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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs2844641
log Bayes Factor = 71.1998
Chromosome 6   position 31,037,794  (GRCh37) Explore rs2844641 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E03.9 Hypothyroidism, unspecified
1.000 0.000 0.000
K90.0 Coeliac disease
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
R31 Unspecified haematuria
1.000 0.000 0.000
L40.9 Psoriasis, unspecified
0.000 0.001 0.999
E10-E14 Diabetes mellitus
0.000 0.001 0.999
E10.1 With ketoacidosis
0.000 0.002 0.998
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.003 0.997
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.004 0.996
E16.2 Hypoglycaemia, unspecified
0.000 0.004 0.996
E10.9 Without complications
0.000 0.004 0.996
E16 Other disorders of pancreatic internal secretion
0.000 0.004 0.996
E10.3 With ophthalmic complications
0.000 0.006 0.994
L40 Psoriasis
0.000 0.016 0.984
D86.9 Sarcoidosis, unspecified
0.000 0.019 0.981
D86 Sarcoidosis
0.000 0.019 0.981
E00-E07 Disorders of thyroid gland
0.050 0.022 0.928
D80-D89 Certain disorders involving the immune mechanism
0.000 0.031 0.969
L40.5 Arthropathic psoriasis
0.000 0.033 0.967
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.000 0.038 0.962
D70-D77 Other diseases of blood and blood-forming organs
0.000 0.043 0.957
D70 Agranulocytosis
0.000 0.048 0.952
E05 Thyrotoxicosis [hyperthyroidism]
0.008 0.065 0.927
L40.0 Psoriasis vulgaris
0.000 0.067 0.933
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.069 0.931
D50-D53 Nutritional anaemias
0.000 0.072 0.928
E11 Non-insulin-dependent diabetes mellitus
0.000 0.083 0.917
D51 Vitamin B12 deficiency anaemia
0.000 0.094 0.906
D86.1 Sarcoidosis of lymph nodes
0.000 0.096 0.904
E10.2 With renal complications
0.000 0.106 0.894
E10.8 With unspecified complications
0.000 0.107 0.893
E10.4 With neurological complications
0.000 0.130 0.870
D51.0 Vitamin B12 deficiency anaemia due to intrinsic factor deficiency
0.000 0.136 0.864
E11.3 With ophthalmic complications
0.000 0.151 0.849
D72 Other disorders of white blood cells
0.000 0.156 0.844
E50-E64 Other nutritional deficiencies
0.000 0.163 0.837
E11.5 With peripheral circulatory complications
0.000 0.172 0.828
E10.5 With peripheral circulatory complications
0.000 0.173 0.827
D86.0 Sarcoidosis of lung
0.000 0.176 0.824
E10.6 With other specified complications
0.000 0.178 0.822
E11.4 With neurological complications
0.000 0.184 0.816
D51.9 Vitamin B12 deficiency anaemia, unspecified
0.000 0.191 0.809
D53 Other nutritional anaemias
0.000 0.206 0.794
D75 Other diseases of blood and blood-forming organs
0.000 0.209 0.791
E55 Vitamin D deficiency
0.000 0.211 0.789
D86.8 Sarcoidosis of other and combined sites
0.000 0.219 0.781
D55-D59 Haemolytic anaemias
0.000 0.219 0.781
D80 Immunodeficiency with predominantly antibody defects
0.000 0.221 0.779
D72.8 Other specified disorders of white blood cells
0.000 0.230 0.770
E03 Other hypothyroidism
0.418 0.234 0.349
D83 Common variable immunodeficiency
0.000 0.235 0.765
E10.0 With coma
0.000 0.236 0.764
L40.4 Guttate psoriasis
0.000 0.240 0.760
E14 Unspecified diabetes mellitus
0.000 0.244 0.756
E55.9 Vitamin D deficiency, unspecified
0.000 0.246 0.754
D86.2 Sarcoidosis of lung with sarcoidosis of lymph nodes
0.000 0.249 0.751
E11.8 With unspecified complications
0.000 0.249 0.751
D59 Acquired haemolytic anaemia
0.000 0.265 0.735
L40.1 Generalised pustular psoriasis
0.000 0.266 0.733
D86.3 Sarcoidosis of skin
0.000 0.267 0.733
E11.1 With ketoacidosis
0.000 0.268 0.732
E10.7 With multiple complications
0.000 0.283 0.717
E12 Malnutrition-related diabetes mellitus
0.000 0.283 0.716
