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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs2844659
log Bayes Factor = 220.674
Chromosome 6   position 30,824,532  (GRCh37) Explore rs2844659 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E03.9 Hypothyroidism, unspecified
1.000 0.000 0.000
E05.9 Thyrotoxicosis, unspecified
1.000 0.000 0.000
E05.0 Thyrotoxicosis with diffuse goitre
1.000 0.000 0.000
E10.9 Without complications
1.000 0.000 0.000
K90.0 Coeliac disease
1.000 0.000 0.000
M35.0 Sicca syndrome [Sjogren]
1.000 0.000 0.000
E05 Thyrotoxicosis [hyperthyroidism]
1.000 0.000 0.000
E10 Insulin-dependent diabetes mellitus
1.000 0.000 0.000
R31 Unspecified haematuria
0.000 0.000 1.000
E10-E14 Diabetes mellitus
1.000 0.000 0.000
E00-E07 Disorders of thyroid gland
1.000 0.000 0.000
Chapter IV Endocrine, nutritional and metabolic diseases
1.000 0.000 0.000
E03 Other hypothyroidism
1.000 0.000 0.000
# Top node
1.000 0.000 0.000
E10.3 With ophthalmic complications
1.000 0.000 0.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
1.000 0.000 0.000
D80-D89 Certain disorders involving the immune mechanism
0.999 0.001 0.000
D86 Sarcoidosis
0.999 0.001 0.000
K90 Intestinal malabsorption
0.998 0.002 0.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.997 0.003 0.000
M35 Other systemic involvement of connective tissue
0.997 0.003 0.000
D86.9 Sarcoidosis, unspecified
0.996 0.004 0.000
M20-M25 Other joint disorders
0.996 0.004 0.000
E20-E35 Disorders of other endocrine glands
0.996 0.004 0.000
E16 Other disorders of pancreatic internal secretion
0.995 0.005 0.000
Chapter I Certain infectious and parasitic diseases
0.995 0.005 0.000
E16.2 Hypoglycaemia, unspecified
0.994 0.006 0.000
B35-B49 Mycoses
0.992 0.008 0.000
B37 Candidiasis
0.991 0.009 0.000
E27 Other disorders of adrenal gland
0.991 0.009 0.000
E10.2 With renal complications
0.991 0.009 0.000
B37.8 Candidiasis of other sites
0.990 0.010 0.000
E10.1 With ketoacidosis
0.990 0.010 0.000
E27.1 Primary adrenocortical insufficiency
0.989 0.011 0.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue
0.988 0.012 0.000
E14 Unspecified diabetes mellitus
0.987 0.013 0.000
K70-K77 Diseases of liver
0.969 0.031 0.000
K90-K93 Other diseases of the digestive system
0.969 0.031 0.000
Chapter XI Diseases of the digestive system
0.968 0.032 0.000
M24 Other specific joint derangements
0.967 0.033 0.000
K90.9 Intestinal malabsorption, unspecified
0.964 0.036 0.000
E14.3 With ophthalmic complications
0.961 0.039 0.000
B15-B19 Viral hepatitis
0.959 0.041 0.000
Chapter VII Diseases of the eye and adnexa
0.958 0.042 0.000
H00-H06 Disorders of eyelid, lacrimal system and orbit
0.956 0.044 0.000
K75 Other inflammatory liver diseases
0.953 0.047 0.000
K75.4 Autoimmune hepatitis
0.945 0.055 0.000
E10.4 With neurological complications
0.943 0.057 0.000
H06 Disorders of lachrymal system and orbit in diseases classified elsewhere
0.941 0.059 0.000
E11 Non-insulin-dependent diabetes mellitus
0.938 0.062 0.000
H05 Disorders of orbit
0.932 0.068 0.000
H06.2 Dysthyroid exophthalmos
0.931 0.069 0.000
E50-E64 Other nutritional deficiencies
0.931 0.069 0.000
K74 Fibrosis and cirrhosis of liver
0.926 0.074 0.000
E06 Thyroiditis
0.924 0.076 0.000
B18 Chronic viral hepatitis
0.921 0.079 0.000
M24.2 Disorder of ligament
0.919 0.081 0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.911 0.089 0.000
Chapter XII Diseases of the skin and subcutaneous tissue
0.910 0.090 0.000
D86.0 Sarcoidosis of lung
0.901 0.099 0.000
E23 Hypofunction and other disorders of pituitary gland
0.901 0.099 0.000
B37.9 Candidiasis, unspecified
0.901 0.099 0.000
K72 Hepatic failure, not elsewhere classified
0.901 0.099 0.000
B37.0 Candidal stomatitis
0.898 0.102 0.000
K73 Chronic hepatitis, not elsewhere classified
0.896 0.104 0.000
