cystic fibrosis with other manifestations
0.000 0.530 0.470
E84.1 Cystic fibrosis with intestinal manifestations
0.000 0.530 0.470
E84.0 Cystic fibrosis with pulmonary manifestations
0.000 0.530 0.470
E73.9 Lactose intolerance, unspecified
0.000 0.532 0.468
E75.6 Lipid storage disorder, unspecified
0.000 0.537 0.463
E75.4 Neuronal ceroid lipofuscinosis
0.000 0.537 0.463
E75.3 Sphingolipidosis, unspecified
0.000 0.537 0.463
E75.2 Other sphingolipidosis
0.000 0.537 0.463
E75.1 Other gangliosidosis
0.000 0.537 0.463
E75.0 GM2 gangliosidosis
0.000 0.537 0.463
E72.0 Disorders of amino-acid transport
0.000 0.540 0.460
E11.8 With unspecified complications
0.001 0.543 0.456
G36.9 Acute disseminated demyelination, unspecified
0.455 0.545 0.000
G36.8 Other specified acute disseminated demyelination
0.455 0.545 0.000
G36.1 Acute and subacute haemorrhagic leukoencephalitis [Hurst]
0.455 0.545 0.000
E61 Deficiency of other nutrient elements
0.000 0.550 0.449
E83.9 Disorder of mineral metabolism, unspecified
0.401 0.555 0.044
E83.8 Other disorders of mineral metabolism
0.401 0.555 0.044
E83.2 Disorders of zinc metabolism
0.401 0.555 0.044
E83.0 Disorders of copper metabolism
0.401 0.555 0.044
E06.5 Other chronic thyroiditis
0.000 0.562 0.438
E06.4 Drug-induced thyroiditis
0.000 0.562 0.438
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.562 0.438
E06.1 Subacute thyroiditis
0.000 0.562 0.438
E06.0 Acute thyroiditis
0.000 0.562 0.438
E16.1 Other hypoglycaemia
0.000 0.571 0.429
E20-E35 Disorders of other endocrine glands
0.000 0.581 0.419
E84.9 Cystic fibrosis, unspecified
0.000 0.587 0.412
E44.1 Mild protein-energy malnutrition
0.000 0.588 0.412
E44.0 Moderate protein-energy malnutrition
0.000 0.588 0.412
E85 Amyloidosis
0.001 0.588 0.411
E06.3 Autoimmune thyroiditis
0.000 0.590 0.410
E61.1 Iron deficiency
0.000 0.600 0.400
E78.9 Disorder of lipoprotein metabolism, unspecified
0.000 0.605 0.395
E75.5 Other lipid storage disorders
0.001 0.605 0.395
M75.0 Adhesive capsulitis of shoulder
0.000 0.618 0.382
E51 Thiamine deficiency
0.000 0.622 0.378
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.624 0.376
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.626 0.374
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.626 0.374
E16.4 Abnormal secretion of gastrin
0.000 0.626 0.374
E16.3 Increased secretion of glucagon
0.000 0.626 0.374
E80.2 Other porphyria
0.001 0.628 0.371
E06.9 Thyroiditis, unspecified
0.000 0.629 0.370
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.633 0.366
E63 Other nutritional deficiencies
0.000 0.633 0.366
E50 Vitamin A deficiency
0.000 0.633 0.366
E60 Dietary zinc deficiency
0.000 0.633 0.366
E59 Dietary selenium deficiency
0.000 0.633 0.366
E54 Ascorbic acid deficiency
0.000 0.633 0.366
E52 Niacin deficiency [pellagra]
0.000 0.633 0.366
E80.7 Disorder of bilirubin metabolism, unspecified
0.001 0.655 0.344
E80.5 Crigler-Najjar syndrome
0.001 0.655 0.344
E80.3 Defects of catalase and peroxydase
0.001 0.655 0.344
E80.1 Porphyria cutanea tarda
0.001 0.655 0.344
E80.0 Hereditary erythropoietic porphyria