E15 Nondiabetic hypoglycaemic coma
0.000 0.286 0.714
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.286 0.714
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.286 0.714
E16.4 Abnormal secretion of gastrin
0.000 0.286 0.714
E16.3 Increased secretion of glucagon
0.000 0.286 0.714
E13 Other specified diabetes mellitus
0.000 0.291 0.709
L40.3 Pustulosis palmaris et plantaris
0.000 0.294 0.705
L40.2 Acrodermatitis continua
0.000 0.294 0.705
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.036 0.299 0.665
E00 Congenital iodine-deficiency syndrome
0.036 0.299 0.665
D53.9 Nutritional anaemia, unspecified
0.000 0.303 0.697
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions
0.000 0.305 0.695
D81 Combined immunodeficiencies
0.000 0.305 0.695
E40-E46 Malnutrition
0.000 0.307 0.693
D74 Methaemoglobinaemia
0.000 0.314 0.686
D77 Other disorders of blood and blood-forming organs in diseases classified elsewhere
0.000 0.314 0.686
D71 Functional disorders of polymorphonuclear neutrophils
0.000 0.314 0.686
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.318 0.682
E16.1 Other hypoglycaemia
0.000 0.319 0.681
D75.9 Disease of blood and blood-forming organs, unspecified
0.000 0.320 0.680
E02 Subclinical iodine-deficiency hypothyroidism
0.035 0.323 0.643
E05.5 Thyroid crisis or storm
0.006 0.330 0.665
E05.4 Thyrotoxicosis factitia
0.006 0.330 0.665
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.006 0.330 0.665
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.006 0.330 0.665
D82 Immunodeficiency associated with other major defects
0.000 0.335 0.665
D59.9 Acquired haemolytic anaemia, unspecified
0.000 0.336 0.664
E11.6 With other specified complications
0.000 0.338 0.662
E11.7 With multiple complications
0.000 0.342 0.658
D51.8 Other vitamin B12 deficiency anaemias
0.000 0.350 0.650
D51.3 Other dietary vitamin B12 deficiency anaemia
0.000 0.350 0.650
D51.2 Transcobalamin II deficiency
0.000 0.350 0.650
D51.1 Vitamin B12 deficiency anaemia due to selective vitamin B12 malabsorption with proteinuria
0.000 0.350 0.650
E06 Thyroiditis
0.026 0.353 0.620
E14.3 With ophthalmic complications
0.000 0.357 0.643
D76 Certain diseases involving lymphoreticular tissue and reticulohistiocytic system
0.000 0.360 0.639
D80.1 Nonfamilial hypogammaglobulinaemia
0.000 0.361 0.639
D59.1 Other autoimmune haemolytic anaemias
0.000 0.363 0.637
E05.8 Other thyrotoxicosis
0.006 0.369 0.625
E51 Thiamine deficiency
0.000 0.370 0.630
D75.0 Familial erythrocytosis
0.000 0.379 0.621
D83.9 Common variable immunodeficiency, unspecified
0.000 0.380 0.619
E53 Deficiency of other B group vitamins
0.000 0.383 0.617
D80.2 Selective deficiency of immunoglobulin A [IgA]
0.000 0.389 0.611
D50 Iron deficiency anaemia
0.000 0.392 0.608
D72.9 Disorder of white blood cells, unspecified
0.000 0.395 0.605
D72.0 Genetic anomalies of leukocytes
0.000 0.395 0.605
D80.3 Selective deficiency of immunoglobulin G [IgG] subclasses
0.000 0.397 0.603
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.400 0.600
E63 Other nutritional deficiencies
0.000 0.400 0.600
E50 Vitamin A deficiency
0.000 0.400 0.600
E60 Dietary zinc deficiency
0.000 0.400 0.600
E59 Dietary selenium deficiency
0.000 0.400 0.600
E52 Niacin deficiency [pellagra]
0.000 0.400 0.600
E14.8 With unspecified complications
0.000 0.400 0.600
E83.1 Disorders of iron metabolism
0.000 0.402 0.598
D84 Other immunodeficiencies
0.000 0.413 0.587
E14.1 With ketoacidosis
0.000 0.415 0.585
D72.1 Eosinophilia
0.000 0.419 0.581
E54 Ascorbic acid deficiency
0.000 0.423 0.576
D75.2 Essential thrombocytosis
0.000 0.427 0.573
D53.8 Other specified nutritional anaemias
0.000 0.431 0.569
D53.2 Scorbutic anaemia
0.000 0.431 0.569