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.892 0.108 0.000
I70-I79 Diseases of arteries, arterioles and capillaries
0.890 0.110 0.000
I74 Arterial embolism and thrombosis
0.888 0.112 0.000
E07 Other disorders of thyroid
0.886 0.114 0.000
E11.5 With peripheral circulatory complications
0.885 0.115 0.000
I74.3 Embolism and thrombosis of arteries of the lower extremities
0.883 0.117 0.000
Chapter IX Diseases of the circulatory system
0.883 0.117 0.000
B18.2 Chronic viral hepatitis C
0.879 0.121 0.000
L80-L99 Other disorders of the skin and subcutaneous tissue
0.875 0.125 0.000
L10-L14 Bullous disorders
0.872 0.128 0.000
B20-B24 Human immunodeficiency virus [HIV] disease
0.872 0.128 0.000
M60-M63 Disorders of muscles
0.870 0.129 0.000
H30-H36 Disorders of choroid and retina
0.865 0.135 0.000
D83 Common variable immunodeficiency
0.864 0.136 0.000
M24.27 Disorder of ligament (Ankle and foot)
0.864 0.136 0.000
I73 Other peripheral vascular diseases
0.863 0.137 0.000
L97 Ulcer of lower limb, not elsewhere classified
0.859 0.141 0.000
H36 Retinal disorders in diseases classified elsewhere
0.859 0.141 0.000
H05.2 Exophthalmic conditions
0.859 0.141 0.000
M32 Systemic lupus erythematosus
0.856 0.144 0.000
H36.0 Diabetic retinopathy
0.856 0.144 0.000
Q50-Q56 Congenital malformations of genital organs
0.851 0.149 0.000
D80 Immunodeficiency with predominantly antibody defects
0.849 0.151 0.000
K74.3 Primary biliary cirrhosis
0.847 0.153 0.000
E29 Testicular dysfunction
0.847 0.153 0.000
E14.8 With unspecified complications
0.846 0.154 0.000
I79 Disorders of arteries, arterioles and capillaries in diseases classified elsewhere
0.844 0.156 0.000
L13 Other bullous disorders
0.844 0.156 0.000
Q38-Q45 Other congenital malformations of the digestive system
0.837 0.163 0.000
M86-M90 Other osteopathies
0.836 0.164 0.000
H05.8 Other disorders of orbit
0.835 0.165 0.000
M34 Systemic sclerosis
0.834 0.166 0.000
M21 Other acquired deformities of limbs
0.834 0.166 0.000
K74.6 Other and unspecified cirrhosis of liver
0.833 0.167 0.000
D86.1 Sarcoidosis of lymph nodes
0.832 0.168 0.000
B25-B34 Other viral diseases
0.832 0.168 0.000
E11.3 With ophthalmic complications
0.830 0.170 0.000
K72.9 Hepatic failure, unspecified
0.828 0.172 0.000
E61 Deficiency of other nutrient elements
0.828 0.172 0.000
L92 Granulomatous disorders of skin and subcutaneous tissue
0.825 0.175 0.000
H04 Disorders of lachrymal system
0.825 0.175 0.000
L13.0 Dermatitis herpetiformis
0.824 0.176 0.000
E06.3 Autoimmune thyroiditis
0.823 0.177 0.000
M25 Other joint disorders, not elsewhere classified
0.821 0.179 0.000
E14.2 Withrenal complications
0.820 0.179 0.000
L94 Other localised connective tissue disorders
0.815 0.185 0.000
E03.8 Other specified hypothyroidism
0.814 0.186 0.000
E14.1 With ketoacidosis
0.812 0.188 0.000
H03 Disorders of eyelid in diseases classified elsewhere
0.811 0.189 0.000
K75.8 Other specified inflammatory liver diseases
0.809 0.190 0.000
D86.8 Sarcoidosis of other and combined sites
0.808 0.192 0.000
M24.1 Other articular cartilage disorders
0.807 0.193 0.000
M24.7 Protrusio acetabuli
0.807 0.193 0.000
I79.2 Peripheral angiopathy in diseases classified elsewhere
0.807 0.193 0.000
D55-D59 Haemolytic anaemias
0.805 0.195 0.000
D60-D64 Aplastic and other anaemias
0.805 0.195 0.000
E16.0 Drug-induced hypoglycaemia without coma
0.799 0.201 0.000
I73.0 Raynaud's syndrome
0.796 0.204 0.000
E13 Other specified diabetes mellitus
0.795 0.205 0.000
E53 Deficiency of other B group vitamins
0.791 0.209 0.000
L92.3 Foreign body granuloma of skin and subcutaneous tissue
0.790 0.210 0.000
E27.4 Other and unspecified adrenocortical insufficiency
0.788 0.212 0.000
K73.2 Chronic active hepatitis, not elsewhere classified
0.787 0.213 0.000
A15-A19 Tuberculosis
0.786 0.214 0.000