0.001 0.655 0.344
E65-E68 Obesity and other hyperalimentation
0.000 0.656 0.344
E56 Other vitamin deficiencies
0.000 0.658 0.341
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.000 0.661 0.339
E61.2 Magnesium deficiency
0.000 0.663 0.336
E80.6 Other disorders of bilirubin metabolism
0.001 0.668 0.331
E61.9 Deficiency of nutrient element, unspecified
0.000 0.677 0.322
E61.8 Deficiency of other specified nutrient elements
0.000 0.677 0.322
E61.7 Deficiency of multiple nutrient elements
0.000 0.677 0.322
E61.6 Vanadium deficiency
0.000 0.677 0.322
E61.5 Molybdenum deficiency
0.000 0.677 0.322
E61.4 Chromium deficiency
0.000 0.677 0.322
E61.3 Manganese deficiency
0.000 0.677 0.322
E61.0 Copper deficiency
0.000 0.677 0.322
E22 Hyperfunction of pituitary gland
0.000 0.680 0.320
E25 Adrenogenital disorders
0.000 0.687 0.313
E58 Dietary calcium deficiency
0.000 0.687 0.313
C18.7 Sigmoid colon
0.000 0.690 0.310
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.700 0.300
E32 Diseases of thymus
0.000 0.700 0.300
E31 Polyglandular dysfunction
0.000 0.700 0.300
E30 Disorders of puberty, not elsewhere classified
0.000 0.700 0.300
H20.8 Other iridocyclitis
0.295 0.705 0.001
E85.8 Other amyloidosis
0.001 0.705 0.295
E85.2 Heredofamilial amyloidosis, unspecified
0.001 0.705 0.295
E85.1 Neuropathic heredofamilial amyloidosis
0.001 0.705 0.295
E85.0 Nonneuropathic heredofamilial amyloidosis
0.001 0.705 0.295
E24 Cushing's syndrome
0.000 0.710 0.290
E16.2 Hypoglycaemia, unspecified
0.000 0.711 0.289
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.000 0.716 0.284
E29 Testicular dysfunction
0.000 0.716 0.283
E51.2 Wernicke's encephalopathy
0.000 0.718 0.282
E20 Hypoparathyroidism
0.000 0.718 0.282
E23 Hypofunction and other disorders of pituitary gland
0.000 0.720 0.280
H15-H22 Disorders of sclera, cornea, iris and ciliary body
0.276 0.723 0.000
E21.3 Hyperparathyroidism, unspecified
0.000 0.728 0.272
E51.9 Thiamine deficiency, unspecified
0.000 0.729 0.271
E51.8 Other manifestations of thiamine deficiency
0.000 0.729 0.271
E51.1 Beriberi
0.000 0.729 0.271
E85.9 Amyloidosis, unspecified
0.001 0.733 0.267
E26 Hyperaldosteronism
0.000 0.733 0.267
E27 Other disorders of adrenal gland
0.000 0.734 0.266
H16 Keratitis
0.264 0.736 0.000
E50.9 Vitamin A deficiency, unspecified
0.000 0.737 0.263
E50.8 Other manifestations of vitamin A deficiency
0.000 0.737 0.263
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.737 0.263
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.737 0.263
E50.5 Vitamin A deficiency with night blindness
0.000 0.737 0.263
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.737 0.263
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.737 0.263
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.737 0.263
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.737 0.263
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.737 0.263
E63.9 Nutritional deficiency, unspecified
0.000 0.737 0.263
E63.8 Other specified nutritional deficiencies
0.000 0.737 0.263
E63.1 Imbalance of constituents of food intake
0.000 0.737 0.263