D53.1 Other megaloblastic anaemias, not elsewhere classified
0.000 0.431 0.569
D53.0 Protein deficiency anaemia
0.000 0.431 0.569
E55.0 Rickets, active
0.000 0.434 0.565
D66 Hereditary factor VIII deficiency
0.000 0.435 0.565
E14.6 With other specified complications
0.000 0.436 0.564
D55 Anaemia due to enzyme disorders
0.000 0.440 0.560
D80.8 Other immunodeficiencies with predominantly antibody defects
0.000 0.442 0.558
D80.7 Transient hypogammaglobulinaemia of infancy
0.000 0.442 0.558
D80.6 Antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinaemia
0.000 0.442 0.558
D80.5 Immunodeficiency with increased immunoglobulin M [IgM]
0.000 0.442 0.558
D80.0 Hereditary hypogammaglobulinaemia
0.000 0.442 0.558
D65 Disseminated intravascular coagulation [defibrination syndrome]
0.000 0.444 0.556
E05.9 Thyrotoxicosis, unspecified
0.000 0.446 0.553
E58 Dietary calcium deficiency
0.000 0.447 0.552
E07 Other disorders of thyroid
0.064 0.448 0.488
E03.5 Myxoedema coma
0.299 0.451 0.250
E03.4 Atrophy of thyroid (acquired)
0.299 0.451 0.250
E03.3 Postinfectious hypothyroidism
0.299 0.451 0.250
D83.8 Other common variable immunodeficiencies
0.000 0.451 0.549
D83.2 Common variable immunodeficiency with autoantibodies to B- or T-cells
0.000 0.451 0.549
D83.1 Common variable immunodeficiency with predominant immunoregulatory T-cell disorders
0.000 0.451 0.549
D83.0 Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function
0.000 0.451 0.549
E56 Other vitamin deficiencies
0.000 0.454 0.546
E70-E90 Metabolic disorders
0.000 0.456 0.544
E06.9 Thyroiditis, unspecified
0.011 0.457 0.532
E14.7 With multiple complications
0.000 0.458 0.542
E14.2 Withrenal complications
0.000 0.458 0.542
E14.0 With coma
0.000 0.458 0.542
D89 Other disorders involving the immune mechanism, not elsewhere classified
0.000 0.459 0.541
E03.0 Congenital hypothyroidism with diffuse goitre
0.297 0.460 0.244
D69 Purpura and other haemorrhagic conditions
0.000 0.461 0.539
E83 Disorders of mineral metabolism
0.000 0.461 0.539
D57 Sickle-cell disorders
0.000 0.466 0.534
E03.1 Congenital hypothyroidism without goitre
0.264 0.468 0.268
E13.9 Without complications
0.000 0.469 0.531
D75.8 Other specified diseases of blood and blood-forming organs
0.000 0.471 0.529
E14.4 With neurological complications
0.000 0.471 0.529
D59.8 Other acquired haemolytic anaemias
0.000 0.473 0.527
D59.6 Haemoglobinuria due to haemolysis from other external causes
0.000 0.473 0.527
D59.5 Paroxysmal nocturnal haemoglobinuria [Marchiafava-Micheli]
0.000 0.473 0.527
D59.4 Other nonautoimmune haemolytic anaemias
0.000 0.473 0.527
D59.3 Haemolytic-uraemic syndrome
0.000 0.473 0.527
D59.2 Drug-induced nonautoimmune haemolytic anaemia
0.000 0.473 0.527
D59.0 Drug-induced autoimmune haemolytic anaemia
0.000 0.473 0.527
E65-E68 Obesity and other hyperalimentation
0.000 0.476 0.524
E14.5 With peripheral circulatory complications
0.000 0.476 0.523
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.006 0.477 0.517
D80.9 Immunodeficiency with predominantly antibody defects, unspecified
0.000 0.478 0.521
L40.8 Other psoriasis
0.000 0.479 0.521
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.310 0.480 0.209
E04 Other non-toxic goitre
0.003 0.482 0.515
D75.1 Secondary polycythaemia
0.000 0.483 0.517
E12.9 Without complications
0.000 0.486 0.514
E12.8 With unspecified complications
0.000 0.486 0.514
E12.7 With multiple complications
0.000 0.486 0.514
E12.6 With other specified complications
0.000 0.486 0.514
E12.5 With peripheral circulatory complications
0.000 0.486 0.514
E12.4 With neurological complications
0.000 0.486 0.514
E12.3 With ophthalmic complications
0.000 0.486 0.514
E12.2 With renal complications