M25.6 Stiffness of joint, not elsewhere classified
0.785 0.215 0.000
Q51 Congenital malformations of uterus and cervix
0.785 0.215 0.000
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.785 0.215 0.000
I73.9 Peripheral vascular disease, unspecified
0.784 0.216 0.000
H04.1 Other disorders of lachrymal gland
0.784 0.216 0.000
E11.6 With other specified complications
0.783 0.217 0.000
H05.0 Acute inflammation of orbit
0.783 0.217 0.000
E10.5 With peripheral circulatory complications
0.783 0.217 0.000
M24.5 Contracture of joint
0.781 0.219 0.000
M24.26 Disorder of ligament (Lower leg)
0.778 0.222 0.000
E23.2 Diabetes insipidus
0.778 0.222 0.000
L50-L54 Urticaria and erythema
0.778 0.222 0.000
Chapter XX External causes of morbidity and mortality
0.777 0.223 0.000
K73.9 Chronic hepatitis, unspecified
0.775 0.225 0.000
M86 Osteomyelitis
0.772 0.228 0.000
M25.66 Stiffness of joint, not elsewhere classified (Lower leg)
0.771 0.229 0.000
E06.9 Thyroiditis, unspecified
0.769 0.231 0.000
D83.9 Common variable immunodeficiency, unspecified
0.768 0.232 0.000
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions
0.766 0.234 0.000
B17 Other acute viral hepatitis
0.766 0.234 0.000
B24 Unspecified human immunodeficiency virus [HIV] disease
0.766 0.234 0.000
H43-H45 Disorders of vitreous body and globe
0.766 0.234 0.000
Q43 Other congenital malformations of intestine
0.766 0.234 0.000
E10.7 With multiple complications
0.764 0.236 0.000
E07.9 Disorder of thyroid, unspecified
0.762 0.238 0.000
E31 Polyglandular dysfunction
0.760 0.240 0.000
D61 Other aplastic anaemias
0.759 0.241 0.000
M32.1 Systemic lupus erythematosus with organ or system involvement
0.756 0.244 0.000
D89 Other disorders involving the immune mechanism, not elsewhere classified
0.756 0.244 0.000
Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use
0.755 0.245 0.000
M24.8 Other specific joint derangements, not elsewhere classified
0.755 0.245 0.000
B25 Cytomegaloviral disease
0.753 0.247 0.000
E51 Thiamine deficiency
0.753 0.247 0.000
M25.7 Osteophyte
0.752 0.248 0.000
Q50 Congenital malformations of ovaries, Fallopian tubes and broad ligaments
0.751 0.249 0.000
M22 Disorders of patella
0.750 0.250 0.000
M24.28 Disorder of ligament (Other)
0.750 0.250 0.000
L84 Corns and callosities
0.749 0.251 0.000
I74.2 Embolism and thrombosis of arteries of the upper extremities
0.747 0.253 0.000
I74.5 Embolism and thrombosis of iliac artery
0.747 0.253 0.000
E10.8 With unspecified complications
0.746 0.254 0.000
E11.7 With multiple complications
0.744 0.256 0.000
E24 Cushing's syndrome
0.744 0.256 0.000
B37.7 Candidal septicaemia
0.743 0.257 0.000
M33 Dermatopolymyositis
0.742 0.258 0.000
E11.1 With ketoacidosis
0.741 0.259 0.000
E29.1 Testicular hypofunction
0.741 0.259 0.000
M25.76 Osteophyte (Lower leg)
0.741 0.259 0.000
L93 Lupus erythematosus
0.739 0.261 0.000
M00-M03 Infectious arthropathies
0.738 0.262 0.000
M24.4 Recurrent dislocation and subluxation of joint
0.735 0.265 0.000
E14.6 With other specified complications
0.733 0.266 0.000
Y42 Hormones and their synthetic substitutes and antagonists, not elsewhere classified
0.732 0.268 0.000
E27.3 Drug-induced adrenocortical insufficiency
0.730 0.269 0.000
B18.1 Chronic viral hepatitis B without delta-agent
0.730 0.270 0.000
D82 Immunodeficiency associated with other major defects
0.729 0.271 0.000
M60 Myositis
0.729 0.271 0.000
M21.8 Other specified acquired deformities of limbs
0.727 0.273 0.000
K74.5 Biliary cirrhosis, unspecified
0.726 0.274 0.000
M62 Other disorders of muscle
0.725 0.275 0.000
E02 Subclinical iodine-deficiency hypothyroidism
0.724 0.276 0.000
K72.0 Acute and subacute hepatic failure
0.724 0.276 0.000
L92.0 Granuloma annulare
0.724 0.276 0.000
L94.2 Calcinosis cutis
0.723 0.277 0.000
E07.8 Other specified disorders of thyroid
0.722 0.278 0.000