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.737 0.263
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.737 0.263
E64.8 Sequelae of other nutritional deficiencies
0.000 0.737 0.263
E64.3 Sequelae of rickets
0.000 0.737 0.263
E64.2 Sequelae of vitamin C deficiency
0.000 0.737 0.263
E64.1 Sequelae of vitamin A deficiency
0.000 0.737 0.263
E64.0 Sequelae of protein-energy malnutrition
0.000 0.737 0.263
E89.0 Postprocedural hypothyroidism
0.000 0.742 0.258
E22.0 Acromegaly and pituitary gigantism
0.000 0.744 0.256
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.000 0.744 0.256
H16.0 Corneal ulcer
0.256 0.744 0.000
E67 Other hyperalimentation
0.000 0.753 0.247
E68 Sequelae of hyperalimentation
0.000 0.753 0.247
E56.9 Vitamin deficiency, unspecified
0.000 0.755 0.245
E56.8 Deficiency of other vitamins
0.000 0.755 0.245
E56.0 Deficiency of vitamin E
0.000 0.755 0.245
E55 Vitamin D deficiency
0.000 0.755 0.244
E28 Ovarian dysfunction
0.000 0.756 0.244
E21.5 Disorder of parathyroid gland, unspecified
0.000 0.757 0.243
E21.4 Other specified disorders of parathyroid gland
0.000 0.757 0.243
E85.3 Secondary systemic amyloidosis
0.001 0.760 0.239
E27.9 Disorder of adrenal gland, unspecified
0.000 0.761 0.239
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.000 0.762 0.238
E23.7 Disorder of pituitary gland, unspecified
0.000 0.766 0.234
E21.2 Other hyperparathyroidism
0.000 0.766 0.234
E83.4 Disorders of magnesium metabolism
0.199 0.769 0.033
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.770 0.229
E22.8 Other hyperfunction of pituitary gland
0.000 0.770 0.229
E25.9 Adrenogenital disorder, unspecified
0.000 0.775 0.225
E25.8 Other adrenogenital disorders
0.000 0.775 0.225
E27.3 Drug-induced adrenocortical insufficiency
0.000 0.775 0.224
E24.2 Drug-induced Cushing's syndrome
0.000 0.779 0.221
E56.1 Deficiency of vitamin K
0.000 0.780 0.220
H16.8 Other keratitis
0.219 0.781 0.000
E23.6 Other disorders of pituitary gland
0.000 0.783 0.217
E34 Other endocrine disorders
0.000 0.783 0.217
E30.9 Disorder of puberty, unspecified
0.000 0.784 0.215
E30.8 Other disorders of puberty
0.000 0.784 0.215
E30.1 Precocious puberty
0.000 0.784 0.215
E30.0 Delayed puberty
0.000 0.784 0.215
E31.9 Polyglandular dysfunction, unspecified
0.000 0.784 0.215
E31.8 Other polyglandular dysfunction
0.000 0.784 0.215
E31.1 Polyglandular hyperfunction
0.000 0.784 0.215
E31.0 Autoimmune polyglandular failure
0.000 0.784 0.215
E32.9 Disease of thymus, unspecified
0.000 0.784 0.215
E32.8 Other diseases of thymus
0.000 0.784 0.215
E32.1 Abscess of thymus
0.000 0.784 0.215
E32.0 Persistent hyperplasia of thymus
0.000 0.784 0.215
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.784 0.215
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.784 0.215
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.784 0.215
E53 Deficiency of other B group vitamins
0.000 0.788 0.212
H22 Disorders of iris and ciliary body in diseases classified elsewhere
0.211 0.789 0.000
E21.0 Primary hyperparathyroidism
0.000 0.789 0.211
E24.8 Other Cushing's syndrome
0.000 0.792 0.208