0.000 0.486 0.514
E12.1 With ketoacidosis
0.000 0.486 0.514
E12.0 With coma
0.000 0.486 0.514
E13.8 With unspecified complications
0.000 0.491 0.509
E13.7 With multiple complications
0.000 0.491 0.509
E13.6 With other specified complications
0.000 0.491 0.509
E13.5 With peripheral circulatory complications
0.000 0.491 0.509
E13.4 With neurological complications
0.000 0.491 0.509
E13.2 With renal complications
0.000 0.491 0.509
E13.1 With ketoacidosis
0.000 0.491 0.509
E13.0 With coma
0.000 0.491 0.509
D67 Hereditary factor IX deficiency
0.000 0.492 0.508
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.026 0.497 0.477
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.026 0.497 0.477
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.026 0.497 0.477
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.026 0.497 0.477
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.026 0.497 0.477
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.026 0.497 0.477
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.026 0.497 0.477
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.026 0.497 0.477
D50.9 Iron deficiency anaemia, unspecified
0.000 0.500 0.500
D81.9 Combined immunodeficiency, unspecified
0.000 0.502 0.498
D81.8 Other combined immunodeficiencies
0.000 0.502 0.498
D81.7 Major histocompatibility complex class II deficiency
0.000 0.502 0.498
D81.6 Major histocompatibility complex class I deficiency
0.000 0.502 0.498
D81.5 Purine nucleoside phosphorylase [PNP] deficiency
0.000 0.502 0.498
D81.4 Nezelof's syndrome
0.000 0.502 0.498
D81.3 Adenosine deaminase [ADA] deficiency
0.000 0.502 0.498
D81.2 Severe combined immunodeficiency [SCID] with low or normal B-cell numbers
0.000 0.502 0.498
D81.1 Severe combined immunodeficiency [SCID] with low T- and B-cell numbers
0.000 0.502 0.498
D81.0 Severe combined immunodeficiency [SCID] with reticular dysgenesis
0.000 0.502 0.498
D58 Other hereditary haemolytic anaemias
0.000 0.502 0.497
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.503 0.497
E45 Retarded development following protein-energy malnutrition
0.000 0.503 0.497
E43 Unspecified severe protein-energy malnutrition
0.000 0.503 0.497
E42 Marasmic kwashiorkor
0.000 0.503 0.497
E41 Nutritional marasmus
0.000 0.503 0.497
E40 Kwashiorkor
0.000 0.503 0.497
D74.9 Methaemoglobinaemia, unspecified
0.000 0.508 0.492
D74.8 Other methaemoglobinaemias
0.000 0.508 0.492
D74.0 Congenital methaemoglobinaemia
0.000 0.508 0.492
E03.8 Other specified hypothyroidism
0.267 0.511 0.221
E88 Other metabolic disorders
0.000 0.515 0.485
E51.2 Wernicke's encephalopathy
0.000 0.519 0.481
D82.9 Immunodeficiency associated with major defect, unspecified
0.000 0.523 0.477
D82.8 Immunodeficiency associated with other specified major defects
0.000 0.523 0.477
D82.4 Hyperimmunoglobulin E [IgE] syndrome
0.000 0.523 0.477
D82.3 Immunodeficiency following hereditary defective response to Epstein-Barr virus
0.000 0.523 0.477
D82.2 Immunodeficiency with short-limbed stature
0.000 0.523 0.477
D82.0 Wiskott-Aldrich syndrome
0.000 0.523 0.477
E13.3 With ophthalmic complications
0.000 0.524 0.476
E46 Unspecified protein-energy malnutrition
0.000 0.525 0.475
E53.9 Vitamin B deficiency, unspecified
0.000 0.525 0.475
D50.8 Other iron deficiency anaemias
0.000 0.526 0.474
D80.4 Selective deficiency of immunoglobulin M [IgM]
0.000 0.526 0.473
E85 Amyloidosis
0.000 0.528 0.472
E06.4 Drug-induced thyroiditis
0.019 0.536 0.445
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.019 0.536 0.445
E06.0 Acute thyroiditis
0.019 0.536 0.445
D52 Folate deficiency anaemia
0.000 0.539 0.461
D84.1 Defects in the complement system
0.000 0.541 0.459