E23.6 Other disorders of pituitary gland
0.721 0.279 0.000
M35.2 Behcet's disease
0.720 0.280 0.000
M40-M43 Deforming dorsopathies
0.719 0.281 0.000
E58 Dietary calcium deficiency
0.718 0.282 0.000
E05.5 Thyroid crisis or storm
0.717 0.283 0.000
E05.4 Thyrotoxicosis factitia
0.717 0.283 0.000
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.717 0.283 0.000
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.717 0.283 0.000
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.717 0.283 0.000
E00 Congenital iodine-deficiency syndrome
0.717 0.283 0.000
E12 Malnutrition-related diabetes mellitus
0.717 0.283 0.000
E03.5 Myxoedema coma
0.717 0.283 0.000
E03.4 Atrophy of thyroid (acquired)
0.717 0.283 0.000
E03.3 Postinfectious hypothyroidism
0.717 0.283 0.000
E03.1 Congenital hypothyroidism without goitre
0.717 0.283 0.000
E03.0 Congenital hypothyroidism with diffuse goitre
0.717 0.283 0.000
Chapter XVI Certain conditions originating in the perinatal period
0.717 0.283 0.000
D81 Combined immunodeficiencies
0.716 0.283 0.000
E11.0 With coma
0.716 0.284 0.000
D86.2 Sarcoidosis of lung with sarcoidosis of lymph nodes
0.716 0.284 0.000
E20 Hypoparathyroidism
0.716 0.284 0.000
K90.3 Pancreatic steatorrhoea
0.715 0.284 0.000
K90.2 Blind loop syndrome, not elsewhere classified
0.715 0.284 0.000
K90.1 Tropical sprue
0.715 0.284 0.000
E15 Nondiabetic hypoglycaemic coma
0.715 0.285 0.000
M35.9 Systemic involvement of connective tissue, unspecified
0.715 0.285 0.000
M35.6 Relapsing panniculitis [Weber-Christian]
0.715 0.285 0.000
M35.5 Multifocal fibrosclerosis
0.715 0.285 0.000
M35.4 Diffuse (eosinophilic) fasciitis
0.715 0.285 0.000
B44 Aspergillosis
0.715 0.285 0.000
E16.1 Other hypoglycaemia
0.714 0.285 0.000
M36 Systemic disorders of connective tissue in diseases classified elsewhere
0.714 0.286 0.000
E35 Disorders of endocrine glands in diseases classified elsewhere
0.714 0.286 0.000
E32 Diseases of thymus
0.714 0.286 0.000
E30 Disorders of puberty, not elsewhere classified
0.714 0.286 0.000
E25 Adrenogenital disorders
0.714 0.286 0.000
E16.9 Disorder of pancreatic internal secretion, unspecified
0.714 0.286 0.000
E16.8 Other specified disorders of pancreatic internal secretion
0.714 0.286 0.000
E16.4 Abnormal secretion of gastrin
0.714 0.286 0.000
E16.3 Increased secretion of glucagon
0.714 0.286 0.000
Q44 Congenital malformations of gallbladder, bile ducts and liver
0.714 0.286 0.000
M24.15 Other articular cartilage disorders (Pelvic region and thigh)
0.713 0.287 0.000
I10-I15 Hypertensive diseases
0.713 0.287 0.000
A92-A99 Arthropod-borne viral fevers and viral haemorrhagic fevers
0.713 0.287 0.000
A75-A79 Rickettsioses
0.713 0.287 0.000
A70-A74 Other diseases caused by chlamydiae
0.713 0.287 0.000
A20-A28 Certain zoonotic bacterial diseases
0.713 0.287 0.000
B37.2 Candidiasis of skin and nail
0.713 0.287 0.000
M34.1 CR(E)ST syndrome
0.712 0.288 0.000
A80-A89 Viral infections of the central nervous system
0.712 0.288 0.000
E53.8 Deficiency of other specified B group vitamins
0.712 0.288 0.000
I74.8 Embolism and thrombosis of other arteries
0.711 0.289 0.000
B48 Other mycoses, not elsewhere classified
0.711 0.289 0.000
B47 Mycetoma
0.711 0.289 0.000
B46 Zygomycosis
0.711 0.289 0.000
B45 Cryptococcosis
0.711 0.289 0.000
B43 Chromomycosis and phaeomycotic abscess
0.711 0.289 0.000
B42 Sporotrichosis
0.711 0.289 0.000
B41 Paracoccidioidomycosis
0.711 0.289 0.000
B40 Blastomycosis
0.711 0.289 0.000
B39 Histoplasmosis
0.711 0.289 0.000
B38 Coccidioidomycosis
0.711 0.289 0.000
E27.5 Adrenomedullary hyperfunction
0.711 0.289 0.000
E27.0 Other adrenocortical overactivity
0.711 0.289 0.000
B37.6 Candidal endocarditis
0.710 0.289 0.000
B37.5 Candidal meningitis
0.710 0.289 0.000
Y42.7 Androgens and anabolic congeners
0.710 0.290 0.000
L20-L30 Dermatitis and eczema