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.000 0.792 0.208
E24.3 Ectopic ACTH syndrome
0.000 0.792 0.208
E24.1 Nelson's syndrome
0.000 0.792 0.208
E23.2 Diabetes insipidus
0.000 0.793 0.207
E24.0 Pituitary-dependent Cushing's disease
0.000 0.796 0.204
E29.9 Testicular dysfunction, unspecified
0.000 0.796 0.203
E29.8 Other testicular dysfunction
0.000 0.796 0.203
E29.0 Testicular hyperfunction
0.000 0.796 0.203
E20.8 Other hypoparathyroidism
0.000 0.797 0.202
E20.1 Pseudohypoparathyroidism
0.000 0.797 0.202
E20.0 Idiopathic hypoparathyroidism
0.000 0.797 0.202
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.000 0.799 0.201
E23.1 Drug-induced hypopituitarism
0.000 0.799 0.201
E26.9 Hyperaldosteronism, unspecified
0.000 0.808 0.191
E26.8 Other hyperaldosteronism
0.000 0.808 0.191
E26.1 Secondary hyperaldosteronism
0.000 0.808 0.191
E27.5 Adrenomedullary hyperfunction
0.000 0.809 0.191
E27.0 Other adrenocortical overactivity
0.000 0.809 0.191
H16.4 Corneal neovascularisation
0.189 0.811 0.000
E29.1 Testicular hypofunction
0.000 0.813 0.186
H16.3 Interstitial and deep keratitis
0.186 0.814 0.000
H16.1 Other superficial keratitis without conjunctivitis
0.186 0.814 0.000
H19 Disorders of sclera and cornea in diseases classified elsewhere
0.185 0.815 0.000
E24.9 Cushing's syndrome, unspecified
0.000 0.815 0.185
E20.9 Hypoparathyroidism, unspecified
0.000 0.816 0.184
H17 Corneal scars and opacities
0.184 0.816 0.000
E85.4 Organ-limited amyloidosis
0.001 0.817 0.182
E27.8 Other specified disorders of adrenal gland
0.000 0.818 0.182
E65 Localised adiposity
0.000 0.820 0.179
E22.1 Hyperprolactinaemia
0.000 0.821 0.179
H16.2 Keratoconjunctivitis
0.179 0.821 0.000
E67.8 Other specified hyperalimentation
0.000 0.823 0.177
E67.3 Hypervitaminosis D
0.000 0.823 0.177
E67.2 Megavitamin-B6 syndrome
0.000 0.823 0.177
E67.1 Hypercarotenaemia
0.000 0.823 0.177
E67.0 Hypervitaminosis A
0.000 0.823 0.177
E55.0 Rickets, active
0.000 0.824 0.175
E28.9 Ovarian dysfunction, unspecified
0.000 0.825 0.175
E28.8 Other ovarian dysfunction
0.000 0.825 0.175
E28.1 Androgen excess
0.000 0.825 0.175
E28.0 Oestrogen excess
0.000 0.825 0.175
H22.1 Iridocyclitis in other diseases classified elsewhere
0.164 0.836 0.000
E28.3 Primary ovarian failure
0.000 0.841 0.159
E26.0 Primary hyperaldosteronism
0.000 0.842 0.158
E34.5 Androgen resistance syndrome
0.000 0.844 0.155
E34.4 Constitutional tall stature
0.000 0.844 0.155
E34.3 Short stature, not elsewhere classified
0.000 0.844 0.155
E34.2 Ectopic hormone secretion, not elsewhere classified
0.000 0.844 0.155
E34.1 Other hypersecretion of intestinal hormones
0.000 0.844 0.155
H16.9 Keratitis, unspecified
0.155 0.845 0.000
E83.5 Disorders of calcium metabolism
0.142 0.847 0.012
E53.1 Pyridoxine deficiency
0.000 0.848 0.152
E53.0 Riboflavin deficiency
0.000 0.848 0.152
H22.8 Other disorders of iris and ciliary body in diseases classified elsewhere
0.151 0.848 0.000
H22.0 Iridocyclitis in infectious and parasitic diseases classified elsewhere
0.151 0.848 0.000
H15 Disorders of sclera
0.151 0.849 0.000