D76.2 Haemophagocytic syndrome, infection-associated
0.000 0.541 0.459
D76.1 Haemophagocytic lymphohistiocytosis
0.000 0.541 0.459
D76.0 Langerhans' cell histiocytosis, not elsewhere classified
0.000 0.541 0.459
D69.6 Thrombocytopenia, unspecified
0.000 0.541 0.459
E20-E35 Disorders of other endocrine glands
0.000 0.544 0.456
K90 Intestinal malabsorption
0.000 0.547 0.453
E27.1 Primary adrenocortical insufficiency
0.000 0.548 0.452
E51.9 Thiamine deficiency, unspecified
0.000 0.548 0.451
E51.8 Other manifestations of thiamine deficiency
0.000 0.548 0.451
E51.1 Beriberi
0.000 0.548 0.451
D69.2 Other nonthrombocytopenic purpura
0.000 0.550 0.450
E27 Other disorders of adrenal gland
0.000 0.551 0.449
D82.1 Di George's syndrome
0.000 0.553 0.447
D69.5 Secondary thrombocytopenia
0.000 0.556 0.444
E53.1 Pyridoxine deficiency
0.000 0.557 0.443
E53.0 Riboflavin deficiency
0.000 0.557 0.443
D50.1 Sideropenic dysphagia
0.000 0.564 0.436
E88.0 Disorders of plasma-protein metabolism, not elsewhere classified
0.000 0.566 0.434
E50.9 Vitamin A deficiency, unspecified
0.000 0.569 0.430
E50.8 Other manifestations of vitamin A deficiency
0.000 0.569 0.430
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.569 0.430
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.569 0.430
E50.5 Vitamin A deficiency with night blindness
0.000 0.569 0.430
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.569 0.430
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.569 0.430
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.569 0.430
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.569 0.430
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.569 0.430
E63.9 Nutritional deficiency, unspecified
0.000 0.569 0.430
E63.8 Other specified nutritional deficiencies
0.000 0.569 0.430
E63.1 Imbalance of constituents of food intake
0.000 0.569 0.430
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.569 0.430
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.569 0.430
E64.8 Sequelae of other nutritional deficiencies
0.000 0.569 0.430
E64.3 Sequelae of rickets
0.000 0.569 0.430
E64.2 Sequelae of vitamin C deficiency
0.000 0.569 0.430
E64.1 Sequelae of vitamin A deficiency
0.000 0.569 0.430
E64.0 Sequelae of protein-energy malnutrition
0.000 0.569 0.430
E04.0 Non-toxic diffuse goitre
0.001 0.569 0.429
E07.8 Other specified disorders of thyroid
0.032 0.575 0.393
E53.8 Deficiency of other specified B group vitamins
0.000 0.576 0.424
E85.4 Organ-limited amyloidosis
0.000 0.577 0.423
D84.8 Other specified immunodeficiencies
0.000 0.579 0.421
D84.0 Lymphocyte function antigen-1 [LFA-1] defect
0.000 0.579 0.421
E61 Deficiency of other nutrient elements
0.000 0.585 0.415
D76.3 Other histiocytosis syndromes
0.000 0.588 0.412
E11.2 With renal complications
0.000 0.588 0.412
D89.8 Other specified disorders involving the immune mechanism, not elsewhere classified
0.000 0.589 0.411
E06.3 Autoimmune thyroiditis
0.011 0.589 0.400
E79 Disorders of purine and pyrimidine metabolism
0.000 0.590 0.410
E04.9 Non-toxic goitre, unspecified
0.000 0.594 0.406
E70 Disorders of aromatic amino-acid metabolism
0.000 0.595 0.405
E06.1 Subacute thyroiditis
0.021 0.596 0.383
D55.9 Anaemia due to enzyme disorder, unspecified
0.000 0.598 0.402
D55.8 Other anaemias due to enzyme disorders
0.000 0.598 0.402
D55.3 Anaemia due to disorders of nucleotide metabolism
0.000 0.598 0.402
D55.2 Anaemia due to disorders of glycolytic enzymes
0.000 0.598 0.402
D55.1 Anaemia due to other disorders of glutathione metabolism
0.000 0.598 0.402
D55.0 Anaemia due to glucose-6-phosphate dehydrogenase [G6PD] deficiency
0.000 0.598 0.402
D89.9 Disorder involving the immune mechanism, unspecified