0.708 0.292 0.000
A65-A69 Other spirochaetal diseases
0.708 0.292 0.000
E14.7 With multiple complications
0.707 0.292 0.000
E14.0 With coma
0.707 0.292 0.000
A50-A64 Infections with a predominantly sexual mode of transmission
0.706 0.294 0.000
B36 Other superficial mycoses
0.705 0.295 0.000
H30 Chorioretinal inflammation
0.705 0.295 0.000
B85-B89 Pediculosis, acariasis and other infestations
0.704 0.296 0.000
Y54 Agents primarily affecting water-balance and mineral and uric acid metabolism
0.704 0.296 0.000
E61.1 Iron deficiency
0.701 0.299 0.000
D69 Purpura and other haemorrhagic conditions
0.701 0.299 0.000
I95-I99 Other and unspecified disorders of the circulatory system
0.701 0.299 0.000
D61.9 Aplastic anaemia, unspecified
0.700 0.300 0.000
E10.0 With coma
0.699 0.301 0.000
D80.2 Selective deficiency of immunoglobulin A [IgA]
0.698 0.302 0.000
B15 Acute hepatitis A
0.697 0.303 0.000
E14.5 With peripheral circulatory complications
0.696 0.303 0.000
M21.0 Valgus deformity, not elsewhere classified
0.696 0.304 0.000
A30-A49 Other bacterial diseases
0.696 0.304 0.000
H03.8 Involvement of eyelid in other diseases classified elsewhere
0.695 0.305 0.000
B16 Acute hepatitis B
0.695 0.305 0.000
M24.21 Disorder of ligament (Shoulder region)
0.695 0.305 0.000
Q90-Q99 Chromosomal abnormalities, not elsewhere classified
0.695 0.305 0.000
K77 Liver disorders in diseases classified elsewhere
0.695 0.305 0.000
K71 Toxic liver disease
0.695 0.305 0.000
K75.3 Granulomatous hepatitis, not elsewhere classified
0.695 0.305 0.000
K93 Disorders of other digestive organs in diseases classified elsewhere
0.695 0.305 0.000
L80 Vitiligo
0.694 0.306 0.000
M24.9 Joint derangement, unspecified
0.693 0.307 0.000
Q00-Q07 Congenital malformations of the nervous system
0.693 0.307 0.000
E61.2 Magnesium deficiency
0.692 0.308 0.000
M24.75 Protrusio acetabuli-Pelvic/thigh
0.692 0.308 0.000
B90-B94 Sequelae of infectious and parasitic diseases
0.692 0.308 0.000
B19 Unspecified viral hepatitis
0.691 0.309 0.000
M35.7 Hypermobility syndrome
0.691 0.309 0.000
Y60-Y69 Misadventures to patients during surgical and medical care
0.691 0.309 0.000
M21.6 Other acquired deformities of ankle and foot
0.690 0.310 0.000
B18.9 Chronic viral hepatitis, unspecified
0.689 0.310 0.000
E10.6 With other specified complications
0.688 0.312 0.000
L28 Lichen simplex chronicus and prurigo
0.687 0.313 0.000
E06.5 Other chronic thyroiditis
0.685 0.315 0.000
Y52 Agents primarily affecting the cardiovascular system
0.684 0.316 0.000
E23.7 Disorder of pituitary gland, unspecified
0.684 0.316 0.000
K75.2 Nonspecific reactive hepatitis
0.683 0.317 0.000
K75.1 Phlebitis of portal vein
0.683 0.317 0.000
E40-E46 Malnutrition
0.683 0.317 0.000
H15-H22 Disorders of sclera, cornea, iris and ciliary body
0.682 0.318 0.000
H05.4 Enophthalmos
0.681 0.319 0.000
V01-V09 Pedestrian injured in transport accident
0.680 0.320 0.000
M35.3 Polymyalgia rheumatica
0.679 0.321 0.000
H46-H48 Disorders of optic nerve and visual pathways
0.677 0.323 0.000
H04.8 Other disorders of lachrymal system
0.676 0.324 0.000
Q51.8 Other congenital malformations of uterus and cervix
0.676 0.324 0.000
L94.9 Localised connective tissue disorder, unspecified
0.676 0.324 0.000
H06.3 Other disorders of orbit in diseases classified elsewhere
0.675 0.325 0.000
H06.1 Parasitic infestation of orbit in diseases classified elsewhere
0.675 0.325 0.000
H06.0 Disorders of lachrymal system in diseases classified elsewhere
0.675 0.325 0.000
H43 Disorders of vitreous body
0.675 0.325 0.000
Q65-Q79 Congenital malformations and deformations of the musculoskeletal system
0.674 0.326 0.000
M89 Other disorders of bone
0.673 0.327 0.000
Y53 Agents primarily affecting the gastro-intestinal system
0.672 0.328 0.000
L52 Erythema nodosum
0.672 0.328 0.000