E34.8 Other specified endocrine disorders
0.000 0.850 0.150
E53.9 Vitamin B deficiency, unspecified
0.000 0.857 0.143
E28.2 Polycystic ovarian syndrome
0.000 0.858 0.142
H17.8 Other corneal scars and opacities
0.139 0.861 0.000
E27.4 Other and unspecified adrenocortical insufficiency
0.000 0.863 0.137
H18 Other disorders of cornea
0.136 0.864 0.000
E34.9 Endocrine disorder, unspecified
0.000 0.865 0.134
H19.2 Keratitis and keratoconjunctivitis in other infectious and parasitic diseases classified elsewhere
0.134 0.866 0.000
H19.8 Other disorders of sclera and cornea in diseases classified elsewhere
0.133 0.867 0.000
H19.0 Scleritis and episcleritis in diseases classified elsewhere
0.133 0.867 0.000
H19.3 Keratitis and keratoconjunctivitis in other diseases classified elsewhere
0.132 0.868 0.000
H17.1 Other central corneal opacity
0.132 0.868 0.000
H17.0 Adherent leukoma
0.132 0.868 0.000
H21 Other disorders of iris and ciliary body
0.131 0.869 0.000
E27.1 Primary adrenocortical insufficiency
0.000 0.873 0.127
G56.0 Carpal tunnel syndrome
0.000 0.874 0.126
H19.1 Herpesviral keratitis and keratoconjunctivitis
0.119 0.880 0.000
M45-M49 Spondylopathies
0.119 0.881 0.000
E34.0 Carcinoid syndrome
0.000 0.882 0.118
H18.1 Bullous keratopathy
0.115 0.885 0.000
H18.3 Changes in corneal membranes
0.115 0.885 0.000
H18.6 Keratoconus
0.114 0.886 0.000
H15.9 Disorder of sclera, unspecified
0.108 0.891 0.000
E27.2 Addisonian crisis
0.001 0.892 0.107
H17.9 Corneal scar and opacity, unspecified
0.107 0.893 0.000
H15.8 Other disorders of sclera
0.098 0.901 0.000
H15.1 Episcleritis
0.098 0.901 0.000
H18.7 Other corneal deformities
0.097 0.903 0.000
M48 Other spondylopathies
0.095 0.905 0.000
H21.4 Pupillary membranes
0.094 0.905 0.000
H21.5 Other adhesions and disruptions of iris and ciliary body
0.094 0.906 0.000
H21.3 Cyst of iris, ciliary body and anterior chamber
0.094 0.906 0.000
H15.0 Scleritis
0.092 0.908 0.000
H21.8 Other specified disorders of iris and ciliary body
0.091 0.909 0.000
M48.5 Collapsed vertebra, not elsewhere classified
0.091 0.909 0.000
H21.0 Hyphaema
0.090 0.910 0.000
H21.2 Degeneration of iris and ciliary body
0.089 0.911 0.000
H18.2 Other corneal oedema
0.088 0.911 0.000
H18.0 Corneal pigmentations and deposits
0.082 0.917 0.000
H18.5 Hereditary corneal dystrophies
0.081 0.919 0.000
H21.9 Disorder of iris and ciliary body, unspecified
0.080 0.919 0.000
M48.56 Collapsed vertebra, not elsewhere classified (Lumbar region)
0.079 0.921 0.000
E86 Volume depletion
0.000 0.921 0.079
M48.59 Collapsed vertebra, not elsewhere classified (Site unspecified)
0.078 0.922 0.000
M49 Spondylopathies in diseases classified elsewhere
0.077 0.923 0.000
E04 Other non-toxic goitre
0.001 0.926 0.073
M48.54 Collapsed vertebra, not elsewhere classified (Thoracic region)
0.074 0.926 0.000
H18.9 Disorder of cornea, unspecified
0.074 0.926 0.000
J45.9 Asthma, unspecified
0.000 0.928 0.072
H21.1 Other vascular disorders of iris and ciliary body
0.070 0.929 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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