0.000 0.598 0.402
E07.1 Dyshormogenetic goitre
0.046 0.604 0.350
E07.0 Hypersecretion of calcitonin
0.046 0.604 0.350
E56.9 Vitamin deficiency, unspecified
0.000 0.608 0.392
E56.8 Deficiency of other vitamins
0.000 0.608 0.392
E56.0 Deficiency of vitamin E
0.000 0.608 0.392
E77 Disorders of glycoprotein metabolism
0.000 0.610 0.390
E76 Disorders of glycosaminoglycan metabolism
0.000 0.610 0.390
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.000 0.610 0.390
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.000 0.610 0.390
E88.1 Lipodystrophy, not elsewhere classified
0.000 0.610 0.390
D89.3 Immune reconstitution syndrome
0.000 0.612 0.388
E11.0 With coma
0.001 0.612 0.387
D69.8 Other specified haemorrhagic conditions
0.000 0.613 0.387
E83.8 Other disorders of mineral metabolism
0.000 0.614 0.386
E83.2 Disorders of zinc metabolism
0.000 0.614 0.386
E83.0 Disorders of copper metabolism
0.000 0.614 0.386
E06.5 Other chronic thyroiditis
0.022 0.616 0.363
D57.8 Other sickle-cell disorders
0.000 0.617 0.383
D57.3 Sickle-cell trait
0.000 0.617 0.383
D57.2 Double heterozygous sickling disorders
0.000 0.617 0.383
D57.0 Sickle-cell anaemia with crisis
0.000 0.617 0.383
D69.9 Haemorrhagic condition, unspecified
0.000 0.618 0.382
D69.3 Idiopathic thrombocytopenic purpura
0.000 0.619 0.381
E88.9 Metabolic disorder, unspecified
0.000 0.620 0.379
E34 Other endocrine disorders
0.000 0.623 0.377
E67 Other hyperalimentation
0.000 0.624 0.376
E68 Sequelae of hyperalimentation
0.000 0.624 0.376
D89.1 Cryoglobulinaemia
0.000 0.626 0.373
E04.8 Other specified non-toxic goitre
0.002 0.629 0.369
E83.9 Disorder of mineral metabolism, unspecified
0.000 0.629 0.371
D58.2 Other haemoglobinopathies
0.000 0.631 0.368
K90.9 Intestinal malabsorption, unspecified
0.000 0.634 0.366
D69.1 Qualitative platelet defects
0.000 0.634 0.366
E84 Cystic fibrosis
0.000 0.635 0.365
E20 Hypoparathyroidism
0.000 0.642 0.358
E72 Other disorders of amino-acid metabolism
0.000 0.642 0.358
D58.8 Other specified hereditary haemolytic anaemias
0.000 0.643 0.357
D58.1 Hereditary elliptocytosis
0.000 0.643 0.357
D57.1 Sickle-cell anaemia without crisis
0.000 0.643 0.356
E44.1 Mild protein-energy malnutrition
0.000 0.643 0.356
E44.0 Moderate protein-energy malnutrition
0.000 0.643 0.356
D56 Thalassaemia
0.001 0.646 0.353
E85.3 Secondary systemic amyloidosis
0.000 0.651 0.349
E88.3 Tumour lysis syndrome
0.000 0.654 0.346
E27.3 Drug-induced adrenocortical insufficiency
0.000 0.655 0.345
D69.4 Other primary thrombocytopenia
0.000 0.659 0.341
E85.8 Other amyloidosis
0.000 0.662 0.338
E85.2 Heredofamilial amyloidosis, unspecified
0.000 0.662 0.338
E85.1 Neuropathic heredofamilial amyloidosis
0.000 0.662 0.338
E85.0 Nonneuropathic heredofamilial amyloidosis
0.000 0.662 0.338
E56.1 Deficiency of vitamin K
0.000 0.662 0.338
E74 Other disorders of carbohydrate metabolism
0.000 0.667 0.332
E25 Adrenogenital disorders
0.000 0.668 0.332
E66 Obesity
0.000 0.668 0.332
D52.8 Other folate deficiency anaemias
0.000 0.669 0.330
D52.1 Drug-induced folate deficiency anaemia
0.000 0.669 0.330
D52.0 Dietary folate deficiency anaemia
0.000 0.669 0.330
E88.8 Other specified metabolic disorders
0.000 0.671 0.329
E34.9 Endocrine disorder, unspecified
0.000 0.671 0.329
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.673 0.327
E32 Diseases of thymus
0.000 0.673 0.327
E31 Polyglandular dysfunction
0.000 0.673 0.327
E30 Disorders of puberty, not elsewhere classified
0.000 0.673 0.327
D58.9 Hereditary haemolytic anaemia, unspecified
0.000 0.674 0.326
K90.3 Pancreatic steatorrhoea
0.000 0.675 0.325
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.675 0.325
K90.1 Tropical sprue
0.000 0.675 0.325