Q53 Undescended testicle
0.672 0.328 0.000
I12 Hypertensive renal disease
0.670 0.330 0.000
E23.0 Hypopituitarism
0.669 0.331 0.000
M35.1 Other overlap syndromes
0.669 0.331 0.000
H05.5 Retained (old) foreign body following penetrating wound of orbit
0.668 0.332 0.000
H05.3 Deformity of orbit
0.668 0.332 0.000
H05.1 Chronic inflammatory disorders of orbit
0.668 0.332 0.000
H04.4 Chronic inflammation of lachrymal passages
0.667 0.332 0.000
K90.8 Other intestinal malabsorption
0.667 0.333 0.000
M95-M99 Other disorders of the musculoskeletal system and connective tissue
0.667 0.333 0.000
E64 Sequelae of malnutrition and other nutritional deficiencies
0.667 0.333 0.000
E63 Other nutritional deficiencies
0.667 0.333 0.000
E56 Other vitamin deficiencies
0.667 0.333 0.000
E50 Vitamin A deficiency
0.667 0.333 0.000
E60 Dietary zinc deficiency
0.667 0.333 0.000
E59 Dietary selenium deficiency
0.667 0.333 0.000
E54 Ascorbic acid deficiency
0.667 0.333 0.000
E52 Niacin deficiency [pellagra]
0.667 0.333 0.000
D80.9 Immunodeficiency with predominantly antibody defects, unspecified
0.666 0.334 0.000
B23 Human immunodeficiency virus [HIV] disease resulting in other conditions
0.666 0.334 0.000
X20-X29 Contact with venomous animals and plants
0.665 0.335 0.000
K74.4 Secondary biliary cirrhosis
0.664 0.336 0.000
K74.2 Hepatic fibrosis with hepatic sclerosis
0.664 0.336 0.000
K74.1 Hepatic sclerosis
0.664 0.336 0.000
D59 Acquired haemolytic anaemia
0.663 0.337 0.000
E06.4 Drug-induced thyroiditis
0.662 0.338 0.000
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.662 0.338 0.000
E06.1 Subacute thyroiditis
0.662 0.338 0.000
E06.0 Acute thyroiditis
0.662 0.338 0.000
B18.8 Other chronic viral hepatitis
0.660 0.339 0.000
B18.0 Chronic viral hepatitis B with delta-agent
0.660 0.339 0.000
L12 Pemphigoid
0.660 0.339 0.000
Q50.4 Embryonic cyst of Fallopian tube
0.660 0.340 0.000
L28.0 Lichen simplex chronicus
0.660 0.340 0.000
L95 Vasculitis limited to skin, not elsewhere classified
0.659 0.340 0.000
I77 Other disorders of arteries and arterioles
0.659 0.341 0.000
M24.51 Contracture of joint (Shoulder region)
0.659 0.341 0.000
I98 Other disorders of circulatory system in diseases classified elsewhere
0.659 0.341 0.000
E22 Hyperfunction of pituitary gland
0.659 0.341 0.000
M24.29 Disorder of ligament (Site unspecified)
0.658 0.341 0.000
M24.25 Disorder of ligament (Pelvic region and thigh)
0.658 0.341 0.000
M24.22 Disorder of ligament (Upper arm)
0.658 0.341 0.000
M24.20 Disorder of ligament (Multiple sites)
0.658 0.341 0.000
M86.6 Other chronic osteomyelitis
0.658 0.342 0.000
I70 Atherosclerosis
0.657 0.343 0.000
M30 Polyarteritis nodosa and related conditions
0.657 0.343 0.000
D84 Other immunodeficiencies
0.656 0.344 0.000
V20-V29 Motorcycle rider injured in transport accident
0.655 0.345 0.000
M24.85 Other specific joint derangements, not elsewhere classified (Pelvic region and thigh)
0.654 0.346 0.000
B49 Unspecified mycosis
0.654 0.346 0.000
Q35-Q37 Cleft lip and cleft palate
0.653 0.347 0.000
Q30-Q34 Congenital malformations of the respiratory system
0.653 0.347 0.000
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.653 0.347 0.000
H04.3 Acute and unspecified inflammation of lachrymal passages
0.653 0.347 0.000
Y41 Other systemic anti-infectives and antiparasitics
0.651 0.349 0.000
K72.1 Chronic hepatic failure
0.651 0.349 0.000
Q43.3 Congenital malformations of intestinal fixation
0.651 0.349 0.000
B25.9 Cytomegaloviral disease, unspecified
0.650 0.350 0.000
M25.68 Stiffness of joint, not elsewhere classified (Other)
0.648 0.352 0.000
E27.9 Disorder of adrenal gland, unspecified
0.648 0.352 0.000
E13.9 Without complications
0.648 0.352 0.000
M34.9 Systemic sclerosis, unspecified
0.646 0.353 0.000
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.646 0.354 0.000