E27.5 Adrenomedullary hyperfunction
0.000 0.678 0.322
E27.0 Other adrenocortical overactivity
0.000 0.678 0.322
D89.0 Polyclonal hypergammaglobulinaemia
0.000 0.681 0.319
E27.2 Addisonian crisis
0.000 0.681 0.318
E85.9 Amyloidosis, unspecified
0.000 0.683 0.317
D58.0 Hereditary spherocytosis
0.000 0.684 0.315
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
0.000 0.686 0.314
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.000 0.686 0.314
K90.8 Other intestinal malabsorption
0.000 0.686 0.313
E73 Lactose intolerance
0.000 0.693 0.307
E70.3 Albinism
0.000 0.695 0.305
E34.0 Carcinoid syndrome
0.000 0.698 0.302
E61.9 Deficiency of nutrient element, unspecified
0.000 0.702 0.297
E61.8 Deficiency of other specified nutrient elements
0.000 0.702 0.297
E61.7 Deficiency of multiple nutrient elements
0.000 0.702 0.297
E61.6 Vanadium deficiency
0.000 0.702 0.297
E61.5 Molybdenum deficiency
0.000 0.702 0.297
E61.4 Chromium deficiency
0.000 0.702 0.297
E61.3 Manganese deficiency
0.000 0.702 0.297
E61.0 Copper deficiency
0.000 0.702 0.297
E88.2 Lipomatosis, not elsewhere classified
0.000 0.704 0.296
E27.8 Other specified disorders of adrenal gland
0.000 0.705 0.294
E79.9 Disorder of purine and pyrimidine metabolism, unspecified
0.000 0.706 0.294
E79.8 Other disorders of purine and pyrimidine metabolism
0.000 0.706 0.294
E79.1 Lesch-Nyhan syndrome
0.000 0.706 0.294
E70.9 Disorder of aromatic amino-acid metabolism, unspecified
0.000 0.709 0.290
E70.8 Other disorders of aromatic amino-acid metabolism
0.000 0.709 0.290
E70.2 Disorders of tyrosine metabolism
0.000 0.709 0.290
E70.1 Other hyperphenylalaninaemias
0.000 0.709 0.290
E70.0 Classical phenylketonuria
0.000 0.709 0.290
D89.2 Hypergammaglobulinaemia, unspecified
0.000 0.710 0.290
E20.9 Hypoparathyroidism, unspecified
0.000 0.712 0.288
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.000 0.713 0.287
E66.2 Extreme obesity with alveolar hypoventilation
0.000 0.717 0.283
E71.3 Disorders of fatty-acid metabolism
0.000 0.720 0.280
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified
0.000 0.720 0.280
E71.1 Other disorders of branched-chain amino-acid metabolism
0.000 0.720 0.280
E71.0 Maple-syrup-urine disease
0.000 0.720 0.280
E76.9 Disorder of glucosaminoglycan metabolism, unspecified
0.000 0.720 0.280
E76.8 Other disorders of glucosaminoglycan metabolism
0.000 0.720 0.280
E76.3 Mucopolysaccharidosis, unspecified
0.000 0.720 0.280
E76.2 Other mucopolysaccharidoses
0.000 0.720 0.280
E76.1 Mucopolysaccharidosis, type II
0.000 0.720 0.280
E76.0 Mucopolysaccharidosis, type I
0.000 0.720 0.280
E77.9 Disorder of glycoprotein metabolism, unspecified
0.000 0.720 0.280
E77.8 Other disorders of glycoprotein metabolism
0.000 0.720 0.280
E77.1 Defects in glycoprotein degradation
0.000 0.720 0.280
E77.0 Defects in posttranslational modification of lysosomal enzymes
0.000 0.720 0.280
E86 Volume depletion
0.000 0.722 0.278
E22 Hyperfunction of pituitary gland
0.000 0.723 0.277
E66.0 Obesity due to excess calories
0.000 0.724 0.276
E24 Cushing's syndrome
0.000 0.726 0.274
E34.5 Androgen resistance syndrome
0.000 0.730 0.270
E34.4 Constitutional tall stature
0.000 0.730 0.270
E34.2 Ectopic hormone secretion, not elsewhere classified
0.000 0.730 0.270
E34.1 Other hypersecretion of intestinal hormones
0.000 0.730 0.270
E67.8 Other specified hyperalimentation
0.000 0.730 0.269
E67.3 Hypervitaminosis D
0.000 0.730 0.269
E67.2 Megavitamin-B6 syndrome
0.000 0.730 0.269
E67.1 Hypercarotenaemia
0.000 0.730 0.269
E67.0 Hypervitaminosis A
0.000 0.730 0.269
E27.4 Other and unspecified adrenocortical insufficiency
0.000 0.734 0.266
E29 Testicular dysfunction
0.000 0.736 0.263