E23.1 Drug-induced hypopituitarism
0.646 0.354 0.000
I12.9 Hypertensive renal disease without renal failure
0.646 0.354 0.000
I73.8 Other specified peripheral vascular diseases
0.645 0.355 0.000
X58-X59 Accidental exposure to other and unspecified factors
0.644 0.356 0.000
M24.11 Other articular cartilage disorders (Shoulder region)
0.644 0.356 0.000
Q43.8 Other specified congenital malformations of intestine
0.644 0.356 0.000
K73.8 Other chronic hepatitis, not elsewhere classified
0.642 0.358 0.000
K73.1 Chronic lobular hepatitis, not elsewhere classified
0.642 0.358 0.000
K73.0 Chronic persistent hepatitis, not elsewhere classified
0.642 0.358 0.000
Q51.3 Bicornate uterus
0.639 0.361 0.000
I74.4 Embolism and thrombosis of arteries of extremities, unspecified
0.639 0.361 0.000
I79.8 Other disorders of arteries, arterioles and capillaries in diseases classified elsewhere
0.638 0.362 0.000
Q51.2 Other doubling of uterus
0.638 0.362 0.000
Q40 Other congenital malformations of upper alimentary tract
0.637 0.362 0.000
M24.41 Recurrent dislocation and subluxation of joint (Shoulder region)
0.637 0.363 0.000
D89.9 Disorder involving the immune mechanism, unspecified
0.636 0.364 0.000
E07.1 Dyshormogenetic goitre
0.635 0.364 0.000
E07.0 Hypersecretion of calcitonin
0.635 0.364 0.000
M24.6 Ankylosis of joint
0.635 0.365 0.000
Y47 Sedatives, hypnotics and antianxiety drugs
0.635 0.365 0.000
M21.5 Acquired clawhand, clubhand, clawfoot and clubfoot
0.634 0.366 0.000
Y52.3 Coronary vasodilators, not elsewhere classified
0.634 0.366 0.000
D64 Other anaemias
0.633 0.367 0.000
I00-I02 Acute rheumatic fever
0.633 0.367 0.000
M34.0 Progressive systemic sclerosis
0.632 0.368 0.000
E11.9 Without complications
0.632 0.368 0.000
I26-I28 Pulmonary heart disease and diseases of pulmonary circulation
0.631 0.369 0.000
M21.7 Unequal limb length (acquired)
0.630 0.370 0.000
E27.2 Addisonian crisis
0.629 0.371 0.000
M86.9 Osteomyelitis, unspecified
0.628 0.372 0.000
B17.1 Acute hepatitis C
0.628 0.372 0.000
D50-D53 Nutritional anaemias
0.628 0.372 0.000
H43.1 Vitreous haemorrhage
0.628 0.372 0.000
M60.9 Myositis, unspecified
0.628 0.372 0.000
L99 Other disorders of skin and subcutaneous tissue in diseases classified elsewhere
0.627 0.373 0.000
L87 Transepidermal elimination disorders
0.627 0.373 0.000
L86 Keratoderma in diseases classified elsewhere
0.627 0.373 0.000
B33 Other viral diseases, not elsewhere classified
0.626 0.373 0.000
E51.2 Wernicke's encephalopathy
0.626 0.374 0.000
M24.23 Disorder of ligament (Forearm)
0.625 0.374 0.000
L10 Pemphigus
0.625 0.374 0.000
L14 Bullous disorders in diseases classified elsewhere
0.625 0.374 0.000
B22 Human immunodeficiency virus [HIV] disease resulting in other specified diseases
0.625 0.375 0.000
B21 Human immunodeficiency virus [HIV] disease resulting in malignant neoplasms
0.625 0.375 0.000
B20 Human immunodeficiency virus [HIV] disease resulting in infectious and parasitic diseases
0.625 0.375 0.000
E14.4 With neurological complications
0.624 0.376 0.000
D80.3 Selective deficiency of immunoglobulin G [IgG] subclasses
0.624 0.376 0.000
M63 Disorders of muscle in diseases classified elsewhere
0.624 0.376 0.000
M61 Calcification and ossification of muscle
0.624 0.376 0.000
L53 Other erythematous conditions
0.624 0.376 0.000
B50-B64 Protozoal diseases
0.622 0.378 0.000
M21.86 Other specified acquired deformities of limbs (Lower leg)
0.620 0.380 0.000
H32 Chorioretinal disorders in diseases classified elsewhere
0.620 0.380 0.000
D83.8 Other common variable immunodeficiencies
0.620 0.380 0.000
D83.2 Common variable immunodeficiency with autoantibodies to B- or T-cells
0.620 0.380 0.000
D83.1 Common variable immunodeficiency with predominant immunoregulatory T-cell disorders
0.620 0.380 0.000