E84.8 Cystic fibrosis with other manifestations
0.000 0.738 0.262
E84.1 Cystic fibrosis with intestinal manifestations
0.000 0.738 0.262
E84.0 Cystic fibrosis with pulmonary manifestations
0.000 0.738 0.262
E65 Localised adiposity
0.000 0.738 0.262
E61.2 Magnesium deficiency
0.000 0.738 0.261
E34.3 Short stature, not elsewhere classified
0.000 0.740 0.259
E20.8 Other hypoparathyroidism
0.000 0.743 0.257
E20.1 Pseudohypoparathyroidism
0.000 0.743 0.257
E20.0 Idiopathic hypoparathyroidism
0.000 0.743 0.257
E72.9 Disorder of amino-acid metabolism, unspecified
0.000 0.743 0.257
E72.8 Other specified disorders of amino-acid metabolism
0.000 0.743 0.257
E72.5 Disorders of glycine metabolism
0.000 0.743 0.257
E72.4 Disorders of ornithine metabolism
0.000 0.743 0.257
E72.3 Disorders of lysine and hydroxylysine metabolism
0.000 0.743 0.257
E72.2 Disorders of urea cycle metabolism
0.000 0.743 0.257
E72.1 Disorders of sulphur-bearing amino-acid metabolism
0.000 0.743 0.257
D73 Diseases of spleen
0.000 0.743 0.257
D56.9 Thalassaemia, unspecified
0.001 0.746 0.253
D56.8 Other thalassaemias
0.001 0.746 0.253
D56.4 Hereditary persistence of foetal haemoglobin [HPFH]
0.001 0.746 0.253
D56.2 Delta-beta thalassaemia
0.001 0.746 0.253
D56.0 Alpha thalassaemia
0.001 0.746 0.253
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.000 0.757 0.242
E74.9 Disorder of carbohydrate metabolism, unspecified
0.000 0.761 0.238
E74.8 Other specified disorders of carbohydrate metabolism
0.000 0.761 0.238
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
0.000 0.761 0.238
E74.2 Disorders of galactose metabolism
0.000 0.761 0.238
E74.1 Disorders of fructose metabolism
0.000 0.761 0.238
E74.0 Glycogen storage disease
0.000 0.761 0.238
E25.9 Adrenogenital disorder, unspecified
0.000 0.762 0.238
E25.8 Other adrenogenital disorders
0.000 0.762 0.238
E66.1 Drug-induced obesity
0.000 0.762 0.238
E04.1 Non-toxic single thyroid nodule
0.001 0.762 0.237
E84.9 Cystic fibrosis, unspecified
0.000 0.763 0.237
E30.9 Disorder of puberty, unspecified
0.000 0.765 0.235
E30.8 Other disorders of puberty
0.000 0.765 0.235
E30.1 Precocious puberty
0.000 0.765 0.235
E30.0 Delayed puberty
0.000 0.765 0.235
E31.9 Polyglandular dysfunction, unspecified
0.000 0.765 0.235
E31.8 Other polyglandular dysfunction
0.000 0.765 0.235
E31.1 Polyglandular hyperfunction
0.000 0.765 0.235
E31.0 Autoimmune polyglandular failure
0.000 0.765 0.235
E32.9 Disease of thymus, unspecified
0.000 0.765 0.235
E32.8 Other diseases of thymus
0.000 0.765 0.235
E32.1 Abscess of thymus
0.000 0.765 0.235
E32.0 Persistent hyperplasia of thymus
0.000 0.765 0.235
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.765 0.235
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.765 0.235
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.765 0.235
D84.9 Immunodeficiency, unspecified
0.001 0.768 0.231
E26 Hyperaldosteronism
0.000 0.772 0.228
E75.6 Lipid storage disorder, unspecified
0.000 0.775 0.225
E75.4 Neuronal ceroid lipofuscinosis
0.000 0.775 0.225
E75.3 Sphingolipidosis, unspecified
0.000 0.775 0.225
E75.1 Other gangliosidosis
0.000 0.775 0.225
E75.0 GM2 gangliosidosis
0.000 0.775 0.225
E72.0 Disorders of amino-acid transport
0.000 0.775 0.225
E80 Disorders of porphyrin and bilirubin metabolism
0.000 0.776 0.223
E22.1 Hyperprolactinaemia
0.000 0.778 0.222
E73.8 Other lactose intolerance
0.000 0.780 0.220
E73.1 Secondary lactase deficiency
0.000 0.780 0.220
E73.0 Congenital lactase deficiency
0.000 0.780 0.220
D60-D64 Aplastic and other anaemias
0.000 0.781 0.219
E14.9 Without complications
0.000 0.784 0.216

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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