D83.0 Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function
0.620 0.380 0.000
D86.3 Sarcoidosis of skin
0.619 0.381 0.000
M21.9 Acquired deformity of limb, unspecified
0.619 0.381 0.000
D61.1 Drug-induced aplastic anaemia
0.618 0.382 0.000
I98.2 Oesophageal varices in diseases classified elsewhere
0.618 0.382 0.000
L94.8 Other specified localised connective tissue disorders
0.618 0.382 0.000
L98 Other disorders of skin and subcutaneous tissue, not elsewhere classified
0.618 0.382 0.000
H05.9 Disorder of orbit, unspecified
0.617 0.383 0.000
Q45 Other congenital malformations of digestive system
0.617 0.383 0.000
M35.8 Other specified systemic involvement of connective tissue
0.617 0.383 0.000
H36.8 Other retinal disorders in diseases classified elsewhere
0.616 0.384 0.000
M88 Paget's disease of bone [osteitis deformans]
0.616 0.384 0.000
H04.6 Other changes in lachrymal passages
0.616 0.384 0.000
B65-B83 Helminthiases
0.615 0.384 0.000
M24.54 Contracture of joint (Hand)
0.616 0.384 0.000
I73.1 Thromboangiitis obliterans [Buerger]
0.615 0.385 0.000
Q60-Q64 Congenital malformations of the urinary system
0.615 0.385 0.000
Y51 Drugs primarily affecting the autonomic nervous system
0.614 0.386 0.000
H49-H52 Disorders of ocular muscles, binocular movement, accommodation and refraction
0.614 0.386 0.000
M32.9 Systemic lupus erythematosus, unspecified
0.614 0.386 0.000
M32.8 Other forms of systemic lupus erythematosus
0.614 0.386 0.000
M32.0 Drug-induced systemic lupus erythematosus
0.614 0.386 0.000
E24.2 Drug-induced Cushing's syndrome
0.613 0.387 0.000
M40 Kyphosis and lordosis
0.613 0.387 0.000
M22.0 Recurrent dislocation of patella
0.612 0.388 0.000
B35 Dermatophytosis
0.611 0.389 0.000
Q56 Indeterminate sex and pseudohermaphroditism
0.610 0.390 0.000
L94.0 Localised scleroderma [morphea]
0.610 0.390 0.000
D80.1 Nonfamilial hypogammaglobulinaemia
0.609 0.390 0.000
D58 Other hereditary haemolytic anaemias
0.609 0.391 0.000
D80.8 Other immunodeficiencies with predominantly antibody defects
0.609 0.391 0.000
D80.7 Transient hypogammaglobulinaemia of infancy
0.609 0.391 0.000
D80.6 Antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinaemia
0.609 0.391 0.000
D80.5 Immunodeficiency with increased immunoglobulin M [IgM]
0.609 0.391 0.000
D80.4 Selective deficiency of immunoglobulin M [IgM]
0.609 0.391 0.000
D80.0 Hereditary hypogammaglobulinaemia
0.609 0.391 0.000
B25.0 Cytomegaloviral pneumonitis
0.608 0.392 0.000
M86.1 Other acute osteomyelitis
0.608 0.392 0.000
E29.9 Testicular dysfunction, unspecified
0.607 0.393 0.000
E29.8 Other testicular dysfunction
0.607 0.393 0.000
E29.0 Testicular hyperfunction
0.607 0.393 0.000
L93.0 Discoid lupus erythematosus
0.607 0.393 0.000
Y54.3 Benzothiadiazine derivatives
0.606 0.394 0.000
I79.1 Aortitis in diseases classified elsewhere
0.605 0.395 0.000
I79.0 Aneurysm of aorta in diseases classified elsewhere
0.605 0.395 0.000
L13.9 Bullous disorder, unspecified
0.605 0.395 0.000
L13.8 Other specified bullous disorders
0.605 0.395 0.000
L13.1 Subcorneal pustular dermatitis
0.605 0.395 0.000
M24.86 Other specific joint derangements, not elsewhere classified (Lower leg)
0.605 0.395 0.000
M62.8 Other specified disorders of muscle
0.605 0.395 0.000
Q43.9 Congenital malformation of intestine, unspecified
0.605 0.395 0.000
H03.1 Involvement of eyelid in other infectious diseases classified elsewhere
0.604 0.396 0.000
A41 Other septicaemia
0.604 0.396 0.000
Y42.2 Antithyroid drugs
0.604 0.396 0.000
I74.1 Embolism and thrombosis of other and unspecified parts of aorta
0.603 0.397 0.000
M22.3 Other derangements of patella
0.603 0.397 0.000
M25.4 Effusion of joint
0.601 0.399 0.000
Q44.5 Other congenital malformations of bile ducts
0.600 0.400 